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Merck Sharp & Dohme Corp patents


Recent patent applications related to Merck Sharp & Dohme Corp. Merck Sharp & Dohme Corp is listed as an Agent/Assignee. Note: Merck Sharp & Dohme Corp may have other listings under different names/spellings. We're not affiliated with Merck Sharp & Dohme Corp, we're just tracking patents.

ARCHIVE: New 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "M" | Merck Sharp & Dohme Corp-related inventors




Date Merck Sharp & Dohme Corp patents (updated weekly) - BOOKMARK this page
07/07/16Mono- and di-peg il-10 production; and uses
03/26/15Mono- and di-peg il-10 production; and uses
01/08/15Dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes
10/04/12Novel cationic lipids with short lipid chains for oligonucleotide delivery
08/09/12Combination therapy using a beta 3 adrenergic receptor agonists and an antimuscarinic agent
08/25/16 new patent  Polycyclic heterocycle derivatives and methods of use thereof for the treatment of viral diseases
08/25/16 new patent  Cathepsin cysteine protease inhibitors
08/18/16Novel pyrrolidine derived beta 3 adrenergic receptor agonists
08/11/16Trka kinase inhibitors, compositions and methods thereof
08/11/16Substituted quinolizine derivatives useful as hiv integrase inhibitors
08/11/16Solid forms of ceftolozane
08/11/16Method of obtaining thermostable dried vaccine formulations
08/11/16Trka kinase inhibitors, compositions and methods thereof
08/11/16Aryl methyl benzoquinazolinone m1 receptor positive allosteric modulators
08/11/16Factor xia inhibitors
08/11/16Trka kinase inhibitors, compositions and methods thereof
08/04/16Formulations for cgrp receptor antagonists
08/04/16Tricyclic gyrase inhibitors
08/04/16C5-spiro iminothiazine dioxides as bace inhibitors, compositions, and their use
07/28/162-pyridyloxy-4-ester orexin receptor antagonists
07/28/162,2-difluorodioxolo a2a receptor antagonists
07/28/16Fc containing polypeptides having increased binding to fcgammariib
07/21/16Antidiabetic tricyclic compounds
07/21/16Inhibitors of the renal outer medullary potassium channel
07/21/16Purine inhibitors of human phosphatidylinositol 3-kinase delta
07/14/16Modulation of tumor immunity
07/14/16Preparation and use of 3-pyridyl substituted- 6,6-difluoro bicyclic himbacine derivatives as par-1 receptor antagonists
07/14/16Preparation and use of 7a-heterocycle substituted- 6,6-difluoro bicyclic himbacine derivatives as par-1 receptor antagonists
07/14/16Compounds inhibiting leucine-rich repeat kinase enzyme activity
07/07/16Ceftolozane-tazobactam pharmaceutical compositions
07/07/16Immediate-release tablet formulations of a thrombin receptor antagonist
07/07/16Methods of immunization with varicella zoster virus antigen
07/07/16Treating cancer with a combination of a pd-1 antagonist and dinaciclib
07/07/16Piperazine-substituted [1,2,4]triazolo[1,5-c]quinazolin-5-amine compounds with a2a antagonist properties
07/07/16Methods and compositions for co-expression of polypeptides of inerest and il6
07/07/16Expression vectors for recombinant protein production in mammalian cells
06/30/16Preparation and use of 7a-amide substituted- 6,6-difluoro bicyclic himbacine derivatives as par-1 receptor antagonists
06/30/16Thiazole orexin receptor antagonists
06/23/16Oxazole orexin receptor antagonists
06/23/16Process for making beta 3 agonists and intermediates
06/23/167-aminocephem derivative compounds
06/23/16Forms of r)-3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-5-hydroxymethyl oxazolidin-2-one dihydrogen phosphate
06/16/16Formulations for cathepsin k inhibitors with vitamin d
06/16/16Oral pharmaceutical formulation of omarigliptin
06/16/16Substituted amidopyrazole inhibitors of interleukin receptor-associated kinases (irak-4)
06/16/16Pegylated interleukin-10
06/09/16Quinoline carboxamide and quinoline carbonitrile derivatives as mglur2-negative allosteric modulators, compositions, and their use
06/09/16Quinoline carboxamide and quinoline carbonitrile derivatives as mglur2-negative allosteric modulators, compositions, and their use
06/09/16Quinoline carboxamide and quinoline carbonitrile derivatives as mglur2-negative allosteric modulators, compositions, and their use
06/09/16Quinoline carboxamide and quinoline carbonitrile derivatives as mglur2-negative allosteric modulators, compositions, and their use
06/09/16Piperazine derivatives as hiv protease inhibitors
06/09/16Co-crystal of the par-1 receptor antagonists vorapaxar and asprin
06/02/16Dengue virus vaccine compositions and methods of use thereof
05/26/16Heterocyclic compounds and methods of use thereof for the treatment of hepatitis c
05/26/16Non-nucleoside reverse transcriptase inhibitors
05/26/16Triazolo-pyrazinyl derivatives useful as soluble guanylate cyclase activators
05/19/16Substituted benzofuran compounds and methods of use thereof for the treatment of viral diseases
05/19/16Aminotetrahydropyrans as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes
05/12/16Substituted benzofuran compounds and methods of use thereof for the treatment of viral diseases
05/12/16Process for making cgrp receptor antagonists
05/12/16Cmv neutralizing antigen binding proteins
05/12/16Methods of measuring gene expression in facs-sorted cells
05/12/16Compositions and methods for treating cancer
05/05/16Process for the preparation of chiral tert-butyl 4-((1r,2s,5r)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamido)piperidine-1-carboxylate derivatives and (2s,5r)-7-oxo-n-piperidin-4-yl-6-(sulfoxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide
05/05/16Cyclic phosphonate substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases
04/28/16Treating infections with ceftolozane/tazobactam in subjects having impaired renal function
04/28/16Co-agonists of the glucagon and glp-1 receptors
04/21/16Combination therapies for cancer
04/21/16Imidazole derivatives and methods of use thereof for improving the pharmacokinetics of a drug
04/21/16Fused tricyclic heterocyclic compounds as hiv integrase inhibitors
04/14/162-hydroxymethyl-substituted orexin receptor antagonists
04/07/16Selective glycosidase inhibitors and uses thereof
03/24/16Process of making and using pharmaceutical formulations of antineoplastic agents
03/24/16Method for preparing antibodies having improved properties
03/24/16Immunohistochemical assay for detecting expression of programmed death ligand 1 (pd-l1) in tumor tissue
03/24/16Assay for determining endogenous levels of analyte in vivo
03/17/16Recombinant subunit dengue virus vaccine
03/17/16Amidation process
03/17/16Crystalline polymorphic forms of an antidiabetic compound
03/17/16Quinoline amide m1 receptor positive allosteric modulators
03/17/16Alpha 7 nicotinic acetylcholine receptor modulators and uses thereof-iii
03/17/16Cetp inhibitors
03/10/16Hydroxy-substituted orexin receptor antagonists
03/10/16Halo and trifluoromethyl substituted orexin receptor antagonists
03/10/16Novel compounds that are erk inhibitors
03/10/16Fdf03 antibodies and uses thereof
03/03/16Thiazole-substituted aminoheteroaryls as spleen tyrosine kinase inhibitors
03/03/16Thiazole-substituted aminopyrimidines as spleen tyrosine kinase inhibitors
03/03/164-pyridone derivative compounds and uses thereof as hiv integrase inhibitors
02/25/16Immobilized ketoreductases and process for making and using immobilized ketoreductase
02/18/162'-disubstituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases
02/18/16Factor xia inhibitors
02/11/16Triazolopyridyl compounds as aldosterone synthase inhibitors
02/11/16Adapted lepidopteran insect cells for the production of recombinant proteins
02/11/16Biocatalytic transamination process
02/11/16Methods and compositions for treating cancer
02/11/16C6-azaspiro iminothiadiazine dioxides as bace inhibitors, compositions, and their use
02/04/16Imidazopyridyl compounds as aldosterone synthase inhibitors
01/28/16Inhibitors of the renal outer medullary potassium channel
01/28/16Process for preparing chiral dipeptidyl peptidase-iv inhibitors
01/21/16S-imino-s-oxo-iminothiazine compounds as bace inhibitors, compositions, and their use
01/21/16S-imino-s-oxo-iminothiadiazine compounds as bace inhibitors, compositions, and their use
01/21/162-pyridyloxy-4-ether orexin receptor antagonists
01/21/16Substituted pyridizinone derivatives as pde10 inhibitors
01/21/16C2-azaspiro iminothiazine dioxides as bace inhibitors, compositions, and their use
01/21/16Cell line 3m
01/14/16Compositions and methods for treating cancer
01/14/16Compounds inhibiting leucine-rich repeat kinase enzyme activity
01/14/16Compounds inhibiting leucine-rich repeat kinase enzyme activity
01/14/16Compounds inhibiting leucine-rich repeat kinase enzyme activity
01/14/16Compounds inhibiting leucine-rich repeat kinase enzyme activity
01/07/16Gastro-retentive formulations
01/07/16Ceftolozane antibiotic compositions
01/07/16Novel indole derivatives useful as anti-diabetic agents
01/07/16Antidiabetic bicyclic compounds
01/07/16Inhibitors of the renal outer medullary potassium channel
12/31/15O-glycosylated carboxy terminal portion (ctp) peptide-based insulin and insulin analogues
12/31/15Methods for increasing n-glycan occupancy and reducing production of hybrid n-glycans in pichia pastoris strains lacking alg3 expression
12/24/15Tetracyclic heterocycle compounds and methods of use thereof for the treatment of hepatitis c
12/24/152,6,7 substituted purines as hdm2 inhibitors
12/24/15Tetracyclic heterocycle compounds and methods of use thereof for the treatment of hepatitis c
12/24/15Factor ixa inhibitors
12/24/15Mdl-1 ligand
12/24/15Immobilized transaminases and process for making and using immobilized transaminase
12/17/15Beta-amino heterocyclic dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
12/17/15Heterobicyclo-substituted [1,2,4]triazolo[1,5-c]quinazolin-5-amine compounds with a2a antagonist properties
12/17/15Tetracyclic heterocycle compounds and methods of use thereof for the treatment of hepatitis c
12/10/15Substituted isoquinolines as crth2 receptor modulators
12/10/15Iminothiadiazine dioxides containing a thioamide, amidine, or amide oxime group as bace inhibitors, compositions, and their use
12/10/15Thiazole-substituted aminopyridines as spleen tyrosine kinase inhibitors
12/10/15Purine inhibitors of human phosphatidylinositol 3-kinase delta
12/10/152,6,7,8 substituted purines as hdm2 inhibitors
12/10/15Btk inhibitors
12/10/15Btk inhibitors
12/10/15Antibodies that bind to human programmed death ligand 1 (pd-l1)
12/03/15Spirocyclic cetp inhibitors
12/03/15Dual chamber mixing syringes and methods of using same
12/03/15Medication injector with near-empty alert
12/03/15Aminotetrahydropyrans as dipeptidyl peptidase-iv inhibitors for the treatment of diabetes
12/03/15C2,c6 oxacyclic-fused thiazine dioxide compounds as bace inhibitors, compositions, and their use
11/26/15Heterocycle-substituted tetracyclic compounds and methods of use thereof for the treatment of viral diseases
11/26/15Novel 2-pyridinecarboxamide derivatives, compositions containing such compounds, and methods of treatment
11/26/15Isotopically labeled biaryl urea compounds
11/26/15Novel glucokinase activator compounds, compositions containing such compounds, and methods of treatment
11/26/15Novel antibacterial agents for the treatment of gram positive infections
11/26/15Pmt2-, och1-, pmt5- mutant cells
11/19/15Process for making reverse transcriptase inhibitors
11/19/15Amino-pyrimidine-containing spleen tyrosine kinase (syk) inhibitors
11/19/154-pyridinonetriazine derivatives as hiv integrase inhibitors
11/19/15Substituted pyrrolopyrimidines as hdm2 inhibitors
11/19/15Inhibitors of the renal outer medullary potassium channel
11/19/15Factor ixa inhibitors
11/19/15Process for purifying insulin and analogues thereof
11/19/15Liquid formulations for an anti-tnf alpha antibody
11/19/15Solution formulations of engineered anti-il-23p19 antibodies
11/12/15Methods of treating diabetes by administering a glucagon receptor antagonist in combination with a cholesterol absorption inhibitor
11/12/15Indazole compounds as aldosterone synthase inhibitors
11/12/15Method for treating a disease associated with soluble, oligomeric species of amyloid beta 1-42
11/12/152-pyridylamino-4-nitrile-piperidinyl orexin receptor antagonists
11/12/153-ester-4 substituted orexin receptor antagonists
11/12/152-pyridyloxy-4-nitrile-4-substituted orexin receptor antagonists
11/12/15Factor ixa inhibitors
11/12/154-fluoropiperidine orexin receptor antagonists
11/12/15Biomarkers for psoriasis treatment response
11/05/15Nucleoside kinase bypass compositions and methods
11/05/15Syn3 compositions and methods
11/05/15Thrombin inhibitors
11/05/15Nucleoside kinase bypass compositions and methods
11/05/15Disulfide masked prodrug compositions and methods
10/29/15Aldosterone synthase inhibitors
10/29/15Therapeutic thiazolidinone compounds
10/29/15Iminothiadiazine dioxide compounds as bace inhibitors, compositions and their use
10/29/15Cyclobutyl benzimidazoles as pde 10 inhibitors
10/29/15Cyclopropyl imidazopyridine pde10 inhibitors
10/29/15Pyrimidine pde10 inhibitors
10/29/15Spirocyclic sulfones as gamma secretase inhibitors
10/29/15Oxyntomodulin analogs
10/29/15On-column refolding and purifying of lipoproteins
10/29/15Lyophilized spherical pellets of anti-il-23 antibodies
10/29/15Conditional replicating viral vectors
10/22/15Inhibitors of the renal outer medullary potassium channel
10/22/15Improved cultivation media and process for improved protein production by pichia strains
10/22/15Rorgammat inhibitors
10/22/15Glycosidase inhibitors and uses thereof
10/22/15Prodrug bipyridylaminopyridines as syk inhibitors
10/22/15Regioselective n-2 arylation of indazoles
10/22/15Inhibitors of the renal outer medullary potassium channel
10/22/15Inhibitors of irak4 activity
10/22/15Inhibitors of catechol o-methyl transferase and their use in the treatment of psychotic disorders
10/22/152'-alkynyl substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases
10/22/15Improved cultivation media and process for improved protein production by pichia strains
10/22/15Engineered lower eukaryotic host strains deficient in grr1 activity for recombinant protein
10/15/15Process for making agglomerates using acoustic mixing technology
10/15/15Liquid formulations for tnfr:fc fusion proteins
10/15/152-pyridyloxy-3-substituted-4-nitrile orexin receptor antagonists
10/15/15Substituted pyridone derivatives as pde10 inhibitors
10/15/15Glycosidase inhibitors and uses thereof
10/15/15Modified apol1 polypeptides
10/08/15Secondary alcohol substituted triazoles as pde10 inhibitors
10/08/15Mineralocorticoid receptor antagonists
10/08/15Tricyclic substituted thiadiazine dioxide compounds as bace inhibitors, compositions and their use
10/08/15Amino-pyridine-containing spleen tyrosine kinase (syk) inhibitors
10/08/15N-substituted indazole sulfonamide compounds with selective activity in voltage-gated sodium channels
10/08/15Novel azabenzimidazole hexahydrofuro[e,2-b]furan derivatives
10/08/15Process for the preparation of an intermediate for an orexin receptor antagonists
10/01/15Glycosidase inhibitors and uses thereof
10/01/15Substituted cyclopropyl compounds, compositions containing such compounds and methods of treatment
10/01/15Substituted spiropiperidinyl compounds useful as gpr120 agonists
10/01/15Inhibitors of irak4 activity
10/01/15Tricyclic substituted thiadiazine dioxide compounds as bace inhibitors, compositions and their use
10/01/152'-cyano substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases
10/01/15Compound diversification using late stage functionalization
10/01/154'-substituted nucleoside reverse transcriptase inhibitors
10/01/15Crz1 mutant fungal cells
09/24/15Posaconazole intravenous solution formulations stabilized by substituted beta-cyclodextrin
09/24/15Novel compounds that are erk inhibitors
09/24/15Hcv ns3 protease inhibitors
09/17/15Novel compounds that are erk inhibitors
09/17/15Antibodies, kit and detecting amyloid beta oligomers
09/10/15Composition for inhibition of cathepsin k
09/10/152-pyridyloxy-3-ester-4-nitrile orexin receptor antagonists
09/10/15Benzoxazolinone compounds with selective activity in voltage-gated sodium channels
09/10/15Quantification of tau in biological samples by immunoaffinity enrichment and mass spectrometry
09/03/15Substitued benzofuran compounds and methods of use thereof for the treatment of viral diseases
09/03/15Inhibitors of hepatitis c virus replication
08/27/15Triazolyl derivatives as syk inhibitors
08/20/15Substituted phenyl-spleen tyrosine kinase (syk) inhibitors
08/20/15Crystalline form of a reverse transcriptase inhibitor
08/13/15Indoline compounds as aldosterone synthase inhibitors
08/13/15Treating diabetes with dipeptidyl peptidase-iv inhibitors
08/06/154-heteroaryl substituted benzoic acid compounds as rorgammat inhibitors and uses thereof
08/06/15Glycosidase inhibitors and uses thereof
08/06/15Glycosidase inhibitors and uses thereof
08/06/15Novel benzimidazole tetrahydrofuran derivatives
08/06/15Substituted naphthyridinedione derivatives as hiv integrase inhibitors
08/06/153-aminocycloalkyl compounds as rorgammat inhibitors and uses thereof
07/30/15Inactivated varicella zoster virus vaccines, methods of production, and uses thereof
07/30/15Novel azabenzimidazole tetrahydropyran derivatives
07/30/15N-alkylated indole and indazole compounds as rorgammat inhibitors and uses thereof
07/23/15Novel azabenzimidazole tetrahydrofuran derivatives
07/23/15Aliphatic spirolactam cgrp receptor antagonists
07/23/15Macrocyclic compounds as hiv integrase inhibitors
07/16/15Crystalline polymorphic forms of an antidiabetic compound
07/16/15Sulfonamide derivatives and methods of use thereof for improving the pharmacokinetics of a drug
07/16/15Anti-ilt5 antibodies and ilt5-binding antibody fragments
07/16/15Mammalian expression vector puhab
07/09/15Solid dosage formulations of an orexin receptor antagonists
07/09/153-cyclohexenyl and cyclohexyl substituted indole and indazole compounds as rorgammat inhibitors and uses thereof
07/09/15Pyrazolyl derivatives as syk inhibitors



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