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Abraxis Bioscience Llc patents


Recent patent applications related to Abraxis Bioscience Llc. Abraxis Bioscience Llc is listed as an Agent/Assignee. Note: Abraxis Bioscience Llc may have other listings under different names/spellings. We're not affiliated with Abraxis Bioscience Llc, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "A" | Abraxis Bioscience Llc-related inventors


Methods and compositions for treating pulmonary hypertension

The present invention features methods for treating, stabilizing, preventing, and/or delaying pulmonary hypertension by administering nanoparticles that comprise rapamycin or a derivative thereof and/or nanoparticles that comprise a taxane (e.g., paclitaxel) or a derivative thereof. The invention also provides compositions (e.g., unit dosage forms) comprising nanoparticles that comprise a carrier protein and rapamycin or a derivative thereof and/or nanoparticles that comprise a carrier protein and a taxane (e.g., paclitaxel) or a derivative4 thereof.. ... Abraxis Bioscience Llc

Method for treating cancer based on level of glucocorticoid receptor

The present invention provides methods and compositions for treating cancer with taxane-based therapy. The individuals may have a high level of glucocorticoid receptor (gr) and/or a high level of glucocorticoid (gc). ... Abraxis Bioscience Llc

Combinations and modes of administration of therapeutic agents and combination therapy

The present invention provides combination therapy methods of treating proliferative diseases (such as cancer) comprising a first therapy comprising administering to an individual an effective amount of a taxane in a nanoparticle composition, and a second therapy which may include, for example, radiation, surgery, administration of chemotherapeutic agents (such as an anti-vegf antibody), or combinations thereof. Also provided are methods of administering to an individual a drug taxane in a nanoparticle composition based on a metronomic dosing regime.. ... Abraxis Bioscience Llc

Breast cancer therapy based on hormone receptor status with nanoparticles comprising taxane

The present invention relates to methods and kits for the treatment of breast cancer based on hormone receptor status of progesterone receptor and estrogen receptor comprising the administration of a taxane alone, in combination with at least one other and other therapeutic agents, as well as other treatment modalities useful in the treatment of breast cancer. In particular, the invention relates to the use of nanoparticles comprising paclitaxel and albumin (such as abraxane®) either alone or in combination with other chemotherapeutic agents or radiation, which may be used for the treatment of breast cancer which does not express estrogen receptor and/or progesterone receptor.. ... Abraxis Bioscience Llc

Methods of treating melanoma

Provided herein are methods for the treatment of melanoma comprising administration of a composition comprising nanoparticles comprising taxane and a carrier protein.. . ... Abraxis Bioscience Llc

Use of polymeric excipients for lyophilization or freezing of particles

Provided herein are use of polymeric excipients, specifically polyvinyl alcohols, optionally in conjunction with sugars, as cryoprotectants to prevent aggregation of peg-containing particles. Also provided are peg-containing particles comprising such polymeric excipients.. ... Abraxis Bioscience Llc

Drugs with improved hydrophobicity for incorporation in medical devices

The invention provides a medical device comprising a hydrophobic analog of a medicament known to inhibit cell proliferation and migration. The invention also provides a method of treating a narrowing in a body passageway comprising placing an implantable medical device comprising a hydrophobic analog of a medicament known to inhibit cell proliferation and migration. ... Abraxis Bioscience Llc

Combination therapy comprising nanoparticles of a taxane and albumin with abt-263 in methods for treating cancer

Provided are methods of treating a cancer (such as lung cancer, breast cancer, pancreatic cancer, etc.) in an individual in need thereof, comprising administering to the individual a) an effective amount of a composition comprising nanoparticles comprising a taxane (such as paclitaxel) and an albumin (such as human serum albumin), and b) an effective amount of abt-263.. . ... Abraxis Bioscience Llc

Combination therapy methods for treating proliferative diseases

The present invention provides combination therapy methods of treating a proliferative disease (such as cancer) comprising a first therapy comprising administering to an individual an effective amount of a taxane in a nanoparticle composition, and a second therapy which may include the administration of an effective amount of at least one other agent that modifies the epigenetics in a cell.. . ... Abraxis Bioscience Llc

Nanoparticle formulations and uses thereof

The present invention provides compositions comprising nanoparticles comprising: 1) a drug, such as a hydrophobic drug derivative; and 2) a carrier protein. Also provided are methods of treating diseases (such as cancer) using the compositions, as well as kits and unit dosages.. ... Abraxis Bioscience Llc

Intravascular delivery of nanoparticle compositions and uses thereof

The present invention provides methods of delivering a composition comprising nanoparticles that comprise a macrolide and an albumin by directly injecting the nanoparticle composition into the blood vessel wall or the tissue surrounding the blood vessel wall. The methods can be used for inhibiting negative remodeling or vascular fibrosis in the blood vessel and are useful for treating various diseases.. ... Abraxis Bioscience Llc

Combination therapy with thiocolchicine derivatives

The present invention provides combination therapy methods of treating a proliferative disease (such as cancer) comprising administering to an individual an effective amount of a colchicine or thiocolchicine dimer and an anti-vegf antibody. The method may further comprise administering an effective amount of a taxane. ... Abraxis Bioscience Llc

Prion free nanoparticle compositions and methods of making thereof

The present invention provides prion-free compositions comprising nanoparticles comprising albumin and substantially water insoluble drugs. Also provided are methods of making prion-free compositions and methods of removing prion proteins from the nanoparticle compositions. ... Abraxis Bioscience Llc

Methods of treatment of pancreatic cancer

The present invention provides methods and compositions for treating pancreatic cancer in an individual who has been previously treated for pancreatic cancer (e.g., gemcitabine-based therapy) by administering a composition comprising nanoparticles that comprise a taxane and an albumin. The invention also provides combination therapy methods of treating pancreatic cancer (for example, in an individual who has been previously treated for pancreatic cancer) comprising administering to an individual an effective amount of a composition comprising nanoparticles that comprise a taxane and an albumin and another agent.. ... Abraxis Bioscience Llc

01/26/17 / #20170020824

Methods of treating pancreatic cancer

Provided herein are methods for the treatment of metastatic pancreatic cancer comprising administration of a composition comprising nanoparticles comprising a taxane (such as paclitaxel) and a carrier protein in combination with gemcitabine.. . ... Abraxis Bioscience Llc

01/19/17 / #20170014373

Methods of treating cancer

The present invention provides methods and compositions for treating non-small-cell lung cancer (nsclc) by administering a) a composition comprising nanoparticles that comprise paclitaxel and an albumin and b) a platinum-based agent (e.g., carboplatin). The present application also provides methods of treating prostate cancer by administering to the individual a) an effective amount of a composition comprising nanoparticles comprising docetaxel and an albumin; and b) an effective amount of a steroid.. ... Abraxis Bioscience Llc

01/12/17 / #20170007569

Compositions and methods for preparation of poorly water soluble drugs with increased stability

The present invention provides stable pharmaceutical compositions of poorly water soluble pharmaceutical agents and stabilizing agents which function to increase stability of the compositions. The use of stabilizing agents provide extended stability of nanoparticle suspensions and other formulations of poorly water soluble pharmaceutical agents such as docetaxel under certain conditions, for example upon dilution for administration.. ... Abraxis Bioscience Llc








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