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Academia Sinica
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Academia Sinica patents


Recent patent applications related to Academia Sinica. Academia Sinica is listed as an Agent/Assignee. Note: Academia Sinica may have other listings under different names/spellings. We're not affiliated with Academia Sinica, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "A" | Academia Sinica-related inventors


A therapeutic gene cocktail for heart regeneration

A combination of active agents selected from a FoxM1 enhancer, an Id1 enhancer, and a JNK3 inhibitor and the uses thereof in promoting cardiomyocyte proliferation and treating heart diseases in a subject in need of the treatment.... Academia Sinica

Platelet-like proteo-microparticles and using such in drug delivery

Proteo-microparticles such as proteoliposomes comprising a microparticle (e.g., a liposome) and platelet membrane proteins, wherein the proteo-microparticles are capable of binding to monocytes, neutrophils, or other circulating blood cells capable of migrating to an injured site. Also provided herein are uses of the proteoliposomes for delivering a therapeutic agent via... Academia Sinica

Methods for enhancing maturation of cardiomyocytes

Methods for promoting maturation of cardiomyocytes, involving introducing a microRNA combination containing miR-125b, miR-199a, miR-221, and/or miR222, or suppression of ErbB4 in immature cardiomyocytes, which may be co-cultured with endothelial cells.... Academia Sinica

Divide-and-conquer global alignment algorithm for finding highly similar candidates of a sequence in database

A divide-and-conquer global alignment algorithm for finding highly similar candidates of a sequence in database is disclosed. The invention gives a divide-and-conquer algorithm called Kart, that separates the given sequence into smaller pieces whose alignment can be carried out independently, and their concatenated alignment constitutes the global alignment of the... Academia Sinica

Method for preparing induced mesenchymal stem cells and improving mesenchymal stem cell's characters and its applications

The present invention generally relates to a method for preparing induced mesenchymal stem cells (iMSCs) and its applications. The iMSCs, like MSCs, can differentiate into multiple lineages, which may be beneficial for disease treatments. In addition, the present invention also provides a method for improving the MSC's functional characteristics such... Academia Sinica

Endoglycosidase mutants for glycoprotein remodeling and methods of using it

A mutant of EndoS2 includes one or more mutations in the sequence of a wild-type EndoS2 (SEQ ID NO: 1), wherein the one or more mutations are in a peptide region located within residues 133-143, residues 177-182, residues 184-189, residues 221-231, and/or residues 227-237, wherein the mutant of EndoS2 has... Academia Sinica

Development of a standardized and effect-optimized herbal extract of wedelia chinensis and its use for treating disease

A method for preparing a standardized Wedelia chinensis extract and an extract prepared by the method. Also provided is a method for qualifying the standardized extract by characterizing its most abundant compounds and its biological activity in vitro. Additionally, a method is provided for treating an androgen-stimulated disorder with the... Academia Sinica

Anti-inflammatory molecules with tissue-targeting functions

The present disclosure provides various molecular constructs having a targeting element and an effector element. Methods for treating osteoporosis using such molecular constructs are also disclosed.... Academia Sinica

Epitope-substituted vaccine for use in improving safety and immunogenicity against dengue viruses

Isolated mutant dengue virus E protein variants are disclosed. The variant comprises an amino acid sequence that is at least 80% identical to SEQ ID NO: 1 and has one or more amino acid residue substitutions at position corresponding to Asn8 (N8), Arg9 (R9), Val12 (V12) and/or Glu13 (E13). The... Academia Sinica

Mutated nucleotide molecule, and transformed plant cells and plants comprising the same

The present invention relates to a method for producing male sterile plant, a mutated nucleotide molecule comprising a nucleotide sequence of the transcription factor bHLH142 and an inserted T-DNA segment, and a novel transformed plant cell and a male-sterile mutant plant comprising the mutated nucleotide molecule, in which the transcription... Academia Sinica

Probes and methods for detecting amyloidogenic proteins

Disclosed herein are novel photocontrollable probes and methods for detecting aggregated forms of amyloidogenic proteins in cells, tissues, or organs of a live subject. Results of such detection may be useful for making prognosis on the subject whether he/she suffers from a neurodegenerative disease and/or diabetes mellitus.... Academia Sinica

Computational predicting functional sites of biological molecules

In a general aspect, a method for inferring one or more biomolecule-to-biomolecule interaction sites includes receiving data representative of a plurality of prediction models. Each prediction model is associated with a different atom type of a plurality of atom types and characterizes biomolecule-to-biomolecule interaction site specific patterns common to a... Academia Sinica

A phage-displayed single-chain variable fragment library

Disclosed herein is a phage-displayed single-chain variable fragment (scFv) library, that comprised a plurality of phage-displayed scFvs characterized with (1) a specific CS combination; (2) a specific distribution of aromatic residues in each CDR; and (3) a specific sequence in each CDR. The present scFv library could be used to... Academia Sinica

Reactive labelling compounds and uses thereof

Provided are azido-BODIPY compounds of formula (I), cyclooctyne-based fluorogenic probes of formula (IV), and activity-based probes of formula (VI). These compounds undergo azide-alkyne cycloadditions (AAC) with to form triazolyl products. The provided compounds are useful for detection and imaging of alkyne-, or azide-containing molecules. Methods for detection and imaging biomolecules... Academia Sinica

Use of polyacetylenic glycosides for suppression of granulocytic myeloid-derived suppressor cell activities and tumor metastasis

A pharmacological composition for use in inhibiting differentiation, functional activities, and population of granulo-cytic myeloid-derived suppressor cells (gMDSCs) and/or suppressing, tumor metastasis in a subject in need thereof is disclosed. The composition comprises a therapeutically effective amount of Bidens pilosa extract, or more than one polyacetylenic compounds purified or isolated... Academia Sinica

Method for treating influenza a virus infection

Disclosed herein is a method of treating influenza A virus (IAV) infection by a fusion protein. According to some embodiments of the present disclosure, the fusion protein comprises a HBD peptide and a IgG1 Fc region. According to other embodiments of the present disclosure, the fusion protein comprises a DcR3... Academia Sinica

Human inkt cell activation using glycolipids with altered glycosyl groups

Glycosphingolipids (GSLs) bearing α-glucose (α-Glc) that preferentially stimulate human invariant NKT (iNKT) cells are provided. GSLs with α-glucose (α-Glc) that exhibit stronger induction in humans (but weaker in mice) of cytokines and chemokines and expansion and/or activation of immune cells than those with α-galactose (α-Gal) are disclosed. GSLs bearing α-glucose... Academia Sinica

Methods for modular synthesis of n-glycans and arrays thereof

The present disclosure relates to novel modular methods for generating a diversity of N-glycans of high mannose, hybrid and complex types. The present disclosure also relates to exemplary arrays of the synthesized N-glycans spotted onto aluminium oxide coated slides. These arrays can be used to detect and analyze binding interactions... Academia Sinica

High-throughput screening of functional antibody fragments, immunoconjugate comprising the same, and adaptor-drug conjugate for screening

Disclosed herein are methods for high-throughput screening of a functional antibody fragment for an immunoconjugate that targets a protein antigen. The method combines a phage-displayed synthetic antibody library and high-throughput cytotoxicity screening of non-covalently assembled immunotoxins or cytotoxic drug to identify highly functional synthetic antibody fragments for delivering toxin payloads.... Academia Sinica

Use of an antimicrobial peptide tp4 in treating a cancer

The preset invention relates to a new approach for treating a cancer, particularly a malignant tumor, a multidrug-resistant (MDR) cancer, a recurrent cancer or a metastatic cancer, using a specific cationic antimicrobial peptide (CAP), tilapia piscidin 4 (TP4), which is derived from Nile Tilapia (Oreochromis niloticus). Also provided is a... Academia Sinica

Plant defense signaling peptides and applications thereof

The present invention relates to a novel plant defense signaling peptide and applications thereof.... Academia Sinica

Antibodies against pathological forms of tdp-43 and uses thereof

Disclosed herein are novel pathological form of TDP-43, monoclonal antibodies against such pathological form of TDP-43, and uses thereof. The novel pathological form of TDP-43 is characterized in having a spherical particle size of about 2 to 400 nm in diameter.... Academia Sinica

Compounds and methods for analysis and synthesis of saccharide compounds, and quantitating saccharide

Provided is a method for quantitating a saccharide in a liquid sample. The method comprises incubating the liquid sample with 2,3-naphthalenediamine in the presence of iodine to allow a naphthimidazole group to be linked to the saccharide to obtain a first mixture; obtaining an 1H-NMR spectrum of the first mixture;... Academia Sinica

Curved diffraction grating, spectrometer and manufacturing curved diffraction grating

A curved diffraction grating includes a substrate and a metal layer. The substrate is a two-dimensional curved plate structure and has a first surface, a second surface and a plurality of microstructures. The first surface is disposed opposite to the second surface, and the microstructures are disposed on the second... Academia Sinica

Methods and compositions for treating beta-thalassemia and sickle cell disease

Compounds, pharmaceutical compositions, and methods for treating anemia β-thalassemia anemia or sickle cell anemia.... Academia Sinica

Treatment of neurodevelopmental disorders

Disclosed herein are methods for treating a neurodevelopmental disorder in a subject in need thereof. The method includes administering to the subject in need thereof an effective amount of a methyl-CpG-binding protein 2 (MeCP2) or a nucleic acid encoding the MeCP2 to alleviate or ameliorate the symptoms associated with the... Academia Sinica

Animal model of longevity and related methods for increasing longevity and inhibiting tumorigenesis

The present invention includes a genetically-modified non-human animal model of longevity and increased health span, which is associated with reduced tumorigenesis and tumor metastasis, as well as related methods for increasing longevity and health span, reducing tumorigenesis and tumor metastasis, and identifying active agents that confer increased longevity or health... Academia Sinica

Methods for enhancing permeability to blood-brain barrier, and uses thereof

Disclosed herein is a method of facilitating the delivery of an agent across blood-brain barrier (BBB) of a subject. The method includes administering to the subject in sequence or concomitantly, an effective amount of a growth factor selected from the group consisting of, vascular endothelial growth factor (VEGF), insulin-like growth... Academia Sinica

Dna sequence and a mutator insertion sequence for increasing mutation rate

The invention relates to a DNA sequence for increase of a mutation rate over a specific region of DNA. Particularly, the invention provides a unique guanine nucleotide sequence and a mutator insertion sequence incorporated with the guanine nucleotide sequence and their applications in increasing a mutation rate.... Academia Sinica

Modulation of globoseries glycosphingolipid synthesis and cancer biomarkers

The present disclosure relates to methods and compositions which can modulate the globoseries glycosphingolipid synthesis. Particularly, the present disclosure is directed to glycoenzyme inhibitor compound and compositions and methods of use thereof that can modulate the synthesis of globoseries glycosphingolipid SSEA-3/SSEA-4/GloboH in the biosynthetic pathway; particularly, the glycoenzyme inhibitors target... Academia Sinica

Novel glycan conjugates and use thereof

This disclosure includes an immunogenic composition containing (a) a glycan conjugate including a carrier and one or more glycans, wherein each of the one or more glycans is conjugated with the carrier through a linker, and optionally (b) an adjuvant. The one or more glycan is each a Globo H... Academia Sinica

Detector for measuring scanning ion beams in radiation therapy

A detector for measuring scanning ion beams in radiation therapy sequentially includes a first high voltage electrode, a first spacing member, and a segmented electrode. The first spacing member is connected to the first high voltage electrode and the segmented electrode to form a first ionization cavity. The first ionization... Academia Sinica

Bidens pilosa and polyacetylenic compounds for prevention and treatment of coccidiosis

A composition for use in prevention, inhibition and/or treatment of coccidiosis in an animal is disclosed. The composition comprises an effective amount of Bidens pilosa, an active constituent thereof, or an active compound isolated therefrom. In another aspect, a composition for use in enhancing growth in an animal is disclosed.... Academia Sinica

08/17/17 / #20170233658

Batch-process supertorrefaction system and method

A compact, transportable batch-process supertorrefaction system includes at least one supertorrefying unit, a liquid tank containing molten salt, and a wash tank including a plurality of basins containing water having different temperatures and different salinity. The liquid tank and the wash tank sequentially supply the molten salt and the water... Academia Sinica

08/10/17 / #20170224716

Methods and compositions for treating pain

The invention provides a new use of adenosine analogs for the treatment of pain through activation of neurokinin 1 (NK1) receptor signaling pathway, thereby inducing the activation of activation of M-type potassium channel to induce outward currents. A method and pharmaceutical composition for treating pain comprising an adenonsine analog that... Academia Sinica

08/10/17 / #20170226169

Bipartite molecules and uses thereof in treating diseases associated with abnormal protein aggregates

Bipartite molecules comprising a peptide affinity moiety and at least one charged moiety and uses thereof in reducing formation of abnormal protein aggregate and treating diseases associated with such abnormal protein aggregate, including neurodegenerative disease characterized by formation of protein aggregates.... Academia Sinica

08/10/17 / #20170229652

Organic electroluminescent material containing alkaline earth metal based metal-organic frameworks and organic electroluminescent device using the same

wherein x is between 1 and 4, y is between 1 and 8, and n is a positive integer. M is any one selected from the group consisting of beryllium (Be), strontium (Sr), and radium (Ra). L is an organic ligand containing a naphthalene group and an anhydride group. M... Academia Sinica

08/10/17 / #20170229703

Method of preparation a battery electrode by spray coating, an electrode and a battery made by method thereof

The present invention provides a method of preparing a battery electrode, comprising: (a) providing electroactive particles; (b) mixing the electroactive particles with a graphene-based material to form a composite; and (c) spray coating the composite onto a substrate to form the battery electrode; wherein the percentage of the electroactive particles... Academia Sinica

08/03/17 / #20170218369

An antagonistic pd-1 aptamer and its applications in cancer therapy related applications

Aptamers that bind to and antagonize PD-1 and uses thereof in promoting T cell proliferation, treating cancer or infectious diseases such as HIV infection.... Academia Sinica

08/03/17 / #20170219593

Methods and systems for cancer diagnosis and prognosis

The disclosure provides for compositions and methods of making and using a foam composition and its utility in clinical applications.... Academia Sinica

07/27/17 / #20170211067

Antagonistic ctla-4 aptamers and applications thereof in enhancing immune activity

Aptamers that bind to and inhibit CTLA-4 and uses thereof in enhancing immune activities, and treating cancer and HIV infection are provided.... Academia Sinica

07/27/17 / #20170215041

Building design information based indoor positioning system

An indoor positioning system based on building design information is disclosed. The system includes a server computer to provide indoor position information relating to a building, a plurality of beacons to be installed in selected locations in the building and to broadcast by each beacon an indoor position message indicating... Academia Sinica

07/13/17 / #20170199184

Capture, purification, and release of biological substances using a surface coating

This invention relates to a surface coating for capture circulating rare cells, comprising a nonfouling composition to prevent the binding of non-specific cells and adsorption of serum components; a bioactive composition for binding the biological substance, such as circulating tumor cells; with or without a linker composition that binds the... Academia Sinica

06/29/17 / #20170182001

Novel sesquiterpene derivatives and their use in inflammation or cancer treatment

A new class of sesquiterpene derivative useful for treating cancerous and inflammatory diseases are disclosed. These deoxyelephantopin derivatives are effective in suppressing proliferation, migration, mobility, invasion, growth, and/or metastasis of cancer cells in a patient, or useful for enhancing an anti-proliferative effect of another anti-cancer drug on cancer cells when... Academia Sinica

06/29/17 / #20170183660

Aptamer targeting mage-a3 peptide and uses thereof

Disclosed herein is an aptamer targeting a MHC-presented peptide and its uses thereof. The MHC-presented peptide is expressed in various cancer cells; therefor, the aptamer of the disclosure is useful as a bio-tool to label and/or treat peptide-presenting cancer cells. Also disclosed herein is a pharmaceutical composition containing the aptamer.... Academia Sinica

06/22/17 / #20170173154

Multi-drug delivery system and use thereof

Disclosed herein is a multiple drugs delivery system and its uses in treating diseases. The multiple drugs delivery system includes, an anti-PEG antibody for directing the PEGylated therapeutic to the treatment site; and a hydrogel for retaining the anti-PEG antibody and/or the PEGylated therapeutic at the treatment site for at... Academia Sinica

06/08/17 / #20170159051

Small interfering rna and pharmaceutical composition and inhibiting galectin-12 expression and/or enhancing lipolysis containing the same

A small interfering RNA is provided. The small interfering RNA consists of a passenger strand and a guide strand, wherein the sequence of the passenger strand comprises the sequence of SEQ ID NO. 7, and the sequence of the guide strand comprises the sequence of SEQ ID NO. 8, wherein... Academia Sinica

06/01/17 / #20170153195

Method and device for detecting charged particles

Disclosed herein is a device for the detection of charged particles of a sample material. The device includes at least, a charge stripping means disposed in a first electric field, and a detection electrode disposed in a second electric field. The charge stripping means may neutralize or strip the charges... Academia Sinica

06/01/17 / #20170153250

Diagnosis and treatment of kawasaki disease

Described is a method of diagnosing, treating, or monitoring a treatment for Kawasaki disease in a subject. The method includes detecting the level of a biomarker in a sample obtained from the subject, the biomarker being IL-7F, sCD40L, MPIF-1, E-selectin, IP-10, or IL-33. The level is compared to a cut-off... Academia Sinica

05/18/17 / #20170137792

Recombinant polynucleotide sequence for producing astaxanthin and uses thereof

Disclosed herein are recombinant polynucleotide sequences, vectors, host cells and methods for producing astaxanthin. The recombinant polynucleotide sequence is designed to provide a higher level of astaxanthin precursors via a shorter metabolic pathway, and thereby attains higher level of end products (e.g., astaxanthin) with desired stereoisomeric form and/or esterified form.... Academia Sinica

05/04/17 / #20170121425

Humanized anti-ige antibodies that crosslink cd23 on b lymphocytes but do not sensitize mast cells

A novel humanized anti-IgE antibody is disclosed. The antibody is capable of binding to free IgE, membrane-bound IgE on B lymphocytes, IgE bound by CD23, but not to IgE bound by high-affinity IgE.Fc receptor on mast cells. The present invention relates to the treatment of IgE-mediated diseases, including allergic asthma,... Academia Sinica

04/13/17 / #20170102387

Zanamivir phosphonate congeners with anti-influenza activity and determining oseltamivir susceptibility of influenza viruses

Methods and compositions for detection of drug resistant pathogens and treatment against infections thereof are provided. Methods for detection of oseltamivir-resistant influenza viruses by competitive binding assays utilizing non-oseltamivir influenza virus neuraminidase inhibitors and oseltamivir carboxylate are provided. Influenza virus neuraminidase inhibitors coupled to sensors and useful for employment in... Academia Sinica

03/23/17 / #20170081632

Composition and controlling insects and microorganims using pseudomonas taiwanensis

Described herein are method and compositions for controlling insects and microorganisms growth using Pseudomonas taiwanensis and its culture broth.... Academia Sinica

03/23/17 / #20170082909

Supercontinuum generation apparatus and method

Apparatuses and methods for supercontinuum generation using a laser beam and a plurality of condensed state transparent plates are presented. As an example, plate material to be used for one of the plurality of plates is determined. A thickness of the one of the plurality of plates is also determined.... Academia Sinica

03/09/17 / #20170068214

Plasmonic multicolor meta-hologram

A phase-modulated optical component for the visible spectrum is provided and is capable of producing images in three primary colors. The phase-modulated optical component is primarily structured by a plurality of aluminum nanorods that are arranged in several two-dimensional arrays to form a plurality of pixels. The nanorods can yield... Academia Sinica

03/02/17 / #20170056523

Bi-specific antibodies and uses thereof

Disclosed herein is a bi-specific antibody that specifically directs a therapeutic agent to a cancer cell by targeting a tumor antigen of the cancer cell, and thereby suppresses the growth of the cancer or blocking the invasion or metastasis of the cancer. The bi-specific antibody of the present disclosure includes... Academia Sinica

02/23/17 / #20170049794

Pdia4 protein as a target for diagnosis, monitoring and treatment of diabetes

A Pdia4 inhibitor for use in preventing, alleviating and/or treating diabetes and/or diabetes-related complications in a subject in need thereof is disclosed, wherein the Pdia4 inhibitor does not comprise cytopiloyene. A Pdia4 inhibitor and one other anti-diabetic agent for use in combination therapy in preventing, alleviating, treating diabetes and diabetes-related... Academia Sinica

02/23/17 / #20170050922
02/23/17 / #20170051038

Recombinant decoy receptor 3 for treating spinal cord injury

Disclosed herein are methods for treating spinal cord injury using recombinant decoy receptor 3 (DcR3) polypeptide. Also disclosed herein are methods for improving the locomotor function recovery of a spinal cord injured subject with a DcR3 polypeptide.... Academia Sinica

02/16/17 / #20170044239

Phage-displayed antibody libraries and uses thereof

Disclosed herein are phage-displayed single-chain variable fragment (scFv) libraries, which comprised a plurality of scFvs with a specific sequence in each CDR. The present scFv libraries could be used to efficiently produce different antibodies with high binding affinity to H1 hemagglutinin of influenza virus. Accordingly, the present disclosure provides a... Academia Sinica

02/09/17 / #20170038378

Glycan arrays on ptfe-like aluminum coated glass slides and related methods

Aluminum coated glass slides provide a novel glycan array platform. Specifically, aluminum coated glass slides increase sensitivity of fluorescent based assay methods. Additionally, aluminum coated glass slides allows for mass spectroscopic analysis of carbohydrates and provide a platform for examining activity of cellulases. The unique properties of ACG slides include:... Academia Sinica

01/19/17 / #20170016011

Method for high efficiency protein delivery into plastids

The present invention provides a recombinant DNA molecule encoding a fusion protein, comprising a first DNA sequence encoding a high-efficiency transit peptide operably linked to a second DNA sequence encoding a passenger protein, wherein the high-efficiency transit peptide is selected from the group consisting of transit peptides of the precursors... Academia Sinica








ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009



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