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Lonza Ltd patents


Recent patent applications related to Lonza Ltd. Lonza Ltd is listed as an Agent/Assignee. Note: Lonza Ltd may have other listings under different names/spellings. We're not affiliated with Lonza Ltd, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "L" | Lonza Ltd-related inventors


 new patent  Method for preparation of bis(fluorosulfonyl)-imide

The invention relates to a method for the preparation of bis(fluorosulfonyl)-imide and its derivatives at elevated temperature.. . ... Lonza Ltd

Expression sequences

An isolated nucleic acid encoding a leader, which has a specific sequence, an isolated leader peptide encoded by such nucleic acid, an expression cassette comprising such nucleic acid encoding a leader operably linked to a nucleic acid sequence encoding a poi, a recombinant yeast host cell or a vector comprising such expression cassette, a method of producing a poi in such yeast host cell, and further the use of the specific nucleic acid for the secretion of a poi from a host cell and/or to increase the secretion of a poi from a host cell.. . ... Lonza Ltd

Reactor surface finish remediation

Improved biopharmaceutical processing equipment such as reactor vessels and stainless steel surfaces, and methods of determining the same are disclosed herein. In some embodiments, a biopharmaceutical processing equipment can include a vessel having a surface that is configured to contact proteinaceous processing material, wherein the surface has a pre-commissioning surface roughness of greater than about 20 ra max (μin).. ... Lonza Ltd

Method and system for providing buffer solutions

A method for delivering a processing solution includes providing a concentrated processing solution in a bioprocess container, the concentrated processing solution being produced at a first site. The method also includes combining the concentrated processing solution with a biopolymer containing solution produced in a bioreactor at a second site different from the first site. ... Lonza Ltd

Bioreactor with higher agitation rates

A single-use bioreactor is provided. The single-use bioreactor may include a bioprocess container, a shell, at least one agitator, at least one sparger, at least one gas filter inlet port for the sparger(s) and headspace overlay, at least one fill port, at least one harvest port, at least one sample port, and at least one probe. ... Lonza Ltd

Method for stabilizing proteins

The present disclosure features methods and compositions for increasing the amount of products of cellular metabolism, e.g., proteins, by lowering the temperature of cells expressing the product at one or more steps while culturing the cells, expressing the product, and/or recovering the product.. . ... Lonza Ltd

Single use bioreactor

A single-use bioreactor is provided. The single-use bioreactor may include a bioprocess container, a shell, at least one agitator, at least one sparger, at least one gas filter inlet port for the sparger(s) and headspace overlay, at least one fill port, at least one harvest port, at least one sample port, and at least one probe. ... Lonza Ltd

Fluid mixing structure, continuous reaction unit, continuous reaction reactor and method of using the same

A fluid mixing structure (10) for mixing at least two fluidic components has a flow inlet port and a flow outlet port and comprises a contraction zone (12), an expansion zone (14), and a retention zone (16), arranged in this order in an inflow direction (ifd) of a fluid flow to flow through said fluid mixing structure (10) and being composed of said at least two fluidic components, and a flow splitter (32) arranged in a space (30) formed by said expansion zone (14) and said retention zone (16) to split said fluid flow in a first sub fluid flow and a second sub fluid flow flowing in a first flow path and a second flow path, respectively, formed in the fluid mixing structure, and to mix said first and second sub fluid flows within said space (30) to generate and discharge a homogenized fluid flow, wherein said flow splitter (32) is arranged and configured to let any flow element of each of said first and second sub fluid flows prior to their mixing have a non-zero average flow component in said inflow direction (ifd).. . ... Lonza Ltd

Customizable facility

A campus for fabricating at least one pharmaceutical product has one or more customizable facilities each configured to manufacture the at least one pharmaceutical product, a media/buffer plant, and a utility building connected by a utility line to the media/buffer plant and/or the one or more customizable facilities to provide at least one first utility to the media/buffer plant and/or the one or more customizable facilities via the utility line.. . ... Lonza Ltd

Modulation of lipid metabolism for protein production

The present disclosure features methods and compositions for modulating lipid metabolism to achieve improved production and quality of recombinant products, such as next generation biologics. Modulation of lipid metabolism as described herein includes, for example, introducing a lipid metabolism modulator described herein to a cell or a cell-free system. ... Lonza Ltd

Method for preparation of fluoro, chloro and fluorochloro alkylated compounds by homogeneous catalysis

The invention discloses a method for preparation of fluoro, chloro and fluorochloro alkylated compounds by homogeneous pd catalyzed fluoro, chloro and fluorochloro alkylation with fluoro, chloro and fluorochloroalkyl halides in the presence of di(1-adamantyl)-n-butylphosphine and in the presence of 2,2,6,6-tetramethylpiperidine 1-oxyl.. . ... Lonza Ltd

Customizable facility

A customizable facility for manufacturing at least one product has at least one modular unit in communication with at least one central unit configured to provide utilities to the at least one modular unit. In some embodiments, the central unit(s) and modular unit(s) are positioned at least partially within a shell. ... Lonza Ltd

Method for preparation of alkylated or fluoro, chloro and fluorochloro alkylated compounds by heterogeneous catalysis

The invention discloses a method for preparation of alkylated or fluoro, chloro and fluorochloro alkylated compounds by a heterogeneous pt/c-catalyzed alkylation or fluoro, chloro and fluorochloro alkylation with alkyl halides or with fluoro, chloro and fluorochloro alkyl halides in the presence of cs2c03 or cshc03.. . ... Lonza Ltd

Method for preparation of 4-alkoxy-1,1,1-trifluorobut-3-en-2-ones from 1,1,1-trifluoroacetone

The invention discloses a method for the preparation of 4-alkoxy-1,1,1-trifluorobut-3-en-2-ones from 1,1,1-trifluoroacetone.. . ... Lonza Ltd

02/16/17 / #20170044557

Recombinant host cell for expressing proteins of interest

The present invention is in the field of recombinant biotechnology, in particular in the field of protein expression. The invention generally relates to a method of expressing a protein of interest (poi) from a host cell. ... Lonza Ltd

02/09/17 / #20170037418

Regulatable promoter

A method of producing a protein of interest (poi) by culturing a recombinant eukaryotic cell line comprising an expression construct comprising a regulatable promoter and a nucleic acid molecule encoding a poi under the transcriptional control of said promoter, comprising the steps a) cultivating the cell line with a basal carbon source repressing the promoter, b) cultivating the cell line with a limited amount of a supplemental carbon source de-repressing the promoter to induce production of the poi at a transcription rate or at least 15% as compared to the native pgap promoter, and c) producing and recovering the poi; and further an isolated regulatable promoter and a respective expression system.. . ... Lonza Ltd

02/02/17 / #20170029827

Recombinant host cell engineered to overexpress helper proteins

The present invention is in the field of recombinant biotechnology, in particular in the field of protein expression. The invention generally relates to a method of expressing a protein of interest (poi) from a host cell. ... Lonza Ltd








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