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New England Biolabs Inc
New England Biolabs Inc_20131212

New England Biolabs Inc patents


Recent patent applications related to New England Biolabs Inc. New England Biolabs Inc is listed as an Agent/Assignee. Note: New England Biolabs Inc may have other listings under different names/spellings. We're not affiliated with New England Biolabs Inc, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "N" | New England Biolabs Inc-related inventors


Methods and compositions for preventing concatemerization during template-switching

Compositions and methods for performing a template-switching reaction are provided that may include reducing or eliminating concatemerization of the template-switching oligonucleotide (TSO). In some embodiments, the composition may comprise: a reverse transcriptase; a TSO that includes a recognition sequence for a site-specific double strand nucleic acid cleaving enzyme, wherein the... New England Biolabs Inc

Enrichment and sequencing of rna species

Provided herein is a method for making an cDNA library, comprising adding an affinity tag-labeled GMP to the 5′ end of targeted RNA species in a sample by optionally decapping followed by incubating the sample with an affinity tag-labeled GTP and a capping enzyme, enriching for RNA comprising the affinity... New England Biolabs Inc

Compositions and methods relating to synthetic rna polynucleotides created from synthetic dna oligonucleotides

Compositions and methods are provided for forming a single RNA polynucleotide from a plurality of DNA oligonucleotides in a single reaction chamber using combined reagents in a single step reaction. DNA polymerase, RNA polymerase and single stranded (ss) DNA oligonucleotides are combined where each DNA oligonucleotide has one or more... New England Biolabs Inc

Methods for enriching for a population of rna molecules

A method of enriching for a population of RNA molecules in a mixture of RNAs is provided. In some embodiments, the method may comprise (a) adding an affinity tag to the 5′ end of 5′-diphosphorylated or 5′-triphosphorylated RNA molecules in a sample by incubating the sample with an affinity tag-labeled... New England Biolabs Inc

Thermostable variants of t7 rna polymerase

A bacteriophage RNA polymerase variant is provided. In some embodiments, the variant may have increased thermostability relative to the corresponding wild type bacteriophage RNA polymerase and/or wild type T7 RNA polymerase. Compositions, kits and methods that employ the variant are also provided.... New England Biolabs Inc

Compositions and methods for extending storage time of competent cells at -20°c

Compositions and methods are provided for storing prokaryotic cells including competent prokaryotic cells at −20° C. in a buffer so that the cells are suitable for transformation at 0° C. with a foreign molecule.... New England Biolabs Inc

Compositions and methods for analyzing modified nucleotides

A method for identifying any of the presence, location and phasing of modified cytosines (C) in long stretches of nucleic acids is provided. In some embodiments, the method may comprise (a) reacting a first portion of a nucleic acid sample containing at least one C and/or at least one modified... New England Biolabs Inc

Fusion polymerase and using the same

This disclosure provides, among other things, a composition comprising: comprising a fusion protein comprising: (a) a DNA polymerase; and (b) a heterologous sequence-specific DNA binding domain. A method for copying a DNA template, as well as a kit for performing the same, are also described.... New England Biolabs Inc

Fusion polymerase and using the same

This disclosure provides, among other things, a composition comprising: comprising a fusion protein comprising: (a) a DNA polymerase; and (b) a heterologous sequence-specific DNA binding domain. A method for copying a DNA template, as well as a kit for performing the same, are also described.... New England Biolabs Inc

Deglycosylation reagents and methods

Compositions and methods are provided for efficiently preparing a completely deglycosylated antibody where efficiency is measured in relative amounts of reagents in soluble or lyophilized form, and time and temperature of the reaction. Compositions and methods are also provided for separating substantially all N-linked glycans from a glycosylated antibody and... New England Biolabs Inc

Universal n-glycan binding reagent

Methods of capturing N-glycan linked glycomolecules including N-glycans, N-glycopeptides and N-glycoproteins are described. The methods provide substantially unbiased capture of charged and uncharged N-glycans and/or N-glycan linked glycomolecules. Binding reagents for substantially unbiased binding of N-glycans and/or N-glycan linked glycomolecules are also described.... New England Biolabs Inc








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