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Children s Medical Center Corporation
Children s Medical Center Corporation Inc
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Children s Medical Center Corporation Massachusett S

Children s Medical Center Corporation patents


Recent patent applications related to Children s Medical Center Corporation. Children s Medical Center Corporation is listed as an Agent/Assignee. Note: Children s Medical Center Corporation may have other listings under different names/spellings. We're not affiliated with Children s Medical Center Corporation, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "C" | Children s Medical Center Corporation-related inventors


Co-activation of mtor and stat3 pathways to promote neuronal survival and regeneration

Disclosed herein is a method of promoting sustained survival, sustained regeneration, in a lesioned mature neuron, sustained compensatory outgrowth in a neuron, or combinations thereof. The method comprises contacting the lesioned mature neuron with an effective amount of an inhibitor of PTEN and an effective amount of an inhibitor of... Children s Medical Center Corporation

Nucleic acid-based linkers for detecting and measuring interactions

The invention provides compositions comprising nucleic acid complexes for use in monitoring binding interactions and in measuring association and/or dissociation kinetics, detecting analytes including low concentration analytes, and screening library members. In some instances, the nucleic acid complexes are double-stranded nicked nucleic acids comprising a scaffold nucleic acid hybridized to... Children s Medical Center Corporation

Methods of membrane-based proteomic sample preparation

A method for rapid isolation of a biological compound (e.g. protein) from an aqueous sample is described herein. The method uses a porous hydrophobic membrane that has an average pore size significantly greater than the size of the biological compound. The method permits the biological compound to attach to the... Children s Medical Center Corporation

Modulation of sh2b3 to improve red blood cell production from stem cells and/or progenitor cells

Disclosed herein are methods for producing red blood cells (RBCs) from a population of stem cells and/or progenitor cells. In at least one of the stem cells or progenitor cells, SH2B3 protein activity is decreased, SH2B3 mRNA level is decreased, and/or SH2B3 protein level is decreased. The methods provided herein... Children s Medical Center Corporation

Organ mimic device with microchannels and methods of use and manufacturing thereof

System and method includes a body having a central microchannel separated by one or more porous membranes. The membranes are configured to divide the central microchannel into a two or more parallel central microchannels, wherein one or more first fluids are applied through the first central microchannel and one or... Children s Medical Center Corporation

Collagen scaffolds

Methods for preparing and using collagen extracts and collagen scaffolds are provided. Additionally methods and related kits for the repair of articular tissue using the collagen material are provided.... Children s Medical Center Corporation

Natural igm antibodies and inhibitors thereof

The invention provides natural IgM antibody inhibitors that may be used to treat various inflammatory diseases or disorders.... Children s Medical Center Corporation

Methods for enhancing hematopoietic stem/progenitor cell engraftment

Described herein are methods for enhancing engraftment of hematopoietic stem and progenitor cells using farnesyl compounds identified using a zebrafish model of hematopoietic cell engraftment. The compounds can be used to treat hematopoietic stem cells ex vivo prior to transplantation of the cells. Alternatively, the compounds can be administered to... Children s Medical Center Corporation

Methods and compositions to increase somatic cell nuclear transfer (scnt) efficiency by removing histone h3-lysine trimethylation

The present invention provides methods and compostions to improve the efficiency of somatic cell nuclear transfer (SCNT) and the consequent production of nuclear transfer ESC (ntESC) and transgenic cells and/or non-human animals. More specifically, the present invention relates to the discovery that trimethylation of Histone H3-Lysine 9 (H3K9me3) in reprogramming... Children s Medical Center Corporation

Inhibition and enhancement of reprogramming by chromatin modifying enzymes

In one aspect, the disclosure provides methods and compositions for the production of stem cells. In one aspect, the disclosure provides methods and uses of stem cells. In some embodiments, the stem cells are induced pluripotent stem cells.... Children s Medical Center Corporation

Origami robots, systems, and methods of treatment

Origami robots, and associated systems, methods of treatment, and methods of manufacture are provided. A system includes an origami robot encapsulated for ingestion by a patient, such as in a biocompatible material that is dissolvable or meltable within the gastrointestinal tract. A method of treatment includes delivering an origami robot... Children s Medical Center Corporation

Dietary emulsion formulations and methods for using the same

Disclosed herein is a formulation that can take the form of an emulsion which contains total enteral or parenteral nutrition for a recipient subject. The formulation includes as the sole fat components: (i) medium chain triglycerides; and (ii) very long chain fatty acids selected from (a) very long chain omega-3... Children s Medical Center Corporation

Methods and assays relating to sepiapterin reductase inhibition

Described herein are methods and assays relating to the inhibition of sepiapterin reductase and measuring said inhibition by measuring the level of sepiapterin. In some embodiments, the methods can further relate to treating a subject with BH4 and/or BH2.... Children s Medical Center Corporation

Capillary refill time diagnostic apparatus and methods

An apparatus for measuring capillary refill time has a measurement module containing at least two radiation sources and at least one detector configured to detect radiation from each source that interacts with and is received from a measurement region of a patient or subject. One radiation source may be characterized... Children s Medical Center Corporation

Biochemically stabilized hiv-1 env trimer vaccine

Stabilized trimers of a clade A strain and a clade C strain of HIV-1 are provided. Broadly neutralizing antisera against HIV-1, methods of making broadly neutralizing antisera against HIV-1, broadly neutralizing vaccines against HIV-1, as well as methods of treating subjects infected with HIV, preventing HIV infection, and inhibiting HIV-mediated... Children s Medical Center Corporation

Non-invasive enzyme screen for tissue remodelling-associated conditions

Methods and kits for diagnosing the presence of and prognosing the appearance of tissue remodelling-associated conditions, involving the presence of enzyme complexes in a biological sample, are disclosed. In particular, the method pertains to diagnosing the presence of or prognosing appearance of metastatic cancer by the identification of high molecular... Children s Medical Center Corporation

Multielectrode ecg sensor

A multielectrode sensor for use in obtaining electrocardiograph measurements of a patient is disclosed. The sensor includes a substrate, at least a portion of the substrate being stretchable, and a plurality of electrodes coupled to the substrate. A distance between at least two of the electrodes is adjustable by stretching... Children s Medical Center Corporation

Combined tweezers and using combined tweezers

Disclosed is a medical device that is capable of grasping multiple sites of one object or multiple objects simultaneously. The medical device includes a platform and a plurality of pincer sets that are attached to the platform. The plurality of pincer sets extend from the platform at varied lengths and... Children s Medical Center Corporation

Methods to treat neurodegenerative diseases

The specification provides compositions and methods to treat neurodegenerative diseases.... Children s Medical Center Corporation

Apparatuses for cleaning catheter ports

Methods and apparatus for cleaning a central venous catheter port are disclosed. An apparatus includes a body, a coupling configured to connect the body to the hub, a cleaning cap coupled to the body, and an actuator disposed within the body for rotating and translating the cap relative to the... Children s Medical Center Corporation

Methods and compositions for the treatment of cancer

Described herein are methods and compositions relating to the treatment of cancer, e.g., breast cancer, using, e.g., aptamer-siRNA chimera molecules.... Children s Medical Center Corporation

Methods and compositions relating to exosomes

The disclosure provides compositions comprising exosome subpopulations, and methods of their use in subjects having certain disorders including lung disorders, cardiovascular disorders, renal disorders and ischemic neural disorders. The disclosure provides compositions comprising exosomes and methods of use thereof in the treatment and/or prevention of various diseases or disorders. 25... Children s Medical Center Corporation

Instrument port with integrated imaging system

An instrument port for introducing an instrument into a surgical site includes a port body, a bulb disposed on the distal end of the port body, and a channel extending from a proximal end to a distal end of the instrument port. The channel includes an instrument channel defined in... Children s Medical Center Corporation

Computer aided mechanical ventilation systems and methods

In one embodiment, a method for categorizing a state of a subject undergoing therapy from a mechanical ventilator is disclosed. The method includes receiving, at a device, one or more cardiovascular measurements regarding the subject, a respiratory rate from the ventilator, a carbon dioxide (CO2) measurement regarding the subject, and... Children s Medical Center Corporation

Compositions and methods of treating muscular dystrophy

Provided herein are compositions and methods of treating muscular dystrophy (MD), such as administering an effective amount of a composition that increases the expression of JAG1, a composition comprising a JAG1 agonist, or a composition that promotes JAG1 signaling. Also provided are methods of prognosing MD or evaluating responsiveness to... Children s Medical Center Corporation

Vaccine adjuvant compositions

Embodiments described herein relate to combinatorial compositions and uses thereof, for example, as vaccine adjuvant compositions, for enhancing immune response, for inducing differentiation of nave T cells to differentiate into IFN-γ-producing T cells, and for preventing and treating infections. The combinatorial composition comprises TLR and CLR agonists. The combinatorial composition... Children s Medical Center Corporation

Compositions and methods to treating hemoglobinopathies

Embodiment herein provide specially designed synthetic BCL11A-targeting microRNAs for RNA polymerase II expression, and methods o use to treat hemoglobinopathies such as sickle cell disease or thalassemia by increasing the expression levels of fetal hemoglobin levels. In particular illustrative embodiment, the present invention provides, in part, improved compositions and methods... Children s Medical Center Corporation

Cyr61 as a biomarker for diagnosis and prognosis of cancers of epithelial origin

Urinary Cyr61 protein levels are up regulated in patients that have cancers of epithelial origin, i.e. breast cancer and ovarian cancer. Accordingly, the present invention is directed to methods for prognostic evaluation, and diagnosis of cancers of epithelial origin. Further, the amount of Cyr61 protein detected in a urine sample... Children s Medical Center Corporation

Methods for treating and preventing neutrophil-derived net toxicity and thrombosis

Embodiments of the technology described herein are based upon the discoveries that neutrophil extracellular traps (NETs) provide a stimulus for thrombus formation and that NETs are present in stored blood products. Accordingly, some embodiments relate to methods of treating and preventing toxicity of NETs and thrombosis caused by NETs. Additional... Children s Medical Center Corporation

Antibody molecules to tim-3 and uses thereof

Antibody molecules that specifically bind to TIM-3 are disclosed. The anti-TIM-3 antibody molecules can be used to treat, prevent and/or diagnose immune, cancerous, or infectious conditions and/or disorders.... Children s Medical Center Corporation

Treatment and prevention of liver disease associated with parenteral nutrition (pn)

The present invention is based on the discovery that parenteral nutrition (PN) induced liver disease, e.g. fatty liver disease, can be prevented and even reversed by administration of primarily omega-3-fatty acid with PN rather than the administration of the standard intravenous lipid emulsions that contain primarily plant derived omega-6 fatty... Children s Medical Center Corporation

Antibody molecules to tim-3 and uses thereof

Antibody molecules that specifically bind to TIM-3 are disclosed. The anti-TIM-3 antibody molecules can be used to treat, prevent and/or diagnose immune, cancerous, or infectious conditions and/or disorders.... Children s Medical Center Corporation

Selective oxidation of 5-methylcytosine by tet-family proteins

The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TET3, and CXXC4. The novel activity is related to the enzymes... Children s Medical Center Corporation

Methods for diagnosis and prognosis of cancer

We have discovered a protein in humans, herein referred to as collagen like gene (CLG) product (SEQ ID NOS: 12 and 13), that is expressed in human prostate cancer and breast cancer cell lines but not in normal adult, placenta, lung, liver, skeletal muscle, kidney or pancreas tissues. We have... Children s Medical Center Corporation

06/22/17 / #20170173005

Method for detecting or treating triple negative breast cancer

A method of detecting triple negative breast cancer (TNBC) is provided. Overexpression of ICAM-1 is linked to an increased risk of TNBC. A composition of matter is also provided that binds an anti-ICAM˜1 antibody to a nanoparticle. The composition may be used as an imaging agent and/or a therapeutic targeting... Children s Medical Center Corporation

06/22/17 / #20170173109

Cyclic prosaposin peptides and uses thereof

Provided herein are cyclic prosaposin peptides and compositions and uses thereof. Exemplary uses include use in the treatment of cancer or in the treatment of inflammatory diseases or disorders.... Children s Medical Center Corporation

06/22/17 / #20170174787

Tiki inhibitors

Modulators of Wnt activity, e.g., Wnt inhibitors, that act on TIKI proteins and inhibit TIKI-mediated cleavage of Wnt proteins, as well as methods of identifying such modulators and methods of use thereof.... Children s Medical Center Corporation

06/15/17 / #20170164591

Sperm-specific cation channel, catsper2, and uses therefor

Nucleic acid and protein sequences relating to a cation channel which is sperm-specific (CatSper2) are disclosed. The CatSper2 protein is shown to be specifically expressed in sperm. Nucleic acids, vectors, transformed cells, transgenic animals, polypeptides, and antibodies relating to the CatSper2 gene and protein are disclosed. Also provided are methods... Children s Medical Center Corporation

06/08/17 / #20170156854

Curved fiber arrangement for prosthetic heart valves

A leaflet including fibers oriented at an angle relative to at least one free edge of the leaflet. A leaflet including mechanisms for increasing coaptation height, preventing billowing, and reducing stress in critical regions of the leaflet. A prosthetic heart valve, including three leaflets operatively attached together. A method of... Children s Medical Center Corporation

06/08/17 / #20170157234

Vaccines and compositions against streptococcus pneumoniae

Streptococcus pneumoniae is a major health concern, especially in very young, elderly, or immunocompromised patients. The present disclosure provides, inter alia, certain highly effective vaccines and pharmaceutical compositions in Streptococcus pneumoniae. The antigens may be used therapeutically or prophylactically.... Children s Medical Center Corporation

06/01/17 / #20170152513

Modulation of bcl11a for treatment of hemoglobinopathies

The invention relates to methods and uses of modulating fetal hemoglobin expression (HbF) in a hematopoietic progenitor cells via inhibitors of BCL11A expression or activity, such as RNAi and antibodies.... Children s Medical Center Corporation

05/25/17 / #20170145484

Selective oxidation of 5-methylcytosine by tet-family proteins

The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TET3, and CXXC4. The novel activity is related to the enzymes... Children s Medical Center Corporation

05/11/17 / #20170128529

Co-activation of mtor and stat3 pathways to promote neuronal survival and regeneration

Disclosed herein is a method of promoting sustained survival, sustained regeneration, in a lesioned mature neuron, sustained compensatory outgrowth in a neuron, or combinations thereof. The method comprises contacting the lesioned mature neuron with an effective amount of an inhibitor of PTEN and an effective amount of an inhibitor of... Children s Medical Center Corporation

05/04/17 / #20170120237

Products and methods to isolate mitochondria

Filtration apparatuses, kits, and methods for rapid isolation of intact, viable mitochondria from tissues are described with mitochondria isolated by differential filtration through nylon mesh filters. Mitochondria can be isolated in less than 30 minutes using the filtration apparatuses, kits, and methods described.... Children s Medical Center Corporation

04/27/17 / #20170112905

Systemic gene replacement therapy for treatment of x-linked myotubular myopathy (xlmtm)

The present invention provides compositions and methods for treating a myopathy. In certain embodiments, the invention provides compositions and methods for treating, improving muscle function, and prolonging survival in a subject with X-linked myotubular myopathy (XLMTM). The present invention provides a method comprising systemic administration of a composition that induces... Children s Medical Center Corporation

04/20/17 / #20170105647

Systems and methods for identifying neurobiological biomarkers using eeg

A computer implemented method, system and software for detection of a biological condition including instructions for measuring a frequency modulated auditory evoked response of a subject and analyzing the frequency modulated auditory evoked response to detect the presence or absence of the biological condition in the subject. The biological condition... Children s Medical Center Corporation

04/20/17 / #20170105980

Methods for treating nicotinic acetylcholine receptor associated diseases

The present invention provides methods and compositions for treating subjects suffering from a disorder associated with a nicotinic acetylcholine receptor (nAChR), methods for treating a subject having a disorder that would benefit from an increase in neural plasticity, and methods for modulating the plasticity of the primary visual cortex in... Children s Medical Center Corporation

04/20/17 / #20170107269

Sperm-specific cation channel, and uses therefor

Nucleic acid and protein sequences relating to a cation channel which is sperm-specific (CatSper1) are disclosed. The CatSper1 protein is shown to be specifically expressed in sperm and to be necessary for sperm motility. Nucleic acids, vectors, transformed cells, transgenic animals, polypeptides, and antibodies relating to the CatSper1 gene and... Children s Medical Center Corporation

04/13/17 / #20170100456

Methods and compositions for immunomodulation

The methods and uses described herein relate to the modulation of the immune system by modulation of Sema3F levels and/or activity, e.g. suppressing allograft rejection or inflammation by administering a Sema3F agonist or increasing an immune response by administering a Sema3F inhibitor.... Children s Medical Center Corporation

04/06/17 / #20170095540

Systemic gene replacement therapy for treatment of x-linked myotubular myopathy (xlmtm)

The present invention provides compositions and methods for treating a myopathy. In certain embodiments, the invention provides compositions and methods for treating, improving muscle function, and prolonging survival in a subject with X-linked myotubular myopathy (XLMTM). The present invention provides a method comprising systemic administration of a composition that induces... Children s Medical Center Corporation

04/06/17 / #20170095563

Mucosal delivery of therapeutic molecules, proteins, or particles coupled to ceramide lipids

Described herein are compositions and methods useful for allowing for the absorption (passage) of agents of interest, such as therapeutic agents, across epithelial and mucosal barriers and/or into certain subcellular compartments of the cell, such as the recycling endosome (RE), Golgi, and the endoplasmic reticulum (ER).... Children s Medical Center Corporation

04/06/17 / #20170096707

Methods for diagnosing and assessing risk of developing glomerulosclerosis

This document features method related to variants in the Inverted Formin 2 (INF2) gene that are associated with susceptibility to focal segmental glomerulosclerosis (FSGS). For example, methods of using such variants for risk assessment and for diagnosing and optimizing treatment of FSGS are provided.... Children s Medical Center Corporation

03/23/17 / #20170079717

Catheter device for transmitting and reflecting light

An insertable light-dispensing catheter device, comprising a shaft including a proximal and distal end, a light guide extending through the shaft, and a mirror displaceably extendable from the catheter into a position where the mirror receives and reflects light emitted from the light guide. The mirror can be in the... Children s Medical Center Corporation

03/23/17 / #20170082631

Free ngal as a biomarker for cancer

Uncomplexed neutrophil gelatinase associated lipocalin (NGAL) is present at increased levels in individuals with atypical ductal hyperplasia (ADH), a major risk factor for future breast cancer development; in individuals that have ovarian cancer; and in individuals that have breast cancer, both invasive and noninvasive. Accordingly, the present invention is directed... Children s Medical Center Corporation

03/16/17 / #20170072109

Scaffolds comprising nanoelectronic components for cells, tissues, and other applications

The present invention generally relates to nanoscale wires and tissue engineering. In various embodiments, cell scaffolds for growing cells or tissues can be formed that include nanoscale wires that can be connected to electronic circuits extending externally of the cell scaffold. The nanoscale wires may form an integral part of... Children s Medical Center Corporation

03/09/17 / #20170065676

Bpi and its congeners as radiation mitigators and radiation protectors

Described herein is a method of mitigating, in a subject (individual), tissue injury resulting from exposure to radiation (accidental/unintentional or intentional, such as therapeutic), chemoradiotherapy, disease, toxin, or drug or biologic mediated therapy.... Children s Medical Center Corporation

03/02/17 / #20170056471

Bpi and its congeners as radiation mitigators and radiation protectors

Described herein is a method of mitigating, in a subject (individual), tissue injury resulting from exposure to radiation (accidental/unintentional or intentional, such as therapeutic), chemoradiotherapy, disease, toxin, or drug or biologic mediated therapy.... Children s Medical Center Corporation

02/23/17 / #20170049379

Mri characterization of placental oxygen transport

A method is provided for generating images using a MRI system. The method includes one or more acts below. First, the MRI system applies a pulse sequence to obtain a first set of blood oxygenation level dependent (BOLD) MRI images of a pregnant subject during a first time period. The... Children s Medical Center Corporation

02/16/17 / #20170042475

Systems and methods for predicting adverse events and assessing level of sedation during medical procedures

Systems and methods are disclosed herein for quantitatively identifying a patient's sedation level and predicting adverse events, based on one or more capnograms or outputs from a pharmacokinetic, pharmacodynamic, or ventilatory model. A sensor measures a carbon dioxide concentration of air exhaled by a patient into a breath receiver. A... Children s Medical Center Corporation

02/16/17 / #20170044607

High throughput genome-wide translocation sequencing

Provided are methods for high-throughput screening to determine locations of double-stranded DNA breaks (DSBs) and translocations in genomes caused by different agents, such as enzymes.... Children s Medical Center Corporation

02/16/17 / #20170045506

High-throughput structure determination using nucleic acid calipers

Provided herein are compositions and methods for determining the structure of individual targets using nucleic acid caliper by determining long-range distances within such targets.... Children s Medical Center Corporation

02/09/17 / #20170037434

Chromosomal modification involving the induction of double-stranded dna cleavage and homologous recombination at the cleavage site

Methods of modifying, repairing, attenuating and inactivating a gene or other chromosomal DNA in a cell are disclosed. Also disclosed are methods of treating or prophylaxis of a genetic disease in an individual in need thereof. Further disclosed are chimeric restriction endonucleases.... Children s Medical Center Corporation

02/09/17 / #20170037478

Methods for predicting anti-cancer response

The present invention is based, in part, on the identification of novel methods for defining predictive biomarkers of response to anti-cancer drugs.... Children s Medical Center Corporation

02/02/17 / #20170028050

Novel immunogens and methods for discovery and screening thereof

The present application is generally directed to methods for identifying immunogens from organisms and pathogens, and in particular for identifying immunogens which when administered as vaccines elicit a cellular and/or humoral immune response. The present application is also directed to pneumococcal T-cell immunogens, and vaccine compositions comprising one or a... Children s Medical Center Corporation

Patent Packs
01/26/17 / #20170020516

Tissue clip

A tissue clip for adjoining tissues including a body portion, a biasing mechanism interconnecting the body portion to a tissue grasping mechanism, the grasping mechanism having a first condition wherein the grasping mechanism is extending against and away from the body portion and a second condition wherein the grasping mechanism... Children s Medical Center Corporation

01/26/17 / #20170023574

Methods for diagnosis and prognosis of epithelial cancers

The present invention is based on the discovery that three proteins, Cystatin B, Chaperonin 10, and Profilin are present in the urine of patients with bladder cancer, a cancer of epithelial origin. Accordingly, the present invention is directed to methods for prognostic evaluation of cancers of epithelial origin and to... Children s Medical Center Corporation

01/19/17 / #20170014228

Expandable stent valve

An expandable valve (100) and valve frame device that may be implanted within the body, for example, at a position of the heart. The device may be surgically implanted and subsequently expanded at a later time. The device may include an expandable sewing member (160) surrounding the valve frame (130)... Children s Medical Center Corporation

01/12/17 / #20170007196

Automated apparatus to improve image quality in x-ray and associated use

A system or method for improving quality in projection and tomographic x-ray, which includes a depth sensing device to measure a depth of at least one body part of a patient from the depth sensing device and a control unit to calculate a thickness and/or circumference of the body part... Children s Medical Center Corporation

01/05/17 / #20170000935

Mechanical assist device

Methods and apparatuses relate to an implantable device for providing contractile assistance to an organ. The device may include an actuator and anchors located on either side of the actuator. The anchors engage with oppositely positioned tissue walls of an organ chamber, and provide contractile assistance to the organ, repeatedly,... Children s Medical Center Corporation








ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009



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