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Dh Technologies Development Pte Ltd patents


Recent patent applications related to Dh Technologies Development Pte Ltd. Dh Technologies Development Pte Ltd is listed as an Agent/Assignee. Note: Dh Technologies Development Pte Ltd may have other listings under different names/spellings. We're not affiliated with Dh Technologies Development Pte Ltd, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "D" | Dh Technologies Development Pte Ltd-related inventors


Lipid screening platform allowing a complete solution for lipidomics research

Known lipid molecules of a matrix are grouped into lipid classes and the lipid classes are further grouped into a pass-through group and a mobility separation group based on isobaric interferences. A separation system separates known lipid molecules from a matrix sample and an ion source ionizes the matrix sample.... Dh Technologies Development Pte Ltd

Time-of-flight analysis of a continuous beam of ions by a detector array

Systems and methods are provided for time-of-flight analysis of a continuous beam of ions by a detector array. A sample is ionized using an ion source to produce a continuous beam of ions. An electric field is applied to the continuous beam of ions using an accelerator to produce an... Dh Technologies Development Pte Ltd

Rapid detection of microbial resistance to lactam antibiotics by lc-ms/ms

A rapid screening process is provided for identification of bacterial resistance to antibiotics by utilizing LC-MS/MS to quantitate concentrations of parent drugs and also detect hydrolysis products which result from beta-lactamase activity. The susceptibility testing is accomplished in time periods as short as 90 minutes, which includes incubation of bacteria... Dh Technologies Development Pte Ltd

Rapid scanning of wide quadrupole rf windows while toggling fragmentation energy

A sample is ionized using an ion source and the ion beam is received using a tandem mass spectrometer. An m/z range is divided into two or more precursor ion isolation windows. Two or more values for a fragmentation parameter are selected. A first value of the two or more... Dh Technologies Development Pte Ltd

Device for improved detection of ions in mass spectrometry

An electron multiplier is positioned relative to at least one dynode to direct a beam of secondary particles from the at least one dynode to a collector area of the electron multiplier and not to a channel area of the electron multiplier for a range of electron multiplier voltages applied... Dh Technologies Development Pte Ltd

Differential mobility spectrometry method

Methods and systems are provided herein for varying the CoV about a nominal CoV-apex while monitoring the ion of interest corresponding to the nominal CoV-apex as it is transmitted by a DMS. In various aspects, the CoV can be swept or stepped across a series of values during the injection... Dh Technologies Development Pte Ltd

Electron induced dissociation devices and methods

A method and apparatus for conducting reactions between precursor ions and reagent ions, for example, a reaction between a precursor cation and an electron, such as ECD, are disclosed. The apparatus comprises first, second, and third pathways, each of which extends at least partially along a central axis, and wherein... Dh Technologies Development Pte Ltd

Methods for protein and peptide reduction

Methods and systems are provided herein for on-line preparation of a sample for mass spectrometry. In accordance with various aspects of applicant's teachings, the methods and systems can provide for the reduction of a polypeptide, for example, on a liquid chromatography column and can reduce or eliminate the need to... Dh Technologies Development Pte Ltd

Fourier transform ion cyclotron resonance mass spectrometry

Methods and systems for analyzing ions in a magnetic ion trap are provided herein. In accordance with various aspects of the present teachings, the methods and systems described herein enable Fourier transform ion cyclotron resonance mass spectrometry across relatively narrow gap magnetic fields substantially perpendicular to the axis along which... Dh Technologies Development Pte Ltd

Methods and systems for cross-talk elimination in continuous beam mobility-based spectrometers

A sample analysis system having a continuous beam ion mobility filter incorporates an ion removal mechanism for removing residual ions from the ion mobility filter to reduce cross-talk. A sample to be analyzed by the sample analysis system can be entered into the continuous beam ion mobility filter, which filters... Dh Technologies Development Pte Ltd

Methods and systems for selecting ions for ion fragmentation

The present teachings are directed to methods and systems for the selection of ions for subsequent ion fragmentation in the analysis of a sample. Rather than select the most intense subset of precursor ions for further analysis in an attempt to maximize the number of high quality, identifiable MS/MS spectra,... Dh Technologies Development Pte Ltd

Sampling interface for mass spectrometry systems and methods

Methods and systems for delivering a liquid sample to an ion source for the generation of ions and subsequent analysis by mass spectrometry are provided herein. In accordance with various aspects of the present teachings, MS-based systems and methods are provided in which a desorption solvent utilized in a sampling... Dh Technologies Development Pte Ltd

Mass filtering of ions using a rotating field

Systems and methods for filtering a continuous beam of ions are provided. An acceleration electric field is applied to a continuous beam of ions using an accelerator to produce an accelerated beam of ions. A field is applied to the accelerated beam to separate ions in time and space using... Dh Technologies Development Pte Ltd

Rf ion guide

A mass spectrometer is provided having an ion source for generating ions from a sample in a high pressure region, a first vacuum chamber having an inlet aperture, and an exit aperture. The at least one ion guide can be between the inlet and exit apertures and can include an... Dh Technologies Development Pte Ltd

Device for ion sorting by m/z

An RF voltage is applied across each electrode of a first array of evenly spaced, parallel, and coplanar electrodes and its corresponding electrode of a second array of evenly spaced, parallel, and coplanar electrodes. The RF voltage varies in amplitude according to an RF voltage amplitude gradient. The RF voltage... Dh Technologies Development Pte Ltd

Methods for detection in differential mobility spectrometer using a peptide metal complex

Methods and systems for separating and/or quantifying peptides using differential mobility spectrometry (DMS) are provided herein. In accordance with various aspects of the applicant's teachings, the methods and systems can provide for the separation of one or more peptides, for example, peptides that may be difficult to separate with conventional... Dh Technologies Development Pte Ltd

Dynamic orthogonal analysis method

Systems and methods are provided for providing a DMS precursor ion survey scan. An ion source configured to receive a sample is instructed to ionize the sample using a processor. A DMS device configured to receive ions from the ion source is instructed to separate precursor ions received from the... Dh Technologies Development Pte Ltd

Ion sorter

A static magnetic field is applied in the same direction using a first magnet and a second magnet. The magnetic field is applied to a gap of uniform thickness between the first and second magnets. Voltages are applied to three or more electrodes located in the gap using a switchable... Dh Technologies Development Pte Ltd

Grouping amplitudes of tof extractions to detect convolution due to resolution saturation

Sample molecules are ionized producing a beam of ions using an ion source. A plurality of ion extractions are performed on the beam of ions using a TOF mass spectrometer. Electrical detections from each extraction are measured using an ADC, producing a mass sub-spectrum for each extraction. An ion m/z... Dh Technologies Development Pte Ltd

Ion mobility method and apparatus

A method and system for performing an ion mobility based analysis that ionizes the components of a sample into ions; provides a field asymmetric waveform ion mobility or differential mobility spectrometry ion mobility based filter that comprises at least two electrodes, the at least two electrodes being spaced apart such... Dh Technologies Development Pte Ltd

Band pass extraction from an ion trapping device and tof mass spectrometer sensitivity enhancement

A multipole rod set of an ion guide is adapted to receive a radial RF trapping voltage and a radial dipole direct current DC voltage. A lens electrode of the ion guide is positioned at one end of the multipole rod set to extract ions from the multipole rod set... Dh Technologies Development Pte Ltd

Methods for distinguishing dioleinates of aged and non-aged olive oil

Systems and methods are provided for selectively filtering 1,2-diolein and 1,3-dioleine ions from an olive oil sample. An ion source is instructed to ionize a mixture of an olive oil sample and a pre-ionization modifier. The pre-ionization modifier includes silver (Ag). A differential mobility spectrometry (DMS) device is instructed to... Dh Technologies Development Pte Ltd

Devices and methods for processing fluid samples

Provided is the processing of sample fluids containing one or more analytes of interest and to methods and devices for separating and/or purifying components of a sample fluid using electric and hydrodynamic forces. Though the fluid processing systems and methods are generally described herein as applied to microfluidics, it will... Dh Technologies Development Pte Ltd

Devices and methods for processing fluid samples

Provided is the processing of sample fluids containing one or more analytes of interest and to methods and devices for separating and/or purifying components of a sample fluid using electric and hydrodynamic forces. Though the fluid processing systems and methods are generally described herein as applied to microfluidics, it will... Dh Technologies Development Pte Ltd

Crosstalk compensation for ion mobility spectrometry power supply

Apparatus, systems, and methods for reducing or eliminating crosstalk in ion mobility spectrometers are provided. In some aspects, the apparatus, systems, and methods can reduce or eliminate crosstalk without significantly increasing the overall capacitive load of the ion mobility system. In accordance with various aspects of the applicant's teachings, cross... Dh Technologies Development Pte Ltd

Crosstalk compensation for ion mobility spectrometry power supply

Apparatus, systems, and methods for reducing or eliminating crosstalk in ion mobility spectrometers are provided. In some aspects, the apparatus, systems, and methods can reduce or eliminate crosstalk without significantly increasing the overall capacitive load of the ion mobility system. In accordance with various aspects of the applicant's teachings, cross... Dh Technologies Development Pte Ltd

Contamination filter for mass spectrometer

Methods and systems for performing mass spectrometry are provided herein. In accordance with various aspects of the applicants' teachings, the methods and systems can utilize an ion mobility spectrometer operating at atmospheric or low-vacuum pressure to remove the major contributors to the contamination and degradation of critical downstream components of... Dh Technologies Development Pte Ltd

Methods for analysis of lipids using mass spectrometry

A method and apparatus for analyzing samples using mass spectrometry are disclosed. The apparatus includes a reaction device configured to dissociate sample ions into fragments by reacting the sample ions with a charged species (e.g., electrons) such as through ECD, EID, or EIEIO. The kinetic energy of the charged species... Dh Technologies Development Pte Ltd

Specific analysis of ketone and aldehyde analytes using reagent compounds, labeling strategies, and mass spectrometry workflow

Labeling reagents, sets of labeling reagents, and labeling techniques are provided for the relative quantitation, absolute quantitation, or both, of ketone or aldehyde compounds including, but not limited to, analytes comprising steroids or ketosteroids and includes testosterone. The analytes can be medical or pharmaceutical compounds in biological samples. Methods for... Dh Technologies Development Pte Ltd

Method for converting mass spectral libraries into accurate mass spectral libraries

At least one product ion mass spectrum produced by a tandem mass spectrometer is received. A chemical structure of a compound that corresponds to the at least one product ion mass spectrum is received. One or more elemental compositions are assigned to at least one peak in the at least... Dh Technologies Development Pte Ltd

Systems and methods for rapidly screening samples by mass spectrometry

Systems and methods are used to rapidly screening samples. A fast sample introduction device that is non-chromatographic is instructed to supply each sample of a plurality samples to a tandem mass spectrometer using a processor. The fast sample introduction device can include a flow injection analysis device, an ion mobility... Dh Technologies Development Pte Ltd

Fluid transfer from digital microfluidic device

Methods and systems for processing fluids utilizing a digital microfluidic device and transferring droplets from the digital microfluidic device to a downstream analyzer are described herein. Methods and systems in accordance with the present teachings can allow for the withdrawal of fluid from a digital microfluidic device, and can in... Dh Technologies Development Pte Ltd

Magnetic elements for processing fluids

Methods and apparatus for processing fluids on a macro- or micro-scale are described. In various aspects, a fluid may have a plurality of elongated (i.e., substantially rod-shaped) magnetic elements disposed therein within a fluid container. An illustrative fluid container is an actuator electrode or a processing vial of a microfluidic... Dh Technologies Development Pte Ltd

Microbial identification and quantitation using ms cleavable tags

Systems and methods are provided for microbial identification using cleavable tags. Control information is sent to a mass spectrometer to select a peptide labeled with a first tag of a known microbe, fragment the labeled peptide of the known microbe, and monitor for an intensity of the first tag in... Dh Technologies Development Pte Ltd

Multi-trace quantitation

Systems and methods are provided for calculating the area of a peak profile using information from one or more correlated peak profiles. One or more compounds are separated from a mixture over time using a separation device. Traces of the one or more compounds are monitored during the separation using... Dh Technologies Development Pte Ltd

02/02/17 / #20170032949

Ion source for mass spectrometry

Systems and methods for delivering a sample to a mass spectrometer are provided. In one aspect, the systems and methods can provide efficient cooling of an ion source probe to prevent overheating and the resulting degradation in ion sampling. In some aspects, such cooling can result in improved consistency and/or... Dh Technologies Development Pte Ltd

02/02/17 / #20170032953

Mass spectrometer

Methods and apparatus for operating a mass spectrometer are described. In various aspects, ions of a mass range of interest may be mass-selectively ejected from an accumulation ion trap into a multi-ion trap structure. Each ion trap of the multi-ion trap structure may be configured to confine ions within a... Dh Technologies Development Pte Ltd

02/02/17 / #20170032948

Data independent acquisition of product ion spectra and reference spectra library matching

Systems and methods are disclosed for analyzing a sample using overlapping precursor isolation windows. A mass analyzer of a tandem mass spectrometer is instructed to select and fragment at least two overlapping precursor isolation windows across a precursor ion mass range of a sample using a processor. The tandem mass... Dh Technologies Development Pte Ltd

02/02/17 / #20170032949

Ion source for mass spectrometry

Systems and methods for delivering a sample to a mass spectrometer are provided. In one aspect, the systems and methods can provide efficient cooling of an ion source probe to prevent overheating and the resulting degradation in ion sampling. In some aspects, such cooling can result in improved consistency and/or... Dh Technologies Development Pte Ltd








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