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Northwestern University patents


Recent patent applications related to Northwestern University. Northwestern University is listed as an Agent/Assignee. Note: Northwestern University may have other listings under different names/spellings. We're not affiliated with Northwestern University, we're just tracking patents.

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Inactivators of toxoplasma gondii ornithine aminotransferase for treating toxoplasmosis and malaria

Disclosed are methods, compounds, and compositions for treating infection by an Apicomplexan parasite that include administering a compound that selectively inactivates ornithine aminotransferase of the Apicomplexan parasite. Specifically, the methods, compounds, compounds may be utilized for treating infection by Toxoplasma gondii and toxoplasmosis and for treating infection by Plasmodium falciparum... Northwestern University

Biomimetic and variable stiffness ankle system and related methods

A cam system for an assistive device and related methods are disclosed. The cam system may comprise a cam profile and a cam follower. The cam profile has a curved outer edge comprising a concave portion. The cam follower is positioned within the concave portion when the assistive device is... Northwestern University

Treatment of eosinophilic inflammatory disease

Provided herein are compositions and methods for the treatment of eosinophilic inflammatory diseases of the mucosal surfaces using proton pump inhibitors. In particular, administration of inhibitors of H,K-ATPase (ATP12A) provides treatment for eosinophilic inflammatory diseases.... Northwestern University

Nanocarriers having surface conjugated peptides and uses thereof for sustained local release of drugs

Disclosed are biodegradable nanocarriers that have a net positive surface charge and zeta potential between about +2 to about +20 mV. The positive surface charge of the nanocarriers is provided by peptides that are covalently attached to the surface of the nanocarriers. The nanocarriers may comprise a drug and may... Northwestern University

Methods of treating depression and other related diseases

The invention relates to methods for treating depression, anxiety, and other related diseases by administering a peptide NMDAR partial agonist.... Northwestern University

System and secure query processing for private data networks

Systems and methods enable two or more data providers that do not trust each other with their data to pool their data for analysis. The systems and methods can translate conventional database SQL queries into secure multiparty computation so that the data providers can analyze their collective data without requiring... Northwestern University

Polyvalent rna-nanoparticle compositions

The present invention concerns nanoparticles functionalized with duplex RNA for a variety of uses, including but not limited to gene regulation. More specifically, the disclosure provides a new strategy for conjugating RNA to a nanoparticle to achieve increased stability and activity.... Northwestern University

Antioxidant scaffolds for beta cell delivery

Provided herein are thermoresponsive citrate-based hydrogels and methods of use thereof for cell delivery. In particular, pancreatic islet cells entrapped within poly(polyethyleneglycol citrate-co-N isopropylacrylamide) (PPCN) hydrogels are provided herein, as well as methods of use thereof for extra-hepatic islet transplantation.... Northwestern University

Tissue factor (tf)-targeted nanotherapy

Provided herein are tissue factor (TF)-targeted nanofibers and methods of treating hemorrhage in a subject therewith. In particular, peptide amphiphiles (PAs) are provided that comprise a TF-targeting peptide sequence and self-assemble under aqueous conditions into PA nanofibers displaying the TF-targeting sequence on the exterior of the nanofiber.... Northwestern University

Altered microbiome of chronic pelvic pain

Provided herein are kits, compositions, and methods for diagnosing and treating interstitial cystitis (IC) and/or interstitial cystitis/bladder pain syndrome (IC/BPS) based on finding lower levels of certain bacteria in a subject's stool sample (e.g., O. splanchnicus, F. prausnitzii, C. aerofaciens, E. sinensis, L. longoviformis, and R. intestinalis). In certain embodiments,... Northwestern University

Devices, methods, and systems relating to super resolution imaging

Generally, spectroscopic super-resolution microscopic imaging may comprise resolving one or more non-diffraction limited images of an area of a test sample by acquiring both localization information of a subset of molecules using microscopic methods known in the art, and simultaneously or substantially simultaneously, acquiring spectral data about the same or... Northwestern University

Indirect attachment of a needle to a mesh suture

A medical device includes a surgical needle, an elongated suture, and an intervening segment. The elongated suture has a first end proximate to the needle and a second end located away from the needle. The elongated suture also includes a plurality of fibers defining a mesh wall between the first... Northwestern University

Ink compositions for fabricating objects from regoliths and methods of forming the objects

Ink compositions for fabricating objects from planetary regoliths and objects fabricated from the ink compositions are provided. The objects include flexible, elastomeric objects and hard objects. Also provided are methods, including three-dimensional (3D) printing methods, for fabricating objects using the ink compositions. The ink compositions comprise a natural planetary regolith,... Northwestern University

Compositions and methods for correcting limb girdle muscular dystrophy type 2c using exon skipping

The invention is directed to one or more antisense polynucleotides and their use in pharmaceutical compositions in a strategy to induce exon skipping in the γ-sarcoglycan gene in patients suffering from Limb-Girdle Muscular Dystrophy-2C (LGM-D2C) or in patients at risk of such a disease. The invention also provides methods of... Northwestern University

Nanopatterned extracellular matrices enable cell-based assays with a mass spectrometric readout

The present disclosure provides methods in which adherent cells are treated with small molecules, cultured, lysed, and then analyzed by mass spectrometry to measure the activities of endogenous enzymes. The implementation of this method relies on the use of surfaces that are nanopatterned with cell adhesion ligands to mediate cell... Northwestern University

Stress manipulated coating for figure reshape of optical substrates

A deposition system for forming a stress distributed coating layer is provided which comprises a deposition apparatus comprising a source from which a coating material emanates, the source configured to restrict a flux of the coating material towards a backside of an optical substrate; a holder configured to hold the... Northwestern University

Compositions and methods for identifying depressive disorders

Provided herein are compositions, kits, and methods for the identification of depressive disorders. In particular, provided herein are compositions, kits, and methods for the detection or diagnosis of major depressive disorder.... Northwestern University

Devices and methods for filtering blood plasma

The present invention provides systems, devices, kits, and methods for separating blood plasma from whole blood. In particular, the present invention provides systems, devices, and methods for separating a fixed volume of blood plasma from whole blood with minimal energy input.... Northwestern University

Nanoparticles as catalytic substrates for real-time biosensing of human performance and diagnostic and therapeutic methods

Nanostructures having an inorganic core and a lipid layer capable of binding a lecithin:cholesterol acyltransferase (LCAT) activator such as an apolipoprotein are provided herein. Methods of using the nanostructures and related devices and compositions for assessing the risk of developing a disease or condition or treating the disease or condition... Northwestern University

Soft, wearable microfluidic systems capable of capture, storage, and sensing of biofluids

The invention provides systems for handling biofluids including the transport, capture, collection, storage, sensing, and/or evaluation of biofluids released by tissue. Systems of some aspects provide a versatile platform for characterization of a broad range of physical and/or chemical biofluid attributes in real time and over clinically relevant timeframes. Systems... Northwestern University

Methods and compositions for modulating calcium channels

The present invention relates to methods and compositions for modulating calcium channels. In particular, the present invention provides methods and compositions for modulating (e.g., disrupting) Cav1.3a calcium channels for research and therapeutic methods (e.g., treating dopaminergic diseases and conditions).... Northwestern University

3d microphysiologic system

The present invention relates generally to a three-dimensional cell and tissue culture system for the female reproductive tract. In particular provided herein the system includes individual female reproductive cultures in a dynamic microfluidic setting or integrated using a microfluidic microphysiologic system. In some embodiments, the present invention provides ex-vivo female... Northwestern University

Compositions and methods for identifying depressive disorders

Provided herein are compositions, kits, and methods for the identification of depressive disorders. In particular, provided herein are compositions, kits, and methods for the detection or diagnosis of major depressive disorder.... Northwestern University

Heat actuated and projected lithography systems and methods

In accordance with an embodiment of the disclosure, a tip array can include an elastomeric tip substrate layer comprising a first surface and an oppositely disposed second surface, the tip substrate layer being formed from an elastomeric material; a plurality of tips fixed to the first surface, the tips each... Northwestern University

Touch interface device and applying controllable shear forces to a human appendage

A method of moving a plurality of appendages of an operator in contact with a touch surface including the steps of measuring a plurality of locations when the touch surface is touched by the plurality of appendages, moving the touch surface in a swirling motion by one or more actuators... Northwestern University

Sorting process of nanoparticles and applications of same

A sensing platform includes a substrate, an array of wells formed in the substrate, and sorted nanoparticles filling in the array of wells such that each well contains a single sorted nanoparticle, wherein the sorted nanoparticles are in a cluster state.... Northwestern University

Tetrahydrothiophene-based gaba aminotransferase inactivators

Tetrahydrothiophene and related heterocyclic analogs and related methods for GABA aminotransferase inactivation.... Northwestern University

Non-neuroinvasive viruses and uses thereof

Provided herein are compositions and methods for vaccination and research applications. In particular, provided herein are non-neuroinvasive herpesviruses and alpha herpesviruses and uses thereof.... Northwestern University

Substituted 4-methyl-pyrrolo[1,2-a]pyrimidine-8-carboxamide compounds and uses thereof for modulating glucocerebrosidase activity

Disclosed are new small molecules having a 4-methylpyrrrolo[1,2-a]pyrimidine-8-carboxamide core structure and the uses thereof for modulating glucocerebrosidase activity. Also disclosed are pharmaceutical compositions comprising the small molecules which may be administered in methods of treating diseases or disorders associated with glucocerebrosidase activity, including neurological diseases and disorders such as Gaucher's... Northwestern University

Raman and surface enhanced raman spectroscopy for monitored drugs

The present disclosure provides systems, methods, and kits for identifying and determining the concentration of a drug of interest suspected of being present in an intravenous drug solution. An electrochemical surface enhanced Raman (EC-SERS) substrate is used to acquire an EC-SERS spectrum of the intravenous drug solution. The EC-SERS spectrum... Northwestern University

System and acquiring both t2*-weighted and t1-weighted data in a single acquisition using a single dose of contrast agent

Described here are systems and methods for obtaining measurements of both tissue perfusion and permeability with a magnetic resonance imaging (“MRI”) system after the administration of a single dose of contrast agent. To this end, the MRI system is directed to acquire T2-weighted or T2*-weighted data, during which the acquired... Northwestern University

Touch interface device having an electrostatic multitouch surface and controlling the device

A touch interface device comprising a touch surface, a first electrode coupled with the touch surface, a second electrode coupled with the touch surface, where when an appendage of an operator touches the touch surface above both the first electrode and the second electrode a first actuation electrical potential from... Northwestern University

Noncentrosymmetric metal electrodes for ferroic devices

A ferroelectric heterostructure may comprise a ferroelectric layer comprising a ferroelectric material and a first electrode layer comprising a first noncentrosymmetric metal, the first electrode layer disposed on the ferroelectric layer to form a ferroelectric-first electrode interface, wherein the ferroelectric layer is characterized by exhibiting an electric polarization and the... Northwestern University

Nanostructure enhanced targeting (nset) of inflammatory cells

The present invention provides nanomaterials for the specific targeting of immune cells. Methods of treating cardiac disease and inflammatory disease are also described.... Northwestern University

Biomarkers predictive of predisposition to depression and response to treatment

The present invention relates generally to the identification of subjects with a predisposition to recurrent depression, predicting a subject's responsiveness to therapy, and determining whether a subject has remitted from depression following therapy. In particular, provided herein are biomarkers, methods, and kits for such uses.... Northwestern University

02/01/18 / #20180030539

Biomarkers predictive of predisposition to depression and response to treatment

The present invention relates generally to the identification of subjects with a predisposition to recurrent depression, predicting a subject's responsiveness to therapy, and determining whether a subject has remitted from depression following therapy. In particular, provided herein are biomarkers, methods, and kits for such uses.... Northwestern University

02/01/18 / #20180031583

Phosphatidylethanolamine-specific probes

Provided herein are phosphatidylethanolamine (PE)-specific probes and methods of use thereof. In particular, the present invention provides conjugates of PE binding moieties with detectable markers, and methods of use thereof to detect and/or characterize PE within cells.... Northwestern University

02/01/18 / #20180031662

System and mapping and quantifying in-vivo blood flow stasis

Described here are systems and methods for producing an image that depicts blood flow stasis using magnetic resonance imaging (MRI), Doppler echocardiography, or other medical instruments for measuring flow velocities in a human body. A time series of three-dimensional (3D) image volumes is provided, where this time series of 3D... Northwestern University

01/25/18 / #20180020922

Devices, methods, and systems of functional optical coherence tomography

The present disclosure provides systems and methods for the determining a rate of change of one or more analyte concentrations in a target using non invasive non contact imaging techniques such as OCT. Generally, OCT data is acquired and optical information is extracted from OCT scans to quantitatively determine a... Northwestern University

01/25/18 / #20180021040

Mesh suture

A medical device includes a surgical needle attached to an elongated mesh suture. The suture is constructed of macroporous flat wall that facilitates and allows tissue integration into the suture core subsequent to introduction to the body, thereby preventing suture pull-through and improving biocompatibility.... Northwestern University

01/25/18 / #20180022878

Facile assembly of soft nanoarchitectures and co-loading of hydrophilic and hydrophobic molecules via flash nanoprecipitation

Described herein are flash nanoprecipitation methods capable of encapsulating hydrophobic molecules, hydrophilic molecules, bioactive protein therapeutics, or other target molecules in amphiphilic copolymer nanocarriers.... Northwestern University

01/25/18 / #20180025124

Systems and methods for identifying content based on user interactions

Disclosed is an intelligent recommendation system for identifying and/or providing personalized one or more independent applications and/or healthcare related media content (e.g., multimedia content and applications involved in healthcare or the treatment of various health conditions of a user) to a plurality of user devices and/or client devices.... Northwestern University

01/18/18 / #20180016548

Acellular scaffolds for maturation of ipsc-hepatocytes

Provided herein are compositions and systems comprising induced pluripotent stem cell (iPSC)-derived hepatocytes and systems and methods for acellular maturation thereof. In particular, iPSC-derived hepatocytes are matured on decellularized extracellular matrix (ECM) to yield cells with enhanced hepatocytic biomarkers and functionality.... Northwestern University

01/18/18 / #20180016612

Method for rapid in vitro synthesis of bioconjugate vaccines via recombinant production of n-glycosylated proteins in prokaryotic cell lysates

Disclosed are methods, systems, components, and compositions for cell-free synthesis of glycosylated proteins. The glycosylated proteins may be utilized in vaccines, including anti-bacterial vaccines. The glycosylated proteins may include a bacterial polysaccharide conjugated to a carrier, which may be utilized to generate an immune response in an immunized host against... Northwestern University

01/18/18 / #20180016614

Highly productive one-pot system for the incorporation of non-standard amino acids into cell-free synthesized proteins

Disclosed are methods, systems, components, and compositions related to genomically recoded and engineered organisms. The disclosed genomically recoded and engineered organisms may be used to prepare extracts for use in platforms and methods for preparing sequence defined biopolymers in vitro. In particular, the methods, systems, components, and compositions relate to... Northwestern University

01/18/18 / #20180016623

Compositions and methods for detecting nucleic acids in sputum

This disclosure relates generally to methods and kits useful for preparing samples, extracting nucleic acids from samples (e.g., biological samples), and/or detecting nucleic acids (e.g., pathogen nucleic acids) in samples (e.g., samples obtained from a subject). In particular, compositions, kits, and methods are provided comprising detergents and proteinases to treat... Northwestern University

01/18/18 / #20180017487

Biological tissue analysis by inverse spectroscopic optical coherence tomography

A method and system to measure and image the full optical scattering properties by inverse spectroscopic optical coherence tomography (ISOCT) is disclosed. Tissue is modeled as a medium with continuous refractive index (RI) fluctuation and such a fluctuation is described by the RI correlation functions. By measuring optical quantities of... Northwestern University

01/18/18 / #20180019493

Three dimensional extrusion printed electrochemical devices

Solid oxide electrochemical devices, methods for making the electrochemical devices, and methods of using the electrochemical devices are provided. The electrochemical devices comprise a plurality of stacked functional layers that are formed by a combination of three-dimensional (3D) extrusion printing and two-dimensional (2D) casting techniques.... Northwestern University

01/11/18 / #20180008156

Systems, methods, and esophageal panometry

Systems, methods, and apparatus for esophageal panometry are provided. An example method includes capturing measurement data including an area and a pressure of an esophageal body via a measurement device positioned with respect to the esophageal body; generating representations of the exported measurement data; analyzing the measurement data to determine... Northwestern University

01/11/18 / #20180009870

Therapeutic targeting of set1b/compass pathway for treating cancers

Disclosed are methods for treating Set1/COMPASS-associated cancers characterized by expression of Set1B/COMPASS. The methods typically include administering a therapeutic amount of an inhibitor of the Set1B/COMPASS pathway and/or an agonist for a target that is negatively regulated by the Set1B/COMPASS pathway.... Northwestern University

01/11/18 / #20180010001

Enhanced conductivity, adhesion and environmental stability of printed graphene inks with nitrocellulose

Graphene ink compositions comprising nitrocellulose and related methods of use comprising either thermal or photonic annealing.... Northwestern University

01/11/18 / #20180011571

Haptic device with indirect haptic feedback

A method of imitating a texture on a touch surface, the method including the steps of sensing a position of a user's finger on the touch surface, modulating a coefficient of friction of the touch surface in response to the sensed position of a user's appendage relative to the touch... Northwestern University

01/11/18 / #20180013065

Optical discs as low-cost, quasi-random nanoimprinting templates for photon management

Photonic devices are provided comprising a photoactive layer and at least one additional layer, wherein a surface of the photoactive layer or a surface of the at least one additional layer has imprinted thereon a quasi-random pattern of nanostructures corresponding to a quasi-random pattern of nanostructures defined in a recording... Northwestern University

01/04/18 / #20180001581

Compositions, patient specific ophthalmic device

Systems, methods, and devices to fabricate one or more device components are disclosed. An example method includes fabricating one or more subject specific device components generated from receiving one or more images of one or more features of the first eye of the subject; designing a three dimensional virtual geometric... Northwestern University

12/28/17 / #20170367596

Tonometry based blood pressure measurements using a two-dimensional force sensor array

Representative methods, apparatus and systems are disclosed for blood pressure and other vital sign monitoring using arterial applanation tonometry, including ambulatory blood pressure and other vital sign monitoring. A representative system comprises a wearable apparatus. The various embodiments measure blood pressure and other vital sign monitoring using a plurality of... Northwestern University

12/28/17 / #20170367982

High density lipoprotein functionalized magnetic nanostructures

Provided herein are compositions and methods for diagnosis and treatment of early-stage atherosclerotic plaques and reduction of plaques in arteries. In particular, provided herein are high-density-lipoprotein-functionalized magnetic nanostructures (HDL-MNS) capable of (i) precise anatomic detection of atherosclerotic lesions, (ii) removal of excess cholesterol from macrophage cells in atherosclerotic plaque, and/or... Northwestern University

12/28/17 / #20170368377

Photoluminescent panthenol citrate biomaterials

Provided herein are compositions comprising panthenol-citrate containing materials. In particular, panthenol citrate compounds, oligomers, and polymers, and methods of use and synthesis thereof, are provided herein. Panthenol-citrate containing materials are a class of nontoxic, photoluminescent-chromophore-containing compounds, oligomers, and polymers with high absorption in the UVA and UVB range that can... Northwestern University

12/28/17 / #20170369472

Map kinase modulators and uses thereof

The invention provides for novel MAP kinase inhibitors and compositions comprising the same. In some embodiments, the MAP kinase inhibitors are p38α MAP kinase inhibitors. The invention further provides for methods for treatment of diseases comprising administration of MAP kinase inhibitors or compositions comprising MAP kinase inhibitors. In some embodiments,... Northwestern University

12/28/17 / #20170369851

Artificial ovary

Artificial ovaries comprising porous three-dimensional scaffolds are provided. Also provided are ink compositions and methods for printing the scaffolds. The artificial ovaries have spatial arrangements and cellular compositions that allow them to mimic native ovarian tissue. As such, they can be cultured or transplanted to support female endocrine function and/or... Northwestern University

12/21/17 / #20170360992

Thromboresistant-anticoagulant extracellular matrix

Provided herein are bioactivated polymer/extracellular matrix (ECM) composites and methods of preparation and use thereof. In particular, heparinized cysteine-polymer/ECM composites, and methods of preparation and use thereof, are provided. In some embodiments, provided herein are compositions comprising a composite of: (a) extracellular matrix (ECM), and (b) a polyester covalently linked... Northwestern University

12/21/17 / #20170362167

Zirconium- and hafnium-based metal-organic frameworks as epoxide ring-opening catalysts

Metal-organic frameworks (MOFs) and method of using the MOFs to catalyze reactions involving epoxide ring-opening mechanisms are provided. The structure of the MOFs can be represented by the formula: M6(μ3-ligand)8(OHx)8(TBAPy)2, where M is Zr or Hf, the ligands are selected from hydroxo-, oxo- and aquo-ligands, and x is independently selected... Northwestern University

12/21/17 / #20170365557

Self-similar and fractal design for stretchable electronics

The present invention provides electronic circuits, devices and device components including one or more stretchable components, such as stretchable electrical interconnects, electrodes and/or semiconductor components. Stretchability of some of the present systems is achieved via a materials level integration of stretchable metallic or semiconducting structures with soft, elastomeric materials in... Northwestern University

12/14/17 / #20170354420

Intranasal occlusion device and methods of using the same

An intranasal occlusion device having an inflatable balloon within a sponge that is used to prevent drainage of fluid, such as blood and other fluids into the airway during sinus and nasal minor procedures or surgeries, and methods of using the device to occlude an intranasal cavity of a patient.... Northwestern University

12/14/17 / #20170354711

High density lipoprotein nanoparticles for inflammation

The invention in aspects relates to methods of treating sepsis using HDL-NP. The methods include the use of nanoparticles having a core and a lipid based shell with optimal lipids therein.... Northwestern University

12/14/17 / #20170355722

Arsenoplatin anti-cancer agents

M is Pt, Pd or Ni; Q is As, Sb or Bi; Z1 is N; Z2 is O or S; L1 and L2 are independently C(O), C—R1 or C—R2; X is a Lewis base; Y1 and Y2 are independently selected from —OR3, —OR4, —SR3 and —SR4, wherein R1 and R2... Northwestern University

Patent Packs
12/14/17 / #20170358795

Electrode material comprising graphene-composite materials in a graphite network

A durable electrode material suitable for use in Li ion batteries is provided. The material is comprised of a continuous network of graphite regions integrated with, and in good electrical contact with a composite comprising graphene sheets and an electrically active material, such as silicon, wherein the electrically active material... Northwestern University

12/07/17 / #20170349552

Treatment of amyotrophic lateral sclerosis

The present invention relates to the identification of compounds and pharmaceutical compositions thereof for treating subjects with amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. The invention also provides methods of preparing the provided compounds.... Northwestern University

12/07/17 / #20170349928

Methods for activating natural energy metabolism for improving yeast cell-free protein synthesis

Disclosed are compositions, methods, and kits for enhanced synthesis of a biological macromolecule in vitro using cell-free protein synthesis. The compositions, methods, and kits include or utilize: a cell-free extract; a phosphate-free energy source; and a phosphate source, and typically do not include an exogenous nucleoside triphosphate or an exogenous... Northwestern University

12/07/17 / #20170351318

System and associative power and clock management with instruction governed operation for power efficient computing

A system includes an ARM core processor, a programmable regulator, a compiler, and a control unit, where the compiler uses a performance association outcome to generate a 2-bit regulator control values encoded into each individual instruction. The system can provide associative low power operation where instructions govern the operation of... Northwestern University

12/07/17 / #20170352151

Spatiotemporal background phase correction for phase contrast velocity encoded mri

A computer-implemented method for performing spatiotemporal background phase correction for phase contrast velocity encoded magnetic resonance imaging includes performing a phase contrast magnetic resonance imaging scan of a region of interest within a patient to yield a complex image and calculating a plurality of filter cut-off frequencies based on physiological... Northwestern University

11/30/17 / #20170344119

Haptic touch screen and operating the same

A haptic touch screen including a lower layer including a plurality of control electrodes, an upper layer including a plurality of haptic electrodes, a middle layer between the lower layer and upper layer, where the haptic electrodes are not conductively connected to control electronics.... Northwestern University

11/23/17 / #20170332935

Methods and systems for identifying non-penetrating brain injuries

The present disclosure provides methods for identifying non-penetrating brain injury in a subject, as well as methods for classifying a subject that received a hit to the body that transmitted an impulsive force to the brain as either having a non-penetrating brain injury or not, by analyzing one or more... Northwestern University

11/23/17 / #20170335335

Systems and methods for untargeted metabolomic screening

Provided herein are systems and methods for untargeted screening of metabolite products of biosynthetic gene clusters. In particular, systems and methods are provided for the detection of secondary metabolites and the correlation off such metabolites to the biosynthetic gene clusters responsible for the biosynthesis thereof.... Northwestern University

11/09/17 / #20170319650

Maspin-based inhibition of osteoclast activity and promotion of bone formation

Provided herein are compositions and methods for the treatment of bone disorders through the maspin-based inhibition of osteoclastogenesis and osteoclast activity and the promotion of bone formation.... Northwestern University

11/02/17 / #20170312284

Analogs of adenosine monophosphate (amp) as inhibitors of ubiquitin-like modifier-activating enzyme atg7

Disclosed are analogs of adenosine monophosphate (AMP) as inhibitors of ubiquitin-like modifier-activing enzyme ATG7. The AMP analogs may be formulated as pharmaceutical compositions for treating diseases or disorders that depend on ATG7 activity and/or autophagy such as cell proliferative diseases and disorders.... Northwestern University

11/02/17 / #20170312349

Peptide conjugated particles

The present invention provides compositions comprising peptide-coupled biodegradable poly(lactide-co-glycolide) (PLG) particles. In particular, PLG particles are surface-functionalized to allow for coupling of peptide molecules to the surface of the particles (e.g., for use in eliciting induction of immunological tolerance).... Northwestern University

11/02/17 / #20170312365

Short interfering rna templated lipoprotein particles (sirna-tlp)

Nanostructures for the systemic delivery of nucleic acids, such as RNA, are provided herein. The nanostructures include templated lipoprotein nanoparticles (TLPs) composed of a core decorated with proteins, a lipid bilayer and hydrophobic molecules that self-assemble with nucleic acids, such as RNA. The nanostructures are useful for research, therapeutic and... Northwestern University

11/02/17 / #20170313747

Self-assembled nanostructures

The present disclosure is directed to the preparation of nanostructures by the encapsulation of a charged compound with individual self-assembled unit nanostructures.... Northwestern University

10/26/17 / #20170304232

Endoxifen for local transdermal therapy to the breast

Disclosed are methods and topical formulations for treating and/or preventing cell proliferative diseases and disorders including breast cancer and ductal carcinoma is situ (DCIS) using local transdermal therapy (LTT). The disclosed methods typically include administering topically to the breast or breasts of the patient a topical formulation comprising an effective... Northwestern University

10/26/17 / #20170304587

Phase-locked loop to enhance slow wave sleep

Certain examples provide systems and methods to enhance slow wave sleep. An example method includes identifying a sleep stage for slow wave sleep in a subject being monitored. The example method also includes generating, following identification of slow wave sleep and using a processor including a phase locked loop, an... Northwestern University

Patent Packs
10/26/17 / #20170305813

Sulfur as a selective oxidant in oxidative hydrocarbon processing over oxide/chalcogenide catalysts

Methods for oxidative coupling of methane using metal oxide catalysts and a sulfur oxidant.... Northwestern University

10/26/17 / #20170305901

Therapeutic targeting of interleukin-1 receptor-associated kinase 4 (irak4) in cancers characterized by rearrangements in the mixed lineage leukemia gene (mll-r)

Disclosed are methods for treating cancers associated with rearrangements in the mixed lineage leukemia gene (MLL-r), including MLL-r leukemia. The methods typically include administering a therapeutic amount of one or more therapeutic agents that inhibit the biological activity of one or more members of the interleukin-1 signaling pathway such inhibitors... Northwestern University

10/26/17 / #20170305998

Modified pigment epithelium-derived factor (pedf) peptides and uses thereof for treating neovascular diseases, inflammatory diseases, cancer, and for cytoprotection

Disclosed are modified pigment epithelium-derived factor (PEDF) peptides, particulate carrier prodrugs thereof, and pharmaceutical compositions comprising the peptides or particulate carrier prodrugs. The peptides, particulate carrier prodrugs, and pharmaceutical compositions may be used to treat diseases and disorders that are amenable to treatment with anti-angiogenic agents, anti-tumorigenic agents, anti-fibrotic agents,... Northwestern University

10/26/17 / #20170306258

Lubricant additives, lubricant compositions, and applications of same

A lubricant composition includes a base lubricant and a plurality of lubricant additive molecules. Each lubricant additive molecule includes a surface active group attractable to a target surface, and a carbon containing component connected to the surface active group, for providing a carbon source to form a carbon film on... Northwestern University

10/26/17 / #20170306320

Methods for in vitro ribosome synthesis and evolution

Disclosed are methods, components, compositions, and kits for preparing and identifying engineered E. coli ribosomes. The E. coli ribosomes may be prepared and identified under a set of defined conditions, such as in the presences of antibiotics, in order to obtain an engineered ribosome that is resistant to the antibiotic.... Northwestern University

10/26/17 / #20170307440

Devices, methods, and systems relating to super resolution imaging

Certain examples disclose systems and methods for imaging a target. An example method includes: a) activating a subset of light-emitting molecules in a wide field area of a target using an excitation light; b) capturing one or more images of the light emitted from the subset of the molecules illuminated... Northwestern University

10/26/17 / #20170308597

Systems and methods for enabling situational awareness for events via data visualization

Aspects of the present disclosure relate to data visualization, and more specifically, to technology that automatically visualizes various analytics and predictions generated for mass participation endurance events, or other events of interest.... Northwestern University

10/26/17 / #20170309747

System and threshold logic with electrostatically formed nanowire transistors

An electrostatically formed nanowire transistor, includes a source, a drain, and multiple gates surrounding a doped silicon region. The gates include a top gate, a bottom gate, and side gates. The gates induce a channel in said doped silicon region. The channel has a width which is decreased by negative... Northwestern University

10/19/17 / #20170297988

Efficient catalytic greenhouse gas-free hydrogen and aldehyde formation from alcohols

Catalytic preparation of hydrogen and aldehyde(s) from alcohols, including bioalcohols, without production of carbon monoxide or carbon dioxide.... Northwestern University

10/19/17 / #20170298021

2-aminopyridine-based selective neuronal nitric oxide synthase inhibitors

Aminopyridine compounds, as can be used in conjunction with methods for modulation of nitric oxide synthase activity.... Northwestern University

10/19/17 / #20170299706

System and multi-user two-way ranging

A node in a wireless network includes a memory, transceiver, and processor operatively coupled to one another. The memory stores a signature of the node. The transceiver is configured to transmit, during an initial frame, the signature to one or more neighboring nodes, and receive, during the initial frame, a... Northwestern University

10/19/17 / #20170299811

X(2) modulators and related devices with barium titanate photonic crystal waveguides

Barium titanate thin film waveguides and related modulator and devices with photonic crystal structures to promote wide bandwidths, low operating voltages and small footprint.... Northwestern University

10/12/17 / #20170290944

Promotion of wound healing

The present invention provides compositions and methods that promote wound healing in a subject with a cutaneous injury. In particular, the present invention provides systemic and/or local administration of one or more compositions that cause ganglioside depletion (e.g., glucosylceramide synthase (GCS) inhibitors) for the treatment of cutaneous wounds.... Northwestern University

10/12/17 / #20170291817

Purification of carbon nanotubes via selective heating

The present invention provides methods for purifying a layer of carbon nanotubes comprising providing a precursor layer of substantially aligned carbon nanotubes supported by a substrate, wherein the precursor layer comprises a mixture of first carbon nanotubes and second carbon nanotubes; selectively heating the first carbon nanotubes; and separating the... Northwestern University

10/12/17 / #20170293009

Magnetic barcode imaging

Provided herein is technology relating to magnetic resonance imaging contrast agents and particularly, but not exclusively, to methods and systems for visualizing one or more magnetic resonance imaging contrast agent.... Northwestern University

10/05/17 / #20170281680

Scaffold delivery of immune suppressors and transplant material for control of transplant rejection

The present invention provides compositions, devices, and methods for the coordinated delivery of transplant material and immune suppressors for control of transplant rejection. In particular embodiments, immune suppression cells (e.g., regulatory T cells) and transplant material (e.g., cells, tissue, etc.) are provided within a delivery scaffold for transplant into a... Northwestern University

10/05/17 / #20170281798

Synthetic scaffolds for metastasis detection

Provided herein are synthetic scaffolds engineered to function as a pre-metastatic niche to detect metastasis. In particular, synthetic scaffolds described herein provide detection of the earliest events in metastasis, thereby enabling treatment of metastasis before the disease burden increases.... Northwestern University

10/05/17 / #20170283467

Programmable polypeptide and nucleic acid nanoparticles

Provided herein are polypeptides that self-assemble into nanoparticles upon binding to nucleic acids. The nanoparticles find use, for example in the delivery of the nucleic acids into cells.... Northwestern University

10/05/17 / #20170289707

Hearing assistance device control

A hearing assistance device may be a hearing aid worn on a person or a mobile device. The hearing assistance device may perform a hearing assistance algorithm based on signal processing parameters. A set of audiological values for a population may be identified. The set of audiological values has a... Northwestern University

09/28/17 / #20170275278

Mammalian and bacterial nitric oxide synthase inhibitors

Disclosed are compounds that are shown to inhibit the biological activity of nitric oxide synthases (NOSs). Also disclosed are pharmaceutical compositions comprising the compounds, and methods of using the compounds and pharmaceutical compositions for treating a subject in need thereof. Because the disclosed compounds are shown to inhibit the activity... Northwestern University

09/21/17 / #20170269172

Group iii-v ferromagnetic/non-magnetic semiconductor heterojunctions and magnetodiodes

Ferromagnetic Group III-V semiconductor/non-magnetic Group III-V semiconductor heterojunctions, with a magnetodiode device, to detect heterojunction magnetoresistance responsive to an applied magnetic field.... Northwestern University

09/21/17 / #20170269755

Haptic device with controlled traction forces

A haptic device comprising a substrate having a surface, a first actuator that modulates a friction experienced by a user's finger touching the substrate surface, a second actuator that oscillates the substrate surface laterally, such that the combined effect of the first and second actuator is a net shear force... Northwestern University








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