Corium International Inc patents

Transdermal formulation and delivery low solubility or unstable unionized neutral drugs by in situ salt-to-neutral drug conversion of salt drug

Compositions, devices, and methods for transdermal administration of active agents provided in their salt form instead of neutral form are provided.... Corium International Inc

Transdermal delivery systems with pharmacokinetics bioequivalent to oral delivery

A method for delivering a therapeutic agent to a subject from a transdermal delivery system is described, where the therapeutic agent (i) has a half-life in the blood when delivered orally of greater than about 48 hours and (ii) is for the treatment of a chronic condition. The transdermal delivery... Corium International Inc

Donepezil transdermal delivery system

A transdermal delivery system for systemic delivery of donepezil is described, where the system comprises an adhesive matrix drug reservoir layer comprised of a copolymer of acrylic acid/vinyl acetate, triethyl citrate, and donepezil base generated in situ by reaction of donepezil HCl and an alkaline salt. The system is provided... Corium International Inc

Memantine transdermal delivery systems

Transdermal delivery systems for the systemic delivery of memantine are described, wherein the system comprises a drug reservoir layer and an adhesive layer, optionally together with one or more intermediate and/or supporting layers, wherein the drug reservoir layer comprises an acrylate polymer or copolymer, a permeation enhancer, a carrier, and... Corium International Inc

Transdermal delivery systems with pharmacokinetics bioequivalent to oral delivery

A method for delivering a therapeutic agent to a subject from a transdermal delivery system is described, where the therapeutic agent (i) has a half-life in the blood when delivered orally of greater than about 48 hours and (ii) is for the treatment of a chronic condition. The transdermal delivery... Corium International Inc

Donepezil transdermal delivery system

A transdermal delivery system for systemic delivery of donepezil is described, where the system comprises an adhesive matrix drug reservoir layer comprised of a copolymer of acrylic acid/vinyl acetate, triethyl citrate, and donepezil base generated in situ by reaction of donepezil HCl and an alkaline salt. The system is provided... Corium International Inc

Sodium bicarbonate in situ conversion driven transdermal delivery of amine drug

Compositions, devices, and methods for transdermal administration of active agents provided in their salt form instead of neutral form are provided.... Corium International Inc

Applicators for microneedles

An applicator for a microprojection array is described. In one embodiment, the applicator comprises an energy-storing element. Application of force causes the compressed energy-storing element to extend or transition from first and second configurations, releasing stored energy to deploy a holding member in the application which is configured to hold... Corium International Inc

Method and device for transdermal delivery of parathyroid hormone using a microprojection array

A method and a drug delivery system for transdermally administering parathyroid hormone (PTH) in a pulsatile fashion are provided, where the drug delivery system comprises an array of microprojections each comprising PTH.... Corium International Inc

Hydrogel compositions for tooth whitening

A composition is provided, wherein the composition comprises a water-swellable, waterinsoluble polymer, a blend of a hydrophilic polymer and a complementary oligomer capable of hydrogen bonding to the hydrophilic polymer, and a whitening agent, preferably a peroxide. The composition finds utility as a tooth whitening composition and is applied to... Corium International Inc

Systems and methods for long term transdermal administration

Devices, systems, compositions and methods for long term or prolonged transdermal administration of an active agent are provided.... Corium International Inc

Systems comprising a composite backing and methods for long term transdermal administration

Devices, systems, compositions and methods for long term or prolonged transdermal administration of an active agent are provided.... Corium International Inc

Transdermal administration of tamsulosin

In an aspect of the invention, a composition for making a patch for the transdermal delivery of tamsulosin is provided. The composition comprises (a) at least about 1 wt % tamsulosin or a pharmaceutically acceptable salt of tamsulosin, (b) at least about 40 wt % polyisobutylene adhesive or hydrophobic synthetic... Corium International Inc

Hydrogel compositions for tooth whitening

A composition is provided, wherein the composition comprises a water-swellable, water insoluble polymer, a blend of a hydrophilic polymer and a complementary oligomer capable of hydrogen bonding to the hydrophilic polymer, and a whitening agent, preferably a peroxide. The composition finds utility as a tooth whitening composition and is applied... Corium International Inc