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Duke University patents


Recent patent applications related to Duke University. Duke University is listed as an Agent/Assignee. Note: Duke University may have other listings under different names/spellings. We're not affiliated with Duke University, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "D" | Duke University-related inventors


Stereoscopic display displaying surgical data and information in a surgical microscope

Stereoscopic display systems and methods for displaying surgical data and information in a surgical microscope are disclosed herein. According to an aspect, a system includes first and second eyepieces. The system includes a display having first and second display portions, configured to display first images in the first display portion,... Duke University

Systems and methods for endoscopic angle-resolved low coherence interferometry

A method of assessing tissue health comprises the steps of obtaining depth-resolved spectra of a selected area of in vivo tissue, and assessing the health of the selected area based on the depth-resolved structural information of the scatterers. Obtaining depth-resolved spectra of the selected area comprises directing a sample beam... Duke University

Compositions for the sustained release of anti-glaucoma agents to control intraocular pressure

Controlled release dosage formulations for the delivery of active agents, especially for treatment of eye diseases or disorders, such as glaucoma, have been developed. These provide release of the active agent, such as ECA or a derivative thereof, for an effective period of time.... Duke University

Specialized robot motion planning hardware and methods of making and using same

Specialized robot motion planning hardware and methods of making and using same are provided. A robot-specific hardware can be designed using a tool that receives a robot description comprising a collision geometry of a robot, degrees of freedom for each joint of the robot, and joint limits of the robot;... Duke University

Compositions and methods for the prevention and treatment of mast cell-induced vascular leakage

Disclosed herein are methods of diagnosing and treating infectious disease characterized by a pathology that involves hemorrhaging or pathological vascular leakage.... Duke University

Compounds and methods for targeting hsp90

Described herein are compounds that may selectively bind to Hsp90, methods of using the compounds, and kits including the compounds. The compounds may include detection moieties such as fluorophores that may allow for selective detection of Hsp90 in a sample.... Duke University

Enzyme-catalyzed synthesis of site-specific and stoichiometric biomolecule-polymer conjugates

Methods for producing polypeptide-polymer conjugates include attachment of an initiator agent to a polypeptide specifically at the C-terminus of the polypeptide using a sortase enzyme and in situ polymerization of a polymer from the C-terminus. The polypeptide-polymer conjugates may have desirable pharmacological properties and may be used therapeutically.... Duke University

Factor v/va-targeting aptamer compositons and methods of using the same

Provided herein are Factor V/Factor Va-targeting aptamer compositions and antidote compositions targeting such aptamer compositions. Methods for preventing blood clots using such compositions are also provided.... Duke University

Apparatus and providing a selectively absorbing structure

An apparatus is described that selectively absorbs electromagnetic radiation. The apparatus includes a conducting surface, a dielectric layer formed on the conducting surface, and a plurality of conducting particles distributed on the dielectric layer. The dielectric layer can be formed from a material and a thickness selected to yield a... Duke University

Compositions and methods for treating hair loss using non-naturally occurring prostaglandins

A method for treating hair loss in mammals uses compositions containing prostaglandin F analogs. The compositions can be applied topically to the skin. The compositions can arrest hair loss, reverse hair loss, and promote hair growth.... Duke University

Non-regular electrical stimulation patterns for treating neurological disorders

Systems and methods for stimulation of neurological tissue generate stimulation trains with temporal patterns of stimulation, in which the interval between electrical pulses (the inter-pulse intervals) changes or varies over time. Compared to conventional continuous, high rate pulse trains having regular (i.e., constant) inter-pulse intervals, the non-regular (i.e., not constant)... Duke University

Ethynylbenzene derivatives

Disclosed are compounds of formulae (I), (II), and (II)I: and pharmaceutically acceptable salts thereof, wherein the variables, R, R1, R2, R3, R101, L, D, Q, Y, X, and Z are defined herein. These compounds are useful for treating Gram-negative bacteria infections.... Duke University

Multi-layer integrated circuits having isolation cells for layer testing and related methods

Multi-layer integrated circuits having isolation cells for layer testing and related methods are disclosed. According to an aspect, an integrated circuit includes first and second layers that each have one or more electronic components. One or more electronic components of each layer can be electrically connected by a first via... Duke University

Stretchable electrically conductive layer formation by aerosol jet printing on flexible substrate

Methods of forming an electrically conductive layer on a flexible substrate, such as a stretchable electrode, by aerosol jet printing on the flexible substrate while the substrate is strained. In general, a stretchable substrate is initially deformed so that a first surface thereof is under tension. While the substrate is... Duke University

Self-gated interleaved radial mri for abdominothoracic imaging

The present disclosure provides, in part, methods for high spatiotemporal resolution self-sorted 4D MRI. These methods can be used to improve resolution of abdominothoracic MRI during breathing by facilitating the sorting of information corresponding to individual MRI pulse sequences according to phase within the respiratory cycle. An image of the... Duke University

Treatment method and product for uterine fibroids using purified collagenase

The invention relates to compositions and methods for treating uterine fibroids, wherein a uterine fibroid treatment agent comprising collagenase in an amount effective to cause shrinkage of uterine fibroids is injected or inserted into the uterine fibroid.... Duke University

Rationally-designed meganucleases with altered sequence specificity and dna-binding affinity

Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment... Duke University

Composition and treatment of neuropsychiatric disorders

The present invention relates to a composition and method for combinative therapy, capable of temporarily regulating inherent dysfunctional neural processes and reducing symptoms and/or signs of neuropsychiatric disorders including, but not limited to, psychostimulant use disorder (PUD) and other substance-related additive disorders, post-traumatic stress disorder (PTSD) and other trauma- and... Duke University

Use of caspase-2 inhibitors to treat and prevent the metabolic syndrome

Methods and compositions for treatment of obesity, insulin resistance, hyperinsulinemia, type 2 diabetes mellitus, dyslipidemia, and nonalcoholic fatty liver disease are discloses. The methods and compositions relate to inhibition of caspase-2.... Duke University

Swarm immunization with 54 envelopes from ch505

In certain aspects the invention provides HIV-1 immunogens, including envelopes (CH505) and selections therefrom, and methods for swami immunizations using combinations of HIV-1 envelopes.... Duke University

Contrast agents based on long-lived nuclear singlet states and related methods

Methods are described for preparing magnetic resonance imaging (MRI) and/or magnetic resonance spectroscopy contrast agents where the contrast agents are prepared from precursor molecules having at least four non-zero-spin nuclei that form two pairs of chemically equivalent or effectively equivalent nuclei, e.g., diphenylacetylene or diethyl oxalate. The precursor molecule is... Duke University

Methods for in vivo identification of endogenous mrna targets of micrornas

A method of generating a gene expression profile of noncoding regulatory RNA (ncRNA; e.g. a microRNA) in a cell in vivo, is carried out by: (a) partitioning from a cell at least one mRNA-protein (RNP) complex, the RNP complex comprising: (i) an RNA binding protein (RNABP) or RNA associated protein,... Duke University

Methods of treating hemoglobinopathies

Methods of alleviating the symptoms of hemoglobinopathies, including, but not limited to, sickle cell disease, β-thalassemia, and hemoglobin H disease are provided. In some embodiments, the methods comprise administering an inhibitor selected from an ERK inhibitor, a MEK inhibitor, and, a Raf inhibitor. Methods of inhibiting adhesion of sickle red... Duke University

Phosphors and scintillators for light stimulation within a medium

A system and method for light stimulation within a medium. The system has a reduced-voltage x-ray source configured to generate x-rays from a peak applied cathode voltage at or below 105 kVp, and a plurality of energy-emitting particles in the medium which, upon radiation from the x-ray source, radiate at... Duke University

Nano-plasmonic molecular probes for plasmonics coupling interference

Plasmonics-active nanoprobes are provided for detection of target biomolecules including nucleic acids, proteins, and small molecules. The nucleic acids that can be detected include RNA, DNA, mRNA, microRNA, and small nucleotide polymorphisms (SNPs). The nanoproprobes can be used in vito in sensitive detection methods for diagnosis of diseases and disorders... Duke University

Biosensor

Biosensors are made by attaching covalently or non-covalently at least one reporter group to one or more specific positions of a bacterial periplasmic binding protein (bPBP). Upon binding of ligand to the biosensor, there is a change in the signal transduced by the reporter group.... Duke University

Magnetic resonance imaging of neuro-electro-magnetic oscillations

In vivo methods of non-invasively imaging neuro-electro-magnetic oscillations (NEMO) are carried out by electronically transmitting a pulse sequence to a subject. The pulse sequence has a first excitation pulse, typically applied along an x-axis, followed by a spin-lock pulse applied along a different axis, typically a y-axis, and having a... Duke University

Whole eye optical coherence tomography(oct) imaging systems and related methods

Whole eye optical coherence tomography (OCT) imaging systems and related methods are disclosed. According to an aspect, an OCT imaging system includes a source having an associated source arm path. Further, the OCT imaging system includes a reference arm coupled to the source arm. Further, the OCT imaging system includes... Duke University

Compositions comprising ch848 envelopes and uses thereof

In certain aspects the invention provides immonogenic compositions comprising CH848 HIV-1 envelopes and their use in methods to induce immune responses in subjects, e.g., human subjects.... Duke University

Waveform shapes for treating neurological disorders optimized for energy efficiency

Systems and methods for stimulation of neurological tissue apply a stimulation waveform that is derived by a developed genetic algorithm (GA), which may be coupled to a computational model of extracellular stimulation of a mammalian myelinated axon. The waveform is optimized for energy efficiency.... Duke University

Systems, compositions and devices for in vivo magnetic resonance imaging of lungs using perfluorinated gas mixtures

Systems and methods for generating MRI images of the lungs and/or airways of a subject using a medical grade gas mixture comprises between about 20-79% inert perfluorinated gas and oxygen gas. The images are generated using acquired 19F magnetic resonance image (MRI) signal data associated with the perfluorinated gas and... Duke University

Compositions, the encapsulation and delivery of a substance

A composition and method is provided for synthesizing silicone particles with narrow size distributions and tunable degrees of crosslinking for encapsulation of an active ingredient or multiple active ingredients in the matrix of the particles for controlled release. The method comprises agitating at least one type of silane monomer having... Duke University

Compositions and methods for the prevention and/or reduction of scarring

The present disclosure provides methods of preventing and/or reducing scar contraction by utilizing an electrospun biocompatible scaffold.... Duke University

Systems and methods for the verification of source placement for brachytherapy radiation procedures using real time radiation detectors

The present disclosure provides systems and methods for verifying radiation source delivery in brachytherapy by allowing for the radiation source location and dwell time to be determined via real-time measurement. In an embodiment, a radiation detector may be disposed proximate to a radiotherapy target. The radiation detector is configured to... Duke University

Systems and methods for genetic analysis of intractable microbes

Embodiments of the present disclosure relate generally to the genetic analysis of intractable microbes. More particularly, the present disclosure provides materials and methods that incorporate chemical mutagenesis, phenotypic selection, suppression analysis, and genomic sequencing-based mutational mapping, to identify novel genetic regulators in previously intractable organisms, such as microbes that constitute... Duke University

10/26/17 / #20170307349

Non-invasive thickness measurement using capacitance measurement

Methods of measuring thickness of a material using cross-capacitance. The method generally includes applying a time-varying signal to a first pad and monitoring a response of a capacitor formed by the first pad, a spaced apart second pad, and the material. The pads may be permanently affixed to the material,... Duke University

10/19/17 / #20170298331

Genetic correction of mutated genes

Disclosed herein are transcription activator-like effector nuclease (TALEN)-related compositions and methods of using said TALENs for correcting mutant genes.... Duke University

10/19/17 / #20170299655

Signal tracing using on-chip memory for in-system post-fabrication debug

A post-fabrication debug and on-line error checking framework for 2D- and 3D-ICs with integrated memories is described. A design-for-debug (DfD) architecture can include, for an IC with on-chip memory, a debug module connected to a functional bus of the IC. The debug module receives trace data for an interval, generates... Duke University

10/19/17 / #20170299784

Nanopatch antennas and related methods for tailoring the properties of optical materials and metasurfaces

Nanopatch antennas and related methods for enhancing and tailoring are disclosed. According to an aspect, an apparatus includes a conductive material defining a substantially planar surface. The apparatus also includes a conductive nanostructure defining a substantially planar surface. The conductive material and the conductive nanostructure are positioned such that the... Duke University

10/12/17 / #20170290650

Implantable mesh and use

An implantable mesh for use in reconstructing tissue includes a mesh body and one or more extensions extending from the mesh body. Each mesh extension has a first end and a second end, wherein the first end of the mesh extension is integrated into or part of the mesh body.... Duke University

10/12/17 / #20170294248

Noble metal-coated nanostructures and related methods

Noble metal-coated nanostructures and related methods are disclosed. According to an aspect, a nanostructure may include a structure comprising a base metal. As an example, the structure may be a nanowire. In a more specific example, the structure may be a copper nanowire or a nanowire made of a base... Duke University

10/05/17 / #20170281749

Compositions comprising ch505 envelopes, and trimers

In certain aspects the invention provides a selection of HIV-1 envelopes suitable for use as immunogens, and methods of using these immunogens to induce neutralizing antibodies. In certain embodiments, the immunogens are designed to trimerize. In other embodiments, the immunogens comprise an immune modulating component.... Duke University

10/05/17 / #20170282214

Methods and systems for deposition of blended polymer films

Methods and systems for deposition of blended polymer films are disclosed. According to an aspect a method of producing a film on a substrate includes combining a guest material, a host matrix, and a solvent having one or more hydroxyl (O—H) bonds to form a target emulsion. The method also... Duke University

10/05/17 / #20170283872

Compositions and methods for enhancing odorant receptor activity

The present invention relates to polypeptides capable of modulating odorant receptor activation. In particular, the present invention provides polypeptides (e.g., type 3 muscarinic actetylcholine receptor M3) capable of enhancing odorant receptor activation. The present invention further provides assays for the detection of ligands specific for various odorant receptors. Additionally, the... Duke University

10/05/17 / #20170283882

Methods and therapeutics relating to mrna biomarkers for clinical prognosis of cancer

This disclosure provides methods and compositions of matter relating to the monitoring of relative concentrations of pairs of isoforms of mRNA or downstream expression products thereof. The methods can include measuring a relative expression level of a pair of mRNA isoforms or downstream expression products thereof and comparing the relative... Duke University

09/28/17 / #20170274037

Peptides for suppressing inflammation

Provided herein are peptides that exhibit ApoE biological activity, as well as compositions and pharmaceutical formulations that include the peptides. The peptides, compositions, and methods disclosed herein have broad applications as they can be used to treat a broad spectrum of injury, diseases, disorders, and clinical indications.... Duke University

09/21/17 / #20170267651

Trpa1 and trpv4 inhibitors and methods of using the same for organ-specific inflammation and itch

Provided are methods of treating and/or preventing dermatological disorders. Provided are methods of reducing skin inflammation, reducing pain, and/or reducing itch in a subject in need thereof. The methods may include administering to the subject an effective amount of a TRPA1 and/or TRPV4 inhibitor. Further provided are compositions including a... Duke University

09/14/17 / #20170259067

Non-regular electrical stimulation patterns designed with a cost function for treating neurological disorders

Systems and methods for stimulation of neurological tissue generate stimulation trains with temporal patterns of stimulation, in which the interval between electrical pulses (the inter-pulse intervals) changes or varies over time. Compared to conventional continuous, high rate pulse trains having regular (i.e., constant) inter-pulse intervals, the non-regular (i.e., not constant)... Duke University

09/14/17 / #20170260191

Kinase inhibitors and related methods of use

The present disclosure is directed to compounds that may selectively inhibit Death Associated Protein Kinases (DAPKs) as well as PIM kinases. The compounds can be used in methods of treating various disorders, including cancers.... Duke University

09/07/17 / #20170254634

Non-invasive thickness measurement using resonant frequency shift

A method of measuring thickness of a material generally includes transmitting an oscillating signal from a first pad, through the material, to a second pad, and measuring the signal reflected back to the first pad. The material may be homogenous or heterogeneous, and has dielectric properties. The signal has its... Duke University

09/07/17 / #20170254999

Multiscale telescopic imaging system

A multiscale telescopic imaging system is disclosed. The system includes an objective lens, having a wide field of view, which forms an intermediate image of a scene at a substantially spherical image surface. A plurality of microcameras in a microcamera array relay image portions of the intermediate image onto their... Duke University

08/31/17 / #20170247765

Methods for rapid and sensitive detection of hotspot mutations

Methods that rapidly, sensitively, and specifically detect mutations in IDH1/2 and the TERT promoter employ amplification of particular portions of the genes that experience frequent and exquisitely localized mutations. The ability to distinguish between sequences that differ only by one nucleotide and which may be present in very low ratios... Duke University

08/31/17 / #20170250805

Reconfigurable free-space quantum cryptography system

A system, and methods, for transmitting encrypted information as a quantum transmission between a first node and a second node, or among more than two nodes. Each node is characterized by an instantaneous spatial position, and the instantaneous spatial position of the second node is repositionable within a frame of... Duke University

08/24/17 / #20170239160

Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives

A method for treating hair loss in mammals uses compositions containing 2-decarboxy-2-phosphinico prostaglandin derivatives. The compositions can be applied topically to the skin. The compositions can arrest hair loss, reverse hair loss, and promote hair growth. Compositions containing 2-decarboxy-2-phosphinico prostaglandin derivatives can also be used to lower intraocular pressure and... Duke University

08/24/17 / #20170239352

Combination drug therapy for the treatment of solid tumors

The present invention relates to a pharmaceutical combination that comprises an IGF1R inhibitor and an mTOR inhibitor for the treatment of cancer in a subject; a pharmaceutical composition comprising such a combination; the use of such a combination for the preparation of medicament for the treatment of cancer; a kit... Duke University

08/24/17 / #20170239363

Polymer conjugates having reduced antigenicity and methods of using the same

Disclosed herein are compositions and methods for reducing the antigenicity of molecules. The antigenicity of a molecule may be reduced or eliminated by conjugating at least one branched polymer to the molecule to form a molecule-polymer conjugate. The branched polymer may include a backbone and a plurality of side chains,... Duke University

08/17/17 / #20170233714

Polymer conjugates having reduced antigenicity and methods of using the same

Disclosed herein are compositions and methods for reducing the antigenicity of molecules, wherein the molecule comprises a uricase. The antigenicity of a molecule may be reduced or eliminated by conjugating at least one branched polymer to the molecule to form a molecule-polymer conjugate. The branched polymer may include a backbone... Duke University

08/10/17 / #20170224712

Prochelators as broad-spectrum antimicrobial agents and methods of use

The present disclosure provides methods of treating (including ameliorating and/or preventing) pathogenic infections by administering a therapeutically effective amount of a prochelator. The present disclosure further provides pharmaceutical compositions and a kit comprising the prochelator therein.... Duke University

08/10/17 / #20170227553

Compositions and methods for identifying and treating conditions involving hsf1 activity

Provided herein are methods for identifying and treating subjects having conditions involving reduced HSF1 activity (e.g., diminished HSF1 activity, diminished HSF1 protein levels, increased HSF1 Ser303 phosphorylation, increased HSF1 Ser307 phosphorylation) or conditions that benefit from increasing HSF1 abundance or activity beyond physiological levels.... Duke University

08/03/17 / #20170216289

Compositions and methods for the treatment of cancer

The present disclosure provides compositions and methods for the treatment of cancer, relating to the specific inhibition of Abelson (ABL) kinases.... Duke University

08/03/17 / #20170216382

Oncolytic poliovirus for human tumors

Human clinical use of a chimeric poliovirus construct has demonstrated excellent anti-tumor effect. The mechanism of action is believed to involve both viral oncolysis as well as immune recruitment, both of which lead to necrosis in the area of the tumor. No adverse effects have been observed.... Duke University

08/03/17 / #20170216426

Compositions and methods for transient immune response modulation during vaccination

In certain aspects the invention provides a selection of HIV-1 envelopes suitable for use as immunogens, and methods of using these immunogens to induce neutralizing antibodies. In certain embodiments, the immunogens are designed to trimerize. In other embodiments, the immunogenic compositions and methods comprise at least one agent for transient... Duke University

08/03/17 / #20170216808

Programmable liquid, gel and biohybrid compartments and methods of use

Nano- to microscale liquid coacervate particles are provided. The liquid coacervate particles are produced by a process including stimulating a population of liquid droplets containing one or a mixture of components to induce a phase separation point of a first component, and maintaining stimulation at the phase separation point to... Duke University

07/27/17 / #20170212195

Magnetic resonance imaging (mri) determining and adjusting inversion time (ti) using single-line acquisition and automatic compartment detection

Magnetic resonance imaging (MRI) systems and methods for determining and adjusting TI using single-line acquisition and automatic compartment detection. A method includes positioning a readout line of the MRI scanner through a compartment of interest of a region of interest in a subject. The method includes inverting magnetization within the... Duke University

07/20/17 / #20170202823

Method of treating cancer using selective estrogen receptor modulators

Disclosed herein are methods of treating subjects suffering from estrogen receptor positive cancer of the brain by administering a selective estrogen receptor degrader (SERM). Also disclosed are methods of treating a cancer that is resistant to an estrogen receptor modulator by administering a SERM.... Duke University

Patent Packs
07/13/17 / #20170196892

Compositions and methods for the repair of myelin

Described are oxysterols, pharmaceutical compositions including the oxysterols, and methods of using the oxysterols and compositions for treating diseases and/or disorders related to myelin injury, such as neonatal brain injury, traumatic brain injury, spinal cord injury, cerebral palsy, seizures, cognitive delay, multiple sclerosis, stroke, autism, leukodystrophy, schizophrenia and bipolar disorder.... Duke University

07/13/17 / #20170196952

Vaccines against an oncogenic isoform of esr1 and methods of using the same

Methods of reducing the likelihood of a cancer or precancer developing resistance to a cancer therapeutic or prevention agent are provided herein. The methods include administering the cancer therapeutic or prevention agent and a vaccine comprising a polynucleotide encoding a polypeptide whose expression or activation is correlated with development of... Duke University

07/13/17 / #20170196953

Vaccines against an oncogenic isoform of her2 (erbb2) and methods of using the same

Methods of reducing the likelihood of a cancer or precancer developing resistance to a cancer therapeutic or prevention agent are provided herein. The methods include administering a vaccine comprising a polynucleotide encoding a polypeptide whose expression or activation is correlated with development of resistance of the cancer or precancer to... Duke University

07/13/17 / #20170196977

Methods and systems for treating cell proliferation disorders using plasmonics enhanced photospectral therapy (pepst) and exciton-plasmon enhanced phototherapy (epep)

The use of plasmonics enhanced photospectral therapy (PEPST) and exciton-plasmon enhanced phototherapy (EPEP) in the treatment of various cell proliferation disorders, the PEPST and EPEP agents and probes used therein, and pharmaceutical compositions using and/or containing the same.... Duke University

07/13/17 / #20170197206

Disposable pipette tip and methods of use

A kit for detection of an analyte of interest in a liquid sample, and methods of using, are provided. The kit may include a pipette and a disposable pipette tip configured to engage the pipette. The pipette tip may define an acoustic channel configured for allowing flow-through of a liquid.... Duke University

07/06/17 / #20170189357

Methods of limiting morbidity in hemoglobinopathies

Methods of alleviating the symptoms of hemoglobinopathies, including, but not limited to, sickle cell disease, β-thalassemia, and hemoglobin H disease are provided. In some embodiments, the methods comprise administering an agent to the subject if the subject has increased expression or activation of at least one of ERK, Ras, BRAF,... Duke University

07/06/17 / #20170189559

Contrast agents for magnetic resonance imaging

Ascorbate or a pharmaceutically acceptable salt thereof is described for use in carrying out a method, or for the preparation of a medicament for carrying out a method, of enhancing a magnetic resonance imaging (MRI) image of a body or body region such as an organ or organ region in... Duke University

07/06/17 / #20170189561

Ascorbate formulations and methods of use as contrast agents

A sterile aqueous composition suitable for use as an MRI contrast agent includes 100 to 600 mM ascorbate; and 100-600 mM sodium, meglumine, or a combination thereof. The composition preferably has an osmolarity of 200 to 1400 mOsm/L.... Duke University

07/06/17 / #20170189562

Metal complexes with bisphosphonate or pyrophosphate useful as imaging agents

Provided herein are magnetic resonance imaging (MRI) contrast agents comprising a compound having a structure represented by: Y—X—Z, wherein, X is: Fe(III) or Mn(II), and Y and Z are each independently selected from pyrophosphate and bisphosphonate (e.g., 1-hydroxybisphosphonate), or a pharmaceutically acceptable hydrate and/or salt thereof. Methods of use of... Duke University

07/06/17 / #20170190675

Chemical modulators of immune checkpoints and therapeutic use

Compounds and pharmaceutical compositions that down-regulate immune checkpoints such as PD-1, PD-L1 and CTLA-4 are provided. Also provided are methods of treating a disease by down-regulating immune checkpoints such as PD-1, PD-L1 and CTLA-4. The methods are useful for treating cancer and viral infection in a subject.... Duke University

06/29/17 / #20170182322

Systems and methods for spinal cord stimulation

Optimizing temporal pulse patterns for stimulation delivery to a subject includes: generating a first generation pulse pattern; delivering stimulation according to the first generation pattern to a subject; measuring efficacy, efficiency and side-effect parameters affected by the delivered stimulation; determining a fitness of the first generation pattern using the measured... Duke University

06/29/17 / #20170184729

Linear-response nanocrystal scintillators and methods of using the same

Systems and devices incorporating radiation detection, and techniques and materials for improved radiation detection are provided that involve a nano-scintillator exhibiting a linear luminescent emission response to stimulating electromagnetic radiation. The nano-scintillator can include at least one nanocrystal comprising a rare earth element, a lanthanide dopant, and a spectator dopant,... Duke University

06/29/17 / #20170186195

Spectral estimation and poly-energetic reconstruction methods and x-ray systems

Spectral estimation and poly-energetic reconstructions methods and x-ray systems are disclosed. According to an aspect, a spectral estimation method includes using multiple, poly-energetic x-ray sources to generate x-rays and to direct the x-rays towards a target object. The method also includes acquiring a series of poly-energetic measurements of x-rays from... Duke University

06/22/17 / #20170173252

Arteriovenous graft for hemodialysis with puncture-resistant posterior and side walls

An arteriovenous dialysis access graft configured to be implanted in a subject includes: at least one flexible conduit having first and second end portions, wherein the first end portion is configured to connect to an artery of the subject and the second end portion is configured to connect to a... Duke University

06/22/17 / #20170173350

Plasmonic assisted interior energy-activation from an exterior source

A method and a system for producing a change in a medium disposed in an artificial container. The method places in a vicinity of the medium at least one of a plasmonics agent and an energy modulation agent. The method applies an initiation energy through the artificial container to the... Duke University

Patent Packs
06/22/17 / #20170174660

Heat shock protein 70 (hsp-70) receptor ligands

Inducible HSP70 is overexpressed in a wide spectrum of human tumors and its expression correlates with metastasis and poor outcomes to radiation and chemotherapy in patients. Identification of small molecule inhibitors of HSP70 pose a new therapy to cancer treatment. HS72, a benzimidazole piperidinyl carboxamide has been identified as an... Duke University

06/22/17 / #20170176559

Systems and methods for assessing pulmonary gas transfer using hyperpolarized 129xe mri

Methods and systems for assessing pulmonary gas exchange and/or alveolar-capillary barrier status include obtaining at least one MRI image and/or image data of 129Xe dissolved in the red blood cells (RBC) in the gas exchange regions of the lungs of a patient. The image is sufficiently sensitive to allow a... Duke University

06/15/17 / #20170165216

Methods and compositions for treatment of acute lung injury

A method of treating acute lung injury (ALI) in a patient suspected of having ALI is disclosed. The method includes administering to the patient a therapeutically effective amount of an inducible nitric oxide synthase (iNOS) inhibitor.... Duke University

06/15/17 / #20170165316

Method of reducing titers of antibodies specific for a therapeutic agent

The present invention relates, in general, to a method of treating patients undergoing enzyme replacement therapy (ERT) or other therapy involving the administration of a proteinaceous therapeutic agent as well gene replacement therapy with non-viral or viral vectors, or other therapeutic modality or modalities, used alone or in combination, which... Duke University

06/15/17 / #20170166977

Biomarkers for the identification of prostate cancer and methods of use

The present disclosure provides biomarkers for the identification of prostate cancer and methods of use. The present disclosure also provide biomarkers that can be used for determining risk of developing prostate cancer, aggressiveness of prostate cancer and survival rate for subpopulations of African American males or non-Hispanic white males.... Duke University

06/08/17 / #20170157218

Methods of treating fragile x syndrome and related disorders

Disclosed herein are novel methodologies of treating fragile X syndrome and related disorders by inhibiting mG1u5-relevant signaling pathways via the reduction of β-arrestin2 protein levels or the diminution of mG1u5 and β-arrestin2 protein interactions.... Duke University

06/08/17 / #20170157418

X-ray psoralen activated cancer therapy (x-pact)

A system for treating a diseased site in a human or animal body. The system includes a pharmaceutical carrier including one or more phosphors which are capable of emitting light into the diseased site upon interaction, a photoactivatable drug for intercalating into DNA of cells at the diseased site, one... Duke University

06/08/17 / #20170161454

Systems and methods for model-based optimization of spinal cord stimulation electrodes and devices

Systems and methods for model-based optimization of spinal cord stimulation electrodes and devices are disclosed. According to an aspect a method includes providing a patient-specific electroanatomical model including the spine, spinal cord, and a map of target neural elements and non-target neural elements. The method also includes using model electrodes... Duke University

06/08/17 / #20170162537

Adhesive bonding composition and wafer-to-wafer bonded assembly prepared from the same

A polymerizable composition includes at least one monomer, a photoinitiator capable of initiating polymerization of the monomer when exposed to light, and a phosphor capable of producing light when exposed to radiation (typically X-rays). The material is particularly suitable for bonding components at ambient temperature in situations where the bond... Duke University

06/01/17 / #20170151331

Nanostars and nanoconstructs for detection, imaging, and therapy

A polymer-free synthesis method is provided for preparation of monodisperse nanostars. The nanostars can be used for treating and imaging cells in in vivo or ex vivo. The modes of treatment include use of a nanostar modified with a photo-activatable drug, which drug is activated by the photo-response of the... Duke University

05/18/17 / #20170138967

Metabolics biomarker for nafld and methods of use

The present disclosure provides metabolomics biomarkers for NAFLD and indicative of liver fibrosis and methods of using same.... Duke University

05/18/17 / #20170140544

Segmentation and identification of layered structures in images

Disclosed herein are systems and method for segmentation and identification of structured features in images. According to an aspect, a method may include representing an image as a graph of nodes connected together by edges. For example, the image may be an ocular image showing layered structures or other features... Duke University

05/11/17 / #20170127938

Systems and methods for obtaining low-angle circumferential optical access to the eye

A system for obtaining low-angle circumferential optical access to an eye of a subject. The system includes a light source to generate a beam of light; a beam steering mechanism to steer the beam of light a focusing lens to focus the beam of light; and a contact lens to... Duke University

05/11/17 / #20170128526

Stem cell derived factors for treating pathologic conditions

A purified paracrine factor of a mesenchymal stem cell, such as a Secreted frizzled related protein (Sfrp) is useful to reduce cell death an/or tissue injury associated with ischemic conditions.... Duke University

05/11/17 / #20170132804

System and improved computational imaging

A system and method for computing a digital image of a scene, where the digital image contains enhanced depth information are disclosed. Embodiments of the present invention form a light distribution on a focal-plane array, where the light distribution is based on an optical image of the scene formed by... Duke University

05/04/17 / #20170121472

Plasmonic assisted interior energy-activation from an exterior source

A method and a system for producing a change in a medium disposed in an artificial container. The method places in a vicinity of the medium at least one of a plasmonics agent and an energy modulation agent. The method applies an initiation energy through the artificial container to the... Duke University

05/04/17 / #20170121707

Compositions and methods for rapid and dynamic flux control using synthetic metabolic valves

This invention relates to metabolically engineered microorganisms, such as bacterial and or fungal strains, and bioprocesses utilizing such strains. These strains enable the dynamic control of metabolic pathways, which can be used to optimize production. Dynamic control over metabolism is accomplished via a combination of methodologies including but not limited... Duke University

04/27/17 / #20170113061

Methods and systems for treating cell proliferation disorders with psoralen derivatives

Psoralen compounds of compounds having formulae 1A-10A, 1B-10B, 1C-10C, 1D-10D, 1E-10E, 1F-10F, 1G-10G, and 1H-5H as shown in FIG. 1, and pharmaceutically acceptable salts thereof; and their use in methods for the treatment of a cell proliferation disorder in a subject, pharmaceutical compositions containing the psoralen derivatives, a kit for... Duke University

04/27/17 / #20170115293

Methods for predicting the radiosensitivity of a cancer tumor and methods of treating cancer

Methods for predicting the radiosensitivity of a cancer tumor and treating cancer in a subject are provided. In another aspect, methods of treating cancer in a subject are also provided. The methods may include administering to the subject radiation therapy based on the expression level of no more than 35,... Duke University

04/20/17 / #20170106080

Liposome-peptide conjugate and using same to induce production of anti-hiv antibodies

The present invention relates, in general, to human immunodeficiency virus (HIV), and, in particular, to a method of inducing neutralizing antibodies to HIV and to compounds and compositions suitable for use in such a method.... Duke University

04/20/17 / #20170107197

Phenyl-substituted nicotinic ligands, and methods of use thereof

Disclosed are compounds and methods of using them to treat a disorder selected from the group consisting of addiction, pain, obesity, schizophrenia, epilepsy, mania and manic depression, anxiety, Alzheimer's disease, learning deficit, cognition deficit, attention deficit, memory loss, Lewy Body Dementia, Attention Deficit Hyperactivity Disorder (ADHD), Parkinson's disease, Huntington's disease,... Duke University

04/20/17 / #20170107260

Mosaic hiv-1 sequences and uses thereof

The invention is directed to mosaic HIV 1 genes designed to induce T-cell responses.... Duke University








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