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Miltenyi Biotec Gmbh patents


Recent patent applications related to Miltenyi Biotec Gmbh. Miltenyi Biotec Gmbh is listed as an Agent/Assignee. Note: Miltenyi Biotec Gmbh may have other listings under different names/spellings. We're not affiliated with Miltenyi Biotec Gmbh, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "M" | Miltenyi Biotec Gmbh-related inventors


Automated analysis tool for biological specimens

Systems and methods are described for analyzing a plurality of biological samples with a plurality of fluorescent reagents in an automated fashion. The system may include two optical systems, a fluorescence imaging system and an optical quenching system. ... Miltenyi Biotec Gmbh

Systems and methods for point/center-of-care immunotherapy

A cell modification device, comprising a centrifugation chamber with at least one cell modifying surface with a normal vector having an angle of 135−45° to the rotational axis of the centrifugation chamber, wherein the centrifugation chamber comprises at least one input/output port and the cells to be modified are immobilized at the cell modifying surfaces by the rotation of the centrifugation chamber at 2 to 2000 g. In an embodiment, the device is used as a point-of-care and/or portable device. ... Miltenyi Biotec Gmbh

Composition and method for affecting the binding of antigen-binding polypeptides to antigens

The present invention provides a composition comprising i) a polypeptide comprising calmodulin and two immunoglobulin superfamily domains, wherein said two immunoglobulin superfamily domains are linked via said calmodulin; ii) a calmodulin binding molecule; iii) ions binding to the ca2+ binding site of calmodulin; wherein the binding of said calmodulin-binding molecule and of said ions to said ca2+ binding site of calmodulin affects the binding of said polypeptide to an antigen to be bound by said polypeptide. The calmodulin may be a permutated calmodulin. ... Miltenyi Biotec Gmbh

Preparing antigen-specific t cells using a self-enclosed processing system that contains both a centrifuge and a magnetic separation column

The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder (42), a pump (64) and a plurality of valves (1-11) configured to at least partially control fluid flow through a fluid circuitry and a separation column (40) positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.. . ... Miltenyi Biotec Gmbh

Method and device for suspending cells

The invention is related to a device for suspending particles in a fluid, wherein the mixing device includes a first magnet (1) rotating around a longitudinal axis (2), a mixing rod (4) attached to a mount (6), the mount including a second magnet (3), wherein the mount (6) moves in a substantially orthogonal motion to the longitudinal axis of the mixing rod (4) by the interaction of the rotating first magnet with the second magnet (3).. . ... Miltenyi Biotec Gmbh

Chimeric antigen receptor specific for ssea4 antigen

The present invention provides chimeric antigen receptors (cars) comprising an antigen binding domain specific for ssea4, a population of engineered cells expressing said cars, and a pharmaceutical composition comprising said genetically modified cells expressing said cars. The pharmaceutical composition may be for use of the treatment of cancer in a subject suffering from cancer, wherein at least a subpopulation of the cancerous cells of said cancer expresses ssea4.. ... Miltenyi Biotec Gmbh

Cell population for use in treting cancer

The invention pertains to a cell population for use in treating cancer in a patient, comprising cd1c (bdca-1)+/cd19− dendritic cells, wherein cd1c(bdca-1)+/cd19− dendritic cells are depleted for cd1c (bdca-1)+/cd197cd14+ cells.. . ... Miltenyi Biotec Gmbh

Miltenyi Biotec Gmbh

. . ... Miltenyi Biotec Gmbh

Method for generation of a cell composition of mesencephalic dopaminergic progenitor cells

The present invention provides a method for generation of a cell composition of mesencephalic dopaminergic progenitor cells from a starting cell composition comprising pluripotent and/or multipotent stem cells, the method comprising the steps of a) differentiating said pluripotent and/or multipotent stem cells into mesencephalic dopaminergic progenitor cells, thereby generating a cell population comprising mesencephalic dopaminergic progenitor cells and other cells, b) dissociating the differentiated cells of step a) into a single cell suspension, and c) enriching said mesencephalic dopaminergic progenitor cells by using an antigen binding molecule specific for the cd47 antigen for positive selection of said mesencephalic dopaminergic progenitor cells in said single cell suspension. Said method may be performed in a closed cell sample processing system and may be performed in an automated manner.. ... Miltenyi Biotec Gmbh

Automated analysis tool for biological specimens

Systems and methods are described for analyzing a plurality of biological samples with a plurality of fluorescent reagents in an automated fashion. The system may include two optical systems, a fluorescence imaging system and an optical quenching system. ... Miltenyi Biotec Gmbh

Miltenyi Biotec Gmbh

. . ... Miltenyi Biotec Gmbh

Self-contained disposable tubing set for sterile preparation of cells by culturing, centrifugation, and column chromatography

The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder (42), a pump (64) and a plurality of valves (1-11) configured to at least partially control fluid flow through a fluid circuitry and a separation column (40) positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.. . ... Miltenyi Biotec Gmbh

Method for identifying and obtaining activated t-cells that have a demethylated foxp3 tsdr region

This disclosure provides a method of identifying or separating activated regulatory t cells that have a demethylated foxp3 tsdr region from a mixture of activated t cells. The mixture is depleted of cells bearing the cd154 molecule (cd40 ligand). ... Miltenyi Biotec Gmbh

Miltenyi Biotec Gmbh

. . ... Miltenyi Biotec Gmbh

03/02/17 / #20170059458

Process for sorting cells by microfabricated components using a nuclease

The invention is directed to a process for sorting target cells and non-target cells from a sample by a cell sorting valve microfabricated on a surface of a silicon substrate, with microfabricated channels leading from the cell sorting valve, wherein the cell sorting valve separates the target particles from non-target material; a disposable cartridge containing a sample reservoir, a sort reservoir and a waste reservoir; wherein the sample is provided in a buffer comprising nuclease.. . ... Miltenyi Biotec Gmbh

02/09/17 / #20170037370

Method for automated generation of genetically modified t cells

The present invention provides a process for generation of genetically modified t cells, t cell subsets and/or t cell progenitors comprising the steps: a) providing a cell sample comprising t cells, t cell subsets and/or t cell progenitors b) preparation of the cell sample by centrifugation c) magnetic separation of the t cells, t cell subsets and/or t cell progenitors d) activation of the enriched t cells, t cell subsets and/or t cell progenitors using modulatory agents e) genetic modification of the t cells, t cell subsets and/or t cell progenitors f) expansion of the genetically modified t cells, t cell subsets and/or t cell progenitors in a cultivation chamber g) washing of the cultured t cells, t cell subsets and/or t cell progenitors characterized in that all steps are performed in a closed and sterile cell culture system.. . ... Miltenyi Biotec Gmbh








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