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National Research Council Of Canada patents


Recent patent applications related to National Research Council Of Canada. National Research Council Of Canada is listed as an Agent/Assignee. Note: National Research Council Of Canada may have other listings under different names/spellings. We're not affiliated with National Research Council Of Canada, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "N" | National Research Council Of Canada-related inventors


Lipidated streptococcus pneumoniae antigen compositions, methods of preparation and use

There are provided compositions and methods for prevention or treatment of Streptococcus pneumoniae (SP)-associated diseases. More specifically, there are provided recombinant lipidated fusion proteins comprising pneumococcal surface antigen A (PsaA), the recombinant lipidated fusion proteins comprising, from N-terminus to C-terminus, the N-terminal native lipid signal peptide of PsaA and the... National Research Council Of Canada

Dynamic security device

A security device that elicits at least one dynamic response upon acceleration, or upon change of orientation with respect to gravity, wherein the dynamic response continues after cessation of the acceleration or the change of orientation. In addition, the dynamic response can be optical, such that it is visually observable... National Research Council Of Canada

Co-extruded ultra thin films

A process for producing an ion exchange precursor resin membrane involves co-extruding an ion exchange precursor resin with an incompatible polymer to form a multilayer film having a layer of the ion exchange precursor resin supported on a layer of the incompatible polymer. The layer of incompatible polymer is then... National Research Council Of Canada

Alignment and rotation of janus microparticles in response to acceleration

Gravitational Janus microparticle having, a center-of-mass, a center-of-volume, and a non-uniform density, wherein: the center-of-mass and the center-of-volume are distinct. When suspended in a fluid, the microparticle substantially aligns with either: i) the gravitational field; or ii) the direction of an acceleration, such that the Janus microparticle is in substantial... National Research Council Of Canada

Novel neisseria gonorrhoeae therapeutic based on cmp-nonulosonate sugars

N. gonorrhoeae has become resistant to almost every conventional antibiotic. Described herein is the use of CMP-nonulosonate analogues to counter gonococcal complement evasion. The nonulosonate sugar is incorporated into the lipooligosaccharide of the N. gonorrhoeae which in turn reduces the serum resistance of the bacteria. This provides a novel therapeutic... National Research Council Of Canada

Microparticles and smart ink production

A smart ink, comprising microparticles, with each microparticle comprising: a) an exterior shell; b) a liquid encapsulated within the shell; and c) a Janus microparticle suspended in the liquid, wherein the Janus microparticle either comprises: i) two or more distinct assemblies of particles; or ii) a core loaded with particles,... National Research Council Of Canada

Human blood brain barrier model

An in vitro population of human brain endothelial cells (hBECs) expressing claudin-5, occludin, ZO-1 and GLUT-1 and expressing one or more of FZD7, WNT7A, WNT7B, APCDD1, STRA6 and ZO-3 is provided. A blood brain barrier (BBB) comprising the hBECs and use of the BBB for analyzing permeability characteristics of a... National Research Council Of Canada

Multi-domain enzymes having cutinase activity, compositions comprising same and uses thereof

An isolated chimeric recombinant protein has cutinase activity. The protein includes a cutinase catalytic domain and a polymer binding domain operably linked by a proline/threonine-rich linker domain. The proline/threonine-rich linker domain includes at least 50% proline or threonine residues over a stretch of 15 to 55 consecutive amino acids.... National Research Council Of Canada

Radiation shielding composition and making the same

Described herein is a radiation shielding composition and a method for making comprising: (i) a boron-containing powder wherein the boron-containing powder comprises at least a bimodal particle size distribution, and (ii) a metal, wherein the metal encapsulates the ceramic powder to form the radiation shielding composition.... National Research Council Of Canada

Anti-tau antibody and uses thereof

The present invention relates to Tau-specific antibodies, fragments thereof, and uses thereof. More specifically, the present invention relates to Tau-specific antibodies, fragments thereof, and conjugates thereof with conjugated to a superparamagnetic nanoparticle. The molecules of the present invention may be used in visualizing damage from traumatic brain injury.... National Research Council Of Canada

Pattenred film for forming fluid-filled blister, microfluidic blister, and kit and forming

A patterned thermoplastic elastomer (TPE) film for fabricating a liquid-filled blister, has a blister-sized cavity in fluid communication with a microfluidic channel via a gating region. The gating region is defined by a relief pattern that has at least one of the following: at least 5 separate compartments defined by... National Research Council Of Canada

Titanium-based compositions, methods of manufacture and uses thereof

Titanium-based compositions as well as titanium composites such as carbide-reinforced titanium composites are disclosed herein. More specifically, composite materials comprising a titanium metal matrix and titanium carbide dispersed in the matrix are disclosed. The composite materials comprise about 0.5 wt. % to about 3.0 wt. % of carbon, based on... National Research Council Of Canada

Boron nitride nanotubes and process for production thereof

... National Research Council Of Canada

Pressing magnetic resonance imaging and spectroscopy

A magnetic resonance (MR) apparatus, the MR apparatus including a tissue pressing surface having one or more MR coil elements, the pressing surface being configured and sized to selectively indent a portion of an exterior tissue of a subject when a physical force is applied to the indenting substrate thereby... National Research Council Of Canada

Anti-clusterin antibodies and antigen binding fragments and their use to reduce tumor volume

Novel antibodies and antigen binding fragments that specifically bind to clusterin are described. In some embodiments, the antibodies block the biological activity of clusterin and are useful in composition in certain cancers, more particularly in cancers, such as endometrial carcinoma, breast carcinoma, hepatocellular carcinoma, prostate carcinoma, a renal cell carcinoma,... National Research Council Of Canada

Genes and proteins for aromatic polyketide synthesis

Nucleic acid molecules encoding polypeptides having polyketide synthase activity have been identified and characterized. Expression or over-expression of the nucleic acids alters levels of cannabinoid compounds in organisms. The polypeptides may be used in vivo or in vitro to produce cannabinoid compounds.... National Research Council Of Canada

Method of forming pressure pad or other flexible element for use during cure of composite materials

A method of manufacturing a flexible element configured for pressing against composite material received on a mold surface of a mold during cure, including placing a porous material over the mold surface, forming a sealed enclosure containing the mold surface and the porous material, infusing a curable liquid material such... National Research Council Of Canada

Process for producing ion exchange membranes by melt-processing of acidic pfsa ionomers

A process for producing an ion exchange membrane involves melt-processing a mixture of a perfluorosulfonic acid ionomer in its acid form and a specific azole additive. The additive may be a triazole, alkyl triazole, vinyl triazole, fluoro-alkyl triazole, fluoro-vinyl triazole, pyrazole, alkyl pyrazole, vinyl pyrazole, fluoro-alkyl pyrazole, fluoro-vinyl pyrazole, benzimidazole,... National Research Council Of Canada

Animal models, cell lines and methods for screening hepatitis c virus vaccines

Modified non-human mammalian hepatoma cell lines that express hepatitis C virus (HCV) antigens and which are capable of generating tumours in a syngeneic animal model are provided. The cell lines are generated by genomic integration of an expression construct that comprises one or more HCV antigen-encoding sequences under the control... National Research Council Of Canada

Bi-layer iron coating of lightweight metallic substrate

A wear resistant friction coating (WRFC) can be applied on a lightweight metallic substrate, by applying a cold gas dynamic spray bond coat containing more iron than any other single element directly onto a surface of the substrate, and thermal spraying the WRFC coating over the bond coat to a... National Research Council Of Canada

Method for laser-induced breakdown spectroscopy and calibration

A method for laser induced breakdown spectroscopy (LIBS) calibration or LIBS assay comprises providing a plurality of reference samples, each having a respective, known concentration of an analyte, assaying each reference sample to obtain a respective LIBS spectrum, and for each reference LIBS spectrum, measuring an intensity of at least... National Research Council Of Canada

Ultrasonic transducer assembly and system for monitoring structural integrity

In an ultrasonic transducer assembly, a conformable ultrasonic transducer has a piezoelectric layer and electrodes able to conform to curved surfaces, and a clamp for pressing the transducer into ultrasonic contact with a curved surface. Conformability is ensured with a thin, porous piezoelectric layer and suitable electrical conductors and insulators.... National Research Council Of Canada

Forming an optical grating with an apparatus providing an adjustable interference pattern

An apparatus for use with a pulsed laser source for forming an optical grating in a target includes an adjustable telescope having an element with a negative optical power, for generation of a diverging optical beam, so that the optical beam has adjustable divergence upon exiting the telescope while focusing... National Research Council Of Canada

Use of xanthan gum as an anode binder

Xanthan gum has been found to be a superior binder for binding an electrode, especially an anode, in a lithium-ion or lithium-sulfur battery, being able to accommodate large volume changes and providing stable capacities in batteries tested with different types of anode materials.... National Research Council Of Canada

Swivel mount for centrifugal microfluidic chip

A centrifugal microfluidic chip mounting, kit and method include a swivel joint permitting a chip to rotate about an axis of the chip in a plane swept by a centrifuge, and a force applicator for controlling an angle of the swivel and for applying a force in proportion to a... National Research Council Of Canada

Recombinant bacterium and uses thereof

The present invention relates to a recombinant bacterium expressing an antigen that is translocated to the cytosol of a host organism, and uses thereof. To this end, the present invention provides a recombinant bacterium comprising a nucleic acid encoding an antigen that is translocated to the cytosol of a host... National Research Council Of Canada

Method and fast quantitative analysis of a material by laser induced breakdown spectroscopy (libs)

The invention discloses an apparatus and method for use with Laser Induced Breakdown Spectroscopy (LIBS) systems that can be applied to the real time analysis of various materials. The invention, in one aspect, provides a layer-by-layer method to remove the undesired coating layer of a material in which a pulsed... National Research Council Of Canada

Sulfated-glycolipids as adjuvants for vaccines

A synthetic charged glycolipid is described comprising a sulfated saccharide group covalently linked to the tree sn-1 hydroxyl group of the glycerol backbone of an archaeal core lipid via a beta linkage. The synthetic charged glycolipids include compounds of formula I wherein n is 0 or 1; R is hydrogen... National Research Council Of Canada

Boron nitride nanotubes and process for production thereof

... National Research Council Of Canada

Cell-based production of nonulosonates

The present invention relates to the cell-based production of bacterial nonulosonates and their biosynthetic precursors. Specifically, the present invention provides recombinant cells for the production of pseudaminic acid, legionaminic acid, UDP-2,4-diacetamido-2,4,6-trideoxy-β-L-altropyranose, and UDP-2,4-diacetamido-2,4,6-trideoxy-α-D-glucopyranose. Methods for producing the sugars are also provided.... National Research Council Of Canada

H. pylori lipopolysaccharide outer core epitope

wherein R is a α-DDHep-3-α-L-Fuc-3-β-GlcNAc trisaccharide substituted with an α1,6-glucan linked to an α1,3-DD-heptan, and wherein the last DD-Hep residue of α1,3-DD-heptan is capped with β-GlcNAc residue. Compositions comprising the compound, uses of the compound, and antibodies raised against the compound are also described.... National Research Council Of Canada

Molecular inks

A flake-less molecular ink suitable for printing (e.g. screen printing) conductive traces on a substrate has 30-60 wt % of a C8-C12 silver carboxylate or 5-75 wt % of bis(2-ethyl-1-hexylamine) copper (II) formate, bis(octylamine) copper (II) formate or tris(octylamine) copper (II) formate, 0.1-10 wt % of a polymeric binder (e.g.... National Research Council Of Canada

Screening of protein candidates

Successful application of an engineered protein as therapeutics or in other industries would require the protein to have good expression level, good biophysical properties and often desired affinity to its target. The present invention provides s method of screening large numbers of protein candidates (PCs) in all three aspects simultaneously.... National Research Council Of Canada

Oscillating foil turbine

An oscillating foil turbine has a foil having a first fluid dynamic surface for producing lift in a fluid flow, a support for the foil, and a second fluid dynamic surface, wherein the support allows for cyclic motion of the first and second surfaces with respect to each other. A... National Research Council Of Canada

Retention index standards for liquid chromatography

A liquid chromatography method for identifying an analyte of interest utilizing as retention index standards a homologous series of neutrally charged compounds having at least one functional group bearing a positive charge and at least one functional group bearing a negative charge. The method is especially useful for liquid chromatography-mass... National Research Council Of Canada

03/30/17 / #20170087593

Porosity control in piezoelectric films

A piezoelectric film having a porosity between 20 and 40%, a thickness ranging from tens of microns to less than a few millimeters can be used to form an ultrasonic transducer UT for operation in elevated temperature ranges, that emit pulses having a high bandwidth. Such piezoelectric films exhibit greater... National Research Council Of Canada

03/09/17 / #20170066872

Carboxylic acid or acid salt functionalized polyester polymers

The present disclosure describes a polyester that contains plural pendant adjacent carboxylic acid or acid salt side groups for use in making a toner for use in imaging devices.... National Research Council Of Canada

03/02/17 / #20170057899

Efficient scalable syntheses of abscisic acid, 8'-acetylene abscisic acid and 8'-cyclopropyl abscisic acid

Methods are provided for synthesis of abscisic acid and 8′ analogues thereof (including an enantiopure 8′-acetylene analogue) including methods wherein the previously reported first step of oxidation of 2,6-dimethylphenol (VI) to 2,6-dimethylbenzoquinone, mono ketal (VII) is replaced by a novel two step process comprising (i) oxidation of 2,6-dimethylphenol (VI) using... National Research Council Of Canada

02/16/17 / #20170044238

Engineering of immunoglobulin domains

The present invention provides a single domain antibody (sdAb) scaffold comprising one or more than one non-canonical disulfide bond in the framework region (FR). The one or more than one non-canonical disulfide bond may be formed between cysteines introduced by mutations in FR2 and FR3. In the case where the... National Research Council Of Canada

02/16/17 / #20170044289

Radiation curable polymer formulation and methods for the preparation thereof

Disclosed is a radiation curable polymer formulation and methods of producing a dielectric film having such a formulation. The radiation curable polymer formulation includes an acrylic monomer; a cross linking agent; and a photoinitiator. The polymer formulation is insoluble with an organic solvent, which is preferable in low cost high... National Research Council Of Canada

02/16/17 / #20170045404

Air sensor with downstream facing ingress to prevent condensation

An air flow sensor is provided with an opening facing downstream and having a thin downstream facing edge to prevent condensation or buildup of moisture thereon. The sensor has been found to reduce entrainment of particles in a mixed phase stream. The sensor is suitable for mounting to an aircraft,... National Research Council Of Canada

02/09/17 / #20170036208

Centrifugal microfluidic chip control

A technique is provided for incorporating pneumatic control in centrifugal microfluidics. The technique involves providing a chip controller that has pressurized fluid supply lines for coupling one or more pressurized chambers of the controller with ports of a microfluidic chip. At least part of the chip controller is mounted to... National Research Council Of Canada

02/02/17 / #20170027888

Use of catecholamines and related compounds as anti-angiogenic agents

The present invention provides a pharmaceutical composition comprising at least one compound selected from the group consisting of (S)-isoproterenol, (S)-isoproterenol dipivalate, (S)—N-ethylnoradrenaline, (S)—N-n-Propylnoradrenaline, (S)—N-Butylnoradrenaline, (R, S)—N-tert-butylnoradrenaline, 1-(3, 4) dihydrooxylphenyl)-2-(isopropylamine)-1-(R, S)-butanol, (S)-1-(N-isopropyl)-3-methyldopamine and (R)-1-(N-isopropyl)-3-methyldopamine suitable. The pharmaceutical composition may be for topical application to ocular tissues.... National Research Council Of Canada

02/02/17 / #20170027889

Use of catecholamines and related compounds as anti-angiogenic agents

a physiologically tolerated salt thereof, a prodrug thereof, a physiologically functional derivative thereof or any mixture thereof as an anti-angiogenic agent. The anti-angiogenic agent should have greater lipophilicity than (S)-noradrenaline.... National Research Council Of Canada

01/26/17 / #20170022277

Insulin-like growth factor 1 receptor -specific antibodies and uses thereof

The blood-brain barrier (BBB) prevents transport of molecules larger than 500 Dal tons from blood to brain. Receptor-mediated transcytosis (RMT) facilitates transport across the BBB of specific molecules that bind receptors on brain endothelial cells that form the BBB. An insulin-like growth factor 1 receptor (IGF 1R)-binding antibody or fragment... National Research Council Of Canada

01/19/17 / #20170015748

Insulin-like growth factor 1 receptor -specific antibodies and uses thereof

The blood-brain barrier (BBB) prevents transport of molecules larger than 500 Dal tons from blood to brain. Receptor-mediated transcytosis (RMT) facilitates transport across the BBB of specific molecules that bind receptors on brain endothelial cells that form the BBB. An insulin-like growth factor 1 receptor (IGF 1R)-binding antibody or fragment... National Research Council Of Canada

01/19/17 / #20170015749

Insulin-like growth factor 1 receptor -specific antibodies and uses thereof

The blood-brain barrier (BBB) prevents transport of molecules larger than 500 Daltons from blood to brain. Receptor-mediated transcytosis (RMT) facilitates transport across the BBB of specific molecules that bind receptors on brain endothelial cells that form the BBB. An insulin-like growth factor 1 receptor (IGF1R)-binding antibody or fragment thereof is... National Research Council Of Canada

07/27/17 / #20170211049

Cannabichromenic acid synthase from cannabis sativa

Nucleic acid molecules from cannabis have been isolated and characterized and encode polypeptides having cannabi-chromenic acid synthase activity. Expression or over-expression of the nucleic acids alters levels of cannabinoid compounds. The polypeptides may be used in vivo or in vitro to produce cannabinoid compounds.... National Research Council Of Canada








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