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Centre National De La Recherche Scientifique cnrs
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Centre National De La Recherche Scientifique cnrs patents


Recent patent applications related to Centre National De La Recherche Scientifique cnrs. Centre National De La Recherche Scientifique cnrs is listed as an Agent/Assignee. Note: Centre National De La Recherche Scientifique cnrs may have other listings under different names/spellings. We're not affiliated with Centre National De La Recherche Scientifique cnrs, we're just tracking patents.

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Process for preparing polyols

The present invention relates to a process for preparing polyols. In particular, the present invention relates to the preparation, in a single step, of polyols by a process involving a hydrohydroxymethylation reaction starting from a composition A comprising one or more compounds of formula (I).... Centre National De La Recherche Scientifique cnrs

Material and process for obtaining same

The invention relates to a material comprising: a first crosslinked polymer forming a network, and a second linear polymer comprising n monomers, each of the monomers having the following formula I: (I), where m varies from 0 to 4, R is selected from hydrogen, an ethyl group and an alkyl... Centre National De La Recherche Scientifique cnrs

Lipid based nanocarrier compositions loaded with metal nanoparticles and therapeutic agent

The invention relates to non-polymeric lipid-based nanocarrier compositions loaded with metal nanoparticles and at least one therapeutic agent, useful agents for transportation, vectorization, cellular delivery cellular targeting or cellular localization of at least one therapeutic agent.... Centre National De La Recherche Scientifique cnrs

Substituted quinazoline derivatives as dna methyltransferase inhibitors

The present invention relates to compounds of the following formula (I) and pharmaceutically acceptable salts and solvates thereof, their methods of preparation, their use as a drug, notably in the treatment of cancer, and pharmaceutical compositions containing such compounds.... Centre National De La Recherche Scientifique cnrs

Material and process for obtaining same

The invention relates to a material comprising: a first crosslinked polymer forming a network, and a second linear polymer comprising n monomers, each of the monomers having the following formula I: (I), where m varies from 0 to 4, R is selected from hydrogen, an ethyl group and an alkyl... Centre National De La Recherche Scientifique cnrs

Use of a withania extract for the treatment of alpha synucleinopathies

The invention relates to the use of a composition from a plant extract of Withania somnifera, to prevent, treat of delay the progression of α-synuclemopathies, including Parkinson disease.... Centre National De La Recherche Scientifique cnrs

Polypeptide having the capacity to form alpha-1,3 glucosyl unit branchings on an acceptor

Polypeptides having the ability to specifically form connections of glucosyl units in alpha 1,3 on an acceptor having at least one hydroxyl moiety are presented. The polypeptides include i) the pattern I of sequence SEQ ID NO: 1, ii) the pattern II of sequence SEQ ID NO: 2, iii) the... Centre National De La Recherche Scientifique cnrs

Isolated peptides and fragments thereof from fibrinogen for use as drugs, particuarly in skin inflammatory diseases

A present invention relates to isolated peptides obtained from human fibrinogen for their use as drug, particularly for the prevention and/or the treatment of inflammatory skin diseases, more particularly acne. The present invention also relates to fragments of these polypeptides, nucleic acid molecules encoding them, expression vectors, host cells, a... Centre National De La Recherche Scientifique cnrs

Formation of hairpins in situ using force-induced strand invasion

The present invention relates to a method of preparation of substrates for nucleic acid sequencing reactions. More specifically, the present invention provides a new method of preparing hairpins using force-induced strand invasion. Hairpins prepared by this method and methods of nucleic acid analysis using these hairpins are also part of... Centre National De La Recherche Scientifique cnrs

Free space optical communications device

The invention relates to a free space optical communications device (10) multiplexed in wavelengths of between 400 nm and 1600 nm, said device including demultiplexing means (11) that are designed so as to separately dissociate a number n1 of wavelengths from one another, the demultiplexing means (11) including one or... Centre National De La Recherche Scientifique cnrs

Optical system for shaping the wavefront of the electric field of an input light beam

The present invention concerns an optical system for shaping the wavefront of the electric field of an input light beam (1) to be projected into a target volume (5), including: —a first optical element (2), which is a spatial light modulator used to control light distribution in at least one... Centre National De La Recherche Scientifique cnrs

Single-phase alloy of gold and tungsten

A single-phase alloy is formed, as weight percentages, of N % of gold, M % of tungsten, with N+M=100, M≧8 and N≧60. Also disclosed is a process for preparing such an alloy use of such an alloy and decorative sheets made from such an alloy.... Centre National De La Recherche Scientifique cnrs

Single-phase alloy of gold and tungsten

A single-phase alloy is formed, as weight percentages, of N % of gold, M % of tungsten, with N+M=100, M≧8 and N≧60. Also disclosed is a process for preparing such an alloy use of such an alloy and decorative sheets made from such an alloy.... Centre National De La Recherche Scientifique cnrs

Method for tuning one or more resonator(s)

The invention concerns a method for tuning at a targeted resonance wavelength at least one micro and/or nanophotonic resonator, the resonator having dimensions defining resonance wavelength of said resonator, the resonator being immersed in a fluid containing ions so that the resonator is surrounded by said fluid, wherein the method... Centre National De La Recherche Scientifique cnrs

Method for tuning one or more resonator(s)

The invention concerns a method for tuning at a targeted resonance wavelength at least one micro and/or nanophotonic resonator, the resonator having dimensions defining resonance wavelength of said resonator, the resonator being immersed in a fluid containing ions so that the resonator is surrounded by said fluid, wherein the method... Centre National De La Recherche Scientifique cnrs

Molecular targets for the prevention and/or treatment of fibrosis, hypertrophic scars or keloids

The present invention relates to a therapeutic compound comprising: an agent that inhibits the activity of at least one gene selected from the group consisting of HIC1, FOXS1, CREB5, IRF7, POU2F2, STAT4, TCF4, and/or an agent that enhances the activity of at least one gene selected from the group consisting... Centre National De La Recherche Scientifique cnrs

Methods and pharmaceutical composition for the treatment and the prevention of neurological phenotype associated with friedreich ataxia

The present invention relates to a vector which comprises a nucleic acid sequence encoding for the frataxin (FXN) gene for use in the prevention and treatment of neurological phenotype associated with Friedreich ataxia in a subject in need thereof.... Centre National De La Recherche Scientifique cnrs

Use of a withania extract for the treatment of amyloid-related diseases

The invention relates to the use of a composition from a plant extract of Withania somnifera, to treat or prevent amyloid-related diseases, including Alzheimer disease.... Centre National De La Recherche Scientifique cnrs

Use of a withania extract for the treatment of amyloid-related diseases

The invention relates to the use of a composition from a plant extract of Withania somnifera, to treat or prevent amyloid-related diseases, including Alzheimer disease.... Centre National De La Recherche Scientifique cnrs

Electrode materials with high surface conductivity

The present invention concerns electrode materials capable of redox reactions by electron and alkali-ion exchange with an electrolyte. The applications are in the field of primary (batteries) or secondary electrochemical generators, supercapacitors and light modulating systems of the electrochromic type.... Centre National De La Recherche Scientifique cnrs

Method and device to assist with the operation of an instrument

The invention relates to a device and a method to assist with the operation of an instrument by means of said device, the device and the method using leverage effects in order to calculate the data relative to any point of an instrument axis, instead of using low-accuracy sensors. Other... Centre National De La Recherche Scientifique cnrs

Synthetic single domain antibody

The invention relates to the identification of a highly stable single domain antibody scaffold (hs2d Ab) and its use in generating synthetic single domain antibody library (hs2d Ab-L1). The invention also relates to antigen-binding proteins comprising said stable single domain antibody scaffold and their uses, in particular as therapeutics.... Centre National De La Recherche Scientifique cnrs

Icos binding proteins

The present invention relates to an ICOS binding protein or antigen binding portion thereof that is an agonist to human ICOS and does not induce complement, ADCC, or CDC when placed in contact with a T cell in vivo and methods of treating cancer, infectious disease and/or sepsis with said... Centre National De La Recherche Scientifique cnrs

Device for the transmission of kinetic energy from a working fluid to a receiving fluid

A system for exchanging heat from a working fluid to a receiving fluid, which includes: a device for transmitting kinetic energy from a working fluid to a receiving fluid, the device including: a circulator suitable for circulating the receiving fluid; a turbine suitable for being driven by the circulation of... Centre National De La Recherche Scientifique cnrs

Methods for predicting the responsiveness of a patient affected with malignant hematological disease to chemotherapy treatment and methods of treatment of such disease

The present invention relates to antagonists of GDF11, for use in the treatment of malignant hematological disease, such as Acute Myeloid Leukemia (AML). The present invention also relates to a method for predicting the responsiveness of a patient affected with malignant haematological disease, such as Acute Myeloid Leukemia, to a... Centre National De La Recherche Scientifique cnrs

Reprogramming producing induced pluripotent stem cells (ipsc)

The present invention is in the field of stem cells. Particularly, the present invention relates to a reprogramming method for producing induced pluripotent stem cells (iPSC) by transducing somatic differentiated cells with a viral vector expressing Δ133p53β isoform, Δ133p53γ isoform or both Δ133p53β and Δ133p53γ isoforms; to induced pluripotent stem... Centre National De La Recherche Scientifique cnrs

Selective porphyrin-catalyzed electrochemical reduction of co2 into co in water

The present invention relates to the use of complexes of water soluble porphyrins of formula (I) below wherein R1 to R10 and R1′ to R10′ are as defined in claim 1, with iron as catalysts for the selective electrochemical reduction of CO2 into CO, electrochemical cells comprising them, and methods... Centre National De La Recherche Scientifique cnrs

System and controlling the cyclic motion of a body segment of an individual

a feedback device coupled to the processor, designed to provide the individual with real-time information on the compliance of the parameters(s) of the measured motion with respect to the parameter(s) of the reference motion.... Centre National De La Recherche Scientifique cnrs

Polypeptides for engineering integrase chimeric proteins and their use in gene therapy

The present invention relates to polypeptide for engineering integrase chimeric proteins and their use in gene therapy. In particular, the present invention relates to a polypeptide which comprises the amino acid sequence ranging from the amino acid residue at position 617 to the amino acid residue at position 622 in... Centre National De La Recherche Scientifique cnrs

Monoclonal antibodies to progastrin and their uses

The present disclosure is directed to progastrin monoclonal antibodies, fragments thereof, compositions comprising progastrin monoclonal antibodies, and methods of making and using progastrin monoclonal antibodies and compositions thereof. The present disclosure is directed to methods of treating colorectal cancer with progastrin monoclonal antibodies and compositions comprising progastrin monoclonal antibodies or... Centre National De La Recherche Scientifique cnrs

Selective porphyrin-catalyzed electrochemical reduction of co2 into co in water

The present invention relates to the use of complexes of water soluble porphyrins of formula (I) below wherein R1 to R10 and R1′ to R10′ are as defined in claim 1, with iron as catalysts for the selective electrochemical reduction of CO2 into CO, electrochemical cells comprising them, and methods... Centre National De La Recherche Scientifique cnrs

Substrate/peptide/lipid bilayer assembly, preparation methods and associated detection methods

The invention concerns an assembly consisting of a substrate on which at least one lipid bilayer is attached by means of a peptide, referred to as the tethering peptide, which is itself linked to the substrate, characterised in that the tethering peptide has a C-terminal end constituted by at least... Centre National De La Recherche Scientifique cnrs

Compositions of thermoassociative additives with controlled association and lubricant compositions containing them

The present disclosure relates to novel compositions of additives that result from mixing at least two thermoassociative and exchangeable copolymers and at least one compound for controlling the association of these two copolymers. A lubricant composition results from mixing at least one lubricating base oil, at least two thermoassociative and... Centre National De La Recherche Scientifique cnrs

Imidazo[1,2-a]quinoxalines and derivatives thereof for the treatment of cancer

The invention relates to imidazo[1,2-a]quinoxaline compounds of formula (I) for the treatment of cancer, the pharmaceutical compositions comprising said chemical compounds, and the therapeutic uses thereof.... Centre National De La Recherche Scientifique cnrs

Antibodies specific to glycoprotein (gp) of ebolavirus and uses for the treatment and diagnosis of ebola virus infection

The present invention relates to antibodies or fragments thereof that specifically bind to glycoprotein (GP) of Ebola virus, and to their use for treating and diagnosing Ebola virus disease.... Centre National De La Recherche Scientifique cnrs

01/18/18 / #20180019120

Production of a semiconductor support based on group iii nitrides

The invention also relates to a support obtained by the method, to a semiconductor structure based on the support, and to the method for the production thereof.... Centre National De La Recherche Scientifique cnrs

01/18/18 / #20180019822

Digital-data mixing apparatus and digital-data processing system

The invention is related to a digital-data mixing apparatus (2), a data processing system (1) and an associated method for mixing digital-data. The digital-data mixing apparatus comprises, integrated in a housing (7), input means (8) for receiving a plurality of bits (I1 . . . In) of input digital data... Centre National De La Recherche Scientifique cnrs

01/11/18 / #20180009103

Planar motion device

A positioning device includes a planar surface, a mobile platform configured to slide along the planar surface and cables for positioning and moving the mobile platform along the planar surface. The mobile platform includes a planar bearing system located at the side of the mobile platform configured to slide along... Centre National De La Recherche Scientifique cnrs

01/11/18 / #20180011309

Device for transporting and controlling light pulses for lensless endo-microscopic imaging

an optical device for controlling group velocity (50) comprising a given number M of waveplates (Pj) characterized by a given delay (8tj); a first spatial light modulator (51) suitable for forming from an incident light beam a number N of elementary light beams (Bi) each of which is intended to... Centre National De La Recherche Scientifique cnrs

01/11/18 / #20180012753

Method for producing a passivated semiconductor structure based on group iii nitrides, and one such structure

two fractional order diffraction lines (0, ⅓) and (0, ⅔) between the central line (0, 0) and the integer order line (0, 1).... Centre National De La Recherche Scientifique cnrs

01/04/18 / #20180000892

Methods and pharmaceutical compositions for the treatment of ischemic conditions

The present invention relates to methods and pharmaceutical compositions for the treatment of ischemic conditions. In particular, the present invention relates to a method of treating an ischemic condition in a subject in need thereof comprising administering the subject with a polypeptide comprising an amino acid sequence having at least... Centre National De La Recherche Scientifique cnrs

01/04/18 / #20180002274

Fatty amino alcohols and process for preparing same

The present invention relates to amino alcohol compounds and to the preparation thereof from fatty esters comprising at least two carbon-carbon double bonds. In particular, the present invention relates to fatty amino alcohol compounds obtained by means of a process coupling, in a single step, a hydroaminomethylation reaction and a... Centre National De La Recherche Scientifique cnrs

01/04/18 / #20180002439

Anti-mesothelin antibodies and uses thereof

The present disclosure provides isolated nanobodies based on camelid VHH domains that specifically bind to mesothelin with high affinity. Also disclosed are conjugate constructs comprising the isolated nanobodies derivatized to allow conjugation to or that are conjugated to accessory moieties, such as biologically active moieties (e.g., a cytotoxin, a non-cytotoxic... Centre National De La Recherche Scientifique cnrs

01/04/18 / #20180002251

Catalytic process for diene dimerization

The disclosure relates to a selective head-to-head dimerization of conjugated diene compounds by a catalytic process in a reaction medium without solvent or with solvent comprising hydrocarbons, in the presence of a specific additive of the phenol type.... Centre National De La Recherche Scientifique cnrs

12/28/17 / #20170368348

Method and device for enhancing memory consolidation

The present invention relates to methods and devices to consolidate memory and/or cognitive functions by monitoring brain rhythms and delivering a stimulus at an appropriate stage of sleep cycle.... Centre National De La Recherche Scientifique cnrs

12/21/17 / #20170360752

Antiviral agents directed against respiratory syncytial virus

The present invention relates to N1-benzyl substituted pyrazoles as antiviral agents directed against respiratory syncytial virus.... Centre National De La Recherche Scientifique cnrs

12/21/17 / #20170362239

Compounds for treating cystic fibrosis

The present invention relates to compounds of Formula (I) or pharmaceutically acceptable enantiomers, salts, solvates or prodrugs thereof. The invention further relates to the use of the compounds of Formula (I) for the treatment of cystic fibrosis. The invention also relates to a process for manufacturing compounds of Formula (I).... Centre National De La Recherche Scientifique cnrs

12/21/17 / #20170362682

Method for recycling waste electrical and electronic equipment

The method for separation of metals from electronic cards includes a step of processing the electronic cards in an aqueous medium under supercritical conditions. The method also a later step of crushing solid materials coming from the treatment under supercritical conditions.... Centre National De La Recherche Scientifique cnrs

12/14/17 / #20170354709

Methods and pharmaceutical compositions for the treatment of acute exacerbations of chronic obstructive pulmonary disease

The present invention relates to methods and pharmaceutical compositions for the treatment of acute exacerbation of chronic obstructive pulmonary disease. In particular, the present invention relates to a method of treating acute exacerbation of chronic obstructive pulmonary disease in a subject in need thereof comprising administering the subject with a... Centre National De La Recherche Scientifique cnrs

12/14/17 / #20170355734

Metabolically stable apelin analogs in the treatment of disease mediated by the apelin receptor

The invention is related to metabolically stable apelin analogs and their use for the prevention or the treatment of diseases mediated by the apelin receptor in particular of cardiovascular disease (heart failure, hypertension, pulmonary hypertension, kidney failure) and inappropriate vasopressin secretions (SIADH).... Centre National De La Recherche Scientifique cnrs

12/14/17 / #20170355964

Delta133p53beta and delta133p53gamma isoforms are biomarkers of cancer stem cells

The present invention is in the field of oncology, and more particularly of cancer stem cells. It relates to a method for producing cancer stem cells based on overexpression of Δ133ρ536 isoform, Δ133ρ53γ isoform, or both Δ133ρ536 and Δ133ρ53γ isoforms; a method for predicting the risk that treatment with a... Centre National De La Recherche Scientifique cnrs

12/07/17 / #20170349907

Methods to monitor post-translational gene silencing activity in plant tissues/cell types relevant for pathogen entry, propagation or replication

The invention relates to transgenic plants comprising an inverted-repeat construct which triggers post-transcriptional gene silencing of an endogenous visual reporter gene driven by a tissue-specific promoter wherein said tissue is relevant for pathogen entry, propagation or replication and their uses for screening natural or synthetic molecules, microorganisms or extracts from... Centre National De La Recherche Scientifique cnrs

12/07/17 / #20170350889

Cell identification method

The present invention relates to the use of a nucleic acid molecule encoding a first reporter gene, bordered by at least one first pair and one second pair of sequences targeting a site-specific recombinase in order to detect cells of a mammal infected with a virus responsible for an immunodeficiency.... Centre National De La Recherche Scientifique cnrs

12/07/17 / #20170349810

Nano-inhibitors

Novel hybrid nanoparticles, useful for inhibiting or slowing down the formation of sulfur deposits or minerals in a well during the extraction of gas or oil. Specifically, the nanoparticles each include (i) a polyorganosiloxane (POS) matrix; and, optionally as a coating over a lanthanide oxide core, (iii) at least one... Centre National De La Recherche Scientifique cnrs

12/07/17 / #20170349810

Nano-inhibitors

Novel hybrid nanoparticles, useful for inhibiting or slowing down the formation of sulfur deposits or minerals in a well during the extraction of gas or oil. Specifically, the nanoparticles each include (i) a polyorganosiloxane (POS) matrix; and, optionally as a coating over a lanthanide oxide core, (iii) at least one... Centre National De La Recherche Scientifique cnrs

11/30/17 / #20170340247

Method of testing an infant and suitable device for implementing the test method

The invention relates to a method of testing an infant, comprising the following steps: displaying a target on a screen; detecting contact made by the infant with the screen inside and/or outside the target; calculating a success parameter on the basis of the contact detected; and recording the calculated success... Centre National De La Recherche Scientifique cnrs

11/23/17 / #20170335071

Composition containing bis-ureas for forming stable gels

The invention relates to a composition comprising classic bis-ureas and bis-ureas functionalised by macromolecular chains, said bis-ureas including complementary spacers of the aryl type, the mixture of said bis-ureas in a solvent leading to a stable physical gel. The invention also relates to a method for producing said composition and... Centre National De La Recherche Scientifique cnrs

11/23/17 / #20170335435

A turbine engine part including a titanium-based alloy

The present invention relates to a turbine engine part including a titanium-based alloy presenting a high level of work hardening, a high breaking load, and good ductility.... Centre National De La Recherche Scientifique cnrs

11/16/17 / #20170326246

Conjugated molecules comprising a peptide derived from the cd4 receptor coupled to an anionic polypeptide for the treatment of aids

This invention relates to a conjugated molecule comprising a peptide derived from the CD4 receptor coupled to an organic molecule by means of a linker as well as a process for its preparation. Said organic molecule comprises a 5 to 21 amino acid anionic polypeptide. Such a conjugated molecule can... Centre National De La Recherche Scientifique cnrs

11/16/17 / #20170326261

Bifunctional do2pa derivatives, chelates with metallic cations and use thereof

Disclosed are chelates resulting from the complexation of bifunctional do2pa derivatives ligands of formula (I), wherein the substituents R1, R1′, R2, R2′, R3, R3′, L1, L1′, L2 and L2′ are defined as in the claims, with metallic cations, especially Pb(II) and Bi(III). Also disclosed are bifunctional do2pa derivatives ligands of... Centre National De La Recherche Scientifique cnrs

11/16/17 / #20170327572

Treatment of acute exacerbations of chronic obstructive pulmonary disease by antagonism of the il-20r

The present invention relates to methods and pharmaceutical compositions for the treatment of acute exacerbation of chronic obstructive pulmonary disease. In particular, the present invention relates to a method of treating acute exacerbation of chronic obstructive pulmonary disease in a subject in need thereof comprising administering the subject with a... Centre National De La Recherche Scientifique cnrs

11/16/17 / #20170327896

Hemopathy prognosis method

This invention relates to an in vitro method for prognosis of the response to a chemotherapy of an individual suffering from chronic myeloid leukemia, comprising a. a step of measuring the expression level of at least one subgroup of genes chosen from a group of genes, b. a comparing step,... Centre National De La Recherche Scientifique cnrs

11/09/17 / #20170320951

Methods for diagnosing and treating cd1d restricted gamma/delta t cell lymphomas

Methods for diagnosing and treating CD1d-restricted gamma/delta T cell lymphomas are disclosed. In particular, the present disclosure relates to a method for diagnosing a T cell lymphoma as a CD1d-restricted gamma/delta T cell lymphoma in a patient in need thereof including i) detecting the presence of CD1d restricted gamma/delta T... Centre National De La Recherche Scientifique cnrs

11/09/17 / #20170321185

Efficient production of oligosaccharides using metabolically engineered microorganisms

The present invention relates to the enzymatic synthesis of oligosaccharides, particularly, sialylated oligosaccharides comprising the carbohydrate moieties of the gangliosides GM3, GD3, and G.... Centre National De La Recherche Scientifique cnrs

11/09/17 / #20170324213

Method and system for generating a high laser power

According to the invention, a plurality of elementary laser beams (fi) are generated, the phases of which are adjusted by an electro-optical feedback loop (6, 7i, 8i, 9) implementing the matrix equation of a phase-contrast filtering device (6).... Centre National De La Recherche Scientifique cnrs

Patent Packs
11/02/17 / #20170313758

Polypeptides for the treatment of angiogenesis or lymphangiogenesis-related diseases

The present invention relates to polypeptides for the treatment of angiogenesis or lymphangiogenesis-related diseases. In particular, the present invention relates to a a polypeptide which comprises or consists of a sequence of at least 5 consecutive amino acids in SEQ ID NO: 1 and which comprises at least one amino... Centre National De La Recherche Scientifique cnrs

10/26/17 / #20170304489

Time-controlled glucose releasing hydrogels and applications thereof

The present invention relates generally to a hydrogel releasing glucose in a time-controlled manner, to medical applications thereof, and to a method for preparing said hydrogel.... Centre National De La Recherche Scientifique cnrs

10/26/17 / #20170309738

Vertically structured power transistor with trench supply electrode

The invention relates to a vertically structured power transistor, such as a VD-MOS or an IGBT, having a cell comprising: two symmetrical source layers (308), preferably N+ doped, which extend from a front surface (312) of the semiconductor substrate; a well layer (307), preferably P doped, comprising an area having... Centre National De La Recherche Scientifique cnrs

10/26/17 / #20170304792

Device for synthesising and studying compounds under controlled temperatures and pressures

A device for synthesising and studying compounds under controlled temperatures and pressures includes: a body delimiting a vacuum chamber including temperature-regulation means and vacuum-application means, and having one or more viewing windows enabling the inside of the chamber to be observed from the outside; temperature-regulation means that are intended for... Centre National De La Recherche Scientifique cnrs

10/26/17 / #20170304489

Time-controlled glucose releasing hydrogels and applications thereof

The present invention relates generally to a hydrogel releasing glucose in a time-controlled manner, to medical applications thereof, and to a method for preparing said hydrogel.... Centre National De La Recherche Scientifique cnrs

10/26/17 / #20170304792

Device for synthesising and studying compounds under controlled temperatures and pressures

A device for synthesising and studying compounds under controlled temperatures and pressures includes: a body delimiting a vacuum chamber including temperature-regulation means and vacuum-application means, and having one or more viewing windows enabling the inside of the chamber to be observed from the outside; temperature-regulation means that are intended for... Centre National De La Recherche Scientifique cnrs

10/26/17 / #20170306011

Monoclonal antibodies to progastrin and their uses

The present disclosure is directed to progastrin monoclonal antibodies, fragments thereof, compositions comprising progastrin monoclonal antibodies, and methods of making and using progastrin monoclonal antibodies and compositions thereof. The present disclosure is directed to methods of treating colorectal cancer with progastrin monoclonal antibodies and compositions comprising progastrin monoclonal antibodies or... Centre National De La Recherche Scientifique cnrs

10/26/17 / #20170306012

Monoclonal antibodies to progastrin and their uses

The present disclosure is directed to progastrin monoclonal antibodies, fragments thereof, compositions comprising progastrin monoclonal antibodies, and methods of making and using progastrin monoclonal antibodies and compositions thereof. The present disclosure is directed to methods of treating colorectal cancer with progastrin monoclonal antibodies and compositions comprising progastrin monoclonal antibodies or... Centre National De La Recherche Scientifique cnrs

10/26/17 / #20170309497

Method for manufacturing a resistive device for a memory or logic circuit

A method for manufacturing a resistive device, includes depositing a first electrically conductive layer on a substrate; forming an etching mask on the first conductive layer; etching the first conductive layer through the mask, such as to obtain a plurality of electrically conductive pillars separated from one another; and forming... Centre National De La Recherche Scientifique cnrs

10/19/17 / #20170296547

Dermocosmetic or pharmaceutical use of a composition comprising at least one inhibitor of some chemoattractant cytokines

The present invention relates to the cosmetic or pharmaceutical use for a composition comprising a salicylic or nicotinic acid derivative inhibiting chemokines, for preventing or treating chronic internal and/or external inflammatory conditions.... Centre National De La Recherche Scientifique cnrs

10/19/17 / #20170298351

Method for screening interfering molecules

A method for screening interfering nucleic acids enhancing the expression or the activity of expressed gene sequences is described. The method includes a step of introducing, into a cell, a hybrid nucleic acid molecule having: a first non-coding sequence intended to initiate translation; a second sequence complementary to the interfering... Centre National De La Recherche Scientifique cnrs

10/19/17 / #20170298408

Automated analyzing and interpreting an antimicrobial susceptibility

The present invention relates to a method of interpreting different antibiogram images in which it is possible to recognize a phenotype of bacterial resistance relative to antibiotics by comparing photographs using a photographic image bank of the reference antibiogram without any need to interpret them using the EUCAST or CA-SFM... Centre National De La Recherche Scientifique cnrs

10/19/17 / #20170299514

Non-destructive detection charged particles without mass limitation

A non-destructive method for detecting charged particles, includes measuring a reference value of at least one physical parameter of an ion cloud confined in an ion trap; performing an injection of a sample in the ion cloud confined in the ion trap, the sample crossing the ion cloud and getting... Centre National De La Recherche Scientifique cnrs

10/05/17 / #20170281653

Dermocosmetic or pharmaceutical use of a composition containing at least one inhibitor of certain chemokines

The present invention relates to the cosmetic or pharmaceutical use for a composition comprising a salicylic or nicotinic acid derivative inhibiting chemokines, for preventing or treating chronic internal and/or external inflammatory conditions.... Centre National De La Recherche Scientifique cnrs

10/05/17 / #20170284961

Microfluidic analysis device and method

The present invention relates to a microfluidic analysis device (1) including: a substrate (20) wherein a separation channel (10) is arranged, in which an electrolyte flows, a portion of the separation channel (10) being covered with a polarisable surface (11); two longitudinal field electrodes (8a, 8b) arranged on either side... Centre National De La Recherche Scientifique cnrs

Patent Packs
09/28/17 / #20170275216

Process for the specific isotopic labeling of methyl groups of val, leu and ile

A process for the specific isotopic labeling of an amino acid selected from Valine (Val), Leucine (Leu), and Isoleucine (Ile), in proteins and biomolecular assemblies by introducing, in a medium containing bacteria overexpressing a protein, an acetolactate derivative of Formula I of the application.... Centre National De La Recherche Scientifique cnrs

09/07/17 / #20170253610

Nitrogen-containing analogs of salinomycin, synthesis and use against cancer stem cells and malaria

The present invention concerns compounds of formula (I), enantiomers, mixture of enantiomers, diastereoisomers and mixture of diasteroisomers thereof formula (I): wherein at least one of W, X and Y is selected from the group consisting of —NR1R2; —NR3—(CH2)n—NR4R5; —O—(CH2)n—NR4R5; —NR3—(CH2)n—N′R6R7R8; and —O—(CH2)n—N′R6R7R8 and Z is a functional group capable of... Centre National De La Recherche Scientifique cnrs

08/31/17 / #20170246631

Microfluidic device with one microchannel for multiple detection

The present invention relates to a microfluidic device (2) comprising a support part (21) and a cover part (22) defining together a microchannel (5), said microchannel (5) having a surface, said surface comprising:—a first area (9) which is grafted with a first ligand, and—at least a second area (10) which... Centre National De La Recherche Scientifique cnrs

08/24/17 / #20170239242

Methods and pharmaceutical compositions for the treatment of fibrosis

The present invention relates to methods and pharmaceutical compositions for the treatment of fibrosis. In particular, the present invention relates to a method of treating fibrosis in a subject in need thereof comprising administering the subject with a therapeutically effective amount of at least one monoacylglycerol lipase (MGL) inhibitor.... Centre National De La Recherche Scientifique cnrs

08/24/17 / #20170240869

Clostridium acetobutylicum strains unable to produce hydrogen and useful for the continuous production of chemicals and fuels

The present invention relates to a new strain of Clostridium acetobutylicum modified to be unable to produce hydrogen and its use for the continuous production of bulk chemicals such as lactate, 1,3-propanediol, ethanol, butanol, isobutanol, 1,3-butanediol, acetate, acetone, isopropanol, 3-hydroxy-3-methylbutyrate and isobutene at high yield.... Centre National De La Recherche Scientifique cnrs

08/24/17 / #20170242232

Method for analyzing a sample with a non-linear microscopy technique and non-linear microscope associated

The present invention concerns a method for generating a pattern of light, this method comprising the following steps: a) emitting an input laser pulse (P1), b) deflecting the input laser pulse (P1) by a first deflector (22) to obtain a first laser pulse, c) deflecting the first laser pulse (P3)... Centre National De La Recherche Scientifique cnrs

08/24/17 / #20170245059

Electroacoustic transducer, and associated assembly and system

Disclosed is an acoustic transducer for converting a sound signal into an electric signal, including a mobile element movable under the effect of the sound signal, a fixed element opposite the mobile element, a recess, and a dissipative element between the mobile and fixed elements. The coupled system has a... Centre National De La Recherche Scientifique cnrs

08/17/17 / #20170233354

Flt3 receptor antagonists

The invention pertains to novel FLT3 receptor antagonists of general formula (1). The compounds are useful for the treatment or the prevention of pain disorders, cancer and autoimmune diseases.... Centre National De La Recherche Scientifique cnrs

08/17/17 / #20170233469

Prophylaxis of colorectal and gastrointestinal cancer

The present disclosure provides methods and compositions useful for preventing gastrointestinal and/or colorectal cancer in animals, including humans, having pre-cancerous adenomatous polyps. The present disclosure provides compositions comprising anti-PG antibodies suitable for use in the methods of the disclosure. The present disclosure also provides methods and compositions useful for monitoring... Centre National De La Recherche Scientifique cnrs

08/03/17 / #20170217014

Modular robotic finger for grasping and dexterous handling

The invention concerns a device forming a robotic finger comprising a base (100) forming a palm, at least one knuckle (500, 700, 900) articulated on the base (100) about two separate joints (200, 400) non-parallel to each other, at least two actuators (110, 120, 130, 140) and cable-linking means (112,... Centre National De La Recherche Scientifique cnrs

08/03/17 / #20170217832

Transparent substrate, in particular a glass substrate, coated with at least bifunctional porous layer, manufacturing method and uses thereof

A transparent glass or ceramic or glass-ceramic substrate, coated with a functional layer or with a stack of at least two functional layers, the functional layer or at least one of the functional layers of the stack being porous and made of an inorganic material M1, wherein the or at... Centre National De La Recherche Scientifique cnrs

07/27/17 / #20170211151
07/27/17 / #20170209488

Methods for treating neuromuscular junction-related diseases

The present invention relates to methods for treating neuromuscular junction-related diseases. In particular, the present invention relates to a method of treating a neuromuscular junction-related disease in a subject in need thereof comprising ad ministering the subject with a therapeutically effective amount of at least one inhibitor of glycogen synthase... Centre National De La Recherche Scientifique cnrs

07/27/17 / #20170211119

In vivo production of a recombinant carotenoid-protein complex

The present invention relates to a method for producing a carotenoid-protein complex in vivo comprising the steps of transforming of prokaryote cell with genes involved in carotenoid synthesis and with a gene encoding an apo-carotenoprotein; culturing said prokaryote cells such as to induce sequential genes expression, isolating and purifying the... Centre National De La Recherche Scientifique cnrs

07/20/17 / #20170202367

Device for assisting the crawling of an infant

Device for assisting crawling of an infant (2) on a training surface comprising: —a platform (1) comprising a chest supporting surface for supporting a chest of the infant (2) resting on the platform (1) in a prone position, and —rolling elements (9) rotatably mounted on the platform in such a... Centre National De La Recherche Scientifique cnrs

07/06/17 / #20170191059

Nucleic acids acting as decoys for the treatment of lentivirus infection

The present invention relates to nucleic acid sequences which are fragments of HIV-1 genome. The nucleic acids of the present invention are use as decoys for the treatment of lentivirus infection. In particular, the present invention relates to nucleic acids capable of forming at least one G-quadruplex domain and that... Centre National De La Recherche Scientifique cnrs

07/06/17 / #20170191084

Method for producing methane by means of aerobic co-culture of anaerobic micro-organisms

The present invention relates to the biological production of methane (Biogas) by co-culture in an aerobic atmosphere of a methanogenic bacterium and of an anaerobic bacterium capable of producing hydrogen, in a culture medium comprising or being supplemented with carbohydrate compound(s), notably starch and/or sugars, and supplemented with antioxidant compound(s).... Centre National De La Recherche Scientifique cnrs

06/29/17 / #20170182077

Methods and pharmaceutical compositions for the treatment of acute exacerbations of chronic obstructive pulmonary disease

The present invention relates to methods and pharmaceutical compositions for the treatment of acute exacerbation of chronic obstructive pulmonary disease. In particular, the present invention relates to a method of treating acute exacerbation of chronic obstructive pulmonary disease in a subject in need thereof comprising administering the subject with a... Centre National De La Recherche Scientifique cnrs

06/29/17 / #20170183306

Cyclic compounds having a 1,3 diamino-functionality for use in the treatment of hiv infection

The present invention relates to compounds, capable of activating HIV expression in reservoir cells, of formula (I) for use in the treatment of HIV infection.... Centre National De La Recherche Scientifique cnrs

06/29/17 / #20170183620

Use of uric acid for culturing bacteria sensitive to oxygen tension

The present invention relates to a method for cultivating in vitro in an acellular culture medium, bacteria for which the growth is sensitive to oxygen content, said bacterium being selected from anaerobic bacteria and intracellular micro-aerophilic bacteria, characterized in that uric acid is added into said acellular culture medium, and... Centre National De La Recherche Scientifique cnrs

06/29/17 / #20170184566

Methods for determining whether a patient will achieve a response after radiation therapy

Disclosed are methods for determining whether a patient will achieve a response after radiation therapy, in particular a method for determining whether a patient suffering from a cancer will achieve a response after radiation therapy including the steps of i) determining the level of ceramide in a first blood sample... Centre National De La Recherche Scientifique cnrs








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