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Emory University patents


Recent patent applications related to Emory University. Emory University is listed as an Agent/Assignee. Note: Emory University may have other listings under different names/spellings. We're not affiliated with Emory University, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "E" | Emory University-related inventors


Treating or preventing nephrogenic diabetes insipidus

In certain embodiments, the disclosure relates to methods of treating or preventing nephrogenic diabetes insipidus comprising administering an effective amount of a AMPK activator to a subject in need thereof, wherein In certain embodiments, the AMPK activator is metformin or salt thereof. In certain embodiments, the subject has been diagnosed... Emory University

Progesterone phosphate analogs and uses related thereto

This disclosure relates to progesterone phophate derivatives and uses related thereto. In certain embodiments, the disclosure relates to compounds disclosed herein and uses for managing inflammation such as those resulting from traumatic brain injury or stroke.... Emory University

Biomarkers in cancer, methods, and systems related thereto

This disclosure relates biomarkers of cancer, e.g. prostate cancer. The biomarkers may be altered expression of nucleic acids, mutations, or proteins encoded therefrom. In certain embodiments, the disclosure relates to methods for diagnosing prostate cancer, methods of distinguishing between less aggressive and high aggressive prostate cancer, methods of determining predisposition... Emory University

Metal tricarbonyl complexes comprising substituted iminodiactic acid ligands and uses as radioisotope tracers

This disclosure relates to compositions comprising substituted iminodiacetic acid ligands and metal tricarbonyl complexes containing the ligands and derivatives thereof. In certain embodiments, the metal tricarbonyl complexes are used as radioisotope tracers such as renal tracers. In certain embodiments, the metal complexes comprise 99mTc or Re. In certain embodiments, the... Emory University

Particle-nucleic acid conjugates and therapeutic uses related thereto

This disclosure relates to particles conjugated to therapeutic nucleic acids. In certain embodiments, the nucleic acid comprises a sequence that catalytically cleaves RNA, e.g., DNAzyme or RNAzyme. In certain embodiments, the particles contain nucleic acids with both DNAzyme and/or RNAzyme and siRNA sequences. The cleaving nucleic acids optionally comprise a... Emory University

Biomarkers for malaria diagnosis

Disclosed herein are methods of detecting Plasmodium in a subject (for example, presence of Plasmodium parasite) by detecting the presence and/or amount of one or more metabolites in a sample from the subject. In some embodiments, the methods include detecting in the sample one or more metabolites listed in Table... Emory University

Glutamate dehydrogenase 1 inhibitors and methods of treating cancer

This disclosure relates to methods of treating or preventing cancer comprising administering an effective amount of a glutamate dehydrogenase 1 inhibitor to a subject in need thereof.... Emory University

Methods of improving behavioral therapies

This disclosure provides methods of using compounds that act to increase oxytocin release, including certain melanocortin receptor agonists, for treating or reducing the severity of psychotherapeutic or social disorders such as autism, and in particular the use of these compounds as an adjunct to psychotherapeutic counseling or behavioral therapy.... Emory University

Methods and devices for drug delivery to ocular tissue using microneedle

Methods and devices are provided for targeted administration of a drug to a patient's eye. In one embodiment, the method includes inserting a hollow microneedle into the sclera of the eye at an insertion site and infusing a fluid drug formulation through the inserted microneedle and into the suprachoroidal space... Emory University

Factor viii proteins having ancestral sequences, expression vectors, and uses related thereto

This disclosure relates to recombinant or chimeric FVIII proteins, variants, and vectors encoding the proteins containing one or more ancestral mutations. In certain embodiments, one or more protein domains comprise amino acid sequences that are derived from ancestrally reconstructed amino acid sequences. In certain embodiments, the disclosure relates to pharmaceutical... Emory University

Tak1 kinase inhibitors, compositions, and uses related thereto

The disclosure relates to TAK1 inhibitors, compositions, and uses related thereto. In certain embodiments, the disclosure relates to compounds of formula I, pharmaceutical compositions having a compound of formula I, and methods of treating or preventing cancer by administering an effective amount of a pharmaceutical composition having a compound of... Emory University

Cyanine-containing compounds for cancer imaging and treatment

This invention relates generally to cyanine-containing compounds; pharmaceutical compositions comprising cyanine-containing compounds; and methods of using cyanine-containing compounds for cancer cell imaging, cancer cell growth inhibition, and detecting cancer cells, for example. Compounds of the invention are preferentially taken up by cancer cells as compared to normal cells. This allows... Emory University

Diagnostic and therapeutic methods and products related to anxiety disorders

The present disclosure provides methods for diagnosing and treating anxiety disorders in female subjects. Diagnosis and treatment of such anxiety disorders are based, in part, on an analysis of pituitary adenylate cyclase-activating polypeptide (PACAP) expression levels in tissue collected from female subjects.... Emory University

Casein coated drug-loaded iron oxide nanoparticles

This disclosure relates to nanoparticle drug delivery systems composed of casein (CN) coated nanoparticles, e.g., iron oxide nanoparticles coated with an inner layer and an out layer comprising the milk protein casein. In certain embodiments, drug molecules are incorporated into an inner polymeric layer coating the nanoparticles, which are subsequently... Emory University

2',2'-dihalo nucleoside analogs for treatment of the flaviviridae family of viruses and cancer

The present invention is directed to compounds, compositions and methods for treating or preventing Flaviviridae family of viruses (including HCV, Yellow fever, Dengue, Chikungunya Ebola and West Nile virus), RSV, HEV, and influenza infection and cancer in human subjects or other animal hosts.... Emory University

Recombinant promoters and vectors for protein expression in liver and use thereof

Disclosed herein are recombinant viral vectors comprising a liver specific promotor in operable combination with a heterologous nucleic acid sequence encoding a protein, such as a clotting factor. Methods of treating a subject with a clotting disorder, such as hemophilia A or hemophilia B, are also provided.... Emory University

Magnetic resonance quantitative simultaneous multi-slice assessment of tissue displacement, deformation, and related biomarker parameters

Embodiments relate to a magnetic resonance imaging (MRI) technique in which the two-dimensional (2D) Displacement Encoding with Stimulated Echoes (DENSE) imaging technique and the multiband technique are combined to provide a 2D multi-slice quantitative assessment of displacement, deformation, and mechanics indices of tissue. The scan time is equivalent to the... Emory University

Antiviral jak inhibitors useful in treating or preventing retroviral and other viral infections

Compounds, compositions, and methods of treatment and prevention of HIV infection are disclosed. The compounds are pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidine JAK inhibitors. Combinations of these JAK inhibitors and additional antiretroviral compounds, such as NRTI, NNRTI, integrase inhibitors, entry inhibitors, protease inhibitors, and the like, are also disclosed. In one embodiment, the... Emory University

Thieno[2,3-d]pyrimidin-4-one derivatives as nmdar modulators and uses related thereto

The disclosure relates thieno[2,3-d]pyrimidin-4-one derivatives as modulators of NMDA receptors and uses related thereto. In certain embodiments, the disclosure relates to pharmaceutical compositions comprising compounds disclosed herein or pharmaceutically acceptable salts or prodrugs thereof. In certain embodiments, the compositions disclosed herein are used for managing conditions related to cognition, typically... Emory University

Soft tissue implant systems, kits, implants, devices and associated methods

The disclosure may relate to implant systems, kits, implants, devices, and associated methods that can quickly, easily and accurately deliver a soft tissue implant with minimal incisions/trauma to surrounding tissue. The soft implant may include one or more features disposed on or within the implant configured to engage an implant... Emory University

Compositions, uses, and preparation of platelet lysates

In certain embodiments, this disclosure describes compositions comprising platelet lysates depleted of fibrinogen. In a further embodiment, the composition further comprises a cell culture medium component. This disclosure also provides a method for preparing the composition, comprising the steps of (a) lysing platelets providing a lysate; (b) removing cell debris;... Emory University

7,8-dihydoxyflavone and 7,8-substituted flavone derivatives, compositions, and methods related thereto

BDNF and TrkB activity, such as psychiatric disorders, depression, post-traumatic stress disorder, and autism spectrum disorders, stroke, Rett syndrome, Parkinson's disease, and Alzheimer's disease by administering effective amounts of pharmaceutical compositions comprising compounds disclosed herein to a subject in need thereof. In certain embodiments, it is contemplated that the 7,8-substituted... Emory University

Methods of managing conditioned fear with neurokinin receptor antagonists

This disclosure relates to managing conditioned fear and conditions induced by experiencing or witnessing an extreme traumatic event using neurokinin receptor antagonists. In certain embodiments, the disclosure relates to methods of treating or preventing conditioned fear comprising administering an effective about neurokinin 3 receptor antagonist to a subject in need... Emory University

Vlps containing ligands and methods related thereto

This disclosure relates to immunogenic compositions and methods of enhancing an immune response to an antigen. In certain embodiments, the disclosure relates to virus-like carries comprising a TLR5 agonist on the exterior without an antigen.... Emory University

Methods and systems for determining sensory motor performance based on non-postural information

Methods and systems relate to determining sensory motor performance based on user non-postural movements within a generated dynamic virtual environment. The generated environment requires users to: (i) utilize primary sensor inputs (e.g., vision, vestibular sensation and somatosensation); (ii) assess the dynamic virtual environment; and (iii) integrate and translate those inputs... Emory University

Anti-fouling siloxane polymers and uses related thereto

This disclosure relates to polymer coatings with desirable anti-fouling properties. In certain embodiments, polymers are coated on particles which allow for conjugation with targeting moieties. In certain embodiments, the particles are nanoparticles with targeting moieties that bind with tumor associated antigens.... Emory University

Internet-based cognitive diagnostics using visual paired comparison task

Disclosed are methods for diagnosing declarative memory loss using mouse tracking to follow the visual gaze of a subject taking a visual paired comparison test. Also disclosed are methods for diagnosing dementia such as mild cognitive impairment and Alzheimer's disease.... Emory University

Apparatus and methods for drug delivery using microneedles

A microneedle has a proximal end portion and a distal end portion and defines a lumen. The proximal end portion is configured to be coupled to a cartridge to place the lumen in fluid communication with the cartridge. The proximal end portion includes a base surface that is configured to... Emory University

Saccharide analogs and agents for the diagnosis and therapy of bacterial infections

This disclosure relates saccharide analogs such as thiomaltose-based analogs for targeting bacteria and related uses. In certain embodiments, the disclosure relates to methods of transferring a molecule of interest into bacteria comprising mixing bacteria with a non-naturally occurring conjugate, wherein the conjugate comprises a thiomaltose-based analog and a molecule of... Emory University

Visually-based diagnostic device for automatic determination of a physiologic level associated with a sample

Diagnostic devices; systems, methods and computer-readable media store instructions related to determining hemoglobin information using those devices. The methods may include processing a captured image of the reservoir and/or device and the device information to determine color information for the solution and the scale, the color information including one or... Emory University

Methods for the treatment of cancer

The invention provides combinations comprising a MERTK inhibitor, or a pharmaceutically acceptable salt thereof, and an EGFR inhibitor and methods of use thereof, including methods of treating disorders such as cancer.... Emory University

Antagonism of the vip signaling pathway

Inhibition of the VIP signaling pathway with VIP antagonist is contemplated. In certain embodiments, the disclosure relates to methods of enhancing the immune response to a cell therapy comprising administering a VIP antagonist to a subject in combination with a cell. In certain embodiments, the subject is diagnosed with leukemia... Emory University

Devices and methods useful for detecting mechanical forces of ligand receptor interactions

This disclosure related to methods of detecting mechanical forces required to separate ligand and receptor interactions. In certain embodiments, this disclosure relates to methods of detecting mechanical forces between a ligand and receptor, where the ligand is immobilized on a surface using weaker forces. Ligand-receptor forces lead to dissociation of... Emory University

Compositions derived from platelet lysates and uses in vascularization

This disclosure relates to compositions comprising a fibrin polymer produced by mixing platelet lysates with a minimal essential medium and thrombin. Typically, an optimized concentration of a calcium salt is utilized. In certain embodiments, the disclosure contemplates compositions comprising a fibrin polymer made by processes disclosed herein that contains cells,... Emory University

Magnetic resonance quantitative time-resolved assessment of tissue displacement and related biomarker parameters with blood suppression in the whole cardiac cycle

Embodiments relate to acquiring magnetic resonance (MR) images with suppressed residual blood signal in the early cardiac phases, leading to images with a preferred dark-blood appearance throughout the entire cardiac cycle, which improves accuracy of subsequent post-processing algorithms. The acquisition of the desired blood suppressed tissue images is achieved through... Emory University

08/17/17 / #20170233428

Nucleoside analogs for treatment of the flaviviridae family of viruses and cancer

The present invention is directed to compounds, compositions and methods for treating or preventing Flaviviridae family of viruses (including HCV, Yellow fever, Dengue, Chikungunya and West Nile virus), RSV, HEV, and influenza infection and cancer in human subjects or other animal hosts.... Emory University

08/10/17 / #20170226173

Gm-csf and il-4 conjugates, compositions, and methods related thereto

In certain embodiments, this disclosure relates to conjugates comprising a polypeptide of GM-CSF and a polypeptide IL-4. Typically, the GM-CSF and IL-4 are connected by a linker, e.g., polypeptide. In certain embodiments, the disclosure relates to isolated nucleic acids encoding these polypeptide conjugates, vectors comprising nucleic acid encoding polypeptide conjugates,... Emory University

08/03/17 / #20170216319

Treating various disorders using trkb agonists

Novel compounds and methods for activating the TrkB receptor are provided. The methods include administering in vivo or in vitro a therapeutically effective amount of a compound containing four six-membered rings and a substituted or unsubstituted C5 or C6 heteroaryl or heterocycloalkyl ring and pharmaceutically acceptable salts, prodrugs, and derivatives... Emory University

08/03/17 / #20170216561

Delivery devices, delivering therapeutic materials

Delivery devices, systems, and methods may be configured to define a barrier region at a treatment site to deliver one or more therapeutic materials. A device for delivering one or more therapeutic materials to a treatment site may include a body; one or more members that are movable with respect... Emory University

07/27/17 / #20170209572

Classifiers of nf-kb pathway activation, devices, and methods of use thereof

This disclosure relates to classifiers of NF-κB pathway activation, devices, and methods of use thereof. In certain embodiments, the disclosure relates to methods comprising measuring changes in expression of genes controlled by p105 in a sample providing a detected p105 controlled gene expression pattern. In certain embodiments, the methods further... Emory University

07/13/17 / #20170196885

Use of gabaa receptor antagonists for the treatment of excessive sleepiness and disorders associated with excessive sleepiness

GABAA receptor mediated hypersomnia can be treated by administering a GABAA receptor antagonist (e.g., flumazenil; clarithromycin; picrotoxin; bicuculline; cicutoxin; and oenanthotoxin). In some embodiments, the GABAA receptor antagonist is flumazenil or clarithromycin. The GABAA receptor mediated hypersomnia includes shift work sleep disorder, obstructive sleep apnea/hypopnea syndrome, narcolepsy, excessive sleepiness, hypersomnia... Emory University

07/13/17 / #20170198303

Methods, devices and systems for enhanced transduction efficiency

The systems and methods are directed to leveraging the channel geometry and configuration to overcome diffusion limitations of current transduction systems. The methods may include a method of transducing target cells using a device. The device may include at least one continuous channel. The method may include delivering target cells... Emory University

06/22/17 / #20170173306

Spittable needle

Splittable needles for use in catheterizations are described. The splittable needles are formed of equal or unequal longitudinal parts that precisely align and lock for secure access to subject's vessels. The splittable needles are provided with a clamp, which has radially protruding handles and alignment and locking mechanisms. The splittable... Emory University

06/15/17 / #20170165225

Heterocyclic flavone derivatives, compositions, and methods related thereto

In certain embodiments, the disclosure relates to heterocyclic flavone derivatives, such as those described by formula provided herein, pharmaceutical compositions, and methods related thereto. In certain embodiments, the disclosure relates to methods of treating or preventing diseases or conditions related to BDNF and TrkB activity, such as depression, stroke, Rett... Emory University

06/15/17 / #20170166569

Asparagine endopeptidase (aep) inhibitors for managing cancer and compositions related thereto

This disclosure relates to asparagine endopeptidase inhibitors for managing cancer and compositions related thereto. In certain embodiments, the asparagine endopeptidase inhibitors are substituted 3,7-dihydropurine-2,6-dione derivatives useful for treating or preventing metastasis, tumor growth, and/or cancer. In certain embodiments, the disclosure relates to pharmaceutical compositions comprising an asparagine endopeptidase inhibitor and... Emory University

06/08/17 / #20170157178

Cellular compositions used to restore stem cell or progenitor cell function and methods related thereto

This disclosure relates to compounds, compositions and methods of epigenetically transforming cells. In certain embodiments, the disclosure relates to methods of generating epigenetically altered cells comprising mixing isolated cells with compositions disclosed herein under conditions such that epigenetically altered cells are formed. In certain embodiments, methods of treating or preventing... Emory University

06/08/17 / #20170160182
05/25/17 / #20170146520

Methods for the treatment of infections and tumors

PD-1 antagonists are disclosed that can be used to reduce the expression or activity of PD-1 in a subject. An immune response specific to an infectious agent or to tumor cells can be enhanced using these PD-1 antagonists in conjunction with an antigen from the infectious agent or tumor. Thus,... Emory University

05/18/17 / #20170137401

Chemokine cxcr4 and ccr5 receptor modulators and uses related thereto

The disclosure relates to chemokine receptor modulators and uses related thereto. In certain embodiments, the disclosure relates to pharmaceutical compositions comprising compounds disclosed herein or pharmaceutically acceptable salts or prodrugs thereof. In certain embodiments, the compositions disclosed herein are used for managing chemokine related conditions, typically prevention or treatment of... Emory University

05/18/17 / #20170137785

Polypeptide hydrogels and uses related thereto

This disclosure relates to self-assembling peptides that form hydrogels comprising peptide sequences for the activation of signaling pathways. In certain embodiments, the disclosure relates to compositions comprising a recombinant polypeptide comprising a cell signaling sequence, e.g., JAG-1 sequence, fused to a hydrogel polypeptide sequence. In certain embodiments, the disclosure relates... Emory University

05/04/17 / #20170119857

Method of administering porcine b-domainless fviii

The present invention provides a method of administering porcine B-domainless factor VIII (OBI-1) to a patient having factor VIII deficiency to provide more rapid and effective protection against bleeding episodes, compared to formerly available methods, or to provide more effective protection to such patients during non-bleeding periods. This invention is... Emory University

04/27/17 / #20170114400

Polynucleotide based movement, kits and methods related thereto

This disclosure relates DNA based movement of objects. In certain embodiments, particles, pairs of particles, or a rods are conjugated with single stranded DNA that hybridizes to a single stranded RNA that is conjugated to a substrate. When the DNA particle, pair of particles, or rod interacts with the surface... Emory University

04/27/17 / #20170118634

Methods and systems for determining protected location information based on temporal correlations

The systems and methods can provide location privacy protection by incorporating temporal correlations of a user's locations. The method may include obtaining a first location of a user of a mobile user device. The method may further include determining one or more probable locations of the user for a time... Emory University

04/20/17 / #20170106359

Water oxidation catalysts and methods of use thereof

Homogeneous water oxidation catalysts (WOCs) for the oxidation of water to produce hydrogen ions and oxygen, and methods of making and using thereof are described herein. In a preferred embodiment, the WOC is a polyoxometalate WOC which is hydrolytically stable, oxidatively stable, and thermally stable. The WOC oxidized waters in... Emory University

04/20/17 / #20170107489

Therapeutic use of cd31 expressing cells

The present invention features compositions and methods related to the isolation, culture and therapeutic use of CD31-expressing cells.... Emory University

04/13/17 / #20170100283

Tissue support structure

An apparatus includes a component having a shape memory material. The shape memory material has a first shape including a substantially elongate segment. The shape memory material has a second shape including a helix having a first ring and a second ring configured to exert a compressive force on a... Emory University

04/13/17 / #20170100477

Methods of immunizing a subject and compositions related thereto

This disclosure relates to methods of immunization comprising administering an effective amount of an immunogenic composition comprising an antigen or vaccine and an adjuvant disclosed herein to a subject in need thereof. In certain embodiments, the adjuvant is 1,8-dihydroxy-9,10-dihydroanthracen-9-one or derivative thereof. In certain embodiments, the adjuvant is N-(3,5-bis-trifluoromethyl-phenyl)-5-chloro-2-hydroxy-benzamide or... Emory University

03/23/17 / #20170079864

Surgical support devices and systems

These systems and devices can be placed on top of any commercially available standard operating table and therefore can provide a portable and inexpensive alternative to commercially available specialized operating tables. The system may include a frame body having a first end, a second end, and a length therebetween. The... Emory University

03/23/17 / #20170079950

Methods of managing graft versus host disease (gvhd) using indole carboxyaldehydes or derivatives thereof

In certain embodiments, this disclosure relates to methods of treating or preventing HvGD comprising administering an effective amount of indole-2-carboxyaldehyde, indole-3-carboxyaldehyde, or derivative to a subject in need thereof. In certain embodiments, this disclosure relates to methods of treating a subject with a hematological malignancy or other cancer comprising transplanting... Emory University

03/23/17 / #20170079971

Chemokine cxcr4 receptor modulators and uses related thereto

The disclosure relates to chemokine CXCR4 receptor modulators and uses related thereto. In certain embodiments, the disclosure relates to pharmaceutical compositions comprising compounds disclosed herein or pharmaceutically acceptable salts or prodrugs thereof. In certain embodiments, the compositions disclosed herein are used for managing CXCR4 related conditions, typically prevention or treatment... Emory University

03/23/17 / #20170081314

Prostaglandin receptor ep2 antagonists, derivatives, compositions, and uses related thereto

The disclosure relates to Prostaglandin receptor EP2 antagonists, derivatives, compositions, and methods related thereto. In certain embodiments, the disclosure relates to methods of treating or preventing conditions and diseases in which EP2 receptor activation has a physiological role, such as but not limited to, brain injury, inflammatory diseases, neuroinflammation after... Emory University

03/23/17 / #20170081385

Variable lymphocyte receptors (vlr) modifications and compositions and uses related thereto

This disclosure relates to variable lymphocyte receptors (VLRs) modifications such as humanized sequences and polypeptides comprising such sequences that specifically bind a target molecule and uses related thereto. In certain embodiments, the disclosure relates to recombinant polypeptide VLRs disclosed herein and variants thereof. In certain embodiments, this disclosure relates to... Emory University

03/23/17 / #20170082623

Methods of diagnosing and treating tuberculosis

This disclosure relates to methods of treating and diagnosing a tuberculosis infection as pulmonary active or latent based on biomarkers expressed on pools of CD4+ cells. In certain embodiments, the disclosure relates to methods of treatment of a subject diagnosed with tuberculosis comprising the steps of, measuring a pool of... Emory University

03/16/17 / #20170071896

Bh4 antagonists and methods related thereto

The disclosure relates to BH4 inhibitors and therapeutic uses relates thereto. In certain embodiments, the disclosure relates to methods of treating or preventing cancer, such as lung cancer, comprising administering therapeutically effective amount of a pharmaceutical composition comprising a compound disclosed herein or pharmaceutically acceptable salt to a subject in... Emory University

03/16/17 / #20170073387

Compositions of gm-csf and interleukin fusions for immune modulation and uses related thereto

This disclosure relates to recombinant proteins comprising a GM-CSF sequence and an interleukin sequence and nucleic acids related thereto. In certain embodiments, the disclosure relates to recombinant proteins comprises N-terminal sequences that are the result of improved production techniques and uses for treating or preventing autoimmune diseases such as multiple... Emory University

Patent Packs
03/16/17 / #20170076052

Methods and systems for dynamic management of a health condition

Methods and systems relate to dynamic management of a health condition based on the changing needs and status of individual patient(s) and/or provider(s). The method may include processing information to determine one or more health management factors for a patient; generating a health management plan for managing a health condition... Emory University

03/09/17 / #20170065615

Steroid analogues for neuroprotection

Provided are steroid analogues functionalized with polar substituents at the C3 and/or C20 positions of the steroid ring system that exhibit improved water solubility. Also provided are pharmaceutical compositions comprising the steroid analogues and methods using the novel steroid analogues for the treatment and prevention of neurodegeneration in a patient... Emory University

02/23/17 / #20170049468

Systems and methods for tissue treatment

Systems and methods are configured to treat a tissue by automatically linearly oscillating an instrument into a target site. A system may include a body having a length and configured to receive a portion of the instrument guide member having an exposed end and/or an instrument. The system may further... Emory University

02/23/17 / #20170049815

Selective chemotherapy treatments and diagnostic methods related thereto

This disclosure relates to methods of identifying subjects that have an increased likelihood of responding to a combination of a poly (ADP) ribose polymerase enzyme inhibitor and a platinum based reagent and optionally other anticancer agents in the course of chemotherapy. In certain embodiments, the disclosure relates to methods of... Emory University

02/23/17 / #20170049909

Compositions for the inactivation of virus replication and methods of making and using the same

Provided herein are recombinant constructs, vectors and expression cassettes including a first promoter which is suitably a tRNA promoter operably connected to a first polynucleotide encoding a first single guide RNA and a second promoter operably connected to a second polynucleotide encoding a Cas9 polypeptide. The first single guide RNA... Emory University

02/23/17 / #20170051284

Manipulating microrna for the management of neurological diseases or conditions and compositions related thereto

This disclosure relates to manipulating microRNA for the management of neurological disorders and compositions related thereto. In certain embodiments, the disclosure contemplates inhibition of miR324 or miR324-5p, e.g., the use of nucleobase polymers for antisense disruptions or RNA interference of miR-324 expression or for miR324-5p binding in order to increase... Emory University

02/16/17 / #20170042572

Systems for implanting and using a conduit within a tissue wall

Various embodiments of the present invention provide a conduit system including an outer lumen, an inner lumen, and an attaching device. In other embodiments, a multiple access port device adapted for communication with at least one of an outer lumen, an inner lumen, or an attaching device of a conduit... Emory University

02/16/17 / #20170042905

Prostaglandin receptor ep2 antagonists, derivatives, compositions, and uses related thereto

The disclosure relates to Prostaglandin receptor EP2 antagonists, derivatives, compositions, and methods related thereto. In certain embodiments, the disclosure relates to methods of treating or preventing conditions and diseases in which EP2 receptor activation has a physiological role, such as but not limited to, brain injury, inflammatory diseases, neuroinflamation after... Emory University

02/09/17 / #20170035771

Compounds and compositions for ossification and methods related thereto

The disclosure relates to compounds and compositions for forming bone and methods related thereto. In one embodiment, the disclosure relates to a composition comprising a compound disclosed herein, such as 2,4-diamino-1,3,5-triazine derivatives or salts thereof, for use in bone growth processes. In a typical embodiment, a bone graft composition is... Emory University

02/09/17 / #20170037078

2' -disubstituted nucleoside analogs for treatment of the flaviviridae family of viruses and cancer

The present invention is directed to compounds, compositions and methods for treating or preventing Flaviviridae family of viruses (including HCV, Yellow fever, Dengue, Chikungunya and West Nile virus), RSV and influenza infection and cancer in human subjects or other animal hosts. The compounds are as also pharmaceutically acceptable, salts, prodrugs,... Emory University

02/02/17 / #20170029407

Potent and selective inhibitors of hepatitis c virus

The present invention is directed to compounds, compositions and methods for treating or preventing hepatitis C virus (HCV) infection in human subjects or other animal hosts. The compounds are as also pharmaceutically acceptable, salts, prodrugs, and other derivatives thereof as pharmaceutical compositions and methods for treatment or prevention of HCV... Emory University

01/12/17 / #20170007652

Botanical extracts and compounds from schinus plants and methods of use

This disclosure relates to extracts from the Anacardiaceae (cashew plant family) and compositions comprising compounds contained therein. In certain embodiments, the extracts are derived from the fruit of a Schinus plant. In certain embodiments, the disclosure relates to methods of treating or preventing bacterial infections, acne, and other related uses.... Emory University

01/12/17 / #20170008947

Expression of chimeric polypeptide with variable lymphocyte receptors on immune cells and uses for treating cancer

This disclosure relates to recombinant cellular expression of chimeric proteins with peptide sequences derived from lymphocyte receptors and uses for treating cancer. In certain embodiments, the disclosure relates to a recombinant vector comprising a nucleic acid that encodes a chimeric protein with a segment with a targeting moiety based on... Emory University

01/05/17 / #20170000508

Devices and methods for stabilizing tissue

The devices and methods relate to devices for stabilizing and/or positioning tissue (e.g., heart) within a surgical area. The device may include an articulating arm and a tissue stabilizing member. The device may include one or more stabilizing segments disposed along at least a portion of the length of the... Emory University

01/05/17 / #20170000801

Triarylmethane analogs and their use in treating cancers

Compounds, pharmaceutical compositions including the compounds, and methods of preparation and use thereof are disclosed. The compounds are triphenyl methane analogs. The compounds and compositions can be used to treat and/or prevent a wide variety of cancers, including drug resistant cancers, inflammatory, degenerative and vascular diseases, including various ocular diseases,... Emory University

Patent Packs
01/05/17 / #20170000818

Nylon-3 polymers active against clostridium difficile

A method and corresponding composition to inhibit outgrowth of C. difficile spores and/or to inhibit growth of C. difficile vegetative cells in a mammal in which an amount of a nylon-3 polymer or nylon-3 copolymer or a pharmaceutically suitable salt thereof is administered to the subject.... Emory University

01/05/17 / #20170000841

Treatment of klebsiella pneumoniae with liposomally formulated glutathione

The composition of the invention, liposomal glutathione, has been recently shown to have utility for having an antibiotic like effect on Klebsiella pneumonia cultures in vitro, and in vivo as demonstrated by efficacy in reducing by large multiples the presence of cultures of Klebsiella in rats in animal tests. Further,... Emory University

01/05/17 / #20170002326

Purification of cell mixtures using molecular beacons targeting cell specific rna

This disclosure is in the area of research and therapeutics. In certain embodiments, it provides methods to assist in the purification of cell mixtures, e.g., cardiomyocytes, using molecular beacons targeting cell-type specific RNA, e.g. mRNA.... Emory University

08/10/17 / #20170224322

Sternal retractor

Devices and methods for sternal retraction that reduces bleeding from the cut edges of a sternum and reduces fracturing of the sternum during retraction. The devices and methods involve the use of sternal retractor blades having a certain geometry and inserts placed inside the sternal retractor blades during retraction of... Emory University








ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009



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