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Acea Biosciences Inc patents


Recent patent applications related to Acea Biosciences Inc. Acea Biosciences Inc is listed as an Agent/Assignee. Note: Acea Biosciences Inc may have other listings under different names/spellings. We're not affiliated with Acea Biosciences Inc, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "A" | Acea Biosciences Inc-related inventors


Methods of collecting cells from multi-well plates for use in flow cytometry

A method of collecting cells from individual wells of a multi-well plate for flow cytometry, the method comprising: determining particle or cell counts from each well of the multi-well plate by flow cytometry; ordering the wells from lowest particle count to highest particle count; generating a sequential order for collection that follows the ordering of wells to establish a collection pattern; and collecting particles or cells according to the collection pattern in a second multi-well plate by flow cytometry.. . ... Acea Biosciences Inc

Label-free monitoring of excitation-contraction coupling and excitable cells using impedance based systems with millisecond time resolution

A system for monitoring impedance of excitable cells in vitro, which includes a device for monitoring cell-substrate impedance at 20 millisecond resolution, which includes a nonconductive substrate with one or more electrode arrays fabricated in one or more wells, wherein cell attachment on the substrate can result in a detectable change in impedance between electrodes within each electrode array; an impedance analyzer capable of impedance measurement at 20 millisecond time resolution; electronic circuitry that can engage said device and selectively connect said two or more electrode arrays of said device to said impedance analyzer; and a software program that controls said electronic circuitry and records and analyzes data obtained from said impedance analyzer.. . ... Acea Biosciences Inc

Novel egfr modulators and uses thereof

The present invention relates to certain pyrrolopyrimidine derivatives, pharmaceutical compositions containing them, and methods of using them, including methods for the treatment of tumors and related diseases related to the dysregulation of kinase (such as egfr (including her), alk, pdgfr, but not limited to) pathways.. . ... Acea Biosciences Inc

Dynamic monitoring of receptor tyrosine kinase (rtk) activity and pathways in living cells using real-time microelectronic cell sensing technology

A method of identifying a potential therapeutic compound that affects a receptor tyrosine kinase (rtk) pathway in cancer cells, which includes: providing a device capable of measuring cell-substrate impedance; culturing cancer cells in serum-free media in at least two wells of the device; adding to a first well a proposed therapeutic compound that affects a rtk pathway and a rtk stimulating factor for the rtk pathway to form a test well, and adding to another well the rtk stimulating factor to form a control well; continuously monitoring cell-substrate impedance of the at least two wells and optionally determining cell indices from the monitored cell-substrate impedance; and determining a difference in impedance or optionally cell index between the test well and control well; and if significantly different, concluding the proposed therapeutic compound is therapeutically active in the rtk pathway within the cancer cells.. . ... Acea Biosciences Inc

Using impedance-based cell response profiling to identify putative inhibitors for oncogene addicted targets or pathways

Methods of identifying whether a biologically active agent affects an oncogene addicted pathway within a cancer cell, by introducing a biologically active agent suspected of affecting an oncogene addicted pathway to a first well and a negative control to a second well, and introducing a stimulating agent that stimulates the oncogene addicted pathway to both wells; monitoring cell-substrate impedance of the two wells and optionally determining cell indices from impedance values; generating an impedance based curve for each of the two wells from the impedance values or from the cell indices; comparing the impedance-based curves to determine a degree of similarity; and if significantly different concluding the biologically active agent affects the oncogene addicted pathway within the cancer cells.. . ... Acea Biosciences Inc

Novel pyrrolopyrimidine compounds as inhibitors of protein kinases

The present invention relates to certain pyrrolopyrimidine derivatives, pharmaceutical compositions containing them, and methods of using them, including methods for the treatment of proliferation disorders and other diseases related to the dysregulation of kinase (such as, but not limited to, egfr (including her), alk, pdgfr, blk, bmx/etk, btk, flt3(d835y), itk, jak1, jak2, jak3, tec and txk) and/or the respective pathways.. . ... Acea Biosciences Inc

Data analysis of cells undergoing excitation contraction coupling as detected on real-time cell analysis (rtca) instruments

A method of determining a beating parameter of cells that undergo excitation contraction coupling, the method including providing a cell analysis device having a substrate and a sensor that measures cell adhesion or attachment to the substrate in millisecond time resolution; adding excitable cells capable of undergoing excitation contraction coupling to the substrate; monitoring cell adhesion or attachment of the excitable cells to the substrate in millisecond time resolution; and calculating one or more beating parameters from the monitored adhesion.. . ... Acea Biosciences Inc

Optical engine for flow cytometer, flow cytometer system and methods of use

An optical engine for use in a bench top flow cytometer, the optical engine comprising a set of lasers; a different set of beam shaping optics for each laser, wherein each set comprises two lenses to adjustably focus light horizontally along an x-axis to a same horizontal position and vertically along a y-axis to a different vertical position along a same plane; collection optics for collecting fluorescence from the flow cell; filtration optics that filter the collected fluorescence from the flow cell into different detection channels according to wavelength ranges; and a detector for each detection channel that converts the filtered fluorescence to electrical signals, wherein electrical signals are processed so that the fluorescence from each laser at the different vertical positions is distinguished at the same detector.. . ... Acea Biosciences Inc

System and method for detecting multiple-excitation-induced light in a flow channel

A system for detecting signal components of light induced by multiple excitation sources, which includes a flow channel having two spatially separated optical interrogation zones; a light illumination subsystem that directs each of two light beams of different wavelengths to a different zone of the optical interrogation zones; a detector subsystem that converts detected light into a total electrical signal having both modulated and unmodulated electrical signals; and a processor that determines signal components from the light detected from each of the optical interrogation zones.. . ... Acea Biosciences Inc

Heterocyclic compounds and uses thereof

The present invention relates to pharmaceutical compounds, compositions and methods, especially as they are related to compositions and methods for the treatment and/or prevention of a proliferation disorder, a cancer, a tumor, an inflammatory disease, an autoimmune disease, psoriasis, dry eye or an immunologically related disease, and in some embodiments diseases or disorders related to the dysregulation of kinase such as, but not limited to, egfr (including her), alk, pdgfr, blk, bmx/etk, flt3(d835y), itk, tec, txk, btk, or jak, and the respective pathways.. . ... Acea Biosciences Inc








ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009



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