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Massachusetts Institute Of Technology patents


Recent patent applications related to Massachusetts Institute Of Technology. Massachusetts Institute Of Technology is listed as an Agent/Assignee. Note: Massachusetts Institute Of Technology may have other listings under different names/spellings. We're not affiliated with Massachusetts Institute Of Technology, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "M" | Massachusetts Institute Of Technology-related inventors


Systems and methods for hyperspectral imaging

A method, and corresponding system, can include identifying a plurality of wavelength spectral band components in hyperspectral image data, the spectral band components corresponding to mutually distinct sources of image contrast. An intensity image corresponding to each respective spectral band component can be calculated, followed by combining the respective intensity... Massachusetts Institute Of Technology

Use and production of chd8+/- transgenic animals with behavioral phenotypes characteristic of autism spectrum disorder

The invention involves inducing a plurality e.g., 3-50 or more mutations (e.g., any whole number between 3 and 50 or more of mutations, with it noted that in some embodiments there can be up to 16 different RNA(s), e.g., sgRNAs each having its own a promoter, in a vector, such... Massachusetts Institute Of Technology

Timely address space randomization

A method for timely address space randomize includes loading a code region from a program binary to a first location within the address space, detecting, during execution of the program, an output-input call pair from the program and, in response to detecting the output-input call pair from the program: selecting... Massachusetts Institute Of Technology

Systems and methods for automatic customization of content filtering

Exemplary embodiments include a system and method for Automatic Customization of Content Filtering (ACCF). The method includes receiving a search string from a user, creating a first filter based on the search string and searching different types of content stored in different content locations based on the first filter. The... Massachusetts Institute Of Technology

Method and secure communication

... Massachusetts Institute Of Technology

Linear-based eulerian motion modulation

In an embodiment, a method converts two images to a transform representation in a transform domain. For each spatial position, the method examines coefficients representing a neighborhood of the spatial position that is spatially the same across each of the two images. The method calculates a first vector in the... Massachusetts Institute Of Technology

Rechargeable electrochemical system using transition metal promoter

An electrochemical system can include transition metal nanoparticles as a promoter for an electrode. The transition metal nanoparticles can include molybdenum (Mo), chromium (Cr), and/or the oxides thereof, which can lower recharge potentials and enhance the efficiency. These promoters promote especially the generation of oxygen and this for several cycles... Massachusetts Institute Of Technology

Foam radiator

A novel system and method for creating a lightweight antenna is disclosed. Each lightweight antenna is formed using a foam material. This foam material is coated with a machinable material, which is machined to the desired dimensions. The machinable material is then plated with a metal. This creates a radiator... Massachusetts Institute Of Technology

Equalization of receiver

Methods and systems for equalization of a first receiver. A method may include receiving an input signal at the first receiver. The method may also include receiving the input signal at a second receiver. The method may further include determining, from an output response of the second receiver, an estimate... Massachusetts Institute Of Technology

Drug delivery polymer and uses thereof

... Massachusetts Institute Of Technology

Thermally-drawn fiber including devices

There is provided herein a fiber including a fiber body with a fiber body material having a longitudinal axis along a fiber body length. A plurality of devices is disposed as a linear sequence of devices within the fiber body. Each device includes at least one electrical contact pad. At... Massachusetts Institute Of Technology

Joint acoustic and visual processing

An approach to joint acoustic and visual processing associates images with corresponding audio signals, for example, for the retrievals of images according to voice queries. A set of paired images and audio signals are processed without requiring transcription, segmentation, or annotation of either the images or the audio. This processing... Massachusetts Institute Of Technology

Photodiode array structure for cross talk suppression

There is provided an avalanche photodiode array that includes a plurality of avalanche photodiodes. Each avalanche photodiode in the array includes a stack of active photodiode materials. The stack of active photodiode materials includes a first electrical contact layer, a second electrical contact layer; an absorber material layer and an... Massachusetts Institute Of Technology

Semiconductor nanocrystals

A semiconductor nanocrystal include a first semiconductor material and have a luminescence quantum yield of at least 10%, at least 20%, or at least 30%. The nanocrystal can be substantially free of toxic elements. Populations of the nanocrystals can have an emission FWHM of no greater than 0.35 eV.... Massachusetts Institute Of Technology

Image-guided closed-loop robotic system for automated whole-cell patch clamping electrophysiology of neurons in vivo

In an automated methodology for in vivo image-guided cell patch clamping, a cell patch clamping device is moved into position and targeted to a specific cell using automated image-guided techniques. Cell contact is determined by analyzing the temporal series of measured resistance levels at the clamping device as it is... Massachusetts Institute Of Technology

Systems and methods incorporating ionic liquids for electrochemically mediated capturing of lewis acid gases

The present invention generally relates to methods and systems for capturing a Lewis acid gas (e.g., CO2). In some embodiments, the methods and systems utilize an ionic liquid incorporated into one or more electrochemical cells.... Massachusetts Institute Of Technology

Block co-poly(metal organic nanostructures) (bcpmons) and uses thereof

The present disclosure provides (block co-polymer)-(metal organic framework) conjugates (BCPMOFs), such as (block co-polymer)-(metal organic nanostructure) conjugates (BCPMONs), and thermoplastic elastomers, gels, and compositions thereof. Exemplary BCPMONs include (block co-polymer)-(metal organic cage) conjugates (BCPMOCs), (block co-polymer)-(metal organic paddlewheel) conjugates, and (block co-polymer)-(metal organic square) conjugates, such as BCPMONs of Formula... Massachusetts Institute Of Technology

Droplet-based composite single-cell nucleic acid analysis

The present invention generally relates to a combination of molecular barcoding and emulsion-based microfluidics to isolate, lyse, barcode, and prepare nucleic acids from individual cells in a high-throughput manner.... Massachusetts Institute Of Technology

Controlling dynamical systems with bounded probability of failure

A computer-based method controls a dynamical system in an uncertain environment within a bounded probability of failure. The dynamical system has a state space and a control space. The method includes diffusing a risk constraint corresponding to the bounded probability of failure into a martingale that represents a level of... Massachusetts Institute Of Technology

Deviation magnification: revealing departures from ideal geometries

Geometries of the structures and objects deviate from their idealized models, while not always visible to the naked eye. Embodiments of the present invention reveal and visualize such subtle geometric deviations, which can contain useful, surprising information. In an embodiment of the present invention, a method can include fitting a... Massachusetts Institute Of Technology

Lithium-air battery separators and related compositions

Battery separators for lithium-air batteries are provided. In some embodiments, a lithium-air battery may comprise one or more electrochemical cells including an anode, a cathode, an electrolyte, and a battery separator positioned between the anode and the cathode. The battery separator may comprise a porous membrane having a lithium ion... Massachusetts Institute Of Technology

High energy density redox flow device

Redox flow devices are described in which at least one of the positive electrode or negative electrode-active materials is a semi-solid or is a condensed ion-storing electroactive material, and in which at least one of the electrode-active materials is transported to and from an assembly at which the electrochemical reaction... Massachusetts Institute Of Technology

Rf attenuation measurement system and method

In part, disclosure relates to a monitoring system for monitoring RF attenuation of a material. In one embodiment, the system includes a plurality of transmitting antennas; an RF generator having a first output terminal in electrical communication with each of the plurality of transmitting antennas and a second output terminal;... Massachusetts Institute Of Technology

Artificial cell constructs for cellular manipulation

The present invention contemplates induction of immunological tolerance thereby providing permanent allograft acceptance. This method obviates the need for a lifelong regimen of immunosuppressive agents which can increase the risk of infection, autoimmunity, and cancer. Immunological tolerance is thought to be mediated by regulatory T lymphocytes (Treg cells) with immunosuppressive... Massachusetts Institute Of Technology

Receptor-targeted nanoparticles for enhanced transcytosis mediated drug delivery

Receptor-targeted nanoparticles (R-NPs) are provided for selective transport into and through targeted tissues of therapeutic, prophylactic and diagnostic agents. R-NPs can include polymeric particle, lipid particles, inorganic particles, or a combination thereof with a targeting moiety selective for binding to a receptor on the cells where the agent is to... Massachusetts Institute Of Technology

Analyzing characteristics of genomic regions of a genome

Embodiments of techniques for analyzing one or more genomic regions of a genome of an organism. Data about a genomic region may be analyzed to determine an information content of the genomic region, which may indicate an amount of information provided by the genomic region. The data about the genomic... Massachusetts Institute Of Technology

Phosphor-loaded waveguide

An improved waveguide is disclosed. The waveguide utilizes a luminescent material disposed within or around its perimeter to introduce additional light into the waveguide. For example, the waveguide may include a plurality of planar layers having different refractive indexes. A luminescent material may be disposed along the outer edge of... Massachusetts Institute Of Technology

Far-infrared detection using weyl semimetals

The generation of photocurrent in an ideal two-dimensional Dirac spectrum is symmetry forbidden. In sharp contrast, a three-dimensional Weyl semimetal can generically support significant photocurrent due to the combination of inversion symmetry breaking and finite tilts of the Weyl spectrum. To realize this photocurrent, a noncentrosymmetric Weyl semimetal is coupled... Massachusetts Institute Of Technology

Waveguide with dielectric light reflectors

An improved waveguide is disclosed. The waveguide comprises four or five layers, an inner core polymer, one or two layers of outer cladding polymer either on one side of the core of sandwiching the inner core polymer, and two layers of a dielectric reflector sandwiching the outer cladding polymer. The... Massachusetts Institute Of Technology

Crosslinkable trehalose for the covalent incorporation in hydrogels and methods of use

Methods of controlled delivery of bioactive therapeutics are provided. Compositions comprising therapeutic implants are provided.... Massachusetts Institute Of Technology

Synthetic nanoparticles for delivery of immunomodulatory compounds

The present disclosure provides a synthetic nanoparticle comprising a peptide nucleic acid (PNA) oligomer conjugated to a lipid, wherein the PNA oligomer noncovalently complexes with an immunomodulatory compound, thereby forming a nanoparticle. The nanoparticles are useful to elicit immune responses and can be used to treat a broad range of... Massachusetts Institute Of Technology

Optogenetic control of endothelial cells

The invention features methods for regulating vascular properties by controlling the membrane properties of endothelial cells using optogenetics and light. The invention features methods to transport therapeutics across the vascular barrier into tissues such as the brain and the lung, with high spatial and temporal precision, and for controlling vascular... Massachusetts Institute Of Technology

Inhibitors of histone deacetylase

... Massachusetts Institute Of Technology

Disruption and field enabled delivery of compounds and compositions into cells

A microfluidic system for causing perturbations in a cell membrane includes (a) a microfluidic channel defining a lumen and configured such that a cell suspended in a buffer can pass there through, and (b) source or emitter of an energy field. The microfluidic channel may include a cell-deforming constriction. A... Massachusetts Institute Of Technology

01/18/18 / #20180016633

Sieve valves, microfluidic circuits, microfluidic devices, kits, and methods for isolating an analyte

The invention further provides methods of using the device for the analysis of samples comprising cells.... Massachusetts Institute Of Technology

01/18/18 / #20180016998

Fuel management system for variable ethanol octane enhancement of gasoline engines

Fuel management system for efficient operation of a spark ignition gasoline engine. Injectors inject an anti-knock agent such as ethanol directly into a cylinder of the engine. A fuel management microprocessor system controls injection of the anti-knock agent so as to control knock and minimize that amount of the anti-knock... Massachusetts Institute Of Technology

01/18/18 / #20180019421

Transparent photovoltaic cells

A transparent photovoltaic cell and method of making are disclosed. The photovoltaic cell may include a transparent substrate and a first active material overlying the substrate. The first active material may have a first absorption peak at a wavelength greater than about 650 nanometers. A second active material is disposed... Massachusetts Institute Of Technology

01/11/18 / #20180008687

Nanoparticle conjugates of highly potent toxins and intraperitoneal administration of nanoparticles for treating or imaging cancer

Disclosed are methods of treating cancer of the intraperitoneal cavity using compositions comprising nanoparticles without targeting agents. In addition, nanoparticles are described that comprise a highly toxic anticancer agent (e.g., an anticancer agent having an IC50 less than 1 nM) covalently bound via a linker to a triblock copolymer. Other... Massachusetts Institute Of Technology

01/11/18 / #20180009001

Methods for the vapor phase deposition of polymer thin films

Disclosed are methods for forming thin polymeric films on a surface of an article by deposition from the vapor phase. In certain embodiments, the method comprises depositing the polymeric film in situ inside a space or enclosure contained within the article. In other embodiments, the method comprises depositing a film... Massachusetts Institute Of Technology

01/11/18 / #20180009110

Discrete assemblers utilizing conventional motion systems

An alternative to additive manufacturing is disclosed, introducing an end-to-end workflow in which discrete building blocks are reversibly joined to produce assemblies called digital materials. Described is the design of the bulk-material building blocks and the devices that are assembled from them. Detailed is the design and implementation of an... Massachusetts Institute Of Technology

01/11/18 / #20180009850

Influenza treatment and/or characterization, human-adapted ha polypeptides; vaccines

The present invention provides, among other things, methods, reagents, and systems for the treatment, detection, analysis, and/or characterization of influenza infections.... Massachusetts Institute Of Technology

01/11/18 / #20180010091

Hydrogel comprising a scaffold macromer crosslinked with a peptide and a recognition motif

Methods of forming, dissolving, and functionalizing an extracellular matrix gel on demand based on cross-linking, modification, and dissolution of hydrogels using transpeptidase (e.g. sortase) are disclosed. Also provided are hydrogels comprising one or more macromers crosslinked to a mixture of peptides, wherein all or a portion of the peptides in... Massachusetts Institute Of Technology

01/11/18 / #20180010134

Delivery, use and therapeutic applications of the crispr-cas systems and compositions for modeling competition fo multiple cancer mutations in vivo

The invention involves inducing 3-50 or more mutations (e.g., any whole number between 3 and 50 of mutations, with it noted that in some embodiments there can be up to 16 different RNA(s), e.g., sgRNAs each having its own a promoter, in a vector, such as AAV, and that when... Massachusetts Institute Of Technology

01/11/18 / #20180010621

Methods and shape control

In exemplary implementations of this invention, a shape controller controls the shape of a bladder as the bladder inflates. The shape controller includes a first set of regions and a second set of regions. The second set of regions is more flexible than the first set of regions. The shape... Massachusetts Institute Of Technology

01/11/18 / #20180010911

Ground-based system for geolocation of perpetrators of aircraft laser strikes

Laser light source geolocation. The system includes two spaced-apart ground based sensors for receiving light from a laser source that has been off-axis scattered by air molecules and particulates to form scattered light imagery. A processor operates on the imagery from the two sensors to geolocate the laser light source... Massachusetts Institute Of Technology

01/11/18 / #20180010969

Directional force sensing element and system

A directional force sensor and sensing system are described. The directional force sensor includes a leaf spring and one or more load sensors disposed about the leaf spring such that in response to a force applied to the leaf spring, the one or more load sensors provide a signal. A... Massachusetts Institute Of Technology

01/11/18 / #20180011072

Systems and methods related to optical nanosensors comprising photoluminescent nanostructures

Systems and methods related to optical nanosensors comprising photoluminescent nanostructures are generally described.... Massachusetts Institute Of Technology

01/11/18 / #20180012014

Systems and methods evaluating password complexity and strength

A password evaluation engine used to evaluate a user's password that redefines the concepts of password complexity and password strength is discussed. Password complexity may be calculated by the evaluation engine so as to take into account the amount of knowledge possessed by a potential attacker, seeking to crack the... Massachusetts Institute Of Technology

01/11/18 / #20180012932

Interconnect structures for assembly of semiconductor structures including superconducting integrated circuits

A multi-layer semiconductor structure includes a first semiconductor structure and a second semiconductor structure, with at least one of the first and second semiconductor structures provided as a superconducting semiconductor structure. The multi-layer semiconductor structure also includes one or more interconnect structures. Each of the interconnect structures is disposed between... Massachusetts Institute Of Technology

01/11/18 / #20180013052

Qubit and coupler circuit structures and coupling techniques

Quantum bit (qubit) circuits, coupler circuit structures and coupling techniques are described. Such circuits and techniques may be used to provide multi-qubit circuits suitable for use in multichip modules (MCMs).... Massachusetts Institute Of Technology

01/04/18 / #20180000428

Methods and systems for pre-symptomatic detection of exposure to an agent

Systems and methods for predicting exposure to an agent. One or more features are extracted from physiological data. For each respective classifier, (i) the respective classifier is identified, wherein the respective classifier is trained using training data for a respective physiological state, (ii) the respective classifier is applied to the... Massachusetts Institute Of Technology

01/04/18 / #20180000956

Method and process for quantitative evaluation of pharmacokinetics, therapeutic effects and safety of delivery of drug compounds to the inner ear for treatment of auditory disease

The present disclosure provides compositions and methods for treating an auditory disease in a subject in need thereof comprising administering an effective amount of a gel-based precursor that includes an inner ear-specific therapeutic compound directly into the cochlea of the subject.... Massachusetts Institute Of Technology

01/04/18 / #20180001375

Methods and actuated fabricator

In exemplary implementations of this invention, an actuated fabricator deposits structural elements (e.g., tensile structural elements) in a 3D pattern over large displacements. The fabricator is supported by at least three elongated support members. It includes onboard actuators that translate the fabricator relative to the ends of the support members.... Massachusetts Institute Of Technology

01/04/18 / #20180001963

Stepped cambered planing hull

Various embodiments are disclosed for a stepped cambered planing hull for a boat including a swept back cambered planing surface having a non-linear distribution of camber. The non-linear distribution of camber along the swept back cambered planing surface may enable stepped cambered planing hulls having high deadrise (i.e., greater than... Massachusetts Institute Of Technology

01/04/18 / #20180002550

Spray-coating method with particle alignment control

A simple spray coating process can be utilized to create epoxy/HNT nanocomposites with vertically aligned nanotubes. Important mechanical properties such as modulus and hardness values can be optimized and enhanced by controlling the level of nanotube dispersion during processing and the final orientation of the nanotubes. Thus, a technologically relevant... Massachusetts Institute Of Technology

01/04/18 / #20180003696

Gene editing through microfluidic delivery

Gene editing can be performed by introducing gene-editing components into a cell by mechanical cell disruption. Related apparatus, systems, techniques, and articles are also described. The methods and systems of the invention solve the problem of intracellular delivery of gene editing components and gene editing complexes to target cells. The... Massachusetts Institute Of Technology

01/04/18 / #20180007264

Imaging system for immersive surveillance

Security guards at big facilities, such as airports, monitor multiple screens that display images from individual surveillance cameras dispersed throughout the facility. If a guard zooms with a particular camera, he will lose image resolution, along with perspective on the surrounding area. Embodiments of the inventive Imaging System for Immersive... Massachusetts Institute Of Technology

12/28/17 / #20170368508

Porous materials and methods including nanoporous materials for water filtration

Embodiments described herein relate to porous materials that may be employed in various filtration, purification, and/or separation applications. In some cases, the porous materials may be thin, flexible, and fabricated with control over average pore size and/or the spatial distribution of pores. Such porous materials may be useful in, for... Massachusetts Institute Of Technology

12/28/17 / #20170368679

Bipedal isotropic lattice locomoting explorer: robotic platform for locomotion and manipulation of discrete lattice structures and lightweight space structures

A robotic platform for traversing and manipulating a modular 3D lattice structure is described. The robot is designed specifically for its tasks within a structured environment, and is simplified in terms of its numbers of degrees of freedom (DOF). This allows for simpler controls and a reduction of mass and... Massachusetts Institute Of Technology

12/28/17 / #20170368755

Methods and 3d printing of point cloud data

An unorganized point cloud may be created by an optical 3D scanner that scans a physical object, or by computer simulation. The point cloud may be converted into binary raster layers, which encode material deposition instructions for a multi-material 3D printer. In many cases, this conversion—from point cloud to binary... Massachusetts Institute Of Technology

12/28/17 / #20170368759

Systems, devices, and methods for precision locating and assembly of additively manufactured components

Methods, systems, and devices for precision locating additively manufactured components for assembly and/or post processing manufacturing are provided for herein. In some embodiments, at least one component can be additively manufactured to include one or more kinematic features on one or more surfaces of the component. The kinematic feature(s) can... Massachusetts Institute Of Technology

12/28/17 / #20170369878

Microrna combinations for anti-cancer therapeutics

Described herein are methods and compositions of combinations of microRNAs that enhance the sensitivity of cancer cells to chemotherapeutic agents or reduce proliferation of cancer cells. Also described herein are methods for the identification of combinations of microRNAs that result in desired effects.... Massachusetts Institute Of Technology

12/28/17 / #20170369937

Hic: identifying interactions between genomic loci

The disclosed Hi-C protocol can identify genomic loci that are spatially co-located in vivo. These spatial co-locations may include, but are not limited to, intrachromosomal interactions and/or interchromosomal interactions. Hi-C techniques may be applied to many different scales of interest. For example, on a large scale, Hi-C techniques can be... Massachusetts Institute Of Technology

12/28/17 / #20170371142

Circular scanning technique for large area inspection

Described embodiments provide a method of generating an image of a region of interest of a target object. A plurality of concentric circular scan trajectories are determined to sample the region of interest. Each of the concentric circular scan trajectories have a radius incremented from an inner-most concentric circular scan... Massachusetts Institute Of Technology

Patent Packs
12/28/17 / #20170372201

Secure training of multi-party deep neural network

A deep neural network may be trained on the data of one or more entities, also know as Alices. An outside computing entity, also known as a Bob, may assist in these computations, without receiving access to Alices' data. Data privacy may be preserved by employing a “split” neural network.... Massachusetts Institute Of Technology

12/28/17 / #20170373044

Interconnect structures and semiconductor structures for assembly of cryogenic electronic packages

A cryogenic electronic package includes at least two superconducting and/or conventional metal semiconductor structures. Each of the semiconductor structures includes a substrate and a superconducting trace. Additionally, each of the semiconductor structures includes a passivation layer and one or more under bump metal (UBM) structures. The cryogenic electronic package also... Massachusetts Institute Of Technology

12/28/17 / #20170373609

High-frequency variable load inverter and related techniques

Inverter systems, circuits and associated control techniques for providing efficient delivery of high-frequency (HF) power and radio-frequency (RF) power into variable load impedances while maintaining resistive/inductive loading of the constituent inverters for zero voltage switching (ZVS) are described. The inverter architecture and associated control techniques for providing efficient delivery of... Massachusetts Institute Of Technology

12/28/17 / #20170373700

Analog to digital computations in biological systems

Aspects of the present disclosure relate to analog signal processing circuits and methods for cellular computation.... Massachusetts Institute Of Technology

12/21/17 / #20170360850

Probiotic organisms for diagnosis, monitoring, and treatment of inflammatory bowel disease

Aspects of the present disclosure relate to genetically engineered organisms useful for the diagnosis and treatment of inflammatory bowel disease.... Massachusetts Institute Of Technology

12/21/17 / #20170362599

Front-end analog signal processing for cellular computation

Aspects of the present disclosure relate to analog signal processing circuits and methods for cellular computation.... Massachusetts Institute Of Technology

12/21/17 / #20170362609

Amphiphilic nanoparticles for codelivery of water-insoluble small molecules and rnai

Disclosed are copolymer micelles for simultaneous delivery of Cas9 mRNA and guide RNA for Cas9 CRISPR gene editing. Also disclosed are copolymer micelles for simultaneous delivery of a therapeutic or diagnostic nucleic acid and a cross-linking or alkylating anticancer agent.... Massachusetts Institute Of Technology

12/21/17 / #20170364452

Timely randomized memory protection

In a system executing a program, a method comprises detecting one or more input/output calls associated with the program and re-randomizing memory associated with the program in response to the one or more input/output calls. A related system is also described.... Massachusetts Institute Of Technology

12/21/17 / #20170364785

Ionic liquid carbon nanotube composites for wireless chemical sensing

A wireless sensor platform design and a single walled carbon nanotube/ionic liquid-based chemidosimeter system can incorporated into a highly sensitive and selective chemical hazard badge that can dosimetrically detect an analyte down to a sub parts-per-million concentration.... Massachusetts Institute Of Technology

12/21/17 / #20170365438

Compact modular cathode

Example compact modular electron beam units are provided that can be used to generate electron beams using field emitter elements. A modular electron beam unit may comprise an electron beam source including a base portion, at least one field emitter element coupled to the base portion, the field emitter element... Massachusetts Institute Of Technology

12/21/17 / #20170365726

Method and optoelectronic structure providing polysilicon photonic devices with different optical properties in different regions

Method and structural embodiments are described which provide an integrated structure using polysilicon material having different optical properties in different regions of the structure.... Massachusetts Institute Of Technology

12/21/17 / #20170365856

Virus scaffold for self-assembled, flexible and light lithium battery

A variety of compositions that include a metal oxide, films and batteries comprising one or more of the compositions, and methods of making the same.... Massachusetts Institute Of Technology

12/21/17 / #20170365900

Lithium ion conducting protective film and use

A lithium ion conducting protective film produced using a layer-by-layer assembly process. The lithium ion conducting protective film is assembled on a substrate by a sequential exposure of the substrate to a first poly(ethylene oxide) (PEO) layer including a cross-linking silane component on the first side of the substrate, a... Massachusetts Institute Of Technology

12/14/17 / #20170354363

Phonologically-based biomarkers for major depressive disorder

A system and a method for assessing a condition in a subject. Phones from speech of the subject are recognized, one or more prosodic or speech-excitation-source features of the phones are extracted, and an assessment of a condition of the subject, is generated based on a correlation between the features... Massachusetts Institute Of Technology

12/14/17 / #20170354609

Pharmaceutical tablet coating process by injection molding process technology

The disclosure describes an injection molding process for coating a tablet core to produce a coated pharmaceutical tablet, wherein the injection-molded coating is substantially continuous (e.g., completely covers the tablet core with no openings), and describes the resulting coated pharmaceutical tablet. The disclosure describes compositions for coatings and tablet cores... Massachusetts Institute Of Technology

Patent Packs
12/14/17 / #20170355799

Biocompatible coatings and hydrogels for reducing foreign body response and fibrosis

Zwitterionic polymers or biocompatible polymers with improved properties for cell encapsulation, coating of devices, or a combination thereof are described. The biocompatible polymer contains a zwitterionic monomer, a monomer with a reactive side chain, and optionally another hydrophobic monomer or a neutral hydrophilic monomer. The zwitterionic polymers are cross-linked with... Massachusetts Institute Of Technology

12/14/17 / #20170355945

Microfluidic device for three dimensional and compartmentalized coculture of neuronal and muscle cells, with functional force readout

The present subject matter provides a microfluidic device that enables the precise and repeatable three dimensional and compartmentalized coculture of muscle cells and neuronal cells. Related apparatus, systems, techniques, and articles are also described.... Massachusetts Institute Of Technology

12/14/17 / #20170356477

Articles and methods for levitating liquids on surfaces, and devices incorporating the same

Methods described herein provide a way to reduce or eliminate drag and adhesion of a substance flowing over a surface by creating a vapor cushion via evaporation of a phase-changing material of or on the surface or encapsulated within textures of the surface. The vapor cushion causes the flowing substance... Massachusetts Institute Of Technology

12/07/17 / #20170348176

High performance free rolling cable transmission

A mechanical transmission, tethered actuation system, an autonomous ankle exoskeleton design and method of their use employing a cable, pulleys and associated pulley housings to change angular transmission of linear force on the cable. The pulleys are linked by a ground link and the cable is threaded across and between... Massachusetts Institute Of Technology

12/07/17 / #20170348431

Drug delivery polymers and uses thereof

Described herein are platinum-based brush-arm star polymers (Pt-BASPs), or a pharmaceutical composition thereof, for delivery of platinum-based agents, such as oxaliplatin. Also provided are methods and kits involving the Pt-BASPs, or a pharmaceutical composition thereof, for treating proliferative diseases such as cancers (e.g., lung cancer, head-and-neck cancer, esophagus cancer, stomach... Massachusetts Institute Of Technology

12/07/17 / #20170349650

Immunoglobulins with reduced aggregation

The present disclosure relates to immunoglobulins with reduced aggregation and compositions, methods of generating such immunoglobulins with computational tools and methods of using such immunoglobulins particularly in the treatment and prevention of disease.... Massachusetts Institute Of Technology

12/07/17 / #20170349884

Production of differentiated enteroendocrine cells and insulin producing cells

A population of enteroendocrine cells (EEC) is obtained from a mammalian post-natal cell population, such as a population including post-natal stem cells, by treating the population with a plurality of small molecules that upregulate ChgA and promote differentiation of the cells to form the enteroendocrine cells. The upregulation of ChgA... Massachusetts Institute Of Technology

12/07/17 / #20170349894

Escorted and functionalized guides for crispr-cas systems

The present invention generally relates to CRISPR systems or complexes, such as those with an escorted guide RNA.... Massachusetts Institute Of Technology

12/07/17 / #20170349914

Delivery, use and therapeutic applications of crispr systems and compositions for genome editing as to hematopoietic stem cells (hscs)

The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are delivery systems and tissues or organ which are targeted as sites for delivery. Also provided are vectors and vector systems some of which encode one or... Massachusetts Institute Of Technology

12/07/17 / #20170349950

T cell balance gene expression, compositions of matters and methods of use thereof

This invention relates generally to compositions and methods for identifying the regulatory network that modulates, controls or otherwise influences T cell balance, for example, Th17 cell differentiation, maintenance and/or function, as well compositions and methods for exploiting the regulatory network that modulates, controls or otherwise influences T cell balance in... Massachusetts Institute Of Technology

12/07/17 / #20170353293

Method for transient change detection with adaptive sampling, and detector implementing the method

A method of detecting transient changes in the distribution of a discrete time series includes: operating in a sparse mode wherein, at sniff periods successively repeated at a first rate, at most K test phases are performed, K being an integer superior or equal to two, each test phase consisting... Massachusetts Institute Of Technology

11/30/17 / #20170341010

Compositions comprising metal organic frameworks for the uptake of compounds and related methods

Compositions and methods for adsorption of a species (e.g., ammonia, water, a halogen) comprising metal organic frameworks (MOFs) are generally provided. In some embodiments, a MOF comprises a plurality of metal ions, each coordinated with at least one ligand comprising at least two unsaturated N-heterocyclic aromatic groups arranged about an... Massachusetts Institute Of Technology

11/30/17 / #20170341034

Graphene oxide membranes and related methods

Membranes comprising graphene oxide sheets and associated filter media and methods are provided. In some embodiments, a membrane may comprise graphene oxide sheets that have undergone one or more chemical treatments. The chemical treatment(s) may impart beneficial properties to the membrane, such as a relatively small d-spacing, compatibility with a... Massachusetts Institute Of Technology

11/30/17 / #20170341316

Composite articles comprising non-linear elongated nanostructures and associated methods

The present disclosure relates to composite articles comprising non-linear elongated nanostructures and associated systems and methods. In certain embodiments, collections of carbon nanotubes or other elongated nanostructures can be used to provide mechanical reinforcement along multiple directions within a composite article.... Massachusetts Institute Of Technology

11/30/17 / #20170343553
11/30/17 / #20170344699

Water-soluble membrane proteins and methods for the preparation and use thereof

The present invention is directed to water-soluble membrane proteins, methods for the preparation thereof and methods of use thereof.... Massachusetts Institute Of Technology

11/30/17 / #20170346283

Systems and methods for modular dc microgrids with control of loads

The systems and methods described herein are directed towards a microgrid having modular power management units to control and regulate power to maintain a stable energy environment and provide peer-to-peer electricity sharing within the microgrid. The microgrid includes a power source to generate power for the microgrid, a source power... Massachusetts Institute Of Technology

11/23/17 / #20170332933

Deep brain source imaging with m/eeg and anatomical mri

A method for non-invasively resolving electrophysiological activity in sub-cortical structures located deep in the brain by comparing amplitude-insensitive M/EEG field patterns arising from activity in subcortical and cortical sources under physiologically relevant sparse constraints is disclosed. The method includes a sparse inverse solution for M/EEG subcortical source modeling. Specifically, the... Massachusetts Institute Of Technology

11/23/17 / #20170333304

Hydrogel particles, compositions, and methods

Hydrogel particles are provided that include a crosslinked polymer and a drug conjugated to the crosslinked polymer. The hydrogel particles may include a pH sensitive moiety and a redox sensitive moiety. The hydrogel particles also may be dispersed in a host hydrogel. Kits and methods of drug delivery and treatment... Massachusetts Institute Of Technology

11/23/17 / #20170333348

Mass production and size control of nanoparticles through controlled microvortices

Methods for making particles, such as nanoparticles, devices useful in the methods, and particles made by the method are described herein. The methods involves the use of microfluidic device, such that upon mixing solutions of the materials to form the particles (or a solution of the material or materials to... Massachusetts Institute Of Technology

11/23/17 / #20170333887

Catalysts for metathesis reactions including enantioselective olefin metathesis, and related methods

The present invention provides compositions comprising metal complexes, and related methods. In some embodiments, metal complexes of the invention may be useful as catalysts for chemical reactions, including metathesis reactions, wherein the catalysts exhibit enhanced activity and stereoselectivity. In some embodiments, the invention may advantageously provide metal complexes comprising a... Massachusetts Institute Of Technology

11/23/17 / #20170335334

Dna cloaking technologies

The disclosure relates to the use of steganographic methods to camouflage information encoded on nucleic acids. Specifically, the method comprising preparing a pool of recombinant nucleic acid constructs, wherein at least one of the constnjcts comprises the nucleic acid sequence to be camouflaged and wherein the pool is heterogeneous with... Massachusetts Institute Of Technology

11/23/17 / #20170335406

Metastasis specific splice variants of mena and uses thereof in diagnosis, prognosis and treatment of tumors

Methods and kits for diagnosis, prognosis and treatment of metastatic tumors are provided where the metastatic tumor is characterized by changes in expression of +++, ++ and/or 11a variants of Mena.... Massachusetts Institute Of Technology

11/23/17 / #20170335411

Correcting crosstalk in biological systems

Aspects of the present disclosure are directed to biosensing circuits that correct crosstalk.... Massachusetts Institute Of Technology

11/23/17 / #20170336102

Enhanced thermal stability on multi-metal filled cermet based spectrally selective solar absorbers

A spectrally selective solar absorber is described and comprises a substrate, double cermet layers comprising multi-metal nanoparticles embedded in a dielectrics matrix, and double antireflection layers deposited on cermet layers. The tungsten or titanium or tantalum infrared reflector layer suppressing the diffusion of substrate elements and multi-metal nanoparticles in the... Massachusetts Institute Of Technology

11/23/17 / #20170338943

Dna encryption technologies

In some aspects, the instant disclosure relates to the multiplexed encryption of information on nucleic acid molecules. In some aspects, the instant disclosure relates to a method of secure communication of information disseminated across at least one nucleic acid molecule, the method comprising (a) obtaining a modified keyboard comprising a... Massachusetts Institute Of Technology








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