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Gilead Sciences Inc patents


Recent patent applications related to Gilead Sciences Inc. Gilead Sciences Inc is listed as an Agent/Assignee. Note: Gilead Sciences Inc may have other listings under different names/spellings. We're not affiliated with Gilead Sciences Inc, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "G" | Gilead Sciences Inc-related inventors


 new patent  Combination methods for treating cancers

or a pharmaceutically acceptable salt thereof, in combination with a vinca-alkaloid, or a pharmaceutically acceptable salt thereof. The subject may be very high risk or high risk for the cancer and may not respond to either agent administered as a sole therapy. The subject who has the cancer may also... Gilead Sciences Inc

Cot modulators and methods of use thereof

The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.... Gilead Sciences Inc

Inhibitors of histone demethylases

Compounds of the form in which Q is selected from —COOH—CH═NR12, —W, —CH2NHR13, —CH=0 and —CH(OR17)2 capable of modulating the activity of histone demethylases (HDMEs), which are useful for prevention and/or treatment of diseases in which genomic dysregulation is involved in the pathogenesis, such as e.g. cancer and formulations and... Gilead Sciences Inc

Antiviral compounds

The disclosure is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.... Gilead Sciences Inc

Cot modulators and methods of use thereof

The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.... Gilead Sciences Inc

Pyrazolo[1,5-a]pyrimidines for antiviral treatment

or a pharmaceutically acceptable salt or ester, thereof, as described herein. The compounds and compositions thereof are useful for treating Pneumovirinae virus infections. The compounds, compositions, and methods provided are particularly useful for the treatment of Human respiratory syncytial virus infections.... Gilead Sciences Inc

Fxr (nr1h4) modulating compounds

The present disclosure relates generally to compounds which bind to the NR1H4 receptor (FXR) and act as agonists of FXR. The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by... Gilead Sciences Inc

Quinazoline compounds

Described herein are compounds of Formula (I) and tautomers and pharmaceutical salts thereof, compositions and formulations containing such compounds, and methods of using and making such compounds.... Gilead Sciences Inc

Fxr (nr1h4) modulating compounds

The present disclosure relates generally to compounds which bind to the NR1H4 receptor (FXR) and act as agonists of FXR. The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by... Gilead Sciences Inc

Fxr (nr1h4) modulating compounds

The present disclosure relates generally to compounds which bind to the NR1H4 receptor (FXR) and act as agonists of FXR. The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by... Gilead Sciences Inc

Compounds for the treatment of hepatitis b virus infection

The present disclosure generally relates to compounds and pharmaceutical compositions which may be used in methods of treating a hepatitis B virus infection.... Gilead Sciences Inc

Compounds and methods for antiviral treatment

Compounds and pharmaceutically acceptable salts and esters and compositions thereof, for treating viral infections are provided. The compounds and compositions are useful for treating Pneumovirinae virus infections. The compounds, compositions, and methods provided are particularly useful for the treatment of Human respiratory syncytial virus infections.... Gilead Sciences Inc

Crystalline forms of (2r,5s,13ar)-8-hydroxy-7,9-dioxo-n-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide

The present invention relates to crystalline forms and co-crystals of (2R,5S,13aR)-8-hydroxy-7,9-dioxo-N-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1′,2′:4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide, the pharmaceutical formulations, and the therapeutic uses thereof. The present invention also relates to novel crystalline forms of sodium (2R,5S,13aR)-7,9-dioxo-10-((2,4,6-trifluorobenzyl)carbamoyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1′,2′:4,5]pyrazino[2,1-b][1,3]oxazepin-8-olate Form I.... Gilead Sciences Inc

2'-chloro aminopyrimidinone and pyrimidine dione nucleosides

Provided herein are formulations, methods and substituted 2′-chloro aminopyrimidinone and pyrimidine dione compounds of Formula (I) for treating Pneumovirinae virus infections, including respiratory syncytial virus infections, as well as methods and intermediates for synthesis of substituted 2′-chloro aminopyrimidinone and pyrimidine dione compounds.... Gilead Sciences Inc

Therapeutic and diagnostic methods related to lysyl oxidase-like 2 (loxl2)

Provided are therapeutic, diagnostic, and prognostic methods for disease, including diseases associated with fibrosis and cancer using agents that bind to, inhibit, and/or detect lysyl oxidase-like 2 (LOXL2), and agents, compositions, kits, assay systems, and devices for use with such methods.... Gilead Sciences Inc

Solid forms of a toll-like receptor modulator

The present invention provides crystalline forms, solvates and hydrates of 4-amino-2-butoxy-8-(3-(pyrrolidin-1-ylmethyl)benzyl)-7,8-dihydropteridin-6(5H)-one, and methods of making.... Gilead Sciences Inc

Inhibitors of hepatitis c virus

or pharmaceutically acceptable salts thereof, wherein the various substituents are defined herein, methods of using said compounds, and pharmaceutical compositions containing said compounds.... Gilead Sciences Inc

Compositions and methods for treating cancer, inflammatory diseases and autoimmune diseases

The present disclosure provides compositions and methods of use comprising a matrix metalloproteinase-9 (MMP9) binding protein, alone or in combination with one or more additional therapeutic agents for the treatment or prevention of diseases and conditions.... Gilead Sciences Inc

Inhalable aztreonam for treatment and prevention of pulmonary bacterial infections

A method and a composition for treatment of pulmonary bacterial infections caused by gram-negative bacteria suitable for treatment of infection caused by Escherichia coli, Klebsiella pneumoniae, Klebsiella oxytoca, Pseudomonas aeruginosa, Haemophilus influenzae, Proteus mirabilis, Enterobacter species, Serratia marcescens as well as those caused by Burkholderia cepacia, Stenotrophomonas maltophilia, Alcaligenes xylosoxidans,... Gilead Sciences Inc

Novel fxr (nr1h4) modulating compounds

The present invention relates to compounds which bind to the NR1H4 receptor (FXR) and act as agonists of FXR. The invention further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said... Gilead Sciences Inc

Inhibitors of hepatitis c virus

As well as pharmaceutically acceptable salts thereof. Methods of using said compounds and pharmaceutical compositions containing said compounds are also disclosed.... Gilead Sciences Inc

Toll like receptor modulator compounds

The present disclosure relates generally to toll like receptor modulator compounds, such as diamino pyrido[3,2 D] pyrimidine compounds and pharmaceutical compositions which, among other things, modulate toll-like receptors (e.g. TLR-8), and methods of making and using them.... Gilead Sciences Inc

Methods of treating liver disease

The present disclosure relates to a method of preventing and/or treating liver disease comprising administering an ASK1 inhibitor in combination with a FXR agonist, to a patient in need thereof.... Gilead Sciences Inc

Compositions and methods for combination antiviral therapy

The present invention relates to therapeutic combinations of [2-(6-amino-purin-9 yl)-1-methyl-ethoxymethyl]-phosphonic acid diisopropoxycarbonyloxymethyl ester (tenofovir disoproxil fumarate, Viread®) and (2R, 5S, cis)-4-amino-5-fluoro-1-(2 hydroxymethyl-1,3-oxathiolan-5-yl)-(1H)-pyrimidin-2-one (emtricitabine, Emtriva™, (−)-cis FTC) and their physiologically functional derivatives. The combinations may be useful in the treatment of HIV infections, including infections with HIV mutants bearing resistance to... Gilead Sciences Inc

Crystalline forms of an antiviral compound

Also provided are processes of manufacture and methods of using the crystalline forms.... Gilead Sciences Inc

Lysyl oxidase-like 2 assay and methods of use thereof

The present disclosure provides an assay to detect and/or quantify circulating lysyl oxidase-like 2 (LOXL2) polypeptides in an individual. The assay is useful in diagnostic and prognostic applications, which are also provided.... Gilead Sciences Inc

Methods for treating cancers

or a pharmaceutically acceptable salt thereof. The subject may be very high risk or high risk for the cancer. The subject who has the cancer may also be refractory to at least one chemotherapy treatment, or is in relapse after treatment with chemotherapy, or both. The cancer may be a... Gilead Sciences Inc

Polycyclic-carbamoylpyridone compounds and their pharmaceutical use

including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, X, W, Y1, Y2, Z1, and Z4 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.... Gilead Sciences Inc

Compositions and methods for combination antiviral therapy

The present invention relates to therapeutic combinations of [2-(6-amino-purin-9 yl)-1-methyl-ethoxymethyl]-phosphonic acid diisopropoxycarbonyloxymethyl ester (tenofovir disoproxil fumarate, Viread®) and (2R, 5S, cis)-4-amino-5-fluoro-1-(2 hydroxymethyl-1,3-oxathiolan-5-yl)-(1H)-pyrimidin-2-one (emtricitabine, Emtriva™, (−)-cis FTC) and their physiologically functional derivatives. The combinations may be useful in the treatment of HIV infections, including infections with HIV mutants bearing resistance to... Gilead Sciences Inc

Processes for preparing ask1 inhibitors

which exhibits apoptosis signal-regulating kinase (“ASK1”) inhibitory activity and is thus useful in the treatment of diseases such as kidney disease, diabetic nephropathy and kidney fibrosis. The disclosure also provides compounds that are synthetic intermediates.... Gilead Sciences Inc

2' fluoro substituted carba-nucleoside analogs for antiviral treatment

wherein R2 is halogen. The compounds, compositions, and methods provided are particularly useful for the treatment of Human Influenza virus infections.... Gilead Sciences Inc

Apoptosis signal-regulating kinase inhibitor

The compound has apoptosis signal-regulating kinase (“ASK1”) inhibitory activity, and is thus useful in the treatment of diseases such as kidney disease, diabetic nephropathy and kidney fibrosis.... Gilead Sciences Inc

Crystalline form

The invention provides a crystalline form of the compound of formula (Ia), methods for making the crystalline form of the compound of formula (Ia), and therapeutic methods for the use of the crystalline form of the compound of formula (Ia).... Gilead Sciences Inc

Solid forms of an ask1 inhibitor

Also provided are processes of manufacture and methods of using the crystalline forms.... Gilead Sciences Inc

Synthesis of an antiviral compound

which is useful as an antiviral agent. The disclosure also provides compounds and processes for the preparation of the compounds that are synthetic intermediates to the compound of formula I.... Gilead Sciences Inc

07/27/17 / #20170210770

Phosphonate analogs of hiv inhibitor compounds

The invention is related to phosphorus substituted anti-viral inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.... Gilead Sciences Inc

07/13/17 / #20170196844

Apoptosis signal-regulating kinase inhibitors

wherein X1, X2, X3, X4, X5, X6, X7, X8, R1, R2, R3 are as defined above. The compounds have apoptosis signal-regulating kinase (“ASK1”) inhibitory activity, and are thus useful in the treatment of ASK1-mediated conditions, including autoimmune disorders, inflammatory diseases, cardiovascular diseases and neurodegenerative diseases. The invention also relates to... Gilead Sciences Inc

07/13/17 / #20170197985

Sodium (2r,5s,13ar)-7,9-dioxo-10-((2,4,6-trifluorobenzyl)carbamoyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepin-8-olate

The present Invention relates to sodium (2R,5S,13aR)-7,9-dioxo-10 ((2,4,6-trifluorobenzyl)carbamoyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1′,2′:4,5] pyrazino[2,1-b][1,3]oxazepin-8-olate Form I.... Gilead Sciences Inc

07/06/17 / #20170189337

Therapeutic compositions for treatment of human immunodeficiency virus

A solid oral dosage form is provided, comprising a compound of Formula I or a pharmaceutically acceptable salt thereof, tenofovir alafenamide or a pharmaceutically acceptable salt thereof, and emtricitabine or a pharmaceutically acceptable salt thereof.... Gilead Sciences Inc

07/06/17 / #20170190708

Pyrazolo[1,5-a]pyrimidines for antiviral treatment

or a pharmaceutically acceptable salt or ester, thereof, as described herein. The compounds and compositions thereof are useful for treating Pneumovirinae virus infections. The compounds, compositions, and methods provided are particularly useful for the treatment of Human respiratory syncytial virus infections.... Gilead Sciences Inc

07/06/17 / #20170190734

Macrocyclic inhibitors of flaviviridae viruses

and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of virus infections, particularly hepatitis C infections.... Gilead Sciences Inc

07/06/17 / #20170190737

Macrocyclic inhibitors of flaviviridae viruses

and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of virus infections, particularly hepatitis C infections.... Gilead Sciences Inc

07/06/17 / #20170190763

Human immunodeficiency virus neutralizing antibodies

The present invention provides novel anti-HIV antibodies with improved therapeutic properties, related pharmaceutical compositions, and methods of use thereof.... Gilead Sciences Inc

06/22/17 / #20170173031

Apoptosis signal-regulating kinase inhibitors

Wherein variables are as defined above. The compounds have apoptosis signal-regulating kinase (“ASK1”) inhibitory activity, and are thus useful in the treatment of ASK1-mediated conditions, including autoimmune disorders, inflammatory diseases, cardiovascular diseases, diabetes, diabetic nephropathy, cardio-renal diseases, including kidney disease, fibrotic diseases, respiratory diseases, COPD, idiopathic pulmonary fibrosis, acute lung... Gilead Sciences Inc

06/22/17 / #20170173034

Combination of a jak inhibitor and a syk inhibitor for treating cancers and inflammatory disorders

Provided herein are methods and pharmaceutical compositions for the treatment of inflammatory disorders comprising filgotinib and a Syk inhibitor.... Gilead Sciences Inc

06/22/17 / #20170174788

Combination of a jak inhibitor and an mmp9 binding protein for treating inflammatory disorders

Provided herein are methods and pharmaceutical compositions for the treatment of inflammatory disorders comprising filgotinib and a matrix metalloproteinase-9 (MMP9) binding protein.... Gilead Sciences Inc

06/08/17 / #20170158647

Modulators of pharmacokinetic properties of therapeutics

or a pharmaceutically acceptable salt, solvate, and/or ester thereof, compositions containing such compounds, therapeutic methods that include the administration of such compounds, and therapeutic methods and include the administration of such compounds with at least one additional therapeutic agent.... Gilead Sciences Inc

06/01/17 / #20170152240

Cot modulators and methods of use thereof

The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.... Gilead Sciences Inc

05/25/17 / #20170143680

Modulators of pharmacokinetic properties of therapeutics

or a pharmaceutically acceptable salt, solvate, and/or ester thereof, compositions containing such compounds, therapeutic methods that include the administration of such compounds, and therapeutic methods and include the administration of such compounds with at least one additional therapeutic agent.... Gilead Sciences Inc

05/25/17 / #20170143684

Novel fxr (nr1h4) binding and activity modulating compounds

The present invention relates to compounds which bind to the NR1H4 receptor (FXR) and act as agonists of FXR. The invention further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said... Gilead Sciences Inc

05/18/17 / #20170136000

Method of treating a viral infection using elvitegravir combinations

The invention includes methods, compositions, and kits useful for treating a viral infection by coadministering 6-(3-chloro-2-fluorobenzyl)-1-[(2S)-1-hydroxy-3-methylbutan-2-yl]-7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid or a pharmaceutically acceptable salt thereof, with lopinavir or a pharmaceutically acceptable salt thereof.... Gilead Sciences Inc

05/18/17 / #20170136001

Method of treating a viral infection using elvitegravir combinations

The invention includes methods, compositions, and kits useful for treating a viral infection by administering 6-(3-chloro-2-fluorobenzyl)-1-[(2S)-1-hydroxy-3-methylbutan-2-yl]-7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid or a pharmaceutically acceptable salt thereof, with atazanavir or a pharmaceutically acceptable salt thereof, and optionally with a compound that inhibits cytochrome P-450, or a pharmaceutically acceptable salt thereof.... Gilead Sciences Inc

05/18/17 / #20170136016

Method for treating a pulmonary hypertension condition

A method for treating a pulmonary hypertension condition such as pulmonary arterial hypertension (PAH) in a subject comprises administering to the subject a therapeutically effective amount of ambrisentan, wherein, at baseline, time from first diagnosis of the condition in the subject is not greater than about 2 years... Gilead Sciences Inc

05/18/17 / #20170137405

Compounds for the treatment of hiv

The invention provides compounds of formula (I): or a salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of formula (I), processes for preparing compounds of formula (I), intermediates useful for preparing compounds of formula I and therapeutic methods for treating a Retroviridae viral infection... Gilead Sciences Inc

05/11/17 / #20170128443

Polycyclic-carbamoylpyridone compounds and their pharmaceutical use

including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, X, Y1, Y2, or L are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.... Gilead Sciences Inc

05/11/17 / #20170128444

Polycyclic-carbamoylpyridone compounds and their pharmaceutical use

including stereoisomers and pharmaceutically acceptable salts thereof, wherein L, R5, W, X, Y1, Y2, and Z are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.... Gilead Sciences Inc

05/04/17 / #20170119764

Polycycliccarbamoylpyridone compounds and their pharmaceutical use

including stereoisomers and pharmaceutically acceptable salts thereof, wherein A′, R1, R2 and R3 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.... Gilead Sciences Inc

04/27/17 / #20170114048

Compounds and combinations for the treatment of hiv

Provided are compounds, compositions, combinations, kits, uses, and methods for treating HIV in a human being using such compounds or combinations with proteasome inhibitors.... Gilead Sciences Inc

04/27/17 / #20170114074

Polycyclic-carbamoylpyridone compounds and their pharmaceutical use

including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, X, W, Y1, Y2, Z1, Z2, or Z4 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.... Gilead Sciences Inc

04/27/17 / #20170114086

2'- substituted carba-nucleoside analogs for antiviral treatment

as well as pharmaceutical compositions containing compounds of Formula I and methods for treating Orthomyxoviridae virus infections by administering these compounds. The compounds, compositions, and methods provided are particularly useful for the treatment of Human Influenza virus infections.... Gilead Sciences Inc

03/30/17 / #20170088527

Fused heterocyclic compounds as ion channel modulators

wherein X, Y, Z, R2, R3, R4, p and q are as described herein, to methods for the preparation and use of the compounds and to pharmaceutical compositions containing the same.... Gilead Sciences Inc

03/30/17 / #20170088554

Therapeutic compounds

or a salt thereof as described herein. The invention also provided pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the... Gilead Sciences Inc

03/30/17 / #20170088576

Antiviral compounds

The invention is related to phosphorus substituted anti-viral inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.... Gilead Sciences Inc

03/16/17 / #20170071944

Modulators of toll-like receptors for the treatment of hiv

Provided are methods, uses, pharmaceutical regimens, pharmaceutical compositions, and kits comprising modulators of TLR8 and pharmaceutically acceptable salts thereof, useful in treating HIV infections.... Gilead Sciences Inc

03/16/17 / #20170071964

Methods for treating arenaviridae and coronaviridae virus infections

wherein the 1′ position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are particularly useful for the treatment of Lassa virus and Junin virus infections.... Gilead Sciences Inc

Patent Packs
03/02/17 / #20170056423

Combination therapy comprising tenofovir alafenamide hemifumarate and cobicistat for use in the treatment of viral infections

The use of the hemifumarate form of {9-[(R)-2-[[(S)-[[(S)-1-(isopropoxycarbonyl)ethyl]amino]phenoxyphosphinyl]methoxy]propyl]adenine} (tenofovir alafenamide hemifumarate) in combination with cobicistat is disclosed. In addition, the combination of tenofovir alafenamide hemifumarate, cobicistat, emtricitabine, and elvitegravir, and the combination of tenofovir alafenamide hemifumarate, cobicistat, emtricitabine, and darunavir, are disclosed.... Gilead Sciences Inc

03/02/17 / #20170056424

Solid forms of tenofovir

The present invention relates to solid forms of tenofovir and methods for preparation, use and isolation of such forms.... Gilead Sciences Inc

03/02/17 / #20170057976

Polycyclic-carbamoylpyridone compounds and their pharmaceutical use

including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, X, W, Y1, Y2, Z1, and Z4 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.... Gilead Sciences Inc

02/16/17 / #20170042961

Methods for treating hcv

This invention relates to combinations of therapeutic molecules useful for treating hepatitis C virus infection. The present invention relates to methods, uses, dosing regimens, and compositions.... Gilead Sciences Inc

02/09/17 / #20170035755

Syk inhibitors

wherein R1, R2, R3, and R4 are as described herein. The present disclosure further provides pharmaceutical compositions that include a compound of Formula I, or pharmaceutically acceptable salts thereof, and methods of using these compounds and compositions to treat conditions mediated by Syk. In certain embodiments, also disclosed are methods... Gilead Sciences Inc

02/02/17 / #20170027967

Pharmaceutical formulations

The invention provides a solid oral dosage form comprising rilpivirine or a pharmaceutically acceptable salt thereof, tenofovir alafenamide or a pharmaceutically acceptable salt thereof, and emtricitabine or a pharmaceutically acceptable salt thereof.... Gilead Sciences Inc

02/02/17 / #20170029427

Compounds and methods for antiviral treatment

Compounds and pharmaceutically acceptable salts and esters and compositions thereof, for treating viral infections are provided. The compounds and compositions are useful for treating Pneumovirinae virus infections. The compounds, compositions, and methods provided are particularly useful for the treatment of Human respiratory syncytial virus infections.... Gilead Sciences Inc

01/19/17 / #20170014389

Inhalable aztreonam lysinate formulation for treatment and prevention of pulmonary bacterial infections

A method and a composition for treatment of pulmonary bacterial infections caused by gram-negative bacteria suitable for treatment of infection caused by Escherichia coli, Klebsiella pneumoniae, Klebsiella oxytoca, Pseudomonas aeruginosa, Haemophilus influenzae, Proteus mirabilis, Enterobacter species, Serratia marcescens as well as those caused by Burkholderia cepacia, Stenotrophomonas maltophilia, Alcaligenes xylosoxidans,... Gilead Sciences Inc

01/12/17 / #20170008873

Cot modulators and methods of use thereof

The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.... Gilead Sciences Inc

01/12/17 / #20170008897

Pyrrolo[1,2-f][1,2,4]triazines useful for treating respiratory syncitial virus infections

Provided herein are formulations, methods and substituted tetrahydrofuranyl-pyrrolo[1,2-f][1,2,4]triazine-4-amine compounds of Formula (I) for treating Pneumovirinae virus infections, including respiratory syncytial virus infections, as well as methods and intermediates for synthesis of tetrahydrofuranyl-pyrrolo[1,2-f][1,2,4]triazine-4-amine compounds.... Gilead Sciences Inc

01/12/17 / #20170008905

Cot modulators and methods of use thereof

The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.... Gilead Sciences Inc

01/05/17 / #20170000807

Pharmaceutical formulations

The invention provides a solid oral dosage form comprising tenofovir alafenamide or a pharmaceutically acceptable salt thereof, and emtricitabine or a pharmaceutically acceptable salt thereof.... Gilead Sciences Inc








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