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Academisch Ziekenhuis Leiden
Academisch Ziekenhuis Leiden H o d n Lumc
Academisch Ziekenhuis Leiden H o d n
Academisch Ziekenhuis Leiden A u Leiden Uni Medical Ctr
Academisch Ziekenhuis Leiden A u Leiden University Medical Center
Academisch Ziekenhuis Leiden H o d n Lucm
Academisch Ziekenhuis Leiden also Acting Under The Name Of Leiden University Medical
Academisch Ziekenhuis Leiden H o d n Leids Universitair Medisch Centrum

Academisch Ziekenhuis Leiden patents


Recent patent applications related to Academisch Ziekenhuis Leiden. Academisch Ziekenhuis Leiden is listed as an Agent/Assignee. Note: Academisch Ziekenhuis Leiden may have other listings under different names/spellings. We're not affiliated with Academisch Ziekenhuis Leiden, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "A" | Academisch Ziekenhuis Leiden-related inventors


Long peptides of 22-45 amino acid residues that induce and/or enhance antigen specific immune responses

Epitopes derived from human papilloma virus and peptides having a size of about 22-45 amino acid residues comprising minimal T cell epitopes are disclosed. Also disclosed are clinically relevant approaches for immunizing subjects against (Myco) bacterially and/or virally infected cells or tumor cells. Peptide sequences of 22-35 amino acid residues... Academisch Ziekenhuis Leiden

Methods of inducing exon skipping

Oligonucleotides for inducing exon skipping, including exon 51 of the dystrophin gene. Compositions are disclosed for treating Duchenne Muscular Dystrophy. Disclosed structures include: (1) h51AON1 (SEQ ID NO: 27; UCAA GGAA GAUG GCAU UUCU), which is 20 bases long, (2) h51AON2 (SEQ ID NO: 28; CCUC UGUG AUUU UAUA ACUU... Academisch Ziekenhuis Leiden

Methods of inducing exon skipping

Methods for inducing skipping of exons, including exon 51 of the dystrophin gene. Oligonucleotides are used for inducing exon skipping and for treating Duchenne Muscular Dystrophy. Disclosed structures include: (1) h51AON1 (SEQ ID NO: 27; UCAA GGAA GAUG GCAU UUCU), which is 20 bases long, (2) h51AON2 (SEQ ID NO:... Academisch Ziekenhuis Leiden

Genetic attenuation of plasmodium by b9 gene disruption

Disclosed herein are mutant Plasmodium-species parasites that are genetically attenuated (GAP). They retain the ability to infect a host and invade host hepatocytes but subsequently their development is completely arrested within the liver stage of Plasmodium development and the parasites do not reach the blood stage of development. Vaccines and... Academisch Ziekenhuis Leiden

A magnetic resonance apparatus comprising a plasma antenna

A magnetic resonance apparatus comprising: a magnetic system configured to provide a magnetic field throughout at least a portion of a cavity, the magnetic field based on magnetic-system-control-data; a transmitter antenna disposed at least partly within the cavity and configured to transmit radio-frequency-transmitted-signalling based on transmitter-control-data; and a receiver antenna... Academisch Ziekenhuis Leiden

Anti-carbamylated protein antibodies and the risk for arthritis

Antibodies against citrullinated protein antigens (ACPA) have shown their relevance for the diagnosis and possibly pathogenesis in arthritis. Described are means and methods for determining antibodies against homocitrulline-containing proteins or carbamylated proteins/peptides (anti-CarP) for the classification of individuals suffering from, or at risk of suffering from, arthritis.... Academisch Ziekenhuis Leiden

Prohemostatic proteins for the treatment of bleeding

This disclosure relates to recombinant FXa polypeptides that can be used as antidotes to completely or partially reverse an anti-coagulant effect of a coagulation inhibitor in a subject, preferably a direct factor Xa inhibitor. Disclosed herein are recombinant factor Xa proteins and a method of completely or partially reversing an... Academisch Ziekenhuis Leiden

In situ tissue engineering

The present disclosure relates to in situ tissue engineering, more specifically in situ vascular tissue engineering with the aim of providing a tissue structure which can be used e.g. as a substitute blood vessel or as a blood vessel functioning as cannulation site in hemodialysis. In particular, the disclosure involves... Academisch Ziekenhuis Leiden

Methods and means for efficient skipping of exon 45 in duchenne muscular dystrophy pre-mrna

The invention relates to a method for inducing or promoting skipping of exon 45 of DMD pre-mRNA in a Duchenne Muscular Dystrophy patient, preferably in an isolated (muscle) cell, the method comprising providing an isolate muscle cell with a molecule that binds to a continuous stretch of at least 21... Academisch Ziekenhuis Leiden

Methods and means for efficient skipping of at least one of the following exons of the human duchenne muscular dystrophy gene: 43, 46, 50-53

The invention relates a method wherein a molecule is used for inducing and/or promoting skipping of at least one of exon 43, exon 46, exons 50-53 of the DMD pre-mRNA in a patient, preferably in an isolated cell of a patient, the method comprising providing said cell and/or said patient... Academisch Ziekenhuis Leiden

Hpv epitopes targeted by t cells infiltrating cervical malignancies for use in vaccines

The present invention relates to novel CD4+ and CD8+ T cell epitopes that are specific for HPV-specific E6 and E7 oncoproteins, to peptides comprising these novel T cell epitopes, and to (vaccine) compositions comprising these peptides for use in methods for the prevention and/or treatment of HPV related diseases. Preferred... Academisch Ziekenhuis Leiden

Cd94/nkg2a and/or cd94/nkg2b antibody, vaccine combinations

The disclosure provides among others a combination of a vaccine and a CD94/NKG2A and/or a CD94/NKG2B binding antibody for use in the treatment of a subject in need thereof, wherein said vaccine comprises an immunogen for eliciting an immune response against an antigen or a nucleic acid molecule encoding said... Academisch Ziekenhuis Leiden

Anti-carbamylated protein antibodies and the risk for arthritis

Antibodies against citrullinated protein antigens (ACPA) have shown their relevance for the diagnosis and possibly pathogenesis in arthritis. Described are means and methods for determining antibodies against homocitrulline-containing proteins or carbamylated proteins/peptides (anti-CarP) for the classification of individuals suffering from, or at risk of suffering from, arthritis.... Academisch Ziekenhuis Leiden

Antisense oligonucleotide directed removal of proteolytic cleavage sites, the hchwa-d mutation, and trinucleotide repeat expansions

Described are methods for removing a proteolytic cleavage site, the HCHWA-D mutation or the amino acids encoded by a trinucleotide repeat expansion from a protein comprising providing a cell that expresses pre-mRNA encoding the protein with an anti-sense oligonucleotide that induces skipping of the exonic sequence that comprises the proteolytic... Academisch Ziekenhuis Leiden

Antisense oligonucleotide directed removal of proteolytic cleavage sites from proteins

The invention relates to means and methods for removing a proteolytic cleavage site from a protein comprising providing a cell that expresses pre-mRNA encoding the protein with an anti-sense oligonucleotide that induces skipping of the exonic sequence that encodes the proteolytic cleavage site, the method further comprising allowing translation of... Academisch Ziekenhuis Leiden

Intradermal hpv peptide vaccination

The invention relates to the use of a peptide derived from HPV-E2, -E6 and/or E7 protein for the manufacture of a medicament for the treatment or prevention of an HPV related disease, wherein the medicament is for interdermal administration.... Academisch Ziekenhuis Leiden

Vascular re-modelling

The present invention is based on the finding that microRNA from the microRNA gene cluster located on the human chromosomal at locus 14q32 play an important role in vascular development and re-modelling. Modulators of any of the 14q32 microRNA may be exploited as a means to modulate vascular re-modelling processes... Academisch Ziekenhuis Leiden

R2r1/2 in diagnosis and therapy

The present invention stems from the finding that two genes designated R2R1 and R2R2, play important roles in tissue development and cancer biology. In particular, the inventors have discovered that these two genes are expressed in pulmonary cells and are required for late branching morphogenesis of pulmonary epithelium and endothelium... Academisch Ziekenhuis Leiden








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