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Duquesne University Of The Holy Spirit patents


Recent patent applications related to Duquesne University Of The Holy Spirit. Duquesne University Of The Holy Spirit is listed as an Agent/Assignee. Note: Duquesne University Of The Holy Spirit may have other listings under different names/spellings. We're not affiliated with Duquesne University Of The Holy Spirit, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "D" | Duquesne University Of The Holy Spirit-related inventors


Conformationally restricted 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as anti-tumor agents

The present invention provides conformationally restricted 4-substituted 2,6-dimethylfuro[2,3-d]pyrimidine compounds and pharmaceutical compositions comprising these compounds. Preferably, the compounds exhibit dual inhibition of microtubule assembly and receptor tyrosine kinases. Methods of treating cancer comprising administering a therapeutically effective amount of at least one conformationally restricted 4-substituted 2,6-dimethylfuro[2,3-d]pyrimidine compound to a patient... Duquesne University Of The Holy Spirit

Substituted pyrimidine compounds and methods of use and manufacture

wherein X is absent, CH2, S, or O, and R is an alkyl group having from one to ten carbon atoms, and optionally salts, hydrates, or solvates thereof, that are useful in treating a patient having a disease or cancer. The compounds of this invention are useful as multi-enzyme antifolates... Duquesne University Of The Holy Spirit

Pyrimidine compounds and pyrimido indole compounds and methods of use

wherein R is hydrogen or an alkyl group having from one to ten carbon atoms, or a compound of the formula wherein the S is replaced by CH2, and optionally comprising a pharmaceutically acceptable salt, hydrate, or solvate thereof. A method of treating a patient having cancer or a disease... Duquesne University Of The Holy Spirit

Tricyclic compounds having antimitotic and/or antitumor activity and methods of use thereof

The present invention provides tricyclic compounds, pharmaceutically acceptable salts, solvates, or hydrates thereof, having antimitotic activity, anti-multidrug resistance activity, for example P-glycoprotein inhibition, and antitumor activity, and which inhibit paclitaxel sensitive and resistant tumor cells. Also provided are methods of utilizing these compounds for treating tumor cells and inhibiting mitosis... Duquesne University Of The Holy Spirit

Selective proton coupled folate transporter and folate receptor, and garftase inhibitor compounds and methods of using the same

These compounds are useful in methods for treating cancer, selectively targeting cancerous cells via the proton coupled folate transporter, folate receptor alpha, and/or folate receptor beta pathways, inhibiting GARFTase in cancerous cells, and selectively targeting activated macrophages in a patient having an autoimmune disease, such as rheumatoid arthritis.... Duquesne University Of The Holy Spirit

Monocyclic, thieno, pyrido, and pyrrolo pyrimidine compounds and methods of use and manufacture of the same

wherein R is H, a methyl group, an ethyl group, a n-propyl group, an iso-propyl group, or a n-butyl group; and R1 is H, a 4′-methyl group, a 4′-OH, a 4′-OMe group, a 2′,3′-C2H4 group, a; 3′,4′-C2H4 group, a 3′,4′-diF, a 3′,4′,5′-triF, or a 4′-OCF3; and optionally including a salt... Duquesne University Of The Holy Spirit

Tricyclic compounds having antimitotic and/or antitumor activity and methods of use thereof

The present invention provides tricyclic compounds, pharmaceutically acceptable salts, prodrugs, solvates, or hydrates thereof, having antimitotic activity, anti-multidrug resistance activity, for example P-glycoprotein inhibition, and antitumor activity, and which inhibit paclitaxel sensitive and resistant tumor cells. Also provided are methods of utilizing these compounds for treating tumor cells and inhibiting... Duquesne University Of The Holy Spirit








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