Mimedx Group Inc patents

Kits and materials for implantable collagen devices

The invention relates to implantable collagen devices made by seeding at least one elongate collagen construct, e.g., comprising at least one elongate synthetic collagen fiber with a plurality of cells and applying a strain and/or stress to the at least one elongate collagen fiber to induce the cells to differentiate into target phenotypes, e.g., tendon or ligament phenotype cells (and/or fibroblasts), typically with an extracellular matrix of collagen to organize into a tissue on the at least one collagen fiber.. . ... Mimedx Group Inc

Non-surgical, localized delivery of compositions for placental growth factors

Described herewith are compositions comprising placental growth factors and methods for non-surgical, localized delivery thereof. The composition is delivered to a diseased or injured organ and/or body part and is formulated in a manner which allows for localized retention of the composition at the site of delivery.. ... Mimedx Group Inc

Placental tissue grafts and improved methods of preparing and using the same

Described herein are tissue grafts derived from the placenta. The grafts are composed of at least one layer of amnion tissue where the epithelium layer has been substantially removed in order to expose the basement layer to host cells. ... Mimedx Group Inc

Placental tissue grafts and improved methods of preparing and using the same

A method for preparing placenta membrane tissue grafts for medical use, includes obtaining a placenta from a subject, cleaning the placenta, separating the chorion tissue from the amniotic membrane, mounting a selected layer of either the chorion tissue or the amniotic membrane onto a drying fixture, dehydrating the selected layer on the drying fixture, and cutting the selected layer into a plurality of tissue grafts. Preferably, the drying fixture includes grooves or raised edges that define the outer contours of each desired tissue graft, after they are cut, and further includes raised or indented logos that emboss the middle area of the tissue grafts during dehydration and that enables an end user to distinguish the top from the bottom side of the graft. ... Mimedx Group Inc

Synthetic collagen threads for cosmetic uses including skin wrinkle treatments and associated methods

Cosmetic threads for reducing wrinkle size include at least one synthetic collagen fiber that wells after placement under the skin.. . ... Mimedx Group Inc

Placental tissue grafts produced by chemical dehydration/freeze-drying and methods for making and using the same

Described herein are placental tissue grafts produced by chemical dehydration followed by freeze-drying the placental tissue to produce the tissue graft. The tissue grafts retain their biological properties preferably at the same level as the placental tissues before they are processed. ... Mimedx Group Inc

Biostaples suitable for wrist, hand and other ligament replacements or repairs

The disclosure describes implantable medical products, that include dry or partially hydrated biocompatible biostaples suitable for ligament repairs or replacements comprising collagen fibers that may be configured to expand in situ after implantation to frictionally engage a bone tunnel wall or bone sleeve to thereby affix the construct in the bone tunnel.. . ... Mimedx Group Inc

Collagen fiber ribbons with integrated fixation sutures and methods of making the same

The disclosure describes implantable bioprosthesis and constructs having an implantable woven ribbon with at least one integrated suture.. . ... Mimedx Group Inc

Placental tissue grafts and methods of preparing and using the same

A method for preparing placenta membrane tissue grafts for medical use, includes obtaining a placenta from a subject, cleaning the placenta, separating the chorion tissue from the amniotic membrane, mounting a selected layer of either the chorion tissue or the amniotic membrane onto a drying fixture, dehydrating the selected layer on the drying fixture, and cutting the selected layer into a plurality of tissue grafts. Preferably, the drying fixture includes grooves or raised edges that define the outer contours of each desired tissue graft, after they are cut, and further includes raised or indented logos that emboss the middle area of the tissue grafts during dehydration and that enables an end user to distinguish the top from the bottom side of the graft. ... Mimedx Group Inc

Cross-linked dehydrated placental tissue grafts and methods for making and using the same

Described herein are tissue grafts produced by contacting dehydrated placental tissue grafts with a cross-linking agent. The tissue grafts described herein provide barrier and prevent the migration of a bioactive agent from the wound. ... Mimedx Group Inc