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Cedars sinai Medical Center patents


Recent patent applications related to Cedars sinai Medical Center. Cedars sinai Medical Center is listed as an Agent/Assignee. Note: Cedars sinai Medical Center may have other listings under different names/spellings. We're not affiliated with Cedars sinai Medical Center, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "C" | Cedars sinai Medical Center-related inventors


Exosomes and micro-ribonucleic acids for tissue regeneration

Several embodiments relate to methods of repairing and/or regenerating damaged or diseased tissue comprising administering to the damaged or diseased tissues compositions comprising exosomes. In several embodiments, the exosomes comprise one or more microRNA that result in alterations in gene or protein expression, which in turn result in improved cell... Cedars sinai Medical Center

Method for detecting anti-vinculin antibodies in a subject with an ibs symptom

Described herein are methods and systems for the detection of anti-vinculin antibodies, for determining a presence or likely presence of a gastrointestinal motility disorder, bladder motility disorder, or fibromyalgia. Further provided are methods of selecting and/or administering a therapy based on the presence or absence of anti-vinculin antibodies.... Cedars sinai Medical Center

Devices, systems, and methods to optimize annular orientation of transcatheter valves

In various embodiments, provided herein are methods, devices and systems to optimize annular orientation of transcatheter valves and thereby facilitate transcatheter aortic valve replacement in the setting of challenging cardiovascular anatomy. These methods, devices and systems are used to treat patients with valvular diseases. To solve these problems, described herein... Cedars sinai Medical Center

Methods and use of compounds that bind to rela of nf-kb

The invention provides methods and agents that modulate RelA activity. These methods and modulators of RelA activity can be used to treat cancer progression of basal-like breast cancer, such as triple-negative breast cancer.... Cedars sinai Medical Center

Targeting fungi in combination with cancer therapy

Described herein are methods for the treatment of cancer by modulating fungal populations to enhance the therapeutic response to a cancer therapy. In particular, the present invention discloses modulating the fungal microbiome in combination with a cancer therapy to enhance the anti-tumor effect.... Cedars sinai Medical Center

Methods of diagnosis, selection, and treatment of diseases and conditions caused by or associated with methanogens

The invention described herein provides for methods and systems for determining, selecting, and/or treating diseases and conditions caused by or associated with high quantities of methanogens in a subject, or diseases and conditions caused by or associated with low quantities of methanogens in a subject. In various embodiments, a therapy... Cedars sinai Medical Center

Transcription factor-based generation of pacemaker cells and methods of using same

Several embodiments disclosed herein relate generally to methods and compositions for the generation of biological pacemakers. In some embodiments, the methods comprise contacting non-pacemaker cells with one or more transcription factors (in vivo or in vitro) and inducing pacemaker functionality in the cells.... Cedars sinai Medical Center

Automated delineation of nuclei for three dimensional (3-d) high content screening

In various embodiments, the invention teaches systems and methods for analyzing an image of cells, including an image obtained by confocal microscopy, and delineating cell nuclei in the image. In some embodiments, the systems and methods apply a three-dimensional (3-D) radial symmetry transform followed by adaptive post processing of symmetry... Cedars sinai Medical Center

Targeting trastuzumab-resistant her2+ breast cancer with a her3-targeting nanoparticle

Disclosed herein are methods of treating cancer in a patient, the method comprising identifying a patient who is resistant to treatment with an anti-HER2 therapy; and administering to the patient a drug delivery molecule, comprising a polypeptide molecule adapted to target and/or penetrate a type of cell; a nucleic acid... Cedars sinai Medical Center

Development of spinal cord on a microfluidic chip

The invention relates to culturing brain endothelial cells, and optionally astrocytes and neurons in a fluidic device under conditions whereby the cells mimic the structure and function of the blood brain barrier. Culture of such cells in a microfluidic device, whether alone or in combination with other cells, drives maturation... Cedars sinai Medical Center

Methods of treating inflammatory bowel disease with ifn-gamma therapy

The present invention describes methods for treating inflammatory disorders of the gastrointestinal tract, including but not limited to Inflammatory Bowel Disease (IBD), Crohn's Disease (CD), Ulcerative Colitis (UC) and/or medically refractory ulcerative colitis (MR-UC) using anti-IFNG therapy. The present invention also describes a process for patient risk stratification.... Cedars sinai Medical Center

Biomarker based prognostic model for predicting overall survival in patients with metastatic clear cell kidney cancer

The present invention describes a method of using a molecular prognostic signature, to predict overall survival in patients with metastatic clear cell renal cell carcinoma. The present invention also describes a method of selecting therapy and a process for patient risk stratification based on the molecular prognostic signature analysis.... Cedars sinai Medical Center

Diagnostic biomarker to identify women at risk for preterm delivery

The invention relates to biomarkers associated with preterm delivery. More specifically, the invention provides methods of measuring biomarkers found in women that are at risk for preterm delivery.... Cedars sinai Medical Center

Self-assembling complex for targeting chemical agents to cells

The present invention relates to a complex that can be injected into the body to hone in on target cells to deliver molecules. In one embodiment, the invention provides a drug delivery system that includes components that self-assemble into one targeted conjugate. In another embodiment, the invention includes a targeted... Cedars sinai Medical Center

Methods and systems for performing tissue classification using multi-channel tr-lifs and multivariate analysis

Described herein are methods and systems for analyzing a sample by applying time resolved laser induced fluorescence spectroscopy to the sample to measure lifetime time decay profile data relating to the sample, and applying multivariate analysis to process the data so as to classify a sample as, for example, normal... Cedars sinai Medical Center

Novel and efficient reprogramming blood to induced pluripotent stem cells

Described herein are methods and compositions related to generation of induced pluripotent stem cells (iPSCs). Improved techniques for establishing highly efficient, reproducible reprogramming using non-integrating episomal plasmid vectors. Using the described reprogramming protocol, one is able to consistently reprogram non-T cells with close to 100% success from non-T cell or... Cedars sinai Medical Center

Treatment of inflammatory conditions by modulation of hyaluronan and hyaluronidase activity

The present invention describes compositions and related methods and kits for treating a variety of inflammatory conditions and infections. The therapeutic compositions include certain hyaluronidases capable of generating hyaluronan disaccharides when combined with hyaluronan, and/or the hyaluronan disaccharides themselves, and/or inflammatory hyaluronidase inhibitors. The invention further discloses the use of... Cedars sinai Medical Center

Polymalic acid-based nanobiopolymer compositions

Nanobiopolymeric conjugates based on biodegradable, non-toxic and non-immunogenic poly (β-L-malic acid) PMLA covalently linked to molecular modules that include morpholino antisense oligonucleotides (AONa), an siRNA or an antibody specific for an oncogenic protein in a cancer cell, and an antibody specific for a transferrin receptor protein, are provided. Methods for... Cedars sinai Medical Center

Device, cancer prognosis and uses thereof

Modules, devices, systems and methods for measuring or detecting cysteine and/or methionine metabolite levels in a sample from a subject are disclosed. Various embodiments of the present invention concern modules, devices, systems and methods for prognosing or diagnosing cancer, for example, prostate, colon, ovarian or breast cancer; predicting the risk... Cedars sinai Medical Center

Cardiovascular access and device delivery system

A system and method of accessing a heart of a patient is provided. A cardiac access channel is established through an apical wall of the heart to provide direct access through the apical wall to the left ventricle. A vascular access channel is established through the skin to a peripheral... Cedars sinai Medical Center

Citrullinated proteins: a post-translated modification of myocardial proteins as marker of physiological and pathological disease

Disclosed herein are methods for diagnosing cardiovascular disease. The methods comprise detection of citrullinated proteins.... Cedars sinai Medical Center

Respiratory phase-resolved 3d body imaging using iterative motion correction and average

A method for performing 3D body imaging includes performing a 3D MRI acquisition of a patient to acquire k-space data and dividing the k-space data into k-space data bins. Each bin includes a portion of the k-space data corresponding to a distinct breathing phase. 3D image sets are reconstructed from... Cedars sinai Medical Center

Polarization of macrophages to a healing phenotype by cardiosphere-derived cells and by the exosomes secreted by such cells

Described herein are compositions and techniques related to generation and therapeutic application of stem cell-derived exosomes. The Inventors have discovered cardiosphere-derived cells (CDCs) and their secreted exosomes mediate such inflammatory processes, by, for example, shifting macrophages away from a proinflammatory M1 phenotype toward M2 healing phenotype. This suggests compositions and... Cedars sinai Medical Center

System for automotive quality of life program

A method and system to gather and evaluate quality of life data is disclosed. A controller is provided in a vehicle to ask a series of questions relating to quality of life to a person in the vehicle via a speaker system. The controller receives responses to the questions orally... Cedars sinai Medical Center

Cardiosphere-derived cells (cdcs) as therapeutic agents for pulmonary hypertension

Described herein are compositions and techniques for treatment of disease and conditions such as pulmonary arterial hypertension (PAH). Unlike palliative or preventive measures that do not address the abnormal vasculature causing onset of right ventricular compensation the use of stem cell-based therapy can directly impact the microvascular pathology in PAH,... Cedars sinai Medical Center

Method of assessing disease condition of cancer

A method, system and computer-readable medium for assessing a disease condition of a cancer of a subject, including: receiving a blood sample from the subject; isolating a plurality of circulating tumor cells (CTCs) from the blood sample; measuring at least one of cell or cell nucleus sizes of each of... Cedars sinai Medical Center

Tissue classification method using time-resolved fluorescence spectroscopy and combination of monopolar and bipolar cortical and subcortical stimulator with time-resolved fluorescence spectroscopy

Provided herein are methods for classifying or characterizing a biological sample in vivo or ex vivo in real-time using time-resolved spectroscopy and/or electrical stimulation. A biological sample may produce a responsive fluorescence signal when irradiated by a light excitation signal or pulse at a predetermined wavelength. The responsive fluorescence signal... Cedars sinai Medical Center

Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of muscular dystrophy

Described herein are compositions and techniques related to generation and therapeutic application of cardiosphere-derived cells (CDCs) and CDC-derived exosomes. These cells and their secreted vesicles contain a unique milieu of biological factors, including cytokines, growth factors, transcription factors, nucleic acids including non-coding nucleic acids such as microRNAs, that serve to... Cedars sinai Medical Center

Targeting corroles for tumor toxicity and mri

Disclosed herein are compositions comprising a targeted corrole nanoparticle; and an acceptable excipient. Also disclosed are compositions comprising a targeted corrole nanoparticle; and an acceptable carrier. Further, disclosed herein are methods of imaging a condition in a subject, comprising providing a composition comprising a targeted corrole nanoparticle; administering an effective... Cedars sinai Medical Center

Early lung cancer detection by dna methylation phenotyping of sputum-derived cells

In certain embodiments, this application discloses methods for detecting lung cancer. The method includes characterization of cells extracted from human sputum, which is a valuable tissue surrogate and source of upper respiratory cells that become cancerous early in 5 the process of lung cancer development. The method includes the staining... Cedars sinai Medical Center

Systems, devices, and methods for time-resolved fluorescent spectroscopy

Provided herein are devices, systems, and methods for characterizing a biological sample in vivo or ex vivo in real-time using time-resolved spectroscopy. A light source generates a light pulse or continuous light wave and excites the biological sample, inducing a responsive fluorescent signal. A demultiplexer splits the signal into spectral... Cedars sinai Medical Center

Drug delivery of temozolomide for systemic based treatment of cancer

The present invention relates to methods of drug delivery for the treatment of a condition or disease, such as cancer. In one embodiment, the invention provides a method of preparing a multifunctional nanoconjugate of temozolomide (TMZ) by conjugating TMZ in its hydrazide form to a polymalic acid platform. In another... Cedars sinai Medical Center

Method and percutaneous delivery and deployment of a cardiac valve prosthesis

Catheter apparatuses and methods are provided for repairing heart valves, particularly mitral valves. The method includes providing a catheter having an elongate, flexible body, with a proximal end and a distal end. The distal end can be transluminally advanced from the left atrium through the mitral valve. A distal anchor... Cedars sinai Medical Center

Methods for prognosing heart transplant

Provided herein is a method, comprising: obtaining a sample from the subject; assaying the sample to detect the risk alleles at one or more SNPs; calculating a genetic risk score (GRS) of the subject based on the detected risk alleles at the one or more SNPs; determining that the subject... Cedars sinai Medical Center

Systems and methods for magnetic resonance black-blood thrombus imaging in detection of cerebral venous thrombosis

In various embodiments, the present invention teaches systems and methods for using T1-weighted black-blood MR imaging, with which a CVT can be well isolated from the surrounding tissues due to the signal suppression of flowing blood. In some embodiments, the invention teaches using black-blood imaging (3D variable-flip-angle turbo spin-echo acquisition)... Cedars sinai Medical Center

08/10/17 / #20170226478

Neuromuscular junction: nmj-on-chip

The invention relates to culturing motor neuron cells together with skeletal muscle cells in a fluidic device under conditions whereby the interaction of these cells mimic the structure and function of the neuromuscular junction (NMJ) providing a NMJ-on-chip. Good viability, formation of myo-fibers and function of skeletal muscle cells on... Cedars sinai Medical Center

07/06/17 / #20170189471

Compositions and methods for treating fibrosis

The invention provides methods for treating fibrosis and/or cancer in a subject in need thereof. The methods include providing a composition comprising an inhibitor of IL-4/IL-13 receptor function and administering an effective amount of the composition to the subject to treat fibrosis and/or cancer.... Cedars sinai Medical Center

07/06/17 / #20170189474

Antifungal therapy for the treatment of hirschsprung-associated enterocolitis

The present invention provides for methods and systems for the treatment and diagnosis of Hirschsprung-associated enterocolitis. Treatment of Hirschsprung-associated enterocolitis can include providing and administering an antifungal agent or a combination of an antifungal agent and an antibiotic. Diagnosis of Hirschsprung-associated enterocolitis can include the detection of fungal species by... Cedars sinai Medical Center

06/22/17 / #20170173130

Cancer vaccines and vaccination methods

Methods and compositions for treating cancers (e.g., neural cancers) by dendritic cell vaccination are provided herein.... Cedars sinai Medical Center

06/22/17 / #20170174760

Method for treating antibody-mediated rejection post-transplantation

Described herein are methods for treating antibody mediated rejection of transplanted organs using inhibitors of IL-6. In one embodiment, the IL-6 inhibitor is Tocilizumab and is administered simultaneously or sequentially with intravenous immunoglobulin (IVIG).... Cedars sinai Medical Center

06/15/17 / #20170166967

Methods of using single nucleotide polymorphisms in the tl1a gene to predict or diagnose inflammatory bowel disease

This invention provides methods of diagnosing or predicting susceptibility to Inflammatory Bowel Disease by determining the presence or absence of genetic variants in the TL1A gene. In one embodiment, a method of the invention is practiced by determining the presence or absence of TL1A production following Fc-gamma-R activation. In another... Cedars sinai Medical Center

05/25/17 / #20170148349

Methods and kits for identifying food sensitivities and intolerances

Described herein are kits and methods for identifying the likelihood of having a food sensitivity or intolerance, and determining dietary modifications accordingly. For example, the likelihood of having sensitivities, intolerances or allergies to gluten, lactose, FODMAPs and others tested and calculated. Additionally, diet modifications can be determined according to the... Cedars sinai Medical Center

05/04/17 / #20170119823

Method for non surgical repair of vertebral compression fractures

Described herein are methods and compositions using PTH and mesenchymal stem cells (MSCs) for treatment of osteoporosis, bone fractures, and related conditions. Administration of both PTH and MSCs leads to increased homing of MSCs to sites of vertebral bone and rib fracture. The described methods and compositions provide therapeutic approaches... Cedars sinai Medical Center

05/04/17 / #20170121297

Compositions and methods for treating cancers

The invention describes compounds that inhibit both HDAC and GSK3β (i.e., HDAC/GSK3β dual inhibitors). The invention further describes compositions containing these HDAC/GSK3β dual inhibitors, as well as methods and kits using these HDAC/GSK3β dual inhibitors to treat various medical conditions. The invention also provides methods and kits using a HDAC... Cedars sinai Medical Center

04/27/17 / #20170112897

Methods for treating brain insulin resistance

The invention provides methods for treating brain insulin resistance and/or diseases associated therewith in a subject in need thereof. The methods include providing a composition comprising a dual GLP-1 receptor/GIP receptor (GLP-1R/GIPR) agonist and administering an effective amount of the composition to the subject to treat brain insulin resistance and... Cedars sinai Medical Center

04/27/17 / #20170113068

Ultrasonic bath to increase tissue perfusion

The present invention describes a method of using an ultrasonic bath to enhance tissue perfusion, enhance the development of collateral blood vessels and/or enhance collateral circulation in an extremity in need thereof. Also described is an ultrasonic bath for the inventive method.... Cedars sinai Medical Center

04/20/17 / #20170107498

Novel and efficient reprogramming immortalized lymphoblastoid cell lines to induced pluripotent stem cells

Described herein are methods and compositions related to generation of induced pluripotent stem cells (iPSCs). Improved techniques for establishing highly efficient, reproducible reprogramming using non-integrating episomal plasmid vectors, including generation of iPSCs from lymphoblastoid B-cells and lymphoblastoid B-cell lines. Such methods and compositions find use in regenerative medicine applications.... Cedars sinai Medical Center

04/06/17 / #20170095543

Methods of diagnosing and treating small intestinal bacterial overgrowth (sibo) and sibo-related conditions

Disclosed is a method of treating small intestinal bacterial overgrowth (SIBO) or a SIBO-caused condition in a human subject. SIBO-caused conditions include irritable bowel syndrome, fibromyalgia, chronic pelvic pain syndrome, chronic fatigue syndrome, depression, impaired mentation, impaired memory, halitosis, tinnitus, sugar craving, autism, attention deficit/hyperactivity disorder, drug sensitivity, an autoimmune... Cedars sinai Medical Center

03/30/17 / #20170088601

Cd133 epitopes

An immunogen includes an isolated peptide of 800 amino acid residues or fewer having the amino sequence ILSAFSVYV (SEQ ID NO:1) with four or fewer amino acid substitutions, a superagonist variant of SEQ ID NO:1, or an amino acid sequence having the formula: (I/K/T/V/M)-L-(S/L)-(A/E/N/D/Q)-(F/V)-(S/M/V/I)-(V/D/R/G/H)-Y-(V/I/L) (SEQ ID NO:13). The immunogens can... Cedars sinai Medical Center

03/16/17 / #20170074959

Motion corrected simultaneously acquired multiple contrast coronary mri systems and methods

In various embodiments, the present application discloses systems and methods for magnetic resonance imaging (MRI) of coronary arteries. In various embodiments, the invention allows for motion corrected, simultaneously acquired multiple contrast weighted images with whole-heart coverage and isotropic high resolution. In some embodiments, the invention teaches using interleaved preparatory pulses,... Cedars sinai Medical Center

02/16/17 / #20170044615

Methods of predicting medically refractive ulcerative colitis (mruc) requiring colectomy

The present invention relates to methods of predicting the risk for colectomy in a subject with mrUC, by determining the presence or absence of one or more mrUC risk variants. Other embodiment, relate to methods of treating mrUC in a subject and a kit for prognostic use.... Cedars sinai Medical Center

02/09/17 / #20170038393

Diagnosis and treatment of irritable bowel syndrome and inflammatory bowel disease

The present invention describes methods, assays, and systems of diagnosing, selecting and treating irritable bowel syndrome (IBS) based on a subject's level of anti-vinculin and anti-CdtB antibodies. IBS can be distinguished from inflammatory bowel (IBD) disease using the methods, assays, and systems described herein.... Cedars sinai Medical Center

01/26/17 / #20170021016

Combination therapy with cd4 lymphocyte depletion and mtor inhibitors

The invention provides methods for treating a malignant neoplastic cell proliferative disorder or disease, comprising administering to a subject in need thereof an effective amount of an mTOR inhibitor and an effective amount of a CD4 lymphocyte depleting agent. Such methods find utility in the treatment of certain subsets of... Cedars sinai Medical Center

01/26/17 / #20170022280

Method for treating antibody-mediated rejection post-transplantation

Described herein are methods for treating antibody mediated rejection of transplanted organs using inhibitors of IL-6. In one embodiment, the IL-6 inhibitor is Tocilizumab and is administered simultaneously or sequentially with intravenous immunoglobulin (IVIG).... Cedars sinai Medical Center

01/12/17 / #20170007698

Methods and compositions for treating cancer and infectious diseases

The invention relates to compositions comprising a CD4 lymphocyte depleting agent; and methods of using the compositions to treat, prevent, reduce the severity of and/or slow the progression of a condition in a subject. The invention also relates to use of combinations of a CD4 lymphocyte depleting agent and at... Cedars sinai Medical Center








ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009



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