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Adaptive Biotechnologies Corp
Adaptive Biotechnologies Corporation

Adaptive Biotechnologies Corp patents


Recent patent applications related to Adaptive Biotechnologies Corp. Adaptive Biotechnologies Corp is listed as an Agent/Assignee. Note: Adaptive Biotechnologies Corp may have other listings under different names/spellings. We're not affiliated with Adaptive Biotechnologies Corp, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "A" | Adaptive Biotechnologies Corp-related inventors


Characterization of adaptive immune response to vaccination or infection using immunosequencing

Methods of monitoring and measuring dynamic adaptive immune cell responses are provided. High-throughput sequencing of T cell receptor and immunoglobulin loci is used to characterize the breadth of an effector cell response to a stimulus, such as a vaccine or infection. Unique responding effector cell clones and abundance thereof can... Adaptive Biotechnologies Corp

Highly-multiplexed simultaneous detection of nucleic acids encoding paired adaptive immune receptor heterodimers from a large number of samples

The invention is directed to methods for highly-multiplexed simultaneous detection of nucleic acids encoding paired adaptive immune heterodimers from a large number of biological samples containing lymphocytes of interest. Methods of the invention comprise performing a single pairing assay on a pool of source samples to determine nucleic acids encoding... Adaptive Biotechnologies Corp

Methods using randomer-containing synthetic molecules

Methods are provided for correction of amplification bias and quantitation of adaptive immune cells in a sample using synthetic templates that include random oligonucleotide sequences.... Adaptive Biotechnologies Corp

T-cell receptor clonotypes shared among ankylosing spondylitis patients

The invention includes a method for determining the disease status of an individual suffering from ankylosing spondylitis by monitoring the individual's T-cell repertoire for the presence and/or level of clonotypes encoding T-cell receptor chains with segments identical to ant or related to the peptide LCASSLEASGSSYNEQFFGPGTRLTV (SEQ ID NO: 1) or... Adaptive Biotechnologies Corp

Quantification of adaptive immune cell genomes in a complex mixture of cells

A relative representation of adaptive immune cells in a biological sample is quantified using multiplex PCR and sequencing of adaptive immune cells, control genes, and synthetic template molecules. Disclosed herein are methods for quantifying a number of adaptive immune cells in a biological sample, and methods for quantifying a relative... Adaptive Biotechnologies Corp

Determining antigen-specific t-cells

The invention is directed to methods for determining antigen-specific T cells. In some embodiments, methods of the invention may be implemented by the steps of reacting under interaction conditions one or more antigens with T cells in a plurality of subsets of a tissue sample, such as peripheral blood; sorting... Adaptive Biotechnologies Corp

Method of identifying human compatible t cell receptors specific for an antigenic target

Methods are provided for identifying T cell receptors that specifically bind a particular antigenic target and can be used as therapeutics against disease.... Adaptive Biotechnologies Corp

Monitoring health and disease status using clonotype profiles

There is a need for improved methods for determining the diagnosis and prognosis of patients with conditions, including autoimmune disease and cancer, especially lymphoid neoplasms, such as lymphomas and leukemias. Provided herein are methods for using DNA sequencing to identify personalized, or patient-specific biomarkers in patients with lymphoid neoplasms, autoimmune... Adaptive Biotechnologies Corp

Method for studying v(d)j combinatory diversity

The invention relates to a method for analyzing the diversity of the catalogue of T and/or B lymphocytes in an individual, based on the amplification, from a sample, of genomic DNA fragments by PCR multi-n-plexes, with n≧2, carried out with a combination of at least 3 primers defining at least... Adaptive Biotechnologies Corp

Methods for diagnosing infectious disease and determining hla status using immune repertoire sequencing

Methods are provided for predicting a subject's infection status using high-throughput T cell receptor sequencing to match the subject's TCR repertoire to a known set of disease-associated T cell receptor sequences. The methods of the present invention may be used to predict the status of several infectious agents in a... Adaptive Biotechnologies Corp

Immunocompetence assessment by adaptive immune receptor diversity and clonality characterization

Disclosed are methods for determining the immunological status of the adaptive immune system of a subject by identifying and quantifying rearranged DNA (and/or subsequently transcribed RNA) sequences encoding T cell receptor (TCR) and/or immunoglobulin (IG) polypeptides, in a lymphoid DNA-containing sample from the subject TCR and/or IG sequence diversity and... Adaptive Biotechnologies Corp

Monitoring health and disease status using clonotype profiles

There is a need for improved methods for determining the diagnosis and prognosis of patients with conditions, including autoimmune disease and cancer, especially lymphoid neoplasms, such as lymphomas and leukemias. Provided herein are methods for using DNA sequencing to identify personalized, or patient-specific biomarkers in patients with lymphoid neoplasms, autoimmune... Adaptive Biotechnologies Corp

Method for genotyping clonotype profiles using sequence tags

The invention is directed to sequence-based profiling of populations of nucleic acids by multiplex amplification and attachment of one or more sequence tags to target nucleic acids and/or copies thereof followed by high-throughput sequencing of the amplification product. In some embodiments, the invention includes successive steps of primer extension, removal... Adaptive Biotechnologies Corp








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