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Case Western Reserve University patents


Recent patent applications related to Case Western Reserve University. Case Western Reserve University is listed as an Agent/Assignee. Note: Case Western Reserve University may have other listings under different names/spellings. We're not affiliated with Case Western Reserve University, we're just tracking patents.

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Case Western Reserve University

. . ... Case Western Reserve University

Methods of modulating mrna stability and protein expression

A synthetic cdna which encodes a protein wherein at least one optimal or non-optimal codon in a wild type dna encoding the protein has been replaced respectively with one or more non-optimal codons or optimal codons encoding the same amino acid.. . ... Case Western Reserve University

Devices and methods for production of hollow cylindrical structures and hollow cylindrical structures

A device suitable for constructing hollow cylindrical structures, particularly useful as medical devices. The devices are versatile in nature and can fabricate hollow cylindrical structures having single or multiple layers of one or more different materials, including biomaterials. ... Case Western Reserve University

Ti-based filler alloy compositions

Alloys comprising titanium as the principal component and which melt between 700 and 1400 degrees c. Are disclosed to have favorable characteristics for braze-joining. ... Case Western Reserve University

Cancer immunotherapy using virus particles

A method of treating cancer in a subject in need thereof includes administering in situ to the cancer a therapeutically effective amount of a virus or virus-like particle.. . ... Case Western Reserve University

Histomorphometric classifier to predict cardiac failure from whole-slide hematoxylin and eosin stained images

Methods, apparatus, and other embodiments predict heart failure from wsis of cardiac histopathology using a deep learning convolutional neural network (cnn). One example apparatus includes a pre-processing circuit configured to generate a pre-processed wsi by downsampling a digital wsi; an image acquisition circuit configured to randomly select a set of non-overlapping rois from the pre-processed wsi, and configured to provide the set of non-overlapping rois to a deep learning circuit; a deep learning circuit configured to generate an image-level probability that a member of the set of non-overlapping rois is a failure/abnormal pathology roi using a cnn; and a classification circuit configured to generate a patient-level probability that the patient from which the region of tissue represented in the wsi was acquired is experiencing failure or non-failure based, at least in part, on the image-level probability.. ... Case Western Reserve University

N-doped carbon nanomaterials as catalysts for oxygen reduction reaction in acidic fuel cells

Provided is a membrane electrode assembly and a fuel cell comprising such assemblies. The membrane electrode assembly comprises a polymer electrolyte membrane disposed between an anode and a cathode, the cathode comprising a metal-free, heteroatom doped carbon based material. ... Case Western Reserve University

Suspending proppants with polymerized hydrogels

Hydrogel-coated proppants and methods for manufacture thereof. In preferred embodiments, the hydrogel coating is covalently attached and crosslinked to the proppant substrate in a core-shell structure. ... Case Western Reserve University

Activation map based individualized planning for deep brain stimulation

Example apparatus and methods plan and control neuro-modulation of a distributed multi-region network in a brain. A location for a deep brain stimulation (dbs) electrode that participates in activating a combination of white matter pathways associated with the network is selected. ... Case Western Reserve University

Therapy delivery devices and methods for non-damaging neural tissue conduction block

Devices and methods for blocking signal transmission through neural tissue. One step of a method includes placing a therapy delivery device into electrical communication with the neural tissue. ... Case Western Reserve University

Method for forming a thin film comprising an ultrawide bandgap oxide semiconductor

A method is disclosed for depositing a high-quality thin films of ultrawide bandgap oxide semiconductors at growth rates that are higher than possible using prior-art methods. Embodiments of the present invention employ lpcvd deposition using vapor formed by evaporating material as a precursor, where the material has a low vapor pressure at the growth temperature for the thin film. ... Case Western Reserve University

Protein biomarkers and therapeutic targets for renal disorders

The present invention relates to a method of diagnosing a renal disorder. The method includes the steps of: (1) obtaining a biological sample from a subject; and (2) determining, in the biological sample, a level of one or more proteins whose abundance in urine change due to the renal disorder, wherein an increase or decrease in the level of one or more of the proteins compared to a control level is indicative of a renal disorder.. ... Case Western Reserve University

Extracellular vesicle-based diagnostics and engineered exosomes for targeted therapeutics against cancer

This invention is related to use of exosomes for biomarker analysis for early detecting and characterizing of disease progression of cancer. Further, the invention provides bioengineered exosomes for use in methods of targeting and treating cancer.. ... Case Western Reserve University

Metal-free bifunctional electrocatalyst for oxygen reduction and oxygen evolution reactions

A co-doped carbon material, methods of making such materials, and electrochemical cells and devices comprising such materials are provided. The co-doped carbon material comprises a mesoporous carbon material doped with nitrogen and phoshporous (npmc). ... Case Western Reserve University

03/29/18 / #20180085587

Onset-mitigating high-frequency nerve block

A method of blocking signal transmission through a nerve with reduced onset activity includes applying an hfac to an axon of a nerve to block the transmission of signals through the axon. The method may also include applying a direct current (dc) to the axon, increasing the amplitude of the dc over time to a predetermined amplitude, applying the hfac, and then decreasing the dc. ... Case Western Reserve University

03/15/18 / #20180071368

Synthetic platelets

A method of promoting hemostasis in a subject in need thereof includes administering to the subject a biocompatible flexible nanoparticle that includes an outer surface and a plurality of peptides conjugated to the surface, wherein the peptides include a plurality of von willebrand factor-binding peptides (vbps), collagen-binding peptides (cbps) and an active platelet gpm-ma-binding peptides (gbps).. . ... Case Western Reserve University

03/15/18 / #20180071285

Systems pharmacology for treating ocular disorders

A method of treating an ocular disorder in a subject includes administering to the subject subtherapeutic amounts of two or more agents that inhibit and/or blocks the activation of gs- or gq-protein coupled receptors or gs- or gq-signaling cascade in ocular cells of the subject, and/or activates gi-protein coupled receptors, which is induced or triggered by light induced all-trans-retinal generation.. . ... Case Western Reserve University

03/08/18 / #20180067179

Differential atlas for cancer assessment

Methods and apparatus associated with producing a quantification of differences associated with biochemical recurrence (bcr) in a region of tissue demonstrating prostate cancer (pca) are described. One example apparatus includes a set of logics, and a data store that stores a set of magnetic resonance (mr) images acquired from a population of subjects. ... Case Western Reserve University

03/08/18 / #20180067130

Pglyrp2 biomarker in idiopathic pneumonia syndrome

A method for characterizing the risk a subject will develop an autoimmune and/or alloimmune disease following tissue transplant includes obtaining a biological sample from the subject, wherein the subject has received the tissue transplant determining in the biological sample a level of at least one protein selected from tables 1-4, comparing the measured level of the at least one protein to a control value, and characterizing a subject as at greater risk of developing an autoimmune disease and/or alloimmune disease if the level of at least one protein determined is increased or decreased compared to the control value.. . ... Case Western Reserve University

03/08/18 / #20180064815

Photocrosslinked biodegradable hydrogel

A photocrosslinked biodegradable hydrogel includes a plurality of natural polymer macromers cross-linked with a plurality of hydrolyzable acrylate cross-links. The hydrogel is cytocompatible and produces substantially non-toxic products upon degradation.. ... Case Western Reserve University

03/08/18 / #20180064694

Inhibitors of short-chain dehydrogenase activity for treating fibrosis

A method of treating or preventing a fibrotic disease, disorder or condition includes administering to a subject in need of treatment a 15-pgdh inhibitor.. . ... Case Western Reserve University

03/01/18 / #20180059020

Optical sensor platform employing hyperbolic metamaterials

Disclosed herein are optical sensor platform(s) employing hyperbolic metamaterial(s) supporting highly confined bulk plasmon guided modes over broad wavelength range(s) from visible to near-infrared. By exciting these modes using—for example—a two-dimensional (2d) grating-coupling technique, sensors according to the present disclosure advantageously exhibit extreme sensitivity modes up to a maximum of 30,000 nm per refractive index unit and a record figure of merit of 590 thereby permitting detection of ultralow-molecular-weight bio-molecules at picomolar concentrations.. ... Case Western Reserve University

03/01/18 / #20180057887

Her2-regulated rna as a diagnostic and therapeutic targets in her2+ breast cancer

A method for treating her2 positive breast cancer in a subject in need thereof includes administering to cancer cells of the subject an agent effective to modulate the level of her2-associated rna in the breast cancer cells of the subject.. . ... Case Western Reserve University

03/01/18 / #20180057559

Insulin analogues with a glucose-regulated conformational switch

A two-chain insulin analogue contains an a chain modified by (i) a monomeric glucose-binding element at or near its n terminus and (ii) a b chain modified by at or near its c terminus by an element that reversibly binds to the monomeric glucose-binding element such that this linkage is displaceable by glucose. The monomeric glucose-binding element may be phenylboronic acid derivative (optionally halogenated). ... Case Western Reserve University

03/01/18 / #20180057371

Detection and removal of selenate from aqueous solution

Systems and methods for detecting and/or removing selenate from an aqueous selenate-containing solution are described. The method includes adding sufficient acid to the aqueous selenate-containing solution to acidify the aqueous selenate-containing solution; contacting the acidic aqueous selenate-containing solution with an underpotantial deposited copper-coated electrode; and removing selenate from the aqueous selenate-containing solution by forming copper-selenide on the underpotential copper-coated electrode.. ... Case Western Reserve University

02/22/18 / #20180051259

Cell fate conversion of differentiated somatic cells into glial cells

The present invention relates to the reprogramming of differentiated somatic cells, such as those differentiated cells that arise from embryonic mesoderm, into glial cells. Glial cells produced from this reprogramming are functionally equivalent to glial cells that arise from ectodermal origins.. ... Case Western Reserve University

02/22/18 / #20180050068

Metastatic cancer decoy trap

A method of treating or preventing cancer metastasis in a subject is described. The method includes implanting a decoy trap within the subject, the decoy trap comprising an implantable trap device including a metastatic cancer attractant. ... Case Western Reserve University

02/15/18 / #20180043291

Multilayer cellular membranes for filtration applications

A filter includes a fibrous substrate having a plurality of coextruded first polymer material fibers and second polymer material fibers. Each of the first and second fibers are separated from each other and have a rectangular cross-section defined in part by an additional encapsulating polymer material that is separated from the first polymer material fibers and second polymer material fibers. ... Case Western Reserve University

02/15/18 / #20180042565

Dual energy x-ray coronary calcium grading

Methods and apparatus for grading coronary calcium, including an example apparatus that includes a set of logics and a memory that stores a set of radiographic images. The set of logics includes an image acquisition logic that acquires a set of radiographic images of a region of tissue, the set of radiographic images including a low-energy reference x-ray image and a higher-energy floating x-ray image, a registration logic that produces a set of registered images from a plurality of members of the set of radiographic images, an enhancement logic that produces a set of calcium-enhanced images from the set of registered images, a post-enhancement logic that produces a bone image from the set of calcium-enhanced images, and a grading logic that computes a coronary heart disease prediction score based, at least in part, on the bone image and a set of features extracted from the bone image.. ... Case Western Reserve University

02/08/18 / #20180035939

Low frequency non-invasive sensorial stimulation for seizure control

Example apparatus and methods reduce epileptic seizures in a human patient by non-invasively providing low frequency (e.g., 1-10 hz) audio stimuli coordinated with low frequency (e.g., 1-10 hz) visual stimuli to the patient. The signals are provided non-invasively through the eyes and ears. ... Case Western Reserve University

02/01/18 / #20180033937

Thermoelectric energy harvesting from pavement structure

Electrically parallel thermoelectric modules (tems), especially induced multilayered tems, have the potential to stimulate the applications of tems to harvest energy from naturally existing temperature gradients, because of the convenience and cost-effectiveness to fabricate large area devices. A thermoelectric-based system comprises a thermoelectric module comprising an upper surface and a lower surface, said upper surface being separated from said lower surface by a “n” type material, or a “p” type material, or both; a thermally conductive plate, being located beneath said thermoelectric module, said plate being capable of transferring heat from said thermoelectric module lower surface via a thermally conductive leg to a heat sink, and said system capable of being located in a pavement having a temperature gradient and being capable of generating electricity therefrom.. ... Case Western Reserve University

02/01/18 / #20180033138

Entropy-based radiogenomic descriptors on magnetic resonance imaging (mri) for molecular characterization of breast cancer

Methods, apparatus, and other embodiments distinguish disease phenotypes and mutational status using co-occurrence of local anisotropic gradient orientations (coliage) and laws features. One example apparatus includes a set of circuits that acquires a radiologic image (e.g., mri image) of a region of tissue demonstrating breast cancer, computes a gradient orientation for a pixel in the mri image, computes a significant orientation for the pixel based on the gradient orientation, constructs a feature vector that captures a discretized entropy distribution for the image based on the significant orientation, extracts a set of texture features from the mri image, and classifies the phenotype of the breast cancer based on the feature vector and the set of texture features. ... Case Western Reserve University

02/01/18 / #20180030145

Methods of detecting cancer

A method of detecting the presence of glioblastomas and/or recurrent glioblastomas in a subject in need thereof includes isolating cd14+ cells from a blood sample of the subject and determining the ratio of isolated cd14+ cells expressing low levels of hla-dr to isolated cd14+ cells expressing vnn2, wherein the subject has increased risk of glioblastomas or recurrent glioblastoma if the ratio of isolated cd14+ cells expressing low levels of hla-dr to isolated cd14+ cells expressing vnn2 is greater than about 2.. . ... Case Western Reserve University

01/25/18 / #20180025490

Multi-pass adaptive voting for nuclei detection in histopathological images

Methods, apparatus, and other embodiments detect nuclei in histopathological images. One example method includes accessing a histopathology image that includes a plurality of pixels, generating a gradient field map based on the histopathology image, generating a refined gradient field map based on the gradient field map, calculating a voting map for a member of the plurality of pixels based, at least in part, on the refined gradient field map and a voting kernel, generating an aggregated voting map based on the voting map, computing a global threshold, and identifying a nuclear centroid based on the global threshold and the aggregated voting map.. ... Case Western Reserve University

01/25/18 / #20180025489

Quantifying mass effect deformation with structural radiomics in brain tumor patients

Methods and apparatus quantify mass effect deformation in diagnostic images of patients demonstrating glioblastoma multiforme (gbm). One example apparatus includes an image acquisition circuit that acquires an image of a region of tissue demonstrating gbm pathology, a delineation circuit that segments a tumor region from the image, a pre-processing circuit that generates a pre-processed image by pre-processing the segmented image, a registration circuit that registers the pre-processed image with a template image of a healthy brain, a deformation quantification circuit that computes a set of differences between a position of a brain sub-structure represented in the registered image relative to the position of the brain sub-structure represented in the template image. ... Case Western Reserve University

01/25/18 / #20180021277

Anti-virulence compositions and methods

A method of treating a bacterial infection in a subject in need thereof includes administering to the subject an agra antagonist.. . ... Case Western Reserve University

01/18/18 / #20180015281

System and method for ensuring airway patency when asleep

One aspect of the present disclosure relates to a system that provides an alternative to traditional treatments for sleep apnea. The system allows to apply an electrical stimulus through an electrode to stimulate an afferent nerve fiber while a patient is sleeping. ... Case Western Reserve University

01/11/18 / #20180012356

Disease characterization from fused pathology and radiology data

Methods and apparatus distinguish invasive adenocarcinoma (ia) from in situ adenocarcinoma (ais). One example apparatus includes a set of circuits, and a data store that stores three dimensional (3d) radiological images of tissue demonstrating ia or ais. ... Case Western Reserve University

01/11/18 / #20180008559

Compositions and methods for the treatment of pervasive development disorders

A method of treating a pervasive development disorder in a subject includes administering to the subject a therapeutically effective amount of an nmdar antagonist, with an intermittent dosing regimen.. . ... Case Western Reserve University

01/04/18 / #20180000769

Compositions and methods for stimulating ventilatory and/or respiratory drive

A method of stimulating ventilatory and/or respiratory drive in a subject in need thereof includes administering to the subject a therapeutically effective amount of a composition comprising a cystine ester or a pharmaceutically acceptable salt thereof. Embodiments described herein relate to compositions and methods of stimulating ventilatory and/or respiratory drive in a subject in need thereof, and particularly relates to compositions and methods of treating breathing diseases and/or disorders associated with paired ventilatory and/or respiratory drive.. ... Case Western Reserve University

12/28/17 / #20170369948

Methods and compositions for detecting colorectal neoplasias

The disclosure provides methods for identifying genomic loci that are differentially methylated in colorectal neoplasias. Identification of methylated genomic loci has numerous uses, including for example, to characterize disease risk, to predict responsiveness to therapy, to non-invasively diagnose subjects and to treat subjects determined to have colorectal neoplasias.. ... Case Western Reserve University

12/28/17 / #20170369548

Insulin analogues with selective signaling properties and reduced mitogenicity

A two-chain insulin analogue contains aspartic acid at position b10 and penta-fluoro-phenylalanine at position b24, optionally histidine or glutamic acid at position a8, optionally additional substitutions or modifications at positions a13 and/or a14 and/or b28 and/or b29. The analogue may be an analogue of a mammalian insulin, such as human insulin, may optionally include (i) n-terminal deletion of one, two or three residues from the b chain, (ii) a mono-peptide or dipeptide c-terminal extension of the b-chain containing at least one acidic residue, and (iii) other modifications known in the art to enhance the stability of insulin. ... Case Western Reserve University

12/28/17 / #20170369322

Ketyl radical induced photoreduction of graphene oxide; grafting of metal nanoparticles on graphene by photoreduction

Photoreduction of graphene oxide, by uv-generated ketyl radicals, to graphene. The photoreduction is versatile and can be carried out in solution, solid-state, and even in polymer composites. ... Case Western Reserve University

12/21/17 / #20170360895

Long-acting insulin analogue preparations in insoluble and crystalline forms

A pharmaceutical formulation comprises an insulin analogue or a physiologically acceptable salt thereof, wherein the insulin analogue or a physiologically acceptable salt thereof contains an insulin a-chain sequence that contains paired histidine substitutions at a4 and a8, and optionally a substitution at a21. The formulation further contains a pharmaceutically acceptable buffer containing at least about 4 zinc ions per 6 insulin analogue molecules. ... Case Western Reserve University

12/21/17 / #20170360755

Compositions and methods of modulating s-nitrosylation

A method of treating disorders associated with no/sno deficiency or benefiting from increased sno in a subject in need thereof includes administering to the subject an adh inhibitor, akr inhibitor, sno-coar inhibitor, and/or sno-coa at an amount(s) effective to promote s-nitrosylation of proteins in the subject.. . ... Case Western Reserve University

12/07/17 / #20170352157

Computerized analysis of computed tomography (ct) imagery to quantify tumor infiltrating lymphocytes (tils) in non-small cell lung cancer (nsclc)

Methods, apparatus, and other embodiments predict tumor infiltrating lymphocyte (til) density from pre-surgical computed tomography images of a region of tissue demonstrating non-small cell lung cancer (nsclc). One example apparatus includes a set of circuits that includes an image acquisition circuit that accesses a radiological image of a region of tissue demonstrating cancerous pathology, where the radiological image has a plurality of pixels, and where the radiological image includes an annotated region of interest (roi), a feature extraction circuit that extracts a set of radiomic features from the roi, where the set of radiomic features includes at least two texture features and at least one shape feature, and a classification circuit that comprises a machine learning classifier that classifies the roi as high tumor infiltrating lymphocyte (til) density, or low til density, based, at least in part, on the set of radiomic features.. ... Case Western Reserve University

12/07/17 / #20170351939

Predicting response to pemetrexed chemotherapy in non-small cell lung cancer (nsclc) with baseline computed tomography (ct) shape and texture features

Methods, apparatus, and other embodiments predict response to pemetrexed based chemotherapy. One example apparatus includes an image acquisition circuit that acquires a radiological image of a region of tissue demonstrating nsclc that includes a region of interest (roi) defining a tumoral volume, a peritumoral volume definition circuit that defines a peritumoral volume based on the boundary of the roi and a distance, a feature extraction circuit that extracts a set of discriminative tumoral features from the tumoral volume, and a set of discriminative peritumoral features from the peritumoral volume, and a classification circuit that classifies the roi as a responder or a non-responder using a machine learning classifier based, at least in part, on the set of discriminative tumoral features and the set of discriminative peritumoral features.. ... Case Western Reserve University

11/30/17 / #20170340581

Compounds and methods of treating ocular disorders

A method of treating an ocular disorder in a subject associated with increased all-trans-retinal in an ocular tissue includes administering to the subject a therapeutically effective amount of a primary amine compound of formula (i); and pharmaceutically acceptable salts thereof.. . ... Case Western Reserve University

11/23/17 / #20170335998

Tubular, equipment and method of forming the same

A tubular including a plurality of first-type layers; and a plurality of second-type layers each disposed between a pair of adjacent first-type layers, wherein the plurality of first-type layers includes at least two first-type layers, wherein the plurality of second-type layers includes at least two second-type layers, and wherein a melt flow index, mfi1, of each of the plurality of first-type layers is different than a melt flow index, mfi2, of each of the plurality of second-type layers, as measured at a same temperature. In an embodiment, at least one of the first-type layers and the second-type layers is adapted to provide a barrier against escape of gases, liquids, or a combination thereof from the tubular.. ... Case Western Reserve University

11/23/17 / #20170332973

Multichannel ultra-low noise amplifier

The present disclose generally relates to a multichannel low-noise amplifier. At each input to the multichannel low-noise amplifiers, a plurality of transistors can be connected in parallel. ... Case Western Reserve University

11/09/17 / #20170319098

System and method for spectroscopic magnetic resonance fingerprinting

The present disclosure relates to a method for performing phosphorous-31 spectroscopic magnetic resonance fingerprinting (mrf). The method comprises performing a pulse sequence using a series of varied sequence blocks to a volume in a subject where the volume contains phosphate metabolites. ... Case Western Reserve University

10/26/17 / #20170309018

Automated intravascular plaque classification

Methods and apparatus automatically classify intravascular plaque using features extracted from intravascular optical coherence tomography (ivoct) imagery. One example apparatus includes an image acquisition circuit that accesses a set of ivoct images, a pre-processing circuit that generates a blood vessel mask based on the ivoct images, a feature extraction circuit that defines a three dimensional (3d) volume of interest centered on a location in a member of the set of ivoct images, a classification circuit that generates a classification based on a probability that a voxel represents a type of plaque, and a visualization circuit that provides a visualization, substantially in real time, of a member of the set of ivoct images and the classification, where the visualization includes a sector classification image, a labeled image, or a 3d visualization. ... Case Western Reserve University

10/26/17 / #20170304361

Halogenated insulin analogues of enhanced biological potency

An insulin molecule comprises an asp substitution at position b10, glu at one or more of positions corresponding to a8, b28, and b29, and a halogenated phenylalanine at position b24. The analogue may optionally include (i) n-terminal deletion of one, two or three residues from the b chain, (ii) a mono-peptide or dipeptide c-terminal extension of the b-chain containing at least one acidic residue, and (iii) other modifications known in the art to enhance the stability of insulin. ... Case Western Reserve University

10/12/17 / #20170293003

System and method for improved rf system performance in mri systems

An apparatus, a system, and a chip are provided for improving rf system performance in mri systems. The apparatus includes a radio-frequency (rf) coil array disposed at least partially in a coil housing, where the rf coil array may include at least one coil configured to receive magnetic resonance (mr) rf signals. ... Case Western Reserve University

10/05/17 / #20170281931

Nerve cuff for implantable electrode

A system for functional electrical stimulation can include a cuff and a stimulation device. The cuff can be attachable to a nerve or a muscle filament. ... Case Western Reserve University

09/21/17 / #20170268008

Diagnostic and therapeutic targeting of dnmt-1 associated rna in human cancer

A method for treating cancer in a subject in need thereof includes administering to cancer cells of the subject an agent effective to modulate the level of dnmt1-associated rna and/or the interaction of dnmt1-associated rna and dnmt1 in the cancer cells of the subject. Embodiments described herein relate to rnas (e.g., incrnas) associated with dna methyltransferase 1 (dnmti-associated rna) in human cancer cells, methods and compositions of modulating the levels of dnmti-associated rna and/or the interaction of dnmt1-associated rna and dnmt1 in cancer cells of the subject to treat cancer cells or a subject in need thereof, and/or methods of measuring the expression profile of dnmt1 associated rna to determine whether the subject has cancer or an increased risk of cancer and/or the efficacy of a therapeutic regimen agent.. ... Case Western Reserve University

09/21/17 / #20170266071

Fitting system and method for modular pressure relief cushion

A high-performance, low-cost modular cushion using range of novel dynamically responsive materials has been designed and developed for use in seating pressure relief. The use of individual contained spheres creates a localized area of gel to minimize both flattening under pressure, and inflating in areas without contact while the elastic nature of the polymers creates a durable system that recovers rapidly from deformation. ... Case Western Reserve University

09/21/17 / #20170265463

Sporicidal composition

A sporicidal composition includes an acidified short or medium chain, linear or branched alcohol having a ph effective to promote killing of spore forming bacteria and bacterial spores.. . ... Case Western Reserve University

09/14/17 / #20170260341

Cationic ultraviolet curing of resins with onium salt

Disclosed herein is a method of forming a photocurable polymer system. The method includes providing a polymer, providing a diaryl iodonium salt, blending said polymer and diaryl iodonium salt, applying the blend to a substrate; and crosslinking the blend. ... Case Western Reserve University

09/07/17 / #20170252326

Compositions and methods of inhibiting metallo-beta-lactamases

A method of treating a bacterial infection in a subject in need thereof includes administering to the subject therapeutically effective amounts of at least one β-lactam antibiotic and at least one bisthiazolidine metallo-β-lactamase inhibitor.. . ... Case Western Reserve University

08/31/17 / #20170248541

Sensor for volatile organic compound detection

A sensor for detecting volatile organic compounds (vocs) includes a substrate, a working electrode formed on a surface of the substrate, a counter electrode formed on the surface of the substrate, a dielectric layer covering a portion of the working electrode and counter electrode and defining an aperture exposing other portions of the working electrode and counter electrode.. . ... Case Western Reserve University

08/31/17 / #20170247801

Bromide removal from aqueous solutions

Systems and processes for removing and purifying bromide from an aqueous bromide solution are described. Electrochemistry is used to either convert bromide to bromine to allow its extraction in an organic phase, or to cause deposition of bromine onto an electrode. ... Case Western Reserve University

08/31/17 / #20170246456

Patterned stimulation intensity for neural stimulation

One aspect of the present disclosure relates to a system that can modulate the intensity of a neural stimulation signal over time. A pulse generator can be configured to generate a stimulation signal for application to neural tissue of an individual and modulate a parameter related to intensity of a pattern of pulses of the stimulation signal over time. ... Case Western Reserve University

08/31/17 / #20170245748

Device and method for determining the presence of middle ear fluid

A device for determining the presence of abnormal fluid in a middle ear of a subject includes an elongated probe, a first light source housed within the elongated probe, and a second light source housed within the elongated probe. The elongated probe includes a distal end for inspection of an ear. ... Case Western Reserve University

08/24/17 / #20170241990

Pericyte assay for transendothelial migration

A test animal for identifying blood vessel transendothelial migration-affecting factors or agents is described. The test animal comprises an implanted tissue mimicking model with a composite vascular structure comprising pericytes on test animal vasculature. ... Case Western Reserve University

08/24/17 / #20170239325

Autologous hiv-1 proteins for the treatment of latent hiv-1 infection

A method of reducing a latent hiv-specific memory-cd4+ t cell pool in a subject includes the steps of: preparing at least one hiv-1 protein coding sequence from a sample obtained from the subject, wherein the sample includes hiv-1 rna; introducing the at least one hiv-1 protein coding sequence into at least one expression construct using yeast homologous recombination; transfecting a cell with the at least one expression construct, wherein the hiv-1 protein is secreted by the cell and administering a therapeutically effective amount of the secreted hiv-1 protein and a pharmaceutically acceptable carrier to the subject, wherein the secreted hiv-1 protein stimulates latent hiv-specific memory-cd4+ t cells to induce latent hiv-1 replication resulting in hiv-specific memory-cd4+ t cell death in the subject.. . ... Case Western Reserve University

08/10/17 / #20170227495

Biochips to diagnose hemoglobin disorders and monitor blood cells

A biochip compatible with very small blood sample volumes is used for delecting for detecting hemoglobin disorders and monitoring disorders associated with aberrant blood cell deformability and adhesion, including disease severity, upcoming pain crisis, treatment response, and treatment effectiveness in a clinically meaningful way.. . ... Case Western Reserve University

08/10/17 / #20170224848

Targeting peptides and methods of use

A compound includes at least one targeting peptide coupled to a detectable moiety. The targeting peptide binds to edb-fn or eda-fn and includes at least one of amino acid sequence selected from the group consisting of seq id nos: 1-30.. ... Case Western Reserve University

08/10/17 / #20170224678

Inhibitors of bcl-2

Compounds and pharmaceutical compositions thereof for inducing apoptosis in a cell expressing bcl-2 and ip3r and their use in a method for treating neoplastic disorders in a subject.. . ... Case Western Reserve University

08/03/17 / #20170216438

Plant virus particles for delivery of photosensitive agents

Photodynamic virus particles including a plant virus particle associated with a photosensitizing agent are described. Methods of treating cancer in a subject by administering to the subject a therapeutically effective amount of the photodynamic virus particles and illuminating a cancer-bearing region of the subject to activate the photodynamic virus particles are also described.. ... Case Western Reserve University

08/03/17 / #20170216206

Multi-component nanochains

A multi-component nanochain for use in diagnostic and therapeutic applications includes at least three nanoparticles linked together to form the nanochain. At least one nanoparticle of the nanochain has an asymmetric surface chemistry defined by asymmetrically disposed first linkers and second linkers. ... Case Western Reserve University

07/27/17 / #20170209425

Methods and compositions for treating pathologies associated with bdnf signaling

A method of treating non-neurodegenerative pathologies associated with derangement in brain-derived neurotrophic factor signaling in the brain stem includes administering to the subject an amount of at least one ampakine effective to increase brain-derived neurotrophic factor nodose sensory neurons of the subject.. . ... Case Western Reserve University

07/27/17 / #20170209419

Methods of treating respiratory disorders

A method of treating a hyperoxia induced disease or disorder associated with gsno deficiency in a subject in need thereof includes administering to the subject a therapeutically effective amount of gsno or a gsno promoting agent.. . ... Case Western Reserve University

07/20/17 / #20170204470

Methods and compositions for detecting gastrointestinal and other cancers

This application describes methods and compositions for detecting and treating vimentin-associated neoplasia. Differential methylation of the vimentin nucleotide sequences has been observed in vimentin-associated neoplasia such as neoplasia of the upper or lower gastrointestinal tract, pancreas, and/or bladder.. ... Case Western Reserve University

07/13/17 / #20170196908

Compositions and methods of treating diabetic retinopathy

A method of treating diabetic retinopathy in a subject in need thereof includes administering to the subject a therapeutically effective amount of one or more agents that act as a trap of reactive aldehydes and/or inhibit diabetes-induced superoxide generation and capillary degeneration regulated by gpcr signaling pathways.. . ... Case Western Reserve University

07/06/17 / #20170193657

Prediction of recurrence of non-small cell lung cancer with tumor infiltrating lymphocyte (til) graphs

Methods and apparatus predict non-small cell lung cancer (nsclc) recurrence using radiomic features extracted from digitized hematoxylin and eosin (h&e) stained slides of a region of tissue demonstrating nsclc. One example apparatus includes an image acquisition circuit that acquires an image of a region of tissue demonstrating nsclc, a segmentation circuit that segments a cellular nucleus from the image, a feature extraction circuit that extracts a set of features from the image, a tumor infiltrating lymphocyte (til) identification circuit that classifies the segmented nucleus as a til or non-til, a graphing circuit that constructs a til graph and computes a set of til graph statistical features, and a classification circuit that computes a probability that the region will experience nsclc recurrence. ... Case Western Reserve University

07/06/17 / #20170193655

Radiomic features on diagnostic magnetic resonance enterography

Methods, apparatus, and other embodiments associated with predicting crohn's disease (cd) patient response to immunosuppressive (is) therapy using radiomic features extracted from diagnostic magnetic resonance enterography (mre). One example apparatus includes an image acquisition circuit that acquires an mre image of a region of tissue demonstrating cd pathology, a segmentation circuit that segments a region of interest (roi) from the diagnostic radiological image, a classification circuit that extracts a set of discriminative features from the roi and that distinguishes the roi as a responder or non-responder to is therapy, and a cd prediction circuit that generates a radiomic enterographic (ret) score based on the diagnostic radiological image or the set of discriminative features. ... Case Western Reserve University

07/06/17 / #20170193175

Prediction of recurrence of non-small cell lung cancer

Methods, apparatus, and other embodiments associated with predicting non-small cell lung cancer (nsclc) patient response to adjuvant chemotherapy therapy using radiomic features extracted from digitized hematoxylin and eosin (h&e) stained slides of a region of tissue demonstrating nsclc. One example apparatus includes an image acquisition circuit that acquires an h&e image of a region of tissue demonstrating nsclc pathology, a segmentation circuit that segments a region of interest (roi) from the diagnostic radiological image, a feature extraction that extracts a set of discriminative features from the roi, and a classification circuit that generates a probability that the roi will experience nsclc recurrence. ... Case Western Reserve University

07/06/17 / #20170192006

Biomarkers for human monocyte myeloid0derived suppresor cells

A method for diagnosing an increased risk of a cancer in a subject includes the steps of obtaining a blood sample from the subject and determining, in the blood sample, a level of two or more of the polypeptides selected from the group consisting of vnn2, kcnj15, serpinb2, creb5, icam3, nfe2, mnda, pxn, fcar, tshz3, nrg1, alox5ap, pad14, pad12, qpc, vnn1, serpinb10, clec4d, trem1, clec4e, cd82, mgam, tmem45b and vnn3, wherein an increase in the level of two or more of the polypeptides compared to a control level is indicative of an increased risk of cancer in the subject.. . ... Case Western Reserve University

07/06/17 / #20170191942

Systems and methods for detecting an optical change indicating the presence of an analyte

One aspect of the present disclosure relates to an analyte sensor device. The analyte sensor device can include an optode layer that undergoes an optical change in the presence of an analyte. ... Case Western Reserve University

07/06/17 / #20170189366

Method for treating disorders related to complement activation

A method for treating or preventing a complement activated t-cell mediated disorder in a subject includes administering a therapeutically effective amount of a pharmaceutical composition to the subject. The pharmaceutical composition includes at least one amidine compound or pharmaceutically acceptable salt.. ... Case Western Reserve University

06/29/17 / #20170185730

Machine learning approach to selecting candidates

Example apparatus and methods concern a clinical decision support system for the selection of candidates. A clinical decision support system includes a candidate data logic that receives electronic data that identifies candidate data, including symptom and non-symptom data, for a candidate. ... Case Western Reserve University

06/29/17 / #20170184564

Sensor for nitric oxide detection

A sensor for detecting nitric oxide includes a substrate, a working electrode formed on a surface of the substrate, a counter electrode formed on the surface of the substrate, a dielectric layer covering a portion of the working electrode and counter electrode and defining an aperture exposing other portions of the working electrode and counter electrode, a polyelectrolyte film covering the exposed other portions working electrode and counter electrode, the polyelectrolyte film including at least one metalloporphyrins compound or metallophthalocyanine compound capable of increasing the rate of electrochemical oxidation-reduction reaction with nitric oxide and providing the detection of nitric oxide at a lower oxidation potential.. . ... Case Western Reserve University

06/29/17 / #20170182312

Neural electrodes and methods for implanting same

One aspect of the present disclosure can include a method for implanting a neural electrode in a fascicle including a target nerve. One step of the method can include inserting a microwire assembly into the fascicle. ... Case Western Reserve University

06/29/17 / #20170181652

System and method for mapping activity in peripheral nerves

Systems and methods are provided for controlling an entity in response to activity in a peripheral nerve comprising a plurality of fascicles. A multicontact electrode assembly is configured to record activity from the peripheral nerve. ... Case Western Reserve University

06/22/17 / #20170176470

Detection of carboxyalkylpyrrole or pentylpyrrole ethanolamine phospholipids

A method of detecting carboxyalkylpyrrole ethanolamine phospholipids (cap-eps) or pentylpyrrole ethanolamine phospholipids (cap-eps) in a bodily sample from a subject includes obtaining a bodily sample from a subject suspected of including carboxyalkylpyrrole ethanolamine phospholipids (cap-eps) or pentylpyrrole ethanolamine phospholipids (pp-eps) extracting carboxyalkylpyrrole ethanolamine phospholipids or pentylpyrrole ethanolamine phospholipids from the bodily sample; hydrolyzing carboxyalkylpyrrole or pentylpyrrole ethanolamine phospholipids from the extracted with a phospholipase d to form carboxyalkylpyrrole ethanolamine (cap-etn) and pentylpyrrole ethanolamine (pp-etn) derivatives; and determining the amount of carboxyalkylpyrrole ethanolamine (cap-etn) and pentylpyrrole ethanolamine (pp-etn) by mass spectrometry.. . ... Case Western Reserve University

06/22/17 / #20170176469

Molecular probes for detecting lipids

A method of detecting aberrant lipid accumulation in a subject includes administering to the subject a molecular probe that includes a fluorescent trans stilbene derivative or stilbenzene derivative and detecting the amount or distribution of the molecular probe in a tissue of interest of the subject.. . ... Case Western Reserve University

06/22/17 / #20170174862

Elastomeric and viscoelastic materials formed from poly(acrylic acid) gels

Disclosed herein are novel materials and methods of forming those novel materials. The materials are synthesized from poly(acrylic acid), a crosslinker; and a salt. ... Case Western Reserve University

06/15/17 / #20170169566

Automated analysis of intravascular oct image volumes

This disclosure provides systems and methods to automatically classify stent struts as covered or uncovered and to measure the thickness of tissue coverage. As one example, the method includes storing three-dimensional image data acquired intravascularly via an optical coherence tomography (oct) apparatus and detecting struts based on analysis of the image data. ... Case Western Reserve University

06/15/17 / #20170166720

Tannin-modified porous material and methods of making same

The present disclosure provides an aerogel formed of a tannin-containing porous material including a polymeric material, a tannin, and a clay. In some embodiments, the tannin-containing porous material is produced by forming an aerogel precursor including a polymeric material, a tannin, and a liquid dispersion medium; freezing the aerogel precursor; and freeze drying. ... Case Western Reserve University

06/15/17 / #20170165489

Load-preserving method for defining anisotropy in volume-conductor models

Example systems and methods concern systems and methods for modeling conduction in a volume. In one embodiment, diffusion eigenvalues of a plurality of diffusion tensors are received. ... Case Western Reserve University

06/15/17 / #20170165322

Peptide and small molecule agonists of epha and their uses in disease

A method of treating a neoplastic disorder in a subject includes administering to a eph kinase expressing neoplastic cell of the subject being treated an epha agonist and at least one immunosuppressant.. . ... Case Western Reserve University

06/08/17 / #20170161891

Scaling up convolutional networks

Methods, apparatus, and other embodiments associated with classifying a region of tissue represented in a digitized whole slide image (wsi) using iterative gradient-based quasi-monte carlo (qmc) sampling. One example apparatus includes an image acquisition circuit that acquires a wsi of a region of tissue demonstrating cancerous pathology, an adaptive sampling circuit that selects a subset of tiles from the wsi using an iterative qmc sobol sequence sampling approach, an invasiveness circuit that determines a probability of a presence of invasive pathology in a member of the subset of tiles, a probability map circuit that generates an invasiveness probability map based on the probability, a probability gradient circuit that generates a gradient image based on the invasiveness probability map, and a classification circuit that classifies the region of tissue based on the probability map. ... Case Western Reserve University

06/08/17 / #20170157073

Peptide and small molecule agonists of epha and uses thereof

Methods and compositions for activating an epha receptor can be used for identifying therapeutic agents for cancer.. . ... Case Western Reserve University

05/18/17 / #20170137488

Long-acting single-chain insulin analogues

A single-chain insulin analogue containing a basic side chain at position a8 (arginine, histidine, lysine, or ornithine), a basic side chain at position b29 (arginine, histidine, lysine, or ornithine), and a foreshortened c-domain of length 6-11 residues is provided. Residues c1 and c2 of the c-domain have a net negative charge of −1 or −2; c3 is chosen from a group consisting of gly, ala, pro, or ser; and the remaining c-domain segment is successively derived from the c-domain of igf-ii (rrsr, srrsr, vsrrsr, rvsrrsr, or srvsrrsr; seq id no: 13). ... Case Western Reserve University

05/18/17 / #20170136242

Systems and methods for closed loop control to ensure a constant current output with a changing load resistance

A closed loop control system automatically ensures that an output of a device is constant. The system can receive an input to set a fixed value for a variable (e.g., a current, a heart rate, a tissue perfusion, an ion level, etc.), and this variable can be delivered to a feedback component. ... Case Western Reserve University

04/27/17 / #20170115274

Multicellular system and method for multiparametric analysis

A system for multiparametric analysis includes a substrate and a three-dimensional (3d) cell aggregate. The substrate has a major surface and includes at least one radial electrode array. ... Case Western Reserve University

04/27/17 / #20170114395

Clostridium difficile culture medium

A culture medium for culturing clostridium difficile under aerobic culture conditions, the medium includes a nutrient medium that promotes growth of clostridium difficile and amounts of thioglycolic and l-cystine effective to consume oxygen in the culture medium and facilitate growth of clostridium difficile.. . ... Case Western Reserve University

04/27/17 / #20170112892

Retinylamine derivitives for treatment of ocular disorders

A pharmaceutical composition includes a retinylamine derivative having the following formula (i): where r1 is an amino acid residue, a dipeptide or a tripeptide that is linked to the retinylamine by an amide bond.. . ... Case Western Reserve University

04/27/17 / #20170112408

Systems and methods for at home neural recording

One aspect of the present disclosure relates to a system to facilitate at home neural monitoring. The system can include a wearable device and an external device. ... Case Western Reserve University

04/20/17 / #20170106098

Targeting cancer cells and tissue using filamentous plant virus particles

A filamentous plant virus carrier comprising a filamentous plant virus particle that has been modified to carry an imaging agent or cytotoxic compound is described. The filamentous plant virus carrier can be used in a method of targeting cancer cells and tissue by administering it to a subject. ... Case Western Reserve University

04/13/17 / #20170102350

Electrochemical sensor for analyte detection

A sensor for the detection of an analyte in a biological sample includes a substrate, a working electrode and counter electrode formed on a surface of the substrate, and a receptor functionalized or chemically functionalized to a surface of an exposed portion of the working electrode. The receptor can selectively bind to the analyte of interest and the analyte once bound is detectable by measuring the current flow between the working electrode and counter electrode.. ... Case Western Reserve University

04/13/17 / #20170101662

System and method for detecting neural injury

A detection system for determining pyruvate dehydrogenase (pdh) levels in a bodily sample includes at least one reaction solution for generating nad+ upon combination with pdh in the bodily sample, the reaction solution including pyruvate and nadh and a biosensor for determining the level of generated nad+.. . ... Case Western Reserve University

04/13/17 / #20170101456

Non-standard insulin analogues

An insulin analogue comprises a b-chain polypeptide containing a cyclohexanylalanine substitution at position b24 and optionally containing additional amino-acid substitutions at positions a8, b28, and/or b29. A proinsulin analogue or single-chain insulin analogue containing a b domain containing a cyclohexanylalanine substitution at position b24 and optionally containing additional amino-acid substitutions at positions a8, b28, and/or b29. ... Case Western Reserve University

04/13/17 / #20170100591

Methods and associated neural prosthetic devices for bridging brain areas to improve function

Methods for bridging brain sites between which there is substantially no effective communication, and associated neural prosthetic devices, are provided. A neural spike in a first neural site in a subject is detected, and a stimulus to a second neural site in the subject is delivered within a defined period of time after the detection of the neural spike, wherein there is substantially no effective communication between the first and second neural sites. ... Case Western Reserve University

04/13/17 / #20170100587

Neural prosthesis system and method of control

Multiple designs, systems, methods and processes for control using electrical signals recorded from clinically paralyzed muscles and nerves are presented. The discomplete neural prosthesis system and method for clinically paralyzed humans utilizes a controller. ... Case Western Reserve University

04/06/17 / #20170095663

Systems and methods that provide electrical stimulation to a nerve to reduce a reflex that affects a bodily function

One aspect of the present disclosure relates to a system for electrical stimulation. A waveform generator can be configured to generate an electrical waveform. ... Case Western Reserve University

03/23/17 / #20170081767

Alloy surface activation by immersion in aqueous acid solution

A process for surface activation or depassivation of an article, in particular an alloy, by immersion of the alloy in an aqueous acid solution. The surface activation methods of the present invention can be performed during a relatively short period of time and achieve reductions in production costs and provide environmental friendliness as compared to prior art processes. ... Case Western Reserve University

03/23/17 / #20170080244

Systems and methods for fast and reversible nerve block

One aspect of the present disclosure relates a system that can quickly and reversibly block conduction in a nerve. The system can include a first nerve block modality that provides heat to the nerve to block conduction in the nerve. ... Case Western Reserve University

03/16/17 / #20170072026

Compositions and methods of treating root avulsion injury

A method of treating root avulsion injury in a subject in need thereof includes administering to the subject a therapeutic agent that inhibits one or more of catalytic activity, signaling, and function of ptpσ.. . ... Case Western Reserve University

03/16/17 / #20170071965

Antimetabolite agent combinations in the treatment of cancer

A method treating cancer in a subject comprises administering to the subject a therapeutically effective amount of an antimetabolite agent that induces formation of ap sites in cancer cells of the subjects and an amount ap endonuclease inhibitor effective to potentiate the cytotoxicity of the antimetabolite agent to the cancer cells.. . ... Case Western Reserve University

03/09/17 / #20170065626

Compositions and methods of treating of bacterial infections with beta-lactamase inhibitors

A method of treating a bacterial infection in a subject in need thereof includes administering to the subject therapeutically effective amounts of at least one β-lactam antibiotic and at least one triazolylmethyl boronic acid.. . ... Case Western Reserve University

03/02/17 / #20170056544

Polymer nanofiber scaffolds and uses thereof

A polymer nanofiber scaffold includes a plurality of melt extruded nanofibers that are chemically modified to append surface functionality to the nanofibers.. . ... Case Western Reserve University

02/23/17 / #20170053090

Treatment planning and evaluation for rectal cancer via image analytics

Methods and apparatus associated with predicting colorectal cancer tumor invasiveness are described. One example apparatus includes a set of circuits, and a data store that stores radiological images of tissue demonstrating colorectal cancer. ... Case Western Reserve University

02/23/17 / #20170051070

Method for treating cd40-mediated diseases

A cell-permeable polypeptide includes a membrane transduction domain and a polypeptide comprising an amino acid sequence substantially homologous to the amino acid sequence of the traf2,3 binding domain, the cell permeable peptide inhibiting binding of traf2 to the traf2,3 binding domain of cd40 to decrease or inhibit a cd-40 activity or signal transduction pathway associated with a cd40-mediated disease in cells of a subject.. . ... Case Western Reserve University

02/23/17 / #20170050364

Fiber reinforced hydrogels and methods of making same

Disclosed herein are biomaterials that include a plurality of fibers embedded in a matrix of hydrogel material. The plurality of fibers and hydrogel material are formed during one process step. ... Case Western Reserve University

02/23/17 / #20170050024

Treatment of pain using electrical nerve conduction block

Described herein are systems and methods for the treatment of pain using electrical nerve conduction block (encb). Contrary to other methods of pain treatment, the encb can establish a direct block of neural activity, thereby eliminating the pain. ... Case Western Reserve University

02/16/17 / #20170043520

Methods for layer multiplication co-extrusion of high viscous polymeric material systems

Methods for co-extruding multiple layers of materials, in particular high viscosity elastomer materials, wherein the method allows the use of either rheologically matched or unmatched elastomers. Devices for practicing the methods are disclosed. ... Case Western Reserve University

02/16/17 / #20170043051

Dry spray on hemostatic system

The invention provides for dry spray compositions comprising co-polymers comprising a core, water-soluble polymer and a peptide.. . ... Case Western Reserve University

02/09/17 / #20170039737

Decision support for disease characterization and treatment response with disease and peri-disease radiomics

Methods, apparatus, and other embodiments associated with classifying a region of tissue using textural analysis are described. One example apparatus includes an image acquisition logic that acquires an image of a region of tissue demonstrating cancerous pathology, a delineation logic that distinguishes nodule tissue within the image from the background of the image, a perinodular zone logic that defines a perinodular zone based on the nodule, a feature extraction logic that extracts a set of features from the image, a probability logic that computes a probability that the nodule is benign or that the nodule will respond to a treatment, and a classification logic that classifies the nodule tissue based, at least in part, on the set of features or the probability. ... Case Western Reserve University

02/09/17 / #20170036018

Hybrid method for modulating upper airway function in a subject

A hybrid method is provided for modulating upper airway function in a subject. The method includes applying first and second therapy signals to the subject to modulate at least one extrinsic laryngeal muscle and at least one intrinsic laryngeal muscle to synergistically control laryngeal motion and vocal fold movement, respectively.. ... Case Western Reserve University

02/09/17 / #20170035381

Characterizing disease and treatment response with quantitative vessel tortuosity radiomics

Methods, apparatus, and other embodiments associated with classifying a region of tissue using quantified vessel tortuosity are described. One example apparatus includes an image acquisition logic that acquires an image of a region of tissue demonstrating cancerous pathology, a delineation logic that distinguishes nodule tissue within the image from the background of the image, a perinodular zone logic that defines a perinodular zone based on the nodule, a feature extraction logic that extracts a set of features from the image including a set of tortuosity features, a probability logic that computes a probability that the nodule is benign, and a classification logic that classifies the nodule tissue based, at least in part, on the set of features or the probability. ... Case Western Reserve University

02/02/17 / #20170028210

Delaying the onset of muscle fatigue associated with functional electrical stimulation

The present invention relates a system that can configure a stimulus for functional electrical stimulation (“fes”) to maintain a constant muscle force while delaying the onset of muscle fatigue and a related method of use. The stimulus can be delivered to a nerve via a set of multiple electrode contacts according to a stimulation parameter that maximizes a joint moment associated with the stimulus and minimizes the overlap between pairs of contacts. ... Case Western Reserve University

02/02/17 / #20170027861

Method of treating t cell mediated disorders

A method of treating a t-cell mediated disorders in a tissue includes administering to the tissue of the subject a therapeutically effective amount of a complement antagonist that substantially reduces t-cell differentiation or t-cell inflammatory cytokine generation.. . ... Case Western Reserve University

02/02/17 / #20170027446

Intra-operative molecular imaging

A system for detecting tumor margins includes a topical protease-specific, fluorescence imaging probe that is activatable by enzymatic activation to produce a visually differentiated signal upon topical application to a targeted cancer cell that secretes an enzyme that activates the protease-specific, fluorescence imaging probe, means for topically administering the imaging probe to the cancer cell; and an imaging device to detect activation of the imaging probe administered to the cancer cell.. . ... Case Western Reserve University

01/26/17 / #20170021003

Vaccination using plant virus particles linked to her2 antigens

A vaccine composition including a plant virus particle linked to an her2 antigen is described. The vaccine composition can be used for methods of treating or preventing an her2-expressing cancer in a subject by administering to a subject in need thereof an effective amount of the vaccine composition.. ... Case Western Reserve University

01/19/17 / #20170018198

Automated assessment of cognitive, fine-motor, and memory skills

An automated assessment of various capabilities, such as cognitive, fine-motor, and memory skills, includes the use of tangible geometric games (tag-games), which are a play-based assessment tools. Tag-games are based on sensor-integrated geometric blocks (sig-blocks) and an interactive graphical user interface (gui), which provide a means for real-time and remote monitoring of a user through operative communication between blocks and a remote computer. ... Case Western Reserve University

01/19/17 / #20170014626

Stimulation of the forno-dorso-commissure (fdc) for seizure suppression and memory improvement

Example apparatus and methods cause activation of target neural tissue through electrical stimulation of a connected white matter tract to reduce the hyper-excitability of the target neural tissue and thus reduce seizures while preserving memory in humans. Example apparatus and methods apply low frequency (e.g., <10 hz) electrical stimulation to the forno-dorso-commissure (fdc), detect an electrical signal generated in an area connected to, innervated by, or that can be activated by the fdc in response to the stimulation, and reconfigure the stimulation based on the detected signal and a desired therapeutic effect. ... Case Western Reserve University

01/19/17 / #20170014451

Compositions and methods of treating t cell mediated disorder

A method of generating a cd4+foxp3+ treg cell, the method includes administering at least one complement antagonist to a naive cd4+ t cell at an amount effective to substantially inhibits c3a receptor (c3ar) and/or c5a receptor (c5ar) signal transduction in the cd4+ t cell, induce tgf-β1 expression of the cd4+ t cell, and induce differentiation of the of the naive cd4+ t cell into a cd4+foxp3+ treg cell.. . ... Case Western Reserve University

01/05/17 / #20170000774

Myeloid differentiation inducing agents

Myeloid differentiating agents can be used in the treatment of myeloid proliferative disorders.. . ... Case Western Reserve University








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