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Indiana University Research And Technology Corporation
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Indiana University Research And Technology Corp patents


Recent patent applications related to Indiana University Research And Technology Corp. Indiana University Research And Technology Corp is listed as an Agent/Assignee. Note: Indiana University Research And Technology Corp may have other listings under different names/spellings. We're not affiliated with Indiana University Research And Technology Corp, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "I" | Indiana University Research And Technology Corp-related inventors


Rechargeable alkaline metal and alkaline earth electrodes having controlled dendritic growth and methods for making and using same

A device for extending the life of a battery, including an electrode having a metal portion, wherein the metal portion is selected from the group including lithium, calcium, magnesium, sodium, potassium and combinations thereof, an electrolyte permeable membrane, and a metal dendrite seeding material disposed between the electrode and the... Indiana University Research And Technology Corp

Hepatitis b viral assembly effectors

Novel assembly effector compounds having a therapeutic effect against hepatitis B viral (HBV) infection are disclosed. Assembly effector molecules described herein can lead to defective viral assembly and also may affect other viral activities associated with chronic HBV infection. Also disclosed is a process to synthesize disclosed compounds, method of... Indiana University Research And Technology Corp

Targeting cgmp-related phosphodiesterases to reduce cyst formation in cystic kidney disease, and related materials and methods

Described herein is the identification of cGMP-specific phosphodiesterase upregulation in cystic kidney diseases. Also described is the use of cGMP-specific phosphodiesterase inhibitors for preventing the progression and/or treatment of cystic kidney diseases. Other aspects described provide medicaments for preventing the progression and/or treating cystic kidney diseases, and methods of diagnosing... Indiana University Research And Technology Corp

Flow assembly for cells

In one embodiment, a flow assembly for cells comprises a first flow path configured to receive a plurality of cells, a second flow path configured to receive a buffer, and a third flow path configured to receive the plurality of cells and the buffer. The plurality of cells are in... Indiana University Research And Technology Corp

Methods of treating autoimmune and/or glomerulonephritis-associated diseases using shp2 inhibitors

Methods are disclosed herein for administering a oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2) inhibitor for treating autoimmune and/or glomerulonephritis-associated diseases, and in particular, Systemic Lupus Erythematosus (SLE).... Indiana University Research And Technology Corp

Privacy-preserving similar patient query systems and methods

Method including securely calculating, by a processor in electrical communication with a genome registry, an edit-distance between a query private genome and a second private genome, and securely calculating, by the processor, a set difference size between the query genome and the second private genome are disclosed. Systems capable of... Indiana University Research And Technology Corp

High torque density electric motor and/or generator

An electric motor is disclosed, comprising a stator and a rotor mounted relative to the stator to form a gap between a surface of the stator and a surface of the rotor, the gap having a width. One of the stator and the rotor is mounted for movement relative to... Indiana University Research And Technology Corp

Microrna therapy for pancreatic cancer

Methods for inhibiting pancreatic cancer cell migration and invasion are disclosed herein. Further, methods for inhibiting autophagy are disclosed. More particularly, as discussed herein, increasing miR-29 expression in the tumor microenvironment inhibits migration, invasion and autophagy in cancer patients.... Indiana University Research And Technology Corp

Device and analysis of biofluids by ion generation using wetted porous material

The present disclosure provides a mass spectrometry cartridge and methods of use thereof.... Indiana University Research And Technology Corp

External resource control of mobile devices

The present disclosure provides a security enhanced channel control system useable on a wireless device comprising a policy module including at least one processor and memory, the policy module configured to store, in the memory, one or more security policies and apply a compliance check to a first system layer... Indiana University Research And Technology Corp

Th17-prone cd146+ccr5+ t-cell population as an early marker of intestinal graft-versus-host disease

Th17-prone CD146+CCR5+ T-cell population as an early biomarker of intestinal graft-versus-host disease and its use for determining prognosis of intestinal GVHD before the clinical signs are apparent are disclosed.... Indiana University Research And Technology Corp

Culture conditions that allow zymomonas mobilis to assimilate n2 gas as a nitrogen source during bio-ethanol production

Chemically defined culture medium and culture conditions that allow bacteria to assimilate dinitrogen gas (N2) as a nitrogen source during bio-ethanol production are disclosed herein. Methods of bioethanol production using the chemically defined culture medium and culture conditions are also disclosed.... Indiana University Research And Technology Corp

Methods and systems for predicting bleeding risk and dose of plasminogen activator

The present disclosure provides a method and system for estimating the clinical responsiveness of a patient to a dose of a plasminogen activating agent to treat a thrombosis, comprising determining a concentration of α2-antiplasmin in a blood sample of the patient, determining a concentration of activated fibrinolysis inhibitor (“TAFI”) in... Indiana University Research And Technology Corp

Glucagon/glp-1 receptor co-agonists

Provided herein are peptides and variant peptides that exhibit enhanced activity at the GLP-1 receptor, as compared to native glucagon.... Indiana University Research And Technology Corp

Unified computational patient-specific hemodynamics

A method for computing patient-specific hemodynamics. The method includes receiving three dimensional imaging data of a patent, extracting anatomical data from the three dimensional imaging data, calculating velocity and pressure fields corresponding to the extracted anatomical data, and calculating displacement and velocity of extracted solid particles corresponding to the anatomical... Indiana University Research And Technology Corp

Multiband wavelength selective structure

A wavelength selective structure for selectively reflecting or absorbing incident electromagnetic visible or infrared radiation. The wavelength selective structure includes a wavelength selective structure with a plurality of layers, including a compound layer forming a plurality of surface elements, an electrically isolating intermediate layer, wherein the compound layer is in... Indiana University Research And Technology Corp

Pro-angiogenic and anti-angiogenic hematopoietic progenitor cell populations

Methods for identifying active angiogenesis and vasculopathy are described. More particularly, the present disclosure relates to cellular biomarkers, and to methods of screening cellular biomarkers for identifying active angiogenesis.... Indiana University Research And Technology Corp

Presentation of bioactive proteins

The invention provides a fusion protein comprising an antigen binding domain linked to a bacteriophage decoration (Dec) protein along with a polynucleotide comprising the nucleic acid sequence of the fusion protein and a vector comprising the polynucleotide. Additionally, the invention provides a composition comprising the fusion protein and a virus-like... Indiana University Research And Technology Corp

Poly-cyanostilbene macrocycles

The present disclosure concerns synthesis and anion binding features of poly-cyanostilbene macrocycles of Formula (I):... Indiana University Research And Technology Corp

Insulin receptor partial agonists

Disclosed herein are insulin analog conjugates comprising an insulin agonist covalently linked to an insulin antagonist peptide. The conjugates are high potency insulin agonists but with decreased maximal activity relative to the maximal activity of native insulin.... Indiana University Research And Technology Corp

Artificial antigen-presenting cells and methods for producing and using the same

Described herein are biomimetic Janus particles useful as artificial antigen presenting cells capable of activating T cells in vitro. “Bull's eye” ligand patterns mimicking either the native or reverse organization of the T cell immunological synapse are provided on the surface of nano- or micro-sized particles. Methods for activating T... Indiana University Research And Technology Corp

Hybrid ion mobility spectrometer

A hybrid ion mobility spectrometer includes a single-pass drift tube having an ion inlet and an ion outlet, a multiple-pass drift tube having an ion inlet and an ion outlet each coupled to the single pass drift tube between the ion inlet and the ion outlet thereof, and at least... Indiana University Research And Technology Corp

Biomarker for determining mitochondrial damage in friedreich's ataxia

Compositions and methods for screening for a disease or a disorder associated with a deficiency in frataxin in a subject using biomarkers for diseases or disorders associated with a deficiency in frataxin are disclosed. The compositions and methods include determining the acetylation status of mito-chondrial proteins. Also disclosed are methods... Indiana University Research And Technology Corp

Device and vibration of an implantable device

Devices for imparting vibration to implanted devices to reduce accumulation of biofilm thereon including a vibration tip, the vibration tip being sized and shaped to couple to a vibrator and receive a vibration therefrom, wherein the vibration tip is sized and shaped to conduct the vibration from the vibrator to... Indiana University Research And Technology Corp

Atraumatic selective surgical suction device and method

Suction devices are disclosed comprising a side wall defining a lumen, an open proximal end sized to provide coupling to a suction source, a distal wall opposite the open proximal end, the distal wall at least partially occluding the lumen, the side wall extending between the proximal end and the... Indiana University Research And Technology Corp

Incretin-insulin conjugates

Disclosed herein are insulin agonist peptides conjugated to incretins wherein the incretin-insulin conjugate has agonist activity at the insulin receptor and the corresponding incretin receptor, and stimulates weight loss in an individual administered the compound.... Indiana University Research And Technology Corp

Lipidated amide-based insulin prodrugs

Prodrug formulations of insulin and insulin analogs are provided wherein the insulin peptide has been modified by an amide bond linkage of a dipeptide prodrug element. The prodrugs disclosed herein have extended half-lives and are converted to the active form at physiological conditions through a non-enzymatic reaction driven by chemical... Indiana University Research And Technology Corp

Method and assessing tissue oxygenation saturation

A method and apparatus for assessing tissue oxygenation saturation during physical activity comprising the steps of providing at least one near-infrared spectroscopy probe including at least one near-infrared light source and at least one photodetector-and measuring oxygen saturation in at least one of a skin dermis layer, an adipose layer... Indiana University Research And Technology Corp

Methods and compositions for treating hepatitis b virus infections

Described herein are methods for identifying compounds useful for the treatment of infection by hepatitis B virus (HBV) and for identifying compounds useful for the same.... Indiana University Research And Technology Corp

Antithetical regulation of endothelial ace and ace2 by brg1-foxm1 complex underlies pathological cardiac hypertrophy

Methods are disclosed herein for administering a FoxM1 inhibitor for preventing, treating, and/or reducing cardiac hypertrophy and/or cardiac failure. Particularly, the methods are directed to the use of a FoxM1 inhibitor to block the function of FoxM1-Brg1 complex, thereby reversing the ACE/ACE2 expression ratio such to protect the heart from... Indiana University Research And Technology Corp

Salicylic acid derivatives, pharmaceutically acceptable salt thereof, composition thereof and use thereof

or a pharmaceutically acceptable salt, solvate or prodrug thereof.... Indiana University Research And Technology Corp

Biomarkers and assay to detect chronic graft versus host disease

A four-biomarker panel for diagnosis of chronic graft-versus-host disease (cGVHD) and methods of prognosing and/or diagnosing cGVHD using the biomarker panel are disclosed.... Indiana University Research And Technology Corp

Method and spatial cognitive assessment of a lab animal

The present disclosure relates to a method and apparatus for performing a cognitive bias assay on a lab animal. The apparatus may include a first base member and a second base member spaced apart from the first base member to form an interior region between the first and second base... Indiana University Research And Technology Corp

Transgenic pigs lacking one or more cellular transport genes

The application provides methods of improving a medication related side effect in a human after transplant of transgenic organs, tissues or cells from transgenic pigs with a disrupted cellular transport gene or genes, and porcine organs, tissues, and cells therefrom are provided.... Indiana University Research And Technology Corp

Methods for detecting sinusoidal obstructive syndrome (sos)

Disclosed are biomarker panels for evaluating subjects at risk of sinusoidal obstruction syndrome (SOS) early after hematopoietic stem cell transplantation (HSCT). In particular, the present disclosure relates to the use of one or more of ST2, ANG2, L-Ficolin, HA, and VCAM1 for prognosing, diagnosing, and/or treating SOS.... Indiana University Research And Technology Corp

08/24/17 / #20170239225

Combination therapies for treatment of spinal muscular atrophy

Disclosed herein are compositions and methods for treatment of spinal muscular atrophy (SMA). In certain embodiments, compounds are provided that increase full-length survival of motor neuron (SMN) protein production by an SMN2 gene.... Indiana University Research And Technology Corp

08/17/17 / #20170231548

System and bladder transducer placement

A tissue sensing device and a method for placing the device. The device including a first electrically conductive needle; a non-conductive sheath receiving the first needle therein and allowing exposure of a portion the first needle at a distal end thereof; a second electrically conductive needle; and electronics coupled to... Indiana University Research And Technology Corp

08/10/17 / #20170226121

Modulators of virus assembly as antiviral agents

In addition to containing and protecting the viral genome, the capsid (protein shell) of hepatitis B virus (HBV) plays critical roles in the viral life cycle including regulation of intracellular trafficking and nucleic acid metabolism. Substituted pyrimidine modulators of the assembly of the HBV capsid structure and methods for their... Indiana University Research And Technology Corp

08/10/17 / #20170227147

Conduit identification tags

An identifier for a conduit includes a first tag having a body with a first aperture formed therein for receiving the conduit and a first identifying feature, and a second tag having a body with a second aperture formed therein for receiving the conduit and a second identifying feature that... Indiana University Research And Technology Corp

08/03/17 / #20170220743

Tracking real-time assessment of quality monitoring in endoscopy

The present disclosure provides a method for making clinical recommendations, comprising receiving pathology reports by a computing device; processing the pathology reports by the computing device using natural language processing software, including a custom pathology dictionary; generating, using the computing device, a document based on the processing of the pathology... Indiana University Research And Technology Corp

07/27/17 / #20170211039

Method for producing retinal ganglion cells from pluripotent cells

A method of making retinal ganglion cells, comprises the steps of: (a) differentiating pluripotent stem cells into retinal progenitor cells; and, (b) differentiating retinal progenitor cells into retinal ganglion cells.... Indiana University Research And Technology Corp

07/06/17 / #20170189362

Tuneable delivery of nanoparticle bound active plasmin for the treatment of thrombosis

Compositions and methods for therapeutic delivery are disclosed. More particularly, the present disclosure relates to nanoparticle compositions that sequester the activity of a target molecule while leaving other domains accessible to bind targeted tissues of interest. Methods for thrombus dissolution include administering a nanoparticle reversibly coupled to a target molecule... Indiana University Research And Technology Corp

07/06/17 / #20170191963

Ion mobility spectrometer and operating same

An ion mobility spectrometer instrument has a drift tube that is partitioned into a plurality of cascaded drift tube segments. A number of electric field sources may each be coupled to one or more of the plurality of drift tube segments. A control circuit is configured to control operation of... Indiana University Research And Technology Corp

06/29/17 / #20170182055

Materials and inhibiting replication protein a and uses thereof

Targeting uncontrolled cell proliferation and resistance to DNA damaging chemotherapeutics with at least one reagent has significant potential in cancer treatment. Replication Protein A, the eukaryotic single-strand (ss) DNA binding protein, is essential for genomic maintenance and stability via roles in both DNA replication and repair. Reported herein are small... Indiana University Research And Technology Corp

06/15/17 / #20170170487

Systems and methods of graphene supported catalysts

Functionalized graphene comprising graphene, a metal dispersed throughout the graphene, wherein the metal comprises Pt, Rh, Pd, Ag, Au, Ni, Os, Ir, alloys thereof, oxides thereof, or mixtures thereof, and a first functional group covalently bonded to the graphene, wherein the first functional group comprises sulfonate, SO3−, Carboxylate, COO−, a... Indiana University Research And Technology Corp

06/08/17 / #20170157426

System and reducing biological damage in proton therapy

Systems comprising a processor in electrical communication with a tangible, non-transitory memory that, in response to an execution by the processor, cause the processor to measure a relative biological effectiveness of a beam on a region of a human body, and a beam applicator in electrical communication with the processor,... Indiana University Research And Technology Corp

06/01/17 / #20170155129

High-energy rechargeable lithium-sulfur batteries

Methods of manufacturing comprising placing a mixture comprising sulfur powder, a carbon nanotube, an alcohol soluble binder, and a solvent into a cast and removing a solvent from the mixture to form an electrode are disclosed. Electrodes and batteries comprising sulfur, a carbon nanotube, and an alcohol soluble binder are... Indiana University Research And Technology Corp

05/25/17 / #20170148097

Systems and methods for deriving financial information from emotional content analysis

Method of deriving financial information comprising gathering, by a processor, information from a plurality of social media accounts, associating, by the processor, the information from the plurality of social media accounts with a firm, determining an excitement value for the information gathered from each of the plurality of social media... Indiana University Research And Technology Corp

05/04/17 / #20170123092

Systems and methods for detection of well properties

Methods comprising electronically receiving information of a reflection of a known first sound pulse, electronically receiving information of a reflection of a known second sound pulse, determining, by a processor, a change in a first property between a known first sound pulse and a reflection of the known first sound... Indiana University Research And Technology Corp

04/20/17 / #20170105710

System and extracting tissue samples

A method and apparatus for extracting tissue samples are disclosed herein. An example apparatus disclosed herein includes a first sidewall and a second sidewall spaced apart from the first sidewall. The example apparatus also includes a track to receive a blade between the first sidewall and the second sidewall. The... Indiana University Research And Technology Corp

04/20/17 / #20170108512

Use of biomarkers for detection of excessive alcohol use

Methods of diagnosing excessive alcohol use are disclosed herein. More particularly, the present disclosure is directed to methods of diagnosing excessive alcohol use by identifying expression levels of various serum biomarkers. In some embodiments, expression levels of these biomarkers are affected by alcohol use even up to 30 days after... Indiana University Research And Technology Corp

03/23/17 / #20170080055

Hematopoitetic growth factor proteins and analogs thereof and angiotensin converting enzyme inhibitors for treatment of radiation exposure

Methods and compositions comprising hematopoietic growth factor proteins and/or protein analogs thereof and/or combinations thereof and angiotensin converting enzyme inhibitors to treat the acute and long term adverse effects of radiation exposure in subjects who have been or will be exposed to radiation are disclosed.... Indiana University Research And Technology Corp

03/23/17 / #20170081378

Peptide antagonist of ll-37

This disclosure is related to the peptide antagonist of LL-37, an antimicrobial peptide that has multiple functions in both innate and adaptive immune response. Specifically, the identified peptide antagonists of LL-37 provide inhibition to detrimental autoimmune inflammatory response, whereas at the same time retain LL-37's antibacterial activity.... Indiana University Research And Technology Corp

03/16/17 / #20170078559

Three dimensional moving pictures with a single imager and microfluidic lens

A method and system for determining depth of an image using a single imager and a lens having a variable focal length is provided. The system comprises a microfluidic lens having a variable focal length controlled by a lens controller and an imager receiving an image of an object from... Indiana University Research And Technology Corp

03/09/17 / #20170067053

Methods for preventing and treating chronic kidney disease (ckd)

The present invention relates to methods for preventing and treating chronic kidney disease (CKD).... Indiana University Research And Technology Corp

03/02/17 / #20170059433

Supersensitive linear pressure transducer

Apparatus and methods for a MEMS-fabricated variable capacitor. In one embodiment the capacitor is a comb drive comprising a plurality of plates interdigitated with a corresponding blades. As the plates move relative to the blades, the capacitance of the sensor changes. The capacitor is sufficiently sensitive to measure respiratory pressure... Indiana University Research And Technology Corp

02/16/17 / #20170044097

Antibacterials and/or modulators of biofilm formation and methods of using the same

Amides substituted with aromatic groups were synthesized and some were purified to create enantiomer pure compounds. The compounds were tested to determine their ability to inhibit the growth of bacteria and the formation of biofilms created by bacteria. Some of these compounds were found to be effective antibacterials and to... Indiana University Research And Technology Corp

02/16/17 / #20170044485

Materials and methods for identifying and using yeast strains that metabolize pentose sugars in the presence of d-glucose

Disclosed herein are materials and methods for creating and/or isolating variants of yeasts especially variants of Saccharomyces cerevisiae that can grow on sugars other than D-glucose in the presence of amounts of 2-deoxy-glucose and or D-glucose that inhibit most strains of yeast from growing on sugars other than D-glucose. Selection... Indiana University Research And Technology Corp

02/09/17 / #20170035782

Modulation of inflammation using progesterone metabolites

Methods for modulating inflammation using progesterone metabolites are disclosed. More particularly, methods of administering progesterone metabolites, 6β-hydroxyprogesterone (6β-OHP) and 16α-hydroxyprogesterone (16α-OHP) are disclosed for mitigating inflammation in various tissue types in the body.... Indiana University Research And Technology Corp

02/02/17 / #20170029907

Generalizable assay for virus capsid assembly

Virus capsids protect the viral genome and play roles in its delivery and intracellular transport, making them an attractive target for antiviral therapeutics. The difficulty in targetting capsid assembly is to identify molecules that interfere with the weak protein-protein interactions that drive the reaction. We have developed an in vitro... Indiana University Research And Technology Corp

02/02/17 / #20170030916

Materials and methods for diagnosing and predicting the course of prostate cancer

Expression of Forkhead-box protein A1 (FOXA1), a transcription factor important for the normal development of the prostate gland is thought to be controlled by steroid hormones and GATA-3. Expression of FOXA1, GATA-3 and androgen receptor (AR) was retrospectively analyzed by immunohistochemistry (IHC) in a series of 80 primary tumors and... Indiana University Research And Technology Corp

01/26/17 / #20170022476

Method for generating endothelial colony forming cell-like cells

The present disclosure relates generally to methods and compositions useful in cell and tissue biology and therapeutics. In particular, an in vitro method for differentiating pluripotent cells into endothelial colony forming cell-like cells (ECFC-like cells) is provided. A purified human cell population of NRP-1+CD31+ ECFC-like cells is provided, wherein at... Indiana University Research And Technology Corp

01/05/17 / #20170005328

Novel carbonized polyaniline-grafted silicon nanoparticles encapsulated in graphene sheets for li-ion battery anodes

A method for producing a graphene-composite material, including removing any oxide layer from each of a plurality of silicon nanoparticles, forming a polyaniline layer over each clean silicon nanoparticle, binding a graphene oxide sheet to the polyaniline layer of each particle, and carbonizing the polyaniline to yield a plurality of... Indiana University Research And Technology Corp

02/22/18 / #20180051297

Compositions and systems for conferring disease resistance in plants and methods of use thereof

Compositions, systems and methods are provided for conferring disease resistance to plant pathogens that use proteases to target plant substrate proteins inside plant cells. Briefly, the compositions, systems and methods are based upon plant substrate proteins that are targeted by pathogen-specific proteases and that activate nucleotide binding site-leucine rich repeat... Indiana University Research And Technology Corp

11/23/17 / #20170337327

Unified computational patient-specific hemodynamics

A method for computing patient-specific hemodynamics. The method includes receiving three dimensional imaging data of a patent, extracting anatomical data from the three dimensional imaging data, calculating velocity and pressure fields corresponding to the extracted anatomical data, and calculating displacement and velocity of extracted solid particles corresponding to the anatomical... Indiana University Research And Technology Corp

Patent Packs
06/08/17 / #20170157426

System and reducing biological damage in proton therapy

Systems comprising a processor in electrical communication with a tangible, non-transitory memory that, in response to an execution by the processor, cause the processor to measure a relative biological effectiveness of a beam on a region of a human body, and a beam applicator in electrical communication with the processor,... Indiana University Research And Technology Corp








ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009



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