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Institut National De La Sante Et De La Recherche Medicale inserm
Institut National De La Sante Et De La Recherche Medicale inserm fr fr
Institut National De La Sante Et De La Recherche Medicale inserm_20100121

Institut National De La Sante Et De La Recherche Medicale inserm patents


Recent patent applications related to Institut National De La Sante Et De La Recherche Medicale inserm. Institut National De La Sante Et De La Recherche Medicale inserm is listed as an Agent/Assignee. Note: Institut National De La Sante Et De La Recherche Medicale inserm may have other listings under different names/spellings. We're not affiliated with Institut National De La Sante Et De La Recherche Medicale inserm, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "I" | Institut National De La Sante Et De La Recherche Medicale inserm-related inventors


Tetrahydroquinoline derivatives and their use as epac inhibitors

The invention relates to tetrahydroquinoline derivatives and their use in the treatment and/or the prevention of a disease wherein the Epac protein is involved, such as inflammation, cancer, vascular diseases, kidney diseases, cognitive disorders and cardiac diseases.... Institut National De La Sante Et De La Recherche Medicale inserm

Anti-mesothelin antibodies and uses thereof

The present disclosure provides isolated nanobodies based on camelid VHH domains that specifically bind to mesothelin with high affinity. Also disclosed are conjugate constructs comprising the isolated nanobodies derivatized to allow conjugation to or that are conjugated to accessory moieties, such as biologically active moieties (e.g., a cytotoxin, a non-cytotoxic... Institut National De La Sante Et De La Recherche Medicale inserm

Process and device for separating biological particles contained in a fluid by means of filtration

The invention relates to a method of separating biological particles from the liquid containing same for purification, analysis and optionally diagnostic purposes. The inventive method comprises at least one step involving vertical filtration through a filter having a porosity that is adapted to the type of biological particles to be... Institut National De La Sante Et De La Recherche Medicale inserm

Anti il-34 antibodies

The present disclosure relates to novel anti IL-34 antibodies or antigen-binding fragments thereof specifically binding cytokine IL-34 with high affinity, the method of obtaining of these antibodies and their therapeutic use.... Institut National De La Sante Et De La Recherche Medicale inserm

Fibroblast growth factor receptors as diagnostic markers of acquired sensory neuronopathies

The present invention relates to the diagnosis of acquired sensory neuronopathies (SNN), and to the treatment of these disorders.... Institut National De La Sante Et De La Recherche Medicale inserm

Method of culturing segmented filamentous bacteria in vitro

The present invention relates to an in vitro method of culturing a segmented filamentous bacterium strain, comprising co-culturing said segmented filamentous bacterium strain with a eukaryotic host cell, wherein the culture is performed at an O2 level inferior to 5% in a rich tissue culture liquid medium containing bacterial medium... Institut National De La Sante Et De La Recherche Medicale inserm

Use of a reverse-transcriptase inhibitor in the prevention and treatment of degenerative diseases

The invention relates to the use of a reverse-transcriptase inhibitor in the prevention or treatment of a degenerative disease.... Institut National De La Sante Et De La Recherche Medicale inserm

Flt3 receptor antagonists for the treatment or the prevention of pain disorders

The present invention relates to FLT3 receptor antagonists or inhibitors of FLT3 receptor gene expression for the treatment or the prevention of pain disorders.... Institut National De La Sante Et De La Recherche Medicale inserm

Anti-angiogenic properties of collagen v derived fragments

The present invention relates to a peptide comprising an amino acid sequence at least 85% identical to the amino acid sequence as shown in SEQ ID NO. 1, wherein the residues Lys905, Arg909, and Arg912 contained therein are present, for use as a medicament, in particular for its use as... Institut National De La Sante Et De La Recherche Medicale inserm

Porous polysaccharide scaffold comprising nano-hydroxyapatite and use for bone formation

The present invention relate to three dimensional porous polysaccharide matrices able to induce mineralisation of a tissue in osseous site, as well as in non-osseous site, in the absence of stem cells or growth factors.... Institut National De La Sante Et De La Recherche Medicale inserm

Diagnostic of obliterative arteriopathies

The invention relates to a method of diagnosis or prognosis of an obliterative arteriopathy in a subject, comprising determining the expression level of adenosine A2A receptors expressed at the cell surface of peripheral blood mononuclear cells obtained from said subject. The invention also relates to an agonist-like monoclonal antibody directed... Institut National De La Sante Et De La Recherche Medicale inserm

Time-controlled glucose releasing hydrogels and applications thereof

The present invention relates generally to a hydrogel releasing glucose in a time-controlled manner, to medical applications thereof, and to a method for preparing said hydrogel.... Institut National De La Sante Et De La Recherche Medicale inserm

Novel aminopyridine compounds useful as inhibitors of protein prenylation

group. Also disclosed are novel compounds of formulae (I) and (II).... Institut National De La Sante Et De La Recherche Medicale inserm

Mutant bordetella strains and methods of use

A method of reducing or preventing the development of airway inflammation in a subject includes the step of infecting the respiratory tract of a subject an amount of a composition including a pharmaceutically acceptable carrier and live attenuated pertactin-deficient Bordetella bacteria sufficient to colonize the respiratory tract of the subject.... Institut National De La Sante Et De La Recherche Medicale inserm

Nitrogen-containing analogs of salinomycin, synthesis and use against cancer stem cells and malaria

The present invention concerns compounds of formula (I), enantiomers, mixture of enantiomers, diastereoisomers and mixture of diasteroisomers thereof formula (I): wherein at least one of W, X and Y is selected from the group consisting of —NR1R2; —NR3—(CH2)n—NR4R5; —O—(CH2)n—NR4R5; —NR3—(CH2)n—N′R6R7R8; and —O—(CH2)n—N′R6R7R8 and Z is a functional group capable of... Institut National De La Sante Et De La Recherche Medicale inserm

Microfluidic device with one microchannel for multiple detection

The present invention relates to a microfluidic device (2) comprising a support part (21) and a cover part (22) defining together a microchannel (5), said microchannel (5) having a surface, said surface comprising:—a first area (9) which is grafted with a first ligand, and—at least a second area (10) which... Institut National De La Sante Et De La Recherche Medicale inserm

Bola-amphiphilic compounds and their uses for biomedical applications

The invention relates to bola-amphiphilic compounds and their uses for biomedical application. The invention particularly relates to the use of bola-amphiphilic compounds for providing low molecular weight gels (LMWG), useful, in particular, as culture media for animal or human cells, or as biocompatible material for biomedical applications.... Institut National De La Sante Et De La Recherche Medicale inserm

Method for correcting an infrared absorption spectrum

A method for correcting an infrared absorption spectrum comprises the steps of:—providing a measured infrared absorption spectrum from a sample,—determining a baseline correction curve by using at least one spectral interval in which an absorption quantity is expected to be null for at least two wavelength quantities,—subtracting the baseline correction... Institut National De La Sante Et De La Recherche Medicale inserm

Methods and tools for detecting interactions in eukaryotic cells using microtubule structures and dynamics

A method for detecting an interaction between one or more protein bait and one or more candidate prey in a eukaryotic cell, comprising the steps of: a) providing an eukaryotic cell expressing (i) one or more protein bait, and (ii) one or more candidate prey, wherein said protein bait comprises... Institut National De La Sante Et De La Recherche Medicale inserm

Compositions useful in the diagnostic of latently infected mycobacterium tuberculosis

The present invention concerns a composition comprising at least three peptides derived from Mycobacterium tuberculosis antigen Rv2626c, its use in the diagnostic of latently infected Mycobacterium tuberculosis (LTBI) subjects, corresponding methods of use and kits.... Institut National De La Sante Et De La Recherche Medicale inserm

Method for determining the characteristics of a system for generating a spatial light modulation in phase and amplitude at high refresh rate

Method for determining the characteristics of a system for generating at least one pattern of light, the method comprising: a) providing a desired pattern of light, b) expressing the amplitude and the phase of the output pulse of the system as a function of the input laser pulse and in... Institut National De La Sante Et De La Recherche Medicale inserm

Method for determining absorption bands

The present invention concerns a method for determining at least one absorption band in a spectrum, the method at least comprising the steps of:—providing a measured absorption spectrum from the sample,—providing a calculation spectrum,—from the calculation spectrum, extracting at least one absorption band,—calculating a residual spectrum by removing each extracted... Institut National De La Sante Et De La Recherche Medicale inserm

Methods for the treatment of tinnitus induced by cochlear excitotoxicity

The invention relates to methods for the prevention and/or treatment of tinnitus induced by cochlear excitotoxicity. In these methods, a pharmaceutical composition comprising an NMDA receptor antagonist is administered to an individual in need of such treatment by appropriate devices and/or formulations for local administration to the inner ear. The... Institut National De La Sante Et De La Recherche Medicale inserm

Population of immunoregulatory t cells specific for an irrelevant antigen and uses thereof for preventing or treating immune diseases

The present invention relates methods and compositions for preventing or treating various immune diseases including graft-versus-host disease (GVHD) using populations or compositions of immunoregulatory T cells specific for an irrelevant antigen; such cells being activated in vivo by a simultaneous, separate or sequential administration of said antigen.... Institut National De La Sante Et De La Recherche Medicale inserm

Capped and uncapped rna molecules and block copolymers for intracellular delivery of rna

The present invention relates to the use of at least one tetra functional non-ionic amphiphilic block copolymer as a vehicle for capped or uncapped mRNA for intracellular delivery for gene therapy.... Institut National De La Sante Et De La Recherche Medicale inserm

Macrocyclic complexes, their process of preparation and use as pet imaging agents

The present invention concerns compounds of formula (I): their process of preparation and compositions thereof. The present invention also concerns their use as diagnostic agent in PET imaging.... Institut National De La Sante Et De La Recherche Medicale inserm

Method for obtaining a functional parameter of a muscle

The present invention concerns a method for obtaining a functional parameter of a muscle having a part, the method comprising the steps of: a) applying ultrasound waves to the muscle, b) collecting the ultrasound waves retrodiffused by the muscle at a plurality of times, to obtain collected ultrasound waves, c)... Institut National De La Sante Et De La Recherche Medicale inserm

Cyclic compounds having a 1,3 diamino-functionality for use in the treatment of hiv infection

The present invention relates to compounds, capable of activating HIV expression in reservoir cells, of formula (I) for use in the treatment of HIV infection.... Institut National De La Sante Et De La Recherche Medicale inserm

Fumarate-co-releasing molecule hybrids, their use in the treatment of inflammatory or cardiovascular diseases and their process of preparation

The present invention relates to hybrid fumarate-CO-releasing molecules capable of increasing heme oxygenase-1 (HO-1) activity and HO-1 protein expression and simultaneously releasing CO, their synthesis and their use in therapeutic applications, in particular their use in the treatment of inflammatory or cardiovascular diseases.... Institut National De La Sante Et De La Recherche Medicale inserm

Diagnosis of hereditary spastic paraplegias (hsp) by detection of a mutation in the kiaa1840 gene or protein

An ex vivo method of diagnosing or predicting an hereditary spastic paraplegias (HSP) in a subject is provided which comprises detecting a mutation in the KIAA1840 gene or protein (spatacsin), wherein that mutation is indicative of an hereditary spastic paraplegias (HSP).... Institut National De La Sante Et De La Recherche Medicale inserm

Recombinant monovalent antibodies

The invention relates to recombinant monovalent antibodies which are heterodimers of a first protein chain comprising the variable domain of the heavy chain of an antibody of interest and the CH2 and CH3 domains of an IgG immunoglobulin and a second protein chain comprising the variable domain of the light... Institut National De La Sante Et De La Recherche Medicale inserm

Polypeptide derived from gp41, a vaccine composition comprising said polypeptide, and uses for treating an infection by an hiv virus in an individual

The present invention relates to the field of the in vitro diagnosis of the progression status of an infection of an individual with a virus belonging to the family of the Human Immunodeficiency Viruses (HIV) as well as with the therapeutical treatment of this infectious disease. The invention also relates... Institut National De La Sante Et De La Recherche Medicale inserm

Method of characterizing molecular diffusion within a body from a set of diffusion-weighted magnetic resonance signals and carrying out such a method

A computer-implemented method of characterizing molecular diffusion within a body from a set of diffusion-weighted magnetic resonance signals by computing a weighted average of a plurality of multi-compartment diffusion models comprises a same number of compartments, fitted to a set of diffusion-weighted magnetic resonance signals, the weighted average being computed... Institut National De La Sante Et De La Recherche Medicale inserm

Anti-cd28 humanized antibodies

The invention relates to humanized antibodies directed against the human lymphocyte receptor CD28. When used in a monovalent form these antibodies are antagonists, i.e. capable of blocking of the CD28/B7 interaction, without activating CD28. These antibodies can be used in particular as therapeutic agents for blocking T cell activation through... Institut National De La Sante Et De La Recherche Medicale inserm

Influenza vaccine, composition, and methods of use

The invention relates to compositions and vaccines that include a mutated Bordetella strain for treating or preventing an influenza infection in a mammal. In addition, the invention further provides methods for protecting a mammal against infection by influenza and/or eliciting an immune response against an influenza virus in a mammal... Institut National De La Sante Et De La Recherche Medicale inserm

03/16/17 / #20170073637

Pooled nk cells from ombilical cord blood and their uses for the treatment of cancer and chronic infectious disease

The invention relates to the field of cell therapy, particularly NK cell mediated therapy. The present invention relates to a method of producing an ex vivo population of cells, preferably NK cells, from at least two umbilical cord blood units (UCB units), or fraction thereof containing said cells, by pooling... Institut National De La Sante Et De La Recherche Medicale inserm

03/16/17 / #20170074891

Detection of shed cd31, diagnosis of atherothrombosis and autoimmune disorders, and methods for analyzing signaling pathways

The present invention stems from the finding that the extracellular domain of CD31 proteins present on blood leukocytes is shed and released in the circulation as a soluble form of CD31. A method for detecting shed CD31 is further disclosed. The invention therefore relates to a method for detecting a... Institut National De La Sante Et De La Recherche Medicale inserm

03/09/17 / #20170067910

Detection of platelet-derived shed cd31

The present invention relates to various soluble forms of CD31, including a novel form which is shed by activated platelets and released into the circulation. Methods for detecting said soluble forms of CD31 are disclosed, as are methods of specifically 1 detecting said platelet-derived shed CD31 and the use of... Institut National De La Sante Et De La Recherche Medicale inserm

03/02/17 / #20170056500

Fkbp52-tau interaction as a novel therapeutical target for treating the neurological disorders involving tau dysfunction

The invention relates generally to neuroprotection and repair in neurological disorders involving Tan dysfunction (including Alzheimer's disease). The invention describes AND INCLUDES a direct interaction between proteins FKBP52 mid Tau. More particularly, the invention relates to a method for screening a drug for the prevention and treatment of neurological disorders... Institut National De La Sante Et De La Recherche Medicale inserm

02/23/17 / #20170051253

Method and device for conserving viable and functional human polymorphonuclear neutrophils

A method for keeping leukocytes alive ex vivo or in vitro, comprising maintaining the leukocytes in a medium comprising from 3 to 10 mM of glucose, in hypoxic conditions with P(02)≦10 mM Hg.... Institut National De La Sante Et De La Recherche Medicale inserm

02/09/17 / #20170037067

New lipophenol compounds and uses thereof

The present invention relates to a compound of formula (I) wherein: —i is 0 or 1; j is 0 or 1; k is 0 or 1; —R1 and R2 are in particular H, (C1-C12)alkyl, or a group of formula C(O)R; —R is a, linear or branched, alkyl radical, comprising at... Institut National De La Sante Et De La Recherche Medicale inserm

02/02/17 / #20170028006

Use of cranberry proanthocyanidin for treatment of oropharyngeal bacterial colonization

The present invention relates to a method for preventing Gram-negative bacterial colonization of an oropharyngeal material, the said method comprising bringing into contact a composition comprising a cranberry-derived proanthocyanidin extract on at least a part of the surface area of the said material.... Institut National De La Sante Et De La Recherche Medicale inserm

01/05/17 / #20170000846

Use of a neurofilament peptide for the treatment of glioma

The present invention provides a new drug to treat malignant glioma, which is the most prevalent type of primary tumor of the central nervous system (CNS). The present invention indeed shows that the isolated NFL-TBS40-63 peptide is highly specific for glioma cells, in which it triggers apoptosis. It is therefore... Institut National De La Sante Et De La Recherche Medicale inserm

01/05/17 / #20170000849

Cd300a receptors as virus entry cofactors

The present invention concerns an inhibitor of an interaction between CD300a and an aminophospholipid for use in preventing or treating a virus infection by inhibition of the interaction between CD300a and viral aminophospholipid.... Institut National De La Sante Et De La Recherche Medicale inserm








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