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Novo Nordisk A s
Novo Nordisk A s Novo Alle
Novo Nordisk A s Novo All xe9
Novo Nordisk A s A Corporation
Novo Nordisk A s_20100107
Novo Nordisk A s_20100114
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Novo Nordisk A s_20100128
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Novo Nordisk A s patents


Recent patent applications related to Novo Nordisk A s. Novo Nordisk A s is listed as an Agent/Assignee. Note: Novo Nordisk A s may have other listings under different names/spellings. We're not affiliated with Novo Nordisk A s, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "N" | Novo Nordisk A s-related inventors


Stable, protracted glp-1/glucagon receptor co-agonists for medical use

The invention relates to novel stable and protracted GLP-1/glucagon receptor co-agonists, to the use of said peptides in therapy, to methods of treatment comprising administration of said peptides to patients, and to the use of said peptides in the manufacture of medicaments.... Novo Nordisk A s

Accessory device with mounting safety feature

A medial assembly comprises a logging first unit adapted to be mounted on a drug delivery device second unit from a fully un-mounted to a fully mounted position along a path. The first unit comprises a switch operatable between an off- and an on-state when the first unit is mounted... Novo Nordisk A s

Acylated glucagon analogues

The present invention relates to novel peptide compounds which have an improved physical stability in solution and improved solubility at neutral pH, to the use of the compounds in therapy, to methods of treatment comprising administration of the compounds to patients in need thereof, and to the use of the... Novo Nordisk A s

Antibodies that bind peptidoglycan recognition protein 1

Disclosed herein is a method for identifying TREM-1's ligand and antibodies, or fragments thereof, which are capable of modifying the function of TREM-1's ligand. Antibodies that reduce or block TREM-1 activation may be identified and selected using this method. Antibodies that bind to TREM-1's ligand and reduce TREM-1 activity may... Novo Nordisk A s

Pharmaceutical composition for oral insulin administration comprising a tablet core and a polyvinyl alcohol coating

The present invention relates to a solid oral insulin composition comprising a salt of capric acid which enhances the bioavailability and/or the absorption of said acylated insulin in combination with a polyvinyl alcohol coating, which is soluble in aqueous media independent of pH.... Novo Nordisk A s

Tablets comprising glp-1 agonist and enteric coating

The present invention relates to solid pharmaceutical compositions for oral administration comprising a GLP-1 agonist, an absorption enhancer which is a salt of medium-chain fatty acid, and an enteric coating as well as uses thereof.... Novo Nordisk A s

Stable antibody containing compositions

The invention relates to stable and low viscous (<50 cP) protein containing compositions, in particular, but not exclusively stable antibody containing compositions and to the use of said stable proteins in therapy, in particular for the subcutaneous delivery of said stable protein.... Novo Nordisk A s

A piston rod drive for an injection device

The invention relates to a piston rod drive arrangement for an injection device used for self-administration of a plurality of individually set doses. The drive arrangement is made from a first element (10) mating the non-circular cross-section (3) of a piston rod (1) and a second element (20) having an... Novo Nordisk A s

An injection needle assembly for an injection device and an injection device comprising such assembly

An injection needle assembly (50) for an injection device, comprising: a) a needle cannula (3) attached to a needle hub (4) and defining a pointed tip at a free end (3a, 3b), and b) a needle cover (10, 10a, 10b) forming an axially extending elongated flexible enclosure accommodating the needle... Novo Nordisk A s

Efficient induction of definitive endoderm from pluripotent stem cells

The present invention relates to a method to differentiate pluripotent stem cells to a primitive streak cell population, in a stepwise manner for further maturation to definitive endoderm.... Novo Nordisk A s

N-glycosylation

The present invention relates to a mammalian cell comprising a gene encoding a polypeptide of interest, wherein the polypeptide of interest is expressed comprising one or more posttranslational modification patterns. These modifications are useful for example in glycoprotein production where the antibodies with the modifications have an enhanced antibody-dependent cell-mediated... Novo Nordisk A s

An injection needle assembly for an injection device and an injection device comprising such assembly

An injection needle assembly (50) for an injection device, comprising: a) a needle cannula (3) attached to a needle hub (4) and defining a pointed tip at a free end (3a, 3b), and b) a needle cover (10, 10a, 10b) forming an axially extending elongated flexible enclosure accommodating the needle... Novo Nordisk A s

Fgf21 derivatives and uses thereof

The invention relates to a derivative of a FGF21 protein having a cysteine residue at a position corresponding to position 167, 169, 170, 171, 172, 173, 174, 175 and in particular position 180 or position 181 of mature human FGF21 and derivatives thereof having a side chain attached to this... Novo Nordisk A s

Drug delivery device with a hydraulic trigger mechanism

A device for administering a fluid medicament by injection comprises a dosing portion (1) with a collapsible reservoir (10). The reservoir (10) has a maximum volume in an extended state and a minimum volume in a collapsed state. Prior to injection, the reservoir (10) is in the extended state and... Novo Nordisk A s

Handheld spring driven injection device with force regulation

A handheld injection device (10) comprising an needle cannula, a reservoir configured for containing a liquid drug to be dispensed, a piston, a trigger button (22), an elongated, hollow outer housing (20) in which the reservoir is positioned, the needle cannula being in liquid communication with the reservoir and extending... Novo Nordisk A s

Needle unit with a lockable needle shield and an injection device comprising such a needle unit

A needle unit (20) comprising: a needle hub (21) comprising a needle (23) and a needle shield (22), wherein the needle hub (21) and the needle shield (22) are arranged to form a needle unit (20) where the needle hub is arranged displaceably inside the needle shield such that the... Novo Nordisk A s

Kit comprising a medical accessory device and a dummy unit

The invention provides a kit comprising a medical accessory device and a dummy unit. The accessory device comprises first attachment means configured for releasable attachment of the accessory to co-operating second attachment means on an original device having an outer surface defining an original device space envelope. The dummy unit... Novo Nordisk A s

A multi-state ratchet mechanism for drug injection devices

The present invention relates in a first aspect to a multi-state ratchet mechanism for a drug injection device. The multi-state ratchet mechanism comprises a ratchet gear member and a cooperating ratchet pawl member. An annular inner surface of the ratchet gear member comprises a first ring shaped surface portion with... Novo Nordisk A s

Spring-driven drug delivery device

The present invention relates to a drug delivery device (100) comprising a housing (101), a threaded piston rod (102), a rotatable drive tube (103), a drive nut (104) in threaded engagement with the piston rod (102) and being rotationally locked but axially moveable relative to the drive tube (103), and... Novo Nordisk A s

Alpha-1-antitrypsin (a1at) fusion proteins and uses thereof

The invention relates to MIC-1 fusion proteins. More specifically it relates to compounds comprising fusion proteins comprising a MIC-1 protein or an analogue thereof at the C-terminus of the fusion protein and a functional variant of human A1AT (A1AT) at the N-terminus of the fusion protein connected via a peptide... Novo Nordisk A s

A wireless data communication module for drug injection devices

The present invention relates to a wireless data communication module (100) for a drug injection device. The wireless data communication module (100) comprises a folded flexible carrier member (107) comprising a plurality of stacked component support regions (203, 205, 207, 209, 211) and a display (103), such as a LCD... Novo Nordisk A s

Drug injection device with visual end-of-contents indicator system

Medical device (1) for injecting a set dose of an injectable product into a patient, the device having a cartridge containing the injectable product, a movable dosing driver (11) and a movable dose setting driver (15), and an end-of-contents indicator system (13) having counting means (17) with a counting part... Novo Nordisk A s

Needle assembly with needle hub shielding a needle cannula

A needle assembly (1) comprising a needle unit (2), where the needle unit (2) comprises a hub (6) with a skirt (3) having a longitudinal central axis (A), where the skirt (3) is having a proximal (7) and a distal end (8). The skirt is also having an internal surface... Novo Nordisk A s

Dosing regimen

The present invention relates to a long acting insulin analogue for use in reducing the risk of hypoglycaemia in a patient suffering from diabetes and requiring high amounts of delivered insulin, wherein the long acting insulin analogue is administered to said patient and in an amount of greater than 80... Novo Nordisk A s

Drug delivery device with air-in-cartridge safety feature

A drug delivery device adapted to receive a drug-filled cartridge (10), comprising dose setting means allowing a user to set a desired dose of drug to be expelled, an electronic controller (70,270) adapted to control a motor (51) to move a drive member to thereby expel an amount of drug... Novo Nordisk A s

Glp-1 derivatives and uses thereof

The invention relates to a derivative of a GLP-1 analogue of a general Formula I, which derivative comprises a side chain attached to a Lys residue at position 34, 35, 36, 37, or 38 of the GLP-1 analogue, which side chain comprises a Branched linker, a 1st and a 2nd... Novo Nordisk A s

Receptor trem (triggering receptor expressed on myeloid cells) and uses thereof

Novel activating receptors of the Ig super-family expressed on human myeloid cells, called TREM(s) (triggering receptor expressed on myeloid cells) are provided. Specifically, two (2) members of TREMs, TREM-1 and TREM-2 are disclosed. TREM-1 is a transmembrane glycoprotein expressed selectively on blood neutrophils and a subset of monocytes but not... Novo Nordisk A s

Oral dosing of glp-1 compounds

The present invention relates to improved uses of GLP-1 peptides in oral therapy.... Novo Nordisk A s

A manufacturing one of a range of autoinjectors

A method of manufacturing one of a range of autoinjectors having cartridges (600, 600′, 600″) with different preset fill volumes, the method comprising the steps of: a) providing a front body assembly (100b, 100c, 100c′, 100c″), b) providing a cartridge (600, 600′, 600″) of given fill volume, c) providing a... Novo Nordisk A s

Selective pyy compounds and uses thereof

The invention relates to PYY compounds with the amino acid modifications 7Lys, 30Trp, and 31Leu, and in addition to these, 22Ile and/or 28Tyr, and derivatives thereof. The compounds of the invention are selective Y2 receptor agonists. The invention also relates to pharmaceutical compositions comprising such PYY compounds and pharmaceutically acceptable... Novo Nordisk A s

Antagonistic dr3 ligands

The present invention relates to treatment of inflammatory diseases. In particular, the present invention relates to antagonistic DR3 ligands useful for treating inflammatory diseases.... Novo Nordisk A s

Torsion spring for an injection device and an injection device comprising such torsion spring

The present invention relates to a helically coiled torsion spring for a torsion spring based automatic injection device, coiled in a longitudinal direction (X) and having a number of consecutive windings located between a distal winding having a distal end and a proximal winding having a proximal end. Each winding... Novo Nordisk A s

Site directed mutagenesis of trem-1 antibodies for decreasing viscosity

Antibodies that are capable of specifically binding and preventing the activation of TREM-1, a protein expressed on monocytes, macrophages and neutrophils with both good affinity and low viscosity at clinically relevant concentrations are described. Such antibodies find utility in the treatment of individuals with an inflammatory disease, such as rheumatoid... Novo Nordisk A s

Drug delivery device with piston driver distal feature

Drug delivery device adapted to receive a cartridge, comprising drug expelling means with a piston driver comprising a distal end adapted to abut and axially move the piston of a loaded cartridge to thereby expel an amount of drug from the cartridge, and a motor assembly for moving the piston... Novo Nordisk A s

An injection device adapted to detect air in a cartridge

A drug delivery device (100) for estimating the amount of free air in a cartridge (1) comprising a cartridge receiving portion (not shown) adapted to receive a cartridge (1), the cartridge (1) comprising a body portion (6), an axially displaceable piston (5), and a distal outlet portion (4), an expelling... Novo Nordisk A s

10/12/17 / #20170292859

Rotary sensor component and manufacture

A method of manufacturing a sensor member comprising the steps of arranging an initial sensor member in a fixed position relative to a material-removing tool, and control the tool to (i) remove material from the carrier alignment portion to thereby create an alignment structure, and (ii) remove material from at... Novo Nordisk A s

10/05/17 / #20170281785

Glycerol linked pegylated sugars and glycopeptides

The present invention provides conjugates between peptides and PEG moieties through glycerol linkers.... Novo Nordisk A s

10/05/17 / #20170281809

Anti-nkg2a antibodies and uses thereof

Described herein are anti-NKG2A antibodies suitable for human therapy, including humanized versions of murine anti-NKG2A antibody Z270, as well as related methods and materials for producing and using such antibodies. Exemplary complementarity-determining regions (CDRs) sequences and sites for optional amino acid back-substitutions in framework region (FR) and/or CDRs of such... Novo Nordisk A s

09/28/17 / #20170274148

Drug delivery device with combined setting and release member

Drug delivery device has drive assembly adapted to move a piston rod in a distal direction, the drive assembly comprising a drive spring. A rotatable setting member allows a user to set a dose amount to be expelled, the drive spring being strained during dose setting. User actuated release means... Novo Nordisk A s

09/21/17 / #20170266389

Accessory device with snap feature

A logging device adapted to be attached to a pen drug delivery device (210) and capture a property value related to the dose amount of drug expelled from the drug delivery device during an expelling event, the logging device comprising a bore in which a snap lock with a flexible... Novo Nordisk A s

09/14/17 / #20170258711

Fatty acid acylated d-amino acids for oral peptide delivery

The present invention relates to fatty acid acylated amino acids (FA-Daa's) acting as permeation enhancers for oral delivery of therapeutic macromolecules such as peptides and pharmaceutical compositions comprising such FA-Daa's.... Novo Nordisk A s

09/14/17 / #20170258999

Drug delivery device with cartridge centring feature

Drug delivery device adapted to receive a cartridge, comprising a piston driver adapted to expel an amount of drug from a received cartridge, and a base member adapted to engage a cartridge and position the cartridge relative to the piston driver, the base member comprising a main portion with a... Novo Nordisk A s

09/14/17 / #20170259005

Injection device with torsion spring and rotatable display

The present invention relates to an injection device comprising a torsion spring operatively connected to a dose setting member being adapted to set a dose to be ejected from the injection device. A rotatably mounted display member adapted to display the dose to be ejected in accordance with a setting... Novo Nordisk A s

09/14/17 / #20170259010

Drive mechanism for an injection device

The invention relates to an injection device for self-administration of doses of a liquid drug. The injection device carries a needle cannula (15) which is concealed by a telescopically movable shield (20). Further a stopping means (30) interconnects the shield with the helical rotatable scale sleeve (25) such that the... Novo Nordisk A s

09/14/17 / #20170259011

Torsion spring driven injection device

The present invention relates to a torsion spring driven injection device for delivering set doses of a liquid drug. The injection device mechanism is encapsulated in a housing which also stores the cartridge containing the liquid drug. A needle cannula which is in liquid communication with the interior of the... Novo Nordisk A s

09/14/17 / #20170260289

Antibodies capable of binding two epitopes on tissue factor pathway inhibitor (1-161)

The application discloses bispecific TFPI antibodies that are capable of specifically and simultaneously binding two epitopes within TFPI (1-161). Such bispecific antibodies strongly enhance thrombin generation by neutralising TFPI, even where the concentration of TFPI is elevated. Bispecific antibodies of the invention or compositions comprising them may be used for... Novo Nordisk A s

09/07/17 / #20170252408

Liraglutide in cardiovascular conditions

The present invention relates to the GLP-1 receptor agonist liraglutide for use in medicine.... Novo Nordisk A s

08/17/17 / #20170232203

Pen-type drug injector and add-on module with magnetic dosage sensor system and error detection

Add-on module (100) for logging the value of an expelled dose from a pen-type drug injector (200), comprising a magnetic sensor system comprising first and second sensor means (745/746) as well as a mechanical dose setting and expelling mechanism comprising a magnetic clutch element (240/740) which rotates during drug expelling.... Novo Nordisk A s

08/10/17 / #20170224924

A stop mechanism for a hypocycloid end-of-content mechanism in an injection device

The invention relates to a stop mechanism for a non-axial working End-of-Content mechanism which is geared by a hypocycloid gearing. The EoC mechanism comprises a stationary first element (10), an EoC element (30) and a rotational element (50) with a cam surface. The EoC element rotates around a center axis... Novo Nordisk A s

08/10/17 / #20170224927

Pen-type drug delivery device with electronic display on clip member

A portable pen-type drug injection device (300) comprises a main portion (301) and a clip (360). The clip comprises a base portion mounted to a portion of the drug delivery device, and a clip gripping portion with a free end. The device further comprises drug expelling means having dose setting... Novo Nordisk A s

07/27/17 / #20170209650

Logging device operated by drug delivery device

An add-on dose logging device for a pen device consumes energy when the sensors are operated and when the display is active. By using cap-off event to activate the sensor system only, and using cap-on event to de-activate the sensor system and activate the display for a given time to... Novo Nordisk A s

07/06/17 / #20170189616

System for optimizing a drug dosage regimen over time

A system for optimizing a patient's basal insulin dosage regimen over time, adapted to determine from blood glucose values whether and by how much to vary a patient's present recommended amount of the insulin-containing drug in order to maintain the patient's future blood glucose level measurements within a predefined range,... Novo Nordisk A s

07/06/17 / #20170190757

Novel glucagon analogues

The present invention relates to novel peptide compounds which have a protracted profile of action and improved solubility and stability, to the use of the compounds in therapy, to methods of treatment comprising administration of the compounds to patients in need thereof, and to the use of the compounds in... Novo Nordisk A s

07/06/17 / #20170190775

Antibodies that bind and block triggering receptor expressed on myeloid cells-1 (trem-1)

The invention relates to antibodies that are capable of specifically binding TREM-1 and preventing the activation of TREM-1, a protein expressed on monocytes, macrophages and neutrophils. Such antibodies find utility in the treatment of individuals with an inflammatory disease, such as rheumatoid arthritis and inflammatory bowel disease.... Novo Nordisk A s

06/29/17 / #20170182124

Fgf21 derivatives and uses thereof

The invention relates to a derivative of a FGF21 protein having a cysteine residue at a position corresponding to position 167, 169, 170, 171, 172, 173, 174, 175 and in particular position 180 or position 181 of mature human FGF21 and derivatives thereof having a side chain attached to this... Novo Nordisk A s

06/29/17 / #20170182256

Logging device for drug delivery device

An add-on logging device (100, 300) mounted to a drug delivery device is turned on when the cap is removed. After a given amount of time in inactivity the sensor means of the add-on device is turned off automatically to save energy. If the user takes a dose of drug... Novo Nordisk A s

06/22/17 / #20170173268

Nut assembly for a medical device

The present invention provides a medical device (200) comprising a housing (201, 202), a guide structure (205) arranged stationarily with respect to the housing (201, 202) and ex-tending along a longitudinal axis, the guide structure (205) comprising a helical track (287) and a longitudinal track (289) being connected with the... Novo Nordisk A s

06/22/17 / #20170175859

Telescopic drive arrangement with oldham coupling

Telescopic drive assembly comprising a rotatable threaded drive member, an outer tube assembly arranged axially moveable relative to the drive member but non-rotational relative to a frame and comprising a nut portion in threaded engagement with the drive member, a transmitter tube with an outer thread, and a drive tube... Novo Nordisk A s

06/15/17 / #20170165327

Process for the preparation of insulin-zinc complexes

The invention concerns a process for preparing a pharmaceutical formulation comprising an insulin derivative, wherein the process comprises dissolving an insulin derivative in water, adjusting the pH of the solution to a pH above 7.2, adding a zinc solution while stirring continuously and adjusting the pH to the target pH... Novo Nordisk A s

06/15/17 / #20170165431

Automatic injection device with a top release mechanism

The present invention relates to a handheld mechanical injection device by which set doses of a liquid medicament can be injected from a medical reservoir. The medicament is expelled through an injection needle by release of a power reservoir in the device, the power reservoir being fully or partially released... Novo Nordisk A s

06/08/17 / #20170157340

Drug delivery device with indicator guidance

A drug delivery device comprising drug expelling means for expelling an amount of drug, a number of user-oriented structures, and individual visual communication means arranged in the vicinity of at least two user-oriented structures. The device further comprises control means adapted to detect an error condition associated with each of... Novo Nordisk A s

06/01/17 / #20170151388

Motorized drug delivery device

A drug delivery device comprising a piston rod adapted to engage and axially move a cartridge piston to thereby expel an amount of drug from a loaded cartridge corresponding to a set dose amount, the device comprising a motor for moving the drive member from an initial position, through a... Novo Nordisk A s

05/25/17 / #20170143902

Autoinjector having needle shield triggering

An autoinjector (100) for expelling a dose of a drug from a held cartridge (600) is described. A needle shield (350, 380) is axially movable relative to a base (200, 220) between an extended position and a collapsed position to operate a trigger lock (328, 388) configured for releasably maintaining... Novo Nordisk A s

05/25/17 / #20170143909

Telescopic drive arrangement for drug delivery device

Drug delivery device adapted to receive a cartridge, comprising a drive tube with an inner thread, a motor assembly comprising a drive shaft and being adapted to be received inside the drive tube, a drive member attached to the drive shaft and with an outer thread in engagement with the... Novo Nordisk A s

05/25/17 / #20170145059

Novel amylin and calcitonin receptor agonist

The present invention relates to peptides comprising an amino acid sequence SEQ ID NO: 1 (EASELSTAALGRLSAELHELATLPRTETGPESP), analogues and derivatives thereof and pharmaceutical compositions comprising such peptides and derivatives. This invention further regards the use of these peptides according to SEQ ID NO: 1, analogues and derivatives thereof as medicaments.... Novo Nordisk A s

Patent Packs
05/25/17 / #20170145069

Glp-1 derivatives

The invention relates to a derivative of a GLP-1 peptide, which peptide has two Lys residues, namely a first and a second Lys residue, and a maximum of eight amino acid changes as compared to GLP-1(7-37) (SEQ ID NO: 3), which derivative comprises two protracting moieties attached to the epsilon... Novo Nordisk A s

05/18/17 / #20170136104

Glycopegylated factor ix

Conjugates between Factor IX and PEG moieties. are disclosed in the present application. The conjugates are linked via a glycosyl linking group interposed between and covalently attached to the peptide and the modifying group. Conjugates are formed from glycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a... Novo Nordisk A s

05/18/17 / #20170136173

Pen-type drug injection device having multiple-use needle module with needle cleaning reservoir

Disclosed is a medical injection device (1) comprising a needle assembly (20) having a cannula (21) and a telescopic shield (30) for covering the distal tip (23) in a no use situation. The telescopic shield further carries a cleaning reservoir (40) for cleaning the needle cannula between two subsequent injections.... Novo Nordisk A s

05/18/17 / #20170136192

Injection device having needle shield locking

An injection device for expelling a dose of drug from a held cartridge (600) is described. A needle shield (350, 380) is axially movable relative to a base (200, 220, 230) between a proximal collapsed position and a distal extended position. A needle shield lock comprises a deflectable lock element... Novo Nordisk A s

05/04/17 / #20170119973

A pen-shaped torsion spring driven injection device

The invention relates to a pen-shaped torsion spring driven injection device for apportioning set dose of a liquid drug. A piston rod having an external thread is driven forward by a rotatable piston rod guide engaging the piston rod. The piston rod guide is rotated by a torsion spring encompassed... Novo Nordisk A s

04/27/17 / #20170114116

Double-acylated glp-1 compounds

The invention relates to a derivative of a GLP-1 peptide, which peptide comprises a first Lys residue at a position corresponding to position 36 of GLP-1(7-37) (SEQ ID NO:1), a second Lys residue at a position corresponding to position 37 of GLP-1(7-37) (SEQ ID NO: 1), and a maximum of... Novo Nordisk A s

04/27/17 / #20170114147

Antibodies against tissue factor pathway inhibitor

The invention relates to antibodies that specifically bind to tissue factor pathway inhibitor (TFPI) and that reduce the clotting time of blood. Such antibodies have utility in the treatment of subjects with a coagulopathy.... Novo Nordisk A s

04/20/17 / #20170106135

A needle arrangement

The present invention relates to a needle arrangement for an injection device. The needle arrangement is made up from needle cannula which is mounted such that a distal part having a distal tip extends in a distal direction. Further, a telescopically movable shield carrying a cleaning chamber surrounds at least... Novo Nordisk A s

04/13/17 / #20170101454

Glp-1/glucagon receptor co-agonists for medical use

The present invention relates to novel glucagon derivatives which are GLP-1/glucagon receptor co-agonists, and to the use of said glucagon derivatives in medicine, such as in the treatment of diabetes, obesity and related diseases and conditions.... Novo Nordisk A s

04/06/17 / #20170096450

Dipeptide comprising a non-proteogenic amino acid

Described is a dipeptide comprising a non-proteogenic amino acid, methods of making such and methods of using said dipeptide in a process of making a polypeptide or protein comprising one or more non-proteogenic amino acids.... Novo Nordisk A s

03/30/17 / #20170087306

Injection device having automatic needle retraction

The present invention relates to an injection device for delivering set doses of a liquid drug to a user. The injection device has a scale drum for displaying the set dose, which scale drum is helically guided in a housing. The scale drum is thus rotational in relation to the... Novo Nordisk A s

03/23/17 / #20170080165

Drug delivery device with cap induced needle movement

A drug delivery device (1, 200) comprising a drug delivery unit (10, 210) comprising a housing (12, 212) extending along a general axis, a variable volume reservoir (40′, 40, 140, 240), and a needle support (50′, 50, 150, 250) for receiving a needle assembly (30′, 30, 130, 230), the needle... Novo Nordisk A s

03/16/17 / #20170073417

Selective elimination of erosive cells

The current invention relates to the treatment of diseases characterized by cartilage destruction and/or bone erosion. In particular the present invention relates to the treatment of osteoarthritis, osteoporosis, psoriatic arthritis or rheumatic arthritis with an anti-NKG2A antibody.... Novo Nordisk A s

03/16/17 / #20170073421

Therapeutic antibodies

The present invention concerns human antibodies recognising the human C5a receptor. By binding to C5aR the antibodies inhibit C5a signalling, whereby the pro-inflammatory signal is inhibited. Based on the role of C5a and its receptor in stimulation of inflammation the invention further relates to therapeutic use of said human anti-C5aR... Novo Nordisk A s

03/09/17 / #20170066813

Factor viii variants having a decreased cellular uptake

The present invention relates to modified coagulation factors. In particular, the present invention relates to modied Factor VIII molecules having decreased cellular uptake.... Novo Nordisk A s

Patent Packs
03/02/17 / #20170058014

Double-acylated glp-1 derivatives

The invention relates to a derivative of a GLP-1 analogue, which analogue comprises a first K residue at a position corresponding to position 27 of GLP-1(7-37) (SEQ ID NO: 1); a second K residue at a position corresponding to position T of GLP-1(7-37), where T is an integer in the... Novo Nordisk A s

03/02/17 / #20170058308

Integrated continuous biomanufacturing process

The invention is a process and apparatus thereto for the end-to-end and continuous production of a purified protein, the process comprising the use of an integrated apparatus comprising a first and second processing unit having continuous and matched outflow and inflow, thereby providing for a means of integration of a... Novo Nordisk A s

02/23/17 / #20170051034

Novel glucagon analogues

The present invention relates to novel peptide compounds which have a protracted profile of action and improved solubility and stability, to the use of the compounds in therapy, to methods of treatment comprising administration of the compounds to patients in need thereof, and to the use of the compounds in... Novo Nordisk A s

02/16/17 / #20170043014

Treatment of diabetes type 1 using glp-1 and anti-il-21

The present invention relates to use of a GLP-1 agonist and an anti-IL-2 antibody in treatment and/or prevention of type 1 diabetes.... Novo Nordisk A s

02/16/17 / #20170044210

Methods for the purification of proteins using caprylic acid

A protein purification process with virus inactivation or removal uses caprylic acid (octanoic acid) at acidic pH. The method comprises caprylic acid treatment as part of the chromatographic step so as to perform viral inactivation without a discontinuous process and without the requirement of attention by personnel, particularly when the... Novo Nordisk A s

01/26/17 / #20170020992

Factor viii molecules with reduced vwf binding

The present invention relates to a recombinant Factor VIII molecule, wherein said molecule has reduced vWF binding capacity, and wherein said molecule is covalently conjugated with at least one side group.... Novo Nordisk A s

01/19/17 / #20170014575

Autoinjector having needle shield triggering

An autoinjector (100) for expelling a single dose of drug from a held cartridge (600) comprising a piston (630), the autoinjector comprising: a) a base (200, 220), b) a needle (500) that is fixedly mounted relative to the base (200, 220), c) a plunger (310, 320, 400) adapted for cooperation... Novo Nordisk A s

01/19/17 / #20170015729

Factor viii fusion protein

The present invention relates to modified coagulation factors. In particular, the present invention relates to conjugated Factor VIII molecules fused to a polypeptide such as e.g. an antibody binding protein or a Fc domain.... Novo Nordisk A s

01/12/17 / #20170007707

Derivatives of glp-1 like peptides, and uses thereof

The invention relates to derivatives of GLP-1 like peptides which are C-terminally extended analogues of native GLP-1. The derivatives comprise two side chains, one at a position corresponding to position 42, and one at a position corresponding to position 18, 23, 27, 31, 36, or 38, wherein both positions are... Novo Nordisk A s

01/12/17 / #20170007712

Glycopegylation methods and proteins/peptides produced by the methods

The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.... Novo Nordisk A s

01/12/17 / #20170007774

Telescopic drive arrangement

Telescopic drive assembly comprising a rotatable threaded drive member, an outer tube assembly arranged axially moveable relative to the drive member but non-rotational relative to a frame and comprising a nut member in threaded engagement with the drive member, a transmitter tube with an outer thread, and a drive tube... Novo Nordisk A s

01/12/17 / #20170007775

A cartridge and needle assembly in combination

The present invention relates to a combined cartridge and needle assembly (10, 15) for use in a re-useable injection device The cartridge (10) containing a pharmaceutical liquid drug and the needle assembly (15) with a needle cannula (25) is permanently attached to each other to form one single unit mountable... Novo Nordisk A s

01/12/17 / #20170008928

Novel peptides and peptide derivatives and uses thereof

The invention relates to cholecystokinin (CCK) derivatives of the general formula I: P-L-X1-X2-X3-Gly-Trp-X6-DMeAsp-X8-NH2, wherein P is Chem. 1: HOOC—(CH2)x—CO—*, wherein x is an integer in the range of 12-18; L is absent, or L comprises at least one linker element selected from Chem. 2: *—NH—CH(COOH)—(CH2)2—CO—*, Chem. 3: *—NH—(CH2)2—[O—(CH2)2]k—O—[CH2]n—CO—* wherein k... Novo Nordisk A s

01/12/17 / #20170008943

Stable glucagon analogues and use for treatment of hypoglycaemia

The invention relates to derivatives of glucagon analogues comprising the substitutions Imp1 and His3, a substituent having three to ten negatively charged moieties covalently attached to a side chain of a lysine as well as intermediates and compositions thereof and their use in medicine.... Novo Nordisk A s

01/12/17 / #20170008945

Novel insulin derivatives and the medical uses hereof

The present invention is in the therapeutic fields of drugs for medical conditions relating to diabetes. More specifically the invention relates to novel acylated derivatives of human insulin analogues. The invention also provides pharmaceutical compositions comprising such insulin derivatives, and relates to the use of such derivatives for the treatment... Novo Nordisk A s

01/05/17 / #20170000953

A housing for a medical injection device

The invention relates to a medical injection device having polymeric housing. The housing comprises a moulded outer housing element and a moulded ring-shaped unitary element. The ring-shaped unitary element carries a pointer and a thread segment in predetermined and correlated positions. The pointer points to indicia on a scale drum... Novo Nordisk A s








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