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Morphotek Inc
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Morphotek Inc patents


Recent patent applications related to Morphotek Inc. Morphotek Inc is listed as an Agent/Assignee. Note: Morphotek Inc may have other listings under different names/spellings. We're not affiliated with Morphotek Inc, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "M" | Morphotek Inc-related inventors


Methods for treating lung cancer

Provided herein are methods for predicting a likelihood of responsiveness to treatment with a folate receptor alpha (fra)-targeting agent in a patient having a fra-expressing lung cancer. Also provided are methods for treating a fra-expressing lung cancer in a patient with a fra-targeting agent. ... Morphotek Inc

High affinity antibodies that neutralize staphylococcus enterotoxin b

Provided herein are antibodies that specifically bind and neutralize staphylococcus enterotoxin b. In addition, nucleic acids encoding such antibodies, and cells that express such antibodies are provided. ... Morphotek Inc

Tem-1 diagnostic antibodies

Described herein are anybodies, and antigen-binding fragments thereof, that are specific for tumor endothelial marker 1 (tem-1), related polynucleotides, expression vectors, and cells that express the described antibodies. Also provided are methods of using the described antibodies, and antigen-binding fragments thereof, and related kits. ... Morphotek Inc

Chlorotoxin polypeptides and conjugates and uses thereof

Reduced lysine chlorotoxin polypeptides that may be used to generate single species conjugates of chlorotoxin. Conjugates comprising such chlorotoxin polypeptides and pharmaceutical compositions thereof. ... Morphotek Inc

Eribulin-based antibody-drug conjugates and methods of use

Linker toxins and antibody-drug conjugates that bind to human oncology antigen targets such as folate receptor alpha and/or provide anti-tubulin drug activity are disclosed. The linker toxins and antibody-drug conjugates comprise an eribulin drug moiety and can be internalized into target antigen-expressing cells. ... Morphotek Inc

Monoclonal antibodies that specifically block biological activity of a tumor antigen

This invention relates to novel monoclonal antibodies that specifically bind to the alpha-folate receptor. In some embodiments, the antibodies inhibit a biological activity of folate receptor-α (fr-α). ... Morphotek Inc

Methods for treatment of gastric cancer

The application provides methods of detection, diagnosis, prognosis, prophylaxis and treatment of folate receptor-alpha-expressing gastric cancer using antibodies that specifically bind to folate receptor alpha.. . ... Morphotek Inc

High affinity antibodies that neutralize staphylococcus enterotoxin b

Provided herein are antibodies that specifically bind and neutralize staphylococcus enterotoxin b. In addition, nucleic acids encoding such antibodies, and cells that express such antibodies are provided. ... Morphotek Inc

Antibodies with immune effector activity and that internalize in folate receptor alpha-positive cells

This invention relates to the use of monoclonal and polyclonal antibodies that specifically bind to and have the ability in the alternative to become internalized by cells expressing folate receptor alpha (fra) and to induce an immune effector activity such as antibody-dependent cellular cytotoxicity. The antibodies are useful in specific delivery of pharmacologic agents to fra-expressing cells as well as in eliciting an immune-effector activity particularly on tumor cells and precursors. ... Morphotek Inc

Methods for inhibiting the binding of endosialin to ligands

The invention provides methods for inhibiting the interaction of endosialin with endosialin ligands. The inhibition is effectuated on the genetic level, by inhibiting endosialin gene expression, and on the protein level, by blocking the interaction of cell-surface expressed endosialin with ligands such as fibronectin and collagen. ... Morphotek Inc








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