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Ohio State Innovation Foundation patents


Recent patent applications related to Ohio State Innovation Foundation. Ohio State Innovation Foundation is listed as an Agent/Assignee. Note: Ohio State Innovation Foundation may have other listings under different names/spellings. We're not affiliated with Ohio State Innovation Foundation, we're just tracking patents.

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Method of generating an adaptive partial report and implementing the same

The invention provides a method of generating an adaptive partial report for an observer with an apparatus comprising a display, a user interface, and a processor. The apparatus can be a computer system or an electronic device, for example. The method includes the processor characterizing an iconic memory decay function... Ohio State Innovation Foundation

Methods to improve induction of iga antibodies by vaccines

A vaccine composition is disclosed that contains a vaccine antigen and a neutrophil inhibitor in amounts effective to promote an IgA response to the antigen in a subject. Also disclosed is a method for enhancing immune response to a vaccine antigen in a subject that involves co-administering to the subject... Ohio State Innovation Foundation

Hierarchically porous aluminosilicate materials

Disclosed are methods of synthesizing a hierarchically porous aluminosilicate materials. Methods for synthesizing a hierarchically porous aluminosilicate material can comprise (i) combining, in aqueous solution, a base, an aluminum source, and silicon source to form a precursor gel; (ii) removing water from the precursor gel to form a nucleated gel;... Ohio State Innovation Foundation

Engineered calmodulin for treatment of ryanopathies

Compositions and methods are disclosed for altering the binding affinity of calmodulin for ryanodine receptor 2 (RyR2). As disclosed herein, these therapeutic calmodulin (TCaM) proteins can be used to correct ryanopathies by prolonging the RyR2 refractory period. Therefore, also disclosed is a method for treating a ryanopathy-associated disease in a... Ohio State Innovation Foundation

Miniaturized gas sensor device and method

Various embodiments of a gas sensor device and method of fabricating a gas sensor device are provided. In one embodiment a gas sensor device includes a base substrate, an electrolyte layer disposed on the base substrate and a plurality of potentiometric sensor units electrically coupled to the base substrate. Each... Ohio State Innovation Foundation

Miniaturized gas sensor device and method

Various embodiments of a gas sensor device and method of fabricating a gas sensor device are provided. In one embodiment a gas sensor device includes a base substrate, an electrolyte layer disposed on the base substrate and a plurality of potentiometric sensor units electrically coupled to the base substrate. Each... Ohio State Innovation Foundation

Miniaturized gas sensor device and method

Various embodiments of a gas sensor device and method of fabricating a gas sensor device are provided. In one embodiment a gas sensor device includes a base substrate, an electrolyte layer disposed on the base substrate and a plurality of potentiometric sensor units electrically coupled to the base substrate. Each... Ohio State Innovation Foundation

Method and system for multi-stage compression of a gas using a liquid

A method of compressing a gas includes pumping, using a pump, at least a portion of a liquid contained in a first chamber to a second chamber containing a gas at a first pressure such that the portion of the liquid pumped into the second chamber compresses the gas in... Ohio State Innovation Foundation

Frequency-independent receiver and beamforming technique

Example systems and methods described herein relate to radio communication architectures and techniques for beamforming and down-conversion without a priori knowledge of the source location or frequency. An example radio receiver includes a plurality of antenna elements that include a first element, a second element, and a third element. The... Ohio State Innovation Foundation

Displacement current phase tomography for imaging of lossy medium

A system and method for Displacement Current Phase Tomography. The present system invention obtains a linear relationship between mutual displacement current from a sensor (output current of the measuring electrode terminals) and the area (or volume) of an object to be imaged in the imaging domain. The system uses capacitance... Ohio State Innovation Foundation

Ultraviolet light emitting diodes with tunnel junction

An example ultraviolet (UV) light emitting diode (LED) is described herein. The UV LED can include an n-doped contact region, an active region configured to emit UV light that is arranged between an n-doped region and a p-doped region, and a tunnel junction. The tunnel junction is arranged between the... Ohio State Innovation Foundation

Systems and methods for partial or complete oxidation of fuels

A system used for converting multiple fuel feedstocks may include three reactors. The reactor system combination can be so chosen that one of the reactors completely or partially converts the fuel while the other generates the gaseous product required by utilizing the gaseous product from the second reactor. The metal-oxide... Ohio State Innovation Foundation

Live attenuated vaccines for pneumoviruses and related methods and materials

Described herein are mutant pneumoviruses comprising a nucleotide sequence which encodes a mutated zinc binding motif in an M2-1 protein of the pneumovirus, wherein the zinc binding motif is mutated relative to wild-type pneumovirus. The mutant pneumoviruses described herein grow to high titer in cell culture, are genetically stable, are... Ohio State Innovation Foundation

Materials and methods for the electrochemical reduction of carbon dioxide

Disclosed are methods for electrochemically reducing carbon dioxide to provide a product. The methods can comprise contacting the carbon dioxide with an electroreduction catalyst in an electrochemical cell, and applying a potential to the electrochemical ceil to form the product. The electroreduction catalyst can comprise a nanoporous Cu catalyst, a... Ohio State Innovation Foundation

Oligonucleotide lipid nanoparticle compositions, methods of making and methods of using the same

Methods for inhibiting oligonucleotide activity in vitro or in vivo to a cell that are formulated with at least one oligonucleotide encapsulated in a lipid nanoparticle are disclosed.... Ohio State Innovation Foundation

Method for autonomously parking and un-parking a motor vehicle

A method for autonomously parking or un-parking a motor vehicle includes the steps of locating the motor vehicle within a parking area, setting a destination location within the parking area, generating and setting a path from the location of the motor vehicle to the destination location, and autonomously driving the... Ohio State Innovation Foundation

Optimized path planner for an autonomous valet parking system for a motor vehicle

A method for autonomously parking or un-parking a motor vehicle includes locating the motor vehicle relative to a parking area, selecting a destination location within the parking area, generating a path from the location of the motor vehicle to the destination location, wherein the path includes a plurality of linked... Ohio State Innovation Foundation

Method for autonomously parking a motor vehicle for head-in, tail-in, and parallel parking spots

A method for autonomously parking a motor vehicle in various types of parking spots includes the steps of receiving a map of a parking area, locating the motor vehicle within the parking area, selecting a parking spot within the parking area, generating a node tree from the location of the... Ohio State Innovation Foundation

Method for controlling autonomous valet system pathing for a motor vehicle

A method for autonomously parking or un-parking a motor vehicle includes receiving a map of a parking area having a first temporary obstruction zone, determining a starting location of the motor vehicle relative to the parking area, selecting a destination location within the parking area, setting the first temporary obstruction... Ohio State Innovation Foundation

Methods and devices for optimizing magnetic resonance imaging protocols

Techniques for optimizing a magnetic resonance imaging (MRI) protocols are described herein. An example method can include receiving one or more MRI scanner settings for an imaging sequence; selecting at least one objective function from a plurality of objective functions; selecting an acquisition train length; selecting a k-space strategy; selecting... Ohio State Innovation Foundation

Systems and methods for additive manufacturing

Disclosed herein are systems and methods method of additively manufacturing distributed sensors in a structural workpiece. The apparatus includes a movable head having an actuator coupled to an ejection port to regulate dispensation of a first thermoplastic polymer fed from an elongated chamber located in the movable head and coupled... Ohio State Innovation Foundation

Methods and compositions related to single chain antibody fragments that bind to tumor-associated glycoprotein 72 (tag-72)

Disclosed herein are methods and compositions related to single chain antibody fragments which specifically bind sialyl-Tn epitope of tumor-associated glycoprotein 72 (TAG-72).... Ohio State Innovation Foundation

Galvanotaxis assay for quantitative assessment of metastatic potential of cancer cells

A system for accelerating and/or inhibiting the migration of cells by applying a time-varying magnetic field to induce eddy currents that promote electrotaxis (galvanotaxis) of cells without the need for chemokines or glucose. The present invention can also be used to study and quantify the metastatic potential of different cell... Ohio State Innovation Foundation

Chlamydia-activated b cell platforms and methods thereof

Disclosed herein is a Chlamydia-activated B cell (CAB) platform. Also disclosed is a method of enhancing a population of B cells, comprising exposing said B cells to Chlamydia spp. under conditions suitable to enhance the population of B cells, such that expansion and differentiation of said B cells takes place,... Ohio State Innovation Foundation

Chemical synthesis and screening of bicyclic peptide libraries

Disclosed herein are bicyclic peptide compounds, compositions comprising same, methods for making same, and libraries comprising same. The disclosed compounds, in various aspects, are useful for treating a variety of disorders, including inflammatory disorders, autoimmune disorders, and disorders of uncontrolled cellular proliferation. This abstract is intended as a scanning tool... Ohio State Innovation Foundation

Non-ionic, low osmolar contrast agents for delivery of antisense oligonucleotides and treatment of disease

Disclosed are compositions comprising an antisense oligonucleotide and a non-ionic, low-osmolar contrast agent. Also disclosed are methods of delivering an antisense oligonucleotide to a target site comprising incorporating the antisense oligonucleotide into a composition comprising a non-ionic, low-osmolar contrast agent. Also disclosed are methods of treating a neurodegenerative disease comprising... Ohio State Innovation Foundation

On-chip optical polarization controller

An example optical polarization controller can include a substantially planar substrate and a waveguide unit cell formed on the substantially planar substrate. The waveguide unit cell can include a first out-of-plane waveguide portion and a second out-of-plane waveguide portion coupled to the first out-of-plane waveguide portion. Each of the first... Ohio State Innovation Foundation

Lipid nanoparticle compositions and methods of making and methods of using the same

Lipid nanoparticle formulations, methods of making, and methods of using same are disclosed.... Ohio State Innovation Foundation

Mirna-based predictive models for diagnosis and prognosis of prostate cancer

The lack of clear predictors of prostate cancer progression leads to subjective decision-making regarding courses of treatment. The identification of new biomarkers that are predictive of recurrence after radical prostatectomy would advance the field of prostate cancer treatment. Disclosed are miRNAs that can be used as molecular biomarkers to detect... Ohio State Innovation Foundation

Functional surfaces and methods of making thereof

Provided herein are methods of making functional surfaces, including liquid repellant surfaces that can exhibit selective wetting properties. Methods of forming a functional surfaces can comprise providing a dispersion of nanoparticles; and applying the dispersion to a polymer surface to form a multiplicity of re-entrant structures embedded within and protruding... Ohio State Innovation Foundation

Oxygen carrying materials

In accordance with one embodiment of the present disclosure, an oxygen carrying material may include a primary active mass, a primary support material, and a secondary support material. The oxygen carrying material may include about 20% to about 70% by weight of the primary active mass, the primary active mass... Ohio State Innovation Foundation

Methods and devices for the preparation of nanomaterials

Disclosed herein are methods for preparing nanomaterials, such as nanoparticles. The methods can involve jet-mixing two or more precursor solutions to form the nanomaterials. By rapidly mixing the precursor solutions, nanomaterials of improved quality and uniformity can be prepared in high yield (e.g., in yields of at least 85%). The... Ohio State Innovation Foundation

Compositions and methods related to viral vaccines

Provided herein are methods and compositions relating to Infectious Bursal Disease Virus (IBDV), and vaccines for treatment and prevention thereof.... Ohio State Innovation Foundation

Patterned ion-sliced crystal for hybrid integrated photonics

An example method of forming a deterministic thin film from a crystal substrate is described herein. The method can include implanting ions into a surface of the crystal substrate to form a thin film crystal layer, and bonding the crystal substrate and a handle substrate to form a bilayer bonding... Ohio State Innovation Foundation

Materials and methods useful for treating glioblastoma

The present invention provides compositions and methods useful for treating cancers such as glioblastoma. SapC-DOPS was found to be synergistically effective at inducing cell death when administered in conjunction with rampamycin. SapC-DOPS/rapamycin combination therapy allows physicians to give lower doses of each drug and achieve better therapeutic efficacy. The compositions... Ohio State Innovation Foundation

11/30/17 / #20170341017

Membranes for fluid separation

Membranes, methods of making the membranes, and methods of using the membranes are described herein. The membranes can comprise a gas permeable support and a continuous phase comprising a selective inorganic material disposed within the gas permeable support. In some embodiments, the membranes can exhibit a CO2:N2 selectivity of at... Ohio State Innovation Foundation

11/23/17 / #20170332937

Hydraulically-powered and hybrid hydraulic-pneumatic achieving magnetic resonance elastography

Systems and methods are described for inducing tissue vibration for magnetic resonance elastography is described. The system includes a hydraulic drive component that is mechanically linked to a pneumatic drive component. The pneumatic drive component is pneumatically linked to a passive pneumatic actuator component that is positionable on a patient... Ohio State Innovation Foundation

11/23/17 / #20170332938

Methods for co-imaging tissue stiffness and blood flow in an mri scan

Techniques for co-imaging tissue stiffness and blood flow using a single MRI scan are disclosed. The methods use a combined gradient waveform that provides adequate sensitivity for concurrent encodings of flow and tissue stiffness. During a scan, the application of the combined gradient waveform, in the presence of an applied... Ohio State Innovation Foundation

11/23/17 / #20170333493

Probiotic bacteria for the prevention and treatment of salmonella

As disclosed herein, fructose-asparagine (F-Asn) is a primary nutrient utilized during Salmonella-mediated gastroenteritis. Engineered bacteria are disclosed that can compete with Salmonella for F-Asn and other nutrients and withstand Salmonella-induced inflammation. These bacterium can be used as probiotics to treat and prevent Salmonella-mediated gastroenteritis.... Ohio State Innovation Foundation

11/23/17 / #20170335472

Catalytic materials and methods of making and using thereof

Iron-containing mixed-phase metal oxides are described. The mixed-phase metal oxides can exhibit electrocatalytic and/or photo-electrocatalytic activity towards reducing reactions, such as the reduction of carbon dioxide.... Ohio State Innovation Foundation

11/16/17 / #20170328904

Tethered lipoplex nanoparticle biochips and methods of use

Disclosed are compositions and methods for the use of lipoplex nanoparticle chips and arrays in the detection of/diagnosis of a disease or condition.... Ohio State Innovation Foundation

11/09/17 / #20170320941

Cs1-specific chimeric antigen receptor engineered immune effector cells

Disclosed herein are chimeric antigen receptors (CAR) that can specifically recognize tumor-associated antigens (TAA) on multiple myeloma (MM) cells. Also disclosed are immune effector cells, such as T cells or Natural Killer (NK) cells, that are engineered to express these CARs. Therefore, also disclosed are methods of providing an anti-tumor... Ohio State Innovation Foundation

11/09/17 / #20170323460

Image color data normalization and color matching system for translucent material

A shade selection program is disclosed that predicts the shade choice with the smallest CIEDE2000 color difference for dental composite resin restorations when given a backing and target shade. By utilizing generated regression models, a database of spectral reflectance information, and principles of Kubelka-Munk layering, a highly accurate shade selection... Ohio State Innovation Foundation

11/02/17 / #20170313763

Compositions and methods related to viral vaccines

Provided herein are methods and compositions relating to Infectious Bursal Disease Virus (IBDV), and vaccines for treatment and prevention thereof.... Ohio State Innovation Foundation

11/02/17 / #20170314033

Herbicide-resistant taraxacum kok-saghyz and taraxacum brevicorniculatum

The invention provides the genetically manipulated herbicide-resistant rubber producing dandelion plants and seed of said plants. Another aspect of the invention comprises progeny plants, or seeds, or regenerable parts of plants and seeds of the genetically manipulated herbicide-resistant dandelion plants. Applicants have further found that use of root cells for... Ohio State Innovation Foundation

11/02/17 / #20170315203

Perforator phase contrast angiography (ppca)

The present disclosure is directed to methods and systems for fusing Phase Contrast Angiography (PCA) with anatomic images to create a perforator PCA (pPCA) data set. In the pPCA) method, vascular and anatomic information may be provided by different MRI sequences. A four-point acquisition scheme may be used for 3D... Ohio State Innovation Foundation

10/26/17 / #20170304261

Silvestrol, silvestrol analogs and uses thereof

Disclosed herein are treatment methods, vaccination methods, compositions, co-therapeutic methods, combination therapeutic compositions and kits comprising silvestrol and silvestrol analogs alone or in combination with therapeutic and preventative therapies. Disclosed herein are also methods, compositions and kits that can be used to treat cancer, viral infections, to modulate the immune... Ohio State Innovation Foundation

10/26/17 / #20170304383

Small molecule ras inhibitors

Disclosed herein are novel compounds that are Ras inhibitors. Also disclosed are compositions comprising the compounds and methods of using the compounds in treating various diseases. In another aspect, provided is an antibody-drug-conjugate comprising an antibody conjugated with a compound described herein. In still another aspect, provided is a pharmaceutical... Ohio State Innovation Foundation

10/26/17 / #20170304571

Intubation with audiovibratory guidance

Systems and methods are provided for inserting an endoscope through an anatomical cavity to a target site. A speaker is positioned externally proximate to a patient and the endoscope is inserted into the anatomical cavity. A signal is received from at least one sensor positioned near the distal end of... Ohio State Innovation Foundation

10/26/17 / #20170305959

Antileishmanial compositions and methods of use

In one aspect, the invention relates methods and compositions for treating parasitic diseases, for example, leishmaniasis. In a further aspect, the compounds of the methods and compositions are isolated from Pentalinon andrieuxii. This abstract is intended as a scanning tool for purposes of searching in the particular art and is... Ohio State Innovation Foundation

10/26/17 / #20170306337

Bioproduct formation from a plasmid addiction system in the absence of co-inducers and antibiotics

Described herein are plasmid addiction systems comprising a host cell comprising one or more inactivated host cell essential genes; and a plasmid comprising one or more plasmid essential genes operably linked to a constitutively active promoter. Also described herein are metabolism-based plasmid addiction systems (PAS) comprising a host cell and... Ohio State Innovation Foundation

10/26/17 / #20170307748

Systems and methods for measuring wave fields of a body of water

This disclosure relates to systems and methods for measuring wave fields of a body of water. A system can include a radiation source and an antenna that can cooperate with the radiation source to transmit a radio frequency (RF) signal to a wave field having one or more waves. The... Ohio State Innovation Foundation

10/26/17 / #20170307955

Devices and methods for implementing an optical switching engine

Disclosed herein are various improvements in optical switching engines. In one aspect, a range of switching engines includes various multiple bounce, multiple image devices, such as, for example, the Herriott Cell and the Robert Cell. In another aspect, liquid crystal spatial light modulators (SLMs) are used in the switching engine... Ohio State Innovation Foundation

10/26/17 / #20170308782

Stretchable broad impedance bandwidth rfid devices

According to the embodiments described herein, a stretchable RFID device can include an RFID chip and an RFID antenna. The RFID antenna can be electrically coupled and mechanically attached to the RFID chip. The RFID antenna can be impedance matched to the RFID chip across a broad bandwidth and can... Ohio State Innovation Foundation

10/19/17 / #20170298395

Autotrophic hydrogen bacteria and uses thereof

In an aspect, the invention relates to compositions and methods production of n-butanol by aerobic hydrogen bacteria. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.... Ohio State Innovation Foundation

10/19/17 / #20170298446

Biomarkers of bruton tyrosine kinase inhibitor resistance

Biomarkers and methods are disclosed that identify patients being treated with a BTK inhibitor that have acquired a mutation that will cause resistance to the BTK inhibitor. Therefore, also disclosed is a method for treating a hematological cancer in the patient that involves detecting an acquired mutation that causes resistance... Ohio State Innovation Foundation

10/12/17 / #20170291253

Hybrid structures for joining of metals and continuous fiber materials

A transition structure includes a metallic portion, a fiber portion including a plurality of tows embedded within the metallic portion and extending out from the metallic portion forming a fabric, and a binding material forming a matrix surrounding the fiber portion embedded within the metallic portion. The fiber portion may... Ohio State Innovation Foundation

10/05/17 / #20170281723

Improved peptidyl calcineurin inhibitors

Improved calcineurin inhibitors and methods of using these improved calcineurin inhibitors to inhibit calcineurin-NFAT signaling in cells and in subjects are disclosed.... Ohio State Innovation Foundation

10/05/17 / #20170281740

Serodiagnosis of salmon poisoning disease

Neorickettsia helminthoeca is an obligate intra-cytoplasmic bacterium that causes salmon poisoning disease (SPD), an acute, febrile, fatal disease of dogs. Disclosed are compositions and methods for the immunodetection of N. helminthoeca in a canine subject. Also disclosed are immunogenic N. helminthoeca peptides that can be used in a vaccine for... Ohio State Innovation Foundation

09/28/17 / #20170273608

Ionic barrier for floating gate in vivo biosensors

An ion-sensitive sensor includes a dielectric layer comprising Al2O3 having a functionalized surface configured to bond with an analyte. The ion-sensitive sensor is immersed in an electrolytic solution containing a concentration of alkali ions. An electrode is arranged to apply an electric potential to the functionalized surface of the ion-sensitive... Ohio State Innovation Foundation

09/28/17 / #20170279739

Predictive network system and method

A proactive networking system and method is disclosed. The network anticipates the user demands in advance and utilizes this predictive ability to reduce the peak to average ratio of the wireless traffic and yield significant savings in the required resources to guarantee certain Quality of Service (QoS) metrics. The system... Ohio State Innovation Foundation

09/21/17 / #20170268591

Designs and manufacturing methods for lightweight hyperdamping materials providing large attenuation of broadband-frequency structure-borne sound

A hyperdamping inclusion under constraint with large, broadband frequency damping properties is disclosed. The inclusion includes materials under near-buckling constraint such that fundamental eigenfrequency vanishes at near-buckling.... Ohio State Innovation Foundation

09/21/17 / #20170269188

Folded transducer array for compact and deployable wave-energy guiding system

A wave energy guiding system is described that includes a structural substrate formed according to a folded-pattern topology including, for example, an origami-type folded-pattern topology such as Miura-ori. The structural substrate includes a plurality of planar facets each positionable at an angle relative to adjacent planar facets. Each transducer of... Ohio State Innovation Foundation

09/21/17 / #20170272158

Driver system with an optical power based isolated power supply

The present invention relates to a driver system that can include an optical power based isolated power supply. The driver system can include an optical receiver that can be in communication with an optical transmitter to receive an optical signal. The optical receiver can be configured to convert the optical... Ohio State Innovation Foundation

08/24/17 / #20170241817

Velocity vector field mapping using electrical capacitance sensors

The present invention provides a system and method for velocity vector field calculation at the voxel level of a multi-phase flow system using Electrical Capacitance Volume Tomography sensors.... Ohio State Innovation Foundation

Patent Packs
08/17/17 / #20170232501

Hot forming of cooling galleries in steel pistons

A piston, particularly a piston for use in a diesel engine, particularly a heavy duty diesel engine, is formed from a billet of metal, such that the finished piston has a mass that is at least 50%, and, more preferably, up to about 62%, of the mass of the billet.... Ohio State Innovation Foundation

08/10/17 / #20170224259

Magnetic resonance imaging method to non-invasively measure blood oxygen saturation

Methods for data acquisition and processing of magnetic resonance (MR) imaging to obtain the oxygen saturation (O2sat) of blood using a relationship between transverse relaxation time (T2) of blood and oxygen saturation. The method includes obtaining multiple images at various T2 preparation times. Next, non-linear curve fitting may be used... Ohio State Innovation Foundation

08/10/17 / #20170224833

Self-assembling molecules that accumulate in acidic tumor microenvironments

Disclosed are compositions that contain a plurality of biocompatible self-assembling molecules that transform from isolated molecules or spherical micelles while in blood serum into cylindrical nanofibers in the acidic extracellular environment of tumors, which can be used to achieve a higher relative concentration of imaging drug delivery, or radiotherapeutic agents... Ohio State Innovation Foundation

08/03/17 / #20170216458

Intrathecal delivery of recombinant adeno-associated virus 9

The present invention relates to Adeno-associated virus type 9 methods and materials useful for intrathecal delivery of polynucleotides. Use of the methods and materials is indicated, for example, for treatment of lower motor neuron diseases such as SMA and ALS as well as Pompe disease and lysosomal storage disorders. It... Ohio State Innovation Foundation

08/03/17 / #20170218081

Methods and compositions related to antibody fragments that bind to tumor-associated glycoprotein 72 (tag-72)

Disclosed herein are methods and compositions related to antibody fragments which specifically bind sialyl-Tn epitope of tumor-associated glycoprotein 72 (TAG-72).... Ohio State Innovation Foundation

07/27/17 / #20170209504

Probiotic formulations and methods for use

Provided herein are compositions comprising a biocompatible microsphere, a biofilm-generating probiotic bacterium, a prebiotic, and/or a prebiofilmic. Methods for preparing and formulating the compositions and methods for treating or preventing a disease using the compositions are also provided.... Ohio State Innovation Foundation

07/27/17 / #20170209584

Compositions for targeting macrophages and other cd206 high expressing cells and methods of treating and diagnosis

Provided are compounds and compositions for targeting macrophages and other CD206 high expressing cells.... Ohio State Innovation Foundation

07/27/17 / #20170209838

Composite membranes for separation of gases

Membranes, methods of making the membranes, and methods of using the membranes are described herein. The membranes can comprise a gas permeable support layer, an inorganic layer disposed on the support, the inorganic layer comprising a plurality of discreet nanoparticles having an average particle size of less than 1 micron,... Ohio State Innovation Foundation

07/20/17 / #20170202969

Compounds and compositions for targeting macrophages and other mannose-binding c-type lectin receptor high expressing cells and methods of treating and diagnosis using same

Provided are compounds and compositions for targeting macrophages and other mannose-binding c-type lectin receptor high expressing cells and methods of treatment and diagnosis using such compounds and compositions.... Ohio State Innovation Foundation

07/13/17 / #20170200906

Germanane analogs and optoelectronic devices using the same

The present invention provides novel two-dimensional van der Waals materials and stacks of those materials. Also provided are methods of making and using such materials.... Ohio State Innovation Foundation

07/06/17 / #20170196074

Liquid thin-film laser target

Described in this disclosure is a laser target comprised of a liquid film creation device that is configured to form a liquid laser target. Methods of forming a liquid thin-film laser target are also described.... Ohio State Innovation Foundation

06/29/17 / #20170184614

Methylated peptides derived from tau protein and their antibodies for diagnosis and therapy of alzheimer's disease

In sporadic Alzheimer's disease, neurofibrillary lesion formation is preceded by extensive post-translational modification of the microtubule associated protein tau. Immunoassays have been developed recently that detect tau in biological specimens, thus providing a means for pre-mortem diagnosis of Alzheimer's disease, which has remained elusive. These assays have been improved by... Ohio State Innovation Foundation

06/08/17 / #20170157397

Devices, systems, and methods for treating obstetric and gynecological disorders

One aspect of the present disclosure relates to a therapy delivery device for treating an obstetric or gynecological disorder other than urinary incontinence in a subject. The therapy delivery device can include a housing, at least one electrode, and a power source. The housing can be configured for implantation in... Ohio State Innovation Foundation

05/11/17 / #20170130752

Welding methods and welded joints for joining high-strength aluminum alloys

Welding methods and welded joints for improving corrosion resistance of the joint between a plurality of high-strength aluminum alloy structural members are described herein. An example method can include applying a first weld at a junction between the plurality of high-strength aluminum alloy structural members using a first filler metal,... Ohio State Innovation Foundation

05/11/17 / #20170131267

Devices and methods for the rapid and accurate detection of analytes

Disclosed are field effect transistor-based (FET-based) sensors for the rapid and accurate detection of analytes both in vivo and in vitro. The FET-based sensors can include a substrate, a channel disposed on the substrate, a source electrode and a drain electrode electrically connected to the channel, and a recognition element... Ohio State Innovation Foundation

Patent Packs
05/04/17 / #20170119806

Arylnaphthalene lactone derivatives and methods of making and using thereof

A series of natural products including phyllanthusum, an arylnaphthalene lignan derivative, with anticancer and antitumor and immunostimulating activity are disclosed. The invention further encompasses methods of adding water solubilizing groups to the arylrings that include phosphonyl groups.... Ohio State Innovation Foundation

05/04/17 / #20170120046

Systems and methods of improving an inflammatory disorder

Methods for improving an inflammatory disorder in a subject are provided. Methods include positioning a therapy delivery device on a neural target site that contributes to immune activity of the subject. The therapy delivery device is activated to deliver a therapy signal to the neural target site to improve the... Ohio State Innovation Foundation

05/04/17 / #20170120055

Systems and methods for treating autonomic instability and medical conditions associated therewith

One aspect of the present disclosure relates to a closed-loop therapy system for treating autonomic instability or a medical condition associated therewith in a subject. The therapy delivery system can include a sensing component, a delivery component, and a controller. The sensing component can be configured to detect at least... Ohio State Innovation Foundation

04/27/17 / #20170112896

Small molecule rac or rho inhibitors

Disclosed herein are methods of inhibiting Rac or Rho in a cell or tissue or for treating a disease mediated at least in part by Rac or Rho, using a compound of the formula:... Ohio State Innovation Foundation

04/27/17 / #20170115244

Thermal simulator

A thermal simulator simulates the thermal behavior of items such as eggs for which the actual internal temperature profile is difficult to measure. A yolk body simulates the egg yolk, an albumen body surrounds the yolk body and simulates the egg albumen, and a shell layer surrounds the albumen body... Ohio State Innovation Foundation

04/13/17 / #20170100588

Systems and methods of improving cancer symptoms by neuromodulation of immune function

Methods for improving cancer symptoms in a subject are provided. Methods include positioning a therapy delivery device on a neural target site that contributes to immune activity of the subject. The therapy delivery device is activated to deliver a therapy signal to the neural target site to improve the subject's... Ohio State Innovation Foundation

04/13/17 / #20170100589

Systems and methods of improving infections by neuromodulation of immune function

Methods for improving infection in a subject are provided. Methods include positioning a therapy delivery device on a neural target site that contributes to immune activity of the subject. The therapy delivery device is activated to deliver a therapy signal to the neural target site to improve the subject's infection.... Ohio State Innovation Foundation

04/13/17 / #20170100604

Systems and methods of improving metabolic syndrome

Methods for improving metabolic syndrome in a subject are provided. Methods include positioning a therapy delivery device on a neural target site that contributes to immune activity of the subject. The therapy delivery device is activated to deliver a therapy signal to the neural target site to improve the subject's... Ohio State Innovation Foundation

04/13/17 / #20170100605

Systems and methods of improving an immune disorder

Methods for improving an immune disorder in a subject are provided. The immune disorder can be an autoimmune disorder, a hypersensitivity syndrome, or an immune deficiency syndrome. Methods include positioning a therapy delivery device on a neural target site that contributes to immune activity of the subject. The therapy delivery... Ohio State Innovation Foundation

04/13/17 / #20170101681

Mirna biomarkers for monitoring bone marrow reconstitution

Disclosed herein are compositions and methods for monitoring hematopoietic reconstitution or suppression in a subject. Also disclosed are compositions and methods for reconstituting the hematopoietic compartment of a subject in need thereof. Also disclosed is a method for monitoring the effect of ionizing radiation on the lung in a subject.... Ohio State Innovation Foundation

04/13/17 / #20170103528

Volumetric texture score

During LTS calculations, first gray level transformations are applied to DICOM images, followed by two-point correlation function based threshold calculations being applied to each pixel (voxel) in the given volume. Finally these calculations lead into estimation of textures within the given volume (LTS). This algorithm, which is initially implemented in... Ohio State Innovation Foundation

03/30/17 / #20170087530

Methods for producing nanoparticles and using same

A method for producing nanocomposite particles is provided. The method comprises supplying an organic phase fluid an organic phase fluid, an aqueous phase fluid, an amphiphile, and a plurality of hydrophobic nanospecies to a nozzle. An electric field is generated proximate the nozzle such that the fluid exiting the nozzle... Ohio State Innovation Foundation

03/23/17 / #20170080078

Compositions and methods for treating and preventing porcine reproductive and respiratory syndrome

Disclosed herein are methods and compositions for treating or preventing Porcine reproductive and respiratory syndrome (PRRS) infection in a subject.... Ohio State Innovation Foundation

03/23/17 / #20170080081

Paramyxovirus immunogens and related materials and methods

Described herein are methyltransferase (MTase)-defective recombinant viruses as vaccines for human metapneumovirus (hMPV), human respiratory syncytial virus (hRSV), and human parainfluenza virus type 3 (PIV3); as well as related materials and methods.... Ohio State Innovation Foundation

03/23/17 / #20170082868

Contact lens comprising lenticular-like curve

Disclosed herein is a contact lens comprising a rounded, minus-carrier, lenticular-like curve over a central, upper portion of the lens that allows the contact lens to translate upwards in downgaze.... Ohio State Innovation Foundation

03/16/17 / #20170072041

Ehrlichial invasin for immuniztion, diagnosis, and cell delivery

Disclosed are vaccines containing one or more immunogenic polypeptides derived from an EtpE protein from an Ehrlichia sp. or nucleic acid encoding these polypeptides. Also disclosed is a method for vaccinating a subject against Ehrlichia sp. that involves administering to the subject a composition comprising any of the disclosed vaccines.... Ohio State Innovation Foundation

03/02/17 / #20170055823

Method of identifying an eye disorder of an observer and implementing the same

In one embodiment, the invention provides the use of an interocular inhibition procedure (IIP) for discriminating between anisometropic amblyopia and myopia, two disorders commonly confused in visual examination without proper optical correction. The inventors identified that opaque and translucent patching over the fellow (or untested) eye would result in different... Ohio State Innovation Foundation

03/02/17 / #20170056346

Methods and compositions for treating multiple myeloma

Methods and compositions for sensitizing multiple myeloma cells to treatment with IMiDs are provided. Aspects include methods of administering AR-42 and an IMiD (e.g., lenalidomide, pomalidomide) to multiple myeloma patients.... Ohio State Innovation Foundation

03/02/17 / #20170056834

Multilayer coatings and methods of making and using thereof

Multilayer coatings, articles comprising multilayer coatings, and methods of making and using thereof are described herein. The multilayer coating can contain two or more oppositely charged alternating layers, comprising at least one fixed layer comprising a first polymer and at least one inorganic layer comprising a plurality of particles, wherein... Ohio State Innovation Foundation

03/02/17 / #20170056839

Membranes for gas separation

Membranes, methods of making the membranes, and methods of using the membranes are described. The membranes can comprise a support layer, and a selective polymer layer disposed on the support layer. The selective polymer layer can comprise an oxidatively stable carrier dispersed within a hydrophilic polymer matrix. The oxidatively stable... Ohio State Innovation Foundation

02/23/17 / #20170051005

Primers and methods for nucleic acid amplification

A primer and method for amplification of a target nucleic acid, the primer adapted to conform into a conformation that dissociates from a complementary strand of DNA duplex. The conformation may have a free energy with more favorable thermodynamics than a corresponding DNA duplex, such as a B-DNA duplex. The... Ohio State Innovation Foundation








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