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Genesis Technologies Limited patents


Recent patent applications related to Genesis Technologies Limited. Genesis Technologies Limited is listed as an Agent/Assignee. Note: Genesis Technologies Limited may have other listings under different names/spellings. We're not affiliated with Genesis Technologies Limited, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "G" | Genesis Technologies Limited-related inventors


Selective caspase inhibitors and uses thereof

The present invention relates to compounds of formula i, ia, ii, iia, iii, or iiia and their pharmaceutical uses. Particular aspects of the invention relate to the use of those compounds for the selective inhibition of one or more caspases. ... Genesis Technologies Limited

Methods for reprogramming cells and uses thereof

A method of obtaining a cardiac multipotent or unipotent cell, comprising: i) providing a cell of a first type which is not a cardiac multipotent or unipotent cell; ii) introducing into the cell of a first type an agent capable of remodeling the chromatin and/or dna of the cell, wherein the agent capable of remodeling the chromatin and/or dna is a histone acetylator, an inhibitor of histone deacetylation, a dna demethylator, and/or a chemical inhibitor of dna methylation; iii) introducing into the cell of a first type a reprogramming polypeptide and/or a polynucleotide encoding said reprogramming polypeptide, wherein the reprogramming polypeptide comprises mesp1, brachyury (t), nkx2.5, and/or tbx5; and iv) placing or maintaining the cell in a cardiac cell culture medium and maintaining intracellular levels of the reprogramming polypeptide or the polynucleotide encoding the reprogramming polypeptide for a sufficient period of time to allow a cardiac multipotent or unipotent cell to be obtained.. . ... Genesis Technologies Limited

Methods for reprogramming cells and uses thereof

An in vitro human neural multipotent, unipotent, or somatic cell possessing all of the following characteristics: is derived from the reprogramming of a somatic cell, a progenitor cell or a stem cell that exhibits at least a transient increase in intracellular levels of at least one reprogramming agent; is not differentiated from a pluripotent cell; expresses one or more markers of a multipotent, unipotent or somatic cell not characteristic of a neural stem cell, neural precursor cell, neural progenitor cell, neuroblast, or neuron; is not a cancerous cell; is stable and not artificially maintained by forced gene expression and may be maintained in standard neural stem cell media or neural media; and does not exhibit uncontrolled growth, teratoma formation, and tumor formation in vivo; wherein the cell comprises at least one polypeptide or an expression vector encoding at least one polypeptide selected from the group consisting of: musashi1 (msi1); ngn2; msi1 and ngn2; msi1 and methyl-cpg binding domain protein 2 (mbd2); ngn2 and mbd2; msi1, ngn2 and mbd2; achaete-scute homolog 1 (ascl1); msi1, ngn2 and ascl1; msi1, ngn2, mbd2 and ascl1; sox2; msi1, ngn2 and sox2; and msi1, ngn2, mbd2 and sox2; wherein the expression vector is transiently expressed.. . ... Genesis Technologies Limited

Methods for reprogramming cells and uses thereof

A method of obtaining a neural multipotent, unipotent or somatic cell, comprising: i) providing a cell of a first type which is not a neural multipotent, unipotent or somatic cell; ii) introducing into the cell of a first type an agent capable of remodeling the chromatin and/or dna of the cell, wherein the agent capable of remodeling the chromatin and/or dna is a histone acetylator, an inhibitor of histone deacetylation, a dna demethylator, and/or a chemical inhibitor of dna methylation; iii) increasing directly or indirectly the endogenous expression of at least one neural multipotent or unipotent gene regulator in the cell of a first type, to a level at which the gene regulator is capable of driving transformation of the cell of a first type into the neural multipotent, unipotent or somatic cell, wherein the gene regulator is msi1, ngn2, sox2, ascl1, zic1 or a combination thereof; and iv) placing or maintaining the cell in a neural cell culture medium and maintaining intracellular levels of the reprogramming agent for a sufficient period of time to allow a neural multipotent, unipotent or somatic cell to be obtained.. . ... Genesis Technologies Limited

Methods for reprogramming cells and uses thereof

An in vitro human cardiac multi potent or unipotent cell that has the ability to proliferate; may be maintained in standard cardiac stem cell media; can differentiate to a progenitor, precursor, or somatic cell; has the characteristics of a cardiac stem cell, a cardiac precursor cell, or a cardiac progenitor cell; does not exhibit uncontrolled growth, teratoma formation, or tumor formation in vivo; expresses one or more markers of a multipotent, unipotent or somatic cell not characteristic of a cardiac stem cell, a cardiac precursor cell, or a cardiac progenitor cell; and is derived from the reprogramming of a somatic cell, a progenitor cell or a stem cell that exhibits at least a transient increase in intracellular levels of at least one reprogramming agent; wherein the cell comprises at least one transiently expressed polypeptide or an expression vector.. . ... Genesis Technologies Limited








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