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President And Fellows Of Harvard College
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President And Fellows Of Harvard College patents


Recent patent applications related to President And Fellows Of Harvard College. President And Fellows Of Harvard College is listed as an Agent/Assignee. Note: President And Fellows Of Harvard College may have other listings under different names/spellings. We're not affiliated with President And Fellows Of Harvard College, we're just tracking patents.

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Artificial tympanic membrane devices and uses

This disclosure features artificial tympanic membrane graft devices and two-component bilayer graft devices that include a scaffold having a plurality of ribs made of a first material and a plurality of spaces between the ribs filled or made with the first material, a different, second material, a combination of the... President And Fellows Of Harvard College

Single-stranded dna nanostructures

The present disclosure relates to nanostructures assembled from nucleic acid consisting of a single strand of DNA rationally-designed to self-assemble into a hairpin loop, helical domains, and locking domains.... President And Fellows Of Harvard College

Method and system for polarization state generation

An apparatus for polarization state generation and phase control includes a Stokes Basis generator to generate multiple Stokes Bases from one or more input beams, an intensity modulator to modulate an intensity of each of the Stokes Bases, and a beam combiner to combine the modulated Stokes Bases into an... President And Fellows Of Harvard College

High ph organic flow battery

Provided herein are redox flow (e.g., rechargeable) batteries having a first aqueous electrolyte including a first type of redox active material (e.g., a quinone or alloxazine) and a second aqueous electrolyte including a second type of redox active material. The invention also features a method for storing electrical energy involving... President And Fellows Of Harvard College

Scaffolds for cell collection or elimination

A device that includes a scaffold composition and a bioactive composition with the bioactive composition being incorporated therein or thereon, or diffusing from the scaffold composition such that the scaffold composition and/or a bioactive composition captures and eliminates undesirable cells from the body a mammalian subject. The devices mediate active... President And Fellows Of Harvard College

Methods of generating functional human tissue

Methods of tissue engineering, and more particularly methods and compositions for generating various vascularized 3D tissues, such as 3D vascularized embryoid bodies and organoids are described. Certain embodiments relate to a method of generating functional human tissue, the method comprising embedding an embryoid body or organoid in a tissue construct... President And Fellows Of Harvard College

Droplet-based composite single-cell nucleic acid analysis

The present invention generally relates to a combination of molecular barcoding and emulsion-based microfluidics to isolate, lyse, barcode, and prepare nucleic acids from individual cells in a high-throughput manner.... President And Fellows Of Harvard College

Single cell nucleic acid detection and analysis

Methods and compositions for digital profiling of nucleic acid sequences present in a sample are provided.... President And Fellows Of Harvard College

Soft actuators and soft actuating devices

A soft buckling linear actuator is described, including: a plurality of substantially parallel bucklable, elastic structural components each having its longest dimension along a first axis; and a plurality of secondary structural components each disposed between and bridging two adjacent bucklable, elastic structural components; wherein every two adjacent bucklable, elastic... President And Fellows Of Harvard College

Systems, methods, and workflows for optogenetics analysis

The invention provides methods for characterizing cellular physiology by incorporating into an electrically excitable cell an optical reporter of, and an optical actuator of, electrical activity. A signal is obtained from the optical reporter in response to a stimulation of the cell. Either or both of the optical reporter and... President And Fellows Of Harvard College

Optogenetic probes for measuring membrane potential

The invention provides methods, cells and constructs for optical measurement of membrane potential. These methods can be used in cells that are not accessible to presently available methods using electrodes. The methods can be directed to, for example, high-throughput drug screening assays to determine agents that can affect membrane potential... President And Fellows Of Harvard College

Peritumoral and intratumoral materials for cancer therapy

The invention provides methods and compositions for reducing tumor-mediated immune evasion and inducing patient-specific immunization.... President And Fellows Of Harvard College

System and a biomimetic fluid processing

A system and method are provided for harvesting target biological substances. The system includes a substrate and a first and second channel formed in the substrate. The channels longitudinally extending substantially parallel to each other. A series of gaps extend from the first channel to the second channel to create... President And Fellows Of Harvard College

Assay and other reactions involving droplets

The present invention generally relates to droplets and/or emulsions, such as multiple emulsions. In some cases, the droplets and/or emulsions may be used in assays, and in certain embodiments, the droplet or emulsion may be hardened to form a gel. In some aspects, a heterogeneous assay can be performed using... President And Fellows Of Harvard College

Systems and methods for epigenetic sequencing

The present invention generally relates to microfluidics and/or epigenetic sequencing. In one set of embodiments, cells contained within a plurality of microfluidic droplets are lysed and the DNA (e.g., from nucleosomes) within the droplets are labeled, e.g., with adapters containing an identification sequence. The adapters may also contain other sequences,... President And Fellows Of Harvard College

Fluid-based gating mechanism with tunable multiphase selectivity and antifouling behavior

A gating mechanism that uses a capillary stabilized liquid as a reversible, reconfigurable gate that fills and seals pores in the closed state, and creates a non-fouling, liquid-lined pore in the open state is disclosed. Theoretical modeling and experiments demonstrate that for each transport substance, the gating threshold—the pressure needed... President And Fellows Of Harvard College

Fluidic device for quantifying the dynamic permeability and hydraulic conductivitiy of living tissue layers

Systems and methods for measuring dynamic hydraulic conductivity and permeability associated with a cell layer are disclosed. Some systems include a microfluidic device, one or more working-fluid reservoirs, and one or more fluid-resistance element. The microfluidic device includes a first microchannel, a second microchannel, and a barrier therebetween. The barrier... President And Fellows Of Harvard College

Systems, methods, and kits for amplifying or cloning within droplets

The present invention generally relates to droplet-based microfluidic devices, including systems, methods, and kits for amplifying or cloning within droplets. In some embodiments, the present invention is generally directed to systems, methods, or kits for amplifying a plurality of nucleic acids, e.g., without substantially selectively amplifying some nucleic acids over... President And Fellows Of Harvard College

Device and hybrid feedback control of a switch-capacitor multi-unit voltage regulator

A device and method for hybrid feedback control of a switch-capacitor multi-unit voltage regulator are presented. A multi-unit switched-capacitor (SC) core includes a plurality of SC converter units, each unit with a capacitor and a plurality of switches controllable by a plurality of switching signals. Power switch drivers provide a... President And Fellows Of Harvard College

Systems and methods for an automated barbecue smoker

Devices, systems, and computer-readable medium are provided for a barbecue smoker device. A barbecue smoker device is provided, that includes a multi-wall container, a food platform, a heat source, an air vent at the top of the barbecue smoker device, an air flow control mechanism at the lower portion of... President And Fellows Of Harvard College

Soft exosuit for assistance with human motion

Systems and methods for providing assistance with human motion, including hip and ankle motion, are disclosed. Sensor feedback is used to determine an appropriate profile for actuating a wearable robotic system to deliver desired joint motion assistance. Variations in user kinetics and kinematics, as well as construction, materials, and fit... President And Fellows Of Harvard College

Fluidic device for quantifying the dynamic permeability and hydraulic conductivitiy of living tissue layers

Systems and methods for measuring dynamic hydraulic conductivity and permeability associated with a cell layer are disclosed. Some systems include a microfluidic device, one or more working-fluid reservoirs, and one or more fluid-resistance element. The microfluidic device includes a first microchannel, a second microchannel, and a barrier therebetween. The barrier... President And Fellows Of Harvard College

Zero-porosity npr structure and tuning of npr structure for particular localities

The present concepts include a zero-porosity structure having a plurality of structural elements arranged to provide a negative Poisson's ratio and, further, a new mechanism to generate negative Poisson's ratio is single material, zero-porosity structure.... President And Fellows Of Harvard College

Proline-locked stapled peptides and uses thereof

The present invention provides a new type of alpha-helix nucleating cross-link (“staple”) formed by olefin metathesis of a proline derivative with an alkenyl side chain and another amino acid derivative with an alkenyl side chain. The proline derivatives as described herein have been found to be strong nucleators of alpha-helix... President And Fellows Of Harvard College

Plasmonic nanocavity-based cell therapy method and system

In one aspect, a structure for use in transfecting cells is disclosed, which comprises a matrix supporting a plurality of cavities, each cavity having an opening characterized by a rim and an inner surface subtending and/or extending from said rim. An electrically conductive coating is disposed on a top surface... President And Fellows Of Harvard College

Microscope-free imaging

Provided herein, in some aspects, are methods of imaging molecules without a microscope or other specialized equipment, referred to herein as “microscope-free imaging (MFI).” Herein, “molecular instruments” (e.g., DNA-based and protein-based molecules) are used, instead of microscopes, in a “bottom-up” approach for inspecting molecular targets.... President And Fellows Of Harvard College

Purification of germ stem cells by targeting mrp9

Provided herein are methods and compositions for the purification and detection of germ stem cells (e.g., oogonial stem cells) based on expression of MRP9.... President And Fellows Of Harvard College

Frizzled 2 as a target for therapeutic antibodies in the treatment of cancer

Disclosed herein are methods of treating cancer in a subject, and methods for inhibiting growth, migration and/or invasion of a cancer cell in the subject, comprising administering to the subject a therapeutically effective amount of an antibody or antigen binding fragment thereof that downmodulales Fzd2. The antibody may specifically bind... President And Fellows Of Harvard College

Pneumatic insect robots

A modular pneumatic robotic actuator, including a first elongated hollow structure and a second elongated hollow structure connected to each other at a moveable joint; an inflatable bladder comprised of an elastomeric material disposed at the said joint and immobilized between the first and second hollow structures, wherein the said... President And Fellows Of Harvard College

Gene editing through microfluidic delivery

Gene editing can be performed by introducing gene-editing components into a cell by mechanical cell disruption. Related apparatus, systems, techniques, and articles are also described. The methods and systems of the invention solve the problem of intracellular delivery of gene editing components and gene editing complexes to target cells. The... President And Fellows Of Harvard College

Compositions of microbiota and methods related thereto

Methods and compositions are provided for treating weight related conditions and metabolic disorders by altering microbiota in a subject. One aspect provides methods and compositions to alter microbiota in a subject by administering to the subject a composition that includes a substantially purified microbiota from phyla such as Bacteroidetes, Proteobacteria,... President And Fellows Of Harvard College

Methods and 3d printing of point cloud data

An unorganized point cloud may be created by an optical 3D scanner that scans a physical object, or by computer simulation. The point cloud may be converted into binary raster layers, which encode material deposition instructions for a multi-material 3D printer. In many cases, this conversion—from point cloud to binary... President And Fellows Of Harvard College

Nucleic acid-based linkers for detecting and measuring interactions

The invention provides compositions comprising nucleic acid complexes for use in monitoring binding interactions and in measuring association and/or dissociation kinetics, detecting analytes including low concentration analytes, and screening library members. In some instances, the nucleic acid complexes are double-stranded nicked nucleic acids comprising a scaffold nucleic acid hybridized to... President And Fellows Of Harvard College

Auxetic structures with distorted projection slots in engineered patterns to provide npr behavior and improved stress performance

Auxetic structures, effusion-cooling auxetic sheets, systems and devices with auxetic structures, and methods of using and methods of making auxetic structures are disclosed. An auxetic structure is disclosed which includes an elastically rigid body with opposing top and bottom surfaces. First and second pluralities of elongated apertures extend through the... President And Fellows Of Harvard College

Brain in vitro models, devices, systems, and methods of use thereof

Exemplary embodiments provide in vitro brain models, such as in vitro models of a neurovascular unit or a functionally connected trineural pathway, and systems, devices and methods of use thereof. The present invention provides in vitro brain models, systems, devices and methods that mimic in vivo conditions to, for example,... President And Fellows Of Harvard College

12/21/17 / #20170360279

Modular, millimeter-scale, light-intensity-based force sensing system

A light-intensity-based forced sensor comprises a Sarrus linkage, a biasing mechanism, a light emitter, and a light detector includes a first plate, a second plate, and at least one collapsible linkage pivotably coupled to both the first and the second plates. The biasing mechanism biases the collapsible linkage toward an... President And Fellows Of Harvard College

12/21/17 / #20170361318

Electronic control of fluidic species

Various aspects of the present invention relate to the control and manipulation of fluidic species, for example, in microfluidic systems. In one aspect, the invention relates to systems and methods for making droplets of fluid surrounded by a liquid, using, for example, electric fields, mechanical alterations, the addition of an... President And Fellows Of Harvard College

12/21/17 / #20170362307

Engineered microbe-targeting molecules and uses thereof

Described herein are engineered microbe-targeting or microbe-binding molecules, kits comprising the same and uses thereof. Some particular embodiments of the microbe-targeting or microbe-binding molecules comprise a carbohydrate recognition domain of mannose-binding lectin, or a fragment thereof, linked to a portion of a Fc region. In some embodiments, the microbe-targeting molecules... President And Fellows Of Harvard College

12/21/17 / #20170363648

Biosensors engineered from conditionally stable ligand-binding domains

Disclosed is a biosensor engineered to conditionally respond to the presence of specific small molecules, the biosensors including conditionally stable ligand-binding domains (LBDs) which respond to the presence of specific small molecules, wherein readout of binding is provided by reporter genes or transcription factors (TFs) fused to the LBDs.... President And Fellows Of Harvard College

12/21/17 / #20170363880

Direct laser writing of 3-d gratings and diffraction optics

Diffractive optical elements and methods for their fabrication are disclosed. In one aspect, a diffractive optical element is disclosed, which comprises a polymeric substrate substantially transparent to at least one electromagnetic radiation wavelength, and a plurality of metallic inclusions distributed in said polymeric substrate according to a predefined pattern such... President And Fellows Of Harvard College

12/21/17 / #20170365476

Creation of hyperdoped semiconductors with concurrent high crystallinity and high sub-bandgap absorptance using nanosecond laser annealing

In one aspect, a method of processing a semiconductor substrate is disclosed, which comprises incorporating at least one dopant in a semiconductor substrate so as to generate a doped polyphase surface layer on a light-trapping surface, and optically annealing the surface layer via exposure to a plurality of laser pulses... President And Fellows Of Harvard College

12/14/17 / #20170354937

Fluid injection

The present invention generally relates to systems and methods for the control of fluids and, in some cases, to systems and methods for flowing a fluid into and/or out of other fluids. As examples, fluid may be injected into a droplet contained within a fluidic channel, or a fluid may... President And Fellows Of Harvard College

12/14/17 / #20170355962

Methods of reprogramming cells

The present invention provides methods of reprogramming cells, for example, directly reprogramming a somatic cell of a first cell type into a somatic cell of a second cell type, are described herein. In particular, the present invention generally relates to methods for reprogramming a cell of an endoderm origin to... President And Fellows Of Harvard College

12/14/17 / #20170356899

Detecting gases and respiration by the conductivity of water within a porous substrate sensor

A method of and system for detecting a gas or vapor includes providing a sensor comprising an electrode pair in electrical contact with a layer of porous material, the porous material layer having water adsorbed on its surface; contacting the sensor with a gas or vapor sample to be analysed;... President And Fellows Of Harvard College

12/07/17 / #20170349950

T cell balance gene expression, compositions of matters and methods of use thereof

This invention relates generally to compositions and methods for identifying the regulatory network that modulates, controls or otherwise influences T cell balance, for example, Th17 cell differentiation, maintenance and/or function, as well compositions and methods for exploiting the regulatory network that modulates, controls or otherwise influences T cell balance in... President And Fellows Of Harvard College

12/07/17 / #20170350885

Assays for antimicrobial activity and applications thereof

The disclosure provides methods, compositions, and kits for enhanced detection of microbes in samples and monitoring of antimicrobial activity in a subject.... President And Fellows Of Harvard College

12/07/17 / #20170352542

Nanoscale wires with tip-localized junctions

The present invention generally relates to nanoscale wires and, in particular, to nanoscale wires with heterojunctions, such as tip-localized homo- or heterojunctions. In one aspect, the nanoscale wire may include a core, an inner shell surrounding the core, and an outer shell surrounding the inner shell. The outer shell may... President And Fellows Of Harvard College

11/30/17 / #20170340588

Modulation of regulatory t cells via g-coupled protein receptor 43

Disclosed herein are compositions and methods that are useful for inducing the development of regulatory T cells (Treg). Such compositions and methods are useful for treating inflammatory conditions and in particular inflammatory conditions affecting the gastrointestinal tract of a subject. In certain embodiments, the present inventions generally relate to short... President And Fellows Of Harvard College

11/30/17 / #20170342109

Natural igm antibodies and inhibitors thereof

The invention provides natural IgM antibody inhibitors that may be used to treat various inflammatory diseases or disorders.... President And Fellows Of Harvard College

11/23/17 / #20170333895

Matrix-assisted spectrophotometry

Disclosed herein are multiwell plates suitable for spectrophotometry for low-volume liquid samples. For the multiwell plates, the bottom of at least one well has a layer of porous matrix disposed thereon, or is comprised of a layer of porous matrix. The layer of porous matrix permits a low-volume liquid sample... President And Fellows Of Harvard College

11/23/17 / #20170333914

Magnetic capture of a target from a fluid

Disclosed herein is an improved method for magnetic capture of target molecules (e.g., microbes) in a fluid. Kits and solid substrates for carrying the method described herein are also provided. In some embodiments, the methods, kits, and solid substrates described herein are optimized for separation and/or detection of microbes and... President And Fellows Of Harvard College

11/23/17 / #20170333941

High energy efficiency phase change device using convex surface features

Sub-micrometer to centimeter scale rough symmetric and asymmetric structures are incorporated onto objects (e.g. tubes and fms). Asymmetric and hierarchically structured slippery structures can be applied to a broad range of materials and shapes of surfaces for manufacturing heat exchangers, dew harvesting devices, desalination devices, de-humidifiers, distillation towers, evaporation coils,... President And Fellows Of Harvard College

11/23/17 / #20170337323

Methods of making polypeptides with non-standard amino acids using genomically recoded organisms

A method of making a polypeptide including at least one covalent bond between a pair of reactive side chains of corresponding amino acids, wherein the covalent bond is insensitive to reduction is provided including genetically modifying a genomically recoded organism to express a corresponding synthetase, tRNA or synthetase/tRNA pair for... President And Fellows Of Harvard College

11/23/17 / #20170337324

Methods for retrievable information storage using nucleic acids

A method of storing information using monomers such as nucleotides is provided including converting a format of information into a plurality of bit sequences of a bit stream with each having a corresponding bit barcode, converting the plurality of bit sequences to a plurality of corresponding oligonucleotide sequences using one... President And Fellows Of Harvard College

11/23/17 / #20170337342

Method and using gait analysis to determine a health quality measure

A method, computer-readable storage device and apparatus for calculating a health quality measure are disclosed. For example, a method receives characteristics of motion information, wherein the characteristics of motion information is based upon gait information, monitors the characteristics of motion information over a time period to determine a plurality of... President And Fellows Of Harvard College

11/16/17 / #20170327781

Organomimetic devices and methods of use and manufacturing thereof

An organomimetic device includes a microfluidic device that can be used to culture cells in its microfluidic channels. The organomimetic device can be part of dynamic system that can apply mechanical forces to the cells by modulating the microfluidic device and the flow of fluid through the microfluidic channels. The... President And Fellows Of Harvard College

11/16/17 / #20170327888

Triggered assembly of metafluorophores

Aspects of the present disclosure relate to systems, kits and methods that comprise a nucleic acid capture strand linked to a first dye molecule, a nucleic acid trigger strand longer than the capture strand and comprising (a) a capture domain that is complementary to the capture strand and (b) at... President And Fellows Of Harvard College

11/16/17 / #20170329086

Apparatus for coupling to high-index micro-resonators with tapered optical fibers

Tapered waveguides made of high-index material attached to a tapered optical fiber are provided, enabling access to the optical modes of large, high-index resonators. In some embodiments, an optical fiber having a central axis, a tapered portion, and an untapered portion is provided. The tapered portion is configured to expose... President And Fellows Of Harvard College

11/09/17 / #20170319443

Multiple emulsions comprising rigidified portions

The present invention generally relates to microfluidic droplets and, in particular, to multiple emulsion microfluidic droplets. In one set of embodiments, multiple emulsion droplets are provided, where an inner shell of the droplet is relatively thin, compared to the outer shell (or other shells) of the droplet. For instance, in... President And Fellows Of Harvard College

11/09/17 / #20170319517

Methods, compositions, and kits for treating pain and pruritis

The invention features a method for inhibiting one or more voltage-gated ion channels in a cell by contacting the cell with (i) a first compound that activates a channel-forming receptor that is present on nociceptors and/or pruriceptors; and (ii) a second compound that inhibits one or more voltage-gated ion channels... President And Fellows Of Harvard College

11/09/17 / #20170320886

Cortistatin analogues and syntheses thereof

and salts thereof, wherein R1, R2, R3, R4, n, and m are as defined herein; processes for preparing such compounds and intermediates thereto; pharmaceutical compositions comprising such compounds; methods for treating a proliferative disease; methods for treating a disease associated with aberrant angiogenesis; methods for inhibiting angiogenesis; and processes for... President And Fellows Of Harvard College

11/09/17 / #20170320928

Alpha/beta-polypeptide analogs of glucagon-like peptide 1

Described herein are peptide analogs of glucagon-like peptide 1 (GLP-1) that retain agonist activity, but are more resistant to proteolytic degradation than native GLP-1. In the analogs, at least one α-amino acid found in the native GLP-1 is replaced with a β-amino acid residue, which may or may not be... President And Fellows Of Harvard College

11/09/17 / #20170321177

Acoustic waves in microfluidics

Various aspects of the present invention relate to the control and manipulation of fluidic species, for example, in microfluidic systems. In one set of embodiments, droplets may be sorted using surface acoustic waves. The droplets may contain cells or other species. In some cases, the surface acoustic waves may be... President And Fellows Of Harvard College

11/09/17 / #20170321198

Novel crispr enzymes and systems

The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered RNA-targeting systems comprising a novel RNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA.... President And Fellows Of Harvard College

11/09/17 / #20170321284

Clonal haematopoiesis

The present invention relates to clonal expansion of somatic cells in subjects, and acquired selective advantage of cell clones during the lifetime of a subject. In particular, the invention relates to methods for predicting the development of cancer based on the observation of specific genetic mutations in somatic cell clones,... President And Fellows Of Harvard College

Patent Packs
11/09/17 / #20170322196

Multiphase systems and uses thereof

A multi-phase system includes a phase-separated solution comprising at least two phases, each phase having a phase component selected from the group consisting of a polymer, a surfactant and combinations thereof, wherein at least one phase comprises a polymer, wherein the phases, taken together, represent a density gradient. Novel two-phase,... President And Fellows Of Harvard College

11/02/17 / #20170313757

Optogenetic probes for measuring membrane potential

Provided herein are variants of an archaerhodopsin useful for application such as optical measurement of membrane potential. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, cells comprising the polynucleotides, and cells comprising the polypeptides; and methods of using the variants.... President And Fellows Of Harvard College

11/02/17 / #20170313767

Methods of diagnosis and treatment of tuberculosis and infection

Described herein are methods of treating, diagnosing, and/or prognosing a disease in a subject relating to detection of the glycosylation state of the antibodies present in the subject. In some embodiments, the disease can be an infection. In some embodiments, an antibody glycosylation state that is indicative of the presence... President And Fellows Of Harvard College

11/02/17 / #20170314538

Flexible thin robotic actuators

Some embodiments of the disclosed subject matter includes a laminated robotic actuator. The laminated robotic actuator includes a strain-limiting layer comprising a flexible, non-extensible material in the form of a sheet or thin film, a flexible inflatable layer in the form of a thin film or sheet in facing relationship... President And Fellows Of Harvard College

10/26/17 / #20170304213

Amphiphile-polymer particles

This invention relates to amphiphile-polymer particles comprising obtaining a first solution comprising a water-insoluble polymer, a payload and a first amphiphile in a water-miscible solvent; mixing the first solution with an aqueous second solution to form an aqueous composition comprising a particle comprising a water-insoluble polymeric core comprising the water-insoluble... President And Fellows Of Harvard College

10/26/17 / #20170305824

Small molecule inhibitors of necroptosis

The invention features a series of heterocyclic derivatives that inhibit tumor necrosis factor alpha (TNF-α) induced necroptosis. The heterocyclic compounds of the invention are described by Formulas (I)-(VIII) and by Compounds (1)-(7), (13)-(26), (27)-(33), (48)-(57), and (58)-(70). These necrostatins are shown to inhibit TNF-α induced necroptosis in FADD-deficient variant of... President And Fellows Of Harvard College

10/26/17 / #20170305953

14-membered ketolides and methods of their preparation and use

Provided herein are methods of preparing new 14-membered ketolides via coupling of an eastern and western half moiety, followed by macro-cyclization, and optional functionalization. Intermediates in the synthesis of these ketolides including the eastern and western halves are also provided. Pharmaceutical compositions and methods of treating infectious diseases and inflammatory... President And Fellows Of Harvard College

10/26/17 / #20170306030

Chimeric activators: quantitatively designed protein therapeutics and uses thereof

Aspects of the invention provide methods for harnessing the potential of proteins that occur naturally (e.g., in humans) and that have serious but finite toxicity. Aspects of the invention relate to a quantitative systems-biological and structural approach to design a class of chimeric proteins that avoid the toxicity of protein... President And Fellows Of Harvard College

10/26/17 / #20170306307

Crispr having or associated with destabilization domains

The disclosure includes non-naturally occurring or engineered CRISPR Cas9, each associated with at least one destabilization domain (DD), along with compositions, systems and complexes involving the DD-CRISPR Cas9, nucleic acid molecules and vectors encoding the same, delivery systems involving the same, uses therefor.... President And Fellows Of Harvard College

10/26/17 / #20170306335

Rna-targeting system

The invention provides for systems, methods, and compositions for targeting RNA. In particular, the invention provides a non-naturally occurring or engineered RNA-targeting system comprising an RNA-targeting Cas protein and at least one RNA-targeting guide RNA, wherein said RNA-targeting guide RNA is capable of hybridizing with a target RNA in a... President And Fellows Of Harvard College

10/19/17 / #20170298128

Methods and compositions for treating age-related disorders

The present invention relates to methods and compositions containing an antagonist of a negative regulator of GDF-11 (e.g., an antibody) for use in treating an age-related condition. In particular the methods and compositions can be used to treat an age related cardiovascular condition such as diastolic heart failure.... President And Fellows Of Harvard College

10/19/17 / #20170298342

Systems and methods for amplification and phage display

The present invention generally relates to amplification of biological entities, for example, for phage display. In one aspect, members of a library of biological entities are encapsulated in separate compartments (e.g., in separate microfluidic droplets) and amplified. As a specific example, by putting members of a phage display library into... President And Fellows Of Harvard College

10/19/17 / #20170298344

De novo design of allosteric proteins

Methods and compositions for making and isolating allosteric DNA binding proteins that bind to one or more allosteric effectors to induce a conformation change in the proteins are provided.... President And Fellows Of Harvard College

10/19/17 / #20170298402

Self-labeling nucleic acids and methods of use

Some aspects of this disclosure relate to the identification of reactive nucleic acids, such as, for example, reactive cellular RNAs. Minimal reactive motif consensus sequences and isolated reactive nucleic acids conforming to such consensus sequences are provided herein. Reactive probes that selectively form covalent bonds with reactive nucleic acids are... President And Fellows Of Harvard College

10/19/17 / #20170298407

Engineered water nanostructures (ewns) and uses thereof

Various embodiments of the present invention relate to, among other things, systems for generating engineered water nanostructures (EWNS) comprising reactive oxygen species (ROS) and methods for inactivating at least one of viruses, bacteria, bacterial spores, and fungi in or on a wound of a subject in need thereof or on... President And Fellows Of Harvard College

Patent Packs
10/19/17 / #20170298441

Use of clonal evolution analysis for ibrutinib resistance in chronic lymphocytic leukemia patients

The present invention generally relates to the methods and use of clonal evolution analysis of the kinetics and genetic alterations associated with the development of resistance to a therapy using whole-exome and deep targeted sequencing in treating patients in need thereof.... President And Fellows Of Harvard College

10/19/17 / #20170299664

Use of nuclear spin impurities to suppress electronic spin fluctuations and decoherence in composite solid-state spin systems

A solid state electronic spin system contains electronic spins disposed within a solid state lattice and coupled to an electronic spin bath and a nuclear spin bath, where the electronic spin bath composed of electronic spin impurities and the nuclear spin bath composed of nuclear spin impurities. The concentration of... President And Fellows Of Harvard College

10/12/17 / #20170290681

Portable prosthetic hand with soft pneumatic fingers

A finger actuator, includes a plurality of fluidically interconnected inflatable chambers, wherein each chamber comprises outer walls having an embedded extensible layer selected to constrain radial expansion and freestanding inner walls; and an inextensible layer connected to the chambers at a base of the chambers, the inextensible layer comprising a... President And Fellows Of Harvard College

10/05/17 / #20170282133

In vitro evolution in microfluidic systems

The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising the steps of: (a) compartmentalising genetic elements into microcapsules; and (b) sorting the genetic elements which express the gene product having the desired activity; wherein at least one step... President And Fellows Of Harvard College

10/05/17 / #20170283471

Modified microbial toxin receptor for delivering agents into cells

We described a novel system of targeted cell therapy with a protein toxin, such as anthrax toxin, that has been modified to re-direct it to a desired cell target instead of its natural cell target. The system can be used for, e.g., targeted killing of undesired cells in a population... President And Fellows Of Harvard College

10/05/17 / #20170283831

Protected guide rnas (pgrnas)

The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are structural information on the Cas protein of the CRISPR-Cas system, use of this information in generating modified components of the CRISPR complex, vectors and vector systems which encode one... President And Fellows Of Harvard College

09/28/17 / #20170273930

Methods to treat neurodegenerative diseases

The specification provides compositions and methods to treat neurodegenerative diseases.... President And Fellows Of Harvard College

09/28/17 / #20170275623

Cancer treatment and immune system regulation through fat10 pathway inhibition

Described herein are methods of inhibiting mitosis, treating cancer and/or treating immune disorders through the use of agents that inhibit FAT10 and/or the FAT10 pathway.... President And Fellows Of Harvard College

09/28/17 / #20170276929

Pop-up laminate structure including miniature optical components

A pop-up laminate structure includes rigid layers, at least one flexible layer, at least one optical component, and an actuator. At least one of the rigid layers defines gaps extending there through to form a plurality of rigid segments separated by the gaps in the rigid layer. The flexible layer... President And Fellows Of Harvard College

09/21/17 / #20170265788

Systems and methods for making and using sensors, probes, and other devices

The present invention generally relates, in some aspects, to systems and methods for making and using sensors or other devices, such as optical components. One aspect is generally directed to a sensor or other device comprising a nanometer-sized portion. In some embodiments, the sensor can be used to determine various... President And Fellows Of Harvard College

09/21/17 / #20170266236

Devices for wound healing

The present invention provides devices and methods for improving wound healing, in particular, in diabetic subjects.... President And Fellows Of Harvard College

09/21/17 / #20170266320

Rna-guided systems for in vivo gene editing

Methods of editing target nucleic acids are provided using a guide RNA and a Cas9 protein to excise exons in a target gene and where the edited gene is expressed to produce a truncated polypeptide.... President And Fellows Of Harvard College

09/21/17 / #20170267630

Class-and isoform-specific hdac inhibitors and uses thereof

HDAC inhibitors of the general formula (I) and (II) and pharmaceutically acceptable salts thereof, as described herein, are useful as inhibitors of histone deacetylases or other deacetylases, and thus are useful for the treatment of various diseases and disorders associated with acetylase/deacetylase activity as described herein (e.g., cancer). In certain... President And Fellows Of Harvard College

09/21/17 / #20170268022

Cas9 proteins including ligand-dependent inteins

Some aspects of this disclosure provide compositions, methods, systems, and kits for controlling the activity of RNA-programmable endonucleases, such as Cas9, or for controlling the activity of proteins comprising a Cas9 variant fused to a functional effector domain, such as a nuclease, nickase, recombinase, deaminase, transcriptional activator, transcriptional repressor, or... President And Fellows Of Harvard College

09/21/17 / #20170268061

Methods of detecting diseases or conditions using phagocytic cells

This invention provides methods of using phagocytic cells in the diagnosis, prognosis, or monitoring of diseases or conditions. The invention also provides methods of using phagocytic cells to identify markers of diseases or conditions.... President And Fellows Of Harvard College

09/21/17 / #20170269029

Nanopore sensing by local electrical potential measurement

There is provided a method for sensing the translocation of a molecule through a nanopore. In the method, there is directed to an inlet of a nanopore a molecule that is disposed in a first ionic solution of a first ionic concentration. The molecule is caused to translocate through the... President And Fellows Of Harvard College

09/21/17 / #20170271601

Organic light-emitting diode materials

Described herein are molecules for use in organic light emitting diodes. Example molecules comprise at least one moiety A and at least one moiety D. Values and preferred values of the moieties A and D are described herein. The molecules comprise at least one atom selected from Si, Se, Ge,... President And Fellows Of Harvard College

09/14/17 / #20170258551

Deposition of rfid tags

In a method for printing an RFID tag on an object, a deposition mask is applied to the surface of an object. With the deposition mask on the surface of the object, RFID materials are deposited on at least one portion of the surface exposed by aperture(s) in the deposition... President And Fellows Of Harvard College

08/31/17 / #20170246281

Pathogen vaccines and methods of producing and using the same

The present invention provides vaccine compositions and methods of producing such compositions. Other embodiments of the invention include methods of treating a pathogen infection, methods of vaccinating a subject against a pathogen infection, and methods for treating an antibiotic-resistance bacterial infection in a subject in need thereof. In further embodiments,... President And Fellows Of Harvard College

08/31/17 / #20170246634

Fluid injection using acoustic waves

The present invention generally relates to the manipulation of fluids using acoustic waves such as surface acoustic waves. In some aspects, one fluid may be introduced into another fluid via application of suitable acoustic waves. For example, a fluid may be added or injected into another fluid by applying acoustic... President And Fellows Of Harvard College

08/31/17 / #20170247456

Antibody molecules to pd-1 and uses thereof

Antibody molecules that specifically bind to PD-1 are disclosed. The anti-PD-1 antibody molecules can be used to treat, prevent and/or diagnose cancerous or infectious conditions and disorders.... President And Fellows Of Harvard College

08/31/17 / #20170248831

Multi-mode cavities for high-efficiency nonlinear wavelength conversion formed with overlap optimization

A dual frequency optical resonator configured for optical coupling to light having a first frequency ω1. The dual frequency optical resonator includes a plurality of alternating layer pairs stacked in a post configuration, each layer pair having a first layer formed of a first material and a second layer formed... President And Fellows Of Harvard College








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