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Oregon Health x26 Science University
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Oregon Health & Science University patents


Recent patent applications related to Oregon Health & Science University. Oregon Health & Science University is listed as an Agent/Assignee. Note: Oregon Health & Science University may have other listings under different names/spellings. We're not affiliated with Oregon Health & Science University, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "O" | Oregon Health & Science University-related inventors


 new patent  Compounds, compositions and associated methods comprising 3-aryl quinolines

Compounds, compositions and methods useful for treating infectious diseases are provided. In particular, 3-aryl quinoline compounds, their synthesis, pharmaceutical compositions thereof and methods of treating infectious diseases such as malaria, are disclosed.... Oregon Health & Science University

Synergistic co-administration of computationally optimized broadly reactive antigens for h1n1 influenza

The present invention provides co-administration (for example, immunogenic cocktail compositions and/or prime-boost regimens) of computationally optimized H1N1 influenza hemagglutinin (HA) polypeptides. Co-administration of the optimized H1N1 influenza hemagglutinin (HA) polypeptides facilitates synergistic neutralization of viral infection and provides for improved protective immunity (e.g., a broad reactive immune response) to diverse... Oregon Health & Science University

Recombinant cd74 polypeptides

Disclosed are recombinant CD74 polypeptides mutated relative to the naturally occurring CD74 polypeptides with improved properties such as binding of CD74 ligands such as MIF and RTL1000 as well as polynucleotides that encode the polypeptides, expression vectors comprising the polynucleotides, bacteria that include the expression vectors, and methods of making... Oregon Health & Science University

Pharmaceutical compositions comprising microrna

Pharmaceutical compositions comprising one or more of miR-494-3p, miR-99b-5p, and/or miR-21-3p and a pharmaceutically acceptable carrier as well as methods of using said compositions to treat cancer characterized by aberrant activity of an MRN complex.... Oregon Health & Science University

Cmv glycoproteins and recombinant vectors

This invention also relates to recombinant vectors expressing one or more of the human CMV (HCMV) glycoproteins US2, US3, US6 and US11 or corresponding functional rhesus CMV (RhCMV) homologues Rh182, Rh184, Rh185 or Rh189, methods of making them, uses for them, expression products from them, and uses for the expression... Oregon Health & Science University

Instruments used in collecting fluid samples

Disclosed are instruments used in collecting fluid samples from a subject such as, for example, aqueous humor samples. The instrument involves a linear actuator that, when engaged by the user via a switch, causes a syringe held within the instrument to collect a defined amount of sample. Kits comprising the... Oregon Health & Science University

Systems and methods to compensate for reflectance variation in oct angiography

Methods and systems for improving quantification of OCT angiography data are disclosed. The disclosure specifically relates to methods for compensating for the effect of tissue reflectance to improve the accuracy and repeatability of OCT angiography measurements. These improvements are effected by deriving and then utilizing a dynamic thresholding approach to... Oregon Health & Science University

Compounds that bind dystroglycan and uses thereof

Disclosed herein are methods and compositions involved in identifying cells that lack apico-basal polarity as well as methods and compositions involved in selectively delivering payload molecules to cells that lack apico-basal polarity, and methods of selecting test compounds that restore apico-basal polarity.... Oregon Health & Science University

Vmat inhibitory compounds

Disclosed herein are compounds that bind to the vesicular monoamine transporter 2 (VMAT2), pharmaceutical compositions comprising those compounds, and methods of treatment using said compounds and pharmaceutical compositions.... Oregon Health & Science University

Telecentive spirometer

Systems and methods to encourage a patient to use an incentive spirometer (IS) device according to the schedule prescribed by a clinician are described. The systems and methods for a clinician-programmable IS device that can automatically monitor patient usage, and, in the event of non-compliance, effect an automatic shutdown of... Oregon Health & Science University

5'-triphosphate oligoribonucleotides

Disclosed herein are synthetic oligoribonucleotides that form hairpin loop structures. The oligoribonucleotides can be used in the treatment of viral infection including prophylactic treatments. The oligoribonucleotides can also be used as adjuvants.... Oregon Health & Science University

Methods, systems, and apparatuses for quantitative analysis of heterogeneous biomarker distribution

Methods, systems, and apparatuses for detecting and describing heterogeneity in a cell sample are disclosed herein. A plurality of fields of view (FOV) are generated for one or more areas of interest (AOI) within an image of the cell sample are generated. Hyperspectral or multispectral data from each FOV is... Oregon Health & Science University

Aptamer-rnai therapeutic compositions

A recombinant nucleic acid comprising an aptamer that binds CD4 and an RNAi sequence that silences the expression of RORγ2 is described herein. Pharmaceutical compositions comprising the recombinant nucleic acid, particularly topical compositions are also described. Methods of treating inflammatory disease using the pharmaceutical composition are also described.... Oregon Health & Science University

Derivatives of bodipy

Derivatives of BODIPY with improved properties (such as longer Stokes shift relative to existing fluorophores) are disclosed.... Oregon Health & Science University

Rtef-1 variants and uses thereof

Disclosed are variant RTEF-1 polypeptides having an RTEF-1 amino acid sequence with one or more internal deletions, wherein the polypeptides reduce VEGF promoter activity. Some of the RTEF-1 polypeptides include an amino acid sequence that is at least 80% identical to the contiguous amino acids of 1) amino acids 24... Oregon Health & Science University

Pd-1 modulation and uses thereof for modulating hiv replication

Methods, uses, compositions and kits for modulating HIV replication based on PD-1 modulation are disclosed. Methods, uses, compositions and kits useful for the elimination of latent HIV reservoirs based on PD-1 inhibition are also disclosed. Methods and kits useful for identifying agents useful for modulating HIV replication are also disclosed.... Oregon Health & Science University

Deep brain electrode placement and stimulation based on brown adipose tissue temperature

Systems and methods for deep brain electrode placement and deep brain stimulation (DBS) for treatment of conditions such as obesity are disclosed. In one example approach, during placement of a deep brain stimulating electrode in a target region of the brain of a patient, a temperature of brown adipose tissue... Oregon Health & Science University

Anti-factor xi monoclonal antibodies and methods of use thereof

Compositions and methods for inhibiting thrombosis without compromising hemostasis are described. Compositions include anti-factor XI monoclonal antibodies (aXIMabs) capable of binding to an epitope on the heavy chain of human FXI, particularly the A3 domain of the heavy chain of human FXI. Compositions also include epitope-binding fragments, variants, and derivatives... Oregon Health & Science University

Recombinant t cell receptor ligand compositions and methods for treatment of prostate cancer

Disclosed herein are compositions and methods for treating or inhibiting prostate cancer. The compositions include a MHC molecule including covalently linked first and second domains, wherein the first domain is an MHC class II β1 domain and the second domain is an MHC class II α1 domain, wherein the amino... Oregon Health & Science University

Animation-based autism spectrum disorder assessment

Systems and methods for quantitative assessment of autism spectrum disorder based on detected responses of a subject to displayed animations are disclosed. In one example approach, a method for performing an autism assessment of a subject includes presenting as animation on a display, tracking the subject's eye gaze location on... Oregon Health & Science University

Administration of a thiol-based chemoprotectant compound

A method of administration of a thiol-based chemoprotectant agent including NAC (N-acetylcysteine) and STS (sodium thiosulfate) that markedly affects biodistribution and protects against injury from diagnostic or therapeutic intra-arterial procedures. A method for treating or mitigating the side effects of cytotoxic cancer therapy for tumors located in the head or... Oregon Health & Science University

Optical coherence tomography glaucoma detection based on retinal vessel relief height

Systems and techniques for detecting glaucoma in a subject based on retinal vessel relief height obtained from optical coherence tomography (OCT) image data are disclosed. In one example approach, a retinal vessel relief height relative to a retinal plane may be calculated from OCT image data and the presence or... Oregon Health & Science University

Systems and methods to remove shadowgraphic flow projections in oct angiography

Methods and systems for suppressing shadowgraphic flow projection artifacts in OCT angiography images of a sample are disclosed. In one example approach, normalized OCT angiography data is analyzed at the level of individual A-scans to classify signals as either flow or projection artifact. This classification information is then used to... Oregon Health & Science University

Human pluripotent stem cells produced by somatic cell nuclear transfer

Human pluripotent embryonic stem cells produced by somatic cell nuclear transfer as well as methods of making and using said human pluripotent embryonic stem cells are disclosed.... Oregon Health & Science University

Cmv vectors comprising microrna recognition elements

Disclosed herein are recombinant CMV vectors comprising heterologous antigens and microRNA recognition elements to silence expression of CMV genes in the presence of microRNA derived from myeloid cells, an active UL128 protein and an active UL130 protein. Also disclosed are recombinant CMV vectors comprising heterologous antigens and microRNA recognition elements... Oregon Health & Science University

Dengue virus vaccine

Recombinant fusion proteins including a dengue virus EIII and an E2 subunit derived from a thermophilic bacterium are described. Also described are expression vectors including a polynucleotide that encodes the recombinant fusion protein and a promoter. Also described are vaccine compositions that include either the recombinant fusion protein, polynucleotide, or... Oregon Health & Science University

Acridone compounds

A class of acridone compounds has been discovered that exhibits chemosensitizing and antiparasitic activity. Described herein are pharmaceutical compositions and methods for their use to treat parasitic infections, such as malaria and toxoplasmosis, and to sensitize resistant cells, such as multidrug resistant cells to other therapeutic agents. The pharmaceutical compositions... Oregon Health & Science University

Methods of detecting cancers sensitive to cabozantinib

The emergence of resistance to targeted therapy is a recurrent clinical challenge and requires development and validation of secondary agents with improved activity. Accompanied by experimental cell-based and structural validation, this report of a near complete response to cabozantinib in a ROS1-rearranged lung adenocarcinoma patient with acquired resistance to crizotinib... Oregon Health & Science University

Sting agonists and methods of selecting sting agonists

Disclosed are small molecules capable of activating the type I interferon (IFN) response by way of the transcription factor IFN regulatory factor 3 (IRF3) were identified. A high throughput in vitro screen yielded 4-(2-chloro-6-fluorobenzyl)-N-(furan-2-ylmethyl)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazine-6-carboxamide (referred to herein as G10), which was found to trigger IRF3/IFN-associated transcription in human fibroblasts. To... Oregon Health & Science University

Systems and methods for retinal layer segmentation in oct imaging and oct angiography

Disclosed herein are methods and systems for segmenting, visualizing, and quantifying the layered structure of retina in optical coherence tomography datasets. The disclosed methods have particular application to OCT angiography data, where specific retina layers have distinct vascular structures and characteristics that can be altered in various pathological conditions of... Oregon Health & Science University

Compounds that bind macrophage migration inhibitory factor

Recombinant polypeptides, pharmaceutical compositions comprising recombinant polypeptides, and methods of treating autoimmune and/or inflammatory diseases using the pharmaceutical compositions are disclosed. The polypeptides are based upon the trimerization and/or MIF binding domains of CD74.... Oregon Health & Science University

Normalization of the enterohepatic circulation in animals with a chimeric humanized liver

Methods of normalizing bile acid production in a mouse engrafted with human hepatocytes by the administration of human FGF19 are disclosed. Also disclosed is a transgenic host animal, such as a mouse, that expresses human FGF19 that has normalized bile acid production when engrafted with human hepatocytes.... Oregon Health & Science University

Methods involving macrophage tumor cell fusion hybrids

Methods of identifying circulating macrophage-tumor cell fusion hybrids from a subject, methods of screening test compounds for inhibition of activity of in vitro and in vivo derived macrophage-tumor cell fusion hybrids, and methods of assessing the probability of survival of a human subject with pancreatic cancer past one year are... Oregon Health & Science University

High efficiency scalable structure

A building may include a floor, a dome having a vent, and an internal ceiling that divides areas underneath the dome into first and second chambers. The internal ceiling may have an aperture that is structured to allow air to pass from the first chamber into the second chamber. The... Oregon Health & Science University

Systems and methods for functional imaging of the placenta

A method for imaging and quantifying placental blood perfusion using magnetic resonance imaging is disclosed. The method provides a noninvasive means of assessing placental function and oxygenation from T2* images without the administration of an exogenous contrast agent. The method provides quantitative information regarding the number and spatial distribution of... Oregon Health & Science University

03/30/17 / #20170087062

Dental composites

Disclosed herein are methacrylate compounds that can be used as components of dental composites. Also disclosed are dental composites comprising the compositions and thiourethane oligomers.... Oregon Health & Science University

03/09/17 / #20170067908

Methods of viral neutralizing antibody epitope mapping

Disclosed herein are methods of high-throughput mapping of viral neutralizing antibody epitopes. Also disclosed are in vitro immunoprecipitation-based adenoassociated virus Barcode-Seq-based methods of mapping viral neutralizing antibody epitopes. In some embodiments, a method of high-throughput mapping of viral NtAb conformational epitopes can be utilized, which may comprise HP scanning of... Oregon Health & Science University

03/02/17 / #20170055829

Systems and methods of gluacoma diagnosis based on frequency analysis of inner retinal surface profile measured by optical coherence tomography

A method for detecting glaucoma in a subject based on spatial frequency analysis of the inner limiting membrane (ILM) as obtained from optical coherence tomography (OCT) image data is disclosed. Based on the spatial frequency content of the analyzed ILM profile, a quantity called the Retinal surface contour variability (RSCV)... Oregon Health & Science University

02/23/17 / #20170053378

Methods of enhancing digital images

Disclosed are methods of enhancing the resolution of 2-dimensional digital images and 3-dimensional volume reconstructions by using the random translational shifts and rotations present in a series of raw images to generate a single higher resolution image or volume. The methods allow the generation of a super-resolution image or volume... Oregon Health & Science University

02/16/17 / #20170044625

Methods of diagnosing and treating acml and cnl

Disclosed herein are methods and kits used in treating a cancer characterized by aberrant activity of CSF3R. These methods involve detecting a mutation in exon 14 of CSF3R such as a mutation of T615 or T618 and treating the subject with a JAK inhibitor and/or detecting a mutation in exon... Oregon Health & Science University

02/09/17 / #20170035830

Compositions and methods for treating heart disease and/or injury

A method of treating heart disease and/or injury in a subject includes administering to the subject a therapeutic agent that inhibits one or more of catalytic activity, signaling, and function of PTPσ.... Oregon Health & Science University

02/09/17 / #20170038365

Small molecule inhibitors of 8-oxoguanine dna glycosylase-1 (ogg1)

Disclosed herein are methods of identifying small molecule compounds that are likely to be OGG1 inhibitors, kits that facilitate the performance of the methods, and methods of inhibiting OGG1 in vitro and in vivo.... Oregon Health & Science University

02/02/17 / #20170027977

Methods useful in the prevention of hypoxic injury

Methods useful in the treatment of cytotoxic insults such as excitotoxic injury, ischemic injury, and hypoxic injury are disclosed. The methods involve the treatment of the cytotoxic insult with a pharmaceutical composition comprising poly-ICLC.... Oregon Health & Science University

02/02/17 / #20170028048

Methods for producing an immune response to tuberculosis

Methods for producing an immune response to Mycobacterium tuberculosis (Mtb) are disclosed herein. In several examples, the immune response is a protective immune response. In additional embodiments, methods are disclosed for inhibiting an infection with Mtb, preventing an infection with Mtb, or treating an infection with Mtb. Pharmaceutical compositions for... Oregon Health & Science University

01/26/17 / #20170022164

Quinolone-3-diarylethers

Disclosed are derivative compounds of ELQ-300 that include an ester at position 4. These compounds have enhanced properties relative to ELQ-300. Also disclosed are pharmaceutical compositions comprising the compounds and methods of treating and preventing malaria infections involving administering the pharmaceutical compositions to the subject.... Oregon Health & Science University

01/26/17 / #20170023550

Engineered three-dimensional breast tissue, adipose tissue, and tumor disease model

Described are three-dimensional, engineered, biological breast tissues, adipose tissues, and tumor models, including breast cancer models.... Oregon Health & Science University

01/12/17 / #20170007681

Methods and compositions used in treating inflammatory and autoimmune diseases

Methods of treating neuroinflammation by administration of a selective protein C activator, such as recombinant human WE thrombin and optionally one or more of its cofactors are disclosed. Also disclosed are pharmaceutical compositions for use in the treatment of mammals that exhibit symptoms of neurological inflammation. The pharmaceutical compositions and... Oregon Health & Science University

01/12/17 / #20170009293

Methods and kits used in identifying microrna targets

Described herein are methods and kits used to identify an endogenously expressed target mRNA of a microRNA of interest. The method involves the use of a dominant negative GW182 polypeptide that forms a stable complex with the target mRNA. The method further involves purifying the complex and identifying the target... Oregon Health & Science University








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