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Massachusetts Institute Of Technology patents


Recent patent applications related to Massachusetts Institute Of Technology. Massachusetts Institute Of Technology is listed as an Agent/Assignee. Note: Massachusetts Institute Of Technology may have other listings under different names/spellings. We're not affiliated with Massachusetts Institute Of Technology, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "M" | Massachusetts Institute Of Technology-related inventors


Methods and shape-changing food

An edible structure may comprise a gelatin film and fiber strips. The gelatin film may have a higher density of gelatin in a first layer of the film than in a second layer of the film. The fiber strips may be attached to the first layer, and may have an... Massachusetts Institute Of Technology

Reaction circuit design in microfluidic circuits

The microfluidic devices and systems disclosed herein reduce sample loss and help decrease sample processing bottlenecks for applications such as next generation sequencing (NGS). The microfluidic devices include a plurality of reaction modules. Each reaction module may comprise one or more reaction circuits. Each reaction circuit may comprise a single... Massachusetts Institute Of Technology

Antibodies that bind zika virus envelope protein and uses thereof

Isolated monoclonal antibodies which bind to Zika virus envelope protein and related antibody-based compositions and molecules are disclosed. Also disclosed are therapeutic and diagnostic methods for using the antibodies.... Massachusetts Institute Of Technology

Method for rna-guided endonuclease-based dna assembly

The invention provides a novel approach to facilitate assembly of DNA molecules. This approach utilizes RNA-guided endonucleases, capable of targeting any DNA sequence, which cleave DNA and generate DNA fragments characterized by single stranded overhangs. After annealing of complementary overhangs, DNA fragments are covalently connected, generating a single DNA molecule.... Massachusetts Institute Of Technology

Methods and imaging using optical cavity

In illustrative implementations, an imaging system may comprise a lens, an optical cavity and a time-of-flight camera. The imaging system may capture an image of a scene. The image may be formed by light that is from the scene and that passes through the optical cavity and the lens. In... Massachusetts Institute Of Technology

Chemical and physical sensing with a reader and rfid tags

A method of detecting a stimulus can include detecting an output from a radio frequency identification tag including a sensor. A smartphone-based sensing strategy can use chemiresponsive nanomaterials integrated into the circuitry of commercial Near Field Communication tags to achieve non-line-of-sight, portable, and inexpensive detection and discrimination of gas phase... Massachusetts Institute Of Technology

Voltage-controlled resistive devices

... Massachusetts Institute Of Technology

Inhibitors of histone deacetylase

or a pharmaceutically acceptable salt, hydrate, solvate, or prodrug thereof, wherein U, J, V, X, R2a, R2b, R2c, R5 and t are as described herein. The present invention relates generally to inhibitors of histone deacetylase and to methods of making and using them. These compounds are useful for promoting cognitive... Massachusetts Institute Of Technology

Tumor and microenvironment gene expression, compositions of matter and methods of use thereof

This invention relates generally to compositions and methods for identifying genes and gene networks that respond to, modulate, control or otherwise influence tumors and tissues, including cells and cell types of the tumors and tissues, and malignant, microenvironmental, or immunologic states of the tumor cells and tissues. The invention also... Massachusetts Institute Of Technology

Stable nanocrystalline ordering alloy systems and methods of identifying same

Provided in one embodiment is a method of identifying a stable phase of an ordering binary alloy system comprising a solute element and a solvent element, the method comprising: determining at least three thermodynamic parameters associated with grain boundary segregation, phase separation, and intermetallic compound formation of the ordering binary... Massachusetts Institute Of Technology

Cryogenic electronic packages and methods for fabricating cryogenic electronic packages

A cryogenic electronic package includes a first superconducting multi-chip module (SMCM), a superconducting interposer, a second SMCM and a superconducting semiconductor structure. The interposer is disposed over and coupled to the first SMCM, the second SMCM is disposed over and coupled to the interposer, and the superconducting semiconductor structure is... Massachusetts Institute Of Technology

Cryogenic electronic packages and assemblies

A cryogenic electronic package includes a circuitized substrate, an interposer, a superconducting multichip module (SMCM) and at least one superconducting semiconductor structure. The at least one superconducting semiconductor structure is disposed over and coupled to the SMCM, and the interposer is disposed between the SMCM and the substrate. The SMCM... Massachusetts Institute Of Technology

Coupled split path power conversion architecture

Described herein are power conversion systems and related techniques which utilize a coupled split path (CSP) circuit architecture. The CSP structure combines switches, capacitors and magnetic elements in such a way that power is processed in multiple coupled split paths in a variety of voltage domains. These techniques are well... Massachusetts Institute Of Technology

Materials for use with aqueous redox flow batteries and related methods and systems

Described herein are redox flow batteries comprising a first aqueous electrolyte comprising a first type of redox active material and a second aqueous electrolyte comprising a second type of redox active material. The first type of redox active material may comprise one or more types of quinoxalines, or salts thereof.... Massachusetts Institute Of Technology

Systems and methods for dual-mode imaging using optical coherence tomography and fluorescence imaging

Systems and methods are provided to obtain optical coherence tomography data and fluorescence imaging data from an object. The systems and methods use a single light source to illuminate and excite fluorescence in the object and a common optical path including an optical fiber to provide illumination and excitation light... Massachusetts Institute Of Technology

Hydrogel encapsulated cells and anti-inflammatory drugs

A composition containing biocompatible hydrogel encapsulating mammalian cells and anti-inflammatory drugs is disclosed. The encapsulated cells have reduced fibrotic overgrowth after implantation in a subject. The compositions contain a biocompatible hydrogel having encapsulated therein mammalian cells and anti-inflammatory drugs or polymeric particles loaded with anti-inflammatory drugs. The anti-inflammatory drugs are... Massachusetts Institute Of Technology

Segregation resistant perovskite oxides with surface modification

A method and a composition to stabilize the surface cation chemistry of the perovskite or related oxides, and thus, to minimize or completely avoid the detrimental segregation and phase separation of dopant cations at the surface can include modifying the surface with more oxidizable metal cations and/or more oxidizable metal... Massachusetts Institute Of Technology

Bottlebrush copolymers and uses thereof

Materials (e.g., particles, hydrogels) that provide extended release of one or more therapeutic agents are useful platforms for drug delivery. In part, the present invention relates to new triblock (ABC) bottlebrush copolymers which can be used in the formulation of particles and hydrogels for the extended release of therapeutic agents.... Massachusetts Institute Of Technology

Method and reducing sensor power dissipation

A sensor produces the sensor data for a sensor data consumer. A facility receives a sensor profile of the sensor indicating a relationship between a sensor parameter operating range and a deviation of the sensor data as a result of scaling one or more sensor parameters. The facility receives a... Massachusetts Institute Of Technology

Variable thermal resistance

Electrical and electromechanical devices often require maintaining a specific temperature, or a narrow range or temperatures, during operation. An assembly regulates the temperature of a device by providing a variable thermal resistance between the device and a heatsink. The device can be mounted to a base having a high thermal... Massachusetts Institute Of Technology

Devices for refractive field visualization

An apparatus according to an embodiment of the present invention enables measurement and visualization of a refractive field such as a fluid. An embodiment device obtains video captured by a video camera with an imaging plane. Representations of apparent motions in the video are correlated to determine actual motions of... Massachusetts Institute Of Technology

Use of chelators of divalent cations to promote nerve regeneration

Disclosed herein are methods to promote axonal outgrowth of a neuron comprising, contacting the neuron with an effective amount of a chelating agent, to thereby promote axonal outgrowth in the neuron. Also disclosed are methods of treating a subject for a CNS lesion, comprising, administering to the subject a therapeutically... Massachusetts Institute Of Technology

Controlled-orientation films and nanocomposites including nanotubes or other nanostructures

Generally, the present invention provides methods for the production of materials comprising a plurality of nanostructures such as nanotubes (e.g., carbon nanotubes) and related articles. The plurality of nanostructures may be provided such that their long axes are substantially aligned and, in some cases, continuous from end to end of... Massachusetts Institute Of Technology

High-performance supercapacitors based on metal nanowire yarns

An energy-storage device is formed from a first and a second yarn, each yarn including a plurality of nanowires including aluminum and/or a transition metal. An anode pad is in contact with the first yarn and a cathode pad is in contact with the second yarn. Alternatively, first and second... Massachusetts Institute Of Technology

Stacked patch antenna array with castellated substrate

Described is a printed circuit antenna array including at least one castellated substrate. Also described is a stacked patch antenna array having at least one castellated substrate.... Massachusetts Institute Of Technology

Apparatus and determining an eye prescription

Eye prescriptions may be determined by providing a simple, easy to use, portable device with a specially configured targeting light source that aligns the eye, mitigates accommodation, and provides accurate results. Unlike stationary, closed view autorefractors, this device typically is portable, self-usable, relatively inexpensive, enabling more widespread use across the... Massachusetts Institute Of Technology

Cardiovascular assist system that quantifies heart function and faciltates heart recovery

The systems, devices, and methods presented herein use a heart pump to obtain measurements of cardiovascular function. The heart pumps described herein can operate in parallel with and unload the heart. The system can quantify the functioning of the native heart by measuring certain parameters/signals such as pressure or motor... Massachusetts Institute Of Technology

Methods and compositions for treating alzheimer's disease and other memory-associated disorders and conditions

The invention, in part, relates to the use of optogenetic methods to increase dendritic spine density on DG memory engram cells in treatment methods for memory-impairment-associated diseases and conditions.... Massachusetts Institute Of Technology

Amphiphilic nanoparticles for delivery of crispr based therapy

Disclosed are copolymer micelles for simultaneous delivery of Cas9 mRNA and guide RNA for Cas9 CRISPR gene editing. Also disclosed are copolymer micelles for simultaneous delivery of a therapeutic or diagnostic nucleic acid and a cross-linking or alkylating anticancer agent.... Massachusetts Institute Of Technology

Antibacterial coatings that inhibit biofilm formation on implants

Orthopedic and dental implants coated with an antibacterial coating and methods of making and using, are described herein. The implant can be coated with a hydrophobic, polycationic antibacterial polymer. The polymer can be covalently or non-covalently associated with the surface; however, in particular embodiments, the polymer is non-covalently associated with... Massachusetts Institute Of Technology

Systems, devices, and methods for microfluidics using modular blocks

The present disclosure is directed to the creation and/or manipulation of microfluidic systems and methods that can be formed in pre-existing modular blocks. Microfluidic paths can be formed in one or more blocks, and when multiple blocks are used, the blocks can be used together to form a path across... Massachusetts Institute Of Technology

Automatic process control of additive manufacturing device

Automatic process control of additive manufacturing. The system includes an additive manufacturing device for making an object and a local network computer controlling the device. At least one camera is provided with a view of a manufacturing volume of the device to generate network accessible images of the object. The... Massachusetts Institute Of Technology

Constructs for continuous monitoring of live cells

Embodiments disclosed herein provide nucleic acid constructs and methods of use thereof that induce a live cell to give off sub-samples of the cell's cytosolic content. The term “cell” as used herein may be any cell type. In certain example embodiments, the cells are mammalian cells. The sampling can be... Massachusetts Institute Of Technology

Encoding of dna vector identity via iterative hybridization detection of a barcode transcript

Embodiments disclosed herein are directed to a new genetic perturbation and screening method that combines advantages of pooled perturbation with imaging assays for complex phenotypes. Specifically, the method may be used to screen pooled genomic perturbations to identify phenotypes and to identify perturbed genes at the single-cell level using optical... Massachusetts Institute Of Technology

Microbial engineering for the production of chemical and pharmaceutical products from the isoprenoid pathway

The invention relates to recombinant expression of a taxadiene synthase enzyme and a geranylgeranyl diphosphate synthase (GGPPS) enzyme in cells and the production of terpenoids.... Massachusetts Institute Of Technology

03/22/18 / #20180080927

Systems including janus droplets

Embodiments described herein may be useful in the detection of analytes. The systems and methods may allow for a relatively simple and rapid way for detecting analytes such as chemical and/or biological analytes and may be useful in numerous applications including sensing, food manufacturing, medical diagnostics, performance materials, dynamic lenses,... Massachusetts Institute Of Technology

03/15/18 / #20180071215

Core-shell particles for controlled release

Compositions, methods, and systems for controlling crystallization of an agent are generally described. In some embodiments, an agent is crystallized in the presence of polymer matrices, such as polymer particles. The polymer matrix may influence at least a portion of the crystallization process and/or the resulting composition. In some such... Massachusetts Institute Of Technology

03/15/18 / #20180071738

Massively parallel on-chip coalescence of microemulsions

Embodiments disclosed herein are directed to microfluidic devices that allow for scalable on-chip screening of combinatorial libraries and methods of use thereof. Droplets comprising individual molecular species to be screened are loaded onto the microfluidic device. The droplets are labeled by methods known in the art, including but not limited... Massachusetts Institute Of Technology

03/15/18 / #20180072327

Systems and methods for using an attention buffer to improve resource allocation management

Systems and methods for assessing resource allocation are provided. In some exemplary embodiments, the system uses an attention buffer to classify glances by a person and/or automated system, the buffer determining the impact the glances have on the person and/or automated system's situation awareness level. The attention buffer calculates on... Massachusetts Institute Of Technology

03/15/18 / #20180072895

Apparatus and methods employing liquid-impregnated surfaces

In certain embodiments, the invention is directed to apparatus comprising a liquid-impregnated surface, said surface comprising an impregnating liquid and a matrix of solid features spaced sufficiently close to stably contain the impregnating liquid therebetween or therewithin, and methods thereof. In some embodiments, one or both of the following holds:... Massachusetts Institute Of Technology

03/15/18 / #20180073031

Transcriptional sensor for bile acids in bacteroides thetaiotaomicron

The present disclosure relates, in some aspects, to bile acid sensors.... Massachusetts Institute Of Technology

03/15/18 / #20180074383

Electroactive polymer membrane-based active lens assemblies

Active lens assemblies based on a deformable lens adhered to an electroactive polymer (EAP) membrane based actuator, active lens systems comprising such active lenses, and methods of actuating a deformable lens are described. The active lenses can provide controllable optical power, withstand constant periods of actuation, have low power consumption,... Massachusetts Institute Of Technology

03/15/18 / #20180074457

Near-to-eye and see-through holographic displays

A holographic display is comprised of space-multiplexed elemental modulators, each of which consists of a surface acoustic wave transducer atop an anisotropic waveguide. Each “line” of the overall display consists of a single anisotropic waveguide across the display's length with multiple surface acoustic wave transducers spaced along the waveguide length,... Massachusetts Institute Of Technology

03/15/18 / #20180076003

Method and a porous electrospray emitter

An ionic liquid ion source can include a microfabricated body including a base and a tip. The body can be formed of a porous material compatible with at least one of an ionic liquid or room-temperature molten salt. The body can have a pore size gradient that decreases from the... Massachusetts Institute Of Technology

03/08/18 / #20180066012

Solid phase peptide synthesis processes and associated systems

Systems and processes for performing solid phase peptide synthesis are generally described. Solid phase peptide synthesis is a known process in which amino acid residues are added to peptides that have been immobilized on a solid support. In certain embodiments, the inventive systems and methods can be used to perform... Massachusetts Institute Of Technology

03/08/18 / #20180066242

Crispr-cas altering expression of gene products, structural information and inducible modular cas enzymes

The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are structural information on the Cas protein of the CRISPR-Cas system, use of this information in generating modified components of the CRISPR complex, vectors and vector systems which encode one... Massachusetts Institute Of Technology

03/08/18 / #20180066307

Exosomes and uses thereof

The present invention relates to the isolation and purification of exosomes from biological samples, and to methods for extracting RNA contained therein. The present invention provides methods and uses for the purification of exosomes, as well as compositions comprising same.... Massachusetts Institute Of Technology

03/08/18 / #20180067065

Ethylene sensor

A sensor device can include a transition metal complex capable of interacting with a carbon-carbon multiple bond moiety. The sensor can detect the fruit-ripening hormone ethylene with high sensitivity.... Massachusetts Institute Of Technology

03/08/18 / #20180068062

Methods for identifying novel gene editing elements

Embodiments disclosed herein provide methods for identifying new CRISPR loci and effectors, as well as different CRISPR loci combinations found in various organisms. Class-II CRISPR systems contain single-gene effectors that have been engineered for transformative biological discovery and biomedical applications. Discovery of additional single-gene or multi-component CRISPR effectors may enhance... Massachusetts Institute Of Technology

03/01/18 / #20180056582

Systems, devices, and methods for inkjet-based three-dimensional printing

Devices and methods are described that provide printing of three-dimensional objects using reactive materials such as materials that result in a polyurethane formulation. Three-dimensional printing in accordance with the present disclosure can be performed using an inkjet printer or other systems that deposit or dispense material. A formulation made up... Massachusetts Institute Of Technology

03/01/18 / #20180057443

Mechanochemical synthesis of iptycenes

Methods for mechanochemically synthesizing compositions comprising bridged bicyclic-based compounds such as iptycene-based compounds are generally provided. In some cases, two or more polycyclic aromatic hydrocarbons may be mechanochemically reacted such that the product comprises the bridged bicyclic-based compound. In some embodiments, the product (e.g., the bridged bicyclic compound) may comprise... Massachusetts Institute Of Technology

03/01/18 / #20180057525

Solid phase peptide synthesis processes and associated systems

Systems and processes for performing solid phase peptide synthesis are generally described. Solid phase peptide synthesis is a known process in which amino acid residues are added to peptides that have been immobilized on a solid support. In certain embodiments, the inventive systems and methods can be used to perform... Massachusetts Institute Of Technology

03/01/18 / #20180057810

Functional screening with optimized functional crispr-cas systems

The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are structural information on the Cas protein of the CRISPR-Cas system, use of this information in generating modified components of the CRISPR complex, vectors and vector systems which encode one... Massachusetts Institute Of Technology

03/01/18 / #20180059086

Substrate containing latent vaporization reagents

Methods and reagents are disclosed for improved detection of inorganic oxidizers, such as but not limited to chlorates, perchlorates, permanganates, dichromates, and osmium tetraoxides. In one aspect of the invention, latent acid-generating reagents are employed that are chemically stable at room temperature but undergo an acidic transformation when exposed to... Massachusetts Institute Of Technology

03/01/18 / #20180061063

Methods and devices for measuring object motion using camera images

A method and corresponding apparatus for measuring object motion using camera images may include measuring a global optical flow field of a scene. The scene may include target and reference objects captured in an image sequence. Motion of a camera used to capture the image sequence may be determined relative... Massachusetts Institute Of Technology

03/01/18 / #20180062163

Lithium hydrogen titanate li-h-ti-o material and making the same

A lithium hydrogen titanate Li—H—Ti—O material includes Li, H, Ti, and O elements, wherein a mass percentage of Li is in a range from about 3% to about 12%, a mass percentage of H is in a range from about 0.1% to about 8%, a mass percentage of Ti is... Massachusetts Institute Of Technology

02/22/18 / #20180049636

Dynamic display customizing a controller in a display system

A method, or corresponding dynamic display system, for customizing a controller of a display system includes presenting a visual stimulus to a subject at at least one known location relative to the subject's eye gaze; measuring brain activity of the subject's left and right brain hemispheres in response to the... Massachusetts Institute Of Technology

02/22/18 / #20180049765

Tissue collection needle

A tissue collection needle with a hollow interior provides two opposing tips with beveled edges on facets that drive tissue toward the hollow interior where the tissue can be gathered and severed from surrounding tissue as the needle advances through a biological specimen. The points and bevels are advantageously formed... Massachusetts Institute Of Technology

02/22/18 / #20180050133

Medical devices and implements with liquid-impregnated surfaces

Described herein are medical devices and medical implements with high lubricity to flesh (or biological fluid) and/or inhibited nucleation on its surface. The device has a surface comprising an impregnating liquid and a plurality of micro-scale and/or nano-scale solid features spaced sufficiently close to stably contain the impregnating liquid therebetween.... Massachusetts Institute Of Technology

02/22/18 / #20180051319

High-throughput drug and genetic assays for cellular transformation

A method for detecting oncogenic growth and viability, and/or degree of cellular transformation and/or identifying an agent that inhibits cellular transformation is disclosed. The method including: providing a cellular sample, such as a sample of cells obtained from a subject or a cell line; culturing the cellular sample in low... Massachusetts Institute Of Technology

02/22/18 / #20180053103

Systems and methods for providing visual allocation management

Systems and methods for managing visual allocation are provided herein that use models to determine states based on visual data and, based thereon, output feedback based on the determined states. Visual data is initially obtained by a visual allocation management system. The visual data includes eye image sequences of a... Massachusetts Institute Of Technology

02/22/18 / #20180053934

High-capacity positive electrode active material

This disclosure provides a positive electrode active lithium-excess metal oxide with composition LixMyO2 (0.6≦y≦0.85 and 0≦x+y≦2) for a lithium secondary battery with a high reversible capacity that is insensitive with respect to cation-disorder. The material exhibits a high capacity without the requirement of overcharge during the first cycles.... Massachusetts Institute Of Technology

02/15/18 / #20180042483

Systems and methods for hyperspectral imaging

A method, and corresponding system, can include identifying a plurality of wavelength spectral band components in hyperspectral image data, the spectral band components corresponding to mutually distinct sources of image contrast. An intensity image corresponding to each respective spectral band component can be calculated, followed by combining the respective intensity... Massachusetts Institute Of Technology

02/15/18 / #20180044662

Use and production of chd8+/- transgenic animals with behavioral phenotypes characteristic of autism spectrum disorder

The invention involves inducing a plurality e.g., 3-50 or more mutations (e.g., any whole number between 3 and 50 or more of mutations, with it noted that in some embodiments there can be up to 16 different RNA(s), e.g., sgRNAs each having its own a promoter, in a vector, such... Massachusetts Institute Of Technology

02/15/18 / #20180046585

Timely address space randomization

A method for timely address space randomize includes loading a code region from a program binary to a first location within the address space, detecting, during execution of the program, an output-input call pair from the program and, in response to detecting the output-input call pair from the program: selecting... Massachusetts Institute Of Technology

Patent Packs
02/15/18 / #20180046721

Systems and methods for automatic customization of content filtering

Exemplary embodiments include a system and method for Automatic Customization of Content Filtering (ACCF). The method includes receiving a search string from a user, creating a first filter based on the search string and searching different types of content stored in different content locations based on the first filter. The... Massachusetts Institute Of Technology

02/15/18 / #20180046815

Method and secure communication

... Massachusetts Institute Of Technology

02/15/18 / #20180047160

Linear-based eulerian motion modulation

In an embodiment, a method converts two images to a transform representation in a transform domain. For each spatial position, the method examines coefficients representing a neighborhood of the spatial position that is spatially the same across each of the two images. The method calculates a first vector in the... Massachusetts Institute Of Technology

02/15/18 / #20180048042

Rechargeable electrochemical system using transition metal promoter

An electrochemical system can include transition metal nanoparticles as a promoter for an electrode. The transition metal nanoparticles can include molybdenum (Mo), chromium (Cr), and/or the oxides thereof, which can lower recharge potentials and enhance the efficiency. These promoters promote especially the generation of oxygen and this for several cycles... Massachusetts Institute Of Technology

02/15/18 / #20180048061

Foam radiator

A novel system and method for creating a lightweight antenna is disclosed. Each lightweight antenna is formed using a foam material. This foam material is coated with a machinable material, which is machined to the desired dimensions. The machinable material is then plated with a metal. This creates a radiator... Massachusetts Institute Of Technology

02/15/18 / #20180048340

Equalization of receiver

Methods and systems for equalization of a first receiver. A method may include receiving an input signal at the first receiver. The method may also include receiving the input signal at a second receiver. The method may further include determining, from an output response of the second receiver, an estimate... Massachusetts Institute Of Technology

02/08/18 / #20180036333
02/08/18 / #20180036415

Drug delivery polymer and uses thereof

... Massachusetts Institute Of Technology

02/08/18 / #20180039036

Thermally-drawn fiber including devices

There is provided herein a fiber including a fiber body with a fiber body material having a longitudinal axis along a fiber body length. A plurality of devices is disposed as a linear sequence of devices within the fiber body. Each device includes at least one electrical contact pad. At... Massachusetts Institute Of Technology

02/08/18 / #20180039859

Joint acoustic and visual processing

An approach to joint acoustic and visual processing associates images with corresponding audio signals, for example, for the retrievals of images according to voice queries. A set of paired images and audio signals are processed without requiring transcription, segmentation, or annotation of either the images or the audio. This processing... Massachusetts Institute Of Technology

02/08/18 / #20180040663

Photodiode array structure for cross talk suppression

There is provided an avalanche photodiode array that includes a plurality of avalanche photodiodes. Each avalanche photodiode in the array includes a stack of active photodiode materials. The stack of active photodiode materials includes a first electrical contact layer, a second electrical contact layer; an absorber material layer and an... Massachusetts Institute Of Technology

02/08/18 / #20180040749

Semiconductor nanocrystals

A semiconductor nanocrystal include a first semiconductor material and have a luminescence quantum yield of at least 10%, at least 20%, or at least 30%. The nanocrystal can be substantially free of toxic elements. Populations of the nanocrystals can have an emission FWHM of no greater than 0.35 eV.... Massachusetts Institute Of Technology

02/01/18 / #20180028081

Image-guided closed-loop robotic system for automated whole-cell patch clamping electrophysiology of neurons in vivo

In an automated methodology for in vivo image-guided cell patch clamping, a cell patch clamping device is moved into position and targeted to a specific cell using automated image-guided techniques. Cell contact is determined by analyzing the temporal series of measured resistance levels at the clamping device as it is... Massachusetts Institute Of Technology

02/01/18 / #20180028962

Systems and methods incorporating ionic liquids for electrochemically mediated capturing of lewis acid gases

The present invention generally relates to methods and systems for capturing a Lewis acid gas (e.g., CO2). In some embodiments, the methods and systems utilize an ionic liquid incorporated into one or more electrochemical cells.... Massachusetts Institute Of Technology

02/01/18 / #20180030213

Block co-poly(metal organic nanostructures) (bcpmons) and uses thereof

The present disclosure provides (block co-polymer)-(metal organic framework) conjugates (BCPMOFs), such as (block co-polymer)-(metal organic nanostructure) conjugates (BCPMONs), and thermoplastic elastomers, gels, and compositions thereof. Exemplary BCPMONs include (block co-polymer)-(metal organic cage) conjugates (BCPMOCs), (block co-polymer)-(metal organic paddlewheel) conjugates, and (block co-polymer)-(metal organic square) conjugates, such as BCPMONs of Formula... Massachusetts Institute Of Technology

Patent Packs
02/01/18 / #20180030515

Droplet-based composite single-cell nucleic acid analysis

The present invention generally relates to a combination of molecular barcoding and emulsion-based microfluidics to isolate, lyse, barcode, and prepare nucleic acids from individual cells in a high-throughput manner.... Massachusetts Institute Of Technology

02/01/18 / #20180032039

Controlling dynamical systems with bounded probability of failure

A computer-based method controls a dynamical system in an uncertain environment within a bounded probability of failure. The dynamical system has a state space and a control space. The method includes diffusing a risk constraint corresponding to the bounded probability of failure into a martingale that represents a level of... Massachusetts Institute Of Technology

02/01/18 / #20180032838

Deviation magnification: revealing departures from ideal geometries

Geometries of the structures and objects deviate from their idealized models, while not always visible to the naked eye. Embodiments of the present invention reveal and visualize such subtle geometric deviations, which can contain useful, surprising information. In an embodiment of the present invention, a method can include fitting a... Massachusetts Institute Of Technology

02/01/18 / #20180034031

Lithium-air battery separators and related compositions

Battery separators for lithium-air batteries are provided. In some embodiments, a lithium-air battery may comprise one or more electrochemical cells including an anode, a cathode, an electrolyte, and a battery separator positioned between the anode and the cathode. The battery separator may comprise a porous membrane having a lithium ion... Massachusetts Institute Of Technology

02/01/18 / #20180034090

High energy density redox flow device

Redox flow devices are described in which at least one of the positive electrode or negative electrode-active materials is a semi-solid or is a condensed ion-storing electroactive material, and in which at least one of the electrode-active materials is transported to and from an assembly at which the electrochemical reaction... Massachusetts Institute Of Technology

01/25/18 / #20180020948

Rf attenuation measurement system and method

In part, disclosure relates to a monitoring system for monitoring RF attenuation of a material. In one embodiment, the system includes a plurality of transmitting antennas; an RF generator having a first output terminal in electrical communication with each of the plurality of transmitting antennas and a second output terminal;... Massachusetts Institute Of Technology

01/25/18 / #20180021260

Artificial cell constructs for cellular manipulation

The present invention contemplates induction of immunological tolerance thereby providing permanent allograft acceptance. This method obviates the need for a lifelong regimen of immunosuppressive agents which can increase the risk of infection, autoimmunity, and cancer. Immunological tolerance is thought to be mediated by regulatory T lymphocytes (Treg cells) with immunosuppressive... Massachusetts Institute Of Technology

01/25/18 / #20180021455

Receptor-targeted nanoparticles for enhanced transcytosis mediated drug delivery

Receptor-targeted nanoparticles (R-NPs) are provided for selective transport into and through targeted tissues of therapeutic, prophylactic and diagnostic agents. R-NPs can include polymeric particle, lipid particles, inorganic particles, or a combination thereof with a targeting moiety selective for binding to a receptor on the cells where the agent is to... Massachusetts Institute Of Technology

01/25/18 / #20180025110

Analyzing characteristics of genomic regions of a genome

Embodiments of techniques for analyzing one or more genomic regions of a genome of an organism. Data about a genomic region may be analyzed to determine an information content of the genomic region, which may indicate an amount of information provided by the genomic region. The data about the genomic... Massachusetts Institute Of Technology

01/25/18 / #20180025182

Phosphor-loaded waveguide

An improved waveguide is disclosed. The waveguide utilizes a luminescent material disposed within or around its perimeter to introduce additional light into the waveguide. For example, the waveguide may include a plurality of planar layers having different refractive indexes. A luminescent material may be disposed along the outer edge of... Massachusetts Institute Of Technology

01/25/18 / #20180026185

Far-infrared detection using weyl semimetals

The generation of photocurrent in an ideal two-dimensional Dirac spectrum is symmetry forbidden. In sharp contrast, a three-dimensional Weyl semimetal can generically support significant photocurrent due to the combination of inversion symmetry breaking and finite tilts of the Weyl spectrum. To realize this photocurrent, a noncentrosymmetric Weyl semimetal is coupled... Massachusetts Institute Of Technology

01/25/18 / #20180026801

Waveguide with dielectric light reflectors

An improved waveguide is disclosed. The waveguide comprises four or five layers, an inner core polymer, one or two layers of outer cladding polymer either on one side of the core of sandwiching the inner core polymer, and two layers of a dielectric reflector sandwiching the outer cladding polymer. The... Massachusetts Institute Of Technology

01/18/18 / #20180015167

Crosslinkable trehalose for the covalent incorporation in hydrogels and methods of use

Methods of controlled delivery of bioactive therapeutics are provided. Compositions comprising therapeutic implants are provided.... Massachusetts Institute Of Technology

01/18/18 / #20180015174

Synthetic nanoparticles for delivery of immunomodulatory compounds

The present disclosure provides a synthetic nanoparticle comprising a peptide nucleic acid (PNA) oligomer conjugated to a lipid, wherein the PNA oligomer noncovalently complexes with an immunomodulatory compound, thereby forming a nanoparticle. The nanoparticles are useful to elicit immune responses and can be used to treat a broad range of... Massachusetts Institute Of Technology

01/18/18 / #20180015296

Optogenetic control of endothelial cells

The invention features methods for regulating vascular properties by controlling the membrane properties of endothelial cells using optogenetics and light. The invention features methods to transport therapeutics across the vascular barrier into tissues such as the brain and the lung, with high spatial and temporal precision, and for controlling vascular... Massachusetts Institute Of Technology

01/18/18 / #20180016282

Inhibitors of histone deacetylase

... Massachusetts Institute Of Technology

01/18/18 / #20180016539

Disruption and field enabled delivery of compounds and compositions into cells

A microfluidic system for causing perturbations in a cell membrane includes (a) a microfluidic channel defining a lumen and configured such that a cell suspended in a buffer can pass there through, and (b) source or emitter of an energy field. The microfluidic channel may include a cell-deforming constriction. A... Massachusetts Institute Of Technology

01/18/18 / #20180016633

Sieve valves, microfluidic circuits, microfluidic devices, kits, and methods for isolating an analyte

The invention further provides methods of using the device for the analysis of samples comprising cells.... Massachusetts Institute Of Technology

01/18/18 / #20180016998

Fuel management system for variable ethanol octane enhancement of gasoline engines

Fuel management system for efficient operation of a spark ignition gasoline engine. Injectors inject an anti-knock agent such as ethanol directly into a cylinder of the engine. A fuel management microprocessor system controls injection of the anti-knock agent so as to control knock and minimize that amount of the anti-knock... Massachusetts Institute Of Technology

01/18/18 / #20180019421

Transparent photovoltaic cells

A transparent photovoltaic cell and method of making are disclosed. The photovoltaic cell may include a transparent substrate and a first active material overlying the substrate. The first active material may have a first absorption peak at a wavelength greater than about 650 nanometers. A second active material is disposed... Massachusetts Institute Of Technology

01/11/18 / #20180008687

Nanoparticle conjugates of highly potent toxins and intraperitoneal administration of nanoparticles for treating or imaging cancer

Disclosed are methods of treating cancer of the intraperitoneal cavity using compositions comprising nanoparticles without targeting agents. In addition, nanoparticles are described that comprise a highly toxic anticancer agent (e.g., an anticancer agent having an IC50 less than 1 nM) covalently bound via a linker to a triblock copolymer. Other... Massachusetts Institute Of Technology

01/11/18 / #20180009001

Methods for the vapor phase deposition of polymer thin films

Disclosed are methods for forming thin polymeric films on a surface of an article by deposition from the vapor phase. In certain embodiments, the method comprises depositing the polymeric film in situ inside a space or enclosure contained within the article. In other embodiments, the method comprises depositing a film... Massachusetts Institute Of Technology

01/11/18 / #20180009110

Discrete assemblers utilizing conventional motion systems

An alternative to additive manufacturing is disclosed, introducing an end-to-end workflow in which discrete building blocks are reversibly joined to produce assemblies called digital materials. Described is the design of the bulk-material building blocks and the devices that are assembled from them. Detailed is the design and implementation of an... Massachusetts Institute Of Technology

01/11/18 / #20180009850

Influenza treatment and/or characterization, human-adapted ha polypeptides; vaccines

The present invention provides, among other things, methods, reagents, and systems for the treatment, detection, analysis, and/or characterization of influenza infections.... Massachusetts Institute Of Technology

01/11/18 / #20180010091

Hydrogel comprising a scaffold macromer crosslinked with a peptide and a recognition motif

Methods of forming, dissolving, and functionalizing an extracellular matrix gel on demand based on cross-linking, modification, and dissolution of hydrogels using transpeptidase (e.g. sortase) are disclosed. Also provided are hydrogels comprising one or more macromers crosslinked to a mixture of peptides, wherein all or a portion of the peptides in... Massachusetts Institute Of Technology

01/11/18 / #20180010134

Delivery, use and therapeutic applications of the crispr-cas systems and compositions for modeling competition fo multiple cancer mutations in vivo

The invention involves inducing 3-50 or more mutations (e.g., any whole number between 3 and 50 of mutations, with it noted that in some embodiments there can be up to 16 different RNA(s), e.g., sgRNAs each having its own a promoter, in a vector, such as AAV, and that when... Massachusetts Institute Of Technology

01/11/18 / #20180010621

Methods and shape control

In exemplary implementations of this invention, a shape controller controls the shape of a bladder as the bladder inflates. The shape controller includes a first set of regions and a second set of regions. The second set of regions is more flexible than the first set of regions. The shape... Massachusetts Institute Of Technology

01/11/18 / #20180010911

Ground-based system for geolocation of perpetrators of aircraft laser strikes

Laser light source geolocation. The system includes two spaced-apart ground based sensors for receiving light from a laser source that has been off-axis scattered by air molecules and particulates to form scattered light imagery. A processor operates on the imagery from the two sensors to geolocate the laser light source... Massachusetts Institute Of Technology

01/11/18 / #20180010969

Directional force sensing element and system

A directional force sensor and sensing system are described. The directional force sensor includes a leaf spring and one or more load sensors disposed about the leaf spring such that in response to a force applied to the leaf spring, the one or more load sensors provide a signal. A... Massachusetts Institute Of Technology

01/11/18 / #20180011072

Systems and methods related to optical nanosensors comprising photoluminescent nanostructures

Systems and methods related to optical nanosensors comprising photoluminescent nanostructures are generally described.... Massachusetts Institute Of Technology

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01/11/18 / #20180012014

Systems and methods evaluating password complexity and strength

A password evaluation engine used to evaluate a user's password that redefines the concepts of password complexity and password strength is discussed. Password complexity may be calculated by the evaluation engine so as to take into account the amount of knowledge possessed by a potential attacker, seeking to crack the... Massachusetts Institute Of Technology

01/11/18 / #20180012932

Interconnect structures for assembly of semiconductor structures including superconducting integrated circuits

A multi-layer semiconductor structure includes a first semiconductor structure and a second semiconductor structure, with at least one of the first and second semiconductor structures provided as a superconducting semiconductor structure. The multi-layer semiconductor structure also includes one or more interconnect structures. Each of the interconnect structures is disposed between... Massachusetts Institute Of Technology

01/11/18 / #20180013052

Qubit and coupler circuit structures and coupling techniques

Quantum bit (qubit) circuits, coupler circuit structures and coupling techniques are described. Such circuits and techniques may be used to provide multi-qubit circuits suitable for use in multichip modules (MCMs).... Massachusetts Institute Of Technology








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