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Agilent Technologies Inc
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Agilent Technologies Inc patents


Recent patent applications related to Agilent Technologies Inc. Agilent Technologies Inc is listed as an Agent/Assignee. Note: Agilent Technologies Inc may have other listings under different names/spellings. We're not affiliated with Agilent Technologies Inc, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "A" | Agilent Technologies Inc-related inventors


 new patent  On-array ligation assembly

Provided herein, among other things, is a method for producing a ligation product on a support. In some embodiments, the method may comprise hybridizing a first double-stranded oligonucleotides and a second double-stranded oligonucleotide to a substrate comprising surface-tethered oligonucleotides and ligating the distal ends of the first and second double-stranded... Agilent Technologies Inc

Functionalized support for analytical sample preparation

Aspects of the present disclosure include a solid phase sorbent for preparation of analytical samples. The solid phase sorbent includes particles that are surface modified with an α-cyclodextrin moiety. Also provided is a method of reducing matrix effects in an analytical sample. In some embodiments, the method includes contacting a... Agilent Technologies Inc

Hairpin-mediated amplification method

In some embodiments, the amplification method may comprise producing a reaction mix comprising: a nucleic acid sample, a polymerase, nucleotides, a forward primer that hybridizes to a sequence in the bottom strand of a fragment in the sample, and a reverse primer. The reverse primer has a hairpin structure comprising... Agilent Technologies Inc

Ion transfer device for mass spectrometry

An ion transfer device for transferring ions from one chamber to another, reduced-pressure chamber includes an inlet section and a main capillary section. The inlet section has a lumen and the main capillary section has a bore communicating with the lumen. The inside diameter of the lumen is less than... Agilent Technologies Inc

Hermetic vacuum pump isolation valve

A vacuum pump isolation (VPI) valve is interposed between a vacuum pump and a vacuum chamber. During normal operation of the vacuum pump, the VPI valve is open, allowing fluid communication between the vacuum pump and the vacuum chamber. When the vacuum pump becomes non-operational such as by losing power,... Agilent Technologies Inc

Quick lock connector for connecting a capillary to a fluidic conduit of a fluidic component

A fitting for providing a fluid connection between a capillary and a fluidic conduit of a fluidic component, wherein the fitting comprises a capillary reception configured for receiving the capillary, a force applicator configured for being operable to apply a fixing force for fixing the capillary within the fitting, a... Agilent Technologies Inc

System and facilitating manual sorting of objects

An apparatus that facilitates the manual sorting of objects is disclosed. The apparatus includes a display surface having a surface that can be selectively illuminated and that is adapted for receiving the objects. An identification reader reads identification information stored on the objects. A controller causes an area on the... Agilent Technologies Inc

Guide rna with chemical modifications

The present invention relates to modified guide RNAs and their use in clustered, regularly interspaced, short palindromic repeats (CRISPR)/CRISPR-associated (Cas) systems.... Agilent Technologies Inc

Artifact compensation due to different properties of fluid accommodation volumes in sample separation apparatus

A control device for controlling at least part of a sample separation apparatus for separating a fluidic sample, the sample separation apparatus including at least two fluid accommodation volumes having different flow through properties and each being configured for temporarily accommodating fluidic sample, wherein the control device is configured for... Agilent Technologies Inc

In-source collision-induced heating and activation of gas-phase ions for spectrometry

An electrode assembly is provided in a high sub-atmospheric pressure region of an ion source, between an ionization chamber and a vacuum region of a spectrometer, such as a mass spectrometer, an ion mobility spectrometer, or an ion mobility-mass spectrometer. The electrode assembly is spaced at a distance from an... Agilent Technologies Inc

Tri-color probes for detecting multiple gene rearrangements in a fish assay

A probe system is provided. In some embodiments, the probe system may comprise: a first labeled probe that hybridizes to one side of a potential translocation breakpoint in a first locus; a second labeled probe that hybridizes to the other side of the potential translocation breakpoint in the first locus;... Agilent Technologies Inc

Impact centrifugal separator and associated methods for fraction collection in supercritical fluid systems

A separator (e.g. an impact centrifugal separator) is for use in collection of liquid portions of a bi-phasic flowstream in a supercritical fluid system. A separator chamber defines an interior space, surrounded by a spiral channel and that has an exit at a lower portion of the separator chamber. A... Agilent Technologies Inc

High specificity genome editing using chemically modified guide rnas

The present invention relates to guide RNAs having chemical modifications and their use in CRISPR-Cas systems. The chemically modified guide RNAs have enhanced specificity for target polynucleotide sequences. The present invention also relates to methods of using chemically modified guide RNAs for cleaving or nicking polynucleotides, and for high specificity... Agilent Technologies Inc

Functionalized particles having modified phases

Modified silica particles are provided. Aspects of the particles include an outer layer that is composed of organically-modified silica comprising a siloxane-linked hydrophilic group, such as a charged functional group or a polar neutral functional group. The modified silica particles can form the basis of a variety of chromatography support... Agilent Technologies Inc

Transposase-random priming dna sample preparation

Provided herein, among other things, are a variety of methods for transposase-mediated tagging and amplification of short DNA fragments, e.g., between about 150 bp and 1.5 Kb in length. In some aspects, the method includes tagging the DNA fragments with a first primer sequence using barcoded transposases followed by a... Agilent Technologies Inc

Flow meters, flow meter cartridges, and related methods

A flow meter for measuring a flow rate of a fluid may include a cartridge containing certain components such as a flow sensor. The cartridge is removable from the flow meter such that it may be replaced with a new cartridge, allowing calibration of the flow meter while enabling the... Agilent Technologies Inc

Optical emission system including dichroic beam combiner

An optical emission spectrometer system includes a light source and a dichroic beam combiner. The light source emits first light in a first direction and second light in a second direction different from the first direction. The dichroic beam combiner receives the first light via a first light path and... Agilent Technologies Inc

Sample injection with fluidic connection between fluid drive unit and sample accommodation volume

An injector, for injecting a fluidic sample into a flow path between a fluid drive and a sample separation unit, includes a sample accommodation volume, a sample drive, and a fluidic valve switchable to selectively couple the volume with the flow path or decouple the volume from the flow path.... Agilent Technologies Inc

Branching off fluidic sample with low influence on source flow path

A sample management device which comprises a source flow path in which a fluidic sample can flow, a volume flow adjustment unit configured to adjust a volume flow of the fluidic sample to be branched off from the source flow path at a fluidic coupling point, and a fluidic valve... Agilent Technologies Inc

Ion throughput pump and method

An ion throughput pump (ITP) includes a pump inlet configured to communicate with a vacuum chamber; an ionization source fluidly communicating with the vacuum chamber via the pump inlet and configured for ionizing gas species received from the vacuum chamber; a pump outlet; ion optics configured for accelerating ions produced... Agilent Technologies Inc

Systems and methods for transferring liquids

One or more liquids are transferred from a source array to one or more remotely positioned destination sites such as chambers by utilizing one or more movable transfer elements, such as contact pins or capillaries. The source array may include a predetermined organization of addresses at which materials are positioned.... Agilent Technologies Inc

Method for enhancing electrospray

Provided herein, among other things, is a method of ionizing a first stream of liquid by an electrospray ion source having a nebulizer, wherein the first stream of liquid may comprise an analyte. In some embodiments, the method may comprise: a) providing the first stream of liquid to the nebulizer;... Agilent Technologies Inc

Metering device with defined enabled flow direction

A sample injector configured to introduce a sample fluid into a mobile phase, wherein the mobile phase is to be driven by a mobile phase drive through a separation unit for separating compounds of the sample fluid in the mobile phase, wherein the sample injector comprises a metering device being... Agilent Technologies Inc

Wideband isolation directed by ion mobility separation for analyzing compounds

In an ion mobility-mass spectrometry (IM-MS) system, an ion mass-isolated data set is acquired by operating a mass filter to apply a mass isolation window having an m/z width such that the mass isolation window moves through a sequence of window positions, each window position being defined by an IM... Agilent Technologies Inc

Augmented reality slide sorter

The present invention includes an apparatus and method that facilitates the manual sorting of slides into slide folders. The apparatus includes a horizontal display surface and a controller configured to receive slides and folders into which the slides are to be placed (or sorted). The controller operates components of the... Agilent Technologies Inc

Superficially porous particles with dual pore structure and methods for making the same

Superficially porous particles are provided. Aspects of the superficially porous particles include a non-porous inner core and a porous outer shell that includes inner and outer porous regions. The inner porous region can include ordered cylindrical pores substantially perpendicular to the non-porous inner core. The outer porous region can include... Agilent Technologies Inc

Use of transposase and y adapters to fragment and tag dna

Described herein, among other things, is an adapter comprising a population of first oligonucleotides, a second oligonucleotide and a third oligonucleotide, wherein the first oligonucleotides, the second oligonucleotide and the third oligonucleotide are hybridized together to produce a complex that comprises: (i) a first end comprising a transposase recognition sequence,... Agilent Technologies Inc

Apparatus and methods for transferring a tissue section

This invention relates to apparatus and methods for automated tissue sectioning, including slicing and transferring a tissue section from a microtome. The invention also relates to automated systems and methods for slicing and transferring a tissue section onto a slide.... Agilent Technologies Inc

Sample injector with metering device balancing pressure differences in an intermediate valve state

A sample injector for use in a fluid separation system for separating compounds of a fluidic sample in a mobile phase, the sample injector comprising a switchable valve, a sample loop in fluid communication with the valve and configured for receiving the fluidic sample, a metering device in fluid communication... Agilent Technologies Inc

Immunohistochemistry scoring methods and compositions

Aspects of the present disclosure provide methods for determining the eligibility of a subject having a malignancy for treatment with an anti-PD therapeutic agent. In certain embodiments, the method includes determining, by immunohistochemistry, the number of PD-L1 positive malignant cells in a tumor tissue section as well as the number... Agilent Technologies Inc

Scoring methods for anti-pd therapy eligibility and compositions for performing same

Aspects of the present disclosure provide methods for determining the eligibility of a subject having a malignancy for treatment with an anti-PD therapeutic agent based on a Combined Positive Score (CPS) for a tumor tissue sample from the subject. Compositions and kits or performing the disclosed methods are also provided.... Agilent Technologies Inc

Filament assembly for generating electrons, and related devices, systems and methods

A filament assembly includes a core and a filament. At least a central portion of the filament is disposed on the core. At least the central portion may be straight or may have a high-resistance configuration such as one in which the filament follows a path that changes direction. A... Agilent Technologies Inc

Methods and compositions for blocking off-target nucleic acids from cleavage by crispr proteins

This invention relates to reagents and methods for increasing specificity and efficiency of genome editing by CRISPR associated (Cas) protein systems, more particularly by Cas:guide RNA complexes, by blocking off-target nucleic acids from cleavage by Cas:guide RNA complexes.... Agilent Technologies Inc

One-pot multiplex gene synthesis

The present invention provides methods for generating a library of synthetic polynucleotides. The present invention also provides methods for generating proteins encoded by the library of synthetic polynucleotides. In addition, provided herein are methods for determining the soluble expression of said proteins. This invention is based, in part, on the... Agilent Technologies Inc

Temporary storage of sample portions for artefact-preventing fluid processing

In a method for processing successive fluidic sample portions provided by a sample source, sample reception volumes are filled successively temporarily with at least a respective one of the sample sections, and the sample sections are emptied successively out of the sample reception volumes in such a way, that, while... Agilent Technologies Inc

08/03/17 / #20170221688

Method for supplying gas for plasma based analytical instrument

To achieve an effective gas filtering in a plasma spectrometric apparatus using a gas of a comparatively high consumption flow rate, and to improve the analytical ability, there is provided a plasma spectrometric apparatus containing a sample introducer for producing and delivering an injector gas containing an analyte sample, a... Agilent Technologies Inc

06/22/17 / #20170175182

Transposase-mediated barcoding of fragmented dna

Provided herein, among other things, are a variety of methods that comprise inserting a plurality of barcoded transposons into a population of DNA fragments that comprise DNA fragments of less than 1 kb in length, to produce transposon-tagged fragments that each comprise a barcoded transposon. Kits for performing this method... Agilent Technologies Inc

05/18/17 / #20170138913

Sealing moving with piston in a high-pressure pump

A piston member for a high-pressure pump for pumping fluid in a sample separation apparatus, wherein the piston member comprises a piston configured for being mountable to reciprocate in a piston chamber for displacing fluid, and a sealing for sealing between the piston member and the piston chamber when the... Agilent Technologies Inc

05/11/17 / #20170130258

Multiplex on-array droplet pcr and quantitative pcr

This present disclosure provides methods and compositions for multiplex amplification, e.g., PCR, of DNA samples compartmentalized on the surface of an array. In certain aspects, the method includes providing a solid substrate having features of immobilized forward and reverse primer pair constructs therein for amplifying a target polynucleotide sequence, contacting... Agilent Technologies Inc

05/11/17 / #20170131244

Secondary stage fluid separation device detachably connectable with primary stage fluid separation device

A secondary stage sample separation device for separating at least a portion of a fluidic sample includes a fluidic interface configured for forming a detachable fluidic coupling between a primary stage sample separation device and the secondary separation device so that the fluidic sample separated by the primary stage sample... Agilent Technologies Inc

05/11/17 / #20170131245

Secondary stage fluid separation device connectable with primary stage fluid separation device

A secondary stage sample separation device for separating at least a portion of a fluidic sample includes a fluidic interface configured for forming a fluidic coupling between a primary stage sample separation device and the secondary separation device, so that the fluidic sample separated by the primary stage sample separation... Agilent Technologies Inc

04/20/17 / #20170107560

Nucleic acid enrichment using cas9

A method of enriching for a fragment of a genome, as well as corresponding compositions and kits, are provided. In certain embodiments, the method comprises: (a) contacting a sample comprising fragmented DNA with a Cas9-gRNA complex comprising mutant Cas9 protein that has inactivated nuclease activity and a Cas9-associated guide RNA... Agilent Technologies Inc

04/20/17 / #20170108140

Fluidic valve with contactless force transmission for pressing together stator and rotor

A fluidic valve for switching between different fluid coupling states includes a stator having at least one fluidic stator interface, a rotor having at least one fluidic rotor interface, wherein the rotor is rotatable relative to the stator to thereby switch the fluidic valve between a plurality of different fluid... Agilent Technologies Inc

04/13/17 / #20170100682

Apparatus and introducing a sample into a separation unit of a chromatography system

An apparatus introduces a sample into a separation unit of a chromatography system with a mobile phase, including first and second mobile phase components. The apparatus includes first and second pump systems, and an injection unit. The first pump system provides the first mobile phase component, first and second portions... Agilent Technologies Inc

04/13/17 / #20170105247

Conical heater assembly for a gas chromatography column

A heating apparatus for a gas chromatography column is described. The GC column heating apparatus includes a conical heater assembly comprising a heating element between an inner layer and an outer layer. The apparatus can also include optionally an outer cowl and/or an inner cowl surrounding the conical heater assembly.... Agilent Technologies Inc

04/06/17 / #20170096999

High pressure seal for a pump system for pumping liquid under high pressure

A system for pumping liquid under high pressure includes a housing and a high pressure seal. The housing houses a pump assembly and a chamber assembly that includes a chamber for containing high pressure liquid. The seal separates high pressure area in the chamber assembly from low pressure area in... Agilent Technologies Inc

03/30/17 / #20170089915

Methods of analyte derivatization and enhanced soft ionization

Methods of analyte derivatization and soft ionization are provided. The methods include contacting a sample including an analyte with a derivatization agent to produce a modified analyte including a pseudo-molecular analyte group and a leaving group connected via a fragmentable bond; and selectively breaking the fragmentable bond under soft ionization... Agilent Technologies Inc

03/30/17 / #20170090439

Interlock system

An implementation of an interlock system disclosed herein provides an interlock system for remotely tracking and controlling usage of a number of equipment. The interlock system disclosed herein includes an interlock module communicatively connected to the equipment and is configured to control the status and monitor usage of such equipment.... Agilent Technologies Inc

03/23/17 / #20170082490

High dynamic range infrared imaging spectroscopy

An imaging scanner and a method for using the same are disclosed. The scanner includes a variable attenuator adapted to receive a light beam generated by a MIR laser and that generates an attenuated light beam therefrom characterized by an attenuation level. The scanner includes an optical assembly that focuses... Agilent Technologies Inc

03/23/17 / #20170082538

Infrared spectrometer and scanner utilizing attenuated total reflection

A scanner and an attenuated total reflection (ATR) objective for use in such scanners are disclosed The ATR objective includes first and second optical elements and an input port. The input port receives an input collimated light beam that is focused to a point on a planar face of the... Agilent Technologies Inc

03/23/17 / #20170085810

Apparatus and three-dimensional infrared imaging of surfaces

A scanner and method for using the same are disclosed. The scanner includes a stage, a MIR light source, an imaging system, and a controller. The stage is adapted to hold a specimen to be imaged and to move the specimen in a first direction and in a second direction... Agilent Technologies Inc

03/09/17 / #20170067103

Polymerase idling single molecule dna sequencing

A method for sequencing a nucleic acid is provided. In certain embodiments the method comprises obtaining a duplex comprising a nucleic acid and a primer, wherein the primer has a nuclease resistant 3′ end, combining the duplex with a chain terminator nucleotide and a proof-reading polymerase to produce a reaction... Agilent Technologies Inc

03/02/17 / #20170058298

Compounds and methods for crispr/cas-based genome editing by homologous recombination

The present invention relates to guide RNAs comprising adaptor segments having one or more modifications, and their use in homologous recombination by CRISPR:Cas systems. The modified adaptor segments are resistant to degradation by RNaseH. The present invention also relates to a dual guide RNA strategy in which a first guide... Agilent Technologies Inc

03/02/17 / #20170058326

Immobilized transposase complexes for dna fragmentation and tagging

The present invention provides a simple and rapid method for preparing purified transposase complexes that are highly suited for fragmenting DNA. The method includes forming transposase complexes with oligonucleotide adapters in cell lysate, then purifying the complexes from the other substance in the cell lysate. Purification is accomplished using a... Agilent Technologies Inc

02/16/17 / #20170044592

Method for fragmenting genomic dna using cas9

A method for fragmenting a genome is provided. In certain embodiments, the method comprises: (a) combining a genomic sample containing genomic DNA with a plurality of Cas9-gRNA complexes, wherein the Cas9-gRNA complexes comprise a Cas9 protein and a set of at least 10 Cas9-associated guide RNAs that are complementary to... Agilent Technologies Inc

02/16/17 / #20170045165

Fitting element with bio-compatible sealing

A fitting element is configured for coupling tubing to a fluidic device having a receiving cavity configured for receiving the fitting element, where the tubing has an inner contact surface of a biocompatible material, the inner contact surface being configured to contact a fluid to be conducted by the tubing,... Agilent Technologies Inc

02/02/17 / #20170033532

Quantum cascade laser with serially configured gain sections

An apparatus that includes a gain chip assembly, an external cavity, and a controller is disclosed. The gain chip assembly includes first and second gain chips that are coupled optically such that light travels serially between the first gain chip and the second gain chip, each gain chip is electrically... Agilent Technologies Inc

01/12/17 / #20170009766

Rigid piston-actuator-assembly supported for performing a pendulum-type tolerance compensation motion

A pump for pumping fluid, wherein the pump includes a working chamber, a piston assembly configured for reciprocating within the working chamber to thereby displace fluid, a piston actuator being rigidly assembled with the piston assembly at least in a working mode of the pump to thereby transmit drive energy... Agilent Technologies Inc

01/05/17 / #20170003166

Infrared imaging system with automatic referencing

A method and apparatus for obtaining reference samples during the generation of a mid-infrared (MW) image without requiring that the sample being imaged be removed is disclosed. A tunable MIR laser generates a light beam that is focused onto a specimen on a specimen stage that moves the specimen in... Agilent Technologies Inc

01/05/17 / #20170003170

Light source with controllable linear polarization

A light source having first and second wire-grid polarizers and a laser that emits a beam of linearly polarized light that is characterized by a propagation direction is disclosed. The first wire-grid polarization filter is characterized by a first linear polarization pass direction and a first actuator for causing the... Agilent Technologies Inc

01/05/17 / #20170003256

Esd protected tubing for removing charge from lumen

An electrostatic discharge protected device for conducting a fluid through at least one lumen includes a tubing having a hollow interior defining the at least one lumen. The tubing includes an electrically conductive section configured for conducting electric charge, generated within the at least one lumen when the fluid flows... Agilent Technologies Inc








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