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Los Alamos National Security Llc
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Los Alamos National Security Llc patents


Recent patent applications related to Los Alamos National Security Llc. Los Alamos National Security Llc is listed as an Agent/Assignee. Note: Los Alamos National Security Llc may have other listings under different names/spellings. We're not affiliated with Los Alamos National Security Llc, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "L" | Los Alamos National Security Llc-related inventors


 new patent  Path scanning for the detection of anomalous subgraphs and use of dns requests and host agents for anomaly/change detection and network situational awareness

A system, apparatus, computer-readable medium, and computer-implemented method are provided for detecting anomalous behavior in a network. Historical parameters of the network are determined in order to determine normal activity levels. A plurality of paths in the network are enumerated as part of a graph representing the network, where each... Los Alamos National Security Llc

Ultrasonic in-situ water-cut measurement using ultrasonic oil-water separation for affecting sound speed calibration

An apparatus and method for the separation of an oil-water mixture into its components are described. An acoustic radiation force moves oil droplets to the nodes of an acoustic standing wave generated in a vertical column containing the oil-water mixture. Once the droplets are sufficiently close together, attractive forces become... Los Alamos National Security Llc

System and automated extraction of high resolution structural dynamics from video

A method for extracting vibrational modes of a structure includes: receiving a plurality of video frames, each of the video frames including a plurality of pixels; decomposing each of the video frames on a plurality of spatial scales in accordance with complex steerable pyramid filters to obtain a filter response... Los Alamos National Security Llc

Devices for cell culture and methods of making and using the same

Devices and systems for cell culture that include one or more hollow fibers or channels integrated into a chamber are provided. The hollow fibers or channels and/or the chamber are seeded with one or more cell types. Methods of co-culturing two or more cell types in the devices are also... Los Alamos National Security Llc

Source identification by non-negative matrix factorization combined with semi-supervised clustering

Machine-learning methods and apparatus are provided to solve blind source separation problems with an unknown number of sources and having a signal propagation model with features such as wave-like propagation, medium-dependent velocity, attenuation, diffusion, and/or advection, between sources and sensors. In exemplary embodiments, multiple trials of non-negative matrix factorization are... Los Alamos National Security Llc

Crystalline perovskite thin films and devices that include the films

Hybrid organic-inorganic perovskite thin films with average grain sizes of at least 50 micrometers were prepared and employed in solar cells. The PCE values of the solar cells did not degrade with the direction or the scan-rate of the applied voltage. The larger average grain sizes are believed to assist... Los Alamos National Security Llc

Patterned neuromuscular junctions and methods of use

Disclosed herein are devices including a substrate, one or more regions of electrically active material, and optionally at least one electrode. Also disclosed herein are devices or systems including a substrate, one or more regions of electrically active material including muscle cells and neuronal cells, and optionally at least one... Los Alamos National Security Llc

Apparatus for preparing medical radioisotopes

Apparatus for radioisotope production includes housing, a plurality of target disks inside the housing and a curved windows positioned convex inward toward the disks. During operation, coolant flows though the housing across the disks and windows while electron beams passes through the window and the disks. The window temperature increases,... Los Alamos National Security Llc

Swarm immunization with 54 envelopes from ch505

In certain aspects the invention provides HIV-1 immunogens, including envelopes (CH505) and selections therefrom, and methods for swami immunizations using combinations of HIV-1 envelopes.... Los Alamos National Security Llc

Composition and method comprising overcoated quantum dots

Disclosed herein are embodiments of a coated type-I quantum dot comprising a core and a shell, and a silica layer, and a method for making the quantum dot. The quantum dot may be a thick-shelled quantum dot. Also disclosed are embodiments of a composition comprising one or more coated quantum... Los Alamos National Security Llc

Compositions comprising ch848 envelopes and uses thereof

In certain aspects the invention provides immonogenic compositions comprising CH848 HIV-1 envelopes and their use in methods to induce immune responses in subjects, e.g., human subjects.... Los Alamos National Security Llc

Optimized thionin protects plants against bacterial infections

Two small proteins with anti-bacterial activity are generated and called optimized thionin and optimized pro-thionin. Optimized pro-thionin contains a signal sequence for intracellular trafficking of the protein and is cleaved off to yield optimized thionin. Genetically altered plants and their progeny expressing a polynucleotide encoding optimized pro-thionin or optimized thionin... Los Alamos National Security Llc

Acoustic concentration of particles in fluid flow

An apparatus for acoustic concentration of particles in a fluid flow includes a substantially acoustically transparent membrane and a vibration generator that define a fluid flow path therebetween. The fluid flow path is in fluid communication with a fluid source and a fluid outlet and the vibration generator is disposed... Los Alamos National Security Llc

Bio-assessment device and making the device

Disclosed herein are embodiments of a device that can be used to mimic the biochemical and physiological actions of a lung organ. Also disclosed herein are embodiments of components that are included in the device as well as methods of making and using the device. Further disclosed are platform device... Los Alamos National Security Llc

Immunoassays for the differentiation of bacterial pathogens in human serum

Systems for and methods of capturing, detecting, quantifying, and characterizing target moieties that are characterized by having a lipophilic portion of sufficient size and chemical composition whereby the target moiety inserts (or partitions) into a lipid assembly are described. Methods of diagnosing a subject as having a bacterial infection by... Los Alamos National Security Llc

Magnetically controlled valve and pump devices and methods of using the same

Disclosed herein are embodiments of magnetically controlled valve and pump systems that can be used to control and facilitate fluid flow in fluidic devices. Various types of magnetically controlled valves and pumps are described as well as methods of magnetically-controlling such valves and pumps.... Los Alamos National Security Llc

Microfluidic aspirator and methods of making and using the same

Disclosed herein are devices that include a top chamber including at least one port, a bottom chamber including at least one inlet and at least one outlet, wherein the opening of the at least one inlet is smaller than the opening of the at least one outlet, and a membrane... Los Alamos National Security Llc

Devices for fluid management

Disclosed herein are embodiments of devices for managing fluid transport. In particular disclosed embodiments, the devices are used to manage fluid transport in reactor systems, such as bio-assessment systems, chemical synthesis reactors, and the like. The devices disclosed herein include fluid management devices, reservoir assemblies, valving systems, pumps, and combinations... Los Alamos National Security Llc

Compositions comprising ch505 envelopes, and trimers

In certain aspects the invention provides a selection of HIV-1 envelopes suitable for use as immunogens, and methods of using these immunogens to induce neutralizing antibodies. In certain embodiments, the immunogens are designed to trimerize. In other embodiments, the immunogens comprise an immune modulating component.... Los Alamos National Security Llc

Multi-organ media compositions and methods of their use

Disclosed herein are media for culture of cells, tissues, and/or organs. The media formulations disclosed herein can be used to support growth, viability, and/or function of one or more than one cell type, tissue, or organ. In some embodiments, one or more cell types, tissues, organ devices, and/or organs are... Los Alamos National Security Llc

Antiviral vaccines with improved cellular immunogenicity

The invention provides compositions, methods, and kits for the treatment or prevention of viral infections. The polyvalent (e.g., 2-valent) vaccines described herein incorporate computationally-optimized viral polypeptides that can increase the diversity or breadth and depth of cellular immune response in vaccinated subjects.... Los Alamos National Security Llc

Context-dependent piano music transcription with convolutional sparse coding

The present disclosure presents a novel approach to automatic transcription of piano music in a context-dependent setting. Embodiments described herein may employ an efficient algorithm for convolutional sparse coding to approximate a music waveform as a summation of piano note waveforms convolved with associated temporal activations. The piano note waveforms... Los Alamos National Security Llc

Nucleic acid detection detecting influenza

The invention provides a rapid, sensitive and specific nucleic acid detection system which utilizes isothermal nucleic acid amplification in combination with a lateral flow chromatographic device, or DNA dipstick, for DNA-hybridization detection. The system of the invention requires no complex instrumentation or electronic hardware, and provides a low cost nucleic... Los Alamos National Security Llc

Luminescent solar concentrators comprising semiconductor nanocrystals

Disclosed herein are embodiments of a composition comprising a polymer or sol-gel matrix and one or more nanocrystals. The composition is useful for making various products, including a luminescent solar concentrator. The nanocrystals are dispersed in the polymer or sol-gel matrix to reduce or substantially prevent nanocrystal-to-nanocrystal energy transfer and... Los Alamos National Security Llc

Classification of multispectral or hyperspectral satellite imagery using clustering of sparse approximations on sparse representations in learned dictionaries obtained using efficient convolutional sparse coding

An approach for land cover classification, seasonal and yearly change detection and monitoring, and identification of changes in man-made features may use a clustering of sparse approximations (CoSA) on sparse representations in learned dictionaries. The learned dictionaries may be derived using efficient convolutional sparse coding to build multispectral or hyperspectral,... Los Alamos National Security Llc

Actinium-225 compositions of matter and methods of their use

The present invention is directed to improved methods for generating compositions comprising actinium-225.... Los Alamos National Security Llc

Multi-phasic explosive fracturing system

Disclosed herein are embodiments of precursor components (or compositions thereof) that can be combined with one or more additional components (or compositions thereof) to form an explosive composition. The disclosed precursor components (or compositions thereof) can be handled and transported safely to a particular location where they can be mixed... Los Alamos National Security Llc

Poly(phenylene)-based anion exchange polymers and methods thereof

The present invention relates to anionic exchange polymers including a poly(phenylene) structure. The structure can include any useful cationic moiety. Methods and uses of such structures and polymers are also described herein. In one instance, such polymers are employed to form a solid membrane.... Los Alamos National Security Llc

Path scanning for the detection of anomalous subgraphs and use of dns requests and host agents for anomaly/change detection and network situational awareness

A system, apparatus, computer-readable medium, and computer-implemented method are provided for detecting anomalous behavior in a network. Historical parameters of the network are determined in order to determine normal activity levels. A plurality of paths in the network are enumerated as part of a graph representing the network, where each... Los Alamos National Security Llc

Miniaturized lateral flow device for rapid and sensitive detection of proteins or nucleic acids

The invention provides miniaturized lateral flow chromatographic and lateral flow chromatographic microarray devices (LFM). The miniaturization of lateral flow nucleic acid detection achieved by the present invention offers reduced reagent use, femtomole sensitivity, excellent linear dynamic range, and rapid detection. Moreover, the small feature sizes of capture oligonucleotides renders the... Los Alamos National Security Llc

Biomarkers for the pre-symptomatic diagnosis of huanglongbing (hlb) in citrus and use thereof

The identification of genes upregulated following infection of citrus trees by Liberibacter, the causative agent of huanglongbing (HLB), is described. Methods for detecting pre-symptomatic HLB in citrus trees by detecting expression of one or more genes overexpressed following infection by Liberibacter is also described.... Los Alamos National Security Llc

System for fracturing an underground geologic formation

An explosive system for fracturing an underground geologic formation adjacent to a wellbore can comprise a plurality of explosive units comprising an explosive material contained within the casing, and detonation control modules electrically coupled to the plurality of explosive units and configured to cause a power pulse to be transmitted... Los Alamos National Security Llc

Plant glutamine phenylpyruvate transaminase gene and transgenic plants carrying same

The invention relates to transgenic plants exhibiting enhanced growth rates, seed and fruit yields, and overall biomass yields, as well as methods for generating growth-enhanced transgenic plants. In one embodiment, transgenic plants engineered to over-express glutamine phenylpyruvate transaminase (GPT) are provided.... Los Alamos National Security Llc

Mosaic hiv-1 sequences and uses thereof

The invention is directed to mosaic HIV 1 genes designed to induce T-cell responses.... Los Alamos National Security Llc

Transgenic cells with increased plastoquinone levels and methods of use

Disclosed herein are transgenic cells expressing a heterologous nucleic acid encoding a prephenate dehydrogenase (PDH) protein, a heterologous nucleic acid encoding a homogentisate solanesyl transferase (HST) protein, a heterologous nucleic acid encoding a deoxyxylulose phosphate synthase (DXS) protein, or a combination of two or more thereof. In particular examples, the... Los Alamos National Security Llc

04/20/17 / #20170108471

High-temperature, high pressure acoustic resonance cell

A compact, rugged and portable measurement cell design for the determination of sound speed in fluids at temperatures up to 250° C. and pressures up to 3,000 psi is described. Swept Frequency Acoustic Interferometry measurement for liquid sound speed determinations in liquids up to 250° C. is of both fundamental... Los Alamos National Security Llc

04/06/17 / #20170098829

Non-precious fuel cell catalysts comprising polyaniline

A method of producing a catalyst suitable for use in a membrane electrode assembly involves providing a mixture comprising a polyaniline precursor and a catalyst support; adding to said mixture an oxidant and a compound comprising a transition metal; agitating said mixture sufficiently to result in polyaniline polymerization; drying the... Los Alamos National Security Llc

03/30/17 / #20170088571

Polydentate ligands and their complexes for molecular catalysis

Embodiments of the present disclosure relate generally to novel achiral and chiral sulfur-, nitrogen- and phosphorus-containing ligands, designated as NNS-type, P(O)NS-type, PNS-type, SNNS-type, SNNP(O)-type, or SNNP-type polydentate ligands and transition metal complexes of these ligands, including iridium complexes having PNS-type and NNS-type ligands. The catalysts derived from these ligands and... Los Alamos National Security Llc

03/23/17 / #20170080082

Swarm immunization with envelopes from ch505

In certain aspects the invention provides HIV-1 immunogens, including envelopes (CH505) and selections therefrom, and methods for swarm immunizations using combinations of HIV-1 envelopes.... Los Alamos National Security Llc

03/02/17 / #20170059555

Sample platform and methods of use

Disclosed herein is a platform for holding a biological sample with a movable radiation source that can be used to expose the sample to controlled dosages of radiation in a targeted manner. In some embodiments, the platform includes a support structure and a cartridge for holding a sample. In some... Los Alamos National Security Llc

03/02/17 / #20170063695

Full flow retrieval optimized packet capture

A packet capture system may copy packets from an interface to a bucket. When the bucket is full of packets, a new bucket for incoming packets may be started, and the full bucket may be indexed. During the indexing, each packet may be sorted in the bucket by flow, and... Los Alamos National Security Llc

03/02/17 / #20170063695

Full flow retrieval optimized packet capture

A packet capture system may copy packets from an interface to a bucket. When the bucket is full of packets, a new bucket for incoming packets may be started, and the full bucket may be indexed. During the indexing, each packet may be sorted in the bucket by flow, and... Los Alamos National Security Llc

02/23/17 / #20170051301

Transgenic plants with enhanced growth characteristics

The invention relates to transgenic plants exhibiting dramatically enhanced growth rates, greater seed and fruit/pod yields, earlier and more productive flowering, more efficient nitrogen utilization, increased tolerance to high salt conditions, and increased biomass yields. In one embodiment, transgenic plants engineered to over-express both glutamine phenylpyruvate transaminase (GPT) and glutamine... Los Alamos National Security Llc

02/02/17 / #20170029351

Synthesis of fuels and feedstocks

Disclosed herein are embodiments of a method for making fuels and feedstocks from readily available alcohol starting materials. In some embodiments, the method concerns converting alcohols to carbonyl-containing compounds and then condensing such carbonyl-containing compounds together to form oligomerized species. These oligomerized species can then be reduced using by-products from... Los Alamos National Security Llc

02/02/17 / #20170029812

Genetically engineered polymer libraries and methods of using them

Disclosed herein are methods of identifying polymers having particular biological or physical characteristics from in vivo generated libraries of polymers. Methods of generating in vivo polymer libraries are also described. Polymers identified using the methods of the invention are also described.... Los Alamos National Security Llc

02/02/17 / #20170033385

Polyol-based compositions comprising cationic group-functionalized polyphenylene polymers

Disclosed herein are embodiments of compositions comprising polyols and cationic group-functionalized polyphenylene polymers suitable for use in electrochemical systems. The disclosed composition exhibit improved dispersion properties and further provide anion exchange polymer membranes exhibited improved chemical and mechanical properties. Also disclosed herein are methods of making and using the disclosed... Los Alamos National Security Llc

01/26/17 / #20170022122

Conversion of oligomeric starch, cellulose, hydrolysates or sugars to hydrocarbons

Embodiments of the present invention are directed to the conversion of a source material (e.g., a depolymerized oligosaccharide mixture, a monomeric sugar, a hydrolysate, or a mixture of monomeric sugars) to intermediate molecules containing 7 to 26 contiguous carbon atoms. These intermediates may also be converted to saturated hydrocarbons. Such... Los Alamos National Security Llc

01/19/17 / #20170014503

Mper-liposome conjugates and uses thereof

The present invention relates to peptides and compositions suitable for use in inducing anti-HIV-1 antibodies. The compositions comprise HIV-1 gp41 membrane proximal external region (MPER) peptide-liposome conjugates for induction of broadly reactive anti-HIV-1 antibodies. The invention also relates to methods of inducing neutralizing anti-HIV-1 antibodies using such compositions.... Los Alamos National Security Llc

01/19/17 / #20170016703

Detonation control

Detonation control modules and detonation control circuits are provided herein. A trigger input signal can cause a detonation control module to trigger a detonator. A detonation control module can include a timing circuit, a light-producing diode such as a laser diode, an optically triggered diode, and a high-voltage capacitor. The... Los Alamos National Security Llc

01/19/17 / #20170018673

Uranium oxide solar cells

Solar cells including thin film depleted uranium oxide (DUO) may be produced using an ion beam assisted deposition (IBAD) process, for example. p-type DUO film and n-type DUO film may form a p/n junction. The photovoltaic (PV) structure may be completed by evaporating a metal electrode on top of one... Los Alamos National Security Llc








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