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Coty Inc patents


Recent patent applications related to Coty Inc. Coty Inc is listed as an Agent/Assignee. Note: Coty Inc may have other listings under different names/spellings. We're not affiliated with Coty Inc, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "C" | Coty Inc-related inventors


Radio frequency handpiece for medical treatments

Aspect of the inventions may include a universal handpiece that can be coupled to pre-existing legacy rf signal generator systems to provide certain precision controlled radiofrequency therapies and treatments for skin. Further, another embodiment of the present invention may include an interchangeable electrode (tip section) with an array of distally insulated microneedles, conductive pads or smooth surface configurations which couple to the handpiece for allowing for heating of dermis without damage to the superficial epidermis. ... Coty Inc

Pill-safe

A substance-dispensing device that is programmed by a healthcare provider and whose bulk medication supply is inaccessible to a patient or user at one time. The user will only have access to the dose programmed by the healthcare provider at a specified time and not have access to the internal supply of the medication. ... Coty Inc

Flat pack end table and coffee table

A flat pack table comprises a first straight bar, a second straight bar, a first u-shaped bar, a second u-shaped bar, and a rectangular table top. The flat pack table is arrangeable into a compact state in which the first u-shaped bar and second u-shaped bar are nested around the table top and the straight bars. ... Coty Inc

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Tokusen Kogyo Co., Ltd.

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Antifugetactic agents for the treatment of cancers

This invention provides methods and compositions for modulating movement of eukaryotic cells with migratory capacity. More specifically, the invention provides anti-fugetactic agents and methods for the use thereof in enhancing an immune response.. ... Coty Inc

Methods to treat diseases with protein, peptide, antigen modification and hemopurification

The current invention discloses methods to modify protein and peptide and antigen to treat disease such as pathogen infection, autoimmune diseases and cancer. The method involves increasing the molecular weight of the protein by connecting multiple peptide units with site specific conjugation to extend the in vivo half life. ... Coty Inc

Method of treating proteinuria in pregnancy

A therapeutic agent for the treatment of toxemia, preeclampsia and eclampsia and a method for preparing the therapeutic agent are disclosed. The therapeutic agent is a stable pharmaceutical preparation containing, but not limited to, digestive/pancreatic enzymes. ... Coty Inc

Novel method of treating macular degeneration using botulinum toxin-based pharmaceuticals

Formulations and methods of treatment are disclosed for prevention and/or treatment of visual loss from age-related macular degeneration. The disclosed formulations include botulinum neurotoxin (e.g., botulinum neurotoxin or a fragment thereof, either in pure form or with one or more peptide fragments and/or neurotoxin associated proteins). ... Coty Inc

Adeno-associated virus factor viii vectors

The invention provides improved adeno-associated virus (aav) factor viii (fviii) vectors, including aav fviii vectors that produce a functional factor viii polypeptide and aav fviii vectors with high expression activity.. . ... Coty Inc

Truncated von willebrand factor polypeptides for treating hemophilia

The invention relates to a polypeptide comprising a truncated von willebrand factor (vwf) for use in the treatment of a blood coagulation disorder, wherein the polypeptide carries a half-life extending moiety and is administered in molar excess over factor viii and/or endogenous vwf.. . ... Coty Inc

Novel formulations of pthrp analogue

The present invention provides a non-buffered, neutral ph easily prepared, storage-stable composition containing a parathyroid hormone-related protein (pthrp) analogue and methods of using a pthrp analogue and the pthrp compositions described herein to treat osteoporosis, to increase bone mass or to increase bone quality. The composition has a non-buffered neutral ph which avoids injection site reactions and is easy to prepare and storage stable, in sterile form, and in general may be stored at room temperature for at least several weeks to allow convenient parenteral administration to human patients.. ... Coty Inc

06/14/18 / #20180161400

Antidiabetic oral insulin biguanide combination

Pharmaceutical dosage forms, comprising insulin, a delivery agent that facilitates insulin transport in a therapeutically effective amount to the bloodstream and a biguanide, such as metformin, are disclosed for oral administration to a patient for the treatment of diabetes. Also disclosed are methods for achieving improved glucose tolerance and glycemic control in a diabetic mammal without any statistically significant increase in weight, risk of hypoglycemia or hyperinsulinemia, and the need for monitoring blood glucose concentrations or hba1c levels, and methods for reducing the incidence and/or severity of one or more disease states associated with chronic dosing of insulin; for prophylactically sparing (3-cell function or for preventing (3-cell death or dysfunction in a mammal with impaired glucose tolerance or early stage diabetes mellitus; and for long-term protection from developing (or delaying the onset of) overt or insulin dependent diabetes in a mammal with impaired glucose tolerance or early stage diabetes.. ... Coty Inc

06/14/18 / #20180161398

Composition containing inducer of sirt1 expression for preventing or treating sepsis or septic shock

The present invention relates to a composition containing an inducer of sirt1 (silent mating type information regulation 2 homolog) expression for preventing or treating sepsis or septic shock. The inducer of sirt1 expression can remarkably reduce the mortality caused by sepsis or septic shock by reducing pro-inflammatory cytokines and increasing anti-inflammatory cytokines. ... Coty Inc

06/14/18 / #20180161397

Methods for modulating an inflammatory response

The inventive subject matter relates to novel methods for modulating an immune response in an animal, which comprises administering to said animal an effective amount of an agent that increases il-27r/wsx-1 activity. Further, the inventive subject matter relates to pharmaceutical compositions comprising an effective amount of an agent that increases il-27r/wsx-1 activity.. ... Coty Inc

06/14/18 / #20180161394

Methods and related kits for treating and regenerating tooth pulp and periapical tissues in a mammal

In one embodiment, a method of regenerating tooth pulp in a mammal is provided. The method comprises removing at least a portion the existing tooth pulp of a mammal and adding amelogenin protein to the existing tooth pulp of the mammal to regenerate tooth pulp in a mammal. ... Coty Inc

06/14/18 / #20180161391

Inhibitors of bcl-2

A protease resistant polypeptide includes an amino acid sequence that has a sequence identity at least 80% homologous to about 10 to 80 consecutive amino acids of seq id no:1.. . ... Coty Inc

06/14/18 / #20180161386

Pharmaceutical composition for treatment of depression and preparation method thereof

Disclosed is a pharmaceutical composition for the treatment of depression, wherein the pharmaceutical composition is comprised of the following herbs in weight parts: 2-10 parts ramulus cinnamomi, 2-10 parts rhizoma zingiberis, 2-10 parts fructus schisandrae chinensis, 2-8 parts semen ziziphi spinosae, 2-8 parts radix codonopsis, 1-3 parts rhizoma dioscoreae, 0.5-2.5 parts flos inulae, 1-3 parts caulis bambusae in taenia, 1-3 parts fructus trichosanthis, 1.5-4 parts caulis polygoni multiflori, 1.5-4 parts radix ophiopogonis, 2-8 parts radix rehmanniae, 1.5-4 parts cortex moutan radicis, 0.5-2.5 parts fructus gardeniae, 0.5-2.5 parts herba lophatheri, and 0.2-1.5 parts folium sennae. Also disclosed is a method for preparing the pharmaceutical composition as described above for treatment of depression.. ... Coty Inc

06/14/18 / #20180161385

Compositions and methods for maintaining or enhancing homeostasis or function of female lower reproductive tract

The present disclosure provides compositions and methods for making and using topical compositions comprised of an isotonic, biome-friendly solution containing xylose and/or a salvia extract. The compositions are useful for, for example, maintaining or enhancing female lower reproductive tract (lrt) homeostasis and physiological function. ... Coty Inc

06/14/18 / #20180161383

Natural pharmaceutical composition for treating menopausal mental depression and atypical depressive disorder and application thereof

The present disclosure discloses a pharmaceutical composition for treating menopausal mental depression and atypical depressive disorder and an application thereof. The composition is composed of the following components in percentage by mass: 70%-97.5% of sea buckthorn pulp oil and 2.5%-30% of total panax notoginseng saponins from stem and leave. ... Coty Inc

06/14/18 / #20180161382

Prebiotic compositions comprising one or more types of bacteriophage

Disclosed herein are compositions that comprise one or more types of bacteriophage and methods of using such bacteriophages as a prebiotic to promote the growth of beneficial bacteria by decreasing harmful bacterial populations and releasing nutrients into the environment for good bacteria in the digestive system of an individual.. . ... Coty Inc

06/14/18 / #20180161381

Nutritional compositions and methods for reducing the occurrence or severity of viral infections, bacterial infections and viral and bacterial co-infections

The present disclosure is directed to methods for reducing the risk of developing or reducing the severity of a viral infection, bacterial infection, or viral and bacterial co-infection in a subject comprising administering to the subject a nutritional composition comprising an effective amount of a soluble mediator preparation derived from a late-exponential growth phase of a probiotic culture, such as lactobacillus rhamnosus gg (lgg). The present disclosure, in certain embodiments, is directed to methods for reducing inflammation in a subject with a viral infection, bacterial infection, or viral and bacterial co-infections, comprising administering to the subject a nutritional composition comprising an effective amount of a soluble mediator preparation from a late-exponential growth phase of a probiotic culture, such as lgg.. ... Coty Inc

06/14/18 / #20180161376

Compositions and methods for neuronal differentiation of cells

This invention relates to compositions and methods for enhanced differentiation of cells towards a neuronal phenotype. Neuronal cells produced using the compositions and methods may be used in the study of neurological diseases and disorders, for drug screening and for therapeutic purposes. ... Coty Inc

06/14/18 / #20180161375

Therapeutic method for repairing damaged pancreas

The invention is a therapeutic method for repairing damaged pancreas. The method comprises administrating epigallocatechin gallate (egcg) of green tea and a plurality of adipose-derived stem cells (adsc). ... Coty Inc

06/14/18 / #20180161371

Engineered natural killer cells and uses thereof

Disclosed herein are engineered natural killer cells that have been modified to express chimeric antigen receptors (cars). The cells optionally contain other modifications that improve tumor specific cytotoxicity and homing to tumor sites. ... Coty Inc

06/14/18 / #20180161368

Composition and methods for regulating inhibitory interactions in genetically engineered cells

Provided are engineered cells for adoptive therapy, including t cells. Also provided are methods and compositions for engineering and producing the cells, compositions containing the cells, and method for their administration to subjects. ... Coty Inc

06/14/18 / #20180161363

Bi-functional co-polymer use for ophthalmic and other topical and local applications

The invention contemplates a copolymer which is a graft or block copolymer useful to change wettability and surface characteristics of biological surfaces. Methods for use of these formulations and coatings to change wettability and sterically stabilize, and lubricate biological surfaces in a subject, for example, in the treatment of dry eye syndrome, and to prevent adherence of unwanted proteins, for example in the treatment of contact lens intolerance, are provided.. ... Coty Inc

06/14/18 / #20180161354

Nutritional formulations including human milk oligosaccharides and antioxidants and uses thereof

Disclosed are nutritional compositions including human milk oligosaccharides in combination with long chain polyunsaturated fatty acids and/or carotenoids that can be administered to preterm infants, term infants, toddlers, and children for reducing inflammation and the incidence of inflammatory diseases.. . ... Coty Inc

06/14/18 / #20180161353

Nutritional formulations including human milk oligosaccharides and antioxidants and uses thereof

Disclosed are nutritional compositions including human milk oligosaccharides in combination with long chain polyunsaturated fatty acids and/or carotenoids that can be administered to preterm infants, term infants, toddlers, and children for reducing inflammation and the incidence of inflammatory diseases.. . ... Coty Inc

06/14/18 / #20180161352

Nutritional formulations including human milk oligosaccharides and antioxidants and uses thereof

Disclosed are nutritional compositions including human milk oligosaccharides in combination with long chain polyunsaturated fatty acids and/or carotenoids that can be administered to preterm infants, term infants, toddlers, and children for reducing inflammation and the incidence of inflammatory diseases.. . ... Coty Inc

06/14/18 / #20180161351

Nutritional formulations including human milk oligosaccharides and antioxidants and uses thereof

Disclosed are nutritional compositions including human milk oligosaccharides in combination with long chain polyunsaturated fatty acids and/or carotenoids that can be administered to preterm infants, term infants, toddlers, and children for reducing inflammation and the incidence of inflammatory diseases.. . ... Coty Inc

06/14/18 / #20180161348

Osteoclast inhibitors such as zoledronic acid for low back pain treatment

Oral dosage forms of osteoclast inhibitors, such as zoledronic acid, in an acid or a salt form can be used to treat or alleviate pain or related conditions, such as modic changes type 1.. . ... Coty Inc

06/14/18 / #20180161346

Estriol therapy for treatment of multiple sclerosis

The present invention discloses administering steroid hormones to mammals to treat autoimmune related diseases, including post-partum auto immune diseases. Most preferably the invention uses estrogens, estranges, estriol or estrogen receptor active agents to prevent or ameliorate clinical symptoms of these th1-mediated (cell-mediated) autoimmune diseases known to either have an initial onset following the birth of a child or which are exacerbated in patients in the post-partum period.. ... Coty Inc

06/14/18 / #20180161339

Use of carbonic anhydrase inhibitors for treatment of neurological and psychiatric disorders

The invention is directed to the use of carbonic anhydrase inhibitors for treatment of neurological and psychiatric disorders.. . ... Coty Inc

06/14/18 / #20180161335

Methods to treat neurological diseases

Disclosed is a method of treating a subject who has a neurological disease. The neurological disease may be associated with altered c9orf72 protein activity. ... Coty Inc

06/14/18 / #20180161332

Treatment of mitochondrial diseases

The present invention provides a composition comprising one or more deoxyribonucleosides for use in the treatment of a mitochondrial dna depletion and/or multiple deletions syndrome provided that the syndrome is not caused by a defect in the deoxyribonucleoside triphosphate (dntp) metabolism. With the use of the invention there is a recovery in mitochondrial dna levels independently from the severity of the patient's disease, which confers a great therapeutic value to the invention.. ... Coty Inc

06/14/18 / #20180161331

Novel tetrahydropyridopyrimidine compound or salt thereof

A method for inhibiting androgen activity, including administering an effective amount of a tetrahydropyridopyrimidine compound of formula (i) or a pharmaceutically acceptable salt thereof to a subject in need thereof, and a method for treating tumor, including administering an effective amount of a tetrahydropyridopyrimidine compound of formula (i) or a pharmaceutically acceptable salt thereof to a subject in need thereof. . ... Coty Inc

06/14/18 / #20180161330

Thieno- and pyrrolopyrimidine analogues as anticancer agents and methods of use thereof

The present invention provides for the design and synthesis of halogenated thieno- and pyrrolopyrimidine compounds that exhibit cancer proliferation inhibitory activity and the use thereof for cancer treatment.. . ... Coty Inc

06/14/18 / #20180161329

Pyrido[3,4-d]pyrimidine derivative and pharmaceutically acceptable salt thereof

The purpose of the present invention is to provide a compound having an excellent cdk4/6 inhibiting activity. The present invention is a compound represented by general formula (i) or a pharmaceutically acceptable salt thereof.. ... Coty Inc

06/14/18 / #20180161328

Treatment of cancer and benign proliferative disorders

Disclosed herein are compositions comprising lopinavir alone or in combination with ritonavir for use as a medicament in the treatment of cancer or benign proliferative disorders (warts) or in the prevention of the development of cancer. Pharmaceutical compositions formulated for topical application comprising a therapeutically effective amount of lopinavir or a therapeutically effective amount lopinavir and ritonavir in a pharmaceutically acceptable vehicle are also provided. ... Coty Inc

06/14/18 / #20180161326

Pac-1 combination therapy

The invention provides compositions and methods for the induction of cancer cell death. The compositions and methods of using them include use of compositions in therapy for the treatment of cancer and for the selective induction of apoptosis in cancer cells. ... Coty Inc

06/14/18 / #20180161325

Pharmaceutical formulation containing tadalafil

Disclosed herein are pharmaceutical compositions comprising tadalafil, or a salt, or derivatives thereof and pharmaceutical excipients, processes for the preparation thereof, and pharmaceutical compositions containing them. The pharmaceutical compositions have improved physicochemical properties that provide faster onset of action for the treatment of erectile dysfunction.. ... Coty Inc

06/14/18 / #20180161324

Ship1 modulators and methods related thereto

N, r1, r4a, r4b, r5, r7 and r8 are defined herein, or pharmaceutically acceptable salts thereof, are described herein. The disclosed compounds have activity as ship1 modulators, and thus may be used to treat any of a variety of diseases, disorders or conditions that would benefit from ship1 modulation. ... Coty Inc

06/14/18 / #20180161322

Pharmaceutical composition

A preparation for oral administration comprising: a pregelatinized starch comprising n-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]-(2r,3r)-2,3-tetramethylene-butyl]-(1′r,2′s,3′r,4′s)-2,3-bicyclo[2,2,1]-heptanedicarboxyimide hydrochloride (lurasidone) represented by the formula (1) as an active ingredient; a water-soluble excipient; and a water-soluble polymeric binder, the preparation exhibiting an invariant level of elution behavior even when the content of its active ingredient is varied.. . ... Coty Inc

06/14/18 / #20180161321

Therapeutic uses of compounds having combined sert, 5-ht3 and 5-ht1a activity

New pharmaceutical uses of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine and pharmaceutically acceptable salts thereof are provided.. . ... Coty Inc

06/14/18 / #20180161318

Pharmaceutical composition for preventing and treating obesity or liver diseases, containg tlr7 agonist

The present invention is based on the fact that imiquimod, which is a substance that enhances toll-like receptor 7 (tlr7) related to the innate immunity of a living body, is effective in the prevention and treatment of obesity or liver disease, and the present invention relates to a pharmaceutical composition for the prevention and treatment of obesity or liver disease, wherein the tlr7 agonist used for the immune system disease inhibits fatty acid synthetase (fas), activates autophagosome or inhibits igf-1.. . ... Coty Inc

06/14/18 / #20180161317

Mesylic acid salt of acylthiourea compound, crystal of the same, and process for producing these

An object of the present invention is to provide a salt compound of 4-(2-fluoro-4-(3-(2-phenylacetyl)thioureido)phenoxy)-7-methoxy-n-methylquinoline-6-carboxamide, which is useful as an antitumor agent, and crystal of the salt. The salt and the crystal are excellent in terms of solubility, stability, and peroral absorbability and can be mass-produced. ... Coty Inc

06/14/18 / #20180161313

Inhibitors of mcl-1 as drugs to overcome resistance to braf inhibitors and mek inhibitors

The present invention includes compositions and methods for inhibiting mcl-1, including novel inhibitors of mcl-1, and compositions and methods for treating a subject with cancer that is refractory to one or more mapk pathway protein inhibitors.. . ... Coty Inc

06/14/18 / #20180161312

Substituted imidazoles as n-type calcium channel blockers

Wherein r1, r2, r3, and g are defined herein.. . ... Coty Inc

06/14/18 / #20180161311

Synthetic triterpenoids and methods of use in the treatment of disease

The present invention concerns methods for treating and preventing renal/kidney disease, insulin resistance/diabetes, fatty liver disease, and/or endothelial dysfunction/cardiovascular disease using synthetic triterpenoids, optionally in combination with a second treatment or prophylaxis.. . ... Coty Inc

06/14/18 / #20180161310

Compounds and methods for the treatment of neurological disorders

Compounds that inhibit synaptic hyperexcitability, pharmaceutical compositions of these compounds, and methods of using the compounds and pharmaceutical compositions thereof to treat diseases and/or disorders such as epilepsy, neuropathic pain, spinal cord injury spasticity, morphine-induced hyperalgesia, schizophrenia, and autism spectrum disorders are disclosed. In some embodiments, the compounds have the general structure of formula 1 or formula 2:. ... Coty Inc

06/14/18 / #20180161308

Self-emulsifying formulations of dim-related indoles

Disclosed herein are self-emulsifying compositions and formulations of diindolylmethane (“dim”) and certain derivatives of dim, their uses and methods of making. In particular, the disclosed compositions comprise a dim-related indole as an active agent and a carrier, wherein the carrier comprises a solvent, one or more surfactants with an hlb of greater than 7, and one or more co-surfactants with an hlb equal to or less than 7. ... Coty Inc

06/14/18 / #20180161303

Methods and compositions for inhibition of atr and fancd2 activation

This invention is announcing a composition of flavonoid skeleton in the formula i or formula ii compound, wherein each of the substituents is given the definition as set forth in the specification and claims. This composition have the capacity to treating or preventing a virus infection in a subject.. ... Coty Inc

06/14/18 / #20180161301

Concentrated liquid diet

The concentrated liquid diet disclosed is a concentrated liquid diet having a total amount of a medium-chain fatty acid having 8 carbon atoms and a medium-chain fatty acid having 10 carbon atoms included as constitutive fatty acids of a triglyceride being 2.5 to 8.0 g per 100 kcal of the energy of the concentrated liquid diet, the concentrated liquid diet having in the total mass of the medium-chain fatty acid having 8 carbon atoms and the medium-chain fatty acid having 10 carbon atoms the rate of the medium-chain fatty acid having 10 carbon atoms being no less than 60% by mass, and the rate of the medium-chain fatty acid having 8 carbon atoms being no greater than 40% by mass.. . ... Coty Inc

06/14/18 / #20180161299

Essential nutrients and related methods

The present disclosure relates to pharmaceutical compositions for mammalian consumption containing essential fatty acids, protein, vitamins and choline, or combinations thereof, so constituted to optimize absorption and/or transport and/or efficiency of the co-ingredients of the composition. The pharmaceutical compositions are useful as supplements to provide nutrients to nutritionally deficient patients. ... Coty Inc

06/14/18 / #20180161297

Benefits of supplementation with n-acetylcysteine and glycine to improve glutathione levels

The present invention concerns compositions and methods related to utilizing glycine and n-acetylcysteine for a variety of medical conditions related to reduced levels of glycine, n-acetylcysteine, and/or glutathione.. . ... Coty Inc

06/14/18 / #20180161295

Treatment of closed head injury and hemorrhagic stroke with hbed

The present invention provides methods for treating closed head injuries or hemorrhagic strokes using a compound of formula (i), or a pharmaceutically acceptable salt thereof. Compounds of formula (i) may act as iron chelators to prevent formation of highly reactive radicals leading to additional damage in the closed head injuries or hemorrhagic strokes.. ... Coty Inc

06/14/18 / #20180161292

Nutritional compositions containing butyrate and uses thereof

Provided are nutritional compositions containing dietary butyrate. Further disclosed are methods for promoting and/or accelerating myelination in a target subject via administering the nutritional composition containing dietary butyrate to the target subject.. ... Coty Inc

06/14/18 / #20180161289

Oral solution comprising atomoxetine hydrochloride and methods thereof

Disclosed herein is an oral pharmaceutical composition in the form of an aqueous solution of atomoxetine as an active ingredient. The aqueous solution of atomoxetine comprises a taste-masked liquid carrier comprising peppermint, orange flavor and a viscosity agent. ... Coty Inc

06/14/18 / #20180161278

Nozzle, apparatus, and method for producing microparticles

A nozzle, an apparatus, and a method are provided for mass production of dual-layer microparticles used as microcarriers. The nozzle includes a nozzle body having a first fluid passageway and a cover mounted to the nozzle body and having a second fluid passageway. ... Coty Inc

06/14/18 / #20180161277

Sustained delivery of therapeutic agents to an eye compartment

Compositions and methods for treating eye disorders by administering a drug delivery system into an eye compartment of the patient, wherein the drug delivery system contains a particle containing a core; a coating associated with the particle, wherein the coating is covalently or non-covalently associated with the particle and presents a hydrophilic region to the environment around the particle; and a therapeutic agent are disclosed. The eye compartment can exhibit reduced inflammation or iop after administration of the drug delivery systems to a patient than if a drug delivery system including an uncoated particle were administered to the patient.. ... Coty Inc

06/14/18 / #20180161276

Temperature-responsive composition, method for fabricating, and use thereof

The present disclosure provides a temperature-responsive composition including a nitric oxide donor and a carrier. The nitric oxide donor is a ph-dependent material, and the carrier is provided for carrying the nitric oxide donor with an effective amount. ... Coty Inc

06/14/18 / #20180161274

Liposome compositions encapsulating modified cyclodextrin complexes and uses thereof

The invention provides liposome compositions comprising liposomes encapsulating cyclodextrins that both bear ionizable functional groups, such as on their solvent-exposed surfaces, and encompass therapeutic agents, as well as uses thereof.. . ... Coty Inc

06/14/18 / #20180161272

Liposomal nanoconstructs and methods of making and using the same

Provided herein is a liposome comprising: a) a conjugate comprising a lysophospholipid and a photosensitizer; b) a first derivatized phospholipid comprising a first phospholipid and a strained cyclooctyne moiety; c) a second derivatized phospholipid comprising a second phospholipid and a polyethylene glycol polymer; and d) a cationic or anionic lipid. Also provided herein is a liposome comprising: a) a conjugate comprising a lysophospholipid and a photosensitizer; b) a first derivatized phospholipid comprising a first phospholipid and a targeting moiety; c) a second derivatized phospholipid comprising a second phospholipid and a polyethylene glycol polymer; and d) a cationic or anionic lipid. ... Coty Inc

06/14/18 / #20180161271

Controlled release antimicrobial compositions and methods for the treatment of otic disorders

Disclosed herein are compositions and methods for the treatment of otic diseases or conditions with antimicrobial agent compositions and formulations administered locally to an individual afflicted with an otic disease or condition, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).. . ... Coty Inc

06/14/18 / #20180161268

Cosmetic antioxidant formulation for topical use comprising an association of plant extracts, use thereof

The present invention provides stable antioxidant cosmetic formulations for topical use comprising green tea extract in combination with additional active compounds having the surprising ability to exert antioxidant effect on the skin, the use said formulations, as well as a method for reducing and/or preventing oxidative stress in keratinous tissues.. . ... Coty Inc

06/14/18 / #20180161267

Topical composition containing glycerin and yeast extract

The present invention provides a topical composition comprising (a) 0.5 to 25 weight percent of glycerin; (b) 0.1 to 5 weight percent of cetearyl olivate; (c) 0.1 to 5 weight percent of sorbitan olivate; and (d) 0.01.to 1 weight percent of extract of pichia anomala; wherein the composition is substantially free of fatty alcohols and is in the form of a gel cream.. . ... Coty Inc

06/14/18 / #20180161265

Cosmetic compositions

Disclosed are compositions and methods for their use that can be used individually or in combination. The compositions have the ability to treat a wide range of skin and skin conditions, and particularly men's skin.. ... Coty Inc

06/14/18 / #20180161262

Cosmetic method and dermatological topical agent for use therein, migration imparting agent, and method for screening components for use in cosmetic method for improving skin state

The present invention relates to a cosmetic method comprising applying a migration imparting agent for adipose-derived stem cells to the skin, thereby allowing adipose-derived stem cells to migrate to the dermal layer and improving a skin condition. The present invention also relates to an external skin preparation for use in the cosmetic method, the external skin preparation comprising a migration imparting agent allowing adipose-derived stem cells to migrate to the dermal layer by application to the skin. ... Coty Inc

06/14/18 / #20180161259

Stable personal care compositions containing a retinoid

Personal care compositions that include a stable o/w emulsion, a stable retinoid, an oil, a fatty alcohol, and an emulsifier and methods of using such compositions to regulate a condition of mammalian keratinous tissue. By combining the oil and retinoid at a particular ratio in the personal care composition, the stability of the retinoid can be improved.. ... Coty Inc

06/14/18 / #20180161255

Silicon oxide-coated zinc oxide, composition containing silicon oxide-coated zinc oxide, and cosmetic product

Provided is silicon oxide-coated zinc oxide, which can inhibit a decrease in viscosity resulting from a carbomer in a case where the silicon oxide-coated zinc oxide is used in water-based materials, a composition containing silicon oxide-coated zinc oxide, and a cosmetic product. The silicon oxide-coated zinc oxide of the present invention contains zinc oxide particles and a silicon oxide coating on a surface of the zinc oxide particles, in which an electric conductivity of a water suspension of the silicon oxide-coated zinc oxide is 120 μs/cm or less.. ... Coty Inc

06/14/18 / #20180161254

Hybrid-type multi-lamellar nanostructure of epidermal growth factor and liposome and method for manufacturing same

The present invention relates to a hybrid-type multi-lamellar nanostructure of an epidermal growth factor and a liposome and a method for manufacturing same. The new type of hybrid-type multi-lamellar nanostructure not only has a high epidermal growth factor encapsulating efficiency, but also can be manufactured through a simple process, such that the same can be easily delivered into a living body or a cell while maintaining a high physiological activity of the epidermal growth factor.. ... Coty Inc

06/14/18 / #20180161252

Microneedle delivery system and method

A microneedle device suitable for application to the skin and methods for using the same. The microneedles are made of one or more biocompatible polymers that optionally provide a cosmetic benefit when dissolved within the skin. ... Coty Inc

06/14/18 / #20180161251

Multilayer-color composite material for use in dental department, and preparation method therefor

A method for preparing a multilayer-color composite material for use in dental department comprises: preparing multiple types of monochromatic composite material precursor powder different in color, carrying out dry-pressing and preforming on the precursor powder, so as to obtain a preformed green body; and then carrying out pressurization and heating processing on the preformed green body, so as to obtain a multilayer-color composite material that gradually changes in color from neck portions to incisal ends of teeth, so that the multilayer-color composite material has a higher similarity to the material of natural teeth.. . ... Coty Inc

06/14/18 / #20180161250

Ion sustained-release dental hydraulic temporary sealing material composition

The present invention provides a dental hydraulic temporary sealing material composition on which a protection of tooth substance, such as tooth substance strengthening and control of secondary dental caries, can be expected by sustained-releasing various ions including a fluoride ion, while having a high initial setting ability. More specifically, the present invention provides a dental hydraulic temporary sealing material composition comprising 65.0% to 85.0% by mass of component (1): a hydraulic inorganic powder; 10.0% to 25.0% by mass of component (2): an organic solvent; 3.0% to 15.0% by mass of component (3): a resin; and 0.01% to 10.0% by mass of component (4): an ion sustained-release glass.. ... Coty Inc

06/14/18 / #20180161247

Tablet cassette rotor and tablet cassette

It is an object of the present invention to provide a tablet cassette rotor whose number of components is small and which can treat tablets having more various shapes and sizes and is adaptable to an automatic adjustment for a depth, a width and a partitioning position of a tablet guide path. As solving means for achieving this object, a rotor (4) which is rotatably contained in a cassette main body (3) for containing tablets and has a plurality of tablet guide paths (4b) for guiding the tablets to a tablet discharging hole. ... Coty Inc

06/14/18 / #20180161246

Compressed vaporizer tablet and method

There is disclosed a compressed vaporizer tablet and method. In an embodiment, the method comprises: obtaining one or more plant source materials containing one or more active medicinal ingredients; compressing the one or more plant source materials under pressure and heat into a tablet; and forming one or more through holes in the tablet, whereby the through holes provide increased tablet surface area during vaporization. ... Coty Inc

06/14/18 / #20180161244

Fluid transfer devices and methods of use

Fluid transfer systems are disclosed that can be configured to transfer precise amounts of fluid from a source container to a target container. The fluid transfer system can have multiple fluid transfer stations for transferring fluids into multiple target containers or for combining different types of fluids into a single target container to form a mixture. ... Coty Inc

06/14/18 / #20180161231

Methods, devices, and systems for inhibiting ocular refractive disorders from progressing

A method for retarding or reversing progression of myopia of a viewer contains the steps of using an immersive or non-immersive device to create a plurality of image planes in the eye of the viewer. While an image plane is located on the retina, at least one image plane is not on the retina, thereby generating myopic defocus. ... Coty Inc

06/14/18 / #20180161225

Patient support apparatus

A patient support apparatus includes a base frame, lift mechanism supporting an upper frame relative to the base frame, a load frame, and a plurality of deck sections, a patient support surface, and a number of barriers positioned about the patient supporting surface. The patient support apparatus includes a notification system for visually notifying a caregiver of a condition or status of a component of the patient support apparatus.. ... Coty Inc

06/14/18 / #20180161219

Decorative disposable undergarment

A decorative disposable undergarment which having features which make it a stronger, more fitted, and more aesthetic. The decorative disposable undergarment has a undergarment body formed from a disposable brief style undergarment that is constructed of a cotton-like fabric and includes a sewn in pad and a plurality of elastic, decorative retaining strips which each encircle the undergarment body and are attached to the exterior surface thereof. ... Coty Inc

06/14/18 / #20180161218

Absorbent product comprising inlet material

An absorbent product includes a liquid pervious topsheet, a liquid impervious backsheet and an absorbent core enclosed between the liquid pervious topsheet and liquid impervious backsheet. The absorbent product has in its longitudinal direction a crotch part and two end parts. ... Coty Inc

06/14/18 / #20180161214

Method for moving articles and controlling the position of same

A method for altering the appearance of molded articles is described herein. The method includes the steps of providing a plurality of articles; feeding a first article to a conveyor; transporting the first article to a treatment station; activating an activatable colorant of the first article by exposing the first article to at least one energy source, thereby causing a color change in the first article; manipulating the exposure of the first article to create a first discernable pattern in the first article; feeding a second article to the conveyor; transporting the second article to the treatment station; activating an activatable colorant of the second article by exposing the second article to the at least one energy source, thereby causing a color change in the second article; and manipulating the exposure of the second article to create a second discernable pattern in the second article.. ... Coty Inc

06/14/18 / #20180161209

Tympanic membrane pressure equalization tube

Systems, apparatus, and methods described herein relate to a tympanic membrane pressure equalization tube. The tympanic membrane pressure equalization tube can include a tubular body defining a lumen and having a proximal end and a distal end, where the tubular body is configured to be deployed in a tympanic membrane; and a fluid transport element disposed within the lumen and extending at least a length of the tubular body. ... Coty Inc

06/14/18 / #20180161208

Face protector

Provided is a face protector provided with a transparent film sheet to protect a viewing window of any one working mask selected from a safety face shield or a welding helmet. One or more transparent film sheets are inserted into a gap between the surface of the upper part of the viewing window and the bent inner surface of an upper support brim and thus combined with the surface of the viewing window, thereby preventing contaminants, paints, slag or metal particles, which may contaminate the viewing window during a working process, from being attached to the viewing window, securing a worker's clear view to increase worker safety, and to greatly extending the working mask.. ... Coty Inc

06/14/18 / #20180161202

Injector apparatus and method for drug delivery

Methods and apparatus provide a therapeutic fluid to devices implanted in the body, for example to containers of devices implanted in the eye of a patient. The methods and apparatus may comprise an injector to increase an amount of therapeutic agent injected into the device implanted in the eye, or a structure to receive the therapeutic fluid within the device implanted in the eye, or combinations thereof. ... Coty Inc

06/14/18 / #20180161200

Therapeutic wrap

The subject matter of the invention relates to therapy wraps for the application of compression and/or thermal therapy to a patient. The wraps are formed of at least two layers of material which are sealed together to form at least one cavity between them. ... Coty Inc

06/14/18 / #20180161197

Device, system and method of removing heat from subcutaneous lipid-rich cells

Devices, systems and methods for removing heat from subcutaneously disposed lipid-rich cells are disclosed. In selected embodiments, suction and/or heat removal sources are coupled to an applicator. ... Coty Inc

06/14/18 / #20180161192

Portable traction device with sling

A portable traction device can include a sling that is sized to cradle a user's head primarily at the back and lower part of the skull. The sling can be associated with flexible elastic tethers that are, in turn, associated with an anchor that is positioned a height above the floor when the portable traction device is in use. ... Coty Inc

06/14/18 / #20180161191

Vest-type maternity belt

A vest-type maternity belt according to the present invention includes: a vest maternity belt body (110) provided in the shape of a vest; size adjusting velcro members (120) configured such that female velcro members (121) and a male velcro member (122) are fixedly disposed on both sides of the front part of the maternity belt body (110) and a fastening function is provided; hook fastener members (130) configured such that hooks (131) and loops (132) are fixedly and oppositely disposed on both sides of the lower end portion of the front part of the maternity belt body (110) and the abdominal load of the pregnant woman can be borne; and spine correction elastic bands (140) formed as elastic members contained in the back part of the maternity belt body (110), and configured to support and correct the spine of the pregnant woman.. . ... Coty Inc

06/14/18 / #20180161188

Energy storage device for an exoskeleton

Disclosed herein is a leg exoskeleton configured to aid motion (e.g., walking) of a user in need thereof. In particular, the exoskeleton includes a belt configured to attach the exoskeleton to the waist of a user. ... Coty Inc

06/14/18 / #20180161187

Systems and methods for magnetically positioning a gastric device

A minimally invasive system and method for providing weight loss by inducing the feeling of satiety whereby an intragastric device is inserted into the gastric lumen via the esophagus and an external magnetic device is used as needed to magnetically attract the intragastric device towards the inner wall of the stomach and impart tactile stimulation sufficient to induce the feeling of satiety.. . ... Coty Inc

06/14/18 / #20180161185

Electrospun stents, flow diverters, and occlusion devices and methods of making the same

The instant disclosure is directed to medical devices having a lattice framework. The lattice framework may comprise a plurality of interconnected polymeric electrospun fiber members, or may comprise one or more wires formed into a plurality of interconnected members. ... Coty Inc

06/14/18 / #20180161183

System for connecting a prosthesis component to a prosthesis shaft

A shaft system for a leg prosthesis with the shaft system featuring a prosthesis shaft which has a wall made of fiber-reinforced plastic material and which features at its proximal end an entrance opening and at its distal end a fastening assembly for the connection of prosthesis components and the attachment of tensioning elements and functional parts of the prosthesis such as locks, draw-in and connecting elements. In order to enable on such a shaft system the feasibility and faster adaptability to the requirements of a user of this shaft system, it is proposed to provide the aforementioned passage opening with at least one reinforcement element. ... Coty Inc

06/14/18 / #20180161181

Locking device and motion assistance apparatus including the same

A locking device including a first frame including an insert hole and a first magnetic body, a second frame including an insert recess communicating with the insert hole, and a second magnetic body disposed to face the first magnetic body with a polarity opposite to a polarity of the first magnetic body, and an insert member including a slider inserted into the insert hole and configured to slide relative to the first frame, and a third magnetic body disposed on one side of the slider is provided.. . ... Coty Inc

06/14/18 / #20180161174

Method and apparatus for fusing a joint

Apparatus for stabilizing a first portion of bone relative to a second portion of bone, the apparatus comprising: a fusion barrel for disposition between the first portion of bone and the second portion of bone, the fusion barrel comprising: a generally-cylindrical body having a distal end, a proximal end, and a cavity formed in the generally-cylindrical body, the cavity comprising a distal end and a proximal end; at least one opening formed in the generally-cylindrical body in fluid communication with the cavity of the generally-cylindrical body; and a radially-extending flange extending distally and radially of the distal end of the generally-cylindrical body such that the radially-extending flange extends around at least a portion of the distal end of the generally-cylindrical body; wherein the radially-extending flange comprises a plurality of openings; and a cap configured to be releasably mounted to the proximal end of the generally-cylindrical body so as to substantially seal the proximal end of the cavity.. . ... Coty Inc

06/14/18 / #20180161172

Orthopaedic implant with porous structural member

An orthopaedic implant includes an implant body having a first surface, a second surface opposite the first surface, and a cavity formed therein that extends through the first surface and the second surface. The implant body has a third surface with at least one first opening formed therethrough to the cavity. ... Coty Inc

06/14/18 / #20180161168

Shoulder arthroplasty trial sensors

An arthroplasty trial assembly for a human shoulder can include a first implant securable to a first bone and a second implant securable to a second bone. The second implant can include a body, a stem, an articulation component, and a sensor. ... Coty Inc

06/14/18 / #20180161167

Arthroplasty systems and methods

Systems for joint arthroplasty include prostheses which are secured to bone with sliding anchors. Examples include unicondylar and bicondylar knee prostheses for hemi-arthroplasty and total arthroplasty. ... Coty Inc

06/14/18 / #20180161165

Releasable threaded connection for modular implants

An orthopaedic prosthesis assembly includes a first prosthetic component, a second prosthetic component, and a fastener. The first prosthetic component includes a threaded bore. ... Coty Inc

06/14/18 / #20180161163

Implants with frangible fastener port plugs and methods of manufacturing implants with frangible fastener port plugs

An orthopedic implant can comprise a structural body, a plug and a frangible connection. The structural body can comprise a first surface, a second surface opposing the first surface, and a through-bore extending from the first surface to the second surface. ... Coty Inc

06/14/18 / #20180161161

Methods, devices, and systems for percutaneously anchoring annuloplasty rings

Apparatus, systems, and methods are provided for percutaneous transcatheter delivery and fixation of annuloplasty rings to heart valves. An annuloplasty ring includes an outer tube, an inner body member, and an anchor deployment system. ... Coty Inc

06/14/18 / #20180161160

Percutaneous annuloplasty system with anterior-posterior adjustment

Apparatus, systems, and methods are provided for repairing heart valves through percutaneous transcatheter delivery and fixation of annuloplasty rings to heart valves. An annuloplasty ring includes an outer hollow body member including a plurality of regions. ... Coty Inc

06/14/18 / #20180161157

Commissure attachment features for improved delivery flexibility and tracking

A prosthetic heart valve includes a collapsible and expandable stent having a proximal end and a distal end. A plurality of commissure attachment features (“cafs”) is disposed on the stent, with each caf including a body and a plurality of eyelets. ... Coty Inc

06/14/18 / #20180161156

Transcatheter valve prosthesis

A heart valve system, the system including a radially self-expandable tubular body, a valve, and a tubular fabric. The tubular body having an inflow end and an outflow end. ... Coty Inc

06/14/18 / #20180161153

Modular intraocular lens designs, tools and methods

Modular iol systems including a base and a lens, wherein the lens includes fixed and actuatable tabs for connection to the base. The modular iol allows for the lens to be adjusted or exchanged while leaving the base in place, either intra-operatively or post-operatively. ... Coty Inc

06/14/18 / #20180161151

Bifurcated haptic aligner-actuators for accommodative intraocular lenses and exemplary aiols aligned and actuated thereby

Bifurcated haptic aligner actuators (bhaas) have an anterior and a posterior lens support ring to each of which is pivotively attached a plurality of center-pivoted struts, at least two of which comprise an opposing pair, and to each of the opposing pair of struts is pivotably attached a bifurcated haptic, one haptic branch being pivotably attached to the anterior part of a strut, the other branch of the same haptic being similarly attached to the posterior part of the same strut.. . ... Coty Inc

06/14/18 / #20180161143

Therapeutic agent coated angioplasty balloon with embolic filter and protective cover

Various implementations of a percutaneous transluminal angioplasty device include a catheter, a filter, and an expandable balloon. The filter is coupled adjacent a distal end of the catheter and is movable between an unexpanded and expanded configuration via a filter activation wire extending through a lumen of the catheter. ... Coty Inc

06/14/18 / #20180161142

Pulmonary nodule access devices and methods of using the same

A device for providing access to a nodule, lesion, or pathological area in a lung or other body organ or lumen. The device includes a sheath portion having a proximal end and a distal end and a plurality of stabilization wires. ... Coty Inc

06/14/18 / #20180161141

Surgical implant

A surgical implant (20) comprises a flexible basic structure (22) having a face and a plurality of resorbable film pieces (26) attached to the face of the basic structure (22). Each film piece (26) comprises a plurality of solid protrusions (28) emerging from the respective film piece (26) is a direction. ... Coty Inc

06/14/18 / #20180161139

Removal of occluded alkali metal cations from mse-framework type molecular sieves

A method for reducing the level of occluded alkali metal cations from an mse-framework type molecular sieve comprises either (a) contacting the molecular sieve with a solution containing ammonium ions at a temperature of at least about 50° c. To ammonium-exchange at least part of the occluded potassium ions or (b) contacting the molecular sieve with steam at a temperature of at least about 300° c. ... Coty Inc

06/14/18 / #20180161138

Vaginal band system

A device and system to improve sexual intercourse by adjusting the diameter of the vaginal channel. In one embodiment, a vaginal strap comprises an implantable elongated semi-flexible biocompatible strap having a first and a second side. ... Coty Inc

06/14/18 / #20180161137

Methods for use of sex sorted semen to improve genetic management in swine

The invention relates to methods of increasing genetic merit of swine by establishing a plurality of mating subtypes for a line of swine, and determining a percentage of progeny that are male for each of the mating subtypes, or a percentage of progeny that are female for each of the mating subtypes, that would result, relative to a control, in an increase in genetic merit in the line; the invention further relates to sorting a sperm cell sample from a male swine in one of the mating subtypes into one or more subpopulations of sperm cells, wherein a majority of sperm cells in a subpopulation of sperm cells bear x chromosomes or y chromosomes, and inseminating one or more female swine in the one of the mating subtypes with the subpopulation of sperm cells to achieve the percentage of progeny that are male, or the percentage of progeny that are female, determined to increase genetic merit relative to the control.. . ... Coty Inc

06/14/18 / #20180161136

Concurrent treatment of oral and systemic maladies using direct current electricity

A method and apparatus for the concurrent treatment of multiple oral diseases and defects while promoting general oral hygiene utilizing electricity are provided for non-human animals. Electrodes are used to deliver an electrical current to the gingival tissues of a mouth in order to achieve a number of therapeutic, prophylactic, and regenerative benefits. ... Coty Inc

06/14/18 / #20180161133

Dental prosthesis manufacturing aids

Dental prostheses may be manufactured based on electronic models of the prostheses. Manufacturing aids may be used to check manufacturing quality of the dental prosthesis and components thereof. ... Coty Inc

06/14/18 / #20180161132

Method and device for manufacturing and controlling the conformity of a dental prosthesis from parameters obtained with a shade selecting device

A device for tooth shade measurement comprising a housing, a handle and a measuring head, characterized in that said measuring head includes a hollow body extending along a longitudinal axis, said hollow body comprising a proximal end, a bent distal end relative to the longitudinal axis, said distal end being provided with a removable tip designed to come into contact with a tooth surface to be analyzed, at least one light source and image acquisition means, integral with the hollow body, said hollow body being adapted to transmit the light from said light source from the proximal end up to the distal end, and in that said device comprises an orientation assembly for mounting the proximal end of the hollow body in the housing so that the measuring head occupies different angular positions relative to the housing.. . ... Coty Inc

06/14/18 / #20180161128

Dental implant and abutment with nanotube arrays

Disclosed herein are biocompatible dental implant systems comprising: an implant body comprising a top collar; and an abutment comprising a first coupling region and a second coupling region; wherein the first coupling region is mechanically coupled to the top collar, and the second coupling region is mechanically coupled to a crown, and wherein at least a portion of a surface of the abutment includes one or more nanotube arrays, the one or more nanotube arrays comprising a plurality of nanotubes separated by a plurality of empty spaces.. . ... Coty Inc

06/14/18 / #20180161123

System and method for high density electrode management

Systems, devices and methods for advanced electrode management in neurological monitoring applications include receiving sockets configured to receive connectors having groups of electrodes. The physician is not required to manually map each electrode with its corresponding input channel. ... Coty Inc

06/14/18 / #20180161120

Method and apparatus for virtual endoscopy

A surgical instrument navigation system is provided that visually simulates a virtual volumetric scene of a body cavity of a patient from a point of view of a surgical instrument residing in the cavity of the patient. The surgical instrument navigation system includes: a surgical instrument; an imaging device which is operable to capture scan data representative of an internal region of interest within a given patient; a tracking subsystem that employs electro-magnetic sensing to capture in real-time position data indicative of the position of the surgical instrument; a data processor which is operable to render a volumetric perspective image of the internal region of interest from a point of view of the surgical instrument; and a display which is operable to display the volumetric perspective image of the patient.. ... Coty Inc

06/14/18 / #20180161117

Device for monitoring medicament delivery devices

The present disclosure relates to a device for handling medicament delivery devices and is to be used with a safety container, where the medicament delivery devices have information retaining elements having information that is unique to specific medicament delivery devices, and which medicament delivery devices are to be put in a safety container after use. The disclosed device has an information obtaining mechanism operably arranged to obtain information from the medicament delivery devices placed into the safety container.. ... Coty Inc

06/14/18 / #20180161115

Methods, systems, and devices relating to force control surgical systems

The various embodiments herein relate to robotic surgical systems and devices that use force and/or torque sensors to measure forces applied at various components of the system or device. Certain implementations include robotic surgical devices having one or more force/torque sensors that detect or measure one or more forces applied at or on one or more arms. ... Coty Inc

06/14/18 / #20180161106

System and technique for accessing extra articular lesions or abnormalities or intra osseous lesions or bone marrow lesions

A technique for accessing extra articular lesions or abnormalities or intra osseous lesions or abnormalities or bone marrow lesions or all has the step of positioning the localizing pinning member onto cartilage or subchondral bone to define a virtual pathway through the cartilage or subchondral bone towards or into or through the lesion or abnormality or a desired target to create the virtual pathway utilizing an intra articular localizing pinning member to determine a location of the lesion or abnormality wherein the utilization of the localizing pinning member includes the step to locate or stabilize or both and thereafter using the virtual pathway to create an entry access.. . ... Coty Inc

06/14/18 / #20180161102

Method and system for estimating a deflated lung shape for video assisted thoracic surgery in augmented and mixed reality

The present teaching relates to surgical procedure assistance. In one example, a first volume of air inside a lung is obtained based on a first image of the lung captured prior to a surgical procedure. ... Coty Inc

06/14/18 / #20180161101

Model-based surgical planning and implant placement

Systems and methods are provided for model-based surgical planning. A surgical planning system can include a prescreening tool configured to provide an initial classification of a set of patients according to a pelvic tilt, measured as a position of a pelvis of the patient relative to the position of a spine of the patient, in a plurality of body positions. ... Coty Inc

06/14/18 / #20180161100

Personalized computational modeling of atrial fibrosis to guide catheter ablation of atrial fibrillation

Methods, system, and media for identifying one or more ablation locations in an atrial tissue region in an atrial fibrillation (af) patient with atrial fibrosis are disclosed. Three-dimensional imaging data representing the atria of the patient may be received. ... Coty Inc

06/14/18 / #20180161098

Personalized refractive surgery recommendations for eye patients

Aspects extend to methods, systems, and computer program products for providing personalized surgery recommendations for eye patients. Surgery types, and surgery parameters can be recommended for a patient based on predicted post-operative ucva for the patient if the surgery types and surgery parameters were to be used. ... Coty Inc

06/14/18 / #20180161094

Fibroid ablation positioning device and methods

A method of treating a patient with a bioelectrical system is provided. The method may include inserting a probe into a first position in an anatomy of the patient, the system being provided with a plurality of electrodes; energizing a first electrode of the plurality of electrodes with a measurement level of power; determining a complex impedance in the patient's anatomy; determining whether the first position is a desired position of the probe for ablating a predetermined portion of tissue of the patient, based on the complex impedance determined; and energizing one of the plurality of electrodes with an ablation level of power, the ablation level of power being greater than the measurement level of power. ... Coty Inc

06/14/18 / #20180161093

Irrigated balloon catheter with support spines and variable shape

An irrigated balloon catheter, includes a balloon carrying contact electrodes, wherein a user can vary the balloon's configuration by manipulating an elongated expander that extends along the catheter and through the balloon's interior, with its distal end coupled to a distal end of the balloon. The expander may pass through an irrigation lumen to save on space within the catheter, and the expander itself may be hollow in providing a lumen for cables or lead wires. ... Coty Inc

06/14/18 / #20180161088

Arthroscopic devices and methods

An arthroscopy handpiece includes a handle body and a plurality of electrical components carried by the handle body. The electrical components may be connected to an external controller and power supply remote from the handle body. ... Coty Inc

06/14/18 / #20180161086

Immunotherapeutic methods using irreversible electroporation

Methods for treating tissue with irreversible electroporation and immunotherapy are described. The methods include placing a probe in tissue within a human body, wherein the probe has at least a first electrode, applying a plurality of electrical pulses through the first electrode and a second electrode, causing irreversible electroporation (ire) of the tissue within a target ablation zone, and administering one or more exogenous agents into the tissue within the target ablation zone or to the human, thereby stimulating or otherwise modulating an immune system response within the body.. ... Coty Inc

06/14/18 / #20180161085

Bipolar electrode for radio frequency ablation

A bipolar electrode for radio frequency ablation, the electrode including: a cylindrical body provided with first and second coupling grooves formed on an outer circumferential surface of the cylindrical body in a screw thread shape and spaced apart from each other at a predetermined interval; an active electrode body wound on the first coupling groove of the cylindrical body a plurality of times to be inserted thereinto, and connected to a first terminal of a radiofrequency generator; and a passive electrode body wound on the second coupling groove of the cylindrical body a plurality of times to be inserted thereinto, and connected to a second terminal of the radiofrequency generator. Thus, the electrode has effects of efficiently being moved to a vascular lesion such as varicose veins, and reducing a risk of thermal damage to surrounding tissue outside the lesion during treatment.. ... Coty Inc

06/14/18 / #20180161084

Treatment of headache

Headache treatment methods are described and include providing an energy delivery device; locating a secondary or higher-order branch of a postganglionic nerve that provides innervation for a patient's head, by identifying a target region of the patient's head that includes the nerve branch; positioning, within the target region, a portion of the energy delivery device; and applying, from the positioned portion of the energy delivery device to the target region, an amount of energy effective to result in a stimulation activity of the nerve branch; and, after observing the stimulated nerve branch activity, delivering, from the energy delivery device to the nerve branch, energy in an amount effective to reduce a headache severity in the patient.. . ... Coty Inc

06/14/18 / #20180161081

Stabilization systems

Devices, systems, and methods of bone stabilization. The bone stabilization system includes a mesh body. ... Coty Inc

06/14/18 / #20180161079

Intraosseous intramedullary fixation assembly and method of use

An intramedullary assembly for intraosseous bone fusion includes a lag screw member and a tapered screw member. The lag screw member includes a first elongated body, where the first elongated body includes a first threaded portion at a first end and a bulbous portion at a second end. ... Coty Inc

06/14/18 / #20180161078

Systems and methods for performing spine surgery

A digitizer pointer is provided as part of a system for correcting a curvature or deformity in a patient's spine based on the digitized locations of implanted screws and tracking the placement of the rod as it is placed in a minimally invasive fashion. The digitizer pointer is includes an offset adjustment feature, a swivel feature, and a translation feature.. ... Coty Inc

06/14/18 / #20180161076

Foaming agents and compositions containing fluorine substituted olefins, and methods of foaming

Various uses of fluoroalkenes, including tetrafluoropropenes, particularly (hfo-1336) in a variety of applications, including as blowing agents for integral skin foams are disclosed.. . ... Coty Inc

06/14/18 / #20180161074

Facet joint replacement device and methods of use

A facet joint replacement device includes an enclosing element including an enclosing body and an inferior attachment member. The enclosing body includes an inner cavity defined by an interior surface of the enclosing body, wherein a portion of the interior surface of the enclosing body forms a superior articulating surface. ... Coty Inc

06/14/18 / #20180161071

Polyaxial bone screw

A polyaxial bone screw for attaching a rod to a vertebra comprises a fastener having a threaded shank and a head. A yoke has a rod receiving channel for receiving the rod. ... Coty Inc

06/14/18 / #20180161070

Closure for open-headed medical implant

A closure for an open headed medical implant, such as a bone screw. The closure having a cylindrical body having an axis of rotation and also having a radially outer surface with a thread or other guide and advancement structure thereon. ... Coty Inc

06/14/18 / #20180161068

Mandibular fixation device

A mandibular fixation device is provided to overcome the low operability of the conventional mandibular fixation device. The mandibular fixation device includes a sleeve, a first screw rod, a second screw rod and two positioning members. ... Coty Inc

06/14/18 / #20180161064

Introducer with expandable capabilities

An example introducer is disclosed. An example introducer includes an inner liner including a lumen, a proximal region, and at least one folded portion extending longitudinally along the proximal region. ... Coty Inc

06/14/18 / #20180161063

Ultrasound observation apparatus, method of operating ultrasound observation apparatus, and computer readable recording medium

An ultrasound observation apparatus for generating an ultrasound image based on an ultrasound echo acquired by an ultrasound probe provided with an ultrasound transducer includes: a puncture needle detection unit configured to detect an image of a puncture needle displayed in the ultrasound image; a motion extraction unit configured to extract a linear motion at a point of the puncture needle based on a history of the image of the puncture needle in the ultrasound image; and a composite image generation unit configured to generate a composite image by generating loci of the linear motions extracted by the motion extraction unit and superimposing the loci on the ultrasound image, the composite image generation unit generating the composite image by using the loci of the linear motions having passed through a common section a plurality of times among the loci of the linear motions extracted by the motion extraction unit.. . ... Coty Inc

06/14/18 / #20180161051

Ocular ultrasound probe

Devices, systems and methods for ocular ultrasound are provided having therapeutic and/or diagnostic applications. In one aspect, an ocular probe is disclosed that is uniquely configured for use in the eye on the basis of shape and frequency. ... Coty Inc

06/14/18 / #20180161050

Method of delivering material or stimulus to a biological subject

A device for delivery of material or stimulus to targets within a body to produce a desired response, the targets being at least one of cells of interest, cell organelles of interest and cell nuclei of interest. The device includes a number of projections for penetrating a body surface, with the number of projections being selected to produce a desired response, and the number being at least 500. ... Coty Inc

06/14/18 / #20180161049

Orthopaedic surgical instrumentation for performing a patellofemoral arthroplasty procedure

A method and instrumentation for performing a patellofemoral arthroplasty orthopaedic procedure includes coupling an anterior cutting block to a femur of a patient such that the cutting block references local anatomy of the femur. The anterior cutting block is used to perform a number of bone cuts to establish a trochlear cavity in the femur. ... Coty Inc

06/14/18 / #20180161041

Total laparoscopic two-stage surgical method for resection of side of liver of patient via liver-surrounding band method

The present invention discloses a completely laparoscopic staged hepatectomy using round-the-liver ligation, which is carried out as follows: (1) a complete laparoscopic operation is performed with general anesthesia using round-the-liver ligation, the branches of the portal vein of the hemiliver to be removed are ligated, meanwhile a tourniquet is used to tighten the connecting part between the right and the left hemilivers to block the communicating blood flow between the hemiliver to be removed and the hemiliver to be reserved, a drainage tube is put into the peritoneal cavity at the hepatic hilus, then close the peritoneal cavity, and the operation is completed; (2) the patient gradually resumes eating after the first operation, and recuperate for 6-15 days to make the volume of the hemiliver to be reserved increase to the expected volume of the future liver remnant, in which the expected volume of the future liver remnant should be at least 30-40% of the standard liver volume; (3) after the volume of the hemiliver to be reserved has increased to the expected volume of the future liver remnant, a complete laparoscopic liver resection is carried out with general anesthesia to remove the diseased hemiliver, and then the patient is nursed to be completely recovered.. . ... Coty Inc

06/14/18 / #20180161033

Surgical systems and methods thereof

A system for introducing a surgical instrument through a tissue lumen having: a surgical instrument; a sheath for preventing contamination of the tissue lumen; a dilator for dilating bodily tissue having an elongated body for positioning the dilator and a tapered section for facilitating dilation of the tissue lumen; and a cone having conical body that tapers from the proximal end to the distal end and facilitates insertion of the cone and the surgical instrument through the tissue lumen, an axial bore that extends longitudinally through the cone and receives an anvil retainer, a collar that engages the distal end of the surgical device and prevents lateral movement of the cone, grooves that engage the surface of the tapered section and reduce the friction between the cone and the tissue lumen, a securing device for securing the cone to the surgical instrument, and a retrieval device for retrieving the cone from a bodily cavity.. . ... Coty Inc

06/14/18 / #20180161031

Suture packaging device

A suture tray having an upper component with a top surface and a bottom surface is disclosed. The tray also includes a plurality of flexible members integrally coupled to the upper component such that the flexible members have a clearance for assisting easy lift-press mechanism and a lower component having an outer peripheral wall and inner peripheral wall. ... Coty Inc








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