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Albert Einstein College Of Medicine Inc patents


Recent patent applications related to Albert Einstein College Of Medicine Inc. Albert Einstein College Of Medicine Inc is listed as an Agent/Assignee. Note: Albert Einstein College Of Medicine Inc may have other listings under different names/spellings. We're not affiliated with Albert Einstein College Of Medicine Inc, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "A" | Albert Einstein College Of Medicine Inc-related inventors


 new patent  Monomeric near-infrared fluorescent proteins engineered from bacterial phytochromes and methods for making same

Nucleic acid molecules encoding monomeric near-infrared fluorescent proteins, variants and derivatives thereof are provided, as well as proteins and peptides encoded by these nucleic acids. Also provided are proteins that are substantially similar to, or derivatives, homologues, or mutants of, the above-referenced specific proteins. Also provided are fragments of the... Albert Einstein College Of Medicine Inc

Modified paramagnetic nanoparticles for targeted delivery of therapeutics and methods thereof

Described herein is a method of inducing vascular inflammation using modified paramagnetic nanoparticles with improved therapeutic loading efficiency and enhanced circulation properties. The method comprises loading lipophilic agent into the fatty acid coatings of a paramagnetic nanoparticle (PMNP). In certain embodiment, the lipophilic agent is lipopolysaccharides (LPS). Described herein is... Albert Einstein College Of Medicine Inc

Method for producing radiobacteria for therapy of cancer

A method of producing radiobacteria is provided, especially radiolisteria-32P. Compositions and methods of use thereof are also provided.... Albert Einstein College Of Medicine Inc

Metastasis specific splice variants of mena and uses thereof in diagnosis, prognosis and treatment of tumors

Methods and kits for diagnosis, prognosis and treatment of metastatic tumors are provided where the metastatic tumor is characterized by changes in expression of +++, ++ and/or 11a variants of Mena.... Albert Einstein College Of Medicine Inc

Programmed cargo release using nucleic acid-stabilized micelles

Methods and compositions for serum-stabilizing micelles for drug delivery or imaging agent delivery are provided, as well as methods and compositions to enhance micelle-mediated drug delivery. This invention provides a process for synthesizing a lipid micelle comprising one or more lipid-oligonucleotide conjugate molecules, the process comprising contacting an amount of... Albert Einstein College Of Medicine Inc

Host and intestinal microbiota derived metabolomic blood plasma signature for prior radiation injury

Provided are methods of determining prior radiation dose exposure levels for subjects, and kits therefor. Also provided are methods of treatment.... Albert Einstein College Of Medicine Inc

Methods and compositions for assessing germline risk of cancer

Heritable mutations in the BRCA1 and BRCA2 and other genes in the DNA double-strand break (DSB) repair pathway increase risk of breast, ovarian and other cancers. In response to DNA breaks, the proteins encoded by these genes bind to each other and are transported into the nucleus to form nuclear... Albert Einstein College Of Medicine Inc

Repopulation of organs and tissues using a yap-ert2 fusion protein

Provided herein are methods for the repopulation of organs and tissues, such as the liver, using modified cells that express a transcription coactivation factor-ligand binding domain fusion protein, such as a YAP-ERT2 fusion protein. Also provided are compositions, including nucleic acid molecules that encode a YAP-ERT2 fusion protein, YAP-ERT2 fusion... Albert Einstein College Of Medicine Inc

Recombinant herpes simplex virus 2 (hsv-2) vaccine vectors

Recombinant herpes simplex virus 2 (HSV-2) vaccine vectors, virions thereof, compositions and vaccines comprising such, and methods of use thereof are each provided.... Albert Einstein College Of Medicine Inc

Therapy for filovirus infection

The present invention addresses a need for improved treatments for filovirus infections. This invention provides an isolated humanized anti-filovirus glycoprotein pre-fusion core antibody comprising a framework region having a sequence of 95% or greater identity to a human antibody framework region. Also provided is a method of treating and/or inhibiting... Albert Einstein College Of Medicine Inc

Multi-specific antibodies for cross-neutralization of multiple filovirus glycoproteins

Methods for treating and for preventing Filovirus infections are disclosed, as well as compositions therefor.... Albert Einstein College Of Medicine Inc

Methods and assays for treating hantavirus infections

Methods and assays are disclosed for treating a subject with a hantavirus infection using an agent that binds to proto cadhenn-1 (PCDH1) or inhibits expression of protocadherin-1 (PCDH1).... Albert Einstein College Of Medicine Inc

Tmigd2 and its derivatives as blockers or binders of cancer-expressed hhla2 for immunotherapies

Provided are methods of treating an HHLA2-bearing tumor in a subject with a fusion protein comprising an IgV-like domain of a TMIGD2 sufficient to treat the HHLA2-bearing tumor. A fusion protein comprising an IgV-like domain of a TMIGD2 and related compositions and encoding nucleic acids are also provided.... Albert Einstein College Of Medicine Inc

Cellular platform for rapid and comprehensive t-cell immunomonitoring

Methods and systems for the efficient and systematic identification of the repertoire of T-cell epitopes.... Albert Einstein College Of Medicine Inc

Treatment of h. pylori infections using mtan inhibitors

Methods of treating infections due to Helicobacter pylori (H. pylori), in particular in subjects having a peptic ulcer, are disclosed where the methods comprise administering inhibitors of H. pylori MTAN (5′-methylthioadenosine nucleosidase) to the subject.... Albert Einstein College Of Medicine Inc

3-hydroxypyrrolidine inhibitors of 5'-methylthioadenosine phosphorylase and nucleosidase

The present invention relates to 3-hydroxypyrrolidine compounds of the general formula (1) which are inhibitors of 5′-methylthioadenosine phosphorylase or 5′-methylthioadenosine nucleosidase. The invention also relates to the use of these compounds in the treatment of diseases or conditions in which it is desirable to in 5′-methylthioadenosine phosphorylase or 5′-methylthioadenosine nucleosidase... Albert Einstein College Of Medicine Inc

Oral administration of melanin for protection against radiation

Methods and compositions are provided for alleviating and/or preventing one or more side effects associated with exposure to radiation in a subject exposed to radiation or at risk for exposure to radiation comprising oral administration to the subject of an amount of an edible source of melanin effective to alleviate... Albert Einstein College Of Medicine Inc

Therapeutic nanoparticles and methods thereof

Described herein is a method of preparing a hybrid hydrogel paramagnetic nanoparticle. In certain embodiments, the hybrid hydrogel paramagnetic nanoparticle comprises a therapeutic agent. In certain embodiments, the nanoparticle contains alcohol. In certain embodiments, the nanoparticles incorporate fatty acids. Also described herein, is a method of preparing a hybrid hydrogel... Albert Einstein College Of Medicine Inc

Targeting dimerization of bax to modulate bax activity

Methods are provided for identifying an agent that directly modulates a Bcl-2- associated x-protein (BAX) by promoting or disrupting dimerization of the BAX. Agents that directly modulate BAX by affecting dimerization are also provided.... Albert Einstein College Of Medicine Inc

Use of tgf-beta antagonists of treat type-2 diabetes

Method and compositions for treating type-2 diabetes in a subject are provided comprising administering to the subject an amount of an inhibitor of a TGF-beta.... Albert Einstein College Of Medicine Inc

Compositions and methods for enhancing red blood cell storage time and survivability using nitric oxide releasing hybrid hydrogel nanoparticles

Described herein are hydrogel-based nanoparticles which release nitric oxide (NO) or other bioactive forms of NO including nitrosothiols, nitrofatty acids and dinitrogen trioxide into stored red blood cells (RBCs). Also provided herein is a method for using hydrogel-based nanoparticles to supplement stored RBCs with NO to enhance red blood cell... Albert Einstein College Of Medicine Inc

Therapy for filovirus infection

The present invention addresses a need for improved treatments for Filovirus infections.... Albert Einstein College Of Medicine Inc

Treatment of multiple sclerosis by inhibition of allograft inflammatory factor-1

Methods are disclosed for treating multiple sclerosis comprising administering an agent that reduces expression and/or activity of Allograft inflammatory factor-1 (Aif-1) in a subject and for screening for such agents.... Albert Einstein College Of Medicine Inc

Reversibly switchable photoacoustic imaging systems and methods

Reversibly switchable photoacoustic tomography (RS-PAT), a photoacoustic technique with enhanced sensitivity and resolution, is disclosed. RS-PAT utilizes a subtractive process for the formation of a photoacoustic image of a region containing a plurality of switchable photoacoustic probes. In various aspects, the photoacoustic detection in RS-PAT imaging occurs minimally twice: a... Albert Einstein College Of Medicine Inc

Pyridoxamine for the treatment of sickle cell disease, thalassemia and related blood diseases

The present invention relates to treatments and therapies for anemia conditions and diseases of the blood, and more particular is a therapy for the acute and chronic treatment of sickle cell diseases and thalassemia by administration of pyridoxamine, or a pharmaceutically acceptable salt thereof, optionally in combination with an additional... Albert Einstein College Of Medicine Inc

Syntac polypeptides and uses thereof

Methods and compositions for clonally inhibiting or clonally stimulating T-cells are provided.... Albert Einstein College Of Medicine Inc

Retinoic acid receptor antagonists as chaperone-mediated authophagy modulators and uses thereof

Compounds, compositions and methods are provided for selectively activating chaperone-mediated autophagy (CMA), protecting cells from oxidative stress, proteotoxicity and lipotoxicity, and/or antagonizing activity of retinoic acid receptor alpha (RARα) in subjects in need thereof.... Albert Einstein College Of Medicine Inc

Antibodies to human b7x for treatment of metastatic cancer

Methods are provided for treating metastatic cancer in patients having metastatic cancer or for preventing metastasis in cancer patients at risk for metastasis comprising administering to the patient an antibody to B7x, or an active antibody fragment that binds B7x, in an amount effective to treat or prevent metastasis.... Albert Einstein College Of Medicine Inc

Method of diagnosis and treatment of tumors using high intensity focused ultrasound

A method of diagnosis and treatment of tumors using High Intensity Focused Ultrasound is provided. The method of diagnosing the presence of a tumor in a patient comprises the steps of subjecting a tumor to high intensity focused ultrasound (HIFU) to cause the tumor cells to release cellular material and... Albert Einstein College Of Medicine Inc








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