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Massachusetts Institute Of Technology patents


Recent patent applications related to Massachusetts Institute Of Technology. Massachusetts Institute Of Technology is listed as an Agent/Assignee. Note: Massachusetts Institute Of Technology may have other listings under different names/spellings. We're not affiliated with Massachusetts Institute Of Technology, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "M" | Massachusetts Institute Of Technology-related inventors


 new patent  Extruder feed system

Extruder feed system. The system includes a pair of spaced-apart, internally and oppositely threaded rotatable elements for receiving and engaging a plastic filament material. ... Massachusetts Institute Of Technology

 new patent  Methods and apparatus for three-dimensional (3d) imaging

A method of imaging a scene includes estimating multiple three-dimensional (3d) representations, each of which corresponds to a respective portion of the scene. Neighboring portions of the scene area are at least partially overlapping. ... Massachusetts Institute Of Technology

 new patent  Selective solar absorbers with tuned oxygen deficiency and methods of fabrication thereof

Systems and methods disclosed herein are directed towards the fabrication of a solar absorber comprising an ir reflector layer deposited on a substrate; a first cermet layer deposited in contact with the ir reflector layer; a second cermet layer deposited in contact with the first cermet layer; a first anti-reflection coating layer deposited in contact with the second cermet layer; a second anti-reflection coating layer deposited in contact with the first anti-reflection coating layer. A sputtering process may be used to deposit some or all of the layers, and the ysz layers in each cermet layer may be deposited with a tuned partial oxygen pressure in order to form a layer that is oxygen-deficient.. ... Massachusetts Institute Of Technology

 new patent  Unbiased identification of double-strand breaks and genomic rearrangement by genome-wide insert capture sequencing

The invention provides for systems, methods, compositions, and kits for the complete characterization of targeted nuclease specificity which necessitates techniques that can assess the full possibility space of off-target activity and genomic stability following genome editing. Also provided are the materials and techniques which enable the comprehensive genomic stability accompanying a range of cellular perturbations, including genome editing (zfn, talen, crispr, and future technologies) and disease modeling among other applications.. ... Massachusetts Institute Of Technology

 new patent  Gene expression in bacteroides

Provided herein, in some aspects, are tools (e.g., methods, compositions and nucleic acids) for building genetic circuits in bacteroides and parabacteroides bacteria, as well as the bacteria containing the genetic circuits.. . ... Massachusetts Institute Of Technology

 new patent  Flexural digital material construction and transduction

Flexural digital materials are discrete parts that can be assembled into a lattice structure to produce an actuatable structure capable of coordinated reversible spatially-distributed deformation. The structure comprises a set of discrete flexural digital material units assembled according to a lattice geometry, with a majority of the discrete units being connected, or adapted to be connected, to at least two other units according to the geometry. ... Massachusetts Institute Of Technology

 new patent  Articles and methods for modifying condensation on surfaces

The articles and methods described herein provide a way to manipulate condensation on a surface by micro/nano-engineering textures on the surface and filling the spaces between the texture features with an impregnating liquid that is stably held therebetween or therewithin. The articles and methods allow droplets of water, or other condensed phases, even in micrometer size range, to easily shed from the surface, thereby enhancing contact between a condensing species and the condensing surface. ... Massachusetts Institute Of Technology

 new patent  Concentration control in filtration systems, and associated methods

Concentration control in filtration systems and associated methods are generally described. Streams originating from upstream filters and having similar concentrations of a target minor component and/or similar osmotic pressures can be mixed and subsequently filtered within additional filters. ... Massachusetts Institute Of Technology

 new patent  Controllably degradable compositions and methods

Methods for treating, adhering, or sealing biological tissue are provided. The methods include combining solutions containing a polymer component and a dendrimer component capable of reacting with each other, and at least one of the components includes a substituent capable of photoreversible dimerization that can be reversibly dimerized. ... Massachusetts Institute Of Technology

 new patent  Passive artificial knee

A passive artificial knee includes a knee hinge assembly defining a knee axis, a locking hinge assembly defining a locking axis, and a post linking the knee hinge assembly and the locking hinge assembly. A ground reaction force applied to the artificial knee posterior to the locking axis causes an interfering relation by compression of the locking hinge assembly and the knee hinge assembly during heel strike at early-stance gait phase of an individual wearing the artificial knee, thereby locking rotation of the post about the knee axis. ... Massachusetts Institute Of Technology

Systems, apparatus, and methods for hearing protection

Systems, apparatus, and methods for filtering acoustic energy include a first conduit substantially aligned with a longitudinal axis and defining a first opening for receiving incident acoustic energy from the environment. A cavity in fluid communication with the first conduit selectively amplifies and/or dampens the acoustic energy based on an associated resonance frequency. ... Massachusetts Institute Of Technology

Flame-retardant, non-toxic phosphate ester ionic liquid electrolytes and method of making

A phosphate ester compound can include a cation and an anion, the anion being an alkyl phosphate. The phosphate ester compound can be a phosphate ester ionic liquid. ... Massachusetts Institute Of Technology

Systems and methods for the synthesis of high thermoelectric performance doped-snte materials

A thermoelectric composition comprising tin (sn), tellurium (te) and at least one dopant that comprises a peak dimensionless figure of merit (zt) of 1.1 and a seebeck coefficient of at least 50 μv/k and a method of manufacturing the thermoelectric composition. A plurality of components are disposed in a ball-milling vessel, wherein the plurality of components comprise tin (sn), tellurium (te), and at least one dopant such as indium (in). ... Massachusetts Institute Of Technology

Synthetic bacteriophages and bacteriophage compositions

Disclosed herein are novel synthetic bacteriophages and bacteriophage compositions, methods of production thereof, and therapeutic uses thereof.. . ... Massachusetts Institute Of Technology

06/07/18 / #20180155400

Compressed pathways for nonribosomal molecular biosynthesis

Provided herein are synthetic pathways from escherichia coli and vibrio cholerae genes for the production of new, synthetic nonribosomal peptides, and methods and compositions comprising the same. Some aspects of the present disclosure are directed to modified bacterial cells comprising a compressed biosynthetic pathway that comprises (a) biosynthetic genes obtained from one species encoding enzymes active in the bioassembly of a nonribosomal molecule, (b) biosynthetic genes obtained from another species encoding enzymes active in the bioassembly of a nonribosomal molecule that is different from the nonribosomal molecule of (a). ... Massachusetts Institute Of Technology

06/07/18 / #20180155283

Dopamine d2 receptor ligands

The present invention relates to novel dopamine d2 receptor ligands. The invention further relates to functionally-biased dopamine d2 receptor ligands and the use of these compounds for treating or preventing central nervous system and systemic disorders associated with dysregulation of dopammode inergic activity. ... Massachusetts Institute Of Technology

06/07/18 / #20180154627

Methods and apparatus for hygromorphic shape control

A composite film includes a substrate that is not responsive to relative humidity, and also one or more layers of hygromorphic material. The hygromorphic material expands in response to an increase in relative humidity and contracts in response to a decrease in relative humidity. ... Massachusetts Institute Of Technology

06/07/18 / #20180154170

Methods and compositions for treating mental disorders and conditions

The invention, in some aspects, relates to methods to alter activity in cells and the use of such method to treat disorders and conditions. The methods involve, in part, expressing stimulus-activated opsin polypeptides in neurons involved in memory and behavior and activating the opsin polypeptides to modulate activity of cells in which they are expressed and/or cells to which the cells that express the opsin polypeptides project.. ... Massachusetts Institute Of Technology

05/31/18 / #20180149639

Modeling neural network dysfunction

The present invention relates to in vitro models of autism and methods of using the same to diagnose disorders associated with network dysfunction, e.g., autism schizophrenia, depression, obsessive-compulsive spectrum disorders, bipolar disorder, or epilepsy, and to identify compounds for use in treating these conditions.. . ... Massachusetts Institute Of Technology

05/31/18 / #20180148729

Engineered bacteria for production and release of therapeutics

Some embodiments described herein relate to cells which have been genetically engineered to release a polypeptide when a population of the cells reaches a desired density. In some embodiments, the released polypeptide may be a therapeutic polypeptide. ... Massachusetts Institute Of Technology

05/31/18 / #20180148364

Methods and apparatus for additive manufacturing of glass

In illustrative implementations of this invention, a crucible kiln heats glass such that the glass becomes or remains molten. A nozzle extrudes the molten glass while one or more actuators actuate movements of the nozzle, a build platform or both. ... Massachusetts Institute Of Technology

05/31/18 / #20180148065

Clutchless shifting of a manual transmission

An apparatus including a drive shaft, a transmission, and a motor shaft. The drive shaft includes a drive gear and is configured to transmit power to a wheel of a vehicle. ... Massachusetts Institute Of Technology

05/31/18 / #20180147826

Methods and apparatus for additive manufacturing with molten glass

A nozzle deposits a filament of viscous, molten glass onto a print bed, while the print bed rotates about a vertical axis and translates in x, y, and z directions. The deposition is computer controlled, such that the resulting deposited filament forms a desired glass object that is solid after it anneals. ... Massachusetts Institute Of Technology

05/31/18 / #20180147798

Methods for fabricating low cost 3-d printed parts with expanded material properties

A 3-d (three dimensional) printing system is provided that includes a customized matrix having suitable material properties and geometric patterning to facilitate filling and retention of one or more filler material. The customized matrix defines the geometry and shape of the object. ... Massachusetts Institute Of Technology

05/24/18 / #20180145110

Distributed nanowire sensor for single photon imaging

An integrated, superconducting imaging sensor may be formed from a single, meandering nanowire. The sensor is capable of single-photon (or single-event) detection and imaging with ˜10 micron spatial resolution and sub-100-picosecond temporal resolution. ... Massachusetts Institute Of Technology

05/24/18 / #20180143295

System and technique for mitigation of clutter in radar

Described are a system and technique to mitigate the impacts of clutter in a radar system. The system and technique require only linear co-polarized measurements can be incorporated into the standard radar signal processing chain without slowing down radar performance.. ... Massachusetts Institute Of Technology

05/24/18 / #20180143125

Device and method for analysing and controlling cell motility

The invention is related to a device and method for analysing and controlling cell motility. In accordance with an aspect of the present invention, there if provided a microfluidic device for analyzing and controlling the motility of a cell, the device comprising: (a) a first inlet for introducing a cell sample; (b) an outlet for discharging the cell sample; (c) a microfluidic channel in fluid communication with and intermediate the first inlet and outlet; (d) a first pump coupled to the first inlet for pumping the cell sample in the microfluidic channel; and (d) an observation area within a portion of the microfluidic channel for analysing and controlling the motility of the cell, wherein the first pump generates a shear stress in the observation area, the shear stress generates a shearotactical signal for driving movement of the cell.. ... Massachusetts Institute Of Technology

05/24/18 / #20180141832

Ion concentration polarization-electrocoagulation hybrid water treatment system

Between two juxtaposed similar ion exchange membranes (aems or cems), an ion depletion zone and ion enrichment zone are generated under an electric field. As cations are selectively transferred through the cems, for example, anions are relocated in order to achieve electro-neutrality, resulting in the concentration drop (increase) in ion depletion (enrichment) zone. ... Massachusetts Institute Of Technology

05/24/18 / #20180141274

Multimaterial 3d-printing with functional fiber

In a method for printing a three dimensional structure, a continuous length of fiber that includes, interior to a surface of the fiber, a plurality of different materials arranged as an in-fiber functional domain, with at least two electrical conductors disposed in the functional domain in electrical contact with at least one functional domain material, is dispensed through a single heated nozzle. After sections of the length of fiber are dispensed from the heated nozzle, the sections are fused together in an arrangement of a three dimensional structure. ... Massachusetts Institute Of Technology

05/24/18 / #20180140625

Production of stable non-polyadenylated rnas

The invention relates in aspects to hybrid rnas lacking a poly-a tail and nucleic acid vectors for expressing the rna. The hybrid rnas in some instances have a stabilizing triple helical structure. ... Massachusetts Institute Of Technology

05/24/18 / #20180140233

High fidelity systems, apparatus, and methods for collecting noise exposure data

Systems, apparatus, and methods for collecting, interpreting, and utilizing noise exposure data may include sensors to obtain an analog signal representative of impulse noise sound pressure and an analog signal representative of continuous noise sound pressure. At least one adc may generate digital signals by sampling the analog signals at rates equal to or greater than twice the reciprocal of a minimum impulse noise rise time. ... Massachusetts Institute Of Technology

05/24/18 / #20180140172

Apparatus, systems, and methods for biomedical imaging and stimulation

A multi-channel optical imaging and stimulation system includes a light source to deliver light beams into a light guide. Different light beams are coupled into different spatial modes supported by the light guide. ... Massachusetts Institute Of Technology

05/17/18 / #20180138751

Wireless non-radiative energy transfer

Described herein are embodiments of a source high-q resonator, optionally coupled to an energy source, a second high-q resonator, optionally coupled to an energy drain that may be located a distance from the source resonator. A third high-q resonator, optionally coupled to an energy drain that may be located a distance from the source resonator. ... Massachusetts Institute Of Technology

05/17/18 / #20180136210

Liquid biopsy detection of leukemia using closed-loop microfluidics

This invention describes a one-step technique for the simultaneous label-free detection and concentration of blast cells from a blood sample. Enrichment of blast cells is achieved using a closed loop microfluidics system, allowing continuous removal of waste and non-target cells to generate concentrated samples of high purity without the need for specific targeting of proteins by antibodies. ... Massachusetts Institute Of Technology

05/17/18 / #20180135970

Systems, apparatus, and methods for spectral imaging

A spectral imaging system includes an autocorrelator to generate different autocorrelations when the moving reflector in the autocorrelator is at different positions so as to reconstruct spectral images. The system also includes a position measurement system to measure the actual positions of the moving reflector when autocorrelations are taken. ... Massachusetts Institute Of Technology

05/17/18 / #20180134945

Nanoparticle-based shear-thickening materials

Compositions including an aqueous colloidal dispersion of a nanomaterial and methods for preparing and using the same are described. The nanomaterial includes, disposed on a surface of the nanomaterial, a first coupling agent including silane and a functional group including an amino acid, and a second coupling agent including silane and a polymer with a molecular weight between 1,000 and 20,000.. ... Massachusetts Institute Of Technology

05/17/18 / #20180133693

Biotemplated perovskite nanomaterials

A biotemplated nanomaterial can include a crystalline perovskite.. . ... Massachusetts Institute Of Technology

05/17/18 / #20180133343

Nanoparticle conjugates and uses thereof

The targeted delivery of therapeutic agents to specific cells remains a challenge in drug delivery. Provided herein are nanoparticle-targeting agent conjugates that can be used for the targeted delivery of therapeutic agents to certain cells and target tissues. ... Massachusetts Institute Of Technology

05/10/18 / #20180131851

Methods and apparatus for optical fiber imaging

An open-ended, incoherent bundle of optical fibers transmits light from a nearby scene. A camera captures images of the back end of the fiber bundle. ... Massachusetts Institute Of Technology

05/10/18 / #20180131720

Dynamic flow system

System and methods for communicating across a network comprise: a database containing high level security rules for the network; computing devices communicating on the network; a security rule translation module; event sensors configured to monitor and detect one or more events occurring on or relating to the network, and in response thereto, provide to the security rule translation module an indication of occurrence for each of the one or more security events. The security rule translation module may associate the security rules with the security events corresponding to the received indication, and produce a low-level security rule based on data from the high-level security rule and the received indication of occurrence of the security events. ... Massachusetts Institute Of Technology

05/10/18 / #20180131311

Highly-efficient near-field thermophotovoltaics using surface-polariton emitters and thin-film photovoltaic-cell absorbers

A near-field thermophotovoltaic system comprises a hot emitter and a cold absorbing photovoltaic cell separated by a small gap. The emitter emits hot photons and includes a polaritonic material that supports a surface-polaritonic mode. ... Massachusetts Institute Of Technology

05/10/18 / #20180128850

Integrated resonant accelerometer using optical strain sensor

An accelerometer may comprise a proof mass, a first tether mechanically coupled to the side of the proof mass and to an anchor, and a ring resonator integrated with the tether to form a sensing tether. The ring resonator and the tether may be configured such that a strain sustained by the sensing tether causes a change of a resonance condition of the ring resonator. ... Massachusetts Institute Of Technology

05/10/18 / #20180128723

Particle isolation/enrichment using continuous closed-loop micro-fluidics

The present invention encompasses a micro-fluidic system having a closed-loop configuration in which inertial micro-fluidic separation of particles and/or cells is continuously repeated by feeding part of the output back to the input so that the purity and/or concentration of the particles and/or cell is maximized. The invention also includes methods of using the micro-fluidic system.. ... Massachusetts Institute Of Technology

05/10/18 / #20180127759

Dynamic genome engineering

Provided herein, in some embodiments, are genomic editing constructs that can achieve nearly 100% recombination efficiency within a select population of bacterial cells.. . ... Massachusetts Institute Of Technology

05/10/18 / #20180127745

Cell sorting

The invention provides for use of crispr-cas systems to sort barcoded cells or molecules. Cells or nucleic acid molecules may be sorted from a heterogenous population by targeting a barcode of interest specific for a cell or cell progeny or nucleic acid molecule of interest.. ... Massachusetts Institute Of Technology

05/10/18 / #20180127447

Metathesis catalysts and methods thereof

The present application provides, among other things, compounds and methods for metathesis reactions. In some embodiments, the present disclosure provides methods for preparing alkenyl halide with regioselectivity and/or stereoselectivity. ... Massachusetts Institute Of Technology

05/10/18 / #20180126677

Extremely compliant yet tough hydrogel systems as ultrasound transmission agents

A method for making a tough and compliant hydrogel. A precursor hydrogel is made of a first polymer selected to maintain high elasticity and a second polymer selected to dissipate mechanical energy. ... Massachusetts Institute Of Technology

05/10/18 / #20180126367

Light-assisted photocatalyst regeneration and oxygen-resilient radical polymerization

A photocatalyst can be regenerated with increasing efficiency, turnover number and turnover frequency in the presence of air by irradiating the photocatalyst with a first range of wavelengths of light that excite the photocatalyst to an intermediate and irradiating the intermediate with a second range of wavelengths of light that turns the intermediate to the photocatalyst.. . ... Massachusetts Institute Of Technology

05/10/18 / #20180126080

Bi-directional motion of a lorentz-force actuated needle-free injector (nfi)

The present invention relate to a method and corresponding apparatus for just in time mixing of a solid or powdered formulation and its subsequent delivery to a biological body. In some embodiments, a powdered formulation is maintained in a first chamber of a plurality of chambers. ... Massachusetts Institute Of Technology

05/10/18 / #20180125391

Systems, apparatus, and methods related to modeling, monitoring, and/or managing metabolism

Systems, apparatus, and methods related to modeling, monitoring, and/or managing metabolism of a subject include measuring a respiratory quotient (rq) level in a subject and/or optimizing and executing a nonlinear feedback model to model energy substrate utilization in the subject based on at least one of a macronutrient composition and caloric value of food consumed by the subject, an intensity and duration of activity by the subject, a rate and maximum capacity of glycogen storage in the subject, a rate and maximum capacity of de novo lipogenesis in the subject, a quality and duration of sleep by the subject, and/or an rq level in the subject.. . ... Massachusetts Institute Of Technology

05/03/18 / #disclosed herein are novel compositions and methods for the treatment of age-related diseases, mitochondrial diseases, the improvement of stress resistance, the improvement of resistance to hypoxia and the extension of life span. also described herein are methods for the identification of agents useful in the foregoing methods.

Massachusetts Institute Of Technology

. . ... Massachusetts Institute Of Technology

05/03/18 / #20180123724

Scheduled light path switching in optical networks and automatic assessment of traffic impairments that would result from adding or deleting a channel in a wavelength-division multiplexed optical communication network

A single-wavelength light path is selected between a source access node and a destination access node of a wavelength-division multiplexed optical network, including selecting an illuminated wavelength of the light path and selecting a start time and duration for a data transfer that would not interfere with other data transfers. If no start time/wavelength combination is available with duration sufficient to transport the data, an additional wavelength is automatically selected, based on modeling, that would not impair traffic being carried by other wavelengths in the network, and without a time-consuming manual process of the prior art. ... Massachusetts Institute Of Technology

05/03/18 / #20180123238

Multipolarized vector sensor array antenna system for search and rescue applications

The present disclosure is directed towards direction finding (df) systems that can detect and locals a radio frequency (rf) signal (e.g. An emergency beacon) is two dimensions (i.e., azimuth and elevation). ... Massachusetts Institute Of Technology

05/03/18 / #20180119219

Augmenting in situ nucleic acid sequencing of expanded biological samples with in vitro sequence information

The invention provides in situ nucleic acid sequencing to be conducted in biological specimens that have been physically expanded. The invention leverages the techniques for expansion microscopy (exm) to provide new methods for in situ sequencing of nucleic acids in a process referred to herein as “expansion sequencing” (exseq).. ... Massachusetts Institute Of Technology

05/03/18 / #20180119141

Crispr/cas global regulator screening platform

Provided herein are methods for identifying genetic networks and methods of treating neurodegenerative disorders associated with α-synuclein dysfunction.. . ... Massachusetts Institute Of Technology

05/03/18 / #20180119089

Microbial system for biosynthesis of natural and engineered products coupled to in situ extraction in supercritical co2

Provided herein are methods of producing a bioproduct by culturing a cell in a multiphase reactor that comprises supercritical co2, near critical co2, or liquid co2.. . ... Massachusetts Institute Of Technology

05/03/18 / #20180118806

Engineered replacement of partial variant water soluble membrane proteins

The present invention is directed to water-soluble membrane proteins, methods for the preparation thereof and methods of use thereof.. . ... Massachusetts Institute Of Technology

05/03/18 / #20180116504

Apparatus and method of determining an eye prescription

Eye prescriptions may be determined by providing a simple, easy to use, portable device with a specially configured targeting light source that aligns the eye, mitigates accommodation, and provides accurate results. Unlike stationary, closed view autorefractors, this device typically is portable, self-usable, relatively inexpensive, enabling more widespread use across the world.. ... Massachusetts Institute Of Technology

04/19/18 / #20180107909

Chemical and physical sensing with a reader and rfid tags

A method of detecting a stimulus can include detecting an output from a radio frequency identification tag including a sensor. A smartphone-based sensing strategy can use chemiresponsive nanomaterials integrated into the circuitry of commercial near field communication tags to achieve non-line-of-sight, portable, and inexpensive detection and discrimination of gas phase chemicals (e.g., ammonia, hydrogen peroxide, cyclohexanone, and water) at part-per-thousand and part-per-million concentrations.. ... Massachusetts Institute Of Technology

04/19/18 / #20180106936

Methods and apparatus for imaging using optical cavity

In illustrative implementations, an imaging system may comprise a lens, an optical cavity and a time-of-flight camera. The imaging system may capture an image of a scene. ... Massachusetts Institute Of Technology

04/19/18 / #20180105806

Method for rna-guided endonuclease-based dna assembly

The invention provides a novel approach to facilitate assembly of dna molecules. This approach utilizes rna-guided endonucleases, capable of targeting any dna sequence, which cleave dna and generate dna fragments characterized by single stranded overhangs. ... Massachusetts Institute Of Technology

04/19/18 / #20180104690

Reaction circuit design in microfluidic circuits

The microfluidic devices and systems disclosed herein reduce sample loss and help decrease sample processing bottlenecks for applications such as next generation sequencing (ngs). The microfluidic devices include a plurality of reaction modules. ... Massachusetts Institute Of Technology

04/12/18 / #the present invention relates to compounds of formula (i):

Massachusetts Institute Of Technology

. . ... Massachusetts Institute Of Technology

04/12/18 / #20180102644

Coupled split path power conversion architecture

Described herein are power conversion systems and related techniques which utilize a coupled split path (csp) circuit architecture. The csp structure combines switches, capacitors and magnetic elements in such a way that power is processed in multiple coupled split paths in a variety of voltage domains. ... Massachusetts Institute Of Technology

04/12/18 / #20180102470

Cryogenic electronic packages and assemblies

A cryogenic electronic package includes a circuitized substrate, an interposer, a superconducting multichip module (smcm) and at least one superconducting semiconductor structure. The at least one superconducting semiconductor structure is disposed over and coupled to the smcm, and the interposer is disposed between the smcm and the substrate. ... Massachusetts Institute Of Technology

04/12/18 / #20180102469

Cryogenic electronic packages and methods for fabricating cryogenic electronic packages

A cryogenic electronic package includes a first superconducting multi-chip module (smcm), a superconducting interposer, a second smcm and a superconducting semiconductor structure. The interposer is disposed over and coupled to the first smcm, the second smcm is disposed over and coupled to the interposer, and the superconducting semiconductor structure is disposed over and coupled to the second smcm. ... Massachusetts Institute Of Technology

04/12/18 / #20180100817

Stable nanocrystalline ordering alloy systems and methods of identifying same

Provided in one embodiment is a method of identifying a stable phase of an ordering binary alloy system comprising a solute element and a solvent element, the method comprising: determining at least three thermodynamic parameters associated with grain boundary segregation, phase separation, and intermetallic compound formation of the ordering binary alloy system; and identifying the stable phase of the ordering binary alloy system based on the first thermodynamic parameter, the second thermodynamic parameter and the third thermodynamic parameter by comparing the first thermodynamic parameter, the second thermodynamic parameter and the third thermodynamic parameter with a predetermined set of respective thermodynamic parameters to identify the stable phase; wherein the stable phase is one of a stable nanocrystalline phase, a metastable nanocrystalline phase, and a non-nanocrystalline phase.. . ... Massachusetts Institute Of Technology

04/05/18 / #20180096482

Devices for refractive field visualization

An apparatus according to an embodiment of the present invention enables measurement and visualization of a refractive field such as a fluid. An embodiment device obtains video captured by a video camera with an imaging plane. ... Massachusetts Institute Of Technology

04/05/18 / #20180095481

Variable thermal resistance

Electrical and electromechanical devices often require maintaining a specific temperature, or a narrow range or temperatures, during operation. An assembly regulates the temperature of a device by providing a variable thermal resistance between the device and a heatsink. ... Massachusetts Institute Of Technology

04/05/18 / #20180094927

Method and apparatus for reducing sensor power dissipation

A sensor produces the sensor data for a sensor data consumer. A facility receives a sensor profile of the sensor indicating a relationship between a sensor parameter operating range and a deviation of the sensor data as a result of scaling one or more sensor parameters. ... Massachusetts Institute Of Technology

04/05/18 / #20180094099

Bottlebrush copolymers and uses thereof

Materials (e.g., particles, hydrogels) that provide extended release of one or more therapeutic agents are useful platforms for drug delivery. In part, the present invention relates to new triblock (abc) bottlebrush copolymers which can be used in the formulation of particles and hydrogels for the extended release of therapeutic agents. ... Massachusetts Institute Of Technology

04/05/18 / #20180093229

Segregation resistant perovskite oxides with surface modification

A method and a composition to stabilize the surface cation chemistry of the perovskite or related oxides, and thus, to minimize or completely avoid the detrimental segregation and phase separation of dopant cations at the surface can include modifying the surface with more oxidizable metal cations and/or more oxidizable metal oxides, thereby reducing the oxygen vacancy concentration at the very surface.. . ... Massachusetts Institute Of Technology

04/05/18 / #20180092538

Systems and methods for dual-mode imaging using optical coherence tomography and fluorescence imaging

Systems and methods are provided to obtain optical coherence tomography data and fluorescence imaging data from an object. The systems and methods use a single light source to illuminate and excite fluorescence in the object and a common optical path including an optical fiber to provide illumination and excitation light and collect reflected and emitted light at the object. ... Massachusetts Institute Of Technology

03/29/18 / #20180090852

Stacked patch antenna array with castellated substrate

Described is a printed circuit antenna array including at least one castellated substrate. Also described is a stacked patch antenna array having at least one castellated substrate.. ... Massachusetts Institute Of Technology

03/29/18 / #20180090283

High-performance supercapacitors based on metal nanowire yarns

An energy-storage device is formed from a first and a second yarn, each yarn including a plurality of nanowires including aluminum and/or a transition metal. An anode pad is in contact with the first yarn and a cathode pad is in contact with the second yarn. ... Massachusetts Institute Of Technology

03/29/18 / #20180086641

Controlled-orientation films and nanocomposites including nanotubes or other nanostructures

Generally, the present invention provides methods for the production of materials comprising a plurality of nanostructures such as nanotubes (e.g., carbon nanotubes) and related articles. The plurality of nanostructures may be provided such that their long axes are substantially aligned and, in some cases, continuous from end to end of the sample. ... Massachusetts Institute Of Technology

03/29/18 / #20180085359

Use of chelators of divalent cations to promote nerve regeneration

Disclosed herein are methods to promote axonal outgrowth of a neuron comprising, contacting the neuron with an effective amount of a chelating agent, to thereby promote axonal outgrowth in the neuron. Also disclosed are methods of treating a subject for a cns lesion, comprising, administering to the subject a therapeutically effective amount of a chelating agent, also disclosed are devices for promoting regeneration in a lesioned neuron, and pharmaceutical compositions comprising a therapeutically effective amount of a chelating agent formulated for localized administration directly to an injured neuron. ... Massachusetts Institute Of Technology

03/22/18 / #20180080927

Systems including janus droplets

Embodiments described herein may be useful in the detection of analytes. The systems and methods may allow for a relatively simple and rapid way for detecting analytes such as chemical and/or biological analytes and may be useful in numerous applications including sensing, food manufacturing, medical diagnostics, performance materials, dynamic lenses, water monitoring, environmental monitoring, detection of proteins, detection of dna, among other applications. ... Massachusetts Institute Of Technology

03/22/18 / #20180080019

Encoding of dna vector identity via iterative hybridization detection of a barcode transcript

Embodiments disclosed herein are directed to a new genetic perturbation and screening method that combines advantages of pooled perturbation with imaging assays for complex phenotypes. Specifically, the method may be used to screen pooled genomic perturbations to identify phenotypes and to identify perturbed genes at the single-cell level using optical barcodes. ... Massachusetts Institute Of Technology

03/22/18 / #20180079786

Constructs for continuous monitoring of live cells

Embodiments disclosed herein provide nucleic acid constructs and methods of use thereof that induce a live cell to give off sub-samples of the cell's cytosolic content. The term “cell” as used herein may be any cell type. ... Massachusetts Institute Of Technology

03/22/18 / #20180079125

Automatic process control of additive manufacturing device

Automatic process control of additive manufacturing. The system includes an additive manufacturing device for making an object and a local network computer controlling the device. ... Massachusetts Institute Of Technology

03/22/18 / #20180078936

Systems, devices, and methods for microfluidics using modular blocks

The present disclosure is directed to the creation and/or manipulation of microfluidic systems and methods that can be formed in pre-existing modular blocks. Microfluidic paths can be formed in one or more blocks, and when multiple blocks are used, the blocks can be used together to form a path across the blocks. ... Massachusetts Institute Of Technology

03/22/18 / #20180078657

Amphiphilic nanoparticles for delivery of crispr based therapy

Disclosed are copolymer micelles for simultaneous delivery of cas9 mrna and guide rna for cas9 crispr gene editing. Also disclosed are copolymer micelles for simultaneous delivery of a therapeutic or diagnostic nucleic acid and a cross-linking or alkylating anticancer agent.. ... Massachusetts Institute Of Technology

03/22/18 / #20180078609

Methods and compositions for treating alzheimer's disease and other memory-associated disorders and conditions

The invention, in part, relates to the use of optogenetic methods to increase dendritic spine density on dg memory engram cells in treatment methods for memory-impairment-associated diseases and conditions.. . ... Massachusetts Institute Of Technology

03/22/18 / #20180078159

Cardiovascular assist system that quantifies heart function and faciltates heart recovery

The systems, devices, and methods presented herein use a heart pump to obtain measurements of cardiovascular function. The heart pumps described herein can operate in parallel with and unload the heart. ... Massachusetts Institute Of Technology

03/15/18 / #20180076003

Method and apparatus for a porous electrospray emitter

An ionic liquid ion source can include a microfabricated body including a base and a tip. The body can be formed of a porous material compatible with at least one of an ionic liquid or room-temperature molten salt. ... Massachusetts Institute Of Technology

03/15/18 / #20180074457

Near-to-eye and see-through holographic displays

A holographic display is comprised of space-multiplexed elemental modulators, each of which consists of a surface acoustic wave transducer atop an anisotropic waveguide. Each “line” of the overall display consists of a single anisotropic waveguide across the display's length with multiple surface acoustic wave transducers spaced along the waveguide length, although for larger displays, the waveguide may be divided into segments, each provided with separate illumination. ... Massachusetts Institute Of Technology

03/15/18 / #20180074383

Electroactive polymer membrane-based active lens assemblies

Active lens assemblies based on a deformable lens adhered to an electroactive polymer (eap) membrane based actuator, active lens systems comprising such active lenses, and methods of actuating a deformable lens are described. The active lenses can provide controllable optical power, withstand constant periods of actuation, have low power consumption, have fewer mechanically moving parts, have fast response times and/or high portability. ... Massachusetts Institute Of Technology

03/15/18 / #20180073031

Transcriptional sensor for bile acids in bacteroides thetaiotaomicron

The present disclosure relates, in some aspects, to bile acid sensors.. . ... Massachusetts Institute Of Technology

03/15/18 / #20180072895

Apparatus and methods employing liquid-impregnated surfaces

In certain embodiments, the invention is directed to apparatus comprising a liquid-impregnated surface, said surface comprising an impregnating liquid and a matrix of solid features spaced sufficiently close to stably contain the impregnating liquid therebetween or therewithin, and methods thereof. In some embodiments, one or both of the following holds: (i) 0<φ≦0.25, where φ is a representative fraction of the projected surface area of the liquid-impregnated surface corresponding to non-submerged solid at equilibrium; and (ii) sow(a)<0, where sow(a) is spreading coefficient, defined as γwa−γwo−γoa, where γ is the interfacial tension between the two phases designated by subscripts w, a, and o, where w is water, a is air, and o is the impregnating liquid.. ... Massachusetts Institute Of Technology

03/15/18 / #20180072327

Systems and methods for using an attention buffer to improve resource allocation management

Systems and methods for assessing resource allocation are provided. In some exemplary embodiments, the system uses an attention buffer to classify glances by a person and/or automated system, the buffer determining the impact the glances have on the person and/or automated system's situation awareness level. ... Massachusetts Institute Of Technology

03/15/18 / #20180071738

Massively parallel on-chip coalescence of microemulsions

Embodiments disclosed herein are directed to microfluidic devices that allow for scalable on-chip screening of combinatorial libraries and methods of use thereof. Droplets comprising individual molecular species to be screened are loaded onto the microfluidic device. ... Massachusetts Institute Of Technology

03/15/18 / #20180071215

Core-shell particles for controlled release

Compositions, methods, and systems for controlling crystallization of an agent are generally described. In some embodiments, an agent is crystallized in the presence of polymer matrices, such as polymer particles. ... Massachusetts Institute Of Technology

03/08/18 / #20180068062

Methods for identifying novel gene editing elements

Embodiments disclosed herein provide methods for identifying new crispr loci and effectors, as well as different crispr loci combinations found in various organisms. Class-ii crispr systems contain single-gene effectors that have been engineered for transformative biological discovery and biomedical applications. ... Massachusetts Institute Of Technology

03/08/18 / #20180067065

Ethylene sensor

A sensor device can include a transition metal complex capable of interacting with a carbon-carbon multiple bond moiety. The sensor can detect the fruit-ripening hormone ethylene with high sensitivity.. ... Massachusetts Institute Of Technology

03/08/18 / #20180066242

Crispr-cas systems and methods for altering expression of gene products, structural information and inducible modular cas enzymes

The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are structural information on the cas protein of the crispr-cas system, use of this information in generating modified components of the crispr complex, vectors and vector systems which encode one or more components or modified components of a crispr complex, as well as methods for the design and use of such vectors and components. ... Massachusetts Institute Of Technology

03/08/18 / #20180066012

Solid phase peptide synthesis processes and associated systems

Systems and processes for performing solid phase peptide synthesis are generally described. Solid phase peptide synthesis is a known process in which amino acid residues are added to peptides that have been immobilized on a solid support. ... Massachusetts Institute Of Technology

03/01/18 / #20180062163

Lithium hydrogen titanate li-h-ti-o material and method for making the same

A lithium hydrogen titanate li—h—ti—o material includes li, h, ti, and o elements, wherein a mass percentage of li is in a range from about 3% to about 12%, a mass percentage of h is in a range from about 0.1% to about 8%, a mass percentage of ti is in a range from about 46% to about 56%, and a mass percentage of o is in a range from about 28% to about 50%. A lithium ion battery and a method for making the lithium hydrogen titanate li—h—ti—o material are also disclosed.. ... Massachusetts Institute Of Technology

03/01/18 / #20180061063

Methods and devices for measuring object motion using camera images

A method and corresponding apparatus for measuring object motion using camera images may include measuring a global optical flow field of a scene. The scene may include target and reference objects captured in an image sequence. ... Massachusetts Institute Of Technology

03/01/18 / #20180059086

Substrate containing latent vaporization reagents

Methods and reagents are disclosed for improved detection of inorganic oxidizers, such as but not limited to chlorates, perchlorates, permanganates, dichromates, and osmium tetraoxides. In one aspect of the invention, latent acid-generating reagents are employed that are chemically stable at room temperature but undergo an acidic transformation when exposed to an elevated temperature or radiation. ... Massachusetts Institute Of Technology

03/01/18 / #20180057525

Solid phase peptide synthesis processes and associated systems

Systems and processes for performing solid phase peptide synthesis are generally described. Solid phase peptide synthesis is a known process in which amino acid residues are added to peptides that have been immobilized on a solid support. ... Massachusetts Institute Of Technology

03/01/18 / #20180057443

Mechanochemical synthesis of iptycenes

Methods for mechanochemically synthesizing compositions comprising bridged bicyclic-based compounds such as iptycene-based compounds are generally provided. In some cases, two or more polycyclic aromatic hydrocarbons may be mechanochemically reacted such that the product comprises the bridged bicyclic-based compound. ... Massachusetts Institute Of Technology

03/01/18 / #20180056582

Systems, devices, and methods for inkjet-based three-dimensional printing

Devices and methods are described that provide printing of three-dimensional objects using reactive materials such as materials that result in a polyurethane formulation. Three-dimensional printing in accordance with the present disclosure can be performed using an inkjet printer or other systems that deposit or dispense material. ... Massachusetts Institute Of Technology

02/22/18 / #20180053934

High-capacity positive electrode active material

This disclosure provides a positive electrode active lithium-excess metal oxide with composition lixmyo2 (0.6≦y≦0.85 and 0≦x+y≦2) for a lithium secondary battery with a high reversible capacity that is insensitive with respect to cation-disorder. The material exhibits a high capacity without the requirement of overcharge during the first cycles.. ... Massachusetts Institute Of Technology

02/22/18 / #20180053103

Systems and methods for providing visual allocation management

Systems and methods for managing visual allocation are provided herein that use models to determine states based on visual data and, based thereon, output feedback based on the determined states. Visual data is initially obtained by a visual allocation management system. ... Massachusetts Institute Of Technology

02/22/18 / #20180051319

High-throughput drug and genetic assays for cellular transformation

A method for detecting oncogenic growth and viability, and/or degree of cellular transformation and/or identifying an agent that inhibits cellular transformation is disclosed. The method including: providing a cellular sample, such as a sample of cells obtained from a subject or a cell line; culturing the cellular sample in low attachment conditions; and detecting growth and7or cell viability of the sample, wherein increased growth relative and/or viability relative to a control or control level indicative of basal growth and/or viability indicates cellular transformation. ... Massachusetts Institute Of Technology

02/22/18 / #20180050133

Medical devices and implements with liquid-impregnated surfaces

Described herein are medical devices and medical implements with high lubricity to flesh (or biological fluid) and/or inhibited nucleation on its surface. The device has a surface comprising an impregnating liquid and a plurality of micro-scale and/or nano-scale solid features spaced sufficiently close to stably contain the impregnating liquid therebetween. ... Massachusetts Institute Of Technology

02/22/18 / #20180049765

Tissue collection needle

A tissue collection needle with a hollow interior provides two opposing tips with beveled edges on facets that drive tissue toward the hollow interior where the tissue can be gathered and severed from surrounding tissue as the needle advances through a biological specimen. The points and bevels are advantageously formed from a minimal number of cuts amenable to rapid fabrication from readily available hollow needle stock.. ... Massachusetts Institute Of Technology

02/22/18 / #20180049636

Dynamic display system and method for customizing a controller in a display system

A method, or corresponding dynamic display system, for customizing a controller of a display system includes presenting a visual stimulus to a subject at at least one known location relative to the subject's eye gaze; measuring brain activity of the subject's left and right brain hemispheres in response to the subject's viewing of the stimulus; processing the measured brain activity to determine a frequency-dependent metric of the measured brain activity; assessing independent cognitive capacities of the subject's left and right brain hemispheres based on the frequency-dependent metric; and adjusting a function of the controller in the display system according to the assessed independent capacities, such as by adjusting the function to change a stimulus load in a visual hemifield according to the brain activity in the contralateral brain hemisphere. Example applications include head-up display (hud), augmented reality (ar) or virtual reality (vr) display systems, and brain injury assessment systems.. ... Massachusetts Institute Of Technology

02/15/18 / #20180048340

Equalization of receiver

Methods and systems for equalization of a first receiver. A method may include receiving an input signal at the first receiver. ... Massachusetts Institute Of Technology

02/15/18 / #20180048061

Foam radiator

A novel system and method for creating a lightweight antenna is disclosed. Each lightweight antenna is formed using a foam material. ... Massachusetts Institute Of Technology

02/15/18 / #20180046721

Systems and methods for automatic customization of content filtering

Exemplary embodiments include a system and method for automatic customization of content filtering (accf). The method includes receiving a search string from a user, creating a first filter based on the search string and searching different types of content stored in different content locations based on the first filter. ... Massachusetts Institute Of Technology

02/15/18 / #20180046585

Timely address space randomization

A method for timely address space randomize includes loading a code region from a program binary to a first location within the address space, detecting, during execution of the program, an output-input call pair from the program and, in response to detecting the output-input call pair from the program: selecting a second location within the address space to move the code region to, determining memory locations of one or more references to the code region, updating the values of the references in memory based on the second location and using annotation information within the program binary, and moving the code region to the second location within the address space.. . ... Massachusetts Institute Of Technology

02/15/18 / #20180044662

Use and production of chd8+/- transgenic animals with behavioral phenotypes characteristic of autism spectrum disorder

The invention involves inducing a plurality e.g., 3-50 or more mutations (e.g., any whole number between 3 and 50 or more of mutations, with it noted that in some embodiments there can be up to 16 different rna(s), e.g., sgrnas each having its own a promoter, in a vector, such an aav vector or a lentiviral vector and that when each sgrna does not have its own promoter, there can be twice to thrice that amount of different rna(s), e.g., sgrnas, e.g., 32 or even 48 different guides delivered by one vector) in transgenic cas9 eukaryotes to model a neuronal disease or disorder. The invention comprehends testing putative treatments with such models, e.g., testing putative chemical compounds that may be pharmaceutically relevant for treatment or gene therapy that may be relevant for treatment, or combinations thereof. ... Massachusetts Institute Of Technology

02/15/18 / #20180042483

Systems and methods for hyperspectral imaging

A method, and corresponding system, can include identifying a plurality of wavelength spectral band components in hyperspectral image data, the spectral band components corresponding to mutually distinct sources of image contrast. An intensity image corresponding to each respective spectral band component can be calculated, followed by combining the respective intensity images to form an inter-band image based on the respective, mutually distinct sources of image contrast for each spectral band component. ... Massachusetts Institute Of Technology

02/08/18 / #20180040749

Semiconductor nanocrystals

A semiconductor nanocrystal include a first semiconductor material and have a luminescence quantum yield of at least 10%, at least 20%, or at least 30%. The nanocrystal can be substantially free of toxic elements. ... Massachusetts Institute Of Technology

02/08/18 / #20180040663

Photodiode array structure for cross talk suppression

There is provided an avalanche photodiode array that includes a plurality of avalanche photodiodes. Each avalanche photodiode in the array includes a stack of active photodiode materials. ... Massachusetts Institute Of Technology

02/08/18 / #20180039859

Joint acoustic and visual processing

An approach to joint acoustic and visual processing associates images with corresponding audio signals, for example, for the retrievals of images according to voice queries. A set of paired images and audio signals are processed without requiring transcription, segmentation, or annotation of either the images or the audio. ... Massachusetts Institute Of Technology

02/08/18 / #20180039036

Thermally-drawn fiber including devices

There is provided herein a fiber including a fiber body with a fiber body material having a longitudinal axis along a fiber body length. A plurality of devices is disposed as a linear sequence of devices within the fiber body. ... Massachusetts Institute Of Technology

02/01/18 / #20180034031

Lithium-air battery separators and related compositions

Battery separators for lithium-air batteries are provided. In some embodiments, a lithium-air battery may comprise one or more electrochemical cells including an anode, a cathode, an electrolyte, and a battery separator positioned between the anode and the cathode. ... Massachusetts Institute Of Technology

02/01/18 / #20180032838

Deviation magnification: revealing departures from ideal geometries

Geometries of the structures and objects deviate from their idealized models, while not always visible to the naked eye. Embodiments of the present invention reveal and visualize such subtle geometric deviations, which can contain useful, surprising information. ... Massachusetts Institute Of Technology

02/01/18 / #20180032039

Controlling dynamical systems with bounded probability of failure

A computer-based method controls a dynamical system in an uncertain environment within a bounded probability of failure. The dynamical system has a state space and a control space. ... Massachusetts Institute Of Technology

02/01/18 / #20180030213

Block co-poly(metal organic nanostructures) (bcpmons) and uses thereof

The present disclosure provides (block co-polymer)-(metal organic framework) conjugates (bcpmofs), such as (block co-polymer)-(metal organic nanostructure) conjugates (bcpmons), and thermoplastic elastomers, gels, and compositions thereof. Exemplary bcpmons include (block co-polymer)-(metal organic cage) conjugates (bcpmocs), (block co-polymer)-(metal organic paddlewheel) conjugates, and (block co-polymer)-(metal organic square) conjugates, such as bcpmons of formula (a), (b), or (c). ... Massachusetts Institute Of Technology

02/01/18 / #20180028962

Systems and methods incorporating ionic liquids for electrochemically mediated capturing of lewis acid gases

The present invention generally relates to methods and systems for capturing a lewis acid gas (e.g., co2). In some embodiments, the methods and systems utilize an ionic liquid incorporated into one or more electrochemical cells.. ... Massachusetts Institute Of Technology

01/25/18 / #20180026801

Waveguide with dielectric light reflectors

An improved waveguide is disclosed. The waveguide comprises four or five layers, an inner core polymer, one or two layers of outer cladding polymer either on one side of the core of sandwiching the inner core polymer, and two layers of a dielectric reflector sandwiching the outer cladding polymer. ... Massachusetts Institute Of Technology

01/25/18 / #20180025182

Phosphor-loaded waveguide

An improved waveguide is disclosed. The waveguide utilizes a luminescent material disposed within or around its perimeter to introduce additional light into the waveguide. ... Massachusetts Institute Of Technology

01/25/18 / #20180025110

Analyzing characteristics of genomic regions of a genome

Embodiments of techniques for analyzing one or more genomic regions of a genome of an organism. Data about a genomic region may be analyzed to determine an information content of the genomic region, which may indicate an amount of information provided by the genomic region. ... Massachusetts Institute Of Technology

01/25/18 / #20180021455

Receptor-targeted nanoparticles for enhanced transcytosis mediated drug delivery

Receptor-targeted nanoparticles (r-nps) are provided for selective transport into and through targeted tissues of therapeutic, prophylactic and diagnostic agents. R-nps can include polymeric particle, lipid particles, inorganic particles, or a combination thereof with a targeting moiety selective for binding to a receptor on the cells where the agent is to be delivered, where the receptor mediates transcytosis of the nanoparticle into and through the cells. ... Massachusetts Institute Of Technology

01/25/18 / #20180021260

Artificial cell constructs for cellular manipulation

The present invention contemplates induction of immunological tolerance thereby providing permanent allograft acceptance. This method obviates the need for a lifelong regimen of immunosuppressive agents which can increase the risk of infection, autoimmunity, and cancer. ... Massachusetts Institute Of Technology

01/25/18 / #20180020948

Rf attenuation measurement system and method

In part, disclosure relates to a monitoring system for monitoring rf attenuation of a material. In one embodiment, the system includes a plurality of transmitting antennas; an rf generator having a first output terminal in electrical communication with each of the plurality of transmitting antennas and a second output terminal; a plurality of receiving antennas, each of the receiving antennas having an output terminal, and a processor having a first input terminal in electrical communication with the second output terminal of the rf generator, having a second input terminal in electrical communication with the output terminal of each of the plurality of receiving antennas, and having a first output in electrical communication with a display. ... Massachusetts Institute Of Technology

01/18/18 / #20180019421

Transparent photovoltaic cells

A transparent photovoltaic cell and method of making are disclosed. The photovoltaic cell may include a transparent substrate and a first active material overlying the substrate. ... Massachusetts Institute Of Technology

01/18/18 / #20180016998

Fuel management system for variable ethanol octane enhancement of gasoline engines

Fuel management system for efficient operation of a spark ignition gasoline engine. Injectors inject an anti-knock agent such as ethanol directly into a cylinder of the engine. ... Massachusetts Institute Of Technology

01/18/18 / #20180016539

Disruption and field enabled delivery of compounds and compositions into cells

A microfluidic system for causing perturbations in a cell membrane includes (a) a microfluidic channel defining a lumen and configured such that a cell suspended in a buffer can pass there through, and (b) source or emitter of an energy field. The microfluidic channel may include a cell-deforming constriction. ... Massachusetts Institute Of Technology

01/18/18 / #20180015296

Optogenetic control of endothelial cells

The invention features methods for regulating vascular properties by controlling the membrane properties of endothelial cells using optogenetics and light. The invention features methods to transport therapeutics across the vascular barrier into tissues such as the brain and the lung, with high spatial and temporal precision, and for controlling vascular properties such as vascular tone, arterial diameter, and vascular growth.. ... Massachusetts Institute Of Technology

01/18/18 / #20180015174

Synthetic nanoparticles for delivery of immunomodulatory compounds

The present disclosure provides a synthetic nanoparticle comprising a peptide nucleic acid (pna) oligomer conjugated to a lipid, wherein the pna oligomer noncovalently complexes with an immunomodulatory compound, thereby forming a nanoparticle. The nanoparticles are useful to elicit immune responses and can be used to treat a broad range of cancers and infectious diseases.. ... Massachusetts Institute Of Technology

01/18/18 / #20180015167

Crosslinkable trehalose for the covalent incorporation in hydrogels and methods of use

Methods of controlled delivery of bioactive therapeutics are provided. Compositions comprising therapeutic implants are provided.. ... Massachusetts Institute Of Technology

01/11/18 / #20180013052

Qubit and coupler circuit structures and coupling techniques

Quantum bit (qubit) circuits, coupler circuit structures and coupling techniques are described. Such circuits and techniques may be used to provide multi-qubit circuits suitable for use in multichip modules (mcms).. ... Massachusetts Institute Of Technology

01/11/18 / #20180012932

Interconnect structures for assembly of semiconductor structures including superconducting integrated circuits

A multi-layer semiconductor structure includes a first semiconductor structure and a second semiconductor structure, with at least one of the first and second semiconductor structures provided as a superconducting semiconductor structure. The multi-layer semiconductor structure also includes one or more interconnect structures. ... Massachusetts Institute Of Technology

01/11/18 / #20180012014

Systems and methods evaluating password complexity and strength

A password evaluation engine used to evaluate a user's password that redefines the concepts of password complexity and password strength is discussed. Password complexity may be calculated by the evaluation engine so as to take into account the amount of knowledge possessed by a potential attacker, seeking to crack the password, of the rules corresponding to a rule set used for generating the password. ... Massachusetts Institute Of Technology

01/11/18 / #20180011072

Systems and methods related to optical nanosensors comprising photoluminescent nanostructures

Systems and methods related to optical nanosensors comprising photoluminescent nanostructures are generally described.. . ... Massachusetts Institute Of Technology

01/11/18 / #20180010969

Directional force sensing element and system

A directional force sensor and sensing system are described. The directional force sensor includes a leaf spring and one or more load sensors disposed about the leaf spring such that in response to a force applied to the leaf spring, the one or more load sensors provide a signal. ... Massachusetts Institute Of Technology

01/11/18 / #20180010911

Ground-based system for geolocation of perpetrators of aircraft laser strikes

Laser light source geolocation. The system includes two spaced-apart ground based sensors for receiving light from a laser source that has been off-axis scattered by air molecules and particulates to form scattered light imagery. ... Massachusetts Institute Of Technology

01/11/18 / #20180010621

Methods and apparatus for shape control

In exemplary implementations of this invention, a shape controller controls the shape of a bladder as the bladder inflates. The shape controller includes a first set of regions and a second set of regions. ... Massachusetts Institute Of Technology

01/11/18 / #20180010134

Delivery, use and therapeutic applications of the crispr-cas systems and compositions for modeling competition fo multiple cancer mutations in vivo

The invention involves inducing 3-50 or more mutations (e.g., any whole number between 3 and 50 of mutations, with it noted that in some embodiments there can be up to 16 different rna(s), e.g., sgrnas each having its own a promoter, in a vector, such as aav, and that when each sgrna does not have its own promoter, there can be twice to thrice that amount of different rna(s), e.g., sgrnas, e.g., 32 or even 48 different guides delivered by one vector) in transgenic cas9 eukaryotes to model genetic disease, e.g. Cancer. ... Massachusetts Institute Of Technology

01/11/18 / #20180010091

Hydrogel comprising a scaffold macromer crosslinked with a peptide and a recognition motif

Methods of forming, dissolving, and functionalizing an extracellular matrix gel on demand based on cross-linking, modification, and dissolution of hydrogels using transpeptidase (e.g. Sortase) are disclosed. ... Massachusetts Institute Of Technology

01/11/18 / #20180009850

Influenza treatment and/or characterization, human-adapted ha polypeptides; vaccines

The present invention provides, among other things, methods, reagents, and systems for the treatment, detection, analysis, and/or characterization of influenza infections.. . ... Massachusetts Institute Of Technology

01/11/18 / #20180009110

Discrete assemblers utilizing conventional motion systems

An alternative to additive manufacturing is disclosed, introducing an end-to-end workflow in which discrete building blocks are reversibly joined to produce assemblies called digital materials. Described is the design of the bulk-material building blocks and the devices that are assembled from them. ... Massachusetts Institute Of Technology

01/11/18 / #20180009001

Methods for the vapor phase deposition of polymer thin films

Disclosed are methods for forming thin polymeric films on a surface of an article by deposition from the vapor phase. In certain embodiments, the method comprises depositing the polymeric film in situ inside a space or enclosure contained within the article. ... Massachusetts Institute Of Technology

01/11/18 / #20180008687

Nanoparticle conjugates of highly potent toxins and intraperitoneal administration of nanoparticles for treating or imaging cancer

Disclosed are methods of treating cancer of the intraperitoneal cavity using compositions comprising nanoparticles without targeting agents. In addition, nanoparticles are described that comprise a highly toxic anticancer agent (e.g., an anticancer agent having an ic50 less than 1 nm) covalently bound via a linker to a triblock copolymer. ... Massachusetts Institute Of Technology

01/04/18 / #20180007264

Imaging system for immersive surveillance

Security guards at big facilities, such as airports, monitor multiple screens that display images from individual surveillance cameras dispersed throughout the facility. If a guard zooms with a particular camera, he will lose image resolution, along with perspective on the surrounding area. ... Massachusetts Institute Of Technology








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