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California Institute Of Technology
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California Institute Of Technology patents


Recent patent applications related to California Institute Of Technology. California Institute Of Technology is listed as an Agent/Assignee. Note: California Institute Of Technology may have other listings under different names/spellings. We're not affiliated with California Institute Of Technology, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "C" | California Institute Of Technology-related inventors


 new patent  Fractional initiator hybridization chain reaction

The present disclosure relates to methods and compositions involving HCR reactions that involve initiators that are split into two or more parts. Effective HCR is dependent upon two or more of these split initiators being brought into proximity (e.g., via binding events mediated by a target) such that a full... California Institute Of Technology

Integrated hybrid nems mass spectrometry

A hybrid mass spectrometer comprising: an ion source for generating ions from a sample, a first mass spectral system comprising a nanoelectromechanical mass spectral (NEMS-MS) system, a second mass spectral system including at least one mass analyzer adapted to separate the charged particles according to their mass-to-charge ratios, and an... California Institute Of Technology

High-q optical resonator with monolithically integrated waveguide

A ring optical resonator is formed on a substrate. An outer circumferential surface of the resonator substantially confines one or more circumferential resonant optical modes. The resonator is positioned above a void formed in the substrate and is supported above the void by a portion of a material layer on... California Institute Of Technology

Nucleic acid reactions and related methods and compositions

The present invention relates to methods of nucleic acid analyte detection by PCR. In particular, methods and kits for the detection of a plurality of nucleic acid analytes and the generation of kinetic signatures are provided. Further provided are methods and kits of nested PCR and PCR using limiting primers.... California Institute Of Technology

Multiplex q-pcr arrays

This invention provides methods and systems for measuring the concentration of multiple nucleic acid sequences in a sample. The nucleic acid sequences in the sample are simultaneously amplified, for example, using polymerase chain reaction (PCR) in the presence of an array of nucleic acid probes. The amount of amplicon corresponding... California Institute Of Technology

Pupil ptychography methods and systems

Certain embodiments pertain to pupil ptychography methods and systems.... California Institute Of Technology

Systems and methods for tracking moving objects

Systems and methods for tracking moving objects in accordance with embodiments of the invention are disclosed. In one embodiment of the invention, an object tracking system comprises a processor, a communications interface, and a memory configured to store an object tracking application. The object tracking application configures the processor to... California Institute Of Technology

Brain-machine interface based on photonic neural probe arrays

Method and apparatus for illuminating and imaging tissue is provided. In one version, the method includes illuminating a volume of a tissue with photons from a three-dimensional array of optical emitters inserted into the tissue. In another version, the method includes detecting photons from a volume of a tissue using... California Institute Of Technology

Implantable oxygen generator and transporter

An implantable medical device is described. The implantable medical device includes a small molecule generator, a small molecule diffusor, and a cannula that connects the two. The small molecule generator includes an electrolyte reservoir and a set of electrodes. A first portion of the electrolyte reservoir is impermeable to a... California Institute Of Technology

Methods and assays of bacterial spores

Described herein are methods and apparatus for assays of bacterial spores. In particular, methods and apparatus for lateral flow immunoassay for bacterial spore detection and quantification, live/dead assay for bacterial spores, lifetime-gated measurements of bacterial spores and imaging bacterial spores using an active pixel sensor, and unattended monitoring of bacterial... California Institute Of Technology

Laser wireless power transfer system with active and passive safety measures

A wireless laser power transfer system includes, in part, a transmitter and a receiver that form a wireless link. The transmitter, includes, in part, a first communication system, at least a first source of laser beam, and a controller adapted to vary power and direction of the laser beam and... California Institute Of Technology

In situ chemical sensing electrode reconditioning

A cycle of positive and negative voltage pulses applied to an electrode sensor removes passivation of an electrode surface. The conditioned sensors have improved sensitivity to concentrations for analytes of interest. The electrode surfaces can also be passivated on purpose to reduce sensitivity. The voltages applied are varied according to... California Institute Of Technology

Tandem transfer hydrogenation and oligomerization for hydrocarbon production

A method for coupling an alkane with an alkene using a hydrogen transfer catalyst and an alkene dimerization catalyst to form one or more higher molecular weight hydrocarbons.... California Institute Of Technology

Label-free detection of nanoparticles and biological molecules using microtoroid optical resonatiors

Systems and methods are provided for detecting one or more particles such as individual unlabeled molecules or single nanoparticles. In examples described herein, optical energy is introduced into a microtoroid or other microcavity to generate an evanescent field. The microcavity has a functionalized outer surface that has been functionalized with... California Institute Of Technology

Modular optical phased array

A phased array includes, in part, M×N photonic chips each of which includes, in part, an array of transmitters and an array of receivers. At least one of M and/or N is an integer greater than one. The transmitter arrays in each pair of adjacent photonics chips are spaced apart... California Institute Of Technology

Compositions and methods for leukocyte differential counting

The present invention provide compositions and methods for classifying leukocytes in a leukocyte population using fluorescence detection. The methods include contacting a leukocyte population in a sample having one or more leukocyte types with a diagnostic composition, exciting the leukocyte population with a light source; and measuring emitted light from... California Institute Of Technology

Backscatter imaging systems and methods with helical motion

Backscatter imaging systems and methods that involve moving an emitter and a broad spectrum detector in helical motion along a medium being imaged while the emitter emits substantially monochromatic X-rays and/or gamma rays, and the broad spectrum detector acquires intensity measurement of photons backscattered from the medium. The intensity measurements... California Institute Of Technology

Systems and methods for detecting abnormalities in electrical and electrochemical energy units

A method for abnormality detection in an energy unit includes passively detecting an abnormality in an energy unit by detecting electromagnetic radiation generated by the abnormality, the energy unit comprising at least one of an electrical energy unit and an electrochemical energy unit. A method for detecting an abnormality in... California Institute Of Technology

Spatial power combining mechanism (spcm) for the generation and amplification of electromagnetic radiation

A Spatial Power Combining Amplifier (SPCA) exhibiting a new concept for the amplification of coherent (e.g., microwave) radiation. A general description of the SPCA a power analysis at various SPCA stages is provided. A successfully tested S-band SPCA example was able to deliver 120 W of power with a gain... California Institute Of Technology

Systems and methods for generating spatial sound information relevant to real-world environments

Spatial exploration systems and methods of spatial exploration utilizing spatial sound in accordance with various embodiments of the invention are disclosed. In one embodiment, a spatial exploration system acquires sensor data and constructs a 3D spatial model of a surrounding real world environment. The system can instantiate a 3D object... California Institute Of Technology

Three-dimensional ion transport networks and current collectors for electrochemical cells

Provided herein are three-dimensional ion transport networks and current collectors for electrodes of electrochemical cells. Exemplary electrodes include interconnected layers and channels including an electrolyte to facilitate ion transport. Exemplary electrodes also include three dimensional current collectors, such as current collectors having electronically conducting rods, electronically conducting layers or a... California Institute Of Technology

Targeted nanoparticles

Described herein are carrier nanoparticles comprising a polymer containing a polyol coupled to a polymer containing a nitroboronic boronic acid and a linkage cleavable under reducing conditions, configured to present the polymer containing the nitroboronic acid to an environment external to the nanoparticle. Targeted versions of the described nanoparticles are... California Institute Of Technology

Thermal bioswitches and related genetic circuits, vectors, cells, compositions, methods and systems

Temperature sensitive transcriptional bioswitches and related genetic circuits and in particular bandpass and/or multiplex genetic circuits, vectors, cells, compositions methods and systems are described.... California Institute Of Technology

High pressure high flow digital valve with locking poppets and backflow prevention

A valve that allows control of each of one or more flow paths using one actuator is presented. Rotary motion of a motor is transformed into linear motion using a roller screw mechanism. The travel of the roller screw nut is predefined between front and back hard stops that prevent... California Institute Of Technology

Devices and methods for preparing biological samples

Devices and methods for biological sample preparation are provided herein. Components of such devices include a plurality of plungers that can be actuated for metering and/or mixing one or more agents. Methods of manufacturing such devices using 3D printing are also provided.... California Institute Of Technology

Array level fourier ptychographic imaging

In one aspect an imaging system includes: an illumination system including an array of light sources; an optical system including one or more lens arrays, each of the lens arrays including an array of lenses, each of the lenses in each of the one or more lens arrays in alignment... California Institute Of Technology

Stabilized non-reciprocal fiber-ring brillouin laser source

A stabilized laser source includes a fiber-ring Brillouin laser that incorporates a circulator for non-reciprocal operation and for launching of a pump optical signal. Most of the pump optical signal is launched in a forward direction and drives Brillouin laser oscillation in the backward direction, a portion of which exits... California Institute Of Technology

Methods for proteomic profiling using non-natural amino acids

The invention provides methods, reagents and systems for incorporating non-natural amino acids into proteins, preferably in vivo, using the endogenous protein synthesis machinery of an organism. The incorporated non-natural amino acids contain reactive groups for further chemical reagents, which may serve as a “handle” to enrich the proteins or fragments... California Institute Of Technology

Methods and system for interfering with viability of bacteria and related compounds and compositions

Provided herein are methods and systems for interfering with viability of bacteria and related compounds and compositions.... California Institute Of Technology

Hall effect thruster electrical configuration

A Hall thruster is configured to reduce or eliminate pole erosion by electrically tying the cathode to the thruster chassis body. The electrical connection controls the ion energy hence reducing erosion at the pole. In a different configuration, the cathode is biased by a power supply, allowing further control of... California Institute Of Technology

Structured light generator and object recognition apparatus including the same

A structured light generator includes a light source configured to emit light, and a first meta optical device including a first metasurface including nanostructures having sub-wavelength dimensions that are less than a wavelength of the light emitted from the light source, the first metasurface being configured to form a distribution... California Institute Of Technology

System and locating and performing fine grained classification from multi-view image data

Some embodiments of the invention provide a method for identifying geographic locations and for performing a fine-grained classification of elements detected in images captured from multiple different viewpoints or perspectives. In several embodiments, the method identifies the geographic locations by probabilistically combining predictions from the different viewpoints by warping their... California Institute Of Technology

Image sensor including nanostructure color filter

An image sensor includes a first light sensor layer including light sensing cells configured to sense first light of an incident light and generate electrical signals based on the sensed first light, and a color filter array layer disposed on the first light sensor layer, and including color filters respectively... California Institute Of Technology

Low-profile and high-gain modulated metasurface antennas from gigahertz to terahertz range frequencies

A modulated MTS antenna including a metasurface fabricated from metallized cylinders on a ground plane. The antenna structure can be designed to operate in the Gigahertz or Terahertz frequency band and to have a well defined directivity. The MTS antenna may be micromachined out of a silicon wafer using deep... California Institute Of Technology

Reduction of unmodulated ambient blockers in reflected data links through manipulation or replication of the transmitting signal source

Communication between a wireless base-station and a microwave reflector link are enhanced by feeding back a portion of the transmitter signal, adjusted for phase and amplitude, to cancel ambient reflection blocker signals being received at the base-station. The microwave reflector link does not utilize a transmitter gain stage, but communicates... California Institute Of Technology

09/28/17 / #20170273551

Fourier ptychographic retinal imaging methods and systems

Certain embodiments pertain to Fourier ptychographic retinal imaging methods and systems that focus on a retina of an eye to acquire a sequence of raw retinal images, construct a full-resolution, complex retinal image from the sequence of raw retinal image and correct the aberration in the full-resolution, complex retinal image... California Institute Of Technology

09/28/17 / #20170275399

Anion-coordinating polymer electrolytes and related compositions, methods and systems

Anion-coordinating polymers comprising one or more anion-coordinating unit of Formula (I), optionally in combination with one or more cation-coordinating unit of Formula (II) and/or a linking unit of Formula (III) and related electrolytes, batteries, methods and system.... California Institute Of Technology

09/28/17 / #20170275597

Phenazine degrading agents and related compositions, methods and systems for interfering with viability of bacteria

Provided herein are phenazine degrading agents, methods and systems for interfering with viability of bacteria and related antimicrobial and compositions.... California Institute Of Technology

09/21/17 / #20170266215

Redox-active compounds and related compounds, compositions, methods and systems

Compounds able to affect production and/or activity of a redox active compound, which include candidate therapeutic compounds and candidate compounds for enhancing power output of a microbial fuel cell, and related compositions, methods and systems.... California Institute Of Technology

09/21/17 / #20170270282

High-resolution mass spectrometer and methods for determining the isotopic anatomy of organic and volatile molecules

A mass spectrometer including an entrance slit, an energy filter, a momentum filter and a detector array, the entrance slit, energy filter and momentum filter being configured to provide molecular analyte ions to the detector array at a mass resolution of about 20,000 or greater. A method for determining the... California Institute Of Technology

09/14/17 / #20170258343

Intrinsic frequency hemodynamic waveform analysis

Hardware and software methodology are described for cardiac health measurement. Hemodynamic waveforms variously acquired for a subject are analyzed to calculate or approximate intrinsic frequencies in two domains in two domains across the Dicrotic Notch. The intrinsic frequencies provide metrics/ measures that correlate to the cardiac health of the subject.... California Institute Of Technology

09/14/17 / #20170259428

Wearable electromyography sensor array using conductive cloth electrodes for human-robot interactions

A sleeve worn on an arm allows detection of gestures by an array of sensors. Electromyography, inertial, and magnetic field sensors provide data that is processed to categorize gestures and translate the gestures into commands for robotic systems. Machine learning allows training of gestures to increase accuracy of detection for... California Institute Of Technology

09/14/17 / #20170260172

Compositions and methods for acylating lactams

This disclosure provides methods for intermolecular enantioselective C-acylation of lactams with quaternary stereogenic centers by applying a chiral Ni catalyst. The methods comprise treating a lactam with a chiral Ni catalyst, an aryl nitrile, and an aryl halide.... California Institute Of Technology

09/14/17 / #20170263363

Method and particle actuation in a space

A device is dynamically programmable to generate at least a first magnetic field during a first time interval, and at least a second magnetic field during a second time interval thereby causing the particles exposed to the change in the magnetic field to aggregate to a target region. The device... California Institute Of Technology

09/14/17 / #20170263796

Encapsulated solar cells that incorporate structures that totally internally reflect light away from front contacts and related manufacturing methods

Solar cells in accordance with a number of embodiments of the invention are encapsulated by a material that can render the front contacts of the solar cells effectively invisible at certain angles of incidence. Front contacts of a solar cell provide a way for current to escape from the solar... California Institute Of Technology

09/07/17 / #20170252058

Placid wire mechanism of penetrating blockings and occlusions in arteries

An arterial blockage percussive drill having a guiding sleeve, a drilling wire slidably coupled to the guiding sleeve and a percussive actuator coupled to the drilling wire to longitudinally oscillate the drilling wire into an arterial blockage.... California Institute Of Technology

09/07/17 / #20170252729

Germanosilicate compositions and methods of preparing the same

The present disclosure is directed to novel germanosilicate compositions and methods of producing the same. In particular, this disclosure describes an array of transformations originating from the extra-large-pore crystalline germanosilicate compositions, designated CIT-13, possessing 10- and 14-membered rings. Included among the new materials are the new phyllosilicate compositions, designated CIT-13P,... California Institute Of Technology

08/31/17 / #20170246961

Adaptive charging network using adaptive charging stations for electric vehicles

Adaptive charging networks in accordance with embodiments of the invention enable the optimization of electric design of charging networks for electric vehicles. One embodiment includes an electrical supply; a plurality of adaptive charging stations; wherein at least one adaptive charging station distributes power to at least one other adaptive charging... California Institute Of Technology

08/31/17 / #20170247725

In vivo and in vitro olefin cyclopropanation catalyzed by heme enzymes

The present invention provides methods for catalyzing the conversion of an olefin to any compound containing one or more cyclopropane functional groups using heme enzymes. In certain aspects, the present invention provides a method for producing a cyclopropanation product comprising providing an olefinic substrate, a diazo reagent, and a heme... California Institute Of Technology

08/31/17 / #20170249420

Methods and systems for predicting membrane protein expression based on sequence-level information

Membrane protein expression can be predicted using statistical frameworks to provide an enhanced subset of sequences, out of an initial larger set of potentially expressing sequences, by using features derived from sequences and a model parameterized through a dataset of known expression levels. Also, membrane protein experimentation protocols can be... California Institute Of Technology

08/31/17 / #20170250048

Nanoscale field-emission device and fabrication

Nanoscale field-emission devices are presented, wherein the devices include at least a pair of electrodes separated by a gap through which field emission of electrons from one electrode to the other occurs. The gap is dimensioned such that only a low voltage is required to induce field emission. As a... California Institute Of Technology

08/24/17 / #20170240571

Stable silylating reagents

The present invention is directed to compositions for silylating organic substrates containing C—H or O—H bonds, especially heteroaromatic substrates. The compositions are derived from the preconditioning of mixtures of hydrosilanes or organodisilanes with bases, including metal hydroxide and metal alkoxide bases. In some embodiments, the preconditioning results in the formation... California Institute Of Technology

08/24/17 / #20170240885

Selective recovery

Provided herein are methods of selective screening. In addition, various targeting proteins and sequences, as well as methods of their use, are also provided.... California Institute Of Technology

08/24/17 / #20170244410

Method and simultaneous processing of multiple functions

... California Institute Of Technology

08/17/17 / #20170232092

Methods and compositions for t cell generation and uses thereof

Among the various aspects of the present disclosure is the provision of a method of treating an inflammatory bowel disease. Another aspect provides the provision of a screening method for therapeutic agents. Another aspect provides a method of detecting Treg cells to determine if a subject has an inflammatory disease.... California Institute Of Technology

08/17/17 / #20170233668

Associative polymers to control formation of particulate matter from ignitable compositions and related compositions, methods and systems

Described herein are associative polymers capable of controlling formation of particulate matter from a non-polar ignitable composition upon ignition of the non-polar ignitable composition, alone or in combination with control of a physical and/or chemical property of the non-polar compositions and related compositions, methods and systems. Associative polymers herein described... California Institute Of Technology

08/17/17 / #20170234984

Hybrid transmitter receiver optical imaging system

An image capture device includes, in part, N optical transmit antennas forming a first array, N phase modulators each associated with and adapted to control a phase of a different one of the transmit antennas, M optical receive antennas forming a second array, M phase modulators each associated with and... California Institute Of Technology

08/10/17 / #20170225161

The pumping lid: devices and methods for programmable generation of positive and negative pressures

Provided herein are devices and methods for generating positive and negative pressures. The devices and methods are suited for the generation of pressures; in particular, the pressures generated can be useful for controlling the flow of fluids, such as in fluidic device.... California Institute Of Technology

08/10/17 / #20170226063

Dna2 inhibitors for cancer treatment

Disclosed herein, inter alia, are compositions and methods for inhibiting DNA2.... California Institute Of Technology

08/10/17 / #20170226619

Systems and methods implementing layers of devitrified metallic glass-based materials

Systems and methods in accordance with embodiments of the invention implement layers of devitrified metallic glass-based materials. In one embodiment, a method of fabricating a layer of devitrified metallic glass includes: applying a coating layer of liquid phase metallic glass to an object, the coating layer being applied in a... California Institute Of Technology

08/03/17 / #20170218021

Botulinum neurotoxin-specific capture agents, compositions, and methods of using and making

The present application provides stable peptide-based Botulinum neurotoxin (BoNT) serotype A capture agents and methods of use as detection and diagnosis agents and in the treatment of diseases and disorders. The application further provides methods of manufacturing BoNT serotype A capture agents using iterative on-bead in situ click chemistry.... California Institute Of Technology

08/03/17 / #20170218346

Heme protein catalysts for carbon-silicon bond formation in vitro and in vivo

The present invention provides compositions and methods for catalyzing the formation of carbon-silicon bonds using heme proteins. In certain aspects, the present invention provides heme proteins, including variants and fragments thereof, that are capable of carrying out in vitro and in vivo carbene insertion reactions for the formation of carbon-silicon... California Institute Of Technology

08/03/17 / #20170219999

Compact digital holographic microscope for planetary imaging or endoscopy

In situ investigation of microbial life in extreme environments can be carried out with microscopes capable of imaging 3-dimensional volumes and tracking particle motion. A lensless digital holographic microscope is disclosed that provides roughly 1.5 micron resolution in a compact, robust package suitable for remote deployment. High resolution is achieved... California Institute Of Technology

08/03/17 / #20170222720

Optical communication systems

A receiver, transmitter, and photon counting detector for use in an optical communication link are disclosed. Also disclosed are methods of communicating using the transmitter, the receiver, and the photon detector.... California Institute Of Technology

07/27/17 / #20170209045

System and intraocular pressure sensing

IOP sensor and system for measuring intraocular pressure are disclosed herein. Examples embodiments of the IOP sensor can include: a chamber having a first wall and a second wall opposing the first wall; a first array of photonic components disposed inside of the chamber; a raised portion located within the... California Institute Of Technology

Patent Packs
07/27/17 / #20170209046

Non-invasive measurement of intraocular pressure

Devices, systems and methods are described for non-invasively monitoring and/or measuring or estimating intraocular pressure. Medical or diagnostic methods embodiments described herein include high resolution imaging of the sclera of one or both of a patient's eyes using digital photography or videography. The hardware employed may be for two-dimensional (2D)... California Institute Of Technology

07/27/17 / #20170210834

Co-supported catalysts for the tandem trimerization and polymerization of ethylene to produce linear low density polyethylene

Linear low density polyethylene (LLDPE) is produced from an ethylene-only feed over a tandem catalyst system consisting of a phenoxy-imine titanium trimerization catalyst and a silylene-linked cyclopentadienyl/amido titanium polymerization catalyst co-supported on the same methylaluminoxane/silica particles. The level of 1-hexene incorporation in the LLDPE can be controlled by varying the... California Institute Of Technology

07/27/17 / #20170212285

Dispersionless and dispersion-controlled optical dielectric metasurfaces

Metasurfaces comprise an array of pillars in a lattice. The dimensions of the pillars and the spacing are varied to obtain desired optical properties. The dispersionless metasurfaces can focus optical light over a broad wavelength range. Specific dispersion profiles for the metasurfaces can be designed. Gratings can be fabricated having... California Institute Of Technology

07/27/17 / #20170212983

Error correction of multiplex imaging analysis by sequential hybridization

Disclosed herein are methods and systems for detecting and/or quantifying cellular targets such as nucleic acids in cells, tissues, organs or organisms. Through sequential barcoding, it is possible to perform high-throughput profiling of a large number of targets, such as transcripts and/or DNA loci. In some embodiments, error correction is... California Institute Of Technology

07/27/17 / #20170213047

Secure raid schemes for distributed storage

Disclosed are low-complexity schemes to store information in a distributed manner across multiple nodes of a computer system. The schemes are resilient to node failures and resistant to node eavesdropping. The disclosed schemes may be used in conjunction with RAID systems, and when used in such systems may be referred... California Institute Of Technology

07/27/17 / #20170214083

Vertical carbon nanotube and lithium ion battery chemistries, articles, architectures and manufacture

Features for rechargeable lithium ion batteries, the batteries optionally employing vertically aligned carbon nanotube scaffolding, are described. Methods of manufacture and a solid polymer electrolyte are described for 3-dimensional battery architectures using the vertically aligned carbon nanotubes. Poly(ethylene)oxide bis(azide) and graphene poly(lactic acid) composite coatings are also described for use... California Institute Of Technology

07/20/17 / #20170204144

Selective recovery

Provided herein are methods of selective screening. In addition, various targeting proteins and sequences, as well as methods of their use, are also provided.... California Institute Of Technology

07/13/17 / #20170199104

Whole-body tissue stabilization and selective extractions via tissue-hydrogel hybrids for high resolution intact circuit mapping and phenotyping

In various embodiments, the present application teaches methods for tissue clearing in which tissues are rendered macromolecule-permeable and optically-transparent, thereby exposing their cellular structure with intact connectivity. In some embodiments, the present application teaches ePACT, which is a protocol for enhanced tissue clearing via expansion. In some embodiments, the present... California Institute Of Technology

07/06/17 / #20170188901

Planar diffractive device with matching diffraction spectrum

A solution containing a target molecule and a reference molecule is illuminated to obtain Raman signals. An optical metasurface is used as a diffractive optical element to split the Raman signal from the target molecule and the Raman signal from the reference molecule. The target and reference Raman signals can... California Institute Of Technology

07/06/17 / #20170189444

Polymeric compositions and related regulating biological hydrogels

Polymeric composition and related methods and systems for regulating the structure of hydrogels are described. In particular, by varying the physiochemical properties of the polymeric composition, the structure of the hydrogels can be reversibly compressed or decompressed.... California Institute Of Technology

07/06/17 / #20170189530

Photoactivated molecules for light induced modulation of the activity of electrically excitable cells and methods of using the same

Disclosed herein are methods and compositions for the modulation of the activity of electrically excitable cells. In particular, several embodiments relate to the use of photovoltaic compounds which, upon exposure to light energy, increase or decrease the electrical activity of cells.... California Institute Of Technology

07/06/17 / #20170192011

Ligand discovery for t cell receptors

Compositions and methods are provided for the identification of peptide sequences that are ligands for a T cell receptor (TCR) of interest, in a given MHC context.... California Institute Of Technology

07/06/17 / #20170193688

Systems and methods for data visualization using three-dimensional displays

Data visualization systems and methods for generating 3D visualizations of a multidimensional data space are described. In one embodiment a 3D data visualization application directs a processing system to: load a set of multidimensional data points into a visualization table; create representations of a set of 3D objects corresponding to... California Institute Of Technology

07/06/17 / #20170193830

Controlling unmanned aerial vehicles to avoid obstacle collision

A method, device, framework, and system provide the ability to control an unmanned aerial vehicle (UAV) to avoid obstacle collision. Range data of a real-world scene is acquired using range sensors (that provide depth data to visible objects). The range data is combined into an egospace representation (consisting of pixels... California Institute Of Technology

07/06/17 / #20170194546

Skutterudite thermoelectric materials and methods for making

The present invention provides a thermoelectric device. The thermoelectric device includes an interconnect layer, a skutterudite layer, and a metallization stack. The metallization stack, having a diffusion layer, is disposed between and in electrical contact with the interconnect layer and the skutterudite layer of the thermoelectric device. The present invention... California Institute Of Technology

Patent Packs
07/06/17 / #20170194713

Microwave reflector link, and cdma-spread spectrum reflector reduction of unmodulated ambient blockers in reflected data links

A system, apparatus and method are disclosed for communicating between a short range wireless (WLAN) user device, such as a wearable, phone, or tablet, with a base station. Traditional low power communication (e.g., WLAN, WiFi, Bluetooth, cellular links, etc.) involve an inefficient amplification process of a signal from the WLAN... California Institute Of Technology

06/29/17 / #20170181643

Noninvasive systems for blood pressure measurement in arteries

Hardware and software methodology are described for a non-invasive approach to blood pressure measurement in pulmonary artery and systemic arteries by using wall displacement and blood velocity that are measured using ultrasound, microwave techniques and/or other radiofrequency (RF) techniques.... California Institute Of Technology

06/29/17 / #20170183277

Molecular sieves mediated unsaturated hydrocarbon separation and related compositions, materials, methods and systems

Described herein are compositions having an eight-membered monocyclic unsaturated hydrocarbon, methods and system to separate the eight-membered monocyclic unsaturated hydrocarbon from a hydrocarbon mixture including additional nonlinear unsaturated C8H2m hydrocarbons with 4≦m≦8, by contacting the hydrocarbon mixture with a 10-ring pore molecular sieve having a sieving channel with a 10-ring... California Institute Of Technology

06/22/17 / #20170174648

Synthetic route to anhydroryanodol, ryanodol and structural analogues

This disclosure is related to methods for producing anhydroryanodol, ryanodol, or analogues thereof and novel compounds prepared thereby.... California Institute Of Technology

06/22/17 / #20170179879

Temperature-staged thermal energy storage enabling low thermal exergy loss reflux boiling in full spectrum solar energy systems

The efficiency of solar power collection is increased by adding a thermal energy storage stage to a sunlight concentrator and thermodynamic power generator system. The thermal energy storage includes tubes or capsules made of a phase change material that stores thermal energy in different temperature stages through a working fluid.... California Institute Of Technology

06/15/17 / #20170164831

System and measuring intraocular pressure

IOP sensors and IOP measurement algorithms are disclosed herein. Examples of the IOP measurement algorithm can include a signal demodulation and artificial neural network algorithm to produce reliable results using minimal computational resources. The overall accuracy and speed of the IOP sensors and measurement algorithms enable their implementation in home-based... California Institute Of Technology

06/15/17 / #20170165506

Targeting cancer cells selectively via resonant harmonic excitation

Systems and methods for targeting specific cell types by selective application of ultrasonic harmonic excitation at their resonance frequency (“oncotripsy”) are presented. The systems and methods result in the lysis of targeted cell types by using ultrasonic harmonic excitations that have been specifically tuned to disrupt the nuclear membrane of... California Institute Of Technology

06/15/17 / #20170166926

Targeting peptides for directing adeno-associated viruses (aavs)

Disclosed herein are peptide sequences capable of directing adeno-associated viruses (AAV) to target specific environments, for example the nervous system and the heart, in a subject. Also disclosed are AAVs having non-naturally occurring capsid proteins comprising the disclosed peptide sequences, and methods of using the AAVs to treat diseases.... California Institute Of Technology

06/15/17 / #20170167800

Silicon biporous wick for high heat flux heat spreaders

A wicking structure comprising a biporous wick formed with a semiconductor (e.g., silicon), wherein the biporous wick comprises first pores and second pores formed by the semiconductor and the first pores are larger than the second pores.... California Institute Of Technology

06/15/17 / #20170168233

Integrated two-dimensional planar optical phased array

An optical phased array includes, in part, a multitude of optical signal emitters and a multitude of optical signal phase/delay elements each associated with and disposed between a different pair of the optical signal emitters. Each optical signal phase/delay element is adapted to cause a phase/delay shift between the optical... California Institute Of Technology

06/15/17 / #20170169949

Micro- and nanoscale capacitors that incorporate an array of conductive elements having elongated bodies

Systems and methods in accordance with embodiments of the invention implement micro- and nanoscale capacitors that incorporate a conductive element that conforms to the shape of an array elongated bodies. In one embodiment, a capacitor that incorporates a conductive element that conforms to the shape of an array of elongated... California Institute Of Technology

06/08/17 / #20170157389

Parylene-based microelectrode array implant for spinal cord stimulation

An implantable electrode array assembly configured to apply electrical stimulation to the spinal cord. A substantially electrically nonconductive layer of the device has a first portion positionable alongside the spinal cord that includes a plurality of first openings. The layer has a second portion that includes a plurality of second... California Institute Of Technology

06/08/17 / #20170161554
06/01/17 / #20170152541

Reduction of oxidated methionine peptides for mass spectrometry

A method for preparing a methionine-containing peptide or protein for analysis by mass spectrometry includes incubating the methionine-containing peptide or protein with a heterologous methionine sulfoxide reductase A (MsrA), MsrB, or MsrAB enzyme resulting in the reduction of oxidized methionine-containing peptides or proteins.... California Institute Of Technology

06/01/17 / #20170152553

Enhanced nucleic acid identification and detection

The present invention relates to assays, including amplification assays, conducted in the presence of modulators. These assays can be used to detect the presence of particular nucleic acid sequences. In particular, these assays can allow for genotyping or other genetic analysis.... California Institute Of Technology

06/01/17 / #20170152588
05/25/17 / #20170144225

Systems and methods for fabricating objects including amorphous metal using techniques akin to additive manufacturing

Systems and methods in accordance with embodiments of the invention fabricate objects including amorphous metals using techniques akin to additive manufacturing. In one embodiment, a method of fabricating an object that includes an amorphous metal includes: applying a first layer of molten metallic alloy to a surface; cooling the first... California Institute Of Technology

05/18/17 / #20170136463

Microfluidic device

Described herein are particular embodiments relating to a microfluidic device that may be utilized for cell sensing, counting, and/or sorting. Particular aspects relate to a microfabricated device that is capable of differentiating single cell types from dense cell populations. One particular embodiment relates a device and methods of using the... California Institute Of Technology

05/18/17 / #20170137382

Quaternary heteroatom containing compounds

with a transition metal catalyst and under alkylation conditions as valence and stability permit.... California Institute Of Technology

05/18/17 / #20170137955

Method for embedding inserts, fasteners and features into metal core truss panels

Systems and method for fabricating a metal core truss panel with seamlessly embedded features in accordance with embodiments of the invention are illustrated. One embodiment includes a method for producing a metal core truss panel composite, the method including fabricating a sacrificial core truss panel including a plurality of interconnected... California Institute Of Technology

05/18/17 / #20170138942

Arrays, substrates, devices, methods and systems for detecting target molecules

Arrays and substrates comprising a material, in particular capture agents and/or detectable targets, attached to the substrates along substantially parallel lines forming a barcoded pattern and related methods and systems.... California Institute Of Technology








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