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Duke University patents


Recent patent applications related to Duke University. Duke University is listed as an Agent/Assignee. Note: Duke University may have other listings under different names/spellings. We're not affiliated with Duke University, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "D" | Duke University-related inventors


Modulating the aryl hydrocarbon receptor system to treat major depressive disorder

Materials and methods for treating major depressive disorder by modulating the aryl hydrocarbon receptor system are provided herein.... Duke University

Systems and methods for determining viscoelastic properties in soft tissue using ultrasound

Systems and methods for determining viscoelastic properties in soft tissue using ultrasound are disclosed. According to an aspect, a method includes using an ultrasound probe to acquire soft tissue data. The method also includes determining a first group shear wave speed having a first frequency spectra. Further, the method includes... Duke University

Lasofoxifene treatment of breast cancer

The disclosure provides methods for treating estrogen receptor positive (ER+) cancer in women with an effective amount of lasofoxifene, a pharmaceutically acceptable salt thereof, or a prodrug thereof. The disclosure also includes the detection of the Estrogen Receptor 1 (ESR1) gene mutations that lead to endocrine resistance and treatment of... Duke University

Lymph node-targeting nanoparticles

Provided are nanoparticles comprising heparin, chitosan, and at least one immunomodulatory agent, e.g. a cytokine. The cytokine can be selected from the group consisting of TNF, IL-12, IL-2, IL-23, IL-1α, IL-10, IL-18, and combinations thereof. Further provided are methods of making a nanoparticle comprising mixing a first composition comprising heparin... Duke University

Mitochondrial antiviral signaling (mavs) protein compositions and methods of using the same

The invention generally relates to compositions and methods for preventing and treating cancer. More specifically, the invention relates to MAVS compositions and their use in cancer therapeutics that may be used to treat various cancers alone or in combination with other anti-cancer therapeutic agents.... Duke University

Vaccines against her3 antigens and methods of using the same

The invention generally relates to compositions and methods for preventing and treating cancer. More specifically, the invention relates to antigenic polypeptides and their use in cancer vaccines that may be used, in part, to treat cancer types dependent upon HER2-mediated signaling.... Duke University

Compositions and methods for the induction and tuning of gene expression

Disclosed herein are compositions of transcription activator-like effectors transcription factors and methods of using said compositions for inducing gene expression of mammalian genes.... Duke University

Software-based self-test and diagnosis using on-chip memory

Embedded processor-based self-test and diagnosis using the compressed test data is described for ICs having on-chip memory. Techniques for compressing the test data before the compressed test data is transferred to a device under test (DUT) are also described. A modified LZ77 algorithm can be used to compress strings of... Duke University

Software-based self-test and diagnosis using on-chip memory

Embedded processor-based self-test and diagnosis using the compressed test data is described for ICs having on-chip memory. Techniques for compressing the test data before the compressed test data is transferred to a device under test (DUT) are also described. A modified LZ77 algorithm can be used to compress strings of... Duke University

Hiv-1 neutralizing antibodies and uses thereof (cd4bs antibodies)

The invention relates to the identification of monoclonal HIV-1 neutralizing antibodies, such as, but not limited to, antibodies that bind to the CD4 binding site (CD4bs) of HIV-1 gp120, their recombinant expression and purification and uses. In certain aspects, the invention provides a pharmaceutical composition comprising anyone of the antibodies... Duke University

Contrast agents for magnetic resonance imaging

Ascorbate or a pharmaceutically acceptable salt thereof is described for use in carrying out a method, or for the preparation of a medicament for carrying out a method, of enhancing a magnetic resonance imaging (MRI) image of a body or body region such as an organ or organ region in... Duke University

Hiv-1 neutralizing antibodies and uses thereof (v3 antibodies)

The invention is directed to HIV-1 neutralizing antibodies, CD4 binding site and V3 glycan antibodies, and methods for their uses.... Duke University

Method of treating glycogen storage disease

The disclosure relates, in general, to Glycogen Storage Disease and, in particular, to a method of treating Glycogen Storage Disease and to compounds and compositions suitable for use in such a method.... Duke University

Systems and methods for spinal cord stimulation

Delivering stimulation includes delivering temporal patterns of stimulation pulses to respective transducers of an array of transducers, wherein the delivery of the pattern to a particular transducer of the array is different from at least some of the deliveries of the patterns to the other transducers of the array at... Duke University

Non-regular electrical stimulation patterns for improved efficiency in treating parkinson's disease

Systems and methods for stimulation of neurological tissue generate stimulation trains with temporal patterns of stimulation, in which the interval between electrical pulses (the inter-pulse intervals) changes or varies over time. Compared to conventional continuous, high rate pulse trains having regular (i.e., constant) inter-pulse intervals, the non-regular (i.e., not constant)... Duke University

Compositions and methods for identifying and modulating metabolic health

This invention provides reagents, methods and biochemical markers for identifying and providing therapeutic intervention for individuals with metabolic dysfunction, or individuals at risk for metabolic dysfunction.... Duke University

Compositions and methods for metabolic profiling in subjects with heart failure with preserved ejection fraction

Disclosed herein are compositions and methods for targeted metabolomics profiling to provide absolute quantification of a broad array of metabolic intermediates of fatty acids, amino acids, and carbohydrate metabolism for HFpEF. In an aspect, the disclosure relates to a method for assessing risk of death or a major adverse cardiac... Duke University

Metamaterials for surfaces and waveguides

Complementary metamaterial elements provide an effective permittivity and/or permeability for surface structures and/or waveguide structures. The complementary metamaterial resonant elements may include Babinet complements of “split ring resonator” (SRR) and “electric LC” (ELC) metamaterial elements. In some approaches, the complementary metamaterial elements are embedded in the bounding surfaces of planar... Duke University

Plasmonics-active metal nanostar compositions and methods of use

Plasmonics-active metal nanostars are provided that can be used for treating and detecting cells in a subject. The modes of treatment include a photo-activated drug, which is activated by the photo-response of the nanostar to electromagnetic stimulation; a thermally-activated drug, which is activated by a thermal response of the nanostar... Duke University

Compositions and methods for the reprogramming of cells into cardiomyocytes

The present disclosure provides compositions and methods for the reprogramming of cells such as fibroblasts into cardiomyocytes. The invention provided herein features a chemically defined media and methods of reprogramming cells to increase cardiac gene and protein expression in cardiac fibroblasts and other fibroblasts, e.g. dermal fibroblasts. The media and... Duke University

Systems and methods for automated radiation treatment planning with decision support

Systems and methods for automated radiation treatment planning with decision support are disclosed. According to an aspect, a method includes receiving data based on patient information and geometric characterization of one or more organs at risk and a cancer target of a patient. The method also includes determining the appropriate... Duke University

Automatic determination of radiation beam configurations for patient-specific radiation therapy planning

Systems and methods for efficient and automatic determination of radiation beam configurations for patient-specific radiation therapy planning are disclosed. According to an aspect, a method includes receiving data based on patient information and geometric characterization of one or more organs at risk proximate to a target volume of a patient.... Duke University

Biomarker based prognostic model for predicting overall survival in patients with metastatic clear cell kidney cancer

The present invention describes a method of using a molecular prognostic signature, to predict overall survival in patients with metastatic clear cell renal cell carcinoma. The present invention also describes a method of selecting therapy and a process for patient risk stratification based on the molecular prognostic signature analysis.... Duke University

Electromagnetic (em) well logging tools and related methods

An electromagnetic well logging tool for a wireline logging process, includes a shaft, a transmitter coil mounted on the shaft and configured to generate primary magnetic fields for propagation into a well formation, upon excitation by a first current, a receiver coil mounted on the shaft at a predefined distance... Duke University

Double engineered hiv-1 envelopes

In certain aspects the invention provides HIV-1 engineered envelope proteins and their uses. The engineered envelopes comprise a sequence that prevents cleavage of the envelope associated with recombinant expression in a cell line, and N-terminal deletion which improves envelope expression as a monomer.... Duke University

Advanced methods and systems for treating cell proliferation disorders

wherein the plasmonics-active agent enhances or modifies the applied initiation energy, such that the enhanced or modified initiation energy activates the activatable pharmaceutical agent by the simultaneous two photon absorption event in situ, thus causing the predetermined cellular change to occur, wherein said predetermined cellular change treats the cell proliferation... Duke University

Phase transition biopolymers and methods of use

The present disclosure describes environmentally responsive polypeptides capable of displaying stimuli-triggered conformational changes in a reversible or irreversible manner that may be accompanied by aggregation. Polypeptides include a number of repeated motifs and may be elastomeric or non-elastomeric. The polypeptides may be used to deliver therapeutics to a biological site... Duke University

Glucose/galactose biosensors and methods of using same

Provided herein are glucose and galactose biosensors and methods of making and using the same.... Duke University

Electromagnetic cloaking method

A method of constructing a concealing volume comprises constructing a plurality of concealing volume elements around a concealable volume. Each concealing volume element has a material parameter arranged to direct a propagating wave around the concealable volume. The material parameter can be refractive index, electrical permittivity, and magnetic permittivity. The... Duke University

Activation of trpv4 ion channel by physical stimuli and critical role for trpv4 in organ-specific inflammation and itch

Provided are methods of treating and/or preventing dermatological disorders. Provided are methods of reducing skin inflammation, reducing pain, and/or reducing itch in a subject in need thereof. The methods may include administering to the subject an effective amount of a TRPV4 inhibitor. Further provided are compositions including a TRPV4 inhibitor... Duke University

Compositions and methods for epigenome editing

Disclosed herein are CRISPR/Cas9-based gene activation systems that include a fusion protein of a Cas9 protein and a protein having histone acetyltransferase activity, and methods of using said systems.... Duke University

Fusion molecules of rationally-designed dna-binding proteins and effector domains

Targeted transcriptional effectors (transcription activators and transcription repressors) derived from meganucleases are described. Also described are nucleic acids encoding same, and methods of using same to regulate gene expression. The targeted transcriptional effectors can comprise (i) a meganuclease DNA-binding domain lacking endonuclease cleavage activity that binds to a target recognition... Duke University

Stereoscopic display displaying surgical data and information in a surgical microscope

Stereoscopic display systems and methods for displaying surgical data and information in a surgical microscope are disclosed herein. According to an aspect, a system includes first and second eyepieces. The system includes a display having first and second display portions, configured to display first images in the first display portion,... Duke University

Systems and methods for endoscopic angle-resolved low coherence interferometry

A method of assessing tissue health comprises the steps of obtaining depth-resolved spectra of a selected area of in vivo tissue, and assessing the health of the selected area based on the depth-resolved structural information of the scatterers. Obtaining depth-resolved spectra of the selected area comprises directing a sample beam... Duke University

Compositions for the sustained release of anti-glaucoma agents to control intraocular pressure

Controlled release dosage formulations for the delivery of active agents, especially for treatment of eye diseases or disorders, such as glaucoma, have been developed. These provide release of the active agent, such as ECA or a derivative thereof, for an effective period of time.... Duke University

01/04/18 / #20180001472

Specialized robot motion planning hardware and methods of making and using same

Specialized robot motion planning hardware and methods of making and using same are provided. A robot-specific hardware can be designed using a tool that receives a robot description comprising a collision geometry of a robot, degrees of freedom for each joint of the robot, and joint limits of the robot;... Duke University

12/28/17 / #20170368050

Compositions and methods for the prevention and treatment of mast cell-induced vascular leakage

Disclosed herein are methods of diagnosing and treating infectious disease characterized by a pathology that involves hemorrhaging or pathological vascular leakage.... Duke University

12/28/17 / #20170369491

Compounds and methods for targeting hsp90

Described herein are compounds that may selectively bind to Hsp90, methods of using the compounds, and kits including the compounds. The compounds may include detection moieties such as fluorophores that may allow for selective detection of Hsp90 in a sample.... Duke University

12/21/17 / #20170360946

Enzyme-catalyzed synthesis of site-specific and stoichiometric biomolecule-polymer conjugates

Methods for producing polypeptide-polymer conjugates include attachment of an initiator agent to a polypeptide specifically at the C-terminus of the polypeptide using a sortase enzyme and in situ polymerization of a polymer from the C-terminus. The polypeptide-polymer conjugates may have desirable pharmacological properties and may be used therapeutically.... Duke University

12/14/17 / #20170355992

Factor v/va-targeting aptamer compositons and methods of using the same

Provided herein are Factor V/Factor Va-targeting aptamer compositions and antidote compositions targeting such aptamer compositions. Methods for preventing blood clots using such compositions are also provided.... Duke University

12/14/17 / #20170357139

Apparatus and providing a selectively absorbing structure

An apparatus is described that selectively absorbs electromagnetic radiation. The apparatus includes a conducting surface, a dielectric layer formed on the conducting surface, and a plurality of conducting particles distributed on the dielectric layer. The dielectric layer can be formed from a material and a thickness selected to yield a... Duke University

12/07/17 / #20170348214

Compositions and methods for treating hair loss using non-naturally occurring prostaglandins

A method for treating hair loss in mammals uses compositions containing prostaglandin F analogs. The compositions can be applied topically to the skin. The compositions can arrest hair loss, reverse hair loss, and promote hair growth.... Duke University

12/07/17 / #20170348531

Non-regular electrical stimulation patterns for treating neurological disorders

Systems and methods for stimulation of neurological tissue generate stimulation trains with temporal patterns of stimulation, in which the interval between electrical pulses (the inter-pulse intervals) changes or varies over time. Compared to conventional continuous, high rate pulse trains having regular (i.e., constant) inter-pulse intervals, the non-regular (i.e., not constant)... Duke University

12/07/17 / #20170349544

Ethynylbenzene derivatives

Disclosed are compounds of formulae (I), (II), and (II)I: and pharmaceutically acceptable salts thereof, wherein the variables, R, R1, R2, R3, R101, L, D, Q, Y, X, and Z are defined herein. These compounds are useful for treating Gram-negative bacteria infections.... Duke University

11/30/17 / #20170343603

Multi-layer integrated circuits having isolation cells for layer testing and related methods

Multi-layer integrated circuits having isolation cells for layer testing and related methods are disclosed. According to an aspect, an integrated circuit includes first and second layers that each have one or more electronic components. One or more electronic components of each layer can be electrically connected by a first via... Duke University

11/30/17 / #20170347460

Stretchable electrically conductive layer formation by aerosol jet printing on flexible substrate

Methods of forming an electrically conductive layer on a flexible substrate, such as a stretchable electrode, by aerosol jet printing on the flexible substrate while the substrate is strained. In general, a stretchable substrate is initially deformed so that a first surface thereof is under tension. While the substrate is... Duke University

11/23/17 / #20170332939

Self-gated interleaved radial mri for abdominothoracic imaging

The present disclosure provides, in part, methods for high spatiotemporal resolution self-sorted 4D MRI. These methods can be used to improve resolution of abdominothoracic MRI during breathing by facilitating the sorting of information corresponding to individual MRI pulse sequences according to phase within the respiratory cycle. An image of the... Duke University

11/23/17 / #20170333356

Treatment method and product for uterine fibroids using purified collagenase

The invention relates to compositions and methods for treating uterine fibroids, wherein a uterine fibroid treatment agent comprising collagenase in an amount effective to cause shrinkage of uterine fibroids is injected or inserted into the uterine fibroid.... Duke University

11/23/17 / #20170335299

Rationally-designed meganucleases with altered sequence specificity and dna-binding affinity

Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment... Duke University

11/16/17 / #20170326127

Composition and treatment of neuropsychiatric disorders

The present invention relates to a composition and method for combinative therapy, capable of temporarily regulating inherent dysfunctional neural processes and reducing symptoms and/or signs of neuropsychiatric disorders including, but not limited to, psychostimulant use disorder (PUD) and other substance-related additive disorders, post-traumatic stress disorder (PTSD) and other trauma- and... Duke University

11/16/17 / #20170326199

Use of caspase-2 inhibitors to treat and prevent the metabolic syndrome

Methods and compositions for treatment of obesity, insulin resistance, hyperinsulinemia, type 2 diabetes mellitus, dyslipidemia, and nonalcoholic fatty liver disease are discloses. The methods and compositions relate to inhibition of caspase-2.... Duke University

11/16/17 / #20170326229

Swarm immunization with 54 envelopes from ch505

In certain aspects the invention provides HIV-1 immunogens, including envelopes (CH505) and selections therefrom, and methods for swami immunizations using combinations of HIV-1 envelopes.... Duke University

11/16/17 / #20170326258

Contrast agents based on long-lived nuclear singlet states and related methods

Methods are described for preparing magnetic resonance imaging (MRI) and/or magnetic resonance spectroscopy contrast agents where the contrast agents are prepared from precursor molecules having at least four non-zero-spin nuclei that form two pairs of chemically equivalent or effectively equivalent nuclei, e.g., diphenylacetylene or diethyl oxalate. The precursor molecule is... Duke University

11/16/17 / #20170327866

Methods for in vivo identification of endogenous mrna targets of micrornas

A method of generating a gene expression profile of noncoding regulatory RNA (ncRNA; e.g. a microRNA) in a cell in vivo, is carried out by: (a) partitioning from a cell at least one mRNA-protein (RNP) complex, the RNP complex comprising: (i) an RNA binding protein (RNABP) or RNA associated protein,... Duke University

11/09/17 / #20170319591

Methods of treating hemoglobinopathies

Methods of alleviating the symptoms of hemoglobinopathies, including, but not limited to, sickle cell disease, β-thalassemia, and hemoglobin H disease are provided. In some embodiments, the methods comprise administering an inhibitor selected from an ERK inhibitor, a MEK inhibitor, and, a Raf inhibitor. Methods of inhibiting adhesion of sickle red... Duke University

11/09/17 / #20170319868

Phosphors and scintillators for light stimulation within a medium

A system and method for light stimulation within a medium. The system has a reduced-voltage x-ray source configured to generate x-rays from a peak applied cathode voltage at or below 105 kVp, and a plurality of energy-emitting particles in the medium which, upon radiation from the x-ray source, radiate at... Duke University

11/09/17 / #20170321280

Nano-plasmonic molecular probes for plasmonics coupling interference

Plasmonics-active nanoprobes are provided for detection of target biomolecules including nucleic acids, proteins, and small molecules. The nucleic acids that can be detected include RNA, DNA, mRNA, microRNA, and small nucleotide polymorphisms (SNPs). The nanoproprobes can be used in vito in sensitive detection methods for diagnosis of diseases and disorders... Duke University

11/09/17 / #20170322209

Biosensor

Biosensors are made by attaching covalently or non-covalently at least one reporter group to one or more specific positions of a bacterial periplasmic binding protein (bPBP). Upon binding of ligand to the biosensor, there is a change in the signal transduced by the reporter group.... Duke University

11/09/17 / #20170322273

Magnetic resonance imaging of neuro-electro-magnetic oscillations

In vivo methods of non-invasively imaging neuro-electro-magnetic oscillations (NEMO) are carried out by electronically transmitting a pulse sequence to a subject. The pulse sequence has a first excitation pulse, typically applied along an x-axis, followed by a spin-lock pulse applied along a different axis, typically a y-axis, and having a... Duke University

11/02/17 / #20170311797

Whole eye optical coherence tomography(oct) imaging systems and related methods

Whole eye optical coherence tomography (OCT) imaging systems and related methods are disclosed. According to an aspect, an OCT imaging system includes a source having an associated source arm path. Further, the OCT imaging system includes a reference arm coupled to the source arm. Further, the OCT imaging system includes... Duke University

11/02/17 / #20170312303

Compositions comprising ch848 envelopes and uses thereof

In certain aspects the invention provides immonogenic compositions comprising CH848 HIV-1 envelopes and their use in methods to induce immune responses in subjects, e.g., human subjects.... Duke University

11/02/17 / #20170312527

Waveform shapes for treating neurological disorders optimized for energy efficiency

Systems and methods for stimulation of neurological tissue apply a stimulation waveform that is derived by a developed genetic algorithm (GA), which may be coupled to a computational model of extracellular stimulation of a mammalian myelinated axon. The waveform is optimized for energy efficiency.... Duke University

10/26/17 / #20170303820

Systems, compositions and devices for in vivo magnetic resonance imaging of lungs using perfluorinated gas mixtures

Systems and methods for generating MRI images of the lungs and/or airways of a subject using a medical grade gas mixture comprises between about 20-79% inert perfluorinated gas and oxygen gas. The images are generated using acquired 19F magnetic resonance image (MRI) signal data associated with the perfluorinated gas and... Duke University

10/26/17 / #20170304162

Compositions, the encapsulation and delivery of a substance

A composition and method is provided for synthesizing silicone particles with narrow size distributions and tunable degrees of crosslinking for encapsulation of an active ingredient or multiple active ingredients in the matrix of the particles for controlled release. The method comprises agitating at least one type of silane monomer having... Duke University

10/26/17 / #20170304488

Compositions and methods for the prevention and/or reduction of scarring

The present disclosure provides methods of preventing and/or reducing scar contraction by utilizing an electrospun biocompatible scaffold.... Duke University

Patent Packs
10/26/17 / #20170304652

Systems and methods for the verification of source placement for brachytherapy radiation procedures using real time radiation detectors

The present disclosure provides systems and methods for verifying radiation source delivery in brachytherapy by allowing for the radiation source location and dwell time to be determined via real-time measurement. In an embodiment, a radiation detector may be disposed proximate to a radiotherapy target. The radiation detector is configured to... Duke University

10/26/17 / #20170306321

Systems and methods for genetic analysis of intractable microbes

Embodiments of the present disclosure relate generally to the genetic analysis of intractable microbes. More particularly, the present disclosure provides materials and methods that incorporate chemical mutagenesis, phenotypic selection, suppression analysis, and genomic sequencing-based mutational mapping, to identify novel genetic regulators in previously intractable organisms, such as microbes that constitute... Duke University

10/26/17 / #20170307349

Non-invasive thickness measurement using capacitance measurement

Methods of measuring thickness of a material using cross-capacitance. The method generally includes applying a time-varying signal to a first pad and monitoring a response of a capacitor formed by the first pad, a spaced apart second pad, and the material. The pads may be permanently affixed to the material,... Duke University

10/19/17 / #20170298331

Genetic correction of mutated genes

Disclosed herein are transcription activator-like effector nuclease (TALEN)-related compositions and methods of using said TALENs for correcting mutant genes.... Duke University

10/19/17 / #20170299655

Signal tracing using on-chip memory for in-system post-fabrication debug

A post-fabrication debug and on-line error checking framework for 2D- and 3D-ICs with integrated memories is described. A design-for-debug (DfD) architecture can include, for an IC with on-chip memory, a debug module connected to a functional bus of the IC. The debug module receives trace data for an interval, generates... Duke University

10/19/17 / #20170299784

Nanopatch antennas and related methods for tailoring the properties of optical materials and metasurfaces

Nanopatch antennas and related methods for enhancing and tailoring are disclosed. According to an aspect, an apparatus includes a conductive material defining a substantially planar surface. The apparatus also includes a conductive nanostructure defining a substantially planar surface. The conductive material and the conductive nanostructure are positioned such that the... Duke University

10/12/17 / #20170290650

Implantable mesh and use

An implantable mesh for use in reconstructing tissue includes a mesh body and one or more extensions extending from the mesh body. Each mesh extension has a first end and a second end, wherein the first end of the mesh extension is integrated into or part of the mesh body.... Duke University

10/12/17 / #20170294248

Noble metal-coated nanostructures and related methods

Noble metal-coated nanostructures and related methods are disclosed. According to an aspect, a nanostructure may include a structure comprising a base metal. As an example, the structure may be a nanowire. In a more specific example, the structure may be a copper nanowire or a nanowire made of a base... Duke University

10/05/17 / #20170281749

Compositions comprising ch505 envelopes, and trimers

In certain aspects the invention provides a selection of HIV-1 envelopes suitable for use as immunogens, and methods of using these immunogens to induce neutralizing antibodies. In certain embodiments, the immunogens are designed to trimerize. In other embodiments, the immunogens comprise an immune modulating component.... Duke University

10/05/17 / #20170282214

Methods and systems for deposition of blended polymer films

Methods and systems for deposition of blended polymer films are disclosed. According to an aspect a method of producing a film on a substrate includes combining a guest material, a host matrix, and a solvent having one or more hydroxyl (O—H) bonds to form a target emulsion. The method also... Duke University

10/05/17 / #20170283872

Compositions and methods for enhancing odorant receptor activity

The present invention relates to polypeptides capable of modulating odorant receptor activation. In particular, the present invention provides polypeptides (e.g., type 3 muscarinic actetylcholine receptor M3) capable of enhancing odorant receptor activation. The present invention further provides assays for the detection of ligands specific for various odorant receptors. Additionally, the... Duke University

10/05/17 / #20170283882

Methods and therapeutics relating to mrna biomarkers for clinical prognosis of cancer

This disclosure provides methods and compositions of matter relating to the monitoring of relative concentrations of pairs of isoforms of mRNA or downstream expression products thereof. The methods can include measuring a relative expression level of a pair of mRNA isoforms or downstream expression products thereof and comparing the relative... Duke University

09/28/17 / #20170274037

Peptides for suppressing inflammation

Provided herein are peptides that exhibit ApoE biological activity, as well as compositions and pharmaceutical formulations that include the peptides. The peptides, compositions, and methods disclosed herein have broad applications as they can be used to treat a broad spectrum of injury, diseases, disorders, and clinical indications.... Duke University

09/21/17 / #20170267651

Trpa1 and trpv4 inhibitors and methods of using the same for organ-specific inflammation and itch

Provided are methods of treating and/or preventing dermatological disorders. Provided are methods of reducing skin inflammation, reducing pain, and/or reducing itch in a subject in need thereof. The methods may include administering to the subject an effective amount of a TRPA1 and/or TRPV4 inhibitor. Further provided are compositions including a... Duke University

09/14/17 / #20170259067

Non-regular electrical stimulation patterns designed with a cost function for treating neurological disorders

Systems and methods for stimulation of neurological tissue generate stimulation trains with temporal patterns of stimulation, in which the interval between electrical pulses (the inter-pulse intervals) changes or varies over time. Compared to conventional continuous, high rate pulse trains having regular (i.e., constant) inter-pulse intervals, the non-regular (i.e., not constant)... Duke University

Patent Packs
09/14/17 / #20170260191

Kinase inhibitors and related methods of use

The present disclosure is directed to compounds that may selectively inhibit Death Associated Protein Kinases (DAPKs) as well as PIM kinases. The compounds can be used in methods of treating various disorders, including cancers.... Duke University

09/07/17 / #20170254634

Non-invasive thickness measurement using resonant frequency shift

A method of measuring thickness of a material generally includes transmitting an oscillating signal from a first pad, through the material, to a second pad, and measuring the signal reflected back to the first pad. The material may be homogenous or heterogeneous, and has dielectric properties. The signal has its... Duke University

09/07/17 / #20170254999

Multiscale telescopic imaging system

A multiscale telescopic imaging system is disclosed. The system includes an objective lens, having a wide field of view, which forms an intermediate image of a scene at a substantially spherical image surface. A plurality of microcameras in a microcamera array relay image portions of the intermediate image onto their... Duke University

08/31/17 / #20170247765

Methods for rapid and sensitive detection of hotspot mutations

Methods that rapidly, sensitively, and specifically detect mutations in IDH1/2 and the TERT promoter employ amplification of particular portions of the genes that experience frequent and exquisitely localized mutations. The ability to distinguish between sequences that differ only by one nucleotide and which may be present in very low ratios... Duke University

08/31/17 / #20170250805

Reconfigurable free-space quantum cryptography system

A system, and methods, for transmitting encrypted information as a quantum transmission between a first node and a second node, or among more than two nodes. Each node is characterized by an instantaneous spatial position, and the instantaneous spatial position of the second node is repositionable within a frame of... Duke University

08/24/17 / #20170239160

Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives

A method for treating hair loss in mammals uses compositions containing 2-decarboxy-2-phosphinico prostaglandin derivatives. The compositions can be applied topically to the skin. The compositions can arrest hair loss, reverse hair loss, and promote hair growth. Compositions containing 2-decarboxy-2-phosphinico prostaglandin derivatives can also be used to lower intraocular pressure and... Duke University

08/24/17 / #20170239352

Combination drug therapy for the treatment of solid tumors

The present invention relates to a pharmaceutical combination that comprises an IGF1R inhibitor and an mTOR inhibitor for the treatment of cancer in a subject; a pharmaceutical composition comprising such a combination; the use of such a combination for the preparation of medicament for the treatment of cancer; a kit... Duke University

08/24/17 / #20170239363

Polymer conjugates having reduced antigenicity and methods of using the same

Disclosed herein are compositions and methods for reducing the antigenicity of molecules. The antigenicity of a molecule may be reduced or eliminated by conjugating at least one branched polymer to the molecule to form a molecule-polymer conjugate. The branched polymer may include a backbone and a plurality of side chains,... Duke University

08/17/17 / #20170233714

Polymer conjugates having reduced antigenicity and methods of using the same

Disclosed herein are compositions and methods for reducing the antigenicity of molecules, wherein the molecule comprises a uricase. The antigenicity of a molecule may be reduced or eliminated by conjugating at least one branched polymer to the molecule to form a molecule-polymer conjugate. The branched polymer may include a backbone... Duke University

08/10/17 / #20170224712

Prochelators as broad-spectrum antimicrobial agents and methods of use

The present disclosure provides methods of treating (including ameliorating and/or preventing) pathogenic infections by administering a therapeutically effective amount of a prochelator. The present disclosure further provides pharmaceutical compositions and a kit comprising the prochelator therein.... Duke University

08/10/17 / #20170227553

Compositions and methods for identifying and treating conditions involving hsf1 activity

Provided herein are methods for identifying and treating subjects having conditions involving reduced HSF1 activity (e.g., diminished HSF1 activity, diminished HSF1 protein levels, increased HSF1 Ser303 phosphorylation, increased HSF1 Ser307 phosphorylation) or conditions that benefit from increasing HSF1 abundance or activity beyond physiological levels.... Duke University

08/03/17 / #20170216289

Compositions and methods for the treatment of cancer

The present disclosure provides compositions and methods for the treatment of cancer, relating to the specific inhibition of Abelson (ABL) kinases.... Duke University

08/03/17 / #20170216382

Oncolytic poliovirus for human tumors

Human clinical use of a chimeric poliovirus construct has demonstrated excellent anti-tumor effect. The mechanism of action is believed to involve both viral oncolysis as well as immune recruitment, both of which lead to necrosis in the area of the tumor. No adverse effects have been observed.... Duke University

08/03/17 / #20170216426

Compositions and methods for transient immune response modulation during vaccination

In certain aspects the invention provides a selection of HIV-1 envelopes suitable for use as immunogens, and methods of using these immunogens to induce neutralizing antibodies. In certain embodiments, the immunogens are designed to trimerize. In other embodiments, the immunogenic compositions and methods comprise at least one agent for transient... Duke University

08/03/17 / #20170216808

Programmable liquid, gel and biohybrid compartments and methods of use

Nano- to microscale liquid coacervate particles are provided. The liquid coacervate particles are produced by a process including stimulating a population of liquid droplets containing one or a mixture of components to induce a phase separation point of a first component, and maintaining stimulation at the phase separation point to... Duke University

07/27/17 / #20170212195

Magnetic resonance imaging (mri) determining and adjusting inversion time (ti) using single-line acquisition and automatic compartment detection

Magnetic resonance imaging (MRI) systems and methods for determining and adjusting TI using single-line acquisition and automatic compartment detection. A method includes positioning a readout line of the MRI scanner through a compartment of interest of a region of interest in a subject. The method includes inverting magnetization within the... Duke University

07/20/17 / #20170202823

Method of treating cancer using selective estrogen receptor modulators

Disclosed herein are methods of treating subjects suffering from estrogen receptor positive cancer of the brain by administering a selective estrogen receptor degrader (SERM). Also disclosed are methods of treating a cancer that is resistant to an estrogen receptor modulator by administering a SERM.... Duke University

07/13/17 / #20170196892

Compositions and methods for the repair of myelin

Described are oxysterols, pharmaceutical compositions including the oxysterols, and methods of using the oxysterols and compositions for treating diseases and/or disorders related to myelin injury, such as neonatal brain injury, traumatic brain injury, spinal cord injury, cerebral palsy, seizures, cognitive delay, multiple sclerosis, stroke, autism, leukodystrophy, schizophrenia and bipolar disorder.... Duke University

07/13/17 / #20170196952

Vaccines against an oncogenic isoform of esr1 and methods of using the same

Methods of reducing the likelihood of a cancer or precancer developing resistance to a cancer therapeutic or prevention agent are provided herein. The methods include administering the cancer therapeutic or prevention agent and a vaccine comprising a polynucleotide encoding a polypeptide whose expression or activation is correlated with development of... Duke University

07/13/17 / #20170196953

Vaccines against an oncogenic isoform of her2 (erbb2) and methods of using the same

Methods of reducing the likelihood of a cancer or precancer developing resistance to a cancer therapeutic or prevention agent are provided herein. The methods include administering a vaccine comprising a polynucleotide encoding a polypeptide whose expression or activation is correlated with development of resistance of the cancer or precancer to... Duke University

07/13/17 / #20170196977

Methods and systems for treating cell proliferation disorders using plasmonics enhanced photospectral therapy (pepst) and exciton-plasmon enhanced phototherapy (epep)

The use of plasmonics enhanced photospectral therapy (PEPST) and exciton-plasmon enhanced phototherapy (EPEP) in the treatment of various cell proliferation disorders, the PEPST and EPEP agents and probes used therein, and pharmaceutical compositions using and/or containing the same.... Duke University

07/13/17 / #20170197206

Disposable pipette tip and methods of use

A kit for detection of an analyte of interest in a liquid sample, and methods of using, are provided. The kit may include a pipette and a disposable pipette tip configured to engage the pipette. The pipette tip may define an acoustic channel configured for allowing flow-through of a liquid.... Duke University








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