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Children s Hospital Medical Center
Children s Hospital Medical Center Of Akron
Children s Hospital Medical Center D b a Cincinnati Children s Hospital Medical Center
Children s Hospital Medical Center And Spineform Llc

Children s Hospital Medical Center patents


Recent patent applications related to Children s Hospital Medical Center. Children s Hospital Medical Center is listed as an Agent/Assignee. Note: Children s Hospital Medical Center may have other listings under different names/spellings. We're not affiliated with Children s Hospital Medical Center, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "C" | Children s Hospital Medical Center-related inventors


 new patent  Methods and compositions for treatment of venous malformation

Methods of treating venous malformation (VM) are described. The described methods may include the steps of administering an mTOR inhibitor and an ABL kinase inhibitor to an individual in need thereof. Articles of manufacture comprising a container and a composition comprising the actives used in the disclosed methods are also... Children s Hospital Medical Center

 new patent  Treatment of disease via transcription factor modulation

Disclosed herein are methods of treatment of various disease states in which an individual in need thereof if administered one or more therapeutic agents capable of modulating one or more transcription factors. Also disclosed are methods by which an individual may be treated for one or more disease states, in... Children s Hospital Medical Center

Compositions and methods for treatment of lung disorders characterized by cholesterol dysregulation

Disclosed are compositions and methods for treating a condition characterized by a dysregulation in macrophage lipid homeostasis. The disclosed methods may include the administration of an agent selected from a PPARγ agonist, a LXR agonist, or a combination thereof. In certain aspects, the disclosed methods may be used to prevent,... Children s Hospital Medical Center

Spheric endo-luminal traction device for esophageal elongation

Methods and apparatuses for applying tensile force to one or more tissue regions within a body. Illustratively, an implant ball including a spherical side wall is received within a tubular organ, and tensile sutures extend through the implant ball for applying a tensile force to facilitate elongation of the tubular... Children s Hospital Medical Center

Methods and systems for converting precursor cells into intestinal tissues through directed differentiation

The generation of complex organ tissues from human embryonic and pluripotent stem cells (PSCs) remains a major challenge for translational studies. It is shown that PSCs can be directed to differentiate into intestinal tissue in vitro by modulating the combinatorial activities of several signaling pathways in a step-wise fashion, effectively... Children s Hospital Medical Center

Small- molecule inhibitors targeting g-protein-coupled rho guanine nucleotide exchange factors

Provided are inhibitors of Rho GTPase activation, and, in particular, compounds that inhibit RhoA activation by an RhoGEF. Also provided are related pharmaceutical compositions and methods. Also provided are methods of inhibiting Rho GTPase activation. Also provided are methods of screening for compounds that inhibit Rho GTPase activation by a... Children s Hospital Medical Center

Use of small molecule inhibitors targeting eya tyrosine phosphatase

Inhibitors of EYA tyrosine phosphatase are provided herein, as well as pharmaceutical compositions and methods relating thereto.... Children s Hospital Medical Center

Novel pharmacological therapy for neuromuscular contractures

Disclosed are compositions and methods for treatment of an individual having a muscle contracture. The method may include the step of administering nandrolone or a pharmaceutically acceptable salt thereof to the individual in need thereof. The muscle contracture may result from a disorder selected from neonatal brachial plexus injury, cerebral... Children s Hospital Medical Center

Optimization of determinants for successful genetic correction of diseases, mediated by hematopoietic stem cells

Methods and compositions disclosed herein generally relates to methods of determining minimum hematopoietic stem cell (HSC) chimerism and gene dosage for correction of a hematopoietic disease; in particular, in in vivo models. The invention also relates to modified lentiviral expression vectors for increase a viral titer and various methods for... Children s Hospital Medical Center

Novel pharmacological therapy for neuronopathic gaucher disease

The instant disclosure relates to methods and compositions for the treatment of Gaucher disease, particularly type II and III neuronopathic Gaucher disease (nGD). The methods include the step of administering to an individual in need thereof an effective amount of a ryanodine receptor inhibitor or a pharmaceutically acceptable salt thereof.... Children s Hospital Medical Center

Lipid hydrolysis therapy for atherosclerosis and related diseases

The present invention comprises a method to diminish and/or eliminate atherosclerotic plaques, in mammals, through direct and indirect treatment of these plaques, in situ, using suitable substances which are capable of lipid removal, primarily through hydrolysis, either by a catalytic or stoichiometric process, wherein the substance targets receptors in and/or... Children s Hospital Medical Center

In vivo model of human small intestine using pluripotent stem cells and methods of making and using same

Disclosed are methods for making a vascularized hollow organ derived from human intestinal organoid (HIOs). The HIOs may be obtained from human embryonic stem cells (ESC's) and/or induced pluripotent stem cells (iPSCs), such that the HIO forms mature intestinal tissue. Also disclosed are methods for making a human intestinal tissue... Children s Hospital Medical Center

Methods and compositions for treating conditions associated with spinal cord injury

In one aspect, a method of treating a condition associated with spinal cord injury is disclosed, wherein an agent that inhibits excitatory neurons and/or activates inhibitory interneurons may be administered to an individual in need thereof. Articles of manufacture and kits related to the disclosed methods are also disclosed.... Children s Hospital Medical Center

Methods and systems for converting precursor cells into gastric tissues through directed differentiation

Disclosed are methods of inducing formation of a gastric cells and/or a gastric tissue, such as in the form of a gastric organoid. The formation of gastric cells and/or tissue may be carried out by the activating and/or inhibiting of one or more signaling pathways within a precursor cell. Also... Children s Hospital Medical Center

Diagnostic distinguishing forms of esophageal eosinophilia

The invention provides methods for diagnosing eosinophilic esophagitis in a patient using a biomarker based assay directed to KCNJ2/Kir2.1 and related compositions, kits, and computer program products.... Children s Hospital Medical Center

Methods for diagnosing and treating eosinophilic esophagitis

Disclosed are methods of diagnosing and treating a subject with active or inactive eosinophilic esophagitis (EoE). The methods may include the steps of detecting whether a level of eosinophil lineage-committed progenitor (EoP) is elevated in a blood sample obtained from a subject, diagnosing the subject with active EoE when an... Children s Hospital Medical Center

Image guided autonomous needle insertion device for vascular access

An image guided autonomous needle insertion device including a delivery system, a path planner, an image processor, and a human machine interface. The system also includes an ultrasound probe in communication with a frame grabber, a percutaneous insertion device, and at least a first actuator for moving the percutaneous insertion... Children s Hospital Medical Center

Genetic test for determining susceptibility for eosinophilic esophagitis

Methods and compositions disclosed herein generally relate to determination of susceptibility to eosinophilic esophagitis, asthma, and/or allergic diseases, disorders, and/or pulmonary and/or upper gastrointestinal conditions arising therefrom and/or related thereto and the diagnosis, treatment, and/or management of eosinophilic esophagitis, asthma, and/or allergic diseases, disorders, and/or pulmonary and/or upper gastrointestinal conditions... Children s Hospital Medical Center

Compositions and methods for treatment of pediatric pain

Disclosed are methods of treating pain in a mammal, which may include the step of administering human growth hormone to a mammal in need thereof. The pain treated by the disclosed methods may be of a type caused by inflammation induced mechanical and/or thermal hypersensitivity, and may include, for example,... Children s Hospital Medical Center

Lipid hydrolysis therapy for atherosclerosis and related diseases

The present invention comprises a method to diminish and/or eliminate atherosclerotic plaques, in mammals, through direct and indirect treatment of these plaques, in situ, using suitable substances which are capable of lipid removal, primarily through hydrolysis, either by a catalytic or stoichiometric process, wherein the substance targets receptors in and/or... Children s Hospital Medical Center

An improved fetal hemoglobin for genetic correction of sickle cell disease

Methods and compositions disclosed herein generally relates to methods of determining minimum hematopoietic stem cell (HSC) chimerism and gene dosage for correction of a hematopoietic disease; in particular, in in vivo models. The invention also relates to modified lentiviral expression vectors for increasing a viral titer and various methods for... Children s Hospital Medical Center

Optimization and individualization of medication selection and dosing

Described are methods for treating a patient with a therapeutic drug using a combination of genetic and non-genetic information to tailor the dose of the drug to the patient.... Children s Hospital Medical Center

Surfactant protein d for the treatment of disorders associated with lung injury

Surfactant protein D (SP-D) is a member of the collectin family of collagenous lectin domain-containing proteins that is expressed in epithelial cells of the lung. Described herein are methods and compositions for the treatment of disorders associated with lung injury, including methods and compositions for the treatment of bronchopulmonary disorder... Children s Hospital Medical Center

Lysosomal protein targeting sequence and therapeutic applications of same

The present disclosure relates to methods of treating diseases states such as lysosomal storage diseases and/or neurodegenerative diseases. Also disclosed are one or more compositions that may be useful for one or more of the disclosed methods, including compositions that may comprise acid β-glucosidase (GCase) protein comprising one or more... Children s Hospital Medical Center

Compositions and methods for treatment of lung dysfunction

Described are compositions and methods for the treatment, prevention, or amelioration of a symptom of an airway disorder. In certain aspects, the airway disorder may be one characterized by one or more conditions, such as goblet cell metaplasia, lung tissue inflammation, increased airway hyperresponsiveness, mucus hyperplasia, decreased airway resistance, and... Children s Hospital Medical Center

Genomic instability markers in fanconi anemia

Markers for genomic instability in Fanconi Anemia (FA) and other pathologies for therapeutic and diagnostic uses. In one embodiment, glycosphingolipid metabolism is altered in the FA deficient squamous cell carcinoma (SCC) cells, based on analysis of a metabolomics/lipidomics platform. The data indicated ganglioside metabolism was important in FA patients' susceptibility... Children s Hospital Medical Center

Compositions and methods for treating an autism spectrum disorder

Disclosed are compositions and methods for the treatment of a subject having an autism spectrum disorder. The disclosed compositions may contain racemic ketamine or S-ketamine. The disclosed methods of administering the compositions include intranasal administration to a subject having an autism spectrum disorder.... Children s Hospital Medical Center

Combination therapy for mds

Disclosed are compositions and methods for the treatment of disorders such as myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). The disclosed methods include administering to an individual in need of such treatment a composition that may include an IRAK1/4 inhibitor. In other aspects, the method may include administration of... Children s Hospital Medical Center

Therapy for solid tumors

A pharmaceutically acceptable composition and method for solid tumor therapy in a patient in need of such therapy. The composition contains, as the only active agents, the combination of (a) an inhibitor of c-Fos, and (b) an inhibitor of Dusp-1, and optionally (c) an inhibitor of a tyrosine kinase. The... Children s Hospital Medical Center

Evaluation of eosinophilic esophagitis

A method to evaluate eosinophilic esophagitis based on information in an eosinophilic esophagitis transcriptome.... Children s Hospital Medical Center

Methods and compositions for personalized pain management

The invention provides methods, kits and systems related to personalized pain management.... Children s Hospital Medical Center

Processing text with domain-specific spreading activation methods

A method for performing natural language processing of free text using domain-specific spreading activation. Embodiments of the present invention ontologize free text using an algorithm based on neurocognitive theory by simulating human recognition, semantic, and episodic memory approaches. Embodiments of the invention may be used to process clinical text for... Children s Hospital Medical Center

Ngal for diagnosis of renal conditions

Use of serum neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker, alone or in conjunction with creatinine to aid in the diagnosis of renal conditions such as acute tubular necrosis and acute renal failure, and a method and a kit for assigning a diagnosis of acute tubular necrosis or acute renal... Children s Hospital Medical Center

Methods for assessing responsiveness to asthma treatment based on vnn-1 expression and promoter methylation

Provided herein are methods and kits related to use of vanin-1 (VNN1) expression for assessing responsiveness to steroid treatment in subjects with asthma and for treating subjects with asthma.... Children s Hospital Medical Center

Methods for assessing responsiveness to asthma treatment based on vnn-1 expression and promoter methylation

Provided herein are methods and kits related to use of vanin-1 (VNN1) expression for assessing responsiveness to steroid treatment in subjects with asthma and for treating subjects with asthma.... Children s Hospital Medical Center








ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009



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