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Northwestern University patents

Recent patent applications related to Northwestern University. Northwestern University is listed as an Agent/Assignee. Note: Northwestern University may have other listings under different names/spellings. We're not affiliated with Northwestern University, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "N" | Northwestern University-related inventors

 new patent  Acellular scaffolds for maturation of ipsc-hepatocytes

Provided herein are compositions and systems comprising induced pluripotent stem cell (iPSC)-derived hepatocytes and systems and methods for acellular maturation thereof. In particular, iPSC-derived hepatocytes are matured on decellularized extracellular matrix (ECM) to yield cells with enhanced hepatocytic biomarkers and functionality.... Northwestern University

 new patent  Method for rapid in vitro synthesis of bioconjugate vaccines via recombinant production of n-glycosylated proteins in prokaryotic cell lysates

Disclosed are methods, systems, components, and compositions for cell-free synthesis of glycosylated proteins. The glycosylated proteins may be utilized in vaccines, including anti-bacterial vaccines. The glycosylated proteins may include a bacterial polysaccharide conjugated to a carrier, which may be utilized to generate an immune response in an immunized host against... Northwestern University

 new patent  Highly productive one-pot system for the incorporation of non-standard amino acids into cell-free synthesized proteins

Disclosed are methods, systems, components, and compositions related to genomically recoded and engineered organisms. The disclosed genomically recoded and engineered organisms may be used to prepare extracts for use in platforms and methods for preparing sequence defined biopolymers in vitro. In particular, the methods, systems, components, and compositions relate to... Northwestern University

 new patent  Compositions and methods for detecting nucleic acids in sputum

This disclosure relates generally to methods and kits useful for preparing samples, extracting nucleic acids from samples (e.g., biological samples), and/or detecting nucleic acids (e.g., pathogen nucleic acids) in samples (e.g., samples obtained from a subject). In particular, compositions, kits, and methods are provided comprising detergents and proteinases to treat... Northwestern University

 new patent  Biological tissue analysis by inverse spectroscopic optical coherence tomography

A method and system to measure and image the full optical scattering properties by inverse spectroscopic optical coherence tomography (ISOCT) is disclosed. Tissue is modeled as a medium with continuous refractive index (RI) fluctuation and such a fluctuation is described by the RI correlation functions. By measuring optical quantities of... Northwestern University

 new patent  Three dimensional extrusion printed electrochemical devices

Solid oxide electrochemical devices, methods for making the electrochemical devices, and methods of using the electrochemical devices are provided. The electrochemical devices comprise a plurality of stacked functional layers that are formed by a combination of three-dimensional (3D) extrusion printing and two-dimensional (2D) casting techniques.... Northwestern University

Systems, methods, and esophageal panometry

Systems, methods, and apparatus for esophageal panometry are provided. An example method includes capturing measurement data including an area and a pressure of an esophageal body via a measurement device positioned with respect to the esophageal body; generating representations of the exported measurement data; analyzing the measurement data to determine... Northwestern University

Therapeutic targeting of set1b/compass pathway for treating cancers

Disclosed are methods for treating Set1/COMPASS-associated cancers characterized by expression of Set1B/COMPASS. The methods typically include administering a therapeutic amount of an inhibitor of the Set1B/COMPASS pathway and/or an agonist for a target that is negatively regulated by the Set1B/COMPASS pathway.... Northwestern University

Enhanced conductivity, adhesion and environmental stability of printed graphene inks with nitrocellulose

Graphene ink compositions comprising nitrocellulose and related methods of use comprising either thermal or photonic annealing.... Northwestern University

Haptic device with indirect haptic feedback

A method of imitating a texture on a touch surface, the method including the steps of sensing a position of a user's finger on the touch surface, modulating a coefficient of friction of the touch surface in response to the sensed position of a user's appendage relative to the touch... Northwestern University

Optical discs as low-cost, quasi-random nanoimprinting templates for photon management

Photonic devices are provided comprising a photoactive layer and at least one additional layer, wherein a surface of the photoactive layer or a surface of the at least one additional layer has imprinted thereon a quasi-random pattern of nanostructures corresponding to a quasi-random pattern of nanostructures defined in a recording... Northwestern University

Compositions, patient specific ophthalmic device

Systems, methods, and devices to fabricate one or more device components are disclosed. An example method includes fabricating one or more subject specific device components generated from receiving one or more images of one or more features of the first eye of the subject; designing a three dimensional virtual geometric... Northwestern University

Tonometry based blood pressure measurements using a two-dimensional force sensor array

Representative methods, apparatus and systems are disclosed for blood pressure and other vital sign monitoring using arterial applanation tonometry, including ambulatory blood pressure and other vital sign monitoring. A representative system comprises a wearable apparatus. The various embodiments measure blood pressure and other vital sign monitoring using a plurality of... Northwestern University

High density lipoprotein functionalized magnetic nanostructures

Provided herein are compositions and methods for diagnosis and treatment of early-stage atherosclerotic plaques and reduction of plaques in arteries. In particular, provided herein are high-density-lipoprotein-functionalized magnetic nanostructures (HDL-MNS) capable of (i) precise anatomic detection of atherosclerotic lesions, (ii) removal of excess cholesterol from macrophage cells in atherosclerotic plaque, and/or... Northwestern University

Photoluminescent panthenol citrate biomaterials

Provided herein are compositions comprising panthenol-citrate containing materials. In particular, panthenol citrate compounds, oligomers, and polymers, and methods of use and synthesis thereof, are provided herein. Panthenol-citrate containing materials are a class of nontoxic, photoluminescent-chromophore-containing compounds, oligomers, and polymers with high absorption in the UVA and UVB range that can... Northwestern University

Map kinase modulators and uses thereof

The invention provides for novel MAP kinase inhibitors and compositions comprising the same. In some embodiments, the MAP kinase inhibitors are p38α MAP kinase inhibitors. The invention further provides for methods for treatment of diseases comprising administration of MAP kinase inhibitors or compositions comprising MAP kinase inhibitors. In some embodiments,... Northwestern University

Artificial ovary

Artificial ovaries comprising porous three-dimensional scaffolds are provided. Also provided are ink compositions and methods for printing the scaffolds. The artificial ovaries have spatial arrangements and cellular compositions that allow them to mimic native ovarian tissue. As such, they can be cultured or transplanted to support female endocrine function and/or... Northwestern University

Thromboresistant-anticoagulant extracellular matrix

Provided herein are bioactivated polymer/extracellular matrix (ECM) composites and methods of preparation and use thereof. In particular, heparinized cysteine-polymer/ECM composites, and methods of preparation and use thereof, are provided. In some embodiments, provided herein are compositions comprising a composite of: (a) extracellular matrix (ECM), and (b) a polyester covalently linked... Northwestern University

Zirconium- and hafnium-based metal-organic frameworks as epoxide ring-opening catalysts

Metal-organic frameworks (MOFs) and method of using the MOFs to catalyze reactions involving epoxide ring-opening mechanisms are provided. The structure of the MOFs can be represented by the formula: M6(μ3-ligand)8(OHx)8(TBAPy)2, where M is Zr or Hf, the ligands are selected from hydroxo-, oxo- and aquo-ligands, and x is independently selected... Northwestern University

Self-similar and fractal design for stretchable electronics

The present invention provides electronic circuits, devices and device components including one or more stretchable components, such as stretchable electrical interconnects, electrodes and/or semiconductor components. Stretchability of some of the present systems is achieved via a materials level integration of stretchable metallic or semiconducting structures with soft, elastomeric materials in... Northwestern University

Intranasal occlusion device and methods of using the same

An intranasal occlusion device having an inflatable balloon within a sponge that is used to prevent drainage of fluid, such as blood and other fluids into the airway during sinus and nasal minor procedures or surgeries, and methods of using the device to occlude an intranasal cavity of a patient.... Northwestern University

High density lipoprotein nanoparticles for inflammation

The invention in aspects relates to methods of treating sepsis using HDL-NP. The methods include the use of nanoparticles having a core and a lipid based shell with optimal lipids therein.... Northwestern University

Arsenoplatin anti-cancer agents

M is Pt, Pd or Ni; Q is As, Sb or Bi; Z1 is N; Z2 is O or S; L1 and L2 are independently C(O), C—R1 or C—R2; X is a Lewis base; Y1 and Y2 are independently selected from —OR3, —OR4, —SR3 and —SR4, wherein R1 and R2... Northwestern University

Electrode material comprising graphene-composite materials in a graphite network

A durable electrode material suitable for use in Li ion batteries is provided. The material is comprised of a continuous network of graphite regions integrated with, and in good electrical contact with a composite comprising graphene sheets and an electrically active material, such as silicon, wherein the electrically active material... Northwestern University

Treatment of amyotrophic lateral sclerosis

The present invention relates to the identification of compounds and pharmaceutical compositions thereof for treating subjects with amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. The invention also provides methods of preparing the provided compounds.... Northwestern University

Methods for activating natural energy metabolism for improving yeast cell-free protein synthesis

Disclosed are compositions, methods, and kits for enhanced synthesis of a biological macromolecule in vitro using cell-free protein synthesis. The compositions, methods, and kits include or utilize: a cell-free extract; a phosphate-free energy source; and a phosphate source, and typically do not include an exogenous nucleoside triphosphate or an exogenous... Northwestern University

System and associative power and clock management with instruction governed operation for power efficient computing

A system includes an ARM core processor, a programmable regulator, a compiler, and a control unit, where the compiler uses a performance association outcome to generate a 2-bit regulator control values encoded into each individual instruction. The system can provide associative low power operation where instructions govern the operation of... Northwestern University

Spatiotemporal background phase correction for phase contrast velocity encoded mri

A computer-implemented method for performing spatiotemporal background phase correction for phase contrast velocity encoded magnetic resonance imaging includes performing a phase contrast magnetic resonance imaging scan of a region of interest within a patient to yield a complex image and calculating a plurality of filter cut-off frequencies based on physiological... Northwestern University

Haptic touch screen and operating the same

A haptic touch screen including a lower layer including a plurality of control electrodes, an upper layer including a plurality of haptic electrodes, a middle layer between the lower layer and upper layer, where the haptic electrodes are not conductively connected to control electronics.... Northwestern University

Methods and systems for identifying non-penetrating brain injuries

The present disclosure provides methods for identifying non-penetrating brain injury in a subject, as well as methods for classifying a subject that received a hit to the body that transmitted an impulsive force to the brain as either having a non-penetrating brain injury or not, by analyzing one or more... Northwestern University

Systems and methods for untargeted metabolomic screening

Provided herein are systems and methods for untargeted screening of metabolite products of biosynthetic gene clusters. In particular, systems and methods are provided for the detection of secondary metabolites and the correlation off such metabolites to the biosynthetic gene clusters responsible for the biosynthesis thereof.... Northwestern University

Maspin-based inhibition of osteoclast activity and promotion of bone formation

Provided herein are compositions and methods for the treatment of bone disorders through the maspin-based inhibition of osteoclastogenesis and osteoclast activity and the promotion of bone formation.... Northwestern University

Analogs of adenosine monophosphate (amp) as inhibitors of ubiquitin-like modifier-activating enzyme atg7

Disclosed are analogs of adenosine monophosphate (AMP) as inhibitors of ubiquitin-like modifier-activing enzyme ATG7. The AMP analogs may be formulated as pharmaceutical compositions for treating diseases or disorders that depend on ATG7 activity and/or autophagy such as cell proliferative diseases and disorders.... Northwestern University

Peptide conjugated particles

The present invention provides compositions comprising peptide-coupled biodegradable poly(lactide-co-glycolide) (PLG) particles. In particular, PLG particles are surface-functionalized to allow for coupling of peptide molecules to the surface of the particles (e.g., for use in eliciting induction of immunological tolerance).... Northwestern University

Short interfering rna templated lipoprotein particles (sirna-tlp)

Nanostructures for the systemic delivery of nucleic acids, such as RNA, are provided herein. The nanostructures include templated lipoprotein nanoparticles (TLPs) composed of a core decorated with proteins, a lipid bilayer and hydrophobic molecules that self-assemble with nucleic acids, such as RNA. The nanostructures are useful for research, therapeutic and... Northwestern University

11/02/17 / #20170313747

Self-assembled nanostructures

The present disclosure is directed to the preparation of nanostructures by the encapsulation of a charged compound with individual self-assembled unit nanostructures.... Northwestern University

10/26/17 / #20170304232

Endoxifen for local transdermal therapy to the breast

Disclosed are methods and topical formulations for treating and/or preventing cell proliferative diseases and disorders including breast cancer and ductal carcinoma is situ (DCIS) using local transdermal therapy (LTT). The disclosed methods typically include administering topically to the breast or breasts of the patient a topical formulation comprising an effective... Northwestern University

10/26/17 / #20170304587

Phase-locked loop to enhance slow wave sleep

Certain examples provide systems and methods to enhance slow wave sleep. An example method includes identifying a sleep stage for slow wave sleep in a subject being monitored. The example method also includes generating, following identification of slow wave sleep and using a processor including a phase locked loop, an... Northwestern University

10/26/17 / #20170305813

Sulfur as a selective oxidant in oxidative hydrocarbon processing over oxide/chalcogenide catalysts

Methods for oxidative coupling of methane using metal oxide catalysts and a sulfur oxidant.... Northwestern University

10/26/17 / #20170305901

Therapeutic targeting of interleukin-1 receptor-associated kinase 4 (irak4) in cancers characterized by rearrangements in the mixed lineage leukemia gene (mll-r)

Disclosed are methods for treating cancers associated with rearrangements in the mixed lineage leukemia gene (MLL-r), including MLL-r leukemia. The methods typically include administering a therapeutic amount of one or more therapeutic agents that inhibit the biological activity of one or more members of the interleukin-1 signaling pathway such inhibitors... Northwestern University

10/26/17 / #20170305998

Modified pigment epithelium-derived factor (pedf) peptides and uses thereof for treating neovascular diseases, inflammatory diseases, cancer, and for cytoprotection

Disclosed are modified pigment epithelium-derived factor (PEDF) peptides, particulate carrier prodrugs thereof, and pharmaceutical compositions comprising the peptides or particulate carrier prodrugs. The peptides, particulate carrier prodrugs, and pharmaceutical compositions may be used to treat diseases and disorders that are amenable to treatment with anti-angiogenic agents, anti-tumorigenic agents, anti-fibrotic agents,... Northwestern University

10/26/17 / #20170306258

Lubricant additives, lubricant compositions, and applications of same

A lubricant composition includes a base lubricant and a plurality of lubricant additive molecules. Each lubricant additive molecule includes a surface active group attractable to a target surface, and a carbon containing component connected to the surface active group, for providing a carbon source to form a carbon film on... Northwestern University

10/26/17 / #20170306320

Methods for in vitro ribosome synthesis and evolution

Disclosed are methods, components, compositions, and kits for preparing and identifying engineered E. coli ribosomes. The E. coli ribosomes may be prepared and identified under a set of defined conditions, such as in the presences of antibiotics, in order to obtain an engineered ribosome that is resistant to the antibiotic.... Northwestern University

10/26/17 / #20170307440

Devices, methods, and systems relating to super resolution imaging

Certain examples disclose systems and methods for imaging a target. An example method includes: a) activating a subset of light-emitting molecules in a wide field area of a target using an excitation light; b) capturing one or more images of the light emitted from the subset of the molecules illuminated... Northwestern University

10/26/17 / #20170308597

Systems and methods for enabling situational awareness for events via data visualization

Aspects of the present disclosure relate to data visualization, and more specifically, to technology that automatically visualizes various analytics and predictions generated for mass participation endurance events, or other events of interest.... Northwestern University

10/26/17 / #20170309747

System and threshold logic with electrostatically formed nanowire transistors

An electrostatically formed nanowire transistor, includes a source, a drain, and multiple gates surrounding a doped silicon region. The gates include a top gate, a bottom gate, and side gates. The gates induce a channel in said doped silicon region. The channel has a width which is decreased by negative... Northwestern University

10/19/17 / #20170297988

Efficient catalytic greenhouse gas-free hydrogen and aldehyde formation from alcohols

Catalytic preparation of hydrogen and aldehyde(s) from alcohols, including bioalcohols, without production of carbon monoxide or carbon dioxide.... Northwestern University

10/19/17 / #20170298021

2-aminopyridine-based selective neuronal nitric oxide synthase inhibitors

Aminopyridine compounds, as can be used in conjunction with methods for modulation of nitric oxide synthase activity.... Northwestern University

10/19/17 / #20170299706

System and multi-user two-way ranging

A node in a wireless network includes a memory, transceiver, and processor operatively coupled to one another. The memory stores a signature of the node. The transceiver is configured to transmit, during an initial frame, the signature to one or more neighboring nodes, and receive, during the initial frame, a... Northwestern University

10/19/17 / #20170299811

X(2) modulators and related devices with barium titanate photonic crystal waveguides

Barium titanate thin film waveguides and related modulator and devices with photonic crystal structures to promote wide bandwidths, low operating voltages and small footprint.... Northwestern University

10/12/17 / #20170290944

Promotion of wound healing

The present invention provides compositions and methods that promote wound healing in a subject with a cutaneous injury. In particular, the present invention provides systemic and/or local administration of one or more compositions that cause ganglioside depletion (e.g., glucosylceramide synthase (GCS) inhibitors) for the treatment of cutaneous wounds.... Northwestern University

10/12/17 / #20170291817

Purification of carbon nanotubes via selective heating

The present invention provides methods for purifying a layer of carbon nanotubes comprising providing a precursor layer of substantially aligned carbon nanotubes supported by a substrate, wherein the precursor layer comprises a mixture of first carbon nanotubes and second carbon nanotubes; selectively heating the first carbon nanotubes; and separating the... Northwestern University

10/12/17 / #20170293009

Magnetic barcode imaging

Provided herein is technology relating to magnetic resonance imaging contrast agents and particularly, but not exclusively, to methods and systems for visualizing one or more magnetic resonance imaging contrast agent.... Northwestern University

10/05/17 / #20170281680

Scaffold delivery of immune suppressors and transplant material for control of transplant rejection

The present invention provides compositions, devices, and methods for the coordinated delivery of transplant material and immune suppressors for control of transplant rejection. In particular embodiments, immune suppression cells (e.g., regulatory T cells) and transplant material (e.g., cells, tissue, etc.) are provided within a delivery scaffold for transplant into a... Northwestern University

10/05/17 / #20170281798

Synthetic scaffolds for metastasis detection

Provided herein are synthetic scaffolds engineered to function as a pre-metastatic niche to detect metastasis. In particular, synthetic scaffolds described herein provide detection of the earliest events in metastasis, thereby enabling treatment of metastasis before the disease burden increases.... Northwestern University

10/05/17 / #20170283467

Programmable polypeptide and nucleic acid nanoparticles

Provided herein are polypeptides that self-assemble into nanoparticles upon binding to nucleic acids. The nanoparticles find use, for example in the delivery of the nucleic acids into cells.... Northwestern University

10/05/17 / #20170289707

Hearing assistance device control

A hearing assistance device may be a hearing aid worn on a person or a mobile device. The hearing assistance device may perform a hearing assistance algorithm based on signal processing parameters. A set of audiological values for a population may be identified. The set of audiological values has a... Northwestern University

09/28/17 / #20170275278

Mammalian and bacterial nitric oxide synthase inhibitors

Disclosed are compounds that are shown to inhibit the biological activity of nitric oxide synthases (NOSs). Also disclosed are pharmaceutical compositions comprising the compounds, and methods of using the compounds and pharmaceutical compositions for treating a subject in need thereof. Because the disclosed compounds are shown to inhibit the activity... Northwestern University

09/21/17 / #20170269172

Group iii-v ferromagnetic/non-magnetic semiconductor heterojunctions and magnetodiodes

Ferromagnetic Group III-V semiconductor/non-magnetic Group III-V semiconductor heterojunctions, with a magnetodiode device, to detect heterojunction magnetoresistance responsive to an applied magnetic field.... Northwestern University

09/21/17 / #20170269755

Haptic device with controlled traction forces

A haptic device comprising a substrate having a surface, a first actuator that modulates a friction experienced by a user's finger touching the substrate surface, a second actuator that oscillates the substrate surface laterally, such that the combined effect of the first and second actuator is a net shear force... Northwestern University

09/14/17 / #20170258870

Limp-2 based peptides and related uses

Disclosed are LIMP-2 peptides, LIMP-2 polypeptides, variants thereof, and pharmaceutical compositions comprising the LIMP-2 peptides, LIMP-2 polypeptides, or variants thereof. The disclosed peptides and polypeptides preferably comprise an amino acid sequence that is sufficient for providing a biological activity associated with LIMP-2, which may include binding and/or activating biological molecules... Northwestern University

09/14/17 / #20170258880

Peptide conjugated particles

The present invention provides compositions comprising peptide-coupled biodegradable poly(lactide-co-glycolide) (PLG) particles In particular, PLG particles are surface-functionalized to allow for coupling of peptide molecules to the surface of the particles (e.g., for use in eliciting induction of immunological tolerance).... Northwestern University

09/14/17 / #20170260165

2-imidazolyl-pyrimidine scaffolds as potent and selective inhibitors of neuronal nitric oxide synthase

Imidazolyl-pyrimidine and related compounds, as can utilize heme-iron coordination in the selective inhibition of neuronal nitric oxide synthase.... Northwestern University

09/14/17 / #20170260192

Compounds and methods for the prevention and treatment of tumor metastasis and tumorigenesis

The disclosure provides compounds for reducing the prevalence of the perinucleolar compartment in cells, for example, of formula (I), wherein R1, R2, R3, and R4 are as defined herein, that are useful in treating a disease or disorder associated with increased prevalence of the perinucleolar compartment, such as cancer. Also... Northwestern University

09/14/17 / #20170260587

Sqstm1 mutations in amyotrophic lateral sclerosis

Provided herein is technology relating to diagnosing, monitoring, and treating disease and particularly, but not exclusively, to methods, compositions, and kits for diagnosing, monitoring, and treating amyotrophic lateral sclerosis by detecting and identifying mutations in the gene SQSTM1 and providing therapies by targeting aberrant biological functions related to mutant forms... Northwestern University

Patent Packs
09/07/17 / #20170253486

Stable aqueous dispersions of optically and electronically active phosphorene

Methods for the preparation of few-layer phosphorene, compositions thereof and related devices fabricated therefrom.... Northwestern University

09/07/17 / #20170253581

Substituted heterocycles as c-myc targeting agents

Disclosed are substituted heterocycles compounds including substituted pyrazoles, substituted pyrimidines, and substitute triazoles. The substituted heterocycles disclosed herein are shown to be useful in inhibiting c-MYC and may be utilized as therapeutics for treating cancer and cell proliferative disorders.... Northwestern University

09/07/17 / #20170254817

Biomarkers in nasal exhaled breath

A method of diagnosing or assessing risk of a tauopathy in a person is disclosed. The method may comprise collecting a nasal sample of exhaled breath from the person's nose, analyzing the nasal sample to detect the presence of tau protein in the sample, and determining the concentration of tau... Northwestern University

08/31/17 / #20170249014

Interfaces and methods of digital composition and editing of textures for rendering on tactile surfaces

This disclosure provides designer interfaces that present condensed representations of texture functions, the representations displaying selected control points that manipulate the representations, an algorithm that computes a texture function based on the positions of said selected control points, and the texture function generating a signal to control a force on... Northwestern University

08/24/17 / #20170239202

(s)-3-amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic acid, and related compounds as gaba aminotransferase inactivators for the treatment of epilepsy, addiction and hepatocellular carcinoma

Cyclopentene carboxylic acid-related compounds as GABA-AT inhibitors for treatment of various addictions, disorders and disease states.... Northwestern University

08/17/17 / #20170232109

Protein/oligonucleotide core-shell nanoparticle therapeutics

The present disclosure is directed to core-shell nanoparticles, compositions comprising core-shell nanoparticles, and methods of their use.... Northwestern University

08/10/17 / #20170224239

Cycle length iteration for the detection of atrial activations from electrogram recordings of atrial fibrillation

A method is provided of analyzing a cardiac electrogram using a computer. In one step, a determination is made as to a plurality of cycle lengths between a plurality of activation peaks of the cardiac electrogram. In another step, a determination is made as to whether a mean of the... Northwestern University

08/10/17 / #20170227947

Automated toolpath generation double sided incremental forming

An automated method for generating toolpaths in double sided incremental forming (DSIF) operations is disclosed which uses a geometrically constructed map to build a structure of all the geometric features that is capable of tracking and forming the features in the correct order while simultaneously keeping track of the location... Northwestern University

08/10/17 / #20170229742

Protective cathode coatings for lithium-ion batteries

Cathode coatings for lithium ion batteries, cathodes coated with the coatings, and lithium ion batteries incorporating the coated cathodes are provided. The coatings, which are composed of binary, ternary, and higher order metal oxides and/or metalloid oxides, can reduce the hydrofluoric acid (HF)-induced degradation of the electrolyte and/or cathodes, thereby... Northwestern University

08/03/17 / #20170216249

Substituted phenyl aziridine precursor analogs for inhibiting androgen-independent prostate cancer cell growth

Disclosed are methods and pharmaceutical compositions for modulating one or more steroidal receptor activities. The methods typically utilize and the pharmaceutical compositions typically include one or more substituted phenyl aziridine precursors, their respective aziridines, analogs thereof, derivatives thereof, or pharmaceutically acceptable salts thereof such as CpdA. The methods and compositions... Northwestern University

08/03/17 / #20170217796

Compounds for lithium extraction via ion exchange

Methods for extracting lithium from solutions containing lithium ions via reversible cation exchange with H+ are provided. The methods utilize metal oxide or metalloid oxide cation exchange materials having an active sublattice that preferentially bind Li+ cations, relative to both H+ and Na+, in a sample solution and preferentially bind... Northwestern University

08/03/17 / #20170218135

Viologen-based rotaxanes

Disclosed herein are nanoactuating rotaxanes comprising a threading component, the threading component comprising a oligoviologen, and at least two macrocylic components, wherein the oligoviologen is threaded through each of the macrocylic components. Also disclosed are methods for making and using the rotaxanes.... Northwestern University

08/03/17 / #20170218174

Immobilization of an active agent on a substrate using compounds including trihydroxyphenyl groups

The invention provides methods of immobilizing an active agent to a substrate surface, including the steps of, providing a substrate, contacting the substrate with a solution of a compound including a trihydroxyphenyl group, thereby forming a trihydroxyphenyl-treated substrate, and contacting the trihydroxyphenyl-treated substrate with an active agent, thereby immobilizing the... Northwestern University

08/03/17 / #20170222724

Ultrafast all-optical modulation of the visible and infrared spectrum with nanorod arrays

Disclosed herein is a method of optical modulation, the method comprising irradiating an optical switch with a control beam at a first control time and irradiating the optical switch with a signal beam at a signal time. The transmitted intensity of the signal beam in a direction depends on the... Northwestern University

07/27/17 / #20170209252

Medical devices, systems, and kits for the medialization of a vocal cord

Medical devices, systems, methods, and kits for the medialization of a vocal cord are described. A method comprises creating a passageway in thyroid cartilage of a patient, advancing a light source through the passageway, activating the light source, viewing light emitted from the light source to confirm placement of the... Northwestern University

Patent Packs
07/27/17 / #20170209604

Method for detecting soluble oligomeric amyloid beta

A method for detecting soluble oligomeric amyloid β in a subject using, e.g., PET is provided.... Northwestern University

07/27/17 / #20170209622

Graphene-based ink compositions for three-dimensional printing applications

Electrically conducting, biocompatible, biodegradable tissue growth comprising graphene flakes in a polymeric matrix are provided.... Northwestern University

07/27/17 / #20170212992

Systems and methods for generating high resolution probabilistic raster maps for electronic health record and other data associated with a geographical region

Described here are systems and methods for generating probabilistic maps that depict the probability distribution of data across a geographical region. More particularly, the systems and methods described here are capable of generating probabilistic maps of associated data at finer geographical resolution than is available for the associated data and... Northwestern University

07/27/17 / #20170213355

Method for acquiring intentionally limited data and the machine learning approach to reconstruct it

Aspects of the present disclosure involve a data capturing and processing system that intentionally captures data and/or data sets with missing pieces of information. The data and/or datasets may include various types of data, such as one-dimensional signals, two-dimensional images (or other images), and/or three-dimensional structures. The captured data is... Northwestern University

07/20/17 / #20170203369

Synthesis of uniform anisotropic nanoparticles

Methods of synthesizing various metal nanoparticle structures having high uniformity, using iterative reduction and oxidation conditions, is provided herein.... Northwestern University

07/20/17 / #20170205401

Yeast-based biosensor

Provided herein are compositions and systems comprising yeast-based biosensors (YBBs) and methods of use thereof. In particular, YBBs are provided for the detection and/or quantification of an analyte (e.g., peptide analyte) in a sample (e.g., a biological sample, environmental sample, etc.). In some embodiments, provided herein are diagnostic compositions, devices,... Northwestern University

07/13/17 / #20170198290

Anti-inflammatory treatment via inhibition of endothelial cell kinesin light chain 1, variant 1 (klc1c)

Provided herein are compositions and methods for the inhibition of endothelial cell kinesin light chain 1, variant 1 (KLC1C) expression and/or activity, and treatment or prevention of inflammation therewith.... Northwestern University

07/06/17 / #20170188818

Devices, methods, and systems of functional optical coherence tomography

The present disclosure provides systems and methods for the determining a rate of change of one or more analyte concentrations in a target using non invasive non contact imaging techniques such as OCT. Generally, OCT data is acquired and optical information is extracted from OCT scans to quantitatively determine both... Northwestern University

07/06/17 / #20170189890

Carbohydrate-mediated purification of petrochemicals

A separation medium consisting of a cyclodextrin metal-organic framework (CD-MOF) for separating aromatic compounds and methods of preparing the same are presented. Bottom-up preparations include the following steps: (a) preparing a first mixture comprising a cyclodextrin, an alkali metal salt, water and an alcohol; (b) performing one of the following... Northwestern University

07/06/17 / #20170191128

Tissue molecular signatures of kidney transplant rejection

By a genome-wide gene analysis of expression profiles of known or putative gene sequences in kidney biopsy samples, the present inventors have identified a consensus set of gene expression-based molecular biomarkers for distinguishing kidney transplantation patients who have Acute Rejection (AR), Acute Dysfunction No Rejection (ADNR), Chronic Allograft Nephropathy(CAN), or... Northwestern University

07/06/17 / #20170194765

Monolithical widely tunable quantum cascade laser devices

Monolithic, wavelength-tunable QCL devices are provided which comprise a substrate, an array of QCLs formed on the substrate and an optical beam combiner formed on the substrate electrically isolated from the array of QCLs. In embodiments, the QCL devices are configured to provide laser emission in the range of from... Northwestern University

07/06/17 / #20170194982

System and energy efficient time domain signal processing

Time domain signal processing (TDSP) encodes information into time rather than voltage with high efficiency. Circuit level design techniques can also reduce the area and energy consumption of TDSP. Design examples on both conventional signal processing blocks and emerging facial recognition applications can be used to demonstrate the potential of... Northwestern University

06/29/17 / #20170182018

Treatment for dopaminergic disorders

The present invention provides systems, compositions and methods for treatment of dopaminergic disorders (e.g., Parkinson's disease) using the combination of a first compound that inhibits a voltage-gated calcium channel of the type Cav1.3 (e.g., a dihydropyridine such as isradipine), and a second compound that is monoamine oxidase inhibitor and/or is... Northwestern University

06/29/17 / #20170183735

Molecular signatures for distinguishing liver transplant rejections or injuries

By a genome-wide gene analysis of expression profiles of known or putative gene sequences in peripheral blood and biopsy samples, the present inventors have identified a consensus set of gene expression-based molecular biomarkers for distinguishing liver transplantation patients who have Acute Rejection (AR), Hepatitis C Virus Recurrence (HCV-R), both AR/HCV-R,... Northwestern University

06/22/17 / #20170172440

Contribution of oxidative stress to af electrograms

The invention relates generally to methods of detecting reactive oxygen species (ROS) in cardiac tissue and treatment modalities for ablating ROS-associated tissue in cardiac disease. The methods rely upon targeting ROS-associated cardiac tissue for ablation and/or gene therapy in a subject using analytical tools based upon a plurality of recorded... Northwestern University

06/22/17 / #20170173226

Immobilization of an active agent on a substrate

The invention provides methods of immobilizing an active agent to a substrate surface, including the steps of, depositing a primer compound on a substrate, thereby forming a primed substrate, contacting the primed substrate with a solution of a compound including a trihydroxyphenyl group, thereby forming a trihydroxyphenyl-treated primed substrate, and... Northwestern University

06/22/17 / #20170173333

Methods of frequency-modulated phase coding (fmpc) for cochlear implants and cochlear implants applying same

A cochlear implant includes electrodes and a processor for generating frequency-modulated electrical pulse trains in one or more of the electrodes responsive to dividing data representing audio spanning frequency-bands into bins associated with each frequency-band, each bin representing an energy level of the data within the frequency-band within a time-period;... Northwestern University

06/22/17 / #20170181112

System and resolving neighborhood wireless network affairs with radio signals

A system and method include a wireless node with a scheduler and a harmonizing controller connected with the node. The harmonizing controller includes a processor and a memory, where the memory stores instructions, which when executed by the processor, causes the processor to receive a radio signal, process the radio... Northwestern University

06/15/17 / #20170166756

Surface-independent, surface-modifying, multifunctional coatings and applications thereof

The present invention provides a surface-independent surface-modifying multifunctional biocoating and methods of application thereof. The method comprises contacting at least a portion of a substrate with an alkaline solution comprising a surface-modifying agent (SMA) such as dopamine so as to modify the substrate surface to include at least one reactive... Northwestern University

06/15/17 / #20170168572

Haptic display with simultaneous sensing and actuation

Touch interface devices and methods for producing multi-point haptics utilizing simultaneous sensing and actuation are disclosed. In one configuration, one or more electrodes connected to a front surface of a substrate are arranged in a pattern and connected to an electronic controller configured to produce a haptic effect by applying... Northwestern University

06/08/17 / #20170162628

Ultralow power carbon nanotube logic circuits and making same

A method of fabricating a CMOS logic device with SWCNTs includes forming a plurality of local metallic gate structures on a substrate by depositing a metal on the substrate; forming a plurality of contacts on the substrate; and depositing the SWCNTs on the substrate, and doping a certain area of... Northwestern University

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