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Aduro Biotech Inc patents


Recent patent applications related to Aduro Biotech Inc. Aduro Biotech Inc is listed as an Agent/Assignee. Note: Aduro Biotech Inc may have other listings under different names/spellings. We're not affiliated with Aduro Biotech Inc, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "A" | Aduro Biotech Inc-related inventors


Compositions and methods for activating "stimulator of interferon gene" - dependent signalling

The present invention provides highly active cyclic-di-nucleotide (cdn) immune stimulators that activate dcs via a recently discovered cytoplasmic receptor known as sting (stimulator of interferon genes), in particular, the cdns of the present invention are provided in the form of a composition comprising one or more cyclic purine dinucleotides induce human sting-dependent type i interferon production, wherein the cyclic purine dinucleotides present in the composition are 2′-fluoro substituted, bis-3′,5′cdns, and most preferably one or more 2′,2″-dif-rp,rp, bis-3′,5′cdns.. . ... Aduro Biotech Inc

New anti-hctla-4 antibodies

The invention relates to new anti-hctla-4 antibodies that bind to a different epitope than prior art anti-ctla4 antibodies, methods to produce these antibodies and therapeutic and diagnostic uses of these antibodies. These antibodies show a similar affinity for the ctla4 antigen and they are also able to block the binding of ctla4 to cd80 and/or cd86.. ... Aduro Biotech Inc

Protein expression enhancer sequences and use thereof

The present invention provides nucleic acid and protein sequences that enhance the expression of fusion proteins by host cells, and in particular bacterial species, together with methods use thereof. While described hereinafter in terms of expression of fusion proteins by listeria monocytogenes, the present invention is applicable to expression of fusion proteins generally.. ... Aduro Biotech Inc

Anti-pd-1 antibodies

The present invention relates to anti-pd-1 antibodies, as well as use of these antibodies in the treatment of diseases such as cancer and infectious disease. These antibodies have cdrs as provided in the enclosed sequences. ... Aduro Biotech Inc

Use of sting agonist as cancer treatment

Methods and compositions for treating cancer by intratumorally administering a stimulator of interferon genes (sting) agonist are disclosed herein.. . ... Aduro Biotech Inc

Engineered listeria and methods of use thereof

The invention provides a bacterium containing a polynucleotide comprising a nucleic acid encoding a heterologous antigen, as well as fusion protein partners. Also provided are vectors for mediating site-specific recombination and vectors comprising removable antibiotic resistance genes.. ... Aduro Biotech Inc

Compositions comprising cyclic purine dinucleotides having defined stereochemistries and methods for their preparation and use

It is an object of the present invention to provide novel and highly active cyclic-di-nucleotide (cdn) immune stimulators that activates dcs via a recently discovered cytoplasmic receptor known as sting (stimulator of interferon genes). In particular, the cdns of the present invention are provided in the form of a composition comprising one or more cyclic purine dinucleotides that induce sting-dependent tbk1 activation, wherein the cyclic purine dinuclotides present in the composition are substantially pure rp,rp or rp,sp stereoisomers, and particularly substantially pure rp,rp, or rpsp cdn thiophosphate diastereomers.. ... Aduro Biotech Inc

Agonistic antibody to cd27

The invention relates to a binding compound, which binds the same epitope of human cd27 as monoclonal antibody hcd27.15, produced by hybridoma hcd27.15 which was deposited with the atcc in on jun. 2, 2010 under number pta-11008. ... Aduro Biotech Inc

Signal peptide fusion partners facilitating listerial expression of antigenic sequences and methods of preparation and use thereof

The present invention provides nucleic acids, expression systems, and vaccine strains which provide efficient expression and secretion of antigens of interest into the cytosol of host cells, and elicit effective cd4 and cd8 t cell responses by functionally linking listerial or other bacterial signal peptides/secretion chaperones as n-terminal fusion partners in translational reading frame with selected recombinant encoded protein antigens. These n-terminal fusion partners are deleted (either by actual deletion, by mutation, or by a combination of these approaches) for any pest sequences native to the sequence, and/or for certain hydrophobic residues.. ... Aduro Biotech Inc

Compositions and methods for inhibiting "stimulator of interferon gene" -dependent signalling

The present invention provides cyclic-di-nucleotide (cdn) compounds that inhibit signaling at a recently discovered cytoplasmic receptor known as sting (stimulator of interferon genes). In particular, the cdns of the present invention are provided in the form of a composition comprising one or more cyclic purine dinucleotides which inhibit sting-dependent tbk1 activation and the resulting production of type i interferon.. ... Aduro Biotech Inc

Facultatively attenuated bacterial species and methods of preparation and use thereof

The present invention provides facultatively attenuated bacterial species and methods of preparation and use thereof. The term “facultatively attenuated” as used herein refers to a bacterium which comprises a set of defined recombinant modifications which have substantially no effect on the ability of the bacterium to grow by multiplication when the bacterium is outside of its host organism, but which result in deletion of one or more genes essential for multiplication of the bacterium when the bacterium is introduced into its host organism, for example within host cells of a vaccinate recipient. ... Aduro Biotech Inc








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