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Brandeis University patents (2015 archive)


Recent patent applications related to Brandeis University. Brandeis University is listed as an Agent/Assignee. Note: Brandeis University may have other listings under different names/spellings. We're not affiliated with Brandeis University, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "B" | Brandeis University-related inventors


11/12/15 / #20150322503

Reagents and methods of pcr

Modified double-stranded oligonucleotides that have terminal regions on each of their strands, that have a hybrid length of 6-50 nucleotides long, that have a melting temperature tm of at least 32° c., and that include 2-4 modifying groups, each covalently attached to a different terminal region, preferably to a terminal nucleotide, said modifying groups being polycyclic substituents that do not have bulky portions that are non-planar, said modified oligonucleotide being capable of binding to the 5′ exonuclease domains of dna polymerases and, when included in a pcr or other primer-dependent dna amplification reaction at a concentration, generally not more than 2000 nm, that is effective for at least one of the functions of suppressing mispriming, increasing polymerase selectivity against 3′ terminal mismatches. Increasing polymerase selectivity against at-rich 3′ ends, reducing scatter among replicates, suppressing polymerase 5′ exonuclease activity, and inhibiting polymerase activity; as well as amplification reaction mixtures containing such modified double-stranded oligonucleotides, and amplification reactions, amplification assays and kits that include such modified double-stranded oligonucleotides.. ... Brandeis University

10/29/15 / #20150306232

Hydrogelators comprising d-amino acids

Described herein are compounds comprising an oligopeptide and a non-steroidal antiinflammatory agent. The compounds self-assemble into supramolecular hydrogels and can be used as topical treatments for inflammatory conditions, such as osteoarthritis. ... Brandeis University

09/17/15 / #20150259391

Treatment of amyotrophic lateral sclerosis

Nonsense-mediated mrna decay (nmd) polypeptides, nucleic acids encoding nmd polypeptides, and methods of using such polypeptides and nucleic acids in the treatment of als and in screening for agents for the treatment of als are described.. . ... Brandeis University

09/03/15 / #20150248002

Cooling systems and methods for cryo super-resolution flourescence light microscopy and other applications

New systems and methods are described for maintaining a desired steady state temperature differential between two objects that may otherwise undergo heat transfer to restore thermal steady state. In one application, a cooling microscope assembly and its use with conventional optical microscopes are described for achieving super-resolution imaging. ... Brandeis University

08/06/15 / #20150218625

Combination of dsdna binding dye and probes for characterization of ssdna sequences

This invention includes methods for analyzing single-stranded nucleic acid sequences, either rna sequences or dna sequences (ssdna) utilizing dyes that fluoresce when associated with double strands, so-called dna binding dyes or dsdna-dyes. Methods according to this invention utilize a dsdna-dye in combination with one or more hybridization probes that hybridize to a target nucleic acid sequence and that are labeled with a non-fluorescent quencher moiety, for example, a black hole quencher.. ... Brandeis University

05/28/15 / #20150148252

Multiplex target detection assay

Provided herein are reagents and kits for detection of multiple target sequences in a single-tube, single-color assay, and methods of use thereof. In particular, multiplex assays are provided for the detection of mycobacterium tuberculosis complex target sequences (e.g., katg, rpob, inha promotor, pnca, etc.).. ... Brandeis University

04/30/15 / #20150118761

Manipulation of fluids and reactions in microfluidic systems

Microfluidic structures and methods for manipulating fluids and reactions are provided. Such structures and methods may involve positioning fluid samples, e.g., in the form of droplets, in a carrier fluid (e.g., an oil, which may be immiscible with the fluid sample) in predetermined regions in a microfluidic network. ... Brandeis University

03/19/15 / #20150079226

Vegetable oil composition containing palm mid-fraction fat and method of reducing plasma cholesterol

A method and composition for reducing the cholesterolemic effect in mammals of ingesting a blended nutritional fat composition containing a palm mid-fraction (pmf) hardstock fat combined with an unsaturated vegetable oil. The composition is solid or semi-solid at 20° c. ... Brandeis University

01/22/15 / #20150024105

Par-baked and milled coffee beans for use in foods, beverages and dietary supplements

The present invention concerns compositions and methods relating to the addition and use of par-baked and milled coffee beans in food products, beverages, and dietary supplements. Par-baked and milled coffee beans are a novel alternative to more costly chlorogenic acid extracts, and are edible and palatable as a food ingredient. ... Brandeis University








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