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Recombinetics Inc patents

Recent patent applications related to Recombinetics Inc. Recombinetics Inc is listed as an Agent/Assignee. Note: Recombinetics Inc may have other listings under different names/spellings. We're not affiliated with Recombinetics Inc, we're just tracking patents.

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Animal models for cardiomyopathy

Genomically modified livestock animals having a modification in one or more genes implicated in heart failure are provided. The animals provide models for various pathologies in heart failure including dilated cardiomyopathy and hypertrophic cardiomyopathy and can be used for investigation of new treatment methods including interventional devices, biologics and pharmaceuticals.... Recombinetics Inc

Efficient non-meiotic allele introgression

Methods, uses, and animals for introgression of alleles between animals, including SNPs. One embodiment involves introducing a targeted targeting endonuclease system and a HDR template into a cell with a mismatch in the binding of the targeting endonuclease and the targeted site.... Recombinetics Inc

Engineering of humanized car t-cell and platelets by genetic complementation

Human or humanized tissues and organs suitable for transplant are disclosed herein. Gene editing of a host animal provides a niche for complementation of the missing genetic information by donor stem cells. Editing of a host genome to knock out or disrupt genes responsible for the growth and/or differentiation of... Recombinetics Inc

Method of generating sterile terminal sires in livestock and animals produced thereby

Disclosed herein are animals that are modified genetically to express one or more introduced sry alleles or to have a knockout of an existing sry allele. In various embodiments, the sry allele is inserted in at least one X chromosome of an XX resulting in an animal having two X... Recombinetics Inc

Genetically modified animals having increased heat tolerance

Disclosed herein are genomically modified livestock animals and methods to provide them that express the SLICK phenotype. The animals disclosed herein express a truncated allele for the prolactin receptor (PRLR) gene. When expressed, the livestock animals produce a PRLR that is missing up to the terminal 148 amino acid (aa)... Recombinetics Inc

Method of identifying the presence of foreign alleles in a desired haplotype

Methods and kits to determine the presence of exogenous alleles within a native haplotype are provided. Introduction of foreign alleles into livestock genomes has provided the ability to introduce specific desirable traits. The present disclosure provides methods to identify the presence of exogenous alleles that foreign to a haplotype at... Recombinetics Inc

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