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Massachusetts Eye And Ear Infirmary patents


Recent patent applications related to Massachusetts Eye And Ear Infirmary. Massachusetts Eye And Ear Infirmary is listed as an Agent/Assignee. Note: Massachusetts Eye And Ear Infirmary may have other listings under different names/spellings. We're not affiliated with Massachusetts Eye And Ear Infirmary, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "M" | Massachusetts Eye And Ear Infirmary-related inventors


 new patent  Cyp450 lipid metabolites reduce inflammation and angiogenesis

Methods for reducing angiogenesis, inflammation, and vascular permeability in a subject by administering an epoxymetabolite of Docosahexaenoic acid (DHA) and Eicosapentaenoic acid (EPA), e.g., as listed in Table A, e.g., one or both of 17,18-epoxyeicosatetraenoic acid (EEQ) and 19,20-epoxydocosapentaenoic acid (EDP), e.g., for the treatment of conditions associated with inflammation... Massachusetts Eye And Ear Infirmary

Prosthetic devices for semicircular canal defects

This disclosure features elongated prosthetic devices that can be used to repair, e.g., resurface or occlude, a defect of a semicircular canal, e.g., a superior semicircular canal dehiscence, as wellmethods of making and using these devices. For example, the devices can be made using three-dimensional (3D) printing.... Massachusetts Eye And Ear Infirmary

Methods of delivering an agent to the eye

Methods of delivering agents to structures within the eye are provided.... Massachusetts Eye And Ear Infirmary

Artificial tympanic membrane devices and uses

This disclosure features artificial tympanic membrane graft devices and two-component bilayer graft devices that include a scaffold having a plurality of ribs made of a first material and a plurality of spaces between the ribs filled or made with the first material, a different, second material, a combination of the... Massachusetts Eye And Ear Infirmary

Gene augmentation therapies for inherited retinal degeneration caused by mutations in the prpf31 gene

The present invention relates to methods and compositions for gene therapy of retinitis pigmentosa related to mutations in pre-mRNA processing factor 31 (PRPF31).... Massachusetts Eye And Ear Infirmary

Methods for treating ocular inflammatory disorders

Provided are methods for treating ocular inflammatory disorders, including macular edema, using an AMP kinase activator, e.g., 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAR). The method reduces inflammation, thereby minimizing the loss of vision or visual function associated with these ocular disorders.... Massachusetts Eye And Ear Infirmary

Methods and compositions for preserving the viability of photoreceptor cells

Provided are methods and compositions for maintaining the viability of photoreceptor cells following retinal detachment. The viability of photoreceptor cells can be preserved by administering an apoptosis inhibitor to a mammal having an eye with retinal detachment. The apoptosis inhibitor maintains the viability of the photoreceptor cells until such time... Massachusetts Eye And Ear Infirmary

Method and process for quantitative evaluation of pharmacokinetics, therapeutic effects and safety of delivery of drug compounds to the inner ear for treatment of auditory disease

The present disclosure provides compositions and methods for treating an auditory disease in a subject in need thereof comprising administering an effective amount of a gel-based precursor that includes an inner ear-specific therapeutic compound directly into the cochlea of the subject.... Massachusetts Eye And Ear Infirmary

Methotrexate for proliferative vitreoretinopathy

The use of methotrexate, e.g., repeated dosing or sustained-release formulations of methotrexate, for treating or reducing risk of proliferative vitreoretinopathy (PVR) or epiretinal membranes (ERM), e.g., after surgical vitrectomy to treat retinal detachment.... Massachusetts Eye And Ear Infirmary

Treatment of ocular disorders

The invention includes a method of treating an intraocular disorder in a mammal, the method comprising administering to the mammal a Very Late Antigen-4 (VLA-4) antagonist for the treatment of selected ocular disorders.... Massachusetts Eye And Ear Infirmary

Treatment of rhinosinusitis with p-glycoprotein inhibitors

Provided herein are, inter alia, methods for treating rhinosinusitis with P-glycoprotein inhibitors. A subject having rhinosinusitis is identified and then treated by administration to the subject an effective amount of a P-gp inhibitor. The subject having rhinosinusitis can be identified by one of skill in the art based on known... Massachusetts Eye And Ear Infirmary

Efficient delivery of therapeutic molecules in vitro and in vivo

Compositions are described for direct protein delivery into multiple cell types in the mammalian inner ear. The compositions are used to deliver protein(s) (such as gene editing factors) editing of genetic mutations associated with deafness or associated disorders thereof. The delivery of genome editing proteins for gene editing and correction... Massachusetts Eye And Ear Infirmary

Efficient delivery of therapeutic molecules in vitro and in vivo

A chimeric molecule of one or more proteins or peptides fused, complexed or linked to one or more anionic molecules. Efficient in vitro and in vivo delivery is attained by encapsulating these molecules in cationic lipids or cationic liposomes. Methods of treatment include the intracellular delivery of these molecules to... Massachusetts Eye And Ear Infirmary

Efficient delivery of therapeutic molecules to cells of the inner ear

Compositions and provided to induce cells of the inner ear to renter the cell cycle and to proliferate. In particular, hair cells are induced to proliferate by administration of a composition which activates the Myc and Notch. Supporting cells are induced to transdifferentiate to hair cells by inhibition of Myc... Massachusetts Eye And Ear Infirmary

Increasing atoh1 life to drive sensorineural hair cell differentiantion

The present disclosure provides compositions and methods for treating subjects at risk for or with sensorineural hearing loss by modulating the rate of Atoh1 protein degradation to increase levels of Atoh1 protein.... Massachusetts Eye And Ear Infirmary

Methods of predicting ancestral virus sequences and uses thereof

Methods are described for predicting ancestral sequences for viruses or portions thereof. Also described are predicted ancestral sequences for adeno-associated virus (AAV) capsid polypeptides. The disclosure also provides methods of gene transfer and methods of vaccinating subjects by administering a target antigen operably linked to the AAV capsid polypeptides.... Massachusetts Eye And Ear Infirmary

Method for efficient delivery of therapeutic molecules in vitro and in vivo

Compositions are described for direct protein delivery into multiple cell types in the mammalian inner ear. The compositions are used to deliver protein(s) (such as gene editing factors) editing of genetic mutations associated with deafness or associated disorders thereof. The delivery of genome editing proteins for gene editing and correction... Massachusetts Eye And Ear Infirmary

Drug-eluting stapes prosthesis

A medical implant device includes a prosthesis adapted to replace at least a portion of a bone. The prosthesis includes a drug-eluting polymer adapted to deliver a drug to at least a portion of an area surrounding the prosthesis.... Massachusetts Eye And Ear Infirmary

Methotrexate for proliferative vitreoretinopathy

The use of methotrexate, e.g., repeated dosing or sustained-release formulations of methotrexate, for treating or reducing risk of proliferative vitreoretinopathy (PVR) or epiretinal membranes (ERM), e.g., after surgical vitrectomy to treat retinal detachment.... Massachusetts Eye And Ear Infirmary

Methods and compositions for preserving photoreceptor and retinal pigment epithelial cells

Provided are methods and compositions for maintaining the viability of photoreceptor cells and/or retinal pigment epithelial cells in a subject with an ocular disorder including, for example, age-related macular degeneration (AMD) (e.g., dry or neovascular AMD), retinitis pigmentosa (RP), or a retinal detachment. The viability of the photoreceptor cells and/or... Massachusetts Eye And Ear Infirmary

Piezoelectric sensors for hearing aids

This disclosure describes techniques and systems to aid hearing of subjects using implantable systems, e.g., fully implantable systems, which include a piezoelectric sensor to generate electric signals from detected acoustic vibrations of middle ear ossicles. The systems can include, for example, middle ear implants and cochlear implants.... Massachusetts Eye And Ear Infirmary

Methods and compositions for preserving the viability of photoreceptor cells

Provided are methods and compositions for maintaining the viability of photoreceptor cells following retinal detachment. The viability of photoreceptor cells can be preserved by administering a neuroprotective agent, for example, a substance capable of suppressing endogenous MCP-1, a MCP-1 antagonist, a substance capable of suppressing endogenous TNF-alpha, a TNF-alpha antagonist,... Massachusetts Eye And Ear Infirmary

Inflammatory eye disorders

Provided herein are methods of evaluating efficacy of a treatment in a subject having eye inflammation (e.g., a subject having dry eye syndrome) and selecting a subject for participation in a clinical study. Also provided are methods of treating a subject having eye inflammation (e.g., a subject having dry eye... Massachusetts Eye And Ear Infirmary

Methods of predicting ancestral virus sequences and uses thereof

Methods are described for predicting ancestral sequences for viruses or portions thereof. Also described are predicted ancestral sequences for adeno-associated virus (AAV) capsid polypeptides. The disclosure also provides methods of gene transfer and methods of vaccinating subjects by administering a target antigen operably linked to the AAV capsid polypeptides.... Massachusetts Eye And Ear Infirmary

Methods for cross-linking corneal collagen with verteporfin for the treatment of disorders of the eye

Described are compositions and methods of using verteporfin-based photodynamic therapy (PDT) to increase the biomechanical strength of the cornea. More particularly, described herein are compositions and methods for cross-linking collagen in corneal tissue which are useful in the treatment of corneal ectatic disorders.... Massachusetts Eye And Ear Infirmary

Methods and compositions for treating conditions of the eye

Provided are methods and compositions for treating ocular conditions characterized by the presence of unwanted choroidal neovasculature, for example neovascular age-related macular degeneration. The selectivity and sensitivity of, for example, a photodynamic therapy (PDT)based approach can be enhanced by combining the PDT with an anti-FasL factor, for example, an anti-FasL... Massachusetts Eye And Ear Infirmary

Methods of treating glaucoma using amp-activated protein kinase (ampk) activators

Methods of reducing intraocular pressure in a mammal using AMPK activators, e.g., for treating glaucoma.... Massachusetts Eye And Ear Infirmary








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