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Beth Israel Deaconess Medical Center Inc
Beth Israel Deaconess Medical Center
Beth Israel Deaconess Medical Center Inc bidmc Inc
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Beth Israel Deaconess Medical Center Inc And Trustees Of Boston University

Beth Israel Deaconess Medical Center patents


Recent patent applications related to Beth Israel Deaconess Medical Center. Beth Israel Deaconess Medical Center is listed as an Agent/Assignee. Note: Beth Israel Deaconess Medical Center may have other listings under different names/spellings. We're not affiliated with Beth Israel Deaconess Medical Center, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "B" | Beth Israel Deaconess Medical Center-related inventors


Diabetes treatment

Methods and compositions for treating a patient who has recently developed diabetes are provided. The methods can include administering a tolerance-restoring agent to the patient and simultaneously administering intensive insulin therapy.... Beth Israel Deaconess Medical Center

Compositions and methods of treating cancer

The present invention provides compositions and methods for treating cancer.... Beth Israel Deaconess Medical Center

Compositions and methods of treating cancer

The present invention provides compositions and methods for treating cancer.... Beth Israel Deaconess Medical Center

Bacterial mediated thf alpha gene silencing

Methods are described for the delivery of one or more small interfering RNAs (siRNAs) to a eukaryotic cell using a bacterium. Methods are also described for using this bacterium to regulate gene expression in eukaryotic cells using RNA interference, and methods for treating an inflammatory disease or disorder. The bacterium... Beth Israel Deaconess Medical Center

Compositions and methods of treating renal cell cancer

The present invention provides compositions and methods for treating renal cell carcinoma... Beth Israel Deaconess Medical Center

Compositions and methods of treating acute myeloid leukemia

The present invention provides compositions and methods for treating acute myeloid leukemia.... Beth Israel Deaconess Medical Center

Compositions and methods of treating multiple myeloma

The present invention provides compositions and methods for treating multiple myeloma.... Beth Israel Deaconess Medical Center

Micro-rna inhibitors and their uses in disease

The invention relates to the treatment and prevention of cancer by administering agents that inhibit the activity of microRNAs that modulate tumor suppressor genes, which can include PTEN, p53, and INPP4B, among others. Inhibitors can include oligonucleotides that are at least partially complementary to these miRNAs. In some embodiments, these... Beth Israel Deaconess Medical Center

Magnetic resonance imaging that nulls signals from two or more tissues to better delineate an interested tissue

A system and method for acquiring magnetic resonance imaging (MRI) images with an MRI system is provided. The system and method directs the MRI system first to produce an inversion recovery radio frequency (RF) pulse, wait for a time period, produce a T2-preparation RF pulse, wait for another time period,... Beth Israel Deaconess Medical Center

Methods for detecting braf in cancer

The invention features compositions and methods for detecting and quantifying BRAFV600E in a sample of a subject. In particular embodiments, the invention provides a highly sensitive and precise quantitative method for diagnosis, post-operative surveillance, and monitoring evidence of disease over time in the adjuvant setting (i.e. treatment with BRAF-inhibitors).... Beth Israel Deaconess Medical Center

Method and a system for optimizing the configuration of multisite transcranial current stimulation and a computer-readable medium

A system and a method for optimizing the configuration of multisite transcranial current stimulation, including providing an electric field characteristic target map on the brain's cortex, the target map including multiple cortical targets, the multiple cortical targets are localized and/or continuously varying and spatially extended, providing a weight map on... Beth Israel Deaconess Medical Center

Dietary emulsion formulations and methods for using the same

Disclosed herein is a formulation that can take the form of an emulsion which contains total enteral or parenteral nutrition for a recipient subject. The formulation includes as the sole fat components: (i) medium chain triglycerides; and (ii) very long chain fatty acids selected from (a) very long chain omega-3... Beth Israel Deaconess Medical Center

Novel fusion-circular rnas and uses thereof

Novel fusion-circular RNAs (f-circRNAs) and complements thereof are provided. Diagnostic and treatment methods using f-circRNA inhibitors are provided. Non-human animals expressing exogenous f-circRNA and complements thereof are also provided.... Beth Israel Deaconess Medical Center

Biochemically stabilized hiv-1 env trimer vaccine

Stabilized trimers of a clade A strain and a clade C strain of HIV-1 are provided. Broadly neutralizing antisera against HIV-1, methods of making broadly neutralizing antisera against HIV-1, broadly neutralizing vaccines against HIV-1, as well as methods of treating subjects infected with HIV, preventing HIV infection, and inhibiting HIV-mediated... Beth Israel Deaconess Medical Center

Use of charge-balanced imaging agents for determining renal function

The present invention relates to a method for detecting renal disease and for assessing the efficacy of dialysis treatment using imaging agents having desirable in vivo properties.... Beth Israel Deaconess Medical Center

Antiviral vaccines with improved cellular immunogenicity

The invention provides compositions, methods, and kits for the treatment or prevention of viral infections. The polyvalent (e.g., 2-valent) vaccines described herein incorporate computationally-optimized viral polypeptides that can increase the diversity or breadth and depth of cellular immune response in vaccinated subjects.... Beth Israel Deaconess Medical Center

Methods of treating autoimmune and/or glomerulonephritis-associated diseases using shp2 inhibitors

Methods are disclosed herein for administering a oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2) inhibitor for treating autoimmune and/or glomerulonephritis-associated diseases, and in particular, Systemic Lupus Erythematosus (SLE).... Beth Israel Deaconess Medical Center

Methods and compositions for the generation and use of conformation-specific antibodies

The present invention features methods and compositions for the generation and use of conformation-specific antibodies or fragments thereof.... Beth Israel Deaconess Medical Center

System and enhancing functional medical images

Systems and methods for generating a medical image of a subject that includes functional information. First, two medical images are acquired. One is weighted based on functional information reflecting physiological functions of the subject and the other weighted based on anatomic information of the subject. A difference image between the... Beth Israel Deaconess Medical Center

Enhanced atra-related compounds for the treatment of proliferative diseases, autoimmune diseases, and addiction conditions

The invention features all-trans retinoic acid (ATRA)-related compounds capable of associating with Pin1 and methods of treating a proliferative disorder characterized by elevated Pin1 marker levels, Pin1 degradation, and/or reduced Pin1 Ser71 phosphorylation in a subject by administering an ATRA-related compound. The invention also features methods of treating proliferative disorders,... Beth Israel Deaconess Medical Center

Methods for inducing an immune response against human immunodeficiency virus infection in subjects undergoing antiretroviral treatment

Methods for inducing an immune response against Human Immunodeficiency Virus (HIV) in HIV-infected subjects undergoing antiretroviral therapy (ART) are described. The methods include administering an adenovirus vector primer vaccine and a modified vaccinia virus (MVA) vector booster vaccine encoding mosaic HIV antigens.... Beth Israel Deaconess Medical Center

Therapeutic use of mitochondria and combined mitochondrial agent

The disclosure relates to compositions comprising isolated mitochondria or combined mitochondrial agents, and methods of treating disorders using such compositions.... Beth Israel Deaconess Medical Center

Immunoassays for differential detection of clostridium difficile

Ultrasensitive and quantitative assays for detecting toxins of Clostridium difficile, which may involve digital ELISA, are provided. Also provided herein are differential detection assays that allow for distinguishing toxin B of highly virulent Clostridium difficile strains from toxin B of less virulent strains.... Beth Israel Deaconess Medical Center

Cancer therapy targeting intercellular adhesion molecule 4 (icam4)

Methods for treating cancer, e.g., in conjunction with anti-cancer therapy, like immunotherapy, and for identifying candidate therapeutic agents, by targeting ICAM4. While MDSCs in mice have been extensively characterized, their human counterparts are not well defined, and cell markers present in mice are not always usable in humans. MDSCs have... Beth Israel Deaconess Medical Center

Reduced field-of-view perfusion imaging with high spatiotemporal resolution

Some aspects of the present disclosure relate a method for magnetic resonance imaging, which can include acquiring, by applying an imaging pulse sequence, magnetic resonance data associated with a region of interest of a subject. The imaging pulse sequence can include a plurality of RF pulses configured to generate a... Beth Israel Deaconess Medical Center

Method and system to access inapparent conduction abnormalities to identify risk of ventricular tachycardia

A method and system for determining a patient's risk of ventricular tachycardia are disclosed. The method includes receiving ECG signals from a patient and filtering the collected ECG signals to generate filtered ECG signals. The method further includes identifying a heart vector from the filtered ECG signals, and measuring a... Beth Israel Deaconess Medical Center

Dietary emulsion formulations and methods for using the same

Disclosed herein is a formulation that can take the form of an emulsion which contains total enteral or parenteral nutrition for a recipient subject. The formulation includes as the sole fat components: (i) medium chain triglycerides; and (ii) very long chain fatty acids selected from (a) very long chain omega-3... Beth Israel Deaconess Medical Center

Compounds and compounds for use in methods for treating diseases or conditions mediated by protein disulfide isomerase

The invention provides compounds of formula (I) that inhibit PDI, for use in methods to treat or prevent a disease or condition in a subject that would benefit by inhibition of PDI. Formula (I).... Beth Israel Deaconess Medical Center

Methods and compositions for the inhibition of pin1

The invention features compositions and methods for inhibiting the Pin1 protein, and the treatment of disorders characterized by elevated Pin1 levels.... Beth Israel Deaconess Medical Center

Sn-2-monoacylglycerols and lipid malabsorption

The present invention relates generally to the field of lipids and in particular aims at improving lipid absorption, for example under conditions of lipid maldigestion or malabsorption. One embodiment of the present invention relates to a composition comprising a sn-2 monoacylglycerol derivative, wherein the sn-1 and sn-3 positions are blocked... Beth Israel Deaconess Medical Center

Charge-balanced imaging agents

The present invention relates to compositions for and methods of optically imaging tissues or cells using imaging agents having desirable in vivo properties that result in improved signal-to-background ratio.... Beth Israel Deaconess Medical Center

Devices for wound healing

The present invention provides devices and methods for improving wound healing, in particular, in diabetic subjects.... Beth Israel Deaconess Medical Center

Methods of diagnosing and treating complications of pregnancy

Disclosed herein are methods for treating a pregnancy related hypertensive disorder, such as pre-eclampsia and eclampsia, using combinations of compounds that alter soluble endoglin, endothelial nitric oxide synthase, PGI2, TGF-β1, TGF-β3, activin A, BMP2, BMP7, and sFlt-1 expression levels or biological activity. Also disclosed are methods of diagnosing a pregnancy... Beth Israel Deaconess Medical Center

Poly-n-acetyl glucosamine (pnag/dpnag)-binding peptides and methods of use thereof

The present invention relates to peptides, particularly human monoclonal antibodies, that bind specifically to poly-N-acetyl glucosamine (PNAG), such as Staphylococcal PNAG, in acetylated, partially acetylated and/or fully deacetylated form. The invention further provides methods for using these peptides in the diagnosis, prophylaxis and therapy of infections by bacteria that express... Beth Israel Deaconess Medical Center

Atra for modulating pin1 activity and stability

The present disclosure describes how all-retinoic acid (ATRA) binds and inhibits Pin1 activity and induces degradation of the activated Pin1 monomer selectively in cancer cells. Identification of the binding mechanism of ATRA with Pin1 confirm ATRA binding specificity to Pin1 residues in the PPIase active site, thus demonstrating that drug-induced... Beth Israel Deaconess Medical Center

07/20/17 / #20170204466

Biomarkers for pin1-associated disorders

Biomarkers and driver mutations for diagnosis and prognosis of Pin 1-associated diseases are disclosed. In one embodiment, the methods for diagnosis of Pin 1-associated diseases may include detecting the level of Pin1 to stage abnormal cell growth, such as breast or prostate cancer. In another embodiment, the methods include evaluating... Beth Israel Deaconess Medical Center

07/06/17 / #20170189483

Diagnostic and therapeutic uses of gelsolin in renal failure

The invention is directed, in part, to the use of gelsolin to diagnose, monitor, and treat subjects with renal failure (e.g., chronic renal failure subjects on dialysis).... Beth Israel Deaconess Medical Center

07/06/17 / #20170190762

Alpha1 -antitrypsin compositions and methods of treating autoimmune diseases

The specification provides compositions comprising chimeric proteins comprising AAT conjugated to an Fc region of an immunoglobulin. Methods for treating autoimmune disease, e.g., diabetes, e.g., Type 1 and Type 2 diabetes, are also provided.... Beth Israel Deaconess Medical Center

06/29/17 / #20170182119

Compositions and methods for modulating ncoa4-mediated autophagic targeting of ferritin

Described herein are methods of modulating autophagic targeting of ferritin in a cell, wherein the method comprises modulating the level and/or activity of nuclear receptor coactivator 4 (NCOA4) in the cell. Also provided are related methods of treatment.... Beth Israel Deaconess Medical Center

06/22/17 / #20170173218

Activation of antimicrobial agents

Post-operative infection in joint prostheses is a problem due to adverse consequences such as surgical debridement or implant removal. Embodiments create a coating that can be powered to release microbicidal agents to both ensure the prevention of infections, and avoid the development of antibiotic resistance. Silver ions have been well... Beth Israel Deaconess Medical Center

05/04/17 / #20170120237

Products and methods to isolate mitochondria

Filtration apparatuses, kits, and methods for rapid isolation of intact, viable mitochondria from tissues are described with mitochondria isolated by differential filtration through nylon mesh filters. Mitochondria can be isolated in less than 30 minutes using the filtration apparatuses, kits, and methods described.... Beth Israel Deaconess Medical Center

05/04/17 / #20170121772

Biomarkers and treatments for heart failure

The invention features methods to predict the response to a cardiac therapy in a patient suffering from a cardiac disease, e.g., heart failure. The invention features measurement expression of biomarkers that help in this prediction. The invention also features methods for treatment of cardiac diseases. These methods include cardiac resynchronization... Beth Israel Deaconess Medical Center

04/27/17 / #20170112792

Enhanced atra-related compounds derived from structure-activity relationships and modeling for inhibiting pin1

The invention features all-trans retinoic acid (ATRA)-related compounds capable of associating with Pin1 and methods of identifying the same. The invention also provides methods of treating a condition selected from the group consisting of a proliferative disorder, an autoimmune disease, and an addiction condition characterized by elevated Pin1 marker levels,... Beth Israel Deaconess Medical Center

04/06/17 / #20170097363

Buccal cell diagnosis of arrhythmogenic cardiomyopathy (acm)

Described herein are, inter alia, methods for diagnosing and treating arrhythmogenic cardiomyopathy (ACM) by detecting cardiac intercalated disk proteins, e.g., desmosomal proteins, mechanical and gap junction proteins, in buccal cells. Exemplary desmosomal and gap junction proteins that can be evaluated in the methods described herein include plakoglobin, plakophilin 1, desmoplakin,... Beth Israel Deaconess Medical Center

03/16/17 / #20170072018

Methods of diagnosing and treating complications of pregnancy

Disclosed herein are methods for diagnosing a pregnancy related hypertensive disorder or a predisposition to a pregnancy related hypertensive disorder by measuring the level or biological activity of soluble endoglin. Also disclosed herein are methods for treating a pregnancy related hypertensive disorder, such as pre-eclampsia and eclampsia, using compounds that... Beth Israel Deaconess Medical Center

03/16/17 / #20170073760

Methods for treating cancer resistant to erbb therapeutics

Provided herein are methods for treating cancer that is resistant to treatment with an anti-ErbB therapeutic agent and which is associated with an activating MET gene mutation or a MET gene amplification. The methods involve administering to a subject a combination of an anti-ErbB therapeutic and an anti-MET therapeutic. Also... Beth Israel Deaconess Medical Center

03/09/17 / #20170065688

Compositions containing alpha-1-antitrypsin and methods for use

Methods and compositions for treating patients (e.g., patients who are insulin resistant, patients who have diabetes, or are at risk for developing diabetes) are disclosed herein. The methods can include administration of an al antitrypsin (AAT) polypeptide or an agent, such as a nucleic acid molecule or organic compound, that... Beth Israel Deaconess Medical Center

02/23/17 / #20170049136

Methods for determination of bioactivity, removal, or inactivation cereal amylase trypsin inhibitors in cereals, flours and complex foods

The present invention features methods of extracting amylase trypsin inhibitors (ATIs) from processed and unprocessed foodstuff, determining bioactivity of ATIs, qualifying the amount of ATIs in a foodstuff, and reducing the content of ATIs in a foodstuff.... Beth Israel Deaconess Medical Center

02/09/17 / #20170035319

Rapid 3d dynamic arterial spin labeling with a sparse model-based image reconstruction

Methods, systems, and computer-readable media for rapid 3D dynamic arterial spin labeling with a sparse model-based image reconstruction are disclosed. In one embodiment, a method includes acquiring magnetic resonance data associated with an area of interest of a subject. The magnetic resonance data includes associated with arterial spin labeling (ASL)... Beth Israel Deaconess Medical Center

02/02/17 / #20170027994

Differentiation of stem cells into thyroid tissue

Embodiments herein relate in vitro methods of stem cell differentiation into thyroid hormone producing cells and tissues, and methods of use of these cells.... Beth Israel Deaconess Medical Center

01/12/17 / #20170007151

Electrical impedance myography

Electrical impedance myography (EIM) can be used for assessment and diagnosis of muscular disorders. EIM includes applying an electrical signal to a region of tissue and measuring a resulting signal. A characteristic of the region of tissue is determined based on the measurement. Performing EIM at different frequencies and modeling... Beth Israel Deaconess Medical Center








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