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Piramal Enterprises Limited patents


Recent patent applications related to Piramal Enterprises Limited. Piramal Enterprises Limited is listed as an Agent/Assignee. Note: Piramal Enterprises Limited may have other listings under different names/spellings. We're not affiliated with Piramal Enterprises Limited, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "P" | Piramal Enterprises Limited-related inventors


A process for the preparation of verapamil hydrochloride

A process for the preparation of 5-(3,4-dimethoxyphenylethyl) methyl-amino-2-(3,4-dimethoxyphenyl)-2-isopropyl valeronitrile, which is known as verapamil is described. A process for improving the purity of verapamil and therefore of its hydrochloride represented as the compound of formula i, by efficient removal of the impurities formed, affording a product of purity greater than 99% is described.. ... Piramal Enterprises Limited

An improved process for the preparation of clobazam and its intermediate

The present invention provides an improved process for the preparation of 8-chloro-1-phenyl-1h-benzo[b][1,4]diazepine-2,4(3h,5h)-dione (hereafter referred to as the compound (iv)), which is useful as a key intermediate for the synthesis of clobazam (referred to as the compound (i)) 7-chloro-1-methyl-5-phenyl-1h-benzo[b][1,4]diazepine-2,4(3h,5h)-dione. The process of the present invention further involves transformation of the compound (iv) into clobazam (i), comprising (a) reacting the compound (ii) (as described herein) with monoalkyl malonate in the presence of a coupling agent to obtain the compound (iii) (as described herein); followed by the cyclization using a base; (b) reacting the compound-iv (as described herein) obtained from step (a) with methylating agent. ... Piramal Enterprises Limited

Compounds containing carbon-carbon linker as gpr120 agonists

The present invention relates to compound of formula (i) containing carbon-carbon linker, a stereoisomer, a tautomer, a pharmaceutically acceptable salt, a pharmaceutically acceptable solvate, a prodrug, a polymorph, n-oxide, s-oxide, or a carboxylic acid isostere thereof; processes for their preparation; pharmaceutical compositions comprising said compounds; and their use for the treatment of the diseases or disorders mediated by gpr120 receptor.. . ... Piramal Enterprises Limited

Improved process for the preparation of lurasidone and its intermediate

The present invention provides an improved process for preparation of the substantially pure (3ar,7ar)-4′-(benzo[d]isothiazol-3-yl)octahydrospiro[isoindole-2,1′-piperazin]-1′-ium methanesulfonate (referred to as compound-ii), which is useful as a key intermediate for the synthesis of lurasidone ((3ar,4s,7r,7as)-2-{(1r,2r)-2-[4-(1,2-benzisothiazol-3-yl)piperazin-1ylmethyl]cyclohexylmethyl}hexahydro-4,7-methano-2h-isoindole-1,3-dione). The process comprises reaction of the compound-iii (as described herein) with the compound-iv (as described herein) in the presence of a solvent mixture selected from an alcohol and water; and a base the improved process for the preparation of compound ii provides the product with total amount of unreacted compound-iv as impurity in less than 0.06% and the product with hplc purity as ≧99.8%. ... Piramal Enterprises Limited

Fused heterocyclic compounds as gpr120 agonists

The present invention relates to fused heterocyclic compound of formula (i), a stereoisomer, a tautomer, a pharmaceutically acceptable salt, a pharmaceutically acceptable solvate, a prodrug, a polymorph, n-oxide, s-oxide, or a carboxylic acid isostere thereof; processes for their preparation; pharmaceutical compositions comprising said compounds; and their use for the treatment of the diseases or disorders mediated by gpr120 receptor.. . ... Piramal Enterprises Limited

Stable injectable composition of pharmaceutically active agents and process for its preparation

The present invention relates to a stable, non-aqueous and ready-to-use injectable composition of a pharmaceutically active agent a pharmaceutically active agent or a pharmaceutically acceptable salt or a co-crystal thereof. The present invention also relates to a process for the preparation of the stable, non-aqueous and ready-to-use injectable composition of pharmaceutically active agent involving use of a non-solvent solvent system suitable for preparing a stabilized injectable composition comprising a pharmaceutically active agent a pharmaceutically active agent or a pharmaceutically acceptable salt or a co-crystal thereof. ... Piramal Enterprises Limited

Stable injectable composition of bivalirudin and process for its preparation

The present invention relates to a non-aqueous, stable and ready-to-use injectable composition of bivalirudin or pharmaceutically acceptable salt(s) or co-crystals thereof; and processes for its preparation. It is not required to reconstitute the injectable composition of bivalirudin with water prior to administration, thereby rendering it an easy-to-use injectable composition.. ... Piramal Enterprises Limited

Substituted phenyl alkanoic acid compounds as gpr120 agonists and uses thereof

The present invention relates to substituted phenyl alkanoic acid compounds designated as the compound of formula (i) (as described herein) or a tautomer, a stereoisomer, a geometrical isomer, a pharmaceutically acceptable salt, a pharmaceutically acceptable solvate, a prodrug, a polymorph, an n-oxide, a s-oxide or a carboxylic acid isostere thereof; which are gpr120 agonists. The present invention also relates to a pharmaceutical composition of compound of formula (i) for the treatment of diseases or disorder mediated by gpr120.. ... Piramal Enterprises Limited

Compounds for the treatment of cancers associated with human papillomavirus

The present invention relates to the pyrrolidine substituted with flavone derivatives, represented by the compounds of formula (i) or a pharmaceutically acceptable salt, a solvate, a stereoisomer or a diastereoisomer thereof for use in the treatment of cancers associated with human papillomavirus. The present invention also relates to the pharmaceutical compositions containing the compounds of formula (i) for the treatment of cancers associated with human papillomavirus.. ... Piramal Enterprises Limited

Piramal Enterprises Limited

. . ... Piramal Enterprises Limited

Fused triterpene compounds and uses thereof

The present invention discloses fused triterpene compounds, represented by the compounds of formula i (as described herein), processes for their preparation, pharmaceutical compositions comprising the said compounds, their use as retinoid-related orphan receptors gamma (rorγ) modulators and/or interleukin-17 (il-17) inhibitors and methods for their use in the treatment of a disease or a disorder mediated by rorγ and/or il-17.. . ... Piramal Enterprises Limited

Pharmaceutical combination for the treatment of cancer

The present invention relates to a pharmaceutical combination comprising a cdk inhibitor and at least one antioxidant enzyme inhibitor for use in the treatment of cancer. The present invention also relates to a method for the treatment of cancer comprising administering to a subject in need thereof, a therapeutically effective amount of a cdk inhibitor and a therapeutically effective amount of at least one antioxidant enzyme inhibitor. ... Piramal Enterprises Limited

Pyrrolidine- substituted flavone derivatives for prevention or treatment of oral mucositis

The present invention relates to the pyrrolidine substituted with flavone derivatives, represented by the compounds of formula (i) (as described herein) or pharmaceutically acceptable salts, solvates, stereoisomers or diastereoisomers thereof or pharmaceutical compositions containing the compounds of formula (i) for use in the prevention and/or treatment of oral mucositis caused by cancer therapy such as radiation therapy.. . ... Piramal Enterprises Limited








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