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Curis Inc patents


Recent patent applications related to Curis Inc. Curis Inc is listed as an Agent/Assignee. Note: Curis Inc may have other listings under different names/spellings. We're not affiliated with Curis Inc, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "C" | Curis Inc-related inventors


Mutant smoothened and methods of using the same

The emergence of mutations in tyrosine kinases following treatment of cancer patients with molecular-targeted therapy represents a major mechanism of acquired drug resistance. Here, mutations in the serpentine receptor, Smoothened (SMO) are described, which result in resistance to a Hedgehog (Hh) pathway inhibitor, such as in medulloblastoma. Amino acid substitutions... Curis Inc

Pyridyl inhibitors of hedgehog signalling

wherein A, X, Y R1, R2, R3, R4, m and n are as described herein.... Curis Inc

Phosphoinositide 3-kinase inhibitors with a zinc binding moiety

The instant application relates to deazapurines, thienopyrimidines and furopyrimidines with zinc-binding moiety based derivatives and their use in the treatment of phosphoinositide 3-kinase related diseases and disorders such as cancer. The instant application further relates to the treatment of histone deacetylase related disorders and diseases related to both histone deacetylase... Curis Inc

Hedgehog antagonists having zinc binding moieties

The present invention provides compounds which antagonize hedgehog signaling and inhibit HDAC activity. The compounds can be used in methods of treating proliferative diseases and disorders such as cancer.... Curis Inc

Phosphoinositide 3-kinase inhibitor with a zinc binding moiety

Pharmaceutical compositions comprising such compounds and the use of such compounds in the treatment of phosphoinositide 3-kinase related diseases and disorders such as cancer. The instant application further relates to the treatment of histone deacetylase related disorders and diseases related to both histone deacetylase and phosphoinositide 3-kinase.... Curis Inc

Fused amino pyridine as hsp90 inhibitors

The present invention relates to HSP90 inhibitors containing fused amino pyridine core that are useful as inhibitors of HSP90 and their use in the treatment of HSP90 related diseases and disorders such as cancer, an autoimmune disease, or a neurodegenerative disease.... Curis Inc

Mutant smoothened and methods of using the same

The emergence of mutations in tyrosine kinases following treatment of cancer patients with molecular-targeted therapy represents a major mechanism of acquired drug resistance. Here, mutations in the serpentine receptor, Smoothened (SMO) are described, which result in resistance to a Hedgehog (Hh) pathway inhibitor, such as in medulloblastoma. Amino acid substitutions... Curis Inc

Pyridyl inhibitors of hedgehog signalling

wherein A, X, Y R1, R2, R3, R4, m and n are as described herein.... Curis Inc

Fused amino pyridine as hsp90 inhibitors

The present invention relates to HSP90 inhibitors containing fused amino pyridine core that are useful as inhibitors of HSP90 and their use in the treatment of HSP90 related diseases and disorders such as cancer, an autoimmune disease, or a neurodegenerative disease.... Curis Inc








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This listing is an abstract for educational and research purposes is only meant as a recent sample of applications filed, not a comprehensive history. Freshpatents.com is not affiliated or associated with Curis Inc in any way and there may be associated servicemarks. This data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Curis Inc with additional patents listed. Browse our Agent directory for other possible listings. Page by FreshPatents.com

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