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Icahn School Of Medicine At Mount Sinai
Icahn School Of Medicine At Mount Sinai School

Icahn School Of Medicine At Mount Sinai patents


Recent patent applications related to Icahn School Of Medicine At Mount Sinai. Icahn School Of Medicine At Mount Sinai is listed as an Agent/Assignee. Note: Icahn School Of Medicine At Mount Sinai may have other listings under different names/spellings. We're not affiliated with Icahn School Of Medicine At Mount Sinai, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "I" | Icahn School Of Medicine At Mount Sinai-related inventors


Benzenesulfonamide upregulators of npc1 for neimann-pick disease and other lysosomal storage disorders

Methods and compositions for treating lysosomal storage disorders are disclosed. The methods involve administering a genus of benzenesulfonamides, particularly N-[3-(aminosulfonyl)phenyl]-benzamides and heteroarylamides. A genus of suitable compounds is shown in formula 1:... Icahn School Of Medicine At Mount Sinai

Rna containing compositions and methods of their use

The present invention relates to a composition comprising an isolated, single stranded RNA molecule having a nucleotide sequence comprising 20 or more bases and a pattern of CpG dinucleotides defined by a strength of statistical bias greater than or equal to zero, and a pharmaceutically acceptable carrier suitable for injection.... Icahn School Of Medicine At Mount Sinai

Compositions and methods for inhibiting expression of the alas1 gene

The invention relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the ALAS1 gene, and methods of using such dsRNA compositions to alter (e.g., inhibit) expression of ALAS1.... Icahn School Of Medicine At Mount Sinai

Methods for preventing or treating infectious diseases caused by extracellular microorganisms, including antimicrobial-resistant strains thereof, using gallium compounds

The present invention relates to methods for preventing or treating infectious diseases caused by extracellular microorganisms, such as bacteria and fungi, by systemically administering to a patient a compound containing gallium. The extracellular microorganisms targeted by the present methods include methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus faecalis (VRE), E. coli... Icahn School Of Medicine At Mount Sinai

Method of maintaining the anti-depressant effect of ketamine with lithium

Disclosed herein is method for maintaining the anti-depressant effect of ketamine by administering lithium to patients that respond to ketamine treatment.... Icahn School Of Medicine At Mount Sinai

Influenza virus vaccination regimens

Provided herein are immunization regimens for inducing an immune response (e.g., an antibody response) against influenza virus. In specific aspects, the immunization regimens involve the administration of a chimeric hemagglutinin (HA), a headless HA or another influenza virus stem domain based construct (e.g., the HA stem domain or a fragment... Icahn School Of Medicine At Mount Sinai

Tricyclic heterocycles as anticancer agents

in which Het is an aromatic heterocyclic ring and Y is a point of attachment of various side chains and rings. An example of such a compound is 4-chloro-N-(3-(10,11-dihydro-5H-benzo[b]pyrido[2,3-f]azepin-5-yl)propyl)benzenesulfonamide:... Icahn School Of Medicine At Mount Sinai

Influenza virus vaccines and uses thereof

Provided herein are influenza hemagglutinin stem domain polypeptides, compositions comprising the same, vaccines comprising the same and methods of their use.... Icahn School Of Medicine At Mount Sinai

Method of forming a lipid bilayer

The present application is directed, at least in part, to a process for forming droplet interface blayers (DIBs). In one or more embodiments, a housing is produced wherein the housing includes at least one aperture that comprises a cis portion and a trans portion, at least one cis electrode receptacle... Icahn School Of Medicine At Mount Sinai

Methods for determining recombination diversity at a genomic locus

The present disclosure relates to methods for determining recombination diversity at a genomic locus of interest. The method includes fragmenting nucleic acids isolated from immune cells, ligating adaptors to the fragmented or amplified nucleic acids, and selectively amplifying nucleic acids containing a recombined junction at the genomic locus of interest.... Icahn School Of Medicine At Mount Sinai

Mass production and size control of nanoparticles through controlled microvortices

Methods for making particles, such as nanoparticles, devices useful in the methods, and particles made by the method are described herein. The methods involves the use of microfluidic device, such that upon mixing solutions of the materials to form the particles (or a solution of the material or materials to... Icahn School Of Medicine At Mount Sinai

Recombinant rna viruses and uses thereof

Described herein are modified RNA virus gene segments and nucleic acids encoding modified RNA virus gene segments. Also described herein are recombinant RNA viruses comprising modified RNA virus gene segments and the use of such recombinant RNA viruses for the prevention and treatment of disease.... Icahn School Of Medicine At Mount Sinai

Systems and methods for treating a psychiatric disorder

Systems and methods for treating a subject with a psychiatric disorder are provided in which a therapy session is conducted. In the therapy session, each respective expression image in a plurality of expression images is sequentially displayed. Each expression image is independently associated with an expression. The successive display of... Icahn School Of Medicine At Mount Sinai

Stem cell gene targeting

The invention provides a method for generating a transgenic eukaryotic cell population having a modified human Rosa26 locus, which method includes introducing a functional DNA sequence into the human Rosa26 locus of starting eukaryotic cells. Also provided are targeting vectors useful in the method, as well as a cell population... Icahn School Of Medicine At Mount Sinai

Automated, multifunctional, engineered cardiac tissue culture and testing bioreactor system

An improved tissue engineering bioreactor and testing platform has been designed that integrates multiple testing and stimulation capabilities. The system allows for growth of multiple tissue strips in parallel with mechanical and electrical stimulation, media perfusion, and the automated monitoring of contractile force and extracellular electrical activity. The system is... Icahn School Of Medicine At Mount Sinai

Methods for producing a slice-selective adiabatic t2 preparation pulse and devices thereof

A method, magnetic resonance imaging computing device, and a non-transitory computer readable medium for producing a slice-selective adiabatic magnetization T2 preparation pulse for magnetic resonance imaging. A pulse control signal including an adiabatic half passage pulse control signal, an adiabatic full passage pulse control signal, and a reverse adiabatic half... Icahn School Of Medicine At Mount Sinai

Electronic phenotyping technique for diagnosing chronic kidney disease

An example method of diagnosing chronic kidney disease (CKD) includes obtaining an electronic medical record for a patient having medical data. The medical data includes an indication if the patient had been previously diagnosed with CKD, an indication if the patient had previously undergone a kidney transplant, an indication if... Icahn School Of Medicine At Mount Sinai

Automatic disease diagnoses using longitudinal medical record data

An example method of automated medical diagnosis includes obtaining an electronic longitudinal data set for each of a plurality of patients, where each data set includes a plurality of measurement values corresponding to a metric, where each measurement value is associated with a respective time point. The method also includes... Icahn School Of Medicine At Mount Sinai

Targeted protein replacement for the treatment of lysosomal storage disorders

The present invention relates to compositions and methods for delivering lysosomal proteins. The compositions and methods described herein permit the targeted delivery of exogenous lysosomal proteins to cell surface proteins that allow their internalization via non-clathrin pathways. The present invention further relates to the use of the compositions and methods... Icahn School Of Medicine At Mount Sinai

Peptides, reagents and methods for detecting food allergy

Provided are peptide biomarkers for diagnosis of allergy, monitoring development of clinical tolerance in an allergic individual, and predicting whether an allergic subject is likely to develop clinical or natural tolerance over time. The invention also relates to diagnostic methods and diagnostic kits employing the peptide biomarkers.... Icahn School Of Medicine At Mount Sinai

Systems and methods for causal inference in network structures using belief propagation

Systems and method for perturbing a system include obtaining directed acyclic/cyclic graph candidates {GI, . . . , GN} for the system. Each Gi in {Gj, . . . GN} includes a causal relationship between a parent and child node. {GI, GN} demonstrate Markov equivalence. Observed data D is obtained... Icahn School Of Medicine At Mount Sinai

Ceacam5 peptides for crohn's disease

The present invention relates to small peptides, derived from the N-terminal domain of CEACAM5 (carcinoembryonic antigen family member 5), with the ability to stimulate the suppressive activity of CD8+ T cells in Crohn's disease. Pharmaceutical formulations, methods to treat patients with Crohn's disease, and methods to identify candidate peptides for... Icahn School Of Medicine At Mount Sinai

Intranasal administration of ketamine to treat depression

Methods and compositions for the treatment of treatment-resistant depression are described. More specifically, the invention demonstrates that intranasal administration of ketamine is effective to ameliorate the symptoms of depression in a patient who has not responded to an adequate trial of one antidepressant in the current episode and has recurrent... Icahn School Of Medicine At Mount Sinai

Methods and compositions for treatment of lipid storage disorders

Treating subjects having a lipid storage disorder with a composition comprising a PKC activator, such as bryostatins, bryologs, and polyunsaturated fatty acids. Accordingly, the present disclosure provides methods for treating human subjects suffering from lipid storage disorders, such as Niemann-Pick disease, by administering PKC activators. The present disclosure provides, according... Icahn School Of Medicine At Mount Sinai

Methods for producing a semi-adiabatic spectral-spatial spectroscopic imaging sequence and devices thereof

A method, magnetic resonance imaging computing device, and a non-transitory computer readable medium for producing a semi-adiabatic spectral-spatial spectroscopic imaging sequence for magnetic resonance imaging. A pulse control signal comprising a pair of adiabatic pulses and a linear phase pulse is generated. The pulse control signal is transformed into a... Icahn School Of Medicine At Mount Sinai

Intranasal administration of ketamine to treat depression

Methods and compositions for the treatment of treatment-resistant depression are described. More specifically, the invention demonstrates that intranasal administration of ketamine is effective to ameliorate the symptoms of depression in a patient who has not responded to an adequate trial of one antidepressant in the current episode and has recurrent... Icahn School Of Medicine At Mount Sinai

Genetically engineered swine influenza virus and uses thereof

The present invention relates, in general, to attenuated swine influenza viruses having an impaired ability to antagonize the cellular interferon (IFN) response, and the use of such attenuated viruses in vaccine and pharmaceutical formulations. In particular, the invention relates to attenuated swine influenza viruses having modifications to a swine NS1... Icahn School Of Medicine At Mount Sinai

Methods for diagnosing risk of renal allograft fibrosis and rejection

Disclosed herein is a method for diagnosing a renal allograft recipient's risk for developing fibrosis of the allograft and allograft loss. The method includes determining the expression levels of certain microRNAs, which have been determined to be predictive of an allograft recipient's risk. Also disclosed herein is a method of... Icahn School Of Medicine At Mount Sinai

Method for diagnosing subclinical and clinical acute rejection by analysis of predictive gene sets

Disclosed herein are methods for diagnosing acute cellular rejection (ACR) of an allograft by analysis of predictive gene sets and kits for practicing these methods.... Icahn School Of Medicine At Mount Sinai

Method for identifying kidney allograft recipients at risk for chronic injury

A method for identifying a renal allograft recipient at risk for chronic allograft damage or interstutial fibrosis and tubular atrophy (IF/TA) by comparing the transcription level of a preselected gene signature set with the transcription level of a comparison standard, and diagnosing the recipient as being at risk for chronic... Icahn School Of Medicine At Mount Sinai

Small molecule transcription modulators of bromodomains

This disclosure relates generally to compounds and compositions comprising one or more indole analogs. These compounds are useful for treating diseases associated with NF-kB and p53 activity, such as cancer and inflammatory diseases.... Icahn School Of Medicine At Mount Sinai

Method and apparatus to prepare cardiac organoids in a bioreactor system

A bioreactor system for preparing a cardiac organoid chamber and for subsequent testing thereof is described herein and shown in the exemplary drawing figures. The bioreactor system includes a first vessel having a hollow interior and an open top. A first cover is mated with the open top of the... Icahn School Of Medicine At Mount Sinai

Serca2 therapeutic compositions and methods of use

The present invention provides methods for treating pulmonary hypertension in a subject by delivering a therapeutic adeno-associated virus (AAV)-SERCA2 composition to a subject in need thereof.... Icahn School Of Medicine At Mount Sinai

Detection methods employing hcv core lipid and dna binding domain monoclonal antibodies

The present disclosure provides detection methods employing HCV core lipid binding domain and DNA binding domain monoclonal antibodies or antibody fragments. In certain embodiments, the lipid binding domain monoclonal antibody or antibody fragment recognizes an epitope in amino acids 141 to 161 of HCV core protein and the DNA binding... Icahn School Of Medicine At Mount Sinai

02/16/17 / #20170042840

Use of 1,3-propanedisulfonic acid or pharmaceutically acceptable salts thereof for the treatment of sarcoidosis

The present disclosure relates to methods for the treatment of sarcoidosis. In certain aspects and embodiments, the disclosure provides compositions containing 1,3-propanedisulfonic acid or a pharmaceutically acceptable salt thereof and/or the use of such compositions for the treatment of Sarcoidosis. In another aspect, the disclosure relates to compositions containing 1,3-propanedisulfonic... Icahn School Of Medicine At Mount Sinai

02/09/17 / #20170037379

Chimeric viruses presenting non-native surface proteins and uses thereof

The present invention provides chimeric negative-stand RNA viruses that allow a subject, e.g., an avian, to be immunized against two infectious agents by using a single chimeric virus of the invention. In particular, the present invention provides chimeric influenza viruses engineered to express and incorporate into their virions a fusion... Icahn School Of Medicine At Mount Sinai

01/26/17 / #20170020998

Ceramide levels in the treatment and prevention of infections

The present invention relates to a method for treating or preventing pathogenic infections in a subject having Cystic Fibrosis, COPD, and/or an open wound. This method involves selecting a subject having Cystic Fibrosis, COPD, and/or an open wound and administering to the selected subject a ceramidase under conditions effective to... Icahn School Of Medicine At Mount Sinai

01/19/17 / #20170014494

Sumoylation of serca2a and cardiovascular disease

Methods for treating cardiovascular disease, and in particular heart failure, are provided comprising administering a therapeutically effective amount of a modulator of SERCA2a post-translation modification such as SUMOylation or acetylation. Also provided are methods of treating cardiovascular disease by inhibiting SERCA2a degradation. Further provided are methods of diagnosing a propensity... Icahn School Of Medicine At Mount Sinai

01/19/17 / #20170015625

Sulfonamides derived from tricyclyl-2-aminocycloalkanols as anticancer agents

The compounds induce FOXO1 transcription factor translocation to the nucleus by modulating PP2A and, as a consequence, exhibit anti-proliferative effects. They are useful in the treatment of a variety of disorders, including as a monotherapy in cancer treatment, or used in combination with other drugs to restore sensitivity to chemotherapy... Icahn School Of Medicine At Mount Sinai

01/19/17 / #20170015630

Constrained tricyclic sulfonamides

Tricyclic chemical modulators of protein phosphatase 2A are disclosed. The compounds are useful to treat cancer, age-onset proteotoxicity, stress-induced depression, inflammation, and acne. The compounds are of the following phenothiazine and dibenzoazepine compounds and similar genera:... Icahn School Of Medicine At Mount Sinai








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