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Case Western Reserve University patents


Recent patent applications related to Case Western Reserve University. Case Western Reserve University is listed as an Agent/Assignee. Note: Case Western Reserve University may have other listings under different names/spellings. We're not affiliated with Case Western Reserve University, we're just tracking patents.

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Dual energy x-ray coronary calcium grading

Methods and apparatus for grading coronary calcium, including an example apparatus that includes a set of logics and a memory that stores a set of radiographic images. The set of logics includes an image acquisition logic that acquires a set of radiographic images of a region of tissue, the set... Case Western Reserve University

Multilayer cellular membranes for filtration applications

A filter includes a fibrous substrate having a plurality of coextruded first polymer material fibers and second polymer material fibers. Each of the first and second fibers are separated from each other and have a rectangular cross-section defined in part by an additional encapsulating polymer material that is separated from... Case Western Reserve University

Low frequency non-invasive sensorial stimulation for seizure control

Example apparatus and methods reduce epileptic seizures in a human patient by non-invasively providing low frequency (e.g., 1-10 Hz) audio stimuli coordinated with low frequency (e.g., 1-10 Hz) visual stimuli to the patient. The signals are provided non-invasively through the eyes and ears. The audio stimuli and visual stimuli may... Case Western Reserve University

Methods of detecting cancer

A method of detecting the presence of glioblastomas and/or recurrent glioblastomas in a subject in need thereof includes isolating CD14+ cells from a blood sample of the subject and determining the ratio of isolated CD14+ cells expressing low levels of HLA-DR to isolated CD14+ cells expressing VNN2, wherein the subject... Case Western Reserve University

Entropy-based radiogenomic descriptors on magnetic resonance imaging (mri) for molecular characterization of breast cancer

Methods, apparatus, and other embodiments distinguish disease phenotypes and mutational status using co-occurrence of local anisotropic gradient orientations (CoLIAGe) and Laws features. One example apparatus includes a set of circuits that acquires a radiologic image (e.g., MRI image) of a region of tissue demonstrating breast cancer, computes a gradient orientation... Case Western Reserve University

Thermoelectric energy harvesting from pavement structure

Electrically parallel thermoelectric modules (TEMs), especially induced multilayered TEMs, have the potential to stimulate the applications of TEMs to harvest energy from naturally existing temperature gradients, because of the convenience and cost-effectiveness to fabricate large area devices. A thermoelectric-based system comprises a thermoelectric module comprising an upper surface and a... Case Western Reserve University

Anti-virulence compositions and methods

A method of treating a bacterial infection in a subject in need thereof includes administering to the subject an AgrA antagonist.... Case Western Reserve University

Quantifying mass effect deformation with structural radiomics in brain tumor patients

Methods and apparatus quantify mass effect deformation in diagnostic images of patients demonstrating glioblastoma multiforme (GBM). One example apparatus includes an image acquisition circuit that acquires an image of a region of tissue demonstrating GBM pathology, a delineation circuit that segments a tumor region from the image, a pre-processing circuit... Case Western Reserve University

Multi-pass adaptive voting for nuclei detection in histopathological images

Methods, apparatus, and other embodiments detect nuclei in histopathological images. One example method includes accessing a histopathology image that includes a plurality of pixels, generating a gradient field map based on the histopathology image, generating a refined gradient field map based on the gradient field map, calculating a voting map... Case Western Reserve University

System and ensuring airway patency when asleep

One aspect of the present disclosure relates to a system that provides an alternative to traditional treatments for sleep apnea. The system allows to apply an electrical stimulus through an electrode to stimulate an afferent nerve fiber while a patient is sleeping. The system also includes activating an endogenous central... Case Western Reserve University

Compositions and methods for the treatment of pervasive development disorders

A method of treating a pervasive development disorder in a subject includes administering to the subject a therapeutically effective amount of an NMDAR antagonist, with an intermittent dosing regimen.... Case Western Reserve University

Disease characterization from fused pathology and radiology data

Methods and apparatus distinguish invasive adenocarcinoma (IA) from in situ adenocarcinoma (AIS). One example apparatus includes a set of circuits, and a data store that stores three dimensional (3D) radiological images of tissue demonstrating IA or AIS. The set of circuits includes a classification circuit that generates an invasiveness classification... Case Western Reserve University

Compositions and methods for stimulating ventilatory and/or respiratory drive

A method of stimulating ventilatory and/or respiratory drive in a subject in need thereof includes administering to the subject a therapeutically effective amount of a composition comprising a cystine ester or a pharmaceutically acceptable salt thereof. Embodiments described herein relate to compositions and methods of stimulating ventilatory and/or respiratory drive... Case Western Reserve University

Ketyl radical induced photoreduction of graphene oxide; grafting of metal nanoparticles on graphene by photoreduction

Photoreduction of graphene oxide, by UV-generated ketyl radicals, to graphene. The photoreduction is versatile and can be carried out in solution, solid-state, and even in polymer composites. Reduction of graphene oxide can take place in various polymer matrixes. Methods for producing graphene-supported metal nanoparticles by photoreduction. Graphene oxide and a... Case Western Reserve University

Insulin analogues with selective signaling properties and reduced mitogenicity

A two-chain insulin analogue contains Aspartic Acid at position B10 and penta-fluoro-Phenylalanine at position B24, optionally Histidine or Glutamic Acid at position A8, optionally additional substitutions or modifications at positions A13 and/or A14 and/or B28 and/or B29. The analogue may be an analogue of a mammalian insulin, such as human... Case Western Reserve University

Methods and compositions for detecting colorectal neoplasias

The disclosure provides methods for identifying genomic loci that are differentially methylated in colorectal neoplasias. Identification of methylated genomic loci has numerous uses, including for example, to characterize disease risk, to predict responsiveness to therapy, to non-invasively diagnose subjects and to treat subjects determined to have colorectal neoplasias.... Case Western Reserve University

Systems and methods for translation of medical imaging using machine learning

A medical image (24) with contrast of one imaging modality is emulated from images with other contrast characteristics. A plurality of input images (20) of a region of interest with the other contrast characteristics is received. A transform (22) which was generated by machine learning is applied to the corresponding... Case Western Reserve University

Compositions and methods of modulating s-nitrosylation

A method of treating disorders associated with NO/SNO deficiency or benefiting from increased SNO in a subject in need thereof includes administering to the subject an ADH inhibitor, AKR inhibitor, SNO-CoAR inhibitor, and/or SNO-CoA at an amount(s) effective to promote S-nitrosylation of proteins in the subject.... Case Western Reserve University

Long-acting insulin analogue preparations in insoluble and crystalline forms

A pharmaceutical formulation comprises an insulin analogue or a physiologically acceptable salt thereof, wherein the insulin analogue or a physiologically acceptable salt thereof contains an insulin A-chain sequence that contains paired Histidine substitutions at A4 and A8, and optionally a substitution at A21. The formulation further contains a pharmaceutically acceptable... Case Western Reserve University

Predicting response to pemetrexed chemotherapy in non-small cell lung cancer (nsclc) with baseline computed tomography (ct) shape and texture features

Methods, apparatus, and other embodiments predict response to pemetrexed based chemotherapy. One example apparatus includes an image acquisition circuit that acquires a radiological image of a region of tissue demonstrating NSCLC that includes a region of interest (ROI) defining a tumoral volume, a peritumoral volume definition circuit that defines a... Case Western Reserve University

Computerized analysis of computed tomography (ct) imagery to quantify tumor infiltrating lymphocytes (tils) in non-small cell lung cancer (nsclc)

Methods, apparatus, and other embodiments predict tumor infiltrating lymphocyte (TIL) density from pre-surgical computed tomography images of a region of tissue demonstrating non-small cell lung cancer (NSCLC). One example apparatus includes a set of circuits that includes an image acquisition circuit that accesses a radiological image of a region of... Case Western Reserve University

Compounds and methods of treating ocular disorders

A method of treating an ocular disorder in a subject associated with increased all-trans-retinal in an ocular tissue includes administering to the subject a therapeutically effective amount of a primary amine compound of formula (I); and pharmaceutically acceptable salts thereof.... Case Western Reserve University

Multichannel ultra-low noise amplifier

The present disclose generally relates to a multichannel low-noise amplifier. At each input to the multichannel low-noise amplifiers, a plurality of transistors can be connected in parallel. This parallel connection decreases the voltage noise beyond what is possible using a single input transistor at each input. As an additional benefit,... Case Western Reserve University

Tubular, equipment and forming the same

A tubular including a plurality of first-type layers; and a plurality of second-type layers each disposed between a pair of adjacent first-type layers, wherein the plurality of first-type layers includes at least two first-type layers, wherein the plurality of second-type layers includes at least two second-type layers, and wherein a... Case Western Reserve University

System and spectroscopic magnetic resonance fingerprinting

The present disclosure relates to a method for performing phosphorous-31 spectroscopic magnetic resonance fingerprinting (MRF). The method comprises performing a pulse sequence using a series of varied sequence blocks to a volume in a subject where the volume contains phosphate metabolites. A series of signal evolutions are acquired from the... Case Western Reserve University

Halogenated insulin analogues of enhanced biological potency

An insulin molecule comprises an Asp substitution at position B10, Glu at one or more of positions corresponding to A8, B28, and B29, and a halogenated phenylalanine at position B24. The analogue may optionally include (i) N-terminal deletion of one, two or three residues from the B chain, (ii) a... Case Western Reserve University

Automated intravascular plaque classification

Methods and apparatus automatically classify intravascular plaque using features extracted from intravascular optical coherence tomography (IVOCT) imagery. One example apparatus includes an image acquisition circuit that accesses a set of IVOCT images, a pre-processing circuit that generates a blood vessel mask based on the IVOCT images, a feature extraction circuit... Case Western Reserve University

Compositions and methods for treating lung remodeling diseases

In one aspect, the present disclosure can relate to a method for treating a lung remodeling disease in a subject. One step of the method can include assaying one or more mesenchymal stem cells (MSCs) for one or more of the following effects: (1) reduce collagen deposition in the lungs... Case Western Reserve University

System and detecting of alpha-methylacyl-coa racemase (amacr) and prostate cancer

A detection system for determining alpha-methylacyl-CoA (AMACR) levels in a bodily sample includes at least one reaction solution for generating H2O2 upon combination with AMACR in the bodily sample and a biosensor for determining a level of generated H2O2. The reaction solution includes a (2R)-2-methylacyl-CoA epimer that can be chirally... Case Western Reserve University

System and improved rf system performance in mri systems

An apparatus, a system, and a chip are provided for improving RF system performance in MRI systems. The apparatus includes a radio-frequency (RF) coil array disposed at least partially in a coil housing, where the RF coil array may include at least one coil configured to receive magnetic resonance (MR)... Case Western Reserve University

Nerve cuff for implantable electrode

A system for functional electrical stimulation can include a cuff and a stimulation device. The cuff can be attachable to a nerve or a muscle filament. The cuff can include an elastic collar configured to exert a force on the nerve or the muscle filament to reshape the nerve or... Case Western Reserve University

Multilayer polymer dielectric film

A multilayer polymer dielectric film includes a stack of coextruded, alternating first dielectric layers and second dielectric layers that receive electrical charge. The first dielectric layers include a first polymer material and the second dielectric layers include a second polymer material different from the first polymer material. The first polymer... Case Western Reserve University

Sporicidal composition

A sporicidal composition includes an acidified short or medium chain, linear or branched alcohol having a pH effective to promote killing of spore forming bacteria and bacterial spores.... Case Western Reserve University

Fitting modular pressure relief cushion

A high-performance, low-cost modular cushion using range of novel dynamically responsive materials has been designed and developed for use in seating pressure relief. The use of individual contained spheres creates a localized area of gel to minimize both flattening under pressure, and inflating in areas without contact while the elastic... Case Western Reserve University

Diagnostic and therapeutic targeting of dnmt-1 associated rna in human cancer

A method for treating cancer in a subject in need thereof includes administering to cancer cells of the subject an agent effective to modulate the level of DNMT1-associated RNA and/or the interaction of DNMT1-associated RNA and DNMT1 in the cancer cells of the subject. Embodiments described herein relate to RNAs... Case Western Reserve University

09/14/17 / #20170260341

Cationic ultraviolet curing of resins with onium salt

Disclosed herein is a method of forming a photocurable polymer system. The method includes providing a polymer, providing a diaryl iodonium salt, blending said polymer and diaryl iodonium salt, applying the blend to a substrate; and crosslinking the blend. The polymer can be a silicone-based polymer, such as PDMS-ECHE. The... Case Western Reserve University

09/07/17 / #20170252326

Compositions and methods of inhibiting metallo-beta-lactamases

A method of treating a bacterial infection in a subject in need thereof includes administering to the subject therapeutically effective amounts of at least one β-lactam antibiotic and at least one bisthiazolidine metallo-β-lactamase inhibitor.... Case Western Reserve University

08/31/17 / #20170245748

Device and determining the presence of middle ear fluid

A device for determining the presence of abnormal fluid in a middle ear of a subject includes an elongated probe, a first light source housed within the elongated probe, and a second light source housed within the elongated probe. The elongated probe includes a distal end for inspection of an... Case Western Reserve University

08/31/17 / #20170246456

Patterned stimulation intensity for neural stimulation

One aspect of the present disclosure relates to a system that can modulate the intensity of a neural stimulation signal over time. A pulse generator can be configured to generate a stimulation signal for application to neural tissue of an individual and modulate a parameter related to intensity of a... Case Western Reserve University

08/31/17 / #20170247801

Bromide removal from aqueous solutions

Systems and processes for removing and purifying bromide from an aqueous bromide solution are described. Electrochemistry is used to either convert bromide to bromine to allow its extraction in an organic phase, or to cause deposition of bromine onto an electrode. In either case, once removed from the aqueous bromide... Case Western Reserve University

08/31/17 / #20170248541

Sensor for volatile organic compound detection

A sensor for detecting volatile organic compounds (VOCs) includes a substrate, a working electrode formed on a surface of the substrate, a counter electrode formed on the surface of the substrate, a dielectric layer covering a portion of the working electrode and counter electrode and defining an aperture exposing other... Case Western Reserve University

08/24/17 / #20170239325

Autologous hiv-1 proteins for the treatment of latent hiv-1 infection

A method of reducing a latent HIV-specific memory-CD4+ T cell pool in a subject includes the steps of: preparing at least one HIV-1 protein coding sequence from a sample obtained from the subject, wherein the sample includes HIV-1 RNA; introducing the at least one HIV-1 protein coding sequence into at... Case Western Reserve University

08/24/17 / #20170241990

Pericyte assay for transendothelial migration

A test animal for identifying blood vessel transendothelial migration-affecting factors or agents is described. The test animal comprises an implanted tissue mimicking model with a composite vascular structure comprising pericytes on test animal vasculature. The test animal can be used in a method of identifying or evaluating a blood vessel... Case Western Reserve University

08/10/17 / #20170224678

Inhibitors of bcl-2

Compounds and pharmaceutical compositions thereof for inducing apoptosis in a cell expressing Bcl-2 and IP3R and their use in a method for treating neoplastic disorders in a subject.... Case Western Reserve University

08/10/17 / #20170224848

Targeting peptides and methods of use

A compound includes at least one targeting peptide coupled to a detectable moiety. The targeting peptide binds to EDB-FN or EDA-FN and includes at least one of amino acid sequence selected from the group consisting of SEQ ID NOs: 1-30.... Case Western Reserve University

08/10/17 / #20170227495

Biochips to diagnose hemoglobin disorders and monitor blood cells

A biochip compatible with very small blood sample volumes is used for delecting for detecting hemoglobin disorders and monitoring disorders associated with aberrant blood cell deformability and adhesion, including disease severity, upcoming pain crisis, treatment response, and treatment effectiveness in a clinically meaningful way.... Case Western Reserve University

08/03/17 / #20170216206

Multi-component nanochains

A multi-component nanochain for use in diagnostic and therapeutic applications includes at least three nanoparticles linked together to form the nanochain. At least one nanoparticle of the nanochain has an asymmetric surface chemistry defined by asymmetrically disposed first linkers and second linkers. The nanoparticles are linked to form the nanochain... Case Western Reserve University

08/03/17 / #20170216265

Inhibitors of short-chain dehydrogenase activity for modulating hematopoietic stem cells and hematopoiesis

A method of modulating hematopoietic stem cells and hematopoiesis includes administering to a subject in need thereof a 15-PGDH inhibitor.... Case Western Reserve University

08/03/17 / #20170216438

Plant virus particles for delivery of photosensitive agents

Photodynamic virus particles including a plant virus particle associated with a photosensitizing agent are described. Methods of treating cancer in a subject by administering to the subject a therapeutically effective amount of the photodynamic virus particles and illuminating a cancer-bearing region of the subject to activate the photodynamic virus particles... Case Western Reserve University

07/27/17 / #20170209419

Methods of treating respiratory disorders

A method of treating a hyperoxia induced disease or disorder associated with GSNO deficiency in a subject in need thereof includes administering to the subject a therapeutically effective amount of GSNO or a GSNO promoting agent.... Case Western Reserve University

07/27/17 / #20170209425

Methods and compositions for treating pathologies associated with bdnf signaling

A method of treating non-neurodegenerative pathologies associated with derangement in brain-derived neurotrophic factor signaling in the brain stem includes administering to the subject an amount of at least one ampakine effective to increase brain-derived neurotrophic factor nodose sensory neurons of the subject.... Case Western Reserve University

07/20/17 / #20170204470

Methods and compositions for detecting gastrointestinal and other cancers

This application describes methods and compositions for detecting and treating vimentin-associated neoplasia. Differential methylation of the vimentin nucleotide sequences has been observed in vimentin-associated neoplasia such as neoplasia of the upper or lower gastrointestinal tract, pancreas, and/or bladder.... Case Western Reserve University

07/13/17 / #20170196908

Compositions and methods of treating diabetic retinopathy

A method of treating diabetic retinopathy in a subject in need thereof includes administering to the subject a therapeutically effective amount of one or more agents that act as a trap of reactive aldehydes and/or inhibit diabetes-induced superoxide generation and capillary degeneration regulated by GPCR signaling pathways.... Case Western Reserve University

07/06/17 / #20170189366

Method for treating disorders related to complement activation

A method for treating or preventing a complement activated T-cell mediated disorder in a subject includes administering a therapeutically effective amount of a pharmaceutical composition to the subject. The pharmaceutical composition includes at least one amidine compound or pharmaceutically acceptable salt.... Case Western Reserve University

07/06/17 / #20170191942

Systems and methods for detecting an optical change indicating the presence of an analyte

One aspect of the present disclosure relates to an analyte sensor device. The analyte sensor device can include an optode layer that undergoes an optical change in the presence of an analyte. The analyte sensor device can also include a selectively-permeable membrane encapsulating the optode layer to form a stable... Case Western Reserve University

07/06/17 / #20170192006

Biomarkers for human monocyte myeloid0derived suppresor cells

A method for diagnosing an increased risk of a cancer in a subject includes the steps of obtaining a blood sample from the subject and determining, in the blood sample, a level of two or more of the polypeptides selected from the group consisting of VNN2, KCNJ15, SERPINB2, CREB5, ICAM3,... Case Western Reserve University

07/06/17 / #20170193175

Prediction of recurrence of non-small cell lung cancer

Methods, apparatus, and other embodiments associated with predicting non-small cell lung cancer (NSCLC) patient response to adjuvant chemotherapy therapy using radiomic features extracted from digitized hematoxylin and eosin (H&E) stained slides of a region of tissue demonstrating NSCLC. One example apparatus includes an image acquisition circuit that acquires an H&E... Case Western Reserve University

07/06/17 / #20170193655

Radiomic features on diagnostic magnetic resonance enterography

Methods, apparatus, and other embodiments associated with predicting Crohn's Disease (CD) patient response to immunosuppressive (IS) therapy using radiomic features extracted from diagnostic magnetic resonance enterography (MRE). One example apparatus includes an image acquisition circuit that acquires an MRE image of a region of tissue demonstrating CD pathology, a segmentation... Case Western Reserve University

07/06/17 / #20170193657

Prediction of recurrence of non-small cell lung cancer with tumor infiltrating lymphocyte (til) graphs

Methods and apparatus predict non-small cell lung cancer (NSCLC) recurrence using radiomic features extracted from digitized hematoxylin and eosin (H&E) stained slides of a region of tissue demonstrating NSCLC. One example apparatus includes an image acquisition circuit that acquires an image of a region of tissue demonstrating NSCLC, a segmentation... Case Western Reserve University

06/29/17 / #20170181652

System and mapping activity in peripheral nerves

Systems and methods are provided for controlling an entity in response to activity in a peripheral nerve comprising a plurality of fascicles. A multicontact electrode assembly is configured to record activity from the peripheral nerve. A processing component includes a sensor mapping component configured to quantify activity associated with a... Case Western Reserve University

06/29/17 / #20170182312

Neural electrodes and methods for implanting same

One aspect of the present disclosure can include a method for implanting a neural electrode in a fascicle including a target nerve. One step of the method can include inserting a microwire assembly into the fascicle. The microwire assembly can comprise a microwire body that is coiled around a needle... Case Western Reserve University

06/29/17 / #20170183629

Engineered tissue constructs

A modular engineered tissue construct includes a plurality of fused self-assembled, scaffold-free, high-density cell aggregates. At least one cell aggregate includes a plurality of cells and a plurality of biocompatible and biodegradable nanoparticles and/or microparticles that are incorporated within the cell aggregates. The nanoparticles and/or microparticles acting as a bulking... Case Western Reserve University

06/29/17 / #20170184564

Sensor for nitric oxide detection

A sensor for detecting nitric oxide includes a substrate, a working electrode formed on a surface of the substrate, a counter electrode formed on the surface of the substrate, a dielectric layer covering a portion of the working electrode and counter electrode and defining an aperture exposing other portions of... Case Western Reserve University

06/29/17 / #20170185730

Machine learning approach to selecting candidates

Example apparatus and methods concern a clinical decision support system for the selection of candidates. A clinical decision support system includes a candidate data logic that receives electronic data that identifies candidate data, including symptom and non-symptom data, for a candidate. The clinical decision support system also includes a scoring... Case Western Reserve University

06/22/17 / #20170173028

Compositions and methods of modulating short-chain dehydrogenase activity

Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.... Case Western Reserve University

Patent Packs
06/22/17 / #20170174862

Elastomeric and viscoelastic materials formed from poly(acrylic acid) gels

Disclosed herein are novel materials and methods of forming those novel materials. The materials are synthesized from Poly(acrylic acid), a crosslinker; and a salt. The material can be further synthesized from sodium hydroxide. The crosslinker can be a covalent crosslinking agent such as N,N′-methylenebisacrylamide. Examples of applicable salts are calcium... Case Western Reserve University

06/22/17 / #20170176469

Molecular probes for detecting lipids

A method of detecting aberrant lipid accumulation in a subject includes administering to the subject a molecular probe that includes a fluorescent trans stilbene derivative or stilbenzene derivative and detecting the amount or distribution of the molecular probe in a tissue of interest of the subject.... Case Western Reserve University

06/22/17 / #20170176470

Detection of carboxyalkylpyrrole or pentylpyrrole ethanolamine phospholipids

A method of detecting carboxyalkylpyrrole ethanolamine phospholipids (CAP-EPs) or pentylpyrrole ethanolamine phospholipids (CAP-EPs) in a bodily sample from a subject includes obtaining a bodily sample from a subject suspected of including carboxyalkylpyrrole ethanolamine phospholipids (CAP-EPs) or pentylpyrrole ethanolamine phospholipids (PP-EPs) extracting carboxyalkylpyrrole ethanolamine phospholipids or pentylpyrrole ethanolamine phospholipids from the... Case Western Reserve University

06/15/17 / #20170165241

Compositions and methods of modulating 15-pgdh activity

Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors and 15-PGDH activators described herein.... Case Western Reserve University

06/15/17 / #20170165322

Peptide and small molecule agonists of epha and their uses in disease

A method of treating a neoplastic disorder in a subject includes administering to a Eph kinase expressing neoplastic cell of the subject being treated an EphA agonist and at least one immunosuppressant.... Case Western Reserve University

06/15/17 / #20170165489

Load-preserving defining anisotropy in volume-conductor models

Example systems and methods concern systems and methods for modeling conduction in a volume. In one embodiment, diffusion eigenvalues of a plurality of diffusion tensors are received. The diffusion tensors are associated with an anatomical structure having heterogeneous and anisotropic tissues. In one embodiment, the diffusion eigenvalues of the diffusion... Case Western Reserve University

06/15/17 / #20170166720

Tannin-modified porous material and methods of making same

The present disclosure provides an aerogel formed of a tannin-containing porous material including a polymeric material, a tannin, and a clay. In some embodiments, the tannin-containing porous material is produced by forming an aerogel precursor including a polymeric material, a tannin, and a liquid dispersion medium; freezing the aerogel precursor;... Case Western Reserve University

06/15/17 / #20170169566

Automated analysis of intravascular oct image volumes

This disclosure provides systems and methods to automatically classify stent struts as covered or uncovered and to measure the thickness of tissue coverage. As one example, the method includes storing three-dimensional image data acquired intravascularly via an optical coherence tomography (OCT) apparatus and detecting struts based on analysis of the... Case Western Reserve University

06/08/17 / #20170157073

Peptide and small molecule agonists of epha and uses thereof

Methods and compositions for activating an EphA receptor can be used for identifying therapeutic agents for cancer.... Case Western Reserve University

06/08/17 / #20170161891

Scaling up convolutional networks

Methods, apparatus, and other embodiments associated with classifying a region of tissue represented in a digitized whole slide image (WSI) using iterative gradient-based quasi-Monte Carlo (QMC) sampling. One example apparatus includes an image acquisition circuit that acquires a WSI of a region of tissue demonstrating cancerous pathology, an adaptive sampling... Case Western Reserve University

05/25/17 / #20170146513

Diagnostic devices and methods

A diagnostic device is provided that comprises a light source for transmitting a light beam through a blood sample to a light detector, and a permanent magnet, wherein one of the permanent magnet and blood sample is automatically movable relative to the other between a “HIGH” magnetic state position and... Case Western Reserve University

05/18/17 / #20170136242

Systems and methods for closed loop control to ensure a constant current output with a changing load resistance

A closed loop control system automatically ensures that an output of a device is constant. The system can receive an input to set a fixed value for a variable (e.g., a current, a heart rate, a tissue perfusion, an ion level, etc.), and this variable can be delivered to a... Case Western Reserve University

05/18/17 / #20170137488

Long-acting single-chain insulin analogues

A single-chain insulin analogue containing a basic side chain at position A8 (Arginine, Histidine, Lysine, or Ornithine), a basic side chain at position B29 (Arginine, Histidine, Lysine, or Ornithine), and a foreshortened C-domain of length 6-11 residues is provided. Residues C1 and C2 of the C-domain have a net negative... Case Western Reserve University

04/27/17 / #20170112408

Systems and methods for at home neural recording

One aspect of the present disclosure relates to a system to facilitate at home neural monitoring. The system can include a wearable device and an external device. The wearable device can include an electrode configured to be placed behind a patient's ear to record an electroencephalogram (EEG) signal; an amplifier... Case Western Reserve University

04/27/17 / #20170112892

Retinylamine derivitives for treatment of ocular disorders

A pharmaceutical composition includes a retinylamine derivative having the following formula (I): where R1 is an amino acid residue, a dipeptide or a tripeptide that is linked to the retinylamine by an amide bond.... Case Western Reserve University

Patent Packs
04/27/17 / #20170114395

Clostridium difficile culture medium

A culture medium for culturing Clostridium difficile under aerobic culture conditions, the medium includes a nutrient medium that promotes growth of Clostridium difficile and amounts of thioglycolic and L-cystine effective to consume oxygen in the culture medium and facilitate growth of Clostridium difficile.... Case Western Reserve University

04/27/17 / #20170115274

Multicellular multiparametric analysis

A system for multiparametric analysis includes a substrate and a three-dimensional (3D) cell aggregate. The substrate has a major surface and includes at least one radial electrode array. The 3D cell aggregate is disposed on the major surface of the substrate. The 3D cell aggregate has a longitudinal surface at... Case Western Reserve University

04/20/17 / #20170105394

Mouse model of retinal degeneration

The invention is directed to a method of producing a non-human mammal having one or more pathological characteristics of retinal degeneration and/or age-related macular degeneration. In particular, the invention provides a method of producing a non-human mammal having age-related macular degeneration (AMD). The invention is also directed to non-human animals... Case Western Reserve University

04/20/17 / #20170106098

Targeting cancer cells and tissue using filamentous plant virus particles

A filamentous plant virus carrier comprising a filamentous plant virus particle that has been modified to carry an imaging agent or cytotoxic compound is described. The filamentous plant virus carrier can be used in a method of targeting cancer cells and tissue by administering it to a subject. Cancer tissue... Case Western Reserve University

04/13/17 / #20170100587

Neural prosthesis system and control

Multiple designs, systems, methods and processes for control using electrical signals recorded from clinically paralyzed muscles and nerves are presented. The discomplete neural prosthesis system and method for clinically paralyzed humans utilizes a controller. The controller is adapted to receive a volitional electrical signal generated by the human that is... Case Western Reserve University

04/13/17 / #20170100591

Methods and associated neural prosthetic devices for bridging brain areas to improve function

Methods for bridging brain sites between which there is substantially no effective communication, and associated neural prosthetic devices, are provided. A neural spike in a first neural site in a subject is detected, and a stimulus to a second neural site in the subject is delivered within a defined period... Case Western Reserve University

04/13/17 / #20170101456

Non-standard insulin analogues

An insulin analogue comprises a B-chain polypeptide containing a cyclohexanylalanine substitution at position B24 and optionally containing additional amino-acid substitutions at positions A8, B28, and/or B29. A proinsulin analogue or single-chain insulin analogue containing a B domain containing a cyclohexanylalanine substitution at position B24 and optionally containing additional amino-acid substitutions... Case Western Reserve University

04/13/17 / #20170101662

System and detecting neural injury

A detection system for determining pyruvate dehydrogenase (PDH) levels in a bodily sample includes at least one reaction solution for generating NAD+ upon combination with PDH in the bodily sample, the reaction solution including pyruvate and NADH and a biosensor for determining the level of generated NAD+.... Case Western Reserve University

04/13/17 / #20170102350

Electrochemical sensor for analyte detection

A sensor for the detection of an analyte in a biological sample includes a substrate, a working electrode and counter electrode formed on a surface of the substrate, and a receptor functionalized or chemically functionalized to a surface of an exposed portion of the working electrode. The receptor can selectively... Case Western Reserve University

04/06/17 / #20170095663

Systems and methods that provide electrical stimulation to a nerve to reduce a reflex that affects a bodily function

One aspect of the present disclosure relates to a system for electrical stimulation. A waveform generator can be configured to generate an electrical waveform. An electrode can be electrically coupled to the waveform generator and configured to deliver the electrical waveform to a nerve to reduce at least one reflex... Case Western Reserve University

03/23/17 / #20170080244

Systems and methods for fast and reversible nerve block

One aspect of the present disclosure relates a system that can quickly and reversibly block conduction in a nerve. The system can include a first nerve block modality that provides heat to the nerve to block conduction in the nerve. For example, the heat can provide the quick nerve block.... Case Western Reserve University

03/23/17 / #20170081767

Alloy surface activation by immersion in aqueous acid solution

A process for surface activation or depassivation of an article, in particular an alloy, by immersion of the alloy in an aqueous acid solution. The surface activation methods of the present invention can be performed during a relatively short period of time and achieve reductions in production costs and provide... Case Western Reserve University

03/16/17 / #20170071965

Antimetabolite agent combinations in the treatment of cancer

A method treating cancer in a subject comprises administering to the subject a therapeutically effective amount of an antimetabolite agent that induces formation of AP sites in cancer cells of the subjects and an amount AP endonuclease inhibitor effective to potentiate the cytotoxicity of the antimetabolite agent to the cancer... Case Western Reserve University

03/16/17 / #20170072026

Compositions and methods of treating root avulsion injury

A method of treating root avulsion injury in a subject in need thereof includes administering to the subject a therapeutic agent that inhibits one or more of catalytic activity, signaling, and function of PTPσ.... Case Western Reserve University

03/09/17 / #20170065626

Compositions and methods of treating of bacterial infections with beta-lactamase inhibitors

A method of treating a bacterial infection in a subject in need thereof includes administering to the subject therapeutically effective amounts of at least one β-lactam antibiotic and at least one triazolylmethyl boronic acid.... Case Western Reserve University

03/02/17 / #20170056544

Polymer nanofiber scaffolds and uses thereof

A polymer nanofiber scaffold includes a plurality of melt extruded nanofibers that are chemically modified to append surface functionality to the nanofibers.... Case Western Reserve University

02/23/17 / #20170050024

Treatment of pain using electrical nerve conduction block

Described herein are systems and methods for the treatment of pain using electrical nerve conduction block (ENCB). Contrary to other methods of pain treatment, the ENCB can establish a direct block of neural activity, thereby eliminating the pain. Additionally, the ENCB can be administered without causing electrochemical damage. An example... Case Western Reserve University

02/23/17 / #20170050364

Fiber reinforced hydrogels and methods of making same

Disclosed herein are biomaterials that include a plurality of fibers embedded in a matrix of hydrogel material. The plurality of fibers and hydrogel material are formed during one process step. In one embodiment, the plurality of fibers and hydrogel materials are formed using a multilayer coextrusion process step. Additional process... Case Western Reserve University

02/23/17 / #20170051070

Method for treating cd40-mediated diseases

A cell-permeable polypeptide includes a membrane transduction domain and a polypeptide comprising an amino acid sequence substantially homologous to the amino acid sequence of the TRAF2,3 binding domain, the cell permeable peptide inhibiting binding of TRAF2 to the TRAF2,3 binding domain of CD40 to decrease or inhibit a CD-40 activity... Case Western Reserve University

02/23/17 / #20170053090

Treatment planning and evaluation for rectal cancer via image analytics

Methods and apparatus associated with predicting colorectal cancer tumor invasiveness are described. One example apparatus includes a set of circuits, and a data store that stores radiological images of tissue demonstrating colorectal cancer. The set of circuits includes a circumferential resection margin (CRM) prediction circuit that generates a CRM probability... Case Western Reserve University

02/16/17 / #20170043051

Dry spray on hemostatic system

The invention provides for dry spray compositions comprising co-polymers comprising a core, water-soluble polymer and a peptide.... Case Western Reserve University

02/16/17 / #20170043520

Methods for layer multiplication co-extrusion of high viscous polymeric material systems

Methods for co-extruding multiple layers of materials, in particular high viscosity elastomer materials, wherein the method allows the use of either rheologically matched or unmatched elastomers. Devices for practicing the methods are disclosed. Multilayer extrudates exhibiting desirable performance can be formed from materials including high and/or low viscosity elastomers.... Case Western Reserve University








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