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Cellular Research Inc patents


Recent patent applications related to Cellular Research Inc. Cellular Research Inc is listed as an Agent/Assignee. Note: Cellular Research Inc may have other listings under different names/spellings. We're not affiliated with Cellular Research Inc, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "C" | Cellular Research Inc-related inventors


Measurement of protein expression using reagents with barcoded oligonucleotide sequences

Some embodiments disclosed herein provide a plurality of compositions each comprising a protein binding reagent conjugated with an oligonucleotide. The oligonucleotide comprises a unique identifier for the protein binding reagent it is conjugated with, and the protein binding reagent is capable of specifically binding to a protein target. Further disclosed... Cellular Research Inc

Methods and compositions for labeling targets and haplotype phasing

Disclosed herein are methods for estimating the copy number of a target chromosome in a sample. In some embodiments, the methods include: partitioning a sample comprising one or more copies of the first target chromosome, into a plurality of partitioned samples; stochastically barcoding the one or more copies of the... Cellular Research Inc

Enzyme-independent molecular indexing

The present disclosure relates to compositions, methods and kits for quantitative analysis of a plurality of nucleic acid target molecules in a sample. In some embodiments, the methods comprise associating molecular label sequences with target nucleic acid molecules without an enzymatic reaction.... Cellular Research Inc

Massively parallel single cell analysis

The disclosure provides for methods, compositions, and kits for multiplex nucleic acid analysis of single cells. The methods, compositions and systems may be used for massively parallel single cell sequencing. The methods, compositions and systems may be used to analyze thousands of cells concurrently. The thousands of cells may comprise... Cellular Research Inc

Molecular indexing of internal sequences

The present disclosure relates to compositions, methods and kits for labeling an internal sequence of a target nucleic acid molecule with molecular barcodes. In some embodiments, the methods comprise intramolecular circulation of a labeled target nucleic acid molecule. Further provided methods for generating sequencing libraries comprising overlapping fragments covering the... Cellular Research Inc

Error correction in amplification of samples

Disclosed herein are methods and systems for correcting errors in sample amplification, including the errors occurred in determining the number of targets in samples. In some embodiments, the method comprises: stochastically barcoding a plurality of targets in the samples using oligonucleotides comprising stochastic barcodes to generate stochastically barcoded targets; contacting... Cellular Research Inc

Normalization of nucleic acid libraries

This disclosure provides methods and compositions for removing one or more high abundance species from a plurality of nucleic acid molecules. In some embodiments, the methods and compositions can be used for normalizing nucleic acid libraries. In some embodiments, molecular labels are used in conjunction with the methods and compositions... Cellular Research Inc

Molecular label counting adjustment methods

Disclosed herein are methods and systems for determining the numbers of targets. In some embodiments, the method comprise: stochastically barcoding targets using stochastic barcodes; obtaining sequencing data; for one or more of the targets: counting the number of molecular labels with distinct sequences associated with the target in the sequencing... Cellular Research Inc

Spatially addressable molecular barcoding

The disclosure provides for methods, compositions, systems, devices, and kits for determining the number of distinct targets in distinct spatial locations within a sample. In some examples, the methods include: stochastically barcoding the plurality of targets in the sample using a plurality of stochastic barcodes, wherein each of the plurality... Cellular Research Inc

Accurate molecular barcoding

In accordance with some embodiments herein, compositions and methods for accurate barcoding of nucleic acids are described. The compositions and methods can involve a plurality of unique oligonucleotide species comprising unique molecule barcodes. In some embodiments, the molecule barcodes can have a relatively low G content, and can exhibit reduced... Cellular Research Inc

Methods and systems for digitally counting features on arrays

Methods, systems and platforms for digital imaging of multiple regions of an array, and detection and counting of the labeled features thereon, are described.... Cellular Research Inc

Methods and compositions for library normalization

The disclosure provides for methods, compositions, and kits for normalizing nucleic acid libraries, for example sequencing libraries.... Cellular Research Inc








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