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National University Of Singapore patents


Recent patent applications related to National University Of Singapore. National University Of Singapore is listed as an Agent/Assignee. Note: National University Of Singapore may have other listings under different names/spellings. We're not affiliated with National University Of Singapore, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "N" | National University Of Singapore-related inventors


 new patent  Methods for enhancing efficacy of therapeutic immune cells

The present invention relates to a method of using a receptor (e.g., chimeric antigen receptor—CAR) that activates an immune response upon binding a cancer cell ligand in conjunction with a target-binding molecule that targets a protein or molecule CI for removal or neutralization to generate enhanced anti-cancer immune cells. The... National University Of Singapore

 new patent  Fillers for polymers

This invention relates to a composite material comprising a core comprising an organosilica such as a polyhedral oligomeric silsesquioxane (POSS) and a functionalized elastomeric polymer such as poly(n-butyl acrylate) bonded onto said core. The elastomer is preferably functionalised with an amine moiety. The present invention also relates to a polymer... National University Of Singapore

Convex contact probe for the delivery of laser energy

Systems, devices, and methods for treating a glaucomatous eye are provided. Embodiments may provide a treatment probe for treating an eye of a patient. The treatment probe may have an elongate body with a contact surface at a distal end of the elongate body. A treatment fiber or light source... National University Of Singapore

A monitoring and/or assessing pupillary responses

The present invention relates to a method for monitoring and/or assessing pupillary responses to a continuous illumination of light starting at a first intensity which is gradually changed to subsequent intensity over a predefined period of time. The method may be used to detect aberrant pupillary responses. Also included is... National University Of Singapore

Light-activated two-component protein binding matrix

A binding pair for chromatographic separation or purification of a molecule of interest, where one binding member of the pair is an isomerizable organic molecule and the other binding member of the pair is an isomer-specific affinity agent bound to a molecule of interest. The binding pair associates and disassociates... National University Of Singapore

Data processing in cache coherence directory architecture

The embodiment of the disclosure discloses a data processing method and device in a cache coherence directory architecture. The method includes that allocating a tag entry in a tag array for a data block; allocating a data entry in a data array for the data block when the data block... National University Of Singapore

Method and device for real-time error-bounded and delay-bounded map matching

Method and device for real-time error bounded and relay bounded map matching. The method for map matching comprises of modelling each road arc as a hidden state and each location measurement as an observation emitted by the hidden state using a Hidden Markov Model, decoding each road arc and each... National University Of Singapore

Manufacture of a pharmaceutical product

An emulsion-based method for the manufacture of a crystalized spherical agglomerate and/or a pharmaceutical product is provided; and crystalized spherical agglomerates and/or pharmaceutical products manufactured thereby.... National University Of Singapore

Chimerization and characterization of a monoclonal antibody with potent neutralizing activity across multiple influenza a h5n1 clades

MAb 9F4 provides heterologous protection against multiple influenza A H5N1 clade viruses, including one of the recently designated subclades, namely 2.3.4, through binding to a novel epitope. The present invention relates to isolated mouse-human chimeric (xi) IgG1-9F4 and IgA1-9F4 MAb which retain high degrees of binding and neutralizing activity against... National University Of Singapore

Stent graft device

The present disclosure relates to stent graft devices for endovascular repair of aneurysms. A stent graft device according to the present disclosure comprises: a membrane defining a lumen between a proximal end and a distal end of the membrane, the lumen for fluid communication distally therethrough; a plurality of fenestrations... National University Of Singapore

System and inertial focusing microfiltration for intra-operative blood salvage autotransfusion

A system for intra-operative blood salvage autotransfusion is provided. The system comprises at least one inlet configured to receive whole blood of a patient; at least one curvilinear microchannel in fluid flow connection with the at least one inlet, the at least one curvilinear microchannel being adapted to isolate circulating... National University Of Singapore

Highly dense nano-carbon foam with controlled porosity synthesized from hollow carbon nanoparticles

Hot pressing hollow carbon nanoparticles results in a nano-carbon foam that can be used for energy storage, carbon dioxide capture or water desalination.... National University Of Singapore

Magnetic stack including crystallized segregant induced columnar magnetic recording layer

A stack includes a substrate, a magnetic recording layer having a columnar structure, and an interlayer disposed between the substrate and the magnetic recording layer. The columnar structure includes magnetic grains separated by a crystalline segregant or a combination of crystalline and amorphous segregants.... National University Of Singapore

Microfluidic perfusion bioreactor cell retention

A microfluidic system for cell retention for a perfusion bioreactor is provided. The system comprises at least one inlet configured to receive a bioreaction mixture to be processed. At least one curvilinear microchannel is in fluid flow connection with the at least one inlet, the at least one curvilinear microchannel... National University Of Singapore

Catalytic membrane system for converting biomass to hydrogen

A two-reactor catalytic system including a catalytic membrane gasification reactor and a catalytic membrane water gas shift reactor. The catalytic system, for converting biomass to hydrogen gas, features a novel gasification reactor containing both hollow fiber membranes that selectively allow O2 to permeate therethrough and a catalyst that facilitates tar... National University Of Singapore

Molecular tunnel junctions and their use as sources of electronic plasmons

A method of producing electronic plasmons by applying a bias to a molecular tunnel junction to excite plasmons, in which the molecular tunnel junction contains a top metallic electrode formed of a eutectic metal alloy and a metal oxide, a bottom metallic electrode formed of a transition metal, and a... National University Of Singapore

Magnetization-switching magnetic system

A magnetic system containing a plurality of stacked layer arrays, each of which includes a first anti-ferromagnetic (AFM1) layer, a heavy metal (HM) layer formed of a material having strong spin-orbit coupling, and, optionally, a ferromagnetic (FM) layer or a second anti-ferromagnetic (AFM2) layer. Also disclosed is a method of... National University Of Singapore

Single-stage multi-string led driver with dimming

A driver circuit for light emitting diodes (LEDs) and a driving method for LEDs. The driver circuit comprises a single stage DC-DC converter with multiple output channels, the converter comprising one set of switches on a primary side of the converter, a rectifier and voltage multiplier component at the secondary... National University Of Singapore

Cationic polyamines for treatment of viruses

Antiviral cationic polyamines were prepared by modifying polyethylenimines with N-acylating agents that introduce a side chain comprising one or more carbons and at least one alcohol hydroxy group. The cationic polyamines can have a linear or branched polyethylenimine backbone structure. Preferably, the cationic polyamines comprise pendant monosaccharide groups, which can... National University Of Singapore

Generation of brown adipose tissue (bat) from mesenchymal cells

Methods of generating functional human brown adipocytes, comprising exposing human stem cells, progenitor cells, or white adipocytes to culture with an differentiation cocktail that comprises one or more browning agents (e.g., one or more macromolecular crowders), and optionally one or more adipogenic agents, are described, as are populations of human... National University Of Singapore

Techniques to improve switching probability and switching speed in sot devices

In one embodiment, a desirable (e.g., substantially 100%) SOT switching probability is achieved in a SOT device by applying in-plane input current as one or more pulses having a tuned pulse width. In the case of a single pulse, pulse width may be selected as a single tuned pulse width... National University Of Singapore

Method to transfer two dimensional film grown on metal-coated wafer to the wafer itself in a face-to-face manner

A method of in-situ transfer during fabrication of a component comprising a 2-dimensional crystalline thin film on a substrate is disclosed. In one embodiment, the method includes forming a layered structure comprising a polymer, a 2-dimensional crystalline thin film, a metal catalyst, and a substrate. The metal catalyst, being a... National University Of Singapore

Highly efficent on-chip direct electronic-plasmonic transducers

In one embodiment, an on-chip electronic-plasmonic transducer is provided that is capable of both direct plasmon generation and detection at high efficiencies. The electronic-plasmonic transducer includes a metal-insulator-metal junction formed from a first wire constructed of a first metal, a tunneling barrier material in contact with the first wire, and... National University Of Singapore

Multi-channel neural signal amplifier system providing high cmrr across an extended frequency range

A high CMRR neural signal amplifier is configured for supply rail common mode feedback (SR-CMFB) whereby a set of CMFB signals is provided to supply rails of front end LNAs. High CMRR is maintained through buffering outputs of front end signal LNAs and a reference LNA coupled to signal and... National University Of Singapore

Methods and systems for automated text correction

The present embodiments demonstrate systems and methods for automated text correction. In certain embodiments, the methods and systems may be implemented through analysis according to a single text correction model. In a particular embodiment, the single text correction model may be generated through analysis of both a corpus of learner... National University Of Singapore

Method and assisting movement rehabilitation

A method and apparatus implementing a tele-rehabilitation system with remote supervision via wireless telecommunication means is disclosed. The method for assisting a user performing musculoskeletal movement in rehabilitation exercise comprises of motion-sensing a first part of user's body to be exercised (e.g. upper or lower limb), and motion-sensing a second... National University Of Singapore

Microrna biomarker for the diagnosis of gastric cancer

Disclosed are methods of determining the likelihood of a subject having or developing a gastric cancer. The methods comprise measuring the expression level of at least one miRNA having at least 90% sequence identity with an miRNA as described herein in a non-cellular biofluid sample obtained from the subject, wherein... National University Of Singapore

Resistive switching co-sputtered pt-(nio-al2o3)-pt devices

In one embodiment, a capacitor-like structure is constructed that includes an RF co-sputtered TMO layer. The capacitor-like structure includes a first electrode (e.g., a bottom electrode) constructed of a first metal (e.g., Pt), a RF co-sputtered TMO layer on the first electrode including a first oxide and a second oxide... National University Of Singapore

A battery system

The present invention relates to batteries and more particularly to battery systems. More particularly, the present invention relates to metal-air based battery systems. In an aspect of the present invention, there is provided a battery system, the system comprising (a) a cell comprising a metal anode and a cathode current... National University Of Singapore

Aptamers for binding flavivirus proteins

The present invention relates to nucleic acids. In particular, it relates to aptamers capable of binding to a flavivirus structural protein or a flavivirus non-structural protein, useful as therapeutics for preventing, treating and/or diagnosing a flavivirus infection in a patient.... National University Of Singapore

Method of improving solvent tolerance in microbes

The invention relates generally to a method of improving solvent tolerance in microbes, and in particular, to a method of improving bio-butanol titre in a fermentation process due to improved solvent tolerance in microbes. The method of improving butanol titre in a fermentation process involves the addition of a membrane... National University Of Singapore

Methods and compositions for modulating th-gm cell function

Disclosed herein is a T-helper cell (“TH-GM” cell) that is regulated by IL-7/STAT5 and which secrete GM-CSF/IL-3. Also disclosed are methods and compositions for modulating TH-GM function for the treatment of, e.g., inflammatory disorders. Diagnostic and prognostic methods for specifically identifying TH-GM-mediated inflammatory disorders (e.g., rheumatoid arthritis), as distinct from... National University Of Singapore

Multilayer heterostructures for application in oleds and photovoltaic devices

This invention relates to a supported polymer heterostructure and methods of manufacture. The heterostructure is suitable for use in a range of applications which require semiconductor devices, including photovoltaic devices and light-emitting diodes.... National University Of Singapore

Thermogelling graft copolymer and preparation thereof

A thermogelling graft copolymer is provided. The copolymer is obtainable by (a) polymerizing, in a first step, an activated lignin-based polymer with N-isopropylacrylamide (NIPAAm) to form a lignin/poly(N-isopropylacrylamide) (PNIPAAm) graft copolymer, and (b) polymerizing, in a second step, the lignin/poly(N-isopropylacrylamide) (PNIPAAm) graft copolymer with a monomer mixture comprising (i) poly(ethylene... National University Of Singapore

Prevention of pertussis using adenylate cyclase deficient bordetella strains

A CyaA-deficient B. pertussis mutant was constructed and used in a vaccine. The pertussis-specific antibody profile and Th17 response induced by vaccination with the mutant was surprisingly comparable to that induced by B. pertussis strains not deficient in CyaA.... National University Of Singapore

07/20/17 / #20170203340

Rapid cleaning ultrapure water piping system

A cleaning method including an alkaline cleaning step followed by an acid cleaning step is used, for example, to treat a newly constructed ultrapure water distribution piping system (using PVDF piping system). The inherent inorganic and organic contaminants in the piping material as well as contaminants deposited (if any) during... National University Of Singapore

07/13/17 / #20170200486

Techniques to modulate spin orbit spin transfer torques for magnetization manipulation

In one embodiment, a SO-STT device has a non-symmetric device geometry. The device may be fabricated to have a non-symmetric magnetic pattern by tilting a shaped magnetic pattern (e.g., an ellipse, diamond, rectangle, etc. shaped magnetic pattern) such that the pattern's main (long and short) axes are tilted with respected... National University Of Singapore

07/13/17 / #20170200851

Device incorporating an oxide film and fabricating the same

A device and a method of forming a device. The method comprises forming an oxide material film; forming two metal electrodes on the oxide material film, the two metal electrodes laterally spaced from each other such that an electric path between the two electrodes comprises at least a portion of... National University Of Singapore

07/06/17 / #20170191765

Device and a two phase heat transfer

The invention provides a two phase heat transfer device comprising an inlet for receiving a heat transfer fluid, and; an array of heat transfer fins in spaced relation; primary spaces between said heat transfer fins defining primary channels parallel to a path from the inlet to outlet, and; oblique spaces... National University Of Singapore

06/29/17 / #20170182221

Methods of producing tissue-mimetic constructs and uses thereof

The present invention relates, in various embodiments, to methods of producing a tissue-mimetic construct having a basement membrane, methods of producing an acellular scaffold containing an extracellular matrix (ECM), methods of producing a scaffold comprising a hydrogel that is enriched in ECM components, methods of treating a condition in a... National University Of Singapore

06/29/17 / #20170186457

Graphene as a protective overcoat for magnetic media without the use of a nucleation layer

A graphene layer, used as an anti-corrosive protection medium for magnetic media, overcomes the existing problem of reducing the carbon overcoat layer thickness for magnetic media. Unlike the amorphous carbon that is currently used as an anti-corrosion layer, the impenetrability of graphene to all known gaseous substances enables full corrosion... National University Of Singapore

06/22/17 / #20170173083

Compositions and methods for ex vivo expansion of human hematopoietic stem/progenitor cells

Described herein are methods and compositions which lead to the efficient ex vivo expansion of hematopoietic cells, such as hematopoietic stem cells (HSCs) and hematopoietic stem and progenitor cells HSPCs. Using combinations of small molecule drugs and cytokines/growth factors/grown factors targeting epigenetic status in cells, significant improvements in the expansion... National University Of Singapore

06/22/17 / #20170174732

Nanobody-flourescent protein fusion

We describe the rational structure-based design of monomeric and dimeric forms of a nanobody-enhanced GFP (termed vsfGFP) that demonstrates ˜1.3-fold higher brightness than sfGFP in a monomeric form and ˜2.5-fold higher brightness in a dimeric form. These new vsfGFP variants demonstrate high stability and brightness in both bacterial and eukaryotic... National University Of Singapore

06/22/17 / #20170174759

Treatment of fibrosis

Aspects of the disclosure relate to the treatment, prevention or alleviation of conditions such as fibrosis in a subject. In some embodiments, the treatment, prevention or alleviation of fibrosis in a subject through the administration of an agent capable of inhibiting the action of Interleukin 11 (IL-11) is disclosed.... National University Of Singapore

06/22/17 / #20170174812

Crosslinked polymers prepared from functional monomers having imidazolium, pyridinium, aryl-substituted urea or aryl-substituted thiourea groups and uses thereof

The invention relates to a polymer obtainable by radical co-polymerisation of a first monomer of general formula (I) or (II) or a mixture thereof: wherein A, A′, B, B′ X, Y, Y′ and n are as defined herein; with a second, cross-linking monomer and optionally with one or more further... National University Of Singapore

06/22/17 / #20170177563

Methods and systems for automated text correction

The present embodiments demonstrate systems and methods for automated text correction. In certain embodiments, the methods and systems may be implemented through analysis according to a single text correction model. In a particular embodiment, the single text correction model may be generated through analysis of both a corpus of learner... National University Of Singapore

06/22/17 / #20170179561

Reconfigurable waveguide for spin wave transmission

A waveguide for spin wave (SW) transmission, a method of fabricating a waveguide for SW transmission, and a method of transmitting an SW. The waveguide comprises a plurality of nanomagnetic material elements, each nanomagnetic material element having a respective predetermined geometric shape such that each nanomagnetic material element exhibits a... National University Of Singapore

06/15/17 / #20170164869

Systems and methods for tracking and displaying endoscope shape and distal end orientation

Systems and methods for tracking shape and orientation of an endoscope employ motion tracking sensors to track locations on the endoscope for use in determining real time shape and distal end orientation for display during navigation of the endoscope. An example system includes sensor units distributed along the endoscope and... National University Of Singapore

06/15/17 / #20170166867

2,4,5-tri-substituted azole-based casein kinase 1 inhibitors as inducers for cardiomyogenesis

This invention relates to a method for inducing or enhancing the differentiation of pluripotent stem cells into cardiomyocyte via casein kinase 1 inhibition said method comprising culturing the stem cells in the presence of a medium comprising a casein kinase 1 inhibitor of the formula (I) or (II) or a... National University Of Singapore

06/15/17 / #20170168041

Polymers and oligomers with aggregation-induced emission characteristics for imaging and image-guided therapy

A fluorophore or conjugated polymer with aggregation-induced emission characteristics useful for drug tracking and delivery, identification and labeling of biological subjects, such as cells or parts of a cell, as well as for imaging, and image-guided photodynamic therapy are described herein.... National University Of Singapore

06/15/17 / #20170168073

Chalcone-urea derivatives as insulin sensors

The invention relates to compounds of formula (I) or derivatives, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts, pharmaceutical compositions, metabolites or prodrugs thereof, in which the substituents are as defined in the specification. These compounds may be useful as insulin sensors; in insulin secretion studies and as probes... National University Of Singapore

06/08/17 / #20170158742

Biotinylated protein

Disclosed are methods of screening a library of molecules to identify or select one or more molecules which selectively bind to a fused protein, or fragment thereof. The fused protein comprises a moiety and a protein selected from a group consisting of flavivirus structural and non-structural (NS) proteins. The method... National University Of Singapore

05/25/17 / #20170144107

Graphene-based membrane and preparation thereof

A method of preparing a graphene-based membrane is provided. The method may include providing a stacked arrangement of layers of a graphene-based material, wherein the layers of the graphene-based material define one or more nanochannels between neighboring layers, and varying an electrical charge on a surface of the layers of... National University Of Singapore

05/18/17 / #20170138860

Raman spectroscopy system, apparatus, and analyzing, characterizing, and/or diagnosing a type or nature of a sample or a tissue such as an abnormal growth

Characterizing, identifying, or diagnosing the type and/or nature of a sample or a tissue such as an abnormal growth using a Raman spectrum includes analyzing distinct spectral subintervals within the Raman spectrum in two distinct wavelength ranges, such as FP and HW wavelength ranges, to identify a match with one... National University Of Singapore

05/18/17 / #20170139495

Human-machine interface with graphene-pyroelectric materials

A version of the invention comprises a device for controlling or interfacing with a computer or other form of communicable machine based on the pyroelectric effect, and includes at least one optically- and infrared- (IR-) transparent graphene electrode.... National University Of Singapore

05/04/17 / #20170119614

Actuator device, limb rehabilitation

An actuator device, a method and a system for limb rehabilitation, and a pneumatic actuator element. The actuator device for limb rehabilitation comprises one or more pneumatic actuator elements; and means for coupling the pneumatic actuator elements to the limb at or near one or more joints of the limb;... National University Of Singapore

05/04/17 / #20170121271

Multiphase reactor system

A one-to-many parallelized millireactor system capable of high throughput production in millireactors. Also disclosed is a method for carrying out multi-phase reactions.... National University Of Singapore

05/04/17 / #20170121720

Combinatorial metabolic engineering of saccharomyces cerevisiae for terminal alkene production

Modified Saccharomyces cerevisiae yeast that produce terminal alkenes are described. The modification of the Saccharomyces cerevisiae yeast includes insertion of at least one heterologous fatty acid decarboxylase gene, deletion of FAA1 and FAA4, overexpression of HEM3, and triple-deletion of CTT1, CTA1 and CCP1. Methods of producing terminal alkenes by culturing... National University Of Singapore

04/20/17 / #20170106074

Influenza vaccine, composition, and methods of use

The invention relates to compositions and vaccines that include a mutated Bordetella strain for treating or preventing an influenza infection in a mammal. In addition, the invention further provides methods for protecting a mammal against infection by influenza and/or eliciting an immune response against an influenza virus in a mammal... National University Of Singapore

04/20/17 / #20170107491

Chimeric receptor with nkg2d specificity for use in cell therapy against cancer and infectious disease

The invention provides a chimeric receptor comprising NKG2D, DAP10 and CD3 zeta. Also disclosed is a composition comprising this chimeric receptor and methods for making and using it to enhance the cytotoxicity and antitumor capacity of NK cells. The invention also encompansses methods for use of NKG2D-DAP10-CD3 zeta polypeptides, vectors... National University Of Singapore

04/13/17 / #20170101358

Triphasic flow millireactors

Disclosed is a reactor system that contains multiple millireactors, each including a millitube, a first feed line, a second feed line, and a third feed line. Each of the first and second feed lines has a hydraulic damper disposed therein. Also disclosed is a process for conducting in a millitube... National University Of Singapore

04/13/17 / #20170101459

Cleavage and exchange of major histocompatibility complex ligands employing azobenzene-containing peptides

In one aspect, the disclosure relates to major histocompatibility complex (MHC) molecules comprising a ligand in the peptide binding groove of the MHC molecule, whereby the ligand comprises an azobenzene (Abc), and at least two amino acid residues separated by the azo-group of the Abc, and wherein the amino acid... National University Of Singapore

04/13/17 / #20170102473

Wing for wide tow of geophysical survey sources

Techniques are disclosed relating to wide towing of marine survey signal sources. In one embodiment, an apparatus includes a signal source and a wing coupled to the signal source. In this embodiment, the wing is configured to impart a force to the signal source when towed through a body of... National University Of Singapore

04/06/17 / #20170098760

Transition metal dichalcogenide-based spintronics devices

Transition metal dichalcogenide (TMD)-based spintronics devices, each including a TMD thin film layer, a first gate electrode, a first insulating layer sandwiched between the TMD thin film layer and the first gate electrode, a second gate electrode, and a second insulating layer sandwiched between the TMD thin film layer and... National University Of Singapore

03/23/17 / #20170081723

Fusion genes in cancer

The present invention relates to a method for determining or making of a prognosis if a patient has cancer or is at an increased risk of having cancer, the method comprising testing for the presence of one or more cancer-associated fusion genes, or proteins derived thereof, in a sample obtained... National University Of Singapore

Patent Packs
03/16/17 / #20170073638

Modified natural killer cells and uses thereof

The present invention provides, in certain aspects, a natural killer (NK) cell that expresses all or a functional portion of interleukin-15 (IL-15), and methods for producing such cells. The invention further provides methods of using a natural killer (NK) cell that expresses all or a functional portion of interleukin-15 (IL-15)... National University Of Singapore

03/09/17 / #20170067084

Production of chiral 1,2-amino alcohols and alpha-amino acids from alkenes by cascade biocatalysis

Disclosed herein are methods of forming chiral 1,2-aminoalcohols and α-aminoacids from alkene starting materials by way of an enzymatic cascade reaction sequence that may be accomplished in a single reaction vessel without the need to isolate any intermediates. Also disclosed herein are recombinant nucleic acids, vectors and host cells for... National University Of Singapore

03/09/17 / #20170067919

Compositions and methods utilizing lysophosphatidylcholine scaffolds

The invention relates to compositions and methods for utilizing lysophosphatidylcholine scaffolds. The compositions and methods can be used for LPC-mediated delivery of fatty acids and other molecules; to screen and identify fatty acid formulations for parenteral nutrition; and for live animal organ imaging, among other uses. The invention also provides... National University Of Singapore

02/23/17 / #20170049997

Arterial sheath which allows distal perfusion within a cannulated vessel

Defining proximal as toward the heart and distal as away from the heart, a sheath includes a proximal opening and multiple fenestrations maintainable in position slightly beyond a site or point of sheath entry into a vessel by way of an anchoring assembly having a set of radially displaceable anchoring... National University Of Singapore

02/16/17 / #20170042439

System, brainwave-based technologies

System, device and methods for brainwave-based technologies. The system for measuring and processing brainwave data of a user comprises one or more electrodes for measuring the brainwave data of the user, and a processing unit coupled to the electrodes and configured to process the brainwave data for determining a current... National University Of Singapore

02/16/17 / #20170044479

Dispase-based junctional protein tensor dish

Cell-culture devices and methods for determining the integrity of cell-cell adhesion are described. A cell culture device includes a channel-defining body that defines a plurality of channels in a cell-culture dish and a removable mask located above the channel-defining body. Channels of the cell-culture dish can be seeded and maintained... National University Of Singapore

02/16/17 / #20170045397

Device for analysing a specimen and corresponding method

A device for analysing a specimen is disclosed. The device comprises a first polarizer for polarizing a first beam of electromagnetic radiation; an optical device for directing the polarized beam of electromagnetic radiation at the specimen to enable interaction between the polarized beam of electromagnetic radiation and the specimen to... National University Of Singapore

02/16/17 / #20170045520

Method for predicting response to therapy for cancer

The present invention provides a method of predicting response of a cancer patient to a therapy. The method comprises the step of determining a presence or absence of at least one mutation of ITCH (SEQ ID NO: 1) in a first sample isolated from a cancer patient, wherein the presence... National University Of Singapore

02/09/17 / #20170038371

Combinatoric encoding methods for microarrays

A method for determining a presence or absence of one or more target analytes in a sample includes contacting the sample with an array of particles comprising at least first and second particle subsets disposed therein with a known particle number ratio with respect to each other. The first particle... National University Of Singapore

02/02/17 / #20170029489

Human monoclonal antibody with specificity for dengue virus serotype 1 e protein and uses thereof

Compositions and methods for the treatment or prevention of Dengue virus infection in a vertebrate subject are provided. In particular, human neutralizing monoclonal antibodies to Dengue virus isolated from EBV immortalized B cells derived from patients who have recovered from Dengue infection are disclosed. Methods are provided for administering such... National University Of Singapore

02/02/17 / #20170032815

Method of protecting a magnetic layer of a magnetic recording medium

A method of protecting a magnetic layer of a magnetic recording medium is provided to reduce the thickness of the magnetic spacing while improving corrosion resistance and tribological performance of the magnetic recording medium.... National University Of Singapore

02/02/17 / #20170033800

Symmetrical capacitor arrays succesive approximation register (sar) analog-to-digital converter (adc)

Analog-to-digital converter (ADC) circuitry includes a first binary-weighted capacitor array having a total capacitance of 2n-2C. The value of n represents number of bits of a digital signal that represents an analog signal. The ADC circuitry also includes a second binary-weighted capacitor array having a total capacitance of 2n-2C. In... National University Of Singapore

01/26/17 / #20170020730

Ocular drainage device and manufacturing thereof

Aspects of the present disclosure are directed to an ocular drainage device that includes a stability system. The stability system includes a plate, and can further include a material comprising collagen covering at least a portion of a top surface of the plate, and/or a viscoelastic substance covering at least... National University Of Singapore

01/26/17 / #20170022503

Methods of modulating wars2

The present invention provides methods and agents for modulating WARS2 expression, WARS2 activity, or a combination thereof, thereby modulating angiogenesis. Also provided herein are methods for identifying individuals who could benefit from agents that modulate WARS2 expression, WARS2 activity, or a combination thereof.... National University Of Singapore

01/19/17 / #20170014768

Highly permeable double-skinned forward osmosis membrane for anti-fouling in the emulsified oil-water separation process

A double-skinned membrane that includes a polymeric support having a thickness of 20 to 500 nm, a first surface and a second surface opposed to each other; a polymeric thin film layer having a thickness of 1 to 1000 nm and covering the first surface; and a sulfonated pentablock copolymer... National University Of Singapore

Patent Packs
01/19/17 / #20170014776

Anti-fouling membranes

A membrane assembly is provided. The membrane assembly comprises a membrane having a first surface and an opposing second surface, and a layer of anti-fouling polymer selected from the group consisting of an optionally functionalized hyperbranched polyglycerol, a hyperbranched polyimine, a zwitterionic copolymer obtainable by polymerizing 2-methacryloyloxyethyl lipoate with at... National University Of Singapore

01/19/17 / #20170016770

Optical interference device

An optical interference device 100 is disclosed herein. In a described embodiment, the optical interference device 100 comprises a phase shifter array 108 for receiving a collimated beam of light. The phase shifter array 108 includes an array of cells 128 for producing optical light channels from respective rays of... National University Of Singapore

01/12/17 / #20170007800

Arterial cannula which allows proximal and distal perfusion within a cannulated vessel

A cannula includes a first segment configured to reside entirely within a vessel. The first segment includes a proximal exit opening disposed nearer to the heart, and multiple fenestrations disposed distally away from the proximal exit opening near a cannulation site. The fenestrations in combination with the proximal exit opening... National University Of Singapore

01/12/17 / #20170009208

Biophysically sorted osteoprogenitors from culture expanded bone marrow derived mesenchymal stromal cells (mscs)

The invention provides, inter alia, populations of large mesenchymal stem cells (MSC)(as well as conditioned medium from these cells) with enhanced regenerative potential, as well as methods of culturing and using these populations, such as therapeutic methods of mediating tissue repair or enhancing homing and engraftment of hematopoietic stem cells.... National University Of Singapore

01/05/17 / #20170000850

Differentiation therapy with cd137 ligand agonists

There is disclosed a method of treating cancer comprising administering an agonist of CD137 ligand (CD137L) to a subject in need thereof.... National University Of Singapore

01/05/17 / #20170000887

Uniform core-shell tio2 coated upconversion nanoparticles and use thereof

An upconversion nanoparticle (UCN) coated with a layer of semiconductor material is disclosed. The UCN core acts as a nanotransducer to convert near infrared (NIR) to visible and/or ultraviolet (UV) light while the semiconductor shell serves as a photocatalyst. Upon excitation by NIR light, the UCN upconverts NIR light to... National University Of Singapore

01/05/17 / #20170000908

A micellar particle

There is provided a micellar particle having at least a core-shell configuration, wherein a fluorescent molecule is encapsulated within said core and wherein said shell is formed from an inorganic compound.... National University Of Singapore

01/05/17 / #20170002366

Microbial engineering for the production of chemical and pharmaceutical products from the isoprenoid pathway

The invention relates to recombinant expression of a taxadiene synthase enzyme and a geranylgeranyl diphosphate synthase (GGPPS) enzyme in cells and the production of terpenoids.... National University Of Singapore

01/05/17 / #20170002382

Microbial engineering for the production of chemical and pharmaceutical products from the isoprenoid pathway

The invention relates to the production of one or more terpenoids through microbial engineering, and relates to the manufacture of products comprising terpenoids.... National University Of Singapore

01/05/17 / #20170005663

Nanomagnetic network structures and a reconfigurable operation based on magnetization dynamics

A nanomagnetic structure and a method of fabricating a nanomagnetic structure. The nanomagnetic comprises two or more nanomagnetic material elements, each nanomagnetic material element having a respective predetermined geometric shape such that the nanomagnetic structure exhibits different stable ground states initializable by magnetic fields applied across the nanomagnetic structure in... National University Of Singapore








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