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Mayo Foundation For Medical Education And Research
Mayo Foundation For Medical Education And Research A Minnesota Corporation
Mayo Foundation For Medical Education And Research A Corporation
Mayo Foundation For Medical Education And Research A Charitable Corporation Of Minnesota
Mayo Foundation For Medical Education And Research Acorda Therapeutics Inc
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Mayo Foundation For Medical Education And Research patents


Recent patent applications related to Mayo Foundation For Medical Education And Research. Mayo Foundation For Medical Education And Research is listed as an Agent/Assignee. Note: Mayo Foundation For Medical Education And Research may have other listings under different names/spellings. We're not affiliated with Mayo Foundation For Medical Education And Research, we're just tracking patents.

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Methods for cell labeling and medical imaging

Methods of ex vivo labeling of a biological material for in vivo imaging, methods of labeling a biological material in vivo, methods for preparing a labeling agent, and methods for in vivo imaging of a subject using a biological material labeled with a labeling agent are disclosed. In one non-limiting... Mayo Foundation For Medical Education And Research

Compounds for modulating mitochondrial function

Compounds and compositions that can modulate mitochondrial function in neuronal cells are provided herein, as are methods for using the compounds and compositions to treat or prevent conditions such as Alzheimer's disease.... Mayo Foundation For Medical Education And Research

Methods and materials for treating human immunodeficiency virus infections

This document provides methods and materials for treating HIV infections. For example, methods and materials for using one or more proteosome inhibitors in combination with one or more other agents to treat HIV infections are provided.... Mayo Foundation For Medical Education And Research

Detecting esophageal disorders

Provided herein is technology for esophageal disorder screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of esophageal disorders (e.g., Barrett's esophagus, Barrett's esophageal dysplasia, etc.). In addition, the technology provides methods, compositions and related uses for distinguishing between Barrett's esophagus and Barrett's... Mayo Foundation For Medical Education And Research

Methods for optimizing imaging technique parameters for photon-counting computed tomography

Described here are systems and methods for optimization techniques for automatically selecting x-ray beam spectra, energy threshold, energy bin settings, and other imaging technique parameters for photon-counting detector computed tomography (“PCCT”). The techniques described here are generally based on subject or object size, material of interest, and location of the... Mayo Foundation For Medical Education And Research

Dissolvable dilator

Devices and methods can be used for the dilation of body conduits. For example, this document provides devices and methods for dilating a ureter using a dissolvable dilator element that is compatible with an ureteroscope system. Such a dissolvable dilator can be advanced into a patient's ureter via the urologic... Mayo Foundation For Medical Education And Research

Speech intelligibility enhancement system

A speech intelligibility system. Embodiments comprise a talker unit, a listener unit and an earpiece. The talker unit includes a microphone to receive audible speech content and to produce electrical signals representative of the speech content, and a transmitter coupled to the microphone to produce wireless transmissions containing the speech... Mayo Foundation For Medical Education And Research

Methods and materials for assessing chemotherapy responsiveness and treating cancer

This document provides methods and materials involved in assessing chemotherapy responsiveness and treating cancer (e.g., breast cancer). For example, methods and materials for determining whether or not a cancer patient (e.g., a breast cancer patient) is likely to respond to chemotherapy (e.g., a taxane therapy) based at least in part... Mayo Foundation For Medical Education And Research

Prevotella histicola preparations and the treatment of autoimmune conditions

This document provides methods and materials related to Prevotella histicola preparations. For example, Prevotella histicola preparations in the form of an oral medicament or dietary supplement (e.g., a pill, tablet, capsule) are provided. In addition, methods and materials for using a Prevotella histicola preparation provided herein as an anti-inflammatory agent... Mayo Foundation For Medical Education And Research

Traction apparatuses and spinal traction systems

Traction apparatuses can be used to facilitate spinal surgery. For example, this document provides traction apparatuses that engage with the skull of a patient, traction apparatuses that engage with the pelvis of a patient, and cervical traction systems for use in conjunction with the skull and/or pelvis traction apparatuses to... Mayo Foundation For Medical Education And Research

Methods of treating neurological inflammatory disorders

Methods of treating neurological inflammatory disease or seizures caused by neuroinflammation by administering cPMP are described. Treating neuroinflammatory and neurometabolic diseases with cPMP is described so as to override dyshomeostasis in the MoCo synthesis pathway and control synaptic inhibition in the gephyrin-GABAR pathway. This is a novel strategy for preventing... Mayo Foundation For Medical Education And Research

Methods and materials for assessing and treating arthritis

This document provides methods and materials involved in assessing mammals (e.g., humans) for arthritis. For example, methods and materials for assessing a mammal's gut microbial diversity to identify the mammal as having arthritis (e.g., rheumatoid arthritis) are provided. This document also provides methods and materials involved in treating arthritis.... Mayo Foundation For Medical Education And Research

Estimating abdominal aortic aneurysm (aaa) expansion rate using clinical and genetic data

The present invention relates to methods of identifying and using risk factors for estimating aneurysm expansion, including high risk expansion in abdominal aortic aneurysm patients, such factors including associated genetic variants and gender differences. In particular, methods of using genetic risk scores and/or patient genotypes are provided for use, including... Mayo Foundation For Medical Education And Research

Pyrazole derivatives as inhibitors of stat3

Compositions that modulate the activity of signal transducer and activator of transcription-3 (STAT3) activity as well as their methods of use, such as treatment and imaging are provided. Compositions contain small molecules such as substituted pyrazoles and are useful in treatment of diseases related to the activity of STAT3 including,... Mayo Foundation For Medical Education And Research

Early marker of proteinuria in patients treated with an anti-vegf treatment

This document provides methods and materials related to determining whether or not a human receiving a therapy (e.g., an anti-VEGF therapy such as a bevacizumab therapy) has developed or is at risk for developing proteinuria. For example, methods and materials for detecting urinary podocytes to determine whether or not a... Mayo Foundation For Medical Education And Research

Methods and materials for assembling nucleic acid constructs

This document provides methods and materials for assembling nucleic acid constructs (e.g., TALENs). For example, methods for assembling TALEs that are rapid, flexible for use in many cloning scaffolds (such as common nuclease and nickase backbones), and achievable with standard molecular biology laboratory tools, thereby making TALEs a more accessible... Mayo Foundation For Medical Education And Research

Methods and materials for reducing the risk of infections

This document relates to methods and materials for reducing the risk of infection after a shoulder surgery or medical procedure. For example, this document relates to methods and materials for using a topical composition containing clindamycin or erythromycin to reduce the risk of or to prevent infection associated with shoulder... Mayo Foundation For Medical Education And Research

Co2-sensing chest tube and needle thoracostomy devices

This document provides systems and methods that can improve the efficacy of tube and needle thoracostomy. For example, this document provides devices and methods for confirming the proper placement of a chest tube or needle within the pleural space to relieve a pneumothorax or tension pneumothoax.... Mayo Foundation For Medical Education And Research

Tube thoracostomy using an optical trocar

Systems and methods that can improve the safety and efficacy of chest tube thoracostomy are described. For example, this document provides systems and methods that facilitate direct visual confirmation of the proper placement of a chest tube within the thoracic space.... Mayo Foundation For Medical Education And Research

Methods and materials for reducing cardiac xenograft rejection

This document provides methods and materials involved in reducing cardiac xenograft rejection. For example, methods and materials for preparing transgenic pigs expressing reduced or no endogenous Sda or SDa-like glycans derived from the porcine β1,4 N-acetyl-galactosaminyl transferase 2 (B4GALNT2) glycosyltransferase and/or reduced or no endogenous α-Gal antigens, methods and materials... Mayo Foundation For Medical Education And Research

Methods and materials for treating cancer

This document provides methods and materials for treating cancers including renal cancer (e.g., renal cell carcinoma) as well as ovarian, breast, prostate, colon, pancreatic, bladder, liver, lung, and thyroid cancers and melanoma. For example, methods and material for using one or more inhibitors of an SCD1 polypeptide to treat renal... Mayo Foundation For Medical Education And Research

Soluble b7-h1

This document features methods of evaluating mammals by assessing expression of B7-H1 in a body fluid.... Mayo Foundation For Medical Education And Research

Treatment of neonatal hypoxia including impairments or effects thereof

The invention provides methods for the treatment of neonatal hypoxia and associated white matter disease or injury, particularly in infant, including neonatal, animals, particularly Periventricular Leukomalacia (PVL) comprising administering one or more CNS reactive antibody, particularly selected from IgM12, IgM22, IgM42 and IgM46. Compositions for use in treatment of white... Mayo Foundation For Medical Education And Research

Joint fusion instrumentation and methods

Systems and methods for joint preparation and fusion are disclosed. The system includes a cutting device having a handle, and rigid blade member. The blade member may include cutting edges on first and second sides, and may be curved in one or more planes. The blade member may be deployed... Mayo Foundation For Medical Education And Research

Prostacyclin compositions for regulation of fracture repair and bone formation

The present disclosure provides a prostacyclin coated implant to enhance fracture repair and bone formation comprising: an implant; and a prostacyclin coating comprising a prostacyclin compound disposed in a polymer coating the implant, wherein the prostacyclin coating releases the prostacyclin compound which enhances fracture repair and bone formation.... Mayo Foundation For Medical Education And Research

Methods and compositions for killing senescent cells and for treating senescence-associated diseases and disorders

Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic... Mayo Foundation For Medical Education And Research

Hla-dr binding peptides and their uses

The present invention provides HLA-DR (MHC class II) binding peptides derived from the ovarian/breast cancer associated antigens, Human Epidermal Growth Factor Receptor 2 (HER-2/neu), Carcinoembryonic Antigen (CEA), Insulin Growth Factor Binding Protein 2 (IGFBP-2), and Cyclin D1. The immunogenic peptides can be used in cancer vaccines.... Mayo Foundation For Medical Education And Research

Method for ultrasound elastography through continuous vibration of an ultrasound transducer

A method for imaging an object by ultrasound elastography through continuous vibration of the ultrasound transducer is taught. An actuator directly in contact with the ultrasound transducer continuously vibrates the transducer in an axial direction, inducing shear waves in the tissue and allowing for real-time shear wave imaging. Axial motion... Mayo Foundation For Medical Education And Research

Methods and materials for reducing cysts and kidney weight in mammals with polycystic kidney disease

This document provides methods and materials for using natriuretic polypeptides to reduce the generation of kidney cysts, to reduce the number of kidney cysts, to reduce the size of kidney cysts, and/or to reduce the weight of a mammal's kidneys in mammals with polycystic kidney disease. For example, methods and... Mayo Foundation For Medical Education And Research

Detection of lung neoplasia by analysis of methylated dna

Provided herein is technology for lung neoplasia screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of lung cancer.... Mayo Foundation For Medical Education And Research

Imaging data capture and video streaming system

Systems and methods of the present invention provide for one or more server computers communicatively coupled to a network and configured to: receive an imaging data from a medical imaging device; encode a digital video data stream from the video data; transmit the digital video data stream via a wireless... Mayo Foundation For Medical Education And Research

Medical reservoir level sensor

Devices can be used to detect a level of a fluid in a medical fluid reservoir. Methods for controlling the flow rate of a medical pump, and/or the occlusion amount of a medical fluid tube, that are based on the detected level of fluid in the medical reservoir can be... Mayo Foundation For Medical Education And Research

System and improved energy series of images using multi-energy ct

A method for creating an energy series of images acquired using a multi-energy computed tomography (CT) imaging system having a plurality of energy bins includes acquiring, with the multi-energy CT imaging system, a series of energy data sets, where each energy data set is associated with at least one of... Mayo Foundation For Medical Education And Research

Double cuff tracheostomy device

This document provides devices and methods for performing tracheostomies. For example, this document provides devices and methods for performing tracheostomies using tracheostomy tubes that include a cuff at the neck opening area that can prevent or reduce the potential for air leaks.... Mayo Foundation For Medical Education And Research

Spectrometric systems and mechanical methods for improved focus localization of time and space-varying measurements

A system and method of dynamically localizing a measurement of parameter characterizing tissue sample with waves produced by spectrometric system at multiple wavelengths and detected at a fixed location of the detector of the system. The parameter is calculated based on impulse response of the sample, reference data representing characteristics... Mayo Foundation For Medical Education And Research

11/02/17 / #20170311899

Apparatus and identifying movement in a patient

Methods for operating a processing system to generate accurate information representative of movement of a body from activity sensors such as tri-axial accelerometers. The system uses wavelet analysis and/or adaptive thresholds to provide quantitative measurements of a person's posture and/or activity, including low-speed activity, during daily living.... Mayo Foundation For Medical Education And Research

11/02/17 / #20170311952

Devices and methods for esophageal lengthening and anastomosis formation

Devices and methods can be used to treat long gap esophageal atresia, while obviating much of the delay and complexities associated with current procedures. The devices and methods involve actively stretching the esophagus portions with traction to promote growth of the esophagus portions. Moreover, the devices and methods provided allow... Mayo Foundation For Medical Education And Research

11/02/17 / #20170311953

Body lumen occlusion apparatus and methods

Body lumen occlusion apparatus and methods are described.... Mayo Foundation For Medical Education And Research

10/26/17 / #20170303938

Joint fusion instrumentation and methods

Systems and methods for joint preparation and fusion are disclosed. The system includes a cutting device having a handle, and rigid blade member. The blade member may include cutting edges on first and second sides, and may be curved in one or more planes. The blade member may be deployed... Mayo Foundation For Medical Education And Research

10/26/17 / #20170303972

Joint fusion implant and methods

An implant for fusing a joint between first and second bone portions. The implant includes a screw member, and a washer polyaxially rotatable relative to the screw member. The screw member includes a head, a lag zone, and a threaded engagement zone. The implant includes a fusion zone for joint... Mayo Foundation For Medical Education And Research

10/26/17 / #20170304060

Joint fusion instrumentation and methods

Systems and methods for joint preparation and fusion are disclosed. The system includes a cutting device having a handle, and rigid blade member. The blade member may include cutting edges on first and second sides, and may be curved in one or more planes. The blade member may be deployed... Mayo Foundation For Medical Education And Research

10/26/17 / #20170304113

Gastroduodenal balloon tubes and methods for use in localized hypothermia

Materials and methods for producing localized hypothermia in a patient (e.g., for treatment of acute pancreatitis and pancreatic cancer).... Mayo Foundation For Medical Education And Research

10/26/17 / #20170304527

Wound irrigation system

This document provides devices, systems, and methods for treating patients with wounds. For example, this document provides a multi-lumen tubular device that can deliver wound irrigation, wound suction, and medicinal treatment through the lumens of the tubular device.... Mayo Foundation For Medical Education And Research

10/26/17 / #20170304557

Vaccination delivery system and method

A device can be used for delivering a dose of a vaccine, medicine, medication, drug, or prescription. For example, this document describes a wearable vaccination device that plays an audible sound or musical tune for distracting or entertaining the patient while an intradermal vaccine is delivered via the patient's skin.... Mayo Foundation For Medical Education And Research

10/26/17 / #20170304624

Devices and methods for cardiac pacing and resynchronization

Devices and methods can be used for artificial cardiac pacing and/or resynchronization. For example, this document provides improved electrodes for stimulating and sensing electrical activity of the heart, and provides pacing and resynchronization systems incorporating such electrodes. While the devices and methods provided herein are described primarily in the context... Mayo Foundation For Medical Education And Research

10/26/17 / #20170307617

Methods and materials for treating renal cell carcinoma

This document provides methods and materials related to treating renal cell carcinoma. For example, methods and materials for assessing a cancer patient (e.g., a renal cell carcinoma patient) for tumor or peritumoral tissue containing CD14+ cells and proceeding with a cancer treatment option (e.g., a renal cell carcinoma treatment option)... Mayo Foundation For Medical Education And Research

10/26/17 / #20170308409

Body lumen occlusion apparatus and methods

Body lumen occlusion apparatus and methods are described.... Mayo Foundation For Medical Education And Research

10/26/17 / #20170309048

Computer diagnostic data display

A method for operating a computer system to generate and display multidimensional data. A set of multidimensional data points and a selected deviation range is received at a processor. The processor processes each data point to determine its value about the selected deviation range. Display data representative of data point... Mayo Foundation For Medical Education And Research

10/19/17 / #20170296345

Method for optimization of joint arthroplasty component design

... Mayo Foundation For Medical Education And Research

10/19/17 / #20170296660

Methods and materials for modulating resistance to apoptosis

This document provides methods and materials involved in modulating a cell's ability to be resistant to apoptosis. For example, methods and materials for exposing cells to KLK6 polypeptides, or increased KLK6 polypeptide activity, to promote resistance to apoptosis are provided. In addition, methods and materials for reducing the ability of... Mayo Foundation For Medical Education And Research

10/19/17 / #20170296739

Systems and methods for visualizing fluid enhanced ablation therapy

Systems and methods for visualizing fluid enhanced ablation therapy are described herein. In one embodiment, a method for ablating tissue is provided that includes inserting an elongate body into a tissue volume, heating an imageable fluid within the elongate body to transform the imageable fluid into an imageable therapeutic fluid,... Mayo Foundation For Medical Education And Research

10/19/17 / #20170296793

Weeping balloon devices

Catheters with weeping balloons can be used for various medical purposes. For example, in some embodiments provided herein weeping balloons are used for catheter visualization devices. In some embodiments, weeping balloons are used to deliver therapeutic agents. Weeping balloons can include openings of a selected size and shape through which... Mayo Foundation For Medical Education And Research

10/19/17 / #20170296795

Balloon catheter visualization device including reinforcement features

A balloon catheter visualization device includes a handle, an elongate shaft, and an asymmetrical balloon. The elongate shaft includes a distal end, a proximal end, and defines a lumen and a longitudinal axis extending from the proximal end to the distal end. The proximal end is coupled to the handle.... Mayo Foundation For Medical Education And Research

10/19/17 / #20170298439

Detecting colorectal neoplasia

Provided herein is technology for colorectal neoplasia screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of colorectal neoplasia in 1) individuals at, older or younger than 50 years of age, or 2) individuals having Lynch Syndrome.... Mayo Foundation For Medical Education And Research

10/19/17 / #20170299681

Sparse reconstruction strategy for multi-level sampled mri

Described here are systems and methods for reconstructing images from multi-level sampled data acquired with a magnetic resonance imaging (MRI) system. An alternating direction method-of multipliers (ADMM) strategy is implemented for sparse reconstruction of multi-level sampled data, and which decomposes the reconstruction problem into simpler subproblems and enables certain operations... Mayo Foundation For Medical Education And Research

10/19/17 / #20170301427

Solution target for cyclotron production of radiometals

Methods of producing and isolating 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 13N, 52Mn, or 44Sc and solution targets for use in the methods are disclosed. The methods of producing 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 13N, 52Mn, or 44Sc include irradiating a closed target system with... Mayo Foundation For Medical Education And Research

10/12/17 / #20170290582

Thorascopic heart valve repair method and apparatus

An instrument for performing thorascopic repair of heart valves includes a shaft for extending through the chest cavity and into a heart chamber providing access to a valve needing repair. A movable tip on the shaft is operable to capture a valve leaflet and a needle is operable to penetrate... Mayo Foundation For Medical Education And Research

10/12/17 / #20170290744

Gastrointestinal feeding tubes with enhanced skin surface bumpers

Gastric and intestinal feeding tube devices and methods can be enhanced to provide better patient outcomes. For example, this document provides gastric and intestinal feeding tube devices that include an external bumper with pressure sensors and pressure indicators that facilitate usage of the feeding tube devices within an appropriate range... Mayo Foundation For Medical Education And Research

10/12/17 / #20170291952

Carrier-binding agent compositions and methods of making and using the same

Described herein are compositions of antibodies and carrier proteins and methods of making and using the same, in particular, as a cancer therapeutic. Also described are lyophilized compositions of antibodies and carrier proteins and methods of making and using the same, in particular, as a cancer therapeutic.... Mayo Foundation For Medical Education And Research

10/05/17 / #20170281006

Systems and methods for assessing properties of biological tubes

A system and method is provided for measuring a mechanical property of a biological tube. The system and method operate to arrange a plurality of piezoelectric elements about the biological tube and apply a predetermined force or transduce an endogeneous or exogeneous force to the biological tube. The system and... Mayo Foundation For Medical Education And Research

10/05/17 / #20170281193

Closure and ablation of body viscera and conduits

Devices and methods can be used to treat heart conditions. Some such devices include endocardial occlusion and ablation devices. For example, such devices can be used for closing and ablating the left atrial appendage to treat atrial fibrillation and to reduce the potential for embolic stroke. In addition, this document... Mayo Foundation For Medical Education And Research

10/05/17 / #20170281212

Methods and devices for localizing, delineating and anchoring liver lesions for resection

This document provides methods and devices for localizing, delineating and/or anchoring lesions for resection from a solid organ (e.g., liver, breast, or pancreas). For example, this document provides devices that can be positioned within liver tissue to help delineate liver tumor tissue from normal liver tissue and to help hold... Mayo Foundation For Medical Education And Research

10/05/17 / #20170285034

Methods and materials for identifying and treating mammals having lung adenocarcinoma characterized by neuroendocrine differentiation

This document provides methods and materials involved in identifying mammals having lung adenocarcinoma characterized by neuroendocrine differentiation as well as methods and materials involved in treating mammals having lung adenocarcinoma characterized by neuroendocrine differentiation. For example, methods and materials for using ASCL1 and RET expression levels to identify lung cancer... Mayo Foundation For Medical Education And Research

09/28/17 / #20170274211

System and suppressing vestibular activity of a human subject

A system for suppressing vestibular activity of a human subject includes an electronics module configured to generate one or more electrical stimulation signals. A plurality of electrodes each placed proximate a predetermined location on a head of a human subject is configured to deliver the one or more electrical stimulation... Mayo Foundation For Medical Education And Research

09/28/17 / #20170275700

Methods and materials for identifying metastatic malignant skin lesions and treating skin cancer

This document provides methods and materials for identifying metastatic malignant skin lesions (e.g., malignant pigmented skin lesions). For example, methods and materials for using quantitative PCR results and correction protocols to reduce the impact of basal keratinocyte contamination on the analysis of test sample results to identify metastatic malignant skin... Mayo Foundation For Medical Education And Research

Patent Packs
09/21/17 / #20170265747

System and automatic polyp detection using global geometric constraints and local intensity variation patterns

A system and methods for polyp detection using optical colonoscopy images are provided. In some aspects, the system includes an input configured to receive a series of optical images, and a processor configured to process the series of optical images with steps comprising of receiving an optical image from the... Mayo Foundation For Medical Education And Research

09/14/17 / #20170258521

Pericardial modification devices and methods

Devices and methods are described for the treatment of heart conditions such as heart failure with preserved ejection fraction, including diastolic heart failure, by performing a pericardial modification procedure. Intraoperative test procedures for assessing the efficacy of the pericardial modification procedure are also described.... Mayo Foundation For Medical Education And Research

09/14/17 / #20170258611

Devices and methods for forming stents in vivo

Materials and methods for generating conformable stents at sites of stenosis in bodily vessels (e.g., blood vessels) are provided herein.... Mayo Foundation For Medical Education And Research

09/14/17 / #20170260496

Cell culture media compositions for primary cells

Platelet lysate compositions and cell culture media compositions for maintaining and/or growing mammalian cells, such as mammalian endothelial cells (ECs) and mammalian endothelial progenitor cells (EPCs), in particular human ECs (huECs) and human EPCs (huEPCs), such as primary huECs and primary huEPCs, are provided. The cell culture media compositions contain... Mayo Foundation For Medical Education And Research

09/14/17 / #20170260571

Methods and materials for treating endometrial cancer

This document provides methods and materials for detecting and/or treating endometrial hyperplasia and/or endometrial cancer. For example, this document provides methods and materials for identifying a female mammal as having endometrial hyperplasia and administering a therapy (e.g., hormone therapy) to the female mammal. For example, this document provides methods and... Mayo Foundation For Medical Education And Research

09/07/17 / #20170252152

Self-centering guide catheter

An example medical device is disclosed. The device includes a tubular member having a lumen defined therein and a distal end portion, the distal end portion defining a guidewire port. The medical device also includes an expandable frame disposed along the distal end portion of the tubular member, the expandable... Mayo Foundation For Medical Education And Research

09/07/17 / #20170252482

Hip implant

Provided herein are hip implant devices and related surgical methods. The hip implants and methods can optionally be used in patients of Asian descent.... Mayo Foundation For Medical Education And Research

09/07/17 / #20170253873

Polypeptide inhibitors of smad3 polypeptide activities

This document provides polypeptide inhibitors of Smad3 polypeptide activities. For example, methods and materials for using polypeptides (e.g., polypeptides designed to include both a cell penetrating amino acid sequence and an amino acid segment of a SH3 domain of a SNX9 polypeptide) to inhibit one or more Smad3 polypeptide activities... Mayo Foundation For Medical Education And Research

08/17/17 / #20170232072

Treating cardiovascular or renal diseases

This document provides methods and materials for treating cardiovascular and/or renal diseases. For example, AAV9 vectors designed to express natriuretic polypeptides, nucleic acid molecules encoding natriuretic polypeptides, methods for making AAV9 vectors, and methods for using such vectors or molecules to treat cardiovascular and/or renal diseases are provided.... Mayo Foundation For Medical Education And Research

08/17/17 / #20170232102

Hematologic cancer treatments

Disclosed herein are improved compositions and methods involved in treating hematologic cancers, i.e., cancers that begin in blood-forming tissue, such as the bone marrow, or in the cells of the immune system. The compositions comprise complexes containing albumin-containing nanoparticles (e.g., ABRAXANE® nanoparticles) and antibodies. The compositions are used to effect... Mayo Foundation For Medical Education And Research

08/10/17 / #20170224680
08/10/17 / #20170226073

Compounds and methods for treating cancer

This document provides compounds, compositions, and methods for treating cancers including renal cancer (e.g., renal cell carcinoma) as well as ovarian, breast, prostate, colon, pancreatic, bladder, liver, lung, and thyroid cancers and melanoma. For example, compounds, compositions, and methods for using one or more inhibitors of SCD1 to treat renal... Mayo Foundation For Medical Education And Research

08/03/17 / #20170216286

Killing senescent cells and treating senescence-associated conditions using a src inhibitor and a flavonoid

Provided herein are methods and uses for treatment or prophylaxis of a senescent cell associated disease or disorder by administering a senolytic combination comprising dasatinib and quercetin or an analog thereof to a subject in need thereof. In certain embodiments, the senescent cell associated disease or disorder is a cardiovascular... Mayo Foundation For Medical Education And Research

08/03/17 / #20170216453

Treating lymphomas

This document provides methods and materials related to treating lymphomas. For example, methods and materials relating to the use of a composition containing albumin-containing nanoparticle/antibody complexes (e.g., ABRAXANE®/anti-CD20 polypeptide antibody complexes) to treat lymphomas are provided.... Mayo Foundation For Medical Education And Research

08/03/17 / #20170218086

Methods and materials for treating cancer

This document provides methods and materials related to treating cancer. For example, methods and materials for using particles (e.g., nanoparticles) containing (a) one or more molecules having the ability to bind to a cancer cell (e.g., a human breast cancer cell) and (b) one or more molecules having the ability... Mayo Foundation For Medical Education And Research

Patent Packs
08/03/17 / #20170221594

Solution target for cyclotron production of radiometals

Methods of producing and isolating 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 13N, 52Mn, or 44Sc and solution targets for use in the methods are disclosed. The methods of producing 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 13N, 52Mn, or 44Sc include irradiating a closed target system with... Mayo Foundation For Medical Education And Research

07/27/17 / #20170209057

Systems, devices and methods for assessment of body cavity pressures

Systems, devices and methods that can be used to obtain objective pressure measurements in a body cavity using one or more monitoring bladders mounted on a catheter. The monitoring bladders may be adapted to connect or be connected to a system capable of providing objective pressure measurements indicative of the... Mayo Foundation For Medical Education And Research

07/27/17 / #20170209060

Detection of atrial fibrillation causes

This document provides devices and methods for the treatment of heart conditions. For example, this document provides devices and methods for detecting heart rotors such that effectively targeted cardiac fibrillation treatments can be provided.... Mayo Foundation For Medical Education And Research

07/27/17 / #20170209117

System and measurement of longitudinal and circumferential wave speeds in cylindrical vessels

Systems and methods are provided for measuring and isolating circumferential wave speed within a vessel wall of a substantially cylindrical vessel. The methods include measuring a motion at a first location and a second location opposite the first location and isolating the circumferential wave speed. The methods also include generating... Mayo Foundation For Medical Education And Research

07/27/17 / #20170209435

Methods and compositions for killing senescent cells and for treating senescence-associated diseases and disorders

Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic... Mayo Foundation For Medical Education And Research

07/27/17 / #20170209466

Methods and materials for reducing development of stenosis of arteriovenous fistulas

This document provides methods and materials for reducing development of stenosis of arteriovenous fistulas. For example, methods and materials for reducing IEX-1 polypeptide expression or activity within a mammal (e.g., a human) to reduce venous neointimal hyperplasia and/or the development of stenosis of arteriovenous fistulas are provided.... Mayo Foundation For Medical Education And Research

07/27/17 / #20170209569

Monovalent anti-cd3 adjuvants

This document provides methods and materials related to using monovalent anti-CD3 antibodies (e.g., monovalent anti-CD3 Fab fragments) as adjuvants to increase the immune response produced against an antigen (e.g., a tumor associated antigen). For example, vaccine compositions containing monovalent anti-CD3γε Fab fragments in combination with tumor associated antigens (e.g., tumor... Mayo Foundation For Medical Education And Research

07/27/17 / #20170209632

Application-based mechanical circulatory support device assessments

This document describes, among other things, a computer-implemented method that includes receiving, by a computing system, data that represents a plurality of measurements associated with a mechanical circulatory support device connected to a patient over a period of time. The method can include determining, based on the plurality of measurements,... Mayo Foundation For Medical Education And Research

07/27/17 / #20170209691

Percutaneous temporary epicardial pacemaker system

This document provides devices and methods for the treatment of heart conditions. For example, this document provides a percutaneous temporary epicardial pacemaker device and system for treating heart arrhythmia.... Mayo Foundation For Medical Education And Research

07/27/17 / #20170211146

Methods and materials for treating endometrial cancer

This document provides methods and materials for treating endometrial cancer. For example, methods and materials for identifying a female mammal as having endometrial cancer and surgically removing at least the uterus of the female are provided.... Mayo Foundation For Medical Education And Research

07/20/17 / #20170204185

B7-h3 and b7-h4, novel immunoregulatory molecules

The invention provides novel B7-H3 and B7-H4 polypeptides useful for co-stimulating T cells, isolated nucleic acid molecules encoding them, vectors containing the nucleic acid molecules, and cells containing the vectors. Also included are methods of making and using these co-stimulatory polypeptides.... Mayo Foundation For Medical Education And Research

07/13/17 / #20170196541

System and quantitative muscle ultrasoound for diagnosis of neuromuscular disease

Systems and methods are provided for diagnosing neuromuscular disease in a patient suspected of having a neuromuscular disease, Phantoms for use in these systems and methods are also provided. Methods are further provided for determining a normalized ultrasound data value for a patient of interest having a known age, weight,... Mayo Foundation For Medical Education And Research

07/13/17 / #20170196831

Nanoparticle complexes of paclitaxel, anti-her2 antibody, and albumin

Described are nanoparticle complexes comprising paclitaxel, albumin and anti-HER2 antibody. The nanoparticle complexes are suitable for the treatment of cancer, in particular cancer that expresses HER2.... Mayo Foundation For Medical Education And Research

07/13/17 / #20170196832

Nanoparticle complexes of paclitaxel, anti-cd52 antibodies, and albumin

Described are nanoparticle complexes comprising paclitaxel, albumin and anti-CD52 antibody. The nanoparticle complexes are suitable for the treatment of cancer, in particular cancer that expresses CD52.... Mayo Foundation For Medical Education And Research

07/13/17 / #20170196833

Nanoparticle complexes of paclitaxel, bevacizumab, and albumin

Described are nanoparticle complexes comprising paclitaxel, albumin and anti-HER2 antibody. The nanoparticle complexes are suitable for the treatment of cancer, in particular cancer that expresses VEGF.... Mayo Foundation For Medical Education And Research

07/13/17 / #20170196857

Methods and compositions for killing senescent cells and for treating senescence-associated diseases and disorders

Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic... Mayo Foundation For Medical Education And Research

07/13/17 / #20170196858

Methods and compositions for killing senescent cells and for treating senescence-associated diseases and disorders

Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic... Mayo Foundation For Medical Education And Research

07/13/17 / #20170196999

Treatment of meningiomas using phenylbenzothiazole, stilbene, biphenylalkyne, or pyridine derivitives

A method and composition for treating a meningioma in a subject are disclosed. The method includes the step of administering to the subject a therapeutically effective amount of a composition including a cytotoxic agent associated with a phenylbenzothiazole derivative or a stilbene derivative or a biphenylalkyne derivative that accumulates within... Mayo Foundation For Medical Education And Research

07/13/17 / #20170198253

Methods and compositions for killing senescent cells and for treating senescence-associated diseases and disorders

Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic... Mayo Foundation For Medical Education And Research

07/13/17 / #20170198361

Detecting neoplasm

This document relates to methods and materials for detecting premalignant and malignant neoplasms. For example, methods and materials for determining whether or not a stool sample from a mammal contains nucleic acid markers or polypeptide markers of a neoplasm are provided.... Mayo Foundation For Medical Education And Research

07/06/17 / #20170189050

Systems, devices, and methods for accessing body tissue

Systems, devices and methods to access and/or treat targeted body tissue (e.g., tendon tissue, ligament tissue, muscle tissue, bony tissue, and the like) under the guidance of ultrasound imaging equipment are described. Such systems can permit the intra-operative identification of the targeted tissue and the ability to deliver the appropriate... Mayo Foundation For Medical Education And Research

07/06/17 / #20170189455

Prevotella histicola preparations and the treatment of autoimmune conditions

This document provides methods and materials related to Prevotella histicola preparations. For example, Prevotella histicola preparations in the form of an oral medicament or dietary supplement (e.g., a pill, tablet, capsule) are provided. In addition, methods and materials for using a Prevotella histicola preparation provided herein as an anti-inflammatory agent... Mayo Foundation For Medical Education And Research

07/06/17 / #20170192077

Systems and methods for a magnetic resonance elastography phantom

A phantom for magnetic resonance elastography (MRE) is provided. In particular, systems and methods for a phantom that is capable of generating a wave-like pattern in MRE images where a wavelength of the generated wave-like pattern is controlled by the phantom geometry. The geometrically controlled wavelength enables the phantom to... Mayo Foundation For Medical Education And Research








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