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Micromass Uk Limited
Micromass Uk Limited_20100107

Micromass Uk Limited patents


Recent patent applications related to Micromass Uk Limited. Micromass Uk Limited is listed as an Agent/Assignee. Note: Micromass Uk Limited may have other listings under different names/spellings. We're not affiliated with Micromass Uk Limited, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "M" | Micromass Uk Limited-related inventors


Method of charge state selection

A method of mass spectrometry or ion mobility spectrometry is disclosed in which analyte ions of a desired charge state are isolated. The method comprises: separating analytes according to their electrophoretic mobility; ionising the analytes; and mass filtering the resulting analyte ions, wherein the mass to charge ratios of the... Micromass Uk Limited

Method of charge reduction of electron transfer dissociation product ions

A mass spectrometer is disclosed wherein highly charged fragment ions resulting from Electron Transfer Dissociation fragmentation of parent ions are reduced in charge state within a Proton Transfer Reaction cell by reacting the fragment ions with a neutral superbase reagent gas such as Octahydropyrimidolazepine.... Micromass Uk Limited

Mass spectrometer

A mass spectrometer is disclosed comprising a mass selective ion trap and a quadrupole rod set mass filter arranged downstream of the mass selective ion trap. Ions are mass selectively ejected from the ion trap in a substantially synchronised manner with the scanning of the mass filter in order to... Micromass Uk Limited

Method of calibrating ion signals

A method of mass or ion mobility spectrometry is disclosed comprising: providing an ion source for generating analyte ions and reference ions; providing a mass analyser or ion mobility separator (IMS); providing an ion trap between the ion source and the mass analyser or IMS; guiding reference ions from the... Micromass Uk Limited

Mass spectrometer with bypass of a fragmentation device

A method for analyzing a mixture of components includes forming precursor ions from the components, alternately causing the precursor ions to pass to and to by-pass a fragmentation device, to form product ions from the precursor ions that pass to the device and to form substantially fewer product ions from... Micromass Uk Limited

Efficient ion trapping

An ion trapping system is disclosed comprising an ion urging system for urging ions to spread out within an ion trapping region. Alternatively, the ion trapping system may deflect ions such that ions enter the ion trapping region at different locations. Alternatively, an ion deflector may be arranged upstream of,... Micromass Uk Limited

Method of separating ions

The present disclosure relates generally to a method of separating ions according to their ion mobility, comprising (i) accumulating a first population of ions in a first region of an ion mobility separator, (ii) separating said first population of ions according to their ion mobility in said first region of... Micromass Uk Limited

Dynamic post column addition

A method of ionising a sample is disclosed comprising performing an initial experiment comprising: (i) adding one or more reagents to an analyte sample; (ii) varying the composition and/or concentration of the one or more reagents; (iii) ionising the analyte sample including the one or more reagents; (iv) determining the... Micromass Uk Limited

In-source chemical modification of non polar analytes using atmospheric pressure chemical ionisation source

A method for analysing an aliphatic compound by mass spectrometry which comprises: (i) ionising an aliphatic compound in the presence of a heterocyclic modifier; and (ii) mass analysing the resulting ions to obtain mass spectrometric data.... Micromass Uk Limited

Probe assembly connector

An attachment device for releasably attaching a fluid line to a fluid inlet or outlet is disclosed. The device comprises an attachment member for releasably engaging a fluid inlet or outlet, and an elastic member coupled to the attachment member. The attachment device is attachable to a fluid line such... Micromass Uk Limited

Mass spectrometry for determining if a mutated variant of a target protein is present in a sample

A method of mass spectrometry is disclosed for determining if a mutated variant of a target protein is present in a sample. The method comprises subjecting the sample to fragmentation so as to cause said target protein to fragment to form second generation fragment ions, and then mass analysing these... Micromass Uk Limited

Probe adaptor assembly

An apparatus for connecting an ionisation probe assembly to a mass and/or ion mobility spectrometer is disclosed. The apparatus comprises: an attachment member for releasably attaching a probe assembly to the apparatus; a cap for enclosing the attachment member; wherein the apparatus is operable to deliver a voltage to a... Micromass Uk Limited

Interface probe

A GC fitting for an inner tube of a heated transfer line of a gas chromatography interface probe, the fitting comprising a first section comprising a substantially cylindrical projection for fluid connection to a GC source in use, and a second section having a larger radius than the first section... Micromass Uk Limited

Combined mass-to-charge ratio and charge state selection in tandem mass spectrometry

A mass spectrometer is disclosed comprising an ion mobility spectrometer and an ion gate. A collision cell is arranged downstream of the ion gate. The operation of the ion mobility spectrometer and the ion gate are synchronized so that only ions having a particular mass to charge ration and a... Micromass Uk Limited

Accurate mobility chromatograms

A method of mass spectrometry is disclosed comprising: a) separating first ions or components of an analyte sample according to a physicochemical property other than ion mobility; b) separating said first ions or second ions formed from said components according to ion mobility; c) detecting the intensities of said first... Micromass Uk Limited

Fast modulation with downstream homogenisation

A method of mass spectrometry is disclosed involving scanning a parameter of a first device through which a mixture of components is passed. Different components are transmitted through or produced in the first device at different values of the parameter and hence scanning the device parameter introduces a temporal modulation... Micromass Uk Limited

Two-dimensional separation and imaging technique for the rapid analysis of biological samples

A method of ion mapping is disclosed comprising depositing a sample onto a target surface and separating the sample on the target surface according to a first physico-chemical property in a first dimension and according to a second physico-chemical property in a second dimension. The method further comprises ionising and... Micromass Uk Limited

Multi-dimensional survey scans for improved data dependent acquisitions

A method of analysing ions is disclosed comprising performing an initial multi-dimensional survey scan comprising separating parent ions according to a first physico-chemical property (e.g. ion mobility) and then separating the parent ions according to a second physico-chemical property (e.g. mass to charge ratio). A plurality of parent ions of... Micromass Uk Limited

Impactor spray ion source

There is provided an ion source comprising one or more nebulisers and one or more targets, wherein said one or more nebulisers are arranged and adapted to emit, in use, a stream predominantly of droplets which are caused to impact upon said one or more targets and to ionise said... Micromass Uk Limited

Low cross-talk fast sample delivery system based upon acoustic droplet ejection

An ion source for a mass spectrometer is disclosed comprising an ultrasonic transducer which focuses ultrasonic energy onto a surface of a sample fluid without directly contacting the sample fluid.... Micromass Uk Limited

Theoretical collision cross section ("ccs") in experimental design

A method of mass spectrometry is disclosed comprising calculating an ion mobility value, collision cross section or interaction cross section of a plurality of different analyte ions under one or more different analytical conditions, and setting one or more operational parameters of a mass spectrometer in response to the calculated... Micromass Uk Limited

Unknown identification using collision cross section

A method of mass spectrometry is disclosed comprising experimentally determining or measuring one or more first ion mobility values, collision cross sections or interaction cross sections collision cross sections or first ion mobility parameters and one or more mass or mass to charge ratios of one or more analyte ions,... Micromass Uk Limited

Ion source

A method of ionising a sample is provided, comprising providing a fluid sample, wherein the fluid sample contains an analyte, applying one or more pulses of acoustic energy to the fluid sample to cause a spray of the fluid sample to eject from the surface of the fluid sample, and... Micromass Uk Limited

Time of flight mass spectrometer

There is provided a mass spectrometer comprising a time of flight mass analyser comprising an acceleration electrode, a time of flight region and an ion detector, and a control system arranged and adapted (i) to apply a plurality of extraction pulses to said acceleration electrode in order to accelerate consecutive... Micromass Uk Limited

Intelligent dynamic range enhancement

A method of mass spectrometry is disclosed comprising transmitting ions and obtaining first mass spectral data and automatically determining during an acquisition whether the first mass spectral data suffers from saturation or is approaching saturation. If a determination is made during an acquisition that the first mass spectral data suffers... Micromass Uk Limited

Method of introducing ions into a vacuum region of a mass spectrometer

A method of mass spectrometry or ion mobility spectrometry is disclosed. The method comprises providing a spectrometer comprising an orifice between an atmospheric pressure region and a sub-atmospheric pressure region of the spectrometer, wherein the sub-atmospheric pressure region comprises an ion guide or ion trap; providing a sample probe comprising... Micromass Uk Limited

Mobility selective attenuation

A method of mass spectrometry is disclosed comprising separating a first population of ions according to their ion mobility and selectively attenuating ions in the first population of ions in one or more ion mobility and/or drift time ranges so as to form a second population of ions. The step... Micromass Uk Limited

Multipath duty cycle enhancement

A mass spectrometer is disclosed comprising a first device, a second device and a switch arranged and adapted: (i) to direct ions at a first time T1 to the first device and to substantially prevent ions from entering the second device; and (ii) to direct ions at a second later... Micromass Uk Limited

Method for separating ions according to a physicochemical property

A method of separating ions according to a physicochemical property is disclosed. The method comprises causing ions to perform a plurality of cycles along or around an ion guiding path such that the ions separate according to said physicochemical property. The ions are ejected from an ion exit region by... Micromass Uk Limited

Method of mass spectrometry and a mass spectrometer

The present invention relates to a method of mass spectrometry, an apparatus adapted to perform the method and a mass spectrometer. More particularly, but not exclusively, the present invention relates to a method of mass spectrometry comprising the step of associating parent and fragmentation ions from a sample by measuring... Micromass Uk Limited

Histogramming different ion areas on peak detecting analogue to digital convertors

A method of mass spectrometry is disclosed comprising digitising a first signal output from an ion detector to produce a first digitised signal, detecting one or more peaks in the first digitised signal and determining a first area S0 or a first intensity I0 of the one or more peaks... Micromass Uk Limited

Segmented linear ion mobility spectrometer driver

An ion mobility spectrometer or separator is disclosed comprises plural groups of electrodes, each group of electrodes comprising: (i) a first electrode connected to a first independently controllable voltage supply; (ii) one or more intermediate electrodes; and (iii) a second electrode connected to a second independently controllable voltage supply, wherein... Micromass Uk Limited

Hybrid mass spectrometer

A method of mass spectrometry is disclosed comprising separating ions temporally in a first device and analysing the mass or mass to charge ratio of the ions or of product or fragment ions derived from the ions in a mass or mass to charge ratio analyser disposed downstream of the... Micromass Uk Limited

Ion mobility separation device

An ion mobility separator and a method of separating ions according to their ion mobility are disclosed. An RF ion guide is provided having a plurality of electrodes that are arranged to form an ion guiding path that extends in a closed loop. RF voltages are supplied to at least... Micromass Uk Limited

Ion guide

An ion guide is disclosed comprising a first array of electrodes and a second array of electrodes and one or more apertures or ion exit regions. The first array of electrodes comprises a first plurality of arcuate electrodes arranged in parallel with one another and such that said first plurality... Micromass Uk Limited

06/29/17 / #20170184547

Mass spectrometer

A mass spectrometer is disclosed comprising a first ion trap or ion guide, a single ion mobility spectrometer or separator stage and a second ion trap or ion guide arranged downstream of the ion mobility spectrometer or separator. In a mode of operation ions from the second ion trap or... Micromass Uk Limited

06/29/17 / #20170184616

Separating and quantifying thiamine pyrophosphate and pyridoxal 5-phosphate in human whole blood

The present disclosure provides robust, high-throughput, and clinically applicable methods for simultaneously separating and quantifying the biologically active forms of Vitamin B1 (TPP) and Vitamin B6 (PLP) from human whole blood.... Micromass Uk Limited

06/29/17 / #20170186594

Monitoring liquid chromatography elution to determine when to perform a lockmass calibration

A method of mass spectrometry is disclosed that comprises acquiring mass spectral data during a single experimental run or acquisition of a mass spectrometer and determining a first time T during the single experimental run or acquisition for calibrating the mass spectrometer. The step of determining the first time T... Micromass Uk Limited

06/22/17 / #20170176401

Secondary ultrasonic nebulisation

A secondary ultrasonic nebulisation device is disclosed comprising: a liquid sample delivery capillary; a sample receiving surface arranged for receiving a liquid sample from the capillary; and an ultrasonic transducer configured for oscillating the surface so as to nebulise the liquid sample received thereon, wherein the device is configured such... Micromass Uk Limited

06/22/17 / #20170178880

Two dimensional ms/ms acquisition modes

A method of mass spectrometry is disclosed comprising performing a plurality of experimental runs, wherein each experimental run comprises: periodically mass analysing fragment or product ions at a plurality of time intervals, wherein a delay time is provided between the start of the experimental run and the first time interval... Micromass Uk Limited

06/22/17 / #20170178886

Ion guide construction method

A method of constructing an ion guide is disclosed comprising providing an elongated spine member and a plurality of plates. Each plate comprises an aperture therethrough for receiving the spine member and at least one electrode for use in guiding ions. The apertures of the plates are arranged around the... Micromass Uk Limited

06/15/17 / #20170169999

Compact mass spectrometer

A miniature mass spectrometer is disclosed comprising an atmospheric pressure ionisation source and a first vacuum chamber having an atmospheric pressure sampling orifice or capillary, a second vacuum chamber located downstream of the first vacuum chamber and a third vacuum chamber located downstream of the second vacuum chamber. An ion... Micromass Uk Limited

06/08/17 / #20170162374

Improved quadrupole robustness

An apparatus for filtering ions is disclosed comprising a separation device for separating ions temporally according to a first physico-chemical property and a first quadrupole rod set for filtering ions according to their mass to charge ratio, wherein the first quadrupole rod set comprises a plurality of rods and wherein... Micromass Uk Limited

05/25/17 / #20170148615

Mass spectrometer

A hardware module which operatively carries out a method of compressing mass spectral data, the method comprising: receiving a first signal output from an ion detector of a mass spectrometer; processing the first signal to a digital signal at an output being data frame types representative of the first signal... Micromass Uk Limited

05/18/17 / #20170138915

Staggered chromatography mass spectrometry

An analytical instrument is disclosed comprising a liquid chromatography system comprising a first column, a chromatographic delay line and a splitter arranged and adapted in a mode of operation to split eluent from the first column into a first portion of eluent and a second portion of eluent. The instrument... Micromass Uk Limited

05/18/17 / #20170140908

Ion mobility spectrometry data directed acquisition

A method of analysing ions, comprising performing an initial multidimensional survey scan comprising separating parent ions according to a first physico-chemical property and separating said parent ions according to a second physico-chemical property, producing a two-dimensional data set comprising data corresponding to said first physico-chemical property and data corresponding to... Micromass Uk Limited

05/18/17 / #20170140910

Photo-dissociation of proteins and peptides in a mass spectrometer

A method of mass spectrometry is disclosed comprising directing first photons from a laser onto ions located within a 2D or linear ion guide or ion trap. The frequency of the first photons is scanned and first photons and/or second photons emitted by the ions are detected. The ions are... Micromass Uk Limited

05/18/17 / #20170140916

Ion trap with spatially extended ion trapping region

A mass or mass to charge ratio selective ion trap is disclosed which directs ions into a small ejection region. A RF voltage acts to confine ions in a first (y) direction within the ion trap. A DC or RF voltage acts to confine ions in a second (x) direction.... Micromass Uk Limited

05/11/17 / #20170131238

Confirmation using multiple collision cross section ("ccs") measurements

A method of identifying ions or confirming the identity of ions is disclosed comprising determining a physico-chemical or other property of first ions under first conditions, determining the physico-chemical or other property of the first ions or second ions derived from the first ions under second different conditions, and identifying... Micromass Uk Limited

05/11/17 / #20170131290

Fast method to analyse blood samples for the identification of hemoglobin variants using electron transfer dissociation

A method of screening or testing a sample is disclosed that comprises ionising a native human hemoglobin sample to generate parent or precursor ions, subjecting the parent or precursor ions to Electron Transfer Dissociation fragmentation so as to generate a plurality of fragment ions, mass analysing the fragment ions and... Micromass Uk Limited

05/11/17 / #20170133211

Time shift for improved ion mobility spectrometry or separation digitisation

A method of analysing ions is disclosed comprising: (i) separating ions according to a physico-chemical property in a separator; (ii) transmitting ions which emerge from the separator through a transfer device with a first transit time t1, energising a pusher electrode or orthogonal acceleration electrode and obtaining first data; (iii)... Micromass Uk Limited

05/11/17 / #20170133213

Method of transmitting ions through an aperture

A mass spectrometer is disclosed comprising: an ion source; an aperture; a flight region arranged between the ion source and aperture for separating ions according to their mass to charge ratio; and ion optics arranged and configured for causing ions to be reflected or deflected whilst they separate according to... Micromass Uk Limited

05/04/17 / #20170122907

Controlling gas-phase ion interactions

A mass spectrometer or ion mobility spectrometer is disclosed comprising: a first device for separating ions or molecules according to a physicochemical property; an ion mobility separation device for receiving and separating at least some of said ions or ions derived from said molecules according to their ion mobility; a... Micromass Uk Limited

05/04/17 / #20170125222

Self-calibration of spectra using differences in molecular weight from known charge states

A method of calibrating a mass spectrometer is disclosed comprising mass analysing first ions derived from an analyte molecule, wherein the first ions have a first charge state; determining a first mass or mass to charge ratio of the first ions; mass analysing second ions derived from the analyte molecule,... Micromass Uk Limited

05/04/17 / #20170125224

Method of identifying precursor ions

A method of mass spectrometry is disclosed comprising mass selectively transmitting precursor ions from a mass analyser into a fragmentation or reaction device, wherein the mass to charge ratios of the ions transmitted varies with time; fragmenting the precursor ions in the fragmentation or reaction device so as to produce... Micromass Uk Limited

05/04/17 / #20170125225

Method of generating ions of high mass to charge ratio by charge reduction

A method of charge stripping analyte ions is disclosed. The method comprises reacting the analyte ions with reagent ions or charged particles; and then urging the reacted analyte ions through a neutral, inert gas such that said analyte ions interact or collide with the gas molecules in a manner that... Micromass Uk Limited

05/04/17 / #20170125226

Time of flight detection system

A ion detector system for a mass spectrometer is disclosed comprising a detector comprising an array of sensor pixels, wherein a dimension of the sensor pixels is <about 10 μm, and an aperture arranged and adapted such that a beam of charged particles or light passes through the aperture in... Micromass Uk Limited

05/04/17 / #20170125229

Ion entry/exit device

A method of introducing and ejecting ions from an ion entry/exit device (4) is disclosed. The ion entry/exit device (4) has at least two arrays of electrodes (20,22). The device is operated in a first mode wherein DC potentials are successively applied to successive electrodes of at least one of... Micromass Uk Limited

05/04/17 / #20170125231

A compressing an ion beam

A method of mass or ion mobility spectrometry is disclosed comprising: releasing ions from an ion trapping volume into an ion separation region; separating the ions along a longitudinal direction according to a physicochemical property; and compressing the ion beam in a direction orthogonal to the longitudinal axis. The method... Micromass Uk Limited

05/04/17 / #20170125232

Secondary electrospray ionization at reduced pressure

A method of mass spectrometry or ion mobility spectrometry is disclosed comprising: providing gas phase analyte in a vacuum housing; electrospraying a reagent solution outside of the vacuum housing so as to form charged droplets of reagent solution and/or reagent ions; conveying the charged droplets and/or reagent ions into the... Micromass Uk Limited

05/04/17 / #20170125235

Ion profiling with a scanning quadrupole mass filter

A mass spectrometer is disclosed comprising an ion mobility separation device for separating ions according to their ion mobility, a first quadrupole mass filter downstream of the ion mobility separation device, a control system arranged and adapted to scan and/or step the set mass of the first quadrupole mass filter... Micromass Uk Limited

04/27/17 / #20170117125

Liquid extraction matrix assisted laser desorption ionisation ion source

A Matrix Assisted Laser Desorption Ionisation (“MALDI”) ion source is disclosed comprising a first device arranged and adapted to supply a flow of liquid on to the surface of a target or a sample to be analysed so that the liquid forms a liquid junction on the surface of the... Micromass Uk Limited

04/27/17 / #20170117129

Monitoring ion mobility spectrometry environment for improved collision cross section accuracy and precision

A mass spectrometer is disclosed comprising an ion mobility separator for separating ions according to their ion mobility, one or more first devices or stages arranged upstream of the ion mobility separator and a control system. The control system is arranged and adapted to monitor directly or indirectly the operating... Micromass Uk Limited

04/20/17 / #20170110303

Combined tandem mass spectrometry and ion mobility mass spectrometry

A method of analysing ions is disclosed comprising performing an initial multi-dimensional survey scan comprising separating parent ions according to a first physico-chemical property and separating the parent ions according to a second physico-chemical property. At least one parent ion of interest from the initial multi-dimensional survey scan is determined,... Micromass Uk Limited

04/20/17 / #20170110304

Processing mass spectral data

A method of mass spectrometry is disclosed that comprises transforming mass spectral data to produce frequency-domain mass spectral data, modifying the frequency-domain mass spectral data to produce modified frequency-domain mass spectral data by attenuating and/or removing one or more ranges of the frequency-domain mass spectral data that relate to noise... Micromass Uk Limited

Patent Packs
04/20/17 / #20170110310

Synchronised variation of source conditions of an atmospheric pressure chemical ionisation mass spectrometer coupled to a gas chromatograph to improve stability during analysis

A mass spectrometer is disclosed comprising a gas chromatography separation device, an atmospheric pressure ionisation ion source and a control system arranged and adapted: (i) to operate the atmospheric pressure ionisation ion source at one or more first settings for a first period of time whilst one or more solvents... Micromass Uk Limited

04/13/17 / #20170102361

Optimised ion mobility separation timescales for targeted ions

An analytical device for analysing ions is provided comprising a separator for separating ions according to a physico-chemical property and an interface comprising one or more ion guides. A quadrupole rod set mass filter is arranged downstream of the interface. A control system is arranged and adapted: (i) to transmit... Micromass Uk Limited

04/06/17 / #20170098531

Flagging adc coalescence

A method of mass spectrometry is disclosed comprising digitising at least one individual signal or transient, determining in relation to the digitised signal or transient an indication of overlap and/or coalescence of ion arrivals in the digitised signal or transient, or one or more ion arrival envelopes in the digitised... Micromass Uk Limited

03/30/17 / #20170089862

Mass spectrometer

A mass spectrometer is disclosed comprising an ion mobility spectrometer or separator and an ion guide arranged downstream of the ion mobility spectrometer or separator. A plurality of axial potential wells are created in the ion guide so that ions received from the ion mobility spectrometer or separator become confined... Micromass Uk Limited

03/30/17 / #20170092475

Method of generating electron transfer dissociation reagent ions

A method of mass spectrometry is disclosed wherein ions are subjected to an electron detachment, electron capture or electron transfer process in order to form ions having a different charge state. At least some of the ions having a different charge state are caused to interact with analyte ions to... Micromass Uk Limited

03/30/17 / #20170092477

Ion guide

An ion guide comprises a first ion guide portion that forms a first ion guiding path and a second ion guide portion that forms a second ion guiding path. A first device applies a plurality of different first voltages or potentials to the electrodes of the first ion guide portion... Micromass Uk Limited

03/23/17 / #20170082435

Ion source alignment

An ion analysis instrument is disclosed comprising an indicator device for providing an indication of a relative positioning of an ion source, a sample, and/or a sampling orifice or capillary of an ion analysis instrument such as a mass or ion mobility spectrometer in order to facilitate re-alignment of one... Micromass Uk Limited

03/16/17 / #20170076926

De-convolution of overlapping ion mobility spectrometer or separator data

A method of mass spectrometry is disclosed comprising separating first ions according to a first physico-chemical property in a first separator wherein at least some of the first ions undergo a different number of cycles or passes within the separator and separating the first ions which emerge from the first... Micromass Uk Limited

03/16/17 / #20170076927

Using theoretical collision cross section ("ccs") in sample identification

A method of mass spectrometry is disclosed that comprises predicting 1 one or more first reaction products which may result from subjecting an analyte to one or more reactions of interest, calculating 2 one or more first masses or mass to charge ratios and one or more first ion mobility... Micromass Uk Limited

03/16/17 / #20170076929

Multi-dimensional ion separation

A method of mass spectrometry is disclosed comprising separating first ions according to a first physico-chemical property in a first separator wherein at least some of the first ions undergo a different number of cycles or passes within the separator and separating the first ions which emerge from the first... Micromass Uk Limited

03/09/17 / #20170069475

Hybrid acquisition method incorporating multiple dissociation techniques

A method is disclosed wherein parent or precursor ions are fragmented or reacted according to a first fragmentation or reaction mode, and when an ion of interest is detected the method then temporarily switches to a second mode of fragmentation or reaction. This enables a full un-biased MS/MS data set... Micromass Uk Limited

03/09/17 / #20170069477

Ion guide with orthogonal sampling

A mass spectrometer is disclosed comprising a RF ion guide wherein in a mode of operation a continuous, quasi-continuous or pulsed beam of ions is orthogonally sampled from the ion guide and wherein the continuous, quasi-continuous or pulsed beam of ions is not axially trapped or otherwise axially confined within... Micromass Uk Limited

03/09/17 / #20170069478

Glow discharge ion source

A mass spectrometer is disclosed comprising a glow discharge device within the initial vacuum chamber of the mass spectrometer. The glow discharge device may comprise a tubular electrode located within an isolation valve, which is provided in the vacuum chamber. Reagent vapour may be provided through the tubular electrode, which... Micromass Uk Limited

03/09/17 / #20170069479

Ambient ionisation with an impactor spray source

An ion source is disclosed comprising a nebuliser arranged and adapted to emit a liquid spray, a first target arranged downstream of the nebuliser, wherein the liquid spray is arranged to impact upon the first target, and a sample target arranged downstream of the first target, wherein a sample to... Micromass Uk Limited

03/02/17 / #20170059525

Flushing ion mobility separation cell between ion mobility separation cycles

An apparatus is provided to separate ions temporally according to a physico-chemical property comprising an ion guide comprising a plurality of electrodes and a first device arranged and adapted to remove undesired ions remaining within the ion guide after ions of interest have exited the ion guide.... Micromass Uk Limited

Patent Packs
03/02/17 / #20170062197

Mass spectrometer with digital step attenuator

A method is disclosed comprising passing a signal output from a detector through a programmable attenuator or a programmable amplifier prior to digitising the signal, and switching an attenuation factor or gain factor of the programmable attenuator or the programmable amplifier one or more times during a data acquisition period.... Micromass Uk Limited

03/02/17 / #20170062199

Identification and removal of chemical noise for improved ms and ms/ms analysis

A method of mass spectrometry is disclosed comprising mass analysing ions and obtaining mass spectral data and determining parent or precursor ions of interest. The method further comprises determining first adduct or chemical artefact ions which have mass to charge ratios which have a substantially linear relationship with the mass... Micromass Uk Limited

02/23/17 / #20170053785

Mass spectrometer with reduced potential drop

A method of mass spectrometry is disclosed comprising providing a first device and a second device disposed downstream of the first device. The method further comprises introducing a potential difference between the exit of the first device and the entrance of the second device and reducing the total potential drop... Micromass Uk Limited

02/23/17 / #20170053786

Mass spectrometer data acquisition

A data acquisition system for a TOF mass spectrometer comprises a processing module and a data collection module. The processing module generates a stream of data comprising, for each respective transient of a first scan, a set of time-intensity related parameter pairs. For each new set of data, the data... Micromass Uk Limited

02/16/17 / #20170047208

Self-calibration of spectra using precursor mass to charge ratio and fragment mass to charge ratio known differences

A method of checking or adjusting the calibration of a mass spectrometer is disclosed. The method comprises fragmenting parent or precursor ions and generating fragment or product ion mass spectral data and recognising first neutral loss ions in the fragment or product ion mass spectral data. The method further comprises... Micromass Uk Limited

02/16/17 / #20170047211

Method of localizing lipid double bonds

A method of mass spectrometry for analysing lipids and similar biological molecules is disclosed. The lipid molecules may be ionised to form a plurality of lipid parent ions and subjected to photon-induced fragmentation to form a plurality of fragment or product ions. The position of one or more unsaturated bonds... Micromass Uk Limited

02/02/17 / #20170032951

Orthogonal acceleration coaxial cylinder mass analyser

A mass analyser is disclosed comprising an annular ion guide comprising a first annular ion guide section and a second annular ion guide section, wherein the annular ion guide comprises: (i) an inner cylindrical electrode arrangement which is axially segmented and comprises a plurality of first electrodes and (ii) an... Micromass Uk Limited

02/02/17 / #20170032954

High pressure mass resolving ion guide with axial field

A mass spectrometer is disclosed comprising a first mass filter comprising a plurality of electrodes and a first device arranged and adapted to generate an axial force which drives at least some ions axially through or along the first mass filter and a quadrupole mass filter or mass analyser arranged... Micromass Uk Limited

01/26/17 / #20170025260

Controlling hydrogen-deuterium exchange on a spectrum by spectrum basis

A mass spectrometer is disclosed comprising a liquid chromatography device for separating ions. A gas phase ion-neutral reaction device is arranged downstream to perform a gas phase ion-neutral reaction such as Hydrogen-Deuterium exchange. A control system is arranged to automatically and repeatedly switch the reaction device back and forth between... Micromass Uk Limited

01/19/17 / #20170018414

Microwave cavity resonator detector

An ion detector system for a mass spectrometer is disclosed comprising a first device arranged and adapted to receive ions and emit or output first electrons and a microwave cavity resonator arranged and adapted to deflect the first electrons onto a first detector.... Micromass Uk Limited

01/12/17 / #20170011899

Method of optimising spectral data

A method of mass spectrometry or ion mobility spectrometry is disclosed. The method comprises: providing a plurality of species of ions; analysing the ions during a plurality of sequential acquisition periods so as to obtain spectral data relating to the ions; varying the value of an operational parameter of the... Micromass Uk Limited

01/05/17 / #20170003250

Method of charge state selection

A method of mass spectrometry or ion mobility spectrometry is disclosed in which analyte ions of a desired charge state are isolated. The method comprises: separating analytes according to their electrophoretic mobility; ionising the analytes; and mass filtering the resulting analyte ions, wherein the mass to charge ratios of the... Micromass Uk Limited








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