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Brandeis University patents

Recent patent applications related to Brandeis University. Brandeis University is listed as an Agent/Assignee. Note: Brandeis University may have other listings under different names/spellings. We're not affiliated with Brandeis University, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "B" | Brandeis University-related inventors

Preparation and use of novel protein kinase inhibitors

The invention provides novel compounds and methods of using such compounds to treat or prevent cancer.. . ... Brandeis University

Synthetic peptides and enzymatic formation of intracellular hydrogels

The invention relates to a peptide that includes a plurality of amino acid residues and an enzymatically cleavable moiety including taurine or hypotaurine, the enzymatically cleavable-moiety being linked to the peptide via covalent bond, wherein the peptide is capable of self-assembly to form nanofibrils in the presence of an enzyme that hydrolyzes the enzymatically cleavable-moiety. Compositions containing the enzymatically responsive peptide, and the use thereof for forming a nanofibril network internally of cells, for treating a cancerous condition, and imaging cells are also disclosed.. ... Brandeis University

Reagents and methods of pcr

Modified double-stranded oligonucleotides that have terminal regions on each of their strands, that have a hybrid length of 6-50 nucleotides long, that have a melting temperature tm of at least 32° c., and that include 2-4 modifying groups, each covalently attached to a different terminal region, preferably to a terminal nucleotide, said modifying groups being polycyclic substituents that do not have bulky portions that are non-planar, said modified oligonucleotide being capable of binding to the 5′ exonuclease domains of dna polymerases and, when included in a pcr or other primer-dependent dna amplification reaction at a concentration, generally not more than 2000 nm, that is effective for at least one of the functions of suppressing mispriming, increasing polymerase selectivity against 3′ terminal mismatches. Increasing polymerase selectivity against at-rich 3′ ends, reducing scatter among replicates, suppressing polymerase 5′ exonuclease activity, and inhibiting polymerase activity; as well as amplification reaction mixtures containing such modified double-stranded oligonucleotides, and amplification reactions, amplification assays and kits that include such modified double-stranded oligonucleotides.. ... Brandeis University

Nras related cancer therapy

The present invention encompasses the recognition that identification of alternative means to block ras oncogenic signaling may be required for developing novel cancer therapies. Among other things, the present invention encompasses the recognition that targeting ras palmitoylation can achieve effective therapy for ras-related cancers. ... Brandeis University

Biophysical platform for drug development based on energy landscape

In one aspect, the present invention provides a method of selecting or identifying an agent that inhibits a target protein having an active site. In another aspect, the invention provides a method of selecting an agent that inhibits a target protein having an active site for further optimization. ... Brandeis University

Drip-free glass bottles having a circumferential channel and methods of making and using such bottles

Described herein is a glass bottle configured to improve the mechanics of liquid flow and prevent drip initiation. Additionally, the glass bottle eliminates dripping during pouring to enable drip-free pouring. ... Brandeis University

System and method for differential analysis

The present disclosure includes systems and methods for performing a plurality of base statistical analysis on a dataset to yield multiple, different base statistics with respect to a first predetermined number of features. The dataset and the base statistics can be used to find a transformation that determines significant features while controlling a false discovery rate (fdr) to be below a target fdr threshold (Ψ), wherein a second predetermined number of features are assumed to be independent from each other. ... Brandeis University

Microfluidic devices for investigating crystallization

Microfluidic devices and methods for investigating crystallization and/or for controlling a reaction or a phase transition are disclosed. In one embodiment, the microfluidic device includes a reservoir layer; a membrane disposed on the reservoir layer; a wetting control layer disposed on the membrane; and a storage layer disposed on the wetting control layer, wherein the wetting control layer and the storage layer define a microfluidic channel comprising an upstream portion, a downstream portion, a first fluid path in communication with the upstream and the downstream portions, and a storage well positioned within the first fluid path, wherein the wetting control layer includes a fluid passageway in communication with the storage well and the membrane, and wherein the wetting control layer wets a first fluid introduced into the microfluidic channel, the first fluid comprising a hydrophilic, lipophilic, fluorophilic or gas phase as the continuous phase in the microfluidic channel.. ... Brandeis University

Cooling systems and methods for cryo super-resolution fluorescence light microscopy and other applications

New systems and methods are described for maintaining a desired steady state temperature differential between two objects that may otherwise undergo heat transfer to restore thermal steady state. In one application, a cooling microscope assembly and its use with conventional optical microscopes are described for achieving super-resolution imaging. ... Brandeis University

Inhibitors of deubiquitinating proteases

Disclosed are small molecule inhibitors of deubiquitinating enzymes (dubs), and methods of using them. Certain compounds are selective for particular ubiquitin-specific proteases (usps).. ... Brandeis University

Enzymatically responsive magnetic particles and their use

The invention relates to an enzymatically responsive product that includes an amino acid residue conjugated to a magnetic particle, wherein the amino acid residue is phosphorylated or sulfated or comprises an ester-moiety linked via peptide bond. Compositions containing the enzymatically responsive product, and the use thereof for separating distinct types of mammalian cells (e.g., cancer cells from normal cells), for treating a cancerous condition, and imaging cancer cells are also disclosed.. ... Brandeis University

Synthetic peptides, enzymatic formation of pericellular hydrogels/nanofibrils, and methods of use

Disclosed are peptides that contain up to about 35 amino acids, including a plurality of aromatic amino acid residues and either (i) an amino acid residue that is phosphorylated or sulfated, or (ii) an amino acid comprising an ester-moiety linked via peptide bond, or both (i) and (ii), wherein the peptide is capable of self-assembly to form nanofibrils in the presence of an enzyme that hydrolyzes the phosphate group, the sulfate group, or the ester-moiety. These peptides are enzymatically responsive hydrogelators, and they can be used to form pericellular hydrogels/nanofibrils upon exposure to target cells that secrete or express a surface bound ectoenzyme having hydrolase activity suitable to induce peptide gelation. ... Brandeis University

Manipulation of fluids and reactions in microfluidic systems

Microfluidic structures and methods for manipulating fluids and reactions are provided. Such structures and methods may involve positioning fluid samples, e.g., in the form of droplets, in a carrier fluid (e.g., an oil, which may be immiscible with the fluid sample) in predetermined regions in a microfluidic network. ... Brandeis University

Methods of identifying insect-trpa1 modulators

The invention provides a screening method for identifying an insect-specific trpa1 modulator by comparing modulation of an insect trpa1 and a mammalian trpa1. The invention further provides method of insect control by applying to an insect a insect-specific trpa1 modulator identified by the screening method.. ... Brandeis University

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009


This listing is an abstract for educational and research purposes is only meant as a recent sample of applications filed, not a comprehensive history. is not affiliated or associated with Brandeis University in any way and there may be associated servicemarks. This data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Brandeis University with additional patents listed. Browse our Agent directory for other possible listings. Page by